Compound ID,Uniprot,Target,E3 ligase,PDB,Name,Smiles,DC50 (nM),Dmax (%),Assay (DC50/Dmax),"Percent degradation (%)","Assay (Percent degradation)","IC50 (nM, Protac to Target)","Assay (Protac to Target, IC50)","EC50 (nM, Protac to Target)","Assay (Protac to Target, EC50)","Kd (nM, Protac to Target)","Assay (Protac to Target, Kd)","Ki (nM, Protac to Target)","Assay (Protac to Target, Ki)","delta G (kcal/mol, Protac to Target)","delta H (kcal/mol, Protac to Target)","-T*delta S (kcal/mol, Protac to Target)","Assay (Protac to Target, G/H/-TS)","kon (1/Ms, Protac to Target)","koff (1/s, Protac to Target)","t1/2 (s, Protac to Target)","Assay (Protac to Target, kon/koff/t1/2)","IC50 (nM, Protac to E3)","Assay (Protac to E3, IC50)","EC50 (nM, Protac to E3)","Assay (Protac to E3, EC50)","Kd (nM, Protac to E3)","Assay (Protac to E3, Kd)","Ki (nM, Protac to E3)","Assay (Protac to E3, Ki)","delta G (kcal/mol, Protac to E3)","delta H (kcal/mol, Protac to E3)","-T*delta S (kcal/mol, Protac to E3)","Assay (Protac to E3, G/H/-TS)","kon (1/Ms, Protac to E3)","koff (1/s, Protac to E3)","t1/2 (s, Protac to E3)","Assay (Protac to E3, kon/koff/t1/2)","IC50 (nM, Ternary complex)","Assay (Ternary complex, IC50)","EC50 (nM, Ternary complex)","Assay (Ternary complex, EC50)","Kd (nM, Ternary complex)","Assay (Ternary complex, Kd)","Ki (nM, Ternary complex)","Assay (Ternary complex, Ki)","delta G (kcal/mol, Ternary complex)","delta H (kcal/mol, Ternary complex)","-T*delta S (kcal/mol, Ternary complex)","Assay (Ternary complex, G/H/-TS)","kon (1/Ms, Ternary complex)","koff (1/s, Ternary complex)","t1/2 (s, Ternary complex)","Assay (Ternary complex, kon/koff/t1/2)","IC50 (nM, Cellular activities)","Assay (Cellular activities, IC50)","EC50 (nM, Cellular activities)","Assay (Cellular activities, EC50)","GI50 (nM, Cellular activities)","Assay (Cellular activities, GI50)","ED50 (nM, Cellular activities)","Assay (Cellular activities, ED50)","GR50 (nM, Cellular activities)","Assay (Cellular activities, GR50)","PAMPA Papp (nm/s, Permeability)","Assay (Permeability, PAMPA Papp)","Caco-2 A2B Papp (nm/s, Permeability)","Assay (Permeability, Caco-2 A2B Papp)","Caco-2 B2A Papp (nm/s, Permeability)","Assay (Permeability, Caco-2 B2A Papp)",Article DOI,Molecular Weight,Exact Mass,XLogP3,Heavy Atom Count,Ring Count,Hydrogen Bond Acceptor Count,Hydrogen Bond Donor Count,Rotatable Bond Count,Topological Polar Surface Area,Molecular Formula,InChI,InChI Key
"1","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","953.176","952.451696628","3.03","68","7","15","3","19","189.92","C50H64N8O9S","InChI=1S/C50H64N8O9S/c1-32-45(68-31-53-32)34-10-8-33(9-11-34)25-52-47(61)41-24-36(59)27-58(41)49(63)46(50(2,3)4)54-44(60)30-67-21-20-66-19-18-56-14-16-57(17-15-56)29-40-42(64-6)22-35(23-43(40)65-7)39-28-55(5)48(62)38-26-51-13-12-37(38)39/h8-13,22-23,26,28,31,36,41,46,59H,14-21,24-25,27,29-30H2,1-7H3,(H,52,61)(H,54,60)/t36-,41+,46-/m1/s1","RPMQBLMPGMFXLD-PDUNVWSESA-N"
"1","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","15","ITC","","","-10.7","-12.5","1.8","ITC","","","","","","","","","33/24","ITC/FP","","","-10.2","-15.2","4.9","ITC","","","","","","","","","73/98","ITC/FP","","","-9.7","-6.4","-3.3","ITC between VHL and BRD9-BD:PROTAC","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","953.176","952.451696628","3.03","68","7","15","3","19","189.92","C50H64N8O9S","InChI=1S/C50H64N8O9S/c1-32-45(68-31-53-32)34-10-8-33(9-11-34)25-52-47(61)41-24-36(59)27-58(41)49(63)46(50(2,3)4)54-44(60)30-67-21-20-66-19-18-56-14-16-57(17-15-56)29-40-42(64-6)22-35(23-43(40)65-7)39-28-55(5)48(62)38-26-51-13-12-37(38)39/h8-13,22-23,26,28,31,36,41,46,59H,14-21,24-25,27,29-30H2,1-7H3,(H,52,61)(H,54,60)/t36-,41+,46-/m1/s1","RPMQBLMPGMFXLD-PDUNVWSESA-N"
"2","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1041.282","1040.50412612","2.74","74","7","17","3","25","208.38","C54H72N8O11S","InChI=1S/C54H72N8O11S/c1-36-49(74-35-57-36)38-10-8-37(9-11-38)29-56-51(65)45-28-40(63)31-62(45)53(67)50(54(2,3)4)58-48(64)34-73-25-24-72-23-22-71-21-20-70-19-18-60-14-16-61(17-15-60)33-44-46(68-6)26-39(27-47(44)69-7)43-32-59(5)52(66)42-30-55-13-12-41(42)43/h8-13,26-27,30,32,35,40,45,50,63H,14-25,28-29,31,33-34H2,1-7H3,(H,56,65)(H,58,64)/t40-,45+,50-/m1/s1","NGWWVKZONFCNQP-SHPBXJAASA-N"
"2","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1041.282","1040.50412612","2.74","74","7","17","3","25","208.38","C54H72N8O11S","InChI=1S/C54H72N8O11S/c1-36-49(74-35-57-36)38-10-8-37(9-11-38)29-56-51(65)45-28-40(63)31-62(45)53(67)50(54(2,3)4)58-48(64)34-73-25-24-72-23-22-71-21-20-70-19-18-60-14-16-61(17-15-60)33-44-46(68-6)26-39(27-47(44)69-7)43-32-59(5)52(66)42-30-55-13-12-41(42)43/h8-13,26-27,30,32,35,40,45,50,63H,14-25,28-29,31,33-34H2,1-7H3,(H,56,65)(H,58,64)/t40-,45+,50-/m1/s1","NGWWVKZONFCNQP-SHPBXJAASA-N"
"3","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35/305","Inhibit proliferation of EOL-1/A-402 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","838.919","838.3649898","0.7","61","7","15","3","18","202.97","C43H50N8O10","InChI=1S/C43H50N8O10/c1-48-24-31(28-9-10-44-23-30(28)41(48)55)27-21-35(58-2)32(36(22-27)59-3)25-50-15-13-49(14-16-50)17-18-60-19-20-61-26-38(53)46-12-11-45-33-6-4-5-29-39(33)43(57)51(42(29)56)34-7-8-37(52)47-40(34)54/h4-6,9-10,21-24,34,45H,7-8,11-20,25-26H2,1-3H3,(H,46,53)(H,47,52,54)","RMBNUDOJPQLHMV-UHFFFAOYSA-N"
"4","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","927.025","926.417419296","0.4","67","7","17","3","24","221.43","C47H58N8O12","InChI=1S/C47H58N8O12/c1-52-28-35(32-9-10-48-27-34(32)45(52)59)31-25-39(62-2)36(40(26-31)63-3)29-54-15-13-53(14-16-54)17-18-64-19-20-65-21-22-66-23-24-67-30-42(57)50-12-11-49-37-6-4-5-33-43(37)47(61)55(46(33)60)38-7-8-41(56)51-44(38)58/h4-6,9-10,25-28,38,49H,7-8,11-24,29-30H2,1-3H3,(H,50,57)(H,51,56,58)","SDNYQFJDRMQSRQ-UHFFFAOYSA-N"
"5","Q9NPI1","BRD7","DCAF15","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCC(=O)NCC2=CC=C(S(=O)(=O)NC3=CC=CC4=C3[NH]C=C4Cl)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","858.418","857.297360176","3.04","60","7","12","3","18","169.35","C43H48ClN7O8S","InChI=1S/C43H48ClN7O8S/c1-49-26-35(32-11-12-45-24-34(32)43(49)53)30-21-39(56-2)36(40(22-30)57-3)27-51-15-13-50(14-16-51)17-18-58-19-20-59-28-41(52)46-23-29-7-9-31(10-8-29)60(54,55)48-38-6-4-5-33-37(44)25-47-42(33)38/h4-12,21-22,24-26,47-48H,13-20,23,27-28H2,1-3H3,(H,46,52)","DDAXUTFTFNAHRT-UHFFFAOYSA-N"
"5","Q9H8M2","BRD9","DCAF15","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCC(=O)NCC2=CC=C(S(=O)(=O)NC3=CC=CC4=C3[NH]C=C4Cl)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","858.418","857.297360176","3.04","60","7","12","3","18","169.35","C43H48ClN7O8S","InChI=1S/C43H48ClN7O8S/c1-49-26-35(32-11-12-45-24-34(32)43(49)53)30-21-39(56-2)36(40(22-30)57-3)27-51-15-13-50(14-16-51)17-18-58-19-20-59-28-41(52)46-23-29-7-9-31(10-8-29)60(54,55)48-38-6-4-5-33-37(44)25-47-42(33)38/h4-12,21-22,24-26,47-48H,13-20,23,27-28H2,1-3H3,(H,46,52)","DDAXUTFTFNAHRT-UHFFFAOYSA-N"
"6","Q9NPI1","BRD7","DCAF15","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCC(=O)NCC2=CC=C(S(=O)(=O)NC3=CC=CC4=C3[NH]C=C4Cl)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","946.524","945.349789672","2.74","66","7","14","3","24","187.81","C47H56ClN7O10S","InChI=1S/C47H56ClN7O10S/c1-53-30-39(36-11-12-49-28-38(36)47(53)57)34-25-43(60-2)40(44(26-34)61-3)31-55-15-13-54(14-16-55)17-18-62-19-20-63-21-22-64-23-24-65-32-45(56)50-27-33-7-9-35(10-8-33)66(58,59)52-42-6-4-5-37-41(48)29-51-46(37)42/h4-12,25-26,28-30,51-52H,13-24,27,31-32H2,1-3H3,(H,50,56)","BOYHSGRAUJTFQK-UHFFFAOYSA-N"
"6","Q9H8M2","BRD9","DCAF15","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCC(=O)NCC2=CC=C(S(=O)(=O)NC3=CC=CC4=C3[NH]C=C4Cl)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","946.524","945.349789672","2.74","66","7","14","3","24","187.81","C47H56ClN7O10S","InChI=1S/C47H56ClN7O10S/c1-53-30-39(36-11-12-49-28-38(36)47(53)57)34-25-43(60-2)40(44(26-34)61-3)31-55-15-13-54(14-16-55)17-18-62-19-20-63-21-22-64-23-24-65-32-45(56)50-27-33-7-9-35(10-8-33)66(58,59)52-42-6-4-5-37-41(48)29-51-46(37)42/h4-12,25-26,28-30,51-52H,13-24,27,31-32H2,1-3H3,(H,50,56)","BOYHSGRAUJTFQK-UHFFFAOYSA-N"
"7","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1085.335","1084.53034087","2.59","77","7","18","3","28","217.61","C56H76N8O12S","InChI=1S/C56H76N8O12S/c1-38-51(77-37-59-38)40-10-8-39(9-11-40)31-58-53(67)47-30-42(65)33-64(47)55(69)52(56(2,3)4)60-50(66)36-76-27-26-75-25-24-74-23-22-73-21-20-72-19-18-62-14-16-63(17-15-62)35-46-48(70-6)28-41(29-49(46)71-7)45-34-61(5)54(68)44-32-57-13-12-43(44)45/h8-13,28-29,32,34,37,42,47,52,65H,14-27,30-31,33,35-36H2,1-7H3,(H,58,67)(H,60,66)/t42-,47+,52-/m1/s1","DRJWXYPSYGMNIH-WOPAXDDLSA-N"
"7","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1085.335","1084.53034087","2.59","77","7","18","3","28","217.61","C56H76N8O12S","InChI=1S/C56H76N8O12S/c1-38-51(77-37-59-38)40-10-8-39(9-11-40)31-58-53(67)47-30-42(65)33-64(47)55(69)52(56(2,3)4)60-50(66)36-76-27-26-75-25-24-74-23-22-73-21-20-72-19-18-62-14-16-63(17-15-62)35-46-48(70-6)28-41(29-49(46)71-7)45-34-61(5)54(68)44-32-57-13-12-43(44)45/h8-13,28-29,32,34,37,42,47,52,65H,14-27,30-31,33,35-36H2,1-7H3,(H,58,67)(H,60,66)/t42-,47+,52-/m1/s1","DRJWXYPSYGMNIH-WOPAXDDLSA-N"
"8","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOCCOCC(=O)N[C@@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.257","994.49864682","4.1","71","7","15","3","22","189.92","C53H70N8O9S","InChI=1S/C53H70N8O9S/c1-35-48(71-34-56-35)37-13-11-36(12-14-37)28-55-50(64)44-27-39(62)30-61(44)52(66)49(53(2,3)4)57-47(63)33-70-24-23-69-22-10-8-9-17-59-18-20-60(21-19-59)32-43-45(67-6)25-38(26-46(43)68-7)42-31-58(5)51(65)41-29-54-16-15-40(41)42/h11-16,25-26,29,31,34,39,44,49,62H,8-10,17-24,27-28,30,32-33H2,1-7H3,(H,55,64)(H,57,63)/t39-,44+,49-/m0/s1","BBWHDLPJYIBSPV-KKOOHVALSA-N"
"8","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOCCOCC(=O)N[C@@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.257","994.49864682","4.1","71","7","15","3","22","189.92","C53H70N8O9S","InChI=1S/C53H70N8O9S/c1-35-48(71-34-56-35)37-13-11-36(12-14-37)28-55-50(64)44-27-39(62)30-61(44)52(66)49(53(2,3)4)57-47(63)33-70-24-23-69-22-10-8-9-17-59-18-20-60(21-19-59)32-43-45(67-6)25-38(26-46(43)68-7)42-31-58(5)51(65)41-29-54-16-15-40(41)42/h11-16,25-26,29,31,34,39,44,49,62H,8-10,17-24,27-28,30,32-33H2,1-7H3,(H,55,64)(H,57,63)/t39-,44+,49-/m0/s1","BBWHDLPJYIBSPV-KKOOHVALSA-N"
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"21","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=C(OC)C=C1CN1CCN(CCOCCOCCOCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1085.31","1084.51035438","3.55","77","8","17","3","25","208.38","C56H73FN8O11S","InChI=1S/C56H73FN8O11S/c1-36-49(77-35-60-36)37-8-9-38(30-59-51(67)45-28-40(66)33-65(45)53(69)50(55(2,3)4)61-54(70)56(57)11-12-56)47(26-37)76-25-24-75-23-22-74-21-20-73-19-18-63-14-16-64(17-15-63)32-39-27-48(72-7)42(29-46(39)71-6)44-34-62(5)52(68)43-31-58-13-10-41(43)44/h8-10,13,26-27,29,31,34-35,40,45,50,66H,11-12,14-25,28,30,32-33H2,1-7H3,(H,59,67)(H,61,70)/t40-,45+,50-/m1/s1","BXWRRCUHAAQIEW-SHPBXJAASA-N"
"22","Q9H8M2","BRD9","VHL","","VZ185","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","1.76","95","Degradation of BRD9 in RI-1 cells after 8 h treatment","","","","","","","5.1","ITC","","","-11.35","-12.8","1.485","ITC","","","","","","","","","26/35","ITC/FP","","","-10.4","-7.04","-3.4","ITC","","","","","","","","","27/35","ITC/FP","","","-10.33","-5.1","-5.3","ITC between VHL and BRD9-BD:PROTAC","","","","","","","3/40","Inhibit proliferation of EOL-1/A-402 cells","","","","","","","0.01","Compounds were administered at 10000 nM and incubated for 5 h","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-26-37(63)29-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)43(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)31-41-44(68-6)24-36(25-45(41)69-7)40-30-59(5)49(65)39-28-55-16-13-38(39)40/h11-13,16,23-25,28,30,32,37,42,47,63H,8-10,14-15,17-22,26-27,29,31H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","ZAGCLFXBHOXXEN-JPTLTNPLSA-N"
"22","Q9H8M2","BRD9","VHL","","VZ185","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","4","","Degradation of HiBiT-BRD9 in HEK293 cells after 24 h treatment using CRISPR/Cas9","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-26-37(63)29-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)43(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)31-41-44(68-6)24-36(25-45(41)69-7)40-30-59(5)49(65)39-28-55-16-13-38(39)40/h11-13,16,23-25,28,30,32,37,42,47,63H,8-10,14-15,17-22,26-27,29,31H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","ZAGCLFXBHOXXEN-JPTLTNPLSA-N"
"22","Q9H8M2","BRD9","VHL","","VZ185","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","2/8","","Degradation of BRD9 in EOL-1/A-204 cells after 18 h treatment on a WES capillary electrophoresis instrument","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-26-37(63)29-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)43(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)31-41-44(68-6)24-36(25-45(41)69-7)40-30-59(5)49(65)39-28-55-16-13-38(39)40/h11-13,16,23-25,28,30,32,37,42,47,63H,8-10,14-15,17-22,26-27,29,31H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","ZAGCLFXBHOXXEN-JPTLTNPLSA-N"
"22","Q9NPI1","BRD7","VHL","","VZ185","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","4.5","95","Degradation of BRD7 in RI-1 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","26/35","ITC/FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3/40","Inhibit proliferation of EOL-1/A-402 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-26-37(63)29-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)43(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)31-41-44(68-6)24-36(25-45(41)69-7)40-30-59(5)49(65)39-28-55-16-13-38(39)40/h11-13,16,23-25,28,30,32,37,42,47,63H,8-10,14-15,17-22,26-27,29,31H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","ZAGCLFXBHOXXEN-JPTLTNPLSA-N"
"22","Q9NPI1","BRD7","VHL","","VZ185","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","34.5","","Degradation of HiBiT-BRD7 in HEK293 cells after 24 h treatment using CRISPR/Cas9","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-26-37(63)29-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)43(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)31-41-44(68-6)24-36(25-45(41)69-7)40-30-59(5)49(65)39-28-55-16-13-38(39)40/h11-13,16,23-25,28,30,32,37,42,47,63H,8-10,14-15,17-22,26-27,29,31H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","ZAGCLFXBHOXXEN-JPTLTNPLSA-N"
"23","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=C(OC)C=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-25-37(63)30-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)44(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)29-36-24-45(69-7)39(26-43(36)68-6)41-31-59(5)49(65)40-28-55-16-13-38(40)41/h11-13,16,23-24,26,28,31-32,37,42,47,63H,8-10,14-15,17-22,25,27,29-30H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","LTUULGOCMAXMHL-JPTLTNPLSA-N"
"23","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=C(OC)C=C1CN1CCN(CCCCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","995.232","994.478660324","5.06","71","8","14","3","19","180.69","C53H67FN8O8S","InChI=1S/C53H67FN8O8S/c1-33-46(71-32-57-33)34-11-12-35(27-56-48(64)42-25-37(63)30-62(42)50(66)47(52(2,3)4)58-51(67)53(54)14-15-53)44(23-34)70-22-10-8-9-17-60-18-20-61(21-19-60)29-36-24-45(69-7)39(26-43(36)68-6)41-31-59(5)49(65)40-28-55-16-13-38(40)41/h11-13,16,23-24,26,28,31-32,37,42,47,63H,8-10,14-15,17-22,25,27,29-30H2,1-7H3,(H,56,64)(H,58,67)/t37-,42+,47-/m1/s1","LTUULGOCMAXMHL-JPTLTNPLSA-N"
"24","Q9NPI1","BRD7","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1039.285","1038.50487507","4.91","74","8","15","3","22","189.92","C55H71FN8O9S","InChI=1S/C55H71FN8O9S/c1-35-48(74-34-59-35)36-11-12-37(29-58-50(66)44-28-39(65)31-64(44)52(68)49(54(2,3)4)60-53(69)55(56)14-15-55)45(25-36)73-24-23-72-22-10-8-9-17-62-18-20-63(21-19-62)33-43-46(70-6)26-38(27-47(43)71-7)42-32-61(5)51(67)41-30-57-16-13-40(41)42/h11-13,16,25-27,30,32,34,39,44,49,65H,8-10,14-15,17-24,28-29,31,33H2,1-7H3,(H,58,66)(H,60,69)/t39-,44+,49-/m1/s1","HFRKXDRNHGREGE-IHSWUNQZSA-N"
"24","Q9H8M2","BRD9","VHL","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CN1CCN(CCCCCOCCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01413","1039.285","1038.50487507","4.91","74","8","15","3","22","189.92","C55H71FN8O9S","InChI=1S/C55H71FN8O9S/c1-35-48(74-34-59-35)36-11-12-37(29-58-50(66)44-28-39(65)31-64(44)52(68)49(54(2,3)4)60-53(69)55(56)14-15-55)45(25-36)73-24-23-72-22-10-8-9-17-62-18-20-63(21-19-62)33-43-46(70-6)26-38(27-47(43)71-7)42-32-61(5)51(67)41-30-57-16-13-40(41)42/h11-13,16,25-27,30,32,34,39,44,49,65H,8-10,14-15,17-24,28-29,31,33H2,1-7H3,(H,58,66)(H,60,69)/t39-,44+,49-/m1/s1","HFRKXDRNHGREGE-IHSWUNQZSA-N"
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"41","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","894.788","893.250680264","5.71","63","9","9","6","10","194.91","C46H42Cl2FN7O7","InChI=1S/C46H42Cl2FN7O7/c47-25-13-16-29-32(23-25)53-44(63)46(29)36(28-8-4-9-30(48)37(28)49)38(55-45(46)19-2-1-3-20-45)41(60)52-26-14-11-24(12-15-26)39(58)51-22-6-21-50-31-10-5-7-27-35(31)43(62)56(42(27)61)33-17-18-34(57)54-40(33)59/h4-5,7-16,23,33,36,38,50,55H,1-3,6,17-22H2,(H,51,58)(H,52,60)(H,53,63)(H,54,57,59)/t33?,36-,38+,46+/m0/s1","ZIYFPOFVJLTNCT-PAOGXCKNSA-N"
"42","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","922.842","921.281980392","6.43","65","9","9","6","12","194.91","C48H46Cl2FN7O7","InChI=1S/C48H46Cl2FN7O7/c49-27-15-18-31-34(25-27)55-46(65)48(31)38(30-10-7-11-32(50)39(30)51)40(57-47(48)21-3-1-4-22-47)43(62)54-28-16-13-26(14-17-28)41(60)53-24-6-2-5-23-52-33-12-8-9-29-37(33)45(64)58(44(29)63)35-19-20-36(59)56-42(35)61/h7-18,25,35,38,40,52,57H,1-6,19-24H2,(H,53,60)(H,54,62)(H,55,65)(H,56,59,61)/t35?,38-,40+,48+/m0/s1","AFNPUWKPYMYQNM-XKCLGVMYSA-N"
"43","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","936.869","935.297630456","6.78","66","9","9","6","13","194.91","C49H48Cl2FN7O7","InChI=1S/C49H48Cl2FN7O7/c50-28-16-19-32-35(26-28)56-47(66)49(32)39(31-11-8-12-33(51)40(31)52)41(58-48(49)22-4-3-5-23-48)44(63)55-29-17-14-27(15-18-29)42(61)54-25-7-2-1-6-24-53-34-13-9-10-30-38(34)46(65)59(45(30)64)36-20-21-37(60)57-43(36)62/h8-19,26,36,39,41,53,58H,1-7,20-25H2,(H,54,61)(H,55,63)(H,56,66)(H,57,60,62)/t36?,39-,41+,49+/m0/s1","LHZJLSKTZYXVOP-KKOYIRLVSA-N"
"44","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","100","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","950.896","949.31328052","7.33","67","9","9","6","14","194.91","C50H50Cl2FN7O7","InChI=1S/C50H50Cl2FN7O7/c51-29-17-20-33-36(27-29)57-48(67)50(33)40(32-12-9-13-34(52)41(32)53)42(59-49(50)23-5-4-6-24-49)45(64)56-30-18-15-28(16-19-30)43(62)55-26-8-3-1-2-7-25-54-35-14-10-11-31-39(35)47(66)60(46(31)65)37-21-22-38(61)58-44(37)63/h9-20,27,37,40,42,54,59H,1-8,21-26H2,(H,55,62)(H,56,64)(H,57,67)(H,58,61,63)/t37?,40-,42+,50+/m0/s1","HMSPUEJTGLZJOV-KTORWNRRSA-N"
"45","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","924.814","923.261244948","5.21","65","9","10","6","12","204.14","C47H44Cl2FN7O8","InChI=1S/C47H44Cl2FN7O8/c48-26-12-15-30-33(24-26)54-45(64)47(30)37(29-7-4-8-31(49)38(29)50)39(56-46(47)18-2-1-3-19-46)42(61)53-27-13-10-25(11-14-27)40(59)52-21-23-65-22-20-51-32-9-5-6-28-36(32)44(63)57(43(28)62)34-16-17-35(58)55-41(34)60/h4-15,24,34,37,39,51,56H,1-3,16-23H2,(H,52,59)(H,53,61)(H,54,64)(H,55,58,60)/t34?,37-,39+,47+/m0/s1","KZOSJOUSNKCSJH-JUKLRSQZSA-N"
"46","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","1012.92","1011.31367444","4.91","71","9","12","6","18","222.6","C51H52Cl2FN7O10","InChI=1S/C51H52Cl2FN7O10/c52-30-12-15-34-37(28-30)58-49(68)51(34)41(33-7-4-8-35(53)42(33)54)43(60-50(51)18-2-1-3-19-50)46(65)57-31-13-10-29(11-14-31)44(63)56-21-23-70-25-27-71-26-24-69-22-20-55-36-9-5-6-32-40(36)48(67)61(47(32)66)38-16-17-39(62)59-45(38)64/h4-15,28,38,41,43,55,60H,1-3,16-27H2,(H,56,63)(H,57,65)(H,58,68)(H,59,62,64)/t38?,41-,43+,51+/m0/s1","NVNGUJITKUVBRM-KZGYOAQQSA-N"
"47","Q00987","MDM2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(CCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","29","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","907.827","906.27108136","6.34","64","9","8","5","11","182.88","C48H45Cl2FN6O7","InChI=1S/C48H45Cl2FN6O7/c49-28-16-19-32-34(25-28)54-46(64)48(32)38(31-12-8-13-33(50)39(31)51)40(56-47(48)22-4-2-5-23-47)43(61)53-29-17-14-27(15-18-29)41(59)52-24-6-1-3-9-26-10-7-11-30-37(26)45(63)57(44(30)62)35-20-21-36(58)55-42(35)60/h7-8,10-19,25,35,38,40,56H,1-6,9,20-24H2,(H,52,59)(H,53,61)(H,54,64)(H,55,58,60)/t35?,38-,40+,48+/m0/s1","GRHYYFNKDFGSAC-XKCLGVMYSA-N"
"48","Q00987","MDM2","CRBN","","","O=C1CCC(N2CC3=C(NCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","894.832","893.287065772","5.57","63","9","8","6","11","177.84","C47H46Cl2FN7O6","InChI=1S/C47H46Cl2FN7O6/c48-27-14-17-32-35(24-27)54-45(63)47(32)38(30-9-6-10-33(49)39(30)50)40(56-46(47)20-2-1-3-21-46)43(61)53-28-15-12-26(13-16-28)41(59)52-23-5-4-22-51-34-11-7-8-29-31(34)25-57(44(29)62)36-18-19-37(58)55-42(36)60/h6-17,24,36,38,40,51,56H,1-5,18-23,25H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t36?,38-,40+,47+/m0/s1","MPSBJBCNFUDFSX-FQWPNCNMSA-N"
"49","Q00987","MDM2","CRBN","","MD-222","O=C1CCC(N2CC3=C(CCCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.8","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","893.844","892.291816804","6.39","63","9","7","5","11","165.81","C48H47Cl2FN6O6","InChI=1S/C48H47Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-6,9,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1","RRSNDVCODIMOFX-MPKOGUQCSA-N"
"50","Q00987","MDM2","CRBN","","MD-224","O=C1CCC(N2CC3=C(C#CCCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.5","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","889.812","888.260516676","5.89","63","9","7","5","8","165.81","C48H43Cl2FN6O6","InChI=1S/C48H43Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-2,4-6,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1","ZLGNYFOIDAVMHY-MPKOGUQCSA-N"
"51","Q00987","MDM2","CRBN","","","O=C1CCC(N2CC3=C(C#CCCNC(=O)C4=CC=C(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)NC7=CC(Cl)=CC=C76)[C@H]5C5=CC=CC(Cl)=C5F)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.9","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00909","875.785","874.244866612","5.53","62","9","7","5","7","165.81","C47H41Cl2FN6O6","InChI=1S/C47H41Cl2FN6O6/c48-28-15-18-33-35(24-28)53-45(62)47(33)38(31-11-7-12-34(49)39(31)50)40(55-46(47)21-3-1-4-22-46)43(60)52-29-16-13-27(14-17-29)41(58)51-23-5-2-8-26-9-6-10-30-32(26)25-56(44(30)61)36-19-20-37(57)54-42(36)59/h6-7,9-18,24,36,38,40,55H,1,3-5,19-23,25H2,(H,51,58)(H,52,60)(H,53,62)(H,54,57,59)/t36?,38-,40+,47+/m0/s1","BTZJLLCRSYDNQG-FQWPNCNMSA-N"
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"107","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCN3CCN(C4=CC=C(C#CC5=CC=C(N6C(=S)N(C7=CC=C(C#N)C(C(F)(F)F)=C7)C(=O)C6(C)C)C=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","37/61/92","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1087.308","1086.42199171","8.22","77","8","12","3","13","178.34","C57H61F3N10O5S2","InChI=1S/C57H61F3N10O5S2/c1-35(39-15-17-40(18-16-39)49-36(2)63-34-77-49)64-51(73)46-30-44(71)33-68(46)52(74)50(55(3,4)5)65-48(72)9-8-24-66-25-27-67(28-26-66)47-23-14-38(32-62-47)11-10-37-12-20-42(21-13-37)70-54(76)69(53(75)56(70,6)7)43-22-19-41(31-61)45(29-43)57(58,59)60/h12-23,29,32,34-35,44,46,50,71H,8-9,24-28,30,33H2,1-7H3,(H,64,73)(H,65,72)/t35-,44+,46-,50+/m0/s1","UESVUNITXHBXAZ-RIZNWJGOSA-N"
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"109","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCN3CCN(C4=CC=C(C#CC5=CC=C(N6C(=S)N(C7=CC=C(C#N)C(C(F)(F)F)=C7)C(=O)C6(C)C)C=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","34/51/78","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1073.281","1072.40634165","7.87","76","8","12","3","12","178.34","C56H59F3N10O5S2","InChI=1S/C56H59F3N10O5S2/c1-34(38-13-15-39(16-14-38)48-35(2)62-33-76-48)63-50(72)45-29-43(70)32-67(45)51(73)49(54(3,4)5)64-47(71)22-23-65-24-26-66(27-25-65)46-21-12-37(31-61-46)9-8-36-10-18-41(19-11-36)69-53(75)68(52(74)55(69,6)7)42-20-17-40(30-60)44(28-42)56(57,58)59/h10-21,28,31,33-34,43,45,49,70H,22-27,29,32H2,1-7H3,(H,63,72)(H,64,71)/t34-,43+,45-,49+/m0/s1","XBYIKVWSXKAVDE-KQDFWKMASA-N"
"110","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CN3CCN(C4=CC=C(C#CC5=CC=C(N6C(=S)N(C7=CC=C(C#N)C(C(F)(F)F)=C7)C(=O)C6(C)C)C=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","3/31/28","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1059.254","1058.39069158","7.96","75","8","12","3","11","178.34","C55H57F3N10O5S2","InChI=1S/C55H57F3N10O5S2/c1-33(37-13-15-38(16-14-37)47-34(2)61-32-75-47)62-49(71)44-27-42(69)30-66(44)50(72)48(53(3,4)5)63-46(70)31-64-22-24-65(25-23-64)45-21-12-36(29-60-45)9-8-35-10-18-40(19-11-35)68-52(74)67(51(73)54(68,6)7)41-20-17-39(28-59)43(26-41)55(56,57)58/h10-21,26,29,32-33,42,44,48,69H,22-25,27,30-31H2,1-7H3,(H,62,71)(H,63,70)/t33-,42+,44-,48+/m0/s1","XVQSTGFWUADNSG-ZYBUMLIXSA-N"
"111","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)N3CCN(C4=CC=C(C#CC5=CC=C(N6C(=S)N(C7=CC=C(C#N)C(C(F)(F)F)=C7)C(=O)C6(C)C)C=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","0/12/0","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1045.227","1044.37504152","7.91","74","8","11","3","9","178.34","C54H55F3N10O5S2","InChI=1S/C54H55F3N10O5S2/c1-32(36-13-15-37(16-14-36)45-33(2)60-31-74-45)61-47(69)43-27-41(68)30-65(43)48(70)46(52(3,4)5)62-50(72)64-24-22-63(23-25-64)44-21-12-35(29-59-44)9-8-34-10-18-39(19-11-34)67-51(73)66(49(71)53(67,6)7)40-20-17-38(28-58)42(26-40)54(55,56)57/h10-21,26,29,31-32,41,43,46,68H,22-25,27,30H2,1-7H3,(H,61,69)(H,62,72)/t32-,41+,43-,46+/m0/s1","DZDNEYFUVBHXKM-GNXBVMDESA-N"
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"114","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCN(C3=CC=C(C#CC4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)C=N3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","22/72/93","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1097.259","1096.36995614","7.7","78","9","13","2","12","192.34","C57H55F3N10O6S2","InChI=1S/C57H55F3N10O6S2/c1-33(2)50(47-25-34(3)65-76-47)53(74)68-31-43(71)27-46(68)52(73)64-45(38-12-14-39(15-13-38)51-35(4)63-32-78-51)28-49(72)67-23-21-66(22-24-67)48-20-11-37(30-62-48)8-7-36-9-17-41(18-10-36)70-55(77)69(54(75)56(70,5)6)42-19-16-40(29-61)44(26-42)57(58,59)60/h9-20,25-26,30,32-33,43,45-46,50,71H,21-24,27-28,31H2,1-6H3,(H,64,73)/t43-,45+,46+,50-/m1/s1","IQMQOGXOGASOHR-WWWWNMQMSA-N"
"115","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","20/81/97","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1102.319","1101.42165736","8.04","78","9","12","2","12","179.45","C58H62F3N9O6S2","InChI=1S/C58H62F3N9O6S2/c1-34(2)51(49-27-35(3)65-76-49)54(74)68-32-45(71)29-48(68)53(73)64-47(39-11-13-40(14-12-39)52-36(4)63-33-78-52)30-50(72)67-25-21-42(22-26-67)66-23-19-38(20-24-66)8-7-37-9-16-43(17-10-37)70-56(77)69(55(75)57(70,5)6)44-18-15-41(31-62)46(28-44)58(59,60)61/h9-18,27-28,33-34,38,42,45,47-48,51,71H,19-26,29-30,32H2,1-6H3,(H,64,73)/t45-,47+,48+,51-/m1/s1","GUBNYKHHDKQDQF-CIFRGWANSA-N"
"116","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(N5C(=S)N(C6=CN=C(C#N)C(C(F)(F)F)=C6)C(=O)C56CCC6)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","38/80/95","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1115.318","1114.41690633","7.42","79","10","13","2","12","192.34","C58H61F3N10O6S2","InChI=1S/C58H61F3N10O6S2/c1-34(2)51(49-26-35(3)66-77-49)54(75)69-32-44(72)28-48(69)53(74)65-46(39-10-12-40(13-11-39)52-36(4)64-33-79-52)29-50(73)68-24-18-41(19-25-68)67-22-16-38(17-23-67)7-6-37-8-14-42(15-9-37)71-56(78)70(55(76)57(71)20-5-21-57)43-27-45(58(59,60)61)47(30-62)63-31-43/h8-15,26-27,31,33-34,38,41,44,46,48,51,72H,5,16-25,28-29,32H2,1-4H3,(H,65,74)/t44-,46+,48+,51-/m1/s1","ALWGZTAGCPHDFO-YUWVYYDQSA-N"
"117","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(S(=O)CC(C)(O)C(=O)NC5=CC=C(C#N)C(C(F)(F)F)=C5)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","18/34/35","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1109.307","1108.41623764","5.84","78","8","13","4","15","222.3","C57H63F3N8O8S2","InChI=1S/C57H63F3N8O8S2/c1-34(2)51(49-26-35(3)65-76-49)54(72)68-31-44(69)28-48(68)53(71)64-47(39-10-12-40(13-11-39)52-36(4)62-33-77-52)29-50(70)67-24-20-43(21-25-67)66-22-18-38(19-23-66)7-6-37-8-16-45(17-9-37)78(75)32-56(5,74)55(73)63-42-15-14-41(30-61)46(27-42)57(58,59)60/h8-17,26-27,33-34,38,43-44,47-48,51,69,74H,18-25,28-29,31-32H2,1-5H3,(H,63,73)(H,64,71)/t44-,47+,48+,51-,56?,78?/m1/s1","XJIMCYXRPLNZMP-NKZBRKBLSA-N"
"118","P10275","AR","VHL","","ARD-61","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","76/98/99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1095.808","1094.48549529","9.31","78","9","12","3","14","194.23","C61H71ClN8O7S","InChI=1S/C61H71ClN8O7S/c1-36(2)53(51-29-37(3)67-77-51)57(75)70-34-46(71)30-50(70)56(74)65-49(41-15-17-42(18-16-41)54-38(4)64-35-78-54)32-52(72)69-27-23-45(24-28-69)68-25-21-40(22-26-68)10-9-39-11-13-43(14-12-39)55(73)66-58-60(5,6)59(61(58,7)8)76-47-20-19-44(33-63)48(62)31-47/h11-20,29,31,35-36,40,45-46,49-50,53,58-59,71H,21-28,30,32,34H2,1-8H3,(H,65,74)(H,66,73)/t46-,49+,50+,53-,58-,59-/m1/s1","RGPUSLXMPBTXNU-MLMZQBPXSA-N"
"118","P10275","AR","VHL","","ARD-61","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","7.2/1",">95/>95","Degradation of AR in LNCaP/VCaP AR+ cells after 6 h treatment","76/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2/2","Inhibit growth of LNCaP/VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1095.808","1094.48549529","9.31","78","9","12","3","14","194.23","C61H71ClN8O7S","InChI=1S/C61H71ClN8O7S/c1-36(2)53(51-29-37(3)67-77-51)57(75)70-34-46(71)30-50(70)56(74)65-49(41-15-17-42(18-16-41)54-38(4)64-35-78-54)32-52(72)69-27-23-45(24-28-69)68-25-21-40(22-26-68)10-9-39-11-13-43(14-12-39)55(73)66-58-60(5,6)59(61(58,7)8)76-47-20-19-44(33-63)48(62)31-47/h11-20,29,31,35-36,40,45-46,49-50,53,58-59,71H,21-28,30,32,34H2,1-8H3,(H,65,74)(H,66,73)/t46-,49+,50+,53-,58-,59-/m1/s1","RGPUSLXMPBTXNU-MLMZQBPXSA-N"
"119","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(CC5=C(C)N(C6=CC=C(C#N)C(Cl)=C6)N=C5C)C=C4)CC3)CC2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","65/93/78","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1034.728","1033.44396483","8.77","74","9","12","2","13","173.72","C58H64ClN9O5S","InChI=1S/C58H64ClN9O5S/c1-35(2)55(53-27-36(3)64-73-53)58(72)67-33-48(69)30-52(67)57(71)62-51(43-13-15-44(16-14-43)56-38(5)61-34-74-56)31-54(70)66-25-21-46(22-26-66)65-23-19-41(20-24-65)8-7-40-9-11-42(12-10-40)28-49-37(4)63-68(39(49)6)47-18-17-45(32-60)50(59)29-47/h9-18,27,29,34-35,41,46,48,51-52,55,69H,19-26,28,30-31,33H2,1-6H3,(H,62,71)/t48-,51+,52+,55-/m1/s1","STEVDPTZCIOYTQ-SFWKOQDQSA-N"
"120","P10275","AR","VHL","","ARD-69","CC1=C(C2=CC=C([C@H](CC(=O)N3CCC(N4CCC(C#CC5=CC=C(C(=O)N[C@H]6C(C)(C)[C@H](OC7=CC=C(C#N)C(Cl)=C7)C6(C)C)C=C5)CC4)CC3)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C=C2)SC=N1","0.86/0.76/10.4",">95/>95/>95","Degradation of AR in LNCaP/VCaP/22Rv1 cells after 24 h treatment","89/99/100","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.25/0.34/183","Inhibit growth of LNCaP/VCaP/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1129.841","1128.50737361","9.29","80","9","11","4","14","197.3","C62H74ClFN8O7S","InChI=1S/C62H74ClFN8O7S/c1-37-51(80-36-66-37)41-17-15-40(16-18-41)48(67-54(76)49-31-45(73)35-72(49)55(77)52(59(2,3)4)68-58(78)62(64)25-26-62)33-50(74)71-29-23-44(24-30-71)70-27-21-39(22-28-70)10-9-38-11-13-42(14-12-38)53(75)69-56-60(5,6)57(61(56,7)8)79-46-20-19-43(34-65)47(63)32-46/h11-20,32,36,39,44-45,48-49,52,56-57,73H,21-31,33,35H2,1-8H3,(H,67,76)(H,68,78)(H,69,75)/t45-,48+,49+,52-,56-,57-/m1/s1","CWGVEMFBQJUWLU-RXFAPWBBSA-N"
"121","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](CC(=O)N3CCC(N4CCC(C#CC5=CC=C(C(=O)N[C@H]6C(C)(C)[C@H](OC7=CC=C(C#N)C(Cl)=C7)C6(C)C)C=C5)CC4)CC3)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(C#N)CC3)C(C)(C)C)C=C2)SC=N1","","","","76/99/100","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1136.861","1135.51204439","8.81","81","9","12","4","14","221.09","C63H74ClN9O7S","InChI=1S/C63H74ClN9O7S/c1-38-52(81-37-67-38)42-17-15-41(16-18-42)49(68-55(77)50-31-46(74)35-73(50)56(78)53(60(2,3)4)69-59(79)63(36-66)25-26-63)33-51(75)72-29-23-45(24-30-72)71-27-21-40(22-28-71)10-9-39-11-13-43(14-12-39)54(76)70-57-61(5,6)58(62(57,7)8)80-47-20-19-44(34-65)48(64)32-47/h11-20,32,37,40,45-46,49-50,53,57-58,74H,21-31,33,35H2,1-8H3,(H,68,77)(H,69,79)(H,70,76)/t46-,49+,50+,53-,57-,58-/m1/s1","YLIIPOUNLYQGIU-NMPLUEPVSA-N"
"122","P10275","AR","VHL","","","CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(N2CCC(C#CC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(Cl)=C5)C4(C)C)C=C3)CC2)CC1)C1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","39/77/99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1085.813","1084.50114536","8.57","77","8","11","4","13","197.3","C60H73ClN8O7S","InChI=1S/C60H73ClN8O7S/c1-36-51(77-35-63-36)41-18-16-40(17-19-41)48(65-54(74)49-30-45(71)34-69(49)55(75)52(58(3,4)5)64-37(2)70)32-50(72)68-28-24-44(25-29-68)67-26-22-39(23-27-67)11-10-38-12-14-42(15-13-38)53(73)66-56-59(6,7)57(60(56,8)9)76-46-21-20-43(33-62)47(61)31-46/h12-21,31,35,39,44-45,48-49,52,56-57,71H,22-30,32,34H2,1-9H3,(H,64,70)(H,65,74)(H,66,73)/t45-,48+,49+,52-,56-,57-/m1/s1","YCVBOGOSHGKMCU-RXFAPWBBSA-N"
"123","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@@H](CC(=O)N3CCC(N4CCC(C#CC5=CC=C(C(=O)N[C@H]6C(C)(C)[C@H](OC7=CC=C(C#N)C(Cl)=C7)C6(C)C)C=C5)CC4)CC3)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C=C2)SC=N1","","","","<5/<5/<5","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1129.841","1128.50737361","9.29","80","9","11","4","14","197.3","C62H74ClFN8O7S","InChI=1S/C62H74ClFN8O7S/c1-37-51(80-36-66-37)41-17-15-40(16-18-41)48(67-54(76)49-31-45(73)35-72(49)55(77)52(59(2,3)4)68-58(78)62(64)25-26-62)33-50(74)71-29-23-44(24-30-71)70-27-21-39(22-28-70)10-9-38-11-13-42(14-12-38)53(75)69-56-60(5,6)57(61(56,7)8)79-46-20-19-43(34-65)47(63)32-46/h11-20,32,36,39,44-45,48-49,52,56-57,73H,21-31,33,35H2,1-8H3,(H,67,76)(H,68,78)(H,69,75)/t45-,48-,49+,52-,56-,57-/m1/s1","CWGVEMFBQJUWLU-QNUMSGHZSA-N"
"124","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](CC(=O)N3CCC(N4CCC(C#CC5=CC=C(C(=O)N[C@H]6C(C)(C)[C@H](OC7=CC=C(C#N)C(Cl)=C7)C6(C)C)C=C5)CC4)CC3)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](NC(=O)C3(F)CC3)C(C)(C)C)C=C2)SC=N1","","","","<5/<5/<5","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1129.841","1128.50737361","9.29","80","9","11","4","14","197.3","C62H74ClFN8O7S","InChI=1S/C62H74ClFN8O7S/c1-37-51(80-36-66-37)41-17-15-40(16-18-41)48(67-54(76)49-31-45(73)35-72(49)55(77)52(59(2,3)4)68-58(78)62(64)25-26-62)33-50(74)71-29-23-44(24-30-71)70-27-21-39(22-28-70)10-9-38-11-13-42(14-12-38)53(75)69-56-60(5,6)57(61(56,7)8)79-46-20-19-43(34-65)47(63)32-46/h11-20,32,36,39,44-45,48-49,52,56-57,73H,21-31,33,35H2,1-8H3,(H,67,76)(H,68,78)(H,69,75)/t45-,48+,49+,52+,56-,57-/m1/s1","CWGVEMFBQJUWLU-LIZFVIDXSA-N"
"125","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)NCCCCCCCCCNC(=O)C2=CC=C(C(=O)N[C@H]3C(C)(C)[C@H](OC4=CC=C(C#N)C(Cl)=C4)C3(C)C)C=C2)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)C)=C1","","","","43/91/96","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","1089.801","1088.49605998","9.93","77","7","12","5","24","228.88","C59H73ClN8O8S","InChI=1S/C59H73ClN8O8S/c1-35(2)50(48-28-36(3)67-76-48)55(74)68-33-43(69)29-47(68)54(73)65-46(38-16-18-39(19-17-38)51-37(4)64-34-77-51)31-49(70)62-26-14-12-10-9-11-13-15-27-63-52(71)40-20-22-41(23-21-40)53(72)66-56-58(5,6)57(59(56,7)8)75-44-25-24-42(32-61)45(60)30-44/h16-25,28,30,34-35,43,46-47,50,56-57,69H,9-15,26-27,29,31,33H2,1-8H3,(H,62,70)(H,63,71)(H,65,73)(H,66,72)/t43-,46+,47+,50-,56-,57-/m1/s1","UTPTUYDLZXJLRV-NKRIERETSA-N"
"126","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C(=O)NCCCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","7/20/5","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","837.418","836.366425716","8.8","60","6","9","4","18","186.8","C46H53ClN6O7","InChI=1S/C46H53ClN6O7/c1-45(2)43(46(3,4)44(45)60-31-21-20-30(27-48)33(47)26-31)52-39(56)29-18-16-28(17-19-29)38(55)50-25-12-10-8-6-5-7-9-11-24-49-34-15-13-14-32-37(34)42(59)53(41(32)58)35-22-23-36(54)51-40(35)57/h13-21,26,35,43-44,49H,5-12,22-25H2,1-4H3,(H,50,55)(H,52,56)(H,51,54,57)/t35?,43-,44-","QRQGVXVDQXIEQK-OBASXCCISA-N"
"127","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C#CC3CCN(C4CCN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","2/25/20","% AR degradation in LNCaP cells after 6 h treatment at 100/1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01631","829.398","828.340210968","7.05","60","8","9","2","7","152.15","C47H49ClN6O6","InChI=1S/C47H49ClN6O6/c1-46(2)44(47(3,4)45(46)60-33-15-14-31(27-49)35(48)26-33)51-40(56)30-12-10-28(11-13-30)8-9-29-18-22-52(23-19-29)32-20-24-53(25-21-32)36-7-5-6-34-39(36)43(59)54(42(34)58)37-16-17-38(55)50-41(37)57/h5-7,10-15,26,29,32,37,44-45H,16-25H2,1-4H3,(H,51,56)(H,50,55,57)/t37?,44-,45-","JFDLNPIBQDRWHM-FMQKDUAYSA-N"
"128","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.3/45.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","871.912","871.34017202","3.78","64","9","15","5","16","257.66","C44H45N11O9","InChI=1S/C44H45N11O9/c1-5-54-32(19-27(52-54)23-11-12-23)48-39-37-25-18-31(62-4)26(35-21(2)53-64-22(35)3)17-28(25)47-38(37)50-40(51-39)42(59)46-16-7-6-15-45-34(57)20-63-30-10-8-9-24-36(30)44(61)55(43(24)60)29-13-14-33(56)49-41(29)58/h8-10,17-19,23,29H,5-7,11-16,20H2,1-4H3,(H,45,57)(H,46,59)(H,49,56,58)(H2,47,48,50,51)","TXLUZGFDBDQACL-UHFFFAOYSA-N"
"128","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.3/45.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","871.912","871.34017202","3.78","64","9","15","5","16","257.66","C44H45N11O9","InChI=1S/C44H45N11O9/c1-5-54-32(19-27(52-54)23-11-12-23)48-39-37-25-18-31(62-4)26(35-21(2)53-64-22(35)3)17-28(25)47-38(37)50-40(51-39)42(59)46-16-7-6-15-45-34(57)20-63-30-10-8-9-24-36(30)44(61)55(43(24)60)29-13-14-33(56)49-41(29)58/h8-10,17-19,23,29H,5-7,11-16,20H2,1-4H3,(H,45,57)(H,46,59)(H,49,56,58)(H2,47,48,50,51)","TXLUZGFDBDQACL-UHFFFAOYSA-N"
"128","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.3/45.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","871.912","871.34017202","3.78","64","9","15","5","16","257.66","C44H45N11O9","InChI=1S/C44H45N11O9/c1-5-54-32(19-27(52-54)23-11-12-23)48-39-37-25-18-31(62-4)26(35-21(2)53-64-22(35)3)17-28(25)47-38(37)50-40(51-39)42(59)46-16-7-6-15-45-34(57)20-63-30-10-8-9-24-36(30)44(61)55(43(24)60)29-13-14-33(56)49-41(29)58/h8-10,17-19,23,29H,5-7,11-16,20H2,1-4H3,(H,45,57)(H,46,59)(H,49,56,58)(H2,47,48,50,51)","TXLUZGFDBDQACL-UHFFFAOYSA-N"
"129","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.5/19.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","870.928","870.356156432","4.35","64","9","15","6","16","260.46","C44H46N12O8","InChI=1S/C44H46N12O8/c1-5-55-32(19-28(53-55)23-11-12-23)49-39-37-25-18-31(63-4)26(35-21(2)54-64-22(35)3)17-29(25)48-38(37)51-40(52-39)42(60)46-16-7-6-15-45-34(58)20-47-27-10-8-9-24-36(27)44(62)56(43(24)61)30-13-14-33(57)50-41(30)59/h8-10,17-19,23,30,47H,5-7,11-16,20H2,1-4H3,(H,45,58)(H,46,60)(H,50,57,59)(H2,48,49,51,52)","JZUWVOKWDMEWLL-UHFFFAOYSA-N"
"129","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.5/19.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","870.928","870.356156432","4.35","64","9","15","6","16","260.46","C44H46N12O8","InChI=1S/C44H46N12O8/c1-5-55-32(19-28(53-55)23-11-12-23)49-39-37-25-18-31(63-4)26(35-21(2)54-64-22(35)3)17-29(25)48-38(37)51-40(52-39)42(60)46-16-7-6-15-45-34(58)20-47-27-10-8-9-24-36(27)44(62)56(43(24)61)30-13-14-33(57)50-41(30)59/h8-10,17-19,23,30,47H,5-7,11-16,20H2,1-4H3,(H,45,58)(H,46,60)(H,50,57,59)(H2,48,49,51,52)","JZUWVOKWDMEWLL-UHFFFAOYSA-N"
"129","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.5/19.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","870.928","870.356156432","4.35","64","9","15","6","16","260.46","C44H46N12O8","InChI=1S/C44H46N12O8/c1-5-55-32(19-28(53-55)23-11-12-23)49-39-37-25-18-31(63-4)26(35-21(2)54-64-22(35)3)17-29(25)48-38(37)51-40(52-39)42(60)46-16-7-6-15-45-34(58)20-47-27-10-8-9-24-36(27)44(62)56(43(24)61)30-13-14-33(57)50-41(30)59/h8-10,17-19,23,30,47H,5-7,11-16,20H2,1-4H3,(H,45,58)(H,46,60)(H,50,57,59)(H2,48,49,51,52)","JZUWVOKWDMEWLL-UHFFFAOYSA-N"
"130","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.48/3.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","856.941","856.365658496","5.69","63","9","14","4","17","228.56","C45H48N10O8","InChI=1S/C45H48N10O8/c1-5-54-34(22-29(52-54)25-14-15-25)48-40-38-27-21-33(61-4)28(36-23(2)53-63-24(36)3)20-30(27)47-39(38)50-41(51-40)43(58)46-18-9-7-6-8-10-19-62-32-13-11-12-26-37(32)45(60)55(44(26)59)31-16-17-35(56)49-42(31)57/h11-13,20-22,25,31H,5-10,14-19H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","OFIGJQVJFADAFV-UHFFFAOYSA-N"
"130","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.48/3.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","856.941","856.365658496","5.69","63","9","14","4","17","228.56","C45H48N10O8","InChI=1S/C45H48N10O8/c1-5-54-34(22-29(52-54)25-14-15-25)48-40-38-27-21-33(61-4)28(36-23(2)53-63-24(36)3)20-30(27)47-39(38)50-41(51-40)43(58)46-18-9-7-6-8-10-19-62-32-13-11-12-26-37(32)45(60)55(44(26)59)31-16-17-35(56)49-42(31)57/h11-13,20-22,25,31H,5-10,14-19H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","OFIGJQVJFADAFV-UHFFFAOYSA-N"
"130","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.48/3.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","856.941","856.365658496","5.69","63","9","14","4","17","228.56","C45H48N10O8","InChI=1S/C45H48N10O8/c1-5-54-34(22-29(52-54)25-14-15-25)48-40-38-27-21-33(61-4)28(36-23(2)53-63-24(36)3)20-30(27)47-39(38)50-41(51-40)43(58)46-18-9-7-6-8-10-19-62-32-13-11-12-26-37(32)45(60)55(44(26)59)31-16-17-35(56)49-42(31)57/h11-13,20-22,25,31H,5-10,14-19H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","OFIGJQVJFADAFV-UHFFFAOYSA-N"
"131","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.2/1.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","855.957","855.381642908","6.26","63","9","14","5","17","231.36","C45H49N11O7","InChI=1S/C45H49N11O7/c1-5-55-34(22-30(53-55)25-14-15-25)49-40-38-27-21-33(62-4)28(36-23(2)54-63-24(36)3)20-31(27)48-39(38)51-41(52-40)43(59)47-19-10-8-6-7-9-18-46-29-13-11-12-26-37(29)45(61)56(44(26)60)32-16-17-35(57)50-42(32)58/h11-13,20-22,25,32,46H,5-10,14-19H2,1-4H3,(H,47,59)(H,50,57,58)(H2,48,49,51,52)","NQUBBBPLONXGFF-UHFFFAOYSA-N"
"131","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.2/1.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","855.957","855.381642908","6.26","63","9","14","5","17","231.36","C45H49N11O7","InChI=1S/C45H49N11O7/c1-5-55-34(22-30(53-55)25-14-15-25)49-40-38-27-21-33(62-4)28(36-23(2)54-63-24(36)3)20-31(27)48-39(38)51-41(52-40)43(59)47-19-10-8-6-7-9-18-46-29-13-11-12-26-37(29)45(61)56(44(26)60)32-16-17-35(57)50-42(32)58/h11-13,20-22,25,32,46H,5-10,14-19H2,1-4H3,(H,47,59)(H,50,57,58)(H2,48,49,51,52)","NQUBBBPLONXGFF-UHFFFAOYSA-N"
"131","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.2/1.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","855.957","855.381642908","6.26","63","9","14","5","17","231.36","C45H49N11O7","InChI=1S/C45H49N11O7/c1-5-55-34(22-30(53-55)25-14-15-25)49-40-38-27-21-33(62-4)28(36-23(2)54-63-24(36)3)20-31(27)48-39(38)51-41(52-40)43(59)47-19-10-8-6-7-9-18-46-29-13-11-12-26-37(29)45(61)56(44(26)60)32-16-17-35(57)50-42(32)58/h11-13,20-22,25,32,46H,5-10,14-19H2,1-4H3,(H,47,59)(H,50,57,58)(H2,48,49,51,52)","NQUBBBPLONXGFF-UHFFFAOYSA-N"
"132","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.63/3.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","841.93","841.365992844","5.72","62","9","14","5","16","231.36","C44H47N11O7","InChI=1S/C44H47N11O7/c1-5-54-33(21-29(52-54)24-13-14-24)48-39-37-26-20-32(61-4)27(35-22(2)53-62-23(35)3)19-30(26)47-38(37)50-40(51-39)42(58)46-18-9-7-6-8-17-45-28-12-10-11-25-36(28)44(60)55(43(25)59)31-15-16-34(56)49-41(31)57/h10-12,19-21,24,31,45H,5-9,13-18H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","SARABRPDROBMJB-UHFFFAOYSA-N"
"132","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.63/3.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","841.93","841.365992844","5.72","62","9","14","5","16","231.36","C44H47N11O7","InChI=1S/C44H47N11O7/c1-5-54-33(21-29(52-54)24-13-14-24)48-39-37-26-20-32(61-4)27(35-22(2)53-62-23(35)3)19-30(26)47-38(37)50-40(51-39)42(58)46-18-9-7-6-8-17-45-28-12-10-11-25-36(28)44(60)55(43(25)59)31-15-16-34(56)49-41(31)57/h10-12,19-21,24,31,45H,5-9,13-18H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","SARABRPDROBMJB-UHFFFAOYSA-N"
"132","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.63/3.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","841.93","841.365992844","5.72","62","9","14","5","16","231.36","C44H47N11O7","InChI=1S/C44H47N11O7/c1-5-54-33(21-29(52-54)24-13-14-24)48-39-37-26-20-32(61-4)27(35-22(2)53-62-23(35)3)19-30(26)47-38(37)50-40(51-39)42(58)46-18-9-7-6-8-17-45-28-12-10-11-25-36(28)44(60)55(43(25)59)31-15-16-34(56)49-41(31)57/h10-12,19-21,24,31,45H,5-9,13-18H2,1-4H3,(H,46,58)(H,49,56,57)(H2,47,48,50,51)","SARABRPDROBMJB-UHFFFAOYSA-N"
"133","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","827.903","827.35034278","5.36","61","9","14","5","15","231.36","C43H45N11O7","InChI=1S/C43H45N11O7/c1-5-53-32(20-28(51-53)23-12-13-23)47-38-36-25-19-31(60-4)26(34-21(2)52-61-22(34)3)18-29(25)46-37(36)49-39(50-38)41(57)45-17-8-6-7-16-44-27-11-9-10-24-35(27)43(59)54(42(24)58)30-14-15-33(55)48-40(30)56/h9-11,18-20,23,30,44H,5-8,12-17H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","XNEXUBXOTMSNMZ-UHFFFAOYSA-N"
"133","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","827.903","827.35034278","5.36","61","9","14","5","15","231.36","C43H45N11O7","InChI=1S/C43H45N11O7/c1-5-53-32(20-28(51-53)23-12-13-23)47-38-36-25-19-31(60-4)26(34-21(2)52-61-22(34)3)18-29(25)46-37(36)49-39(50-38)41(57)45-17-8-6-7-16-44-27-11-9-10-24-35(27)43(59)54(42(24)58)30-14-15-33(55)48-40(30)56/h9-11,18-20,23,30,44H,5-8,12-17H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","XNEXUBXOTMSNMZ-UHFFFAOYSA-N"
"133","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","827.903","827.35034278","5.36","61","9","14","5","15","231.36","C43H45N11O7","InChI=1S/C43H45N11O7/c1-5-53-32(20-28(51-53)23-12-13-23)47-38-36-25-19-31(60-4)26(34-21(2)52-61-22(34)3)18-29(25)46-37(36)49-39(50-38)41(57)45-17-8-6-7-16-44-27-11-9-10-24-35(27)43(59)54(42(24)58)30-14-15-33(55)48-40(30)56/h9-11,18-20,23,30,44H,5-8,12-17H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","XNEXUBXOTMSNMZ-UHFFFAOYSA-N"
"134","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.45/5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","813.876","813.334692716","5.0","60","9","14","5","14","231.36","C42H43N11O7","InChI=1S/C42H43N11O7/c1-5-52-31(19-27(50-52)22-11-12-22)46-37-35-24-18-30(59-4)25(33-20(2)51-60-21(33)3)17-28(24)45-36(35)48-38(49-37)40(56)44-16-7-6-15-43-26-10-8-9-23-34(26)42(58)53(41(23)57)29-13-14-32(54)47-39(29)55/h8-10,17-19,22,29,43H,5-7,11-16H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","MBZZRTJPOGHANP-UHFFFAOYSA-N"
"134","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.45/5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","813.876","813.334692716","5.0","60","9","14","5","14","231.36","C42H43N11O7","InChI=1S/C42H43N11O7/c1-5-52-31(19-27(50-52)22-11-12-22)46-37-35-24-18-30(59-4)25(33-20(2)51-60-21(33)3)17-28(24)45-36(35)48-38(49-37)40(56)44-16-7-6-15-43-26-10-8-9-23-34(26)42(58)53(41(23)57)29-13-14-32(54)47-39(29)55/h8-10,17-19,22,29,43H,5-7,11-16H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","MBZZRTJPOGHANP-UHFFFAOYSA-N"
"134","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.45/5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","813.876","813.334692716","5.0","60","9","14","5","14","231.36","C42H43N11O7","InChI=1S/C42H43N11O7/c1-5-52-31(19-27(50-52)22-11-12-22)46-37-35-24-18-30(59-4)25(33-20(2)51-60-21(33)3)17-28(24)45-36(35)48-38(49-37)40(56)44-16-7-6-15-43-26-10-8-9-23-34(26)42(58)53(41(23)57)29-13-14-32(54)47-39(29)55/h8-10,17-19,22,29,43H,5-7,11-16H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","MBZZRTJPOGHANP-UHFFFAOYSA-N"
"135","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.4/9.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","799.849","799.319042652","4.65","59","9","14","5","13","231.36","C41H41N11O7","InChI=1S/C41H41N11O7/c1-5-51-30(18-26(49-51)21-10-11-21)45-36-34-23-17-29(58-4)24(32-19(2)50-59-20(32)3)16-27(23)44-35(34)47-37(48-36)39(55)43-15-7-14-42-25-9-6-8-22-33(25)41(57)52(40(22)56)28-12-13-31(53)46-38(28)54/h6,8-9,16-18,21,28,42H,5,7,10-15H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","KMZUDVVTKSNKQQ-UHFFFAOYSA-N"
"135","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.4/9.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","799.849","799.319042652","4.65","59","9","14","5","13","231.36","C41H41N11O7","InChI=1S/C41H41N11O7/c1-5-51-30(18-26(49-51)21-10-11-21)45-36-34-23-17-29(58-4)24(32-19(2)50-59-20(32)3)16-27(23)44-35(34)47-37(48-36)39(55)43-15-7-14-42-25-9-6-8-22-33(25)41(57)52(40(22)56)28-12-13-31(53)46-38(28)54/h6,8-9,16-18,21,28,42H,5,7,10-15H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","KMZUDVVTKSNKQQ-UHFFFAOYSA-N"
"135","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.4/9.5","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","799.849","799.319042652","4.65","59","9","14","5","13","231.36","C41H41N11O7","InChI=1S/C41H41N11O7/c1-5-51-30(18-26(49-51)21-10-11-21)45-36-34-23-17-29(58-4)24(32-19(2)50-59-20(32)3)16-27(23)44-35(34)47-37(48-36)39(55)43-15-7-14-42-25-9-6-8-22-33(25)41(57)52(40(22)56)28-12-13-31(53)46-38(28)54/h6,8-9,16-18,21,28,42H,5,7,10-15H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","KMZUDVVTKSNKQQ-UHFFFAOYSA-N"
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"138","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCOCCCC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.42/5.9","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","828.887","828.334358368","4.22","61","9","14","4","15","228.56","C43H44N10O8","InChI=1S/C43H44N10O8/c1-5-52-32(20-28(50-52)23-11-12-23)46-38-36-26-19-31(59-4)27(34-21(2)51-61-22(34)3)18-29(26)45-37(36)48-39(49-38)41(56)44-15-17-60-16-7-9-24-8-6-10-25-35(24)43(58)53(42(25)57)30-13-14-33(54)47-40(30)55/h6,8,10,18-20,23,30H,5,7,9,11-17H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","MALUPIJSHNCOFX-UHFFFAOYSA-N"
"139","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.888","812.339443748","5.27","60","9","13","4","14","219.33","C43H44N10O7","InChI=1S/C43H44N10O7/c1-5-52-32(20-28(50-52)23-13-14-23)46-38-36-26-19-31(59-4)27(34-21(2)51-60-22(34)3)18-29(26)45-37(36)48-39(49-38)41(56)44-17-8-6-7-10-24-11-9-12-25-35(24)43(58)53(42(25)57)30-15-16-33(54)47-40(30)55/h9,11-12,18-20,23,30H,5-8,10,13-17H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","USXQCAQGOVVSTI-UHFFFAOYSA-N"
"139","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.888","812.339443748","5.27","60","9","13","4","14","219.33","C43H44N10O7","InChI=1S/C43H44N10O7/c1-5-52-32(20-28(50-52)23-13-14-23)46-38-36-26-19-31(59-4)27(34-21(2)51-60-22(34)3)18-29(26)45-37(36)48-39(49-38)41(56)44-17-8-6-7-10-24-11-9-12-25-35(24)43(58)53(42(25)57)30-15-16-33(54)47-40(30)55/h9,11-12,18-20,23,30H,5-8,10,13-17H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","USXQCAQGOVVSTI-UHFFFAOYSA-N"
"139","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.14/2.1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.888","812.339443748","5.27","60","9","13","4","14","219.33","C43H44N10O7","InChI=1S/C43H44N10O7/c1-5-52-32(20-28(50-52)23-13-14-23)46-38-36-26-19-31(59-4)27(34-21(2)51-60-22(34)3)18-29(26)45-37(36)48-39(49-38)41(56)44-17-8-6-7-10-24-11-9-12-25-35(24)43(58)53(42(25)57)30-15-16-33(54)47-40(30)55/h9,11-12,18-20,23,30H,5-8,10,13-17H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","USXQCAQGOVVSTI-UHFFFAOYSA-N"
"140","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.037/1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.932","812.375829256","5.86","60","9","12","4","15","202.26","C44H48N10O6","InChI=1S/C44H48N10O6/c1-5-54-35(21-31(51-54)26-14-15-26)47-40-38-28-20-34(59-4)29(37-23(2)52-60-24(37)3)19-32(28)46-39(38)49-41(50-40)43(57)45-18-9-7-6-8-11-25-12-10-13-27-30(25)22-53(44(27)58)33-16-17-36(55)48-42(33)56/h10,12-13,19-21,26,33H,5-9,11,14-18,22H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","ZPFSVCFXZLONQL-UHFFFAOYSA-N"
"140","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.037/1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.932","812.375829256","5.86","60","9","12","4","15","202.26","C44H48N10O6","InChI=1S/C44H48N10O6/c1-5-54-35(21-31(51-54)26-14-15-26)47-40-38-28-20-34(59-4)29(37-23(2)52-60-24(37)3)19-32(28)46-39(38)49-41(50-40)43(57)45-18-9-7-6-8-11-25-12-10-13-27-30(25)22-53(44(27)58)33-16-17-36(55)48-42(33)56/h10,12-13,19-21,26,33H,5-9,11,14-18,22H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","ZPFSVCFXZLONQL-UHFFFAOYSA-N"
"140","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.037/1","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","812.932","812.375829256","5.86","60","9","12","4","15","202.26","C44H48N10O6","InChI=1S/C44H48N10O6/c1-5-54-35(21-31(51-54)26-14-15-26)47-40-38-28-20-34(59-4)29(37-23(2)52-60-24(37)3)19-32(28)46-39(38)49-41(50-40)43(57)45-18-9-7-6-8-11-25-12-10-13-27-30(25)22-53(44(27)58)33-16-17-36(55)48-42(33)56/h10,12-13,19-21,26,33H,5-9,11,14-18,22H2,1-4H3,(H,45,57)(H,48,55,56)(H2,46,47,49,50)","ZPFSVCFXZLONQL-UHFFFAOYSA-N"
"141","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCOCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9/5.4","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","814.904","814.355093812","4.28","60","9","13","4","15","211.49","C43H46N10O7","InChI=1S/C43H46N10O7/c1-5-53-34(20-30(50-53)25-11-12-25)46-39-37-27-19-33(58-4)28(36-22(2)51-60-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-15-17-59-16-7-9-24-8-6-10-26-29(24)21-52(43(26)57)32-13-14-35(54)47-41(32)55/h6,8,10,18-20,25,32H,5,7,9,11-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","KBEYNZWEDMUCOU-UHFFFAOYSA-N"
"141","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCOCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9/5.4","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","814.904","814.355093812","4.28","60","9","13","4","15","211.49","C43H46N10O7","InChI=1S/C43H46N10O7/c1-5-53-34(20-30(50-53)25-11-12-25)46-39-37-27-19-33(58-4)28(36-22(2)51-60-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-15-17-59-16-7-9-24-8-6-10-26-29(24)21-52(43(26)57)32-13-14-35(54)47-41(32)55/h6,8,10,18-20,25,32H,5,7,9,11-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","KBEYNZWEDMUCOU-UHFFFAOYSA-N"
"141","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCOCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9/5.4","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","814.904","814.355093812","4.28","60","9","13","4","15","211.49","C43H46N10O7","InChI=1S/C43H46N10O7/c1-5-53-34(20-30(50-53)25-11-12-25)46-39-37-27-19-33(58-4)28(36-22(2)51-60-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-15-17-59-16-7-9-24-8-6-10-26-29(24)21-52(43(26)57)32-13-14-35(54)47-41(32)55/h6,8,10,18-20,25,32H,5,7,9,11-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","KBEYNZWEDMUCOU-UHFFFAOYSA-N"
"142","P25440","BRD2","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.051/2.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","Q15059","BRD3","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.051/2.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","O60885","BRD4","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.051/2.2","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","P25440","BRD2","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.36/2.2/0.051","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","Q15059","BRD3","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.36/2.2/0.051","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","O60885","BRD4","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.36/2.2/0.051","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","P25440","BRD2","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5146/0.881","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","Q15059","BRD3","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5146/0.881","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"142","O60885","BRD4","CRBN","","BETd-260","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5146/0.881","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","798.905","798.360179192","5.32","59","9","12","4","14","202.26","C43H46N10O6","InChI=1S/C43H46N10O6/c1-5-53-34(20-30(50-53)25-13-14-25)46-39-37-27-19-33(58-4)28(36-22(2)51-59-23(36)3)18-31(27)45-38(37)48-40(49-39)42(56)44-17-8-6-7-10-24-11-9-12-26-29(24)21-52(43(26)57)32-15-16-35(54)47-41(32)55/h9,11-12,18-20,25,32H,5-8,10,13-17,21H2,1-4H3,(H,44,56)(H,47,54,55)(H2,45,46,48,49)","UZXANFBIRSYHGO-UHFFFAOYSA-N"
"143","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.98/13.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","784.878","784.344529128","4.78","58","9","12","4","13","202.26","C42H44N10O6","InChI=1S/C42H44N10O6/c1-5-52-33(19-29(49-52)24-12-13-24)45-38-36-26-18-32(57-4)27(35-21(2)50-58-22(35)3)17-30(26)44-37(36)47-39(48-38)41(55)43-16-7-6-9-23-10-8-11-25-28(23)20-51(42(25)56)31-14-15-34(53)46-40(31)54/h8,10-11,17-19,24,31H,5-7,9,12-16,20H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","CARBHFWOADFVCJ-UHFFFAOYSA-N"
"143","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.98/13.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","784.878","784.344529128","4.78","58","9","12","4","13","202.26","C42H44N10O6","InChI=1S/C42H44N10O6/c1-5-52-33(19-29(49-52)24-12-13-24)45-38-36-26-18-32(57-4)27(35-21(2)50-58-22(35)3)17-30(26)44-37(36)47-39(48-38)41(55)43-16-7-6-9-23-10-8-11-25-28(23)20-51(42(25)56)31-14-15-34(53)46-40(31)54/h8,10-11,17-19,24,31H,5-7,9,12-16,20H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","CARBHFWOADFVCJ-UHFFFAOYSA-N"
"143","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.98/13.7","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","784.878","784.344529128","4.78","58","9","12","4","13","202.26","C42H44N10O6","InChI=1S/C42H44N10O6/c1-5-52-33(19-29(49-52)24-12-13-24)45-38-36-26-18-32(57-4)27(35-21(2)50-58-22(35)3)17-30(26)44-37(36)47-39(48-38)41(55)43-16-7-6-9-23-10-8-11-25-28(23)20-51(42(25)56)31-14-15-34(53)46-40(31)54/h8,10-11,17-19,24,31H,5-7,9,12-16,20H2,1-4H3,(H,43,55)(H,46,53,54)(H2,44,45,47,48)","CARBHFWOADFVCJ-UHFFFAOYSA-N"
"144","P25440","BRD2","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.6/72.3","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","770.851","770.328879064","4.42","57","9","12","4","12","202.26","C41H42N10O6","InChI=1S/C41H42N10O6/c1-5-51-32(18-28(48-51)23-11-12-23)44-37-35-25-17-31(56-4)26(34-20(2)49-57-21(34)3)16-29(25)43-36(35)46-38(47-37)40(54)42-15-7-9-22-8-6-10-24-27(22)19-50(41(24)55)30-13-14-33(52)45-39(30)53/h6,8,10,16-18,23,30H,5,7,9,11-15,19H2,1-4H3,(H,42,54)(H,45,52,53)(H2,43,44,46,47)","LKCUEUQTTCOYPW-UHFFFAOYSA-N"
"144","Q15059","BRD3","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.6/72.3","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","770.851","770.328879064","4.42","57","9","12","4","12","202.26","C41H42N10O6","InChI=1S/C41H42N10O6/c1-5-51-32(18-28(48-51)23-11-12-23)44-37-35-25-17-31(56-4)26(34-20(2)49-57-21(34)3)16-29(25)43-36(35)46-38(47-37)40(54)42-15-7-9-22-8-6-10-24-27(22)19-50(41(24)55)30-13-14-33(52)45-39(30)53/h6,8,10,16-18,23,30H,5,7,9,11-15,19H2,1-4H3,(H,42,54)(H,45,52,53)(H2,43,44,46,47)","LKCUEUQTTCOYPW-UHFFFAOYSA-N"
"144","O60885","BRD4","CRBN","","","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.6/72.3","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","770.851","770.328879064","4.42","57","9","12","4","12","202.26","C41H42N10O6","InChI=1S/C41H42N10O6/c1-5-51-32(18-28(48-51)23-11-12-23)44-37-35-25-17-31(56-4)26(34-20(2)49-57-21(34)3)16-29(25)43-36(35)46-38(47-37)40(54)42-15-7-9-22-8-6-10-24-27(22)19-50(41(24)55)30-13-14-33(52)45-39(30)53/h6,8,10,16-18,23,30H,5,7,9,11-15,19H2,1-4H3,(H,42,54)(H,45,52,53)(H2,43,44,46,47)","LKCUEUQTTCOYPW-UHFFFAOYSA-N"
"145","P25440","BRD2","CRBN","","","COC1=CC2=C(C=C1C1=C(C)ON=C1C)[NH]C1=NC(C(=O)NCCCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","649.708","649.26488184","3.93","48","7","9","3","10","172.41","C35H35N7O6","InChI=1S/C35H35N7O6/c1-18-30(19(2)48-41-18)23-14-26-22(15-28(23)47-3)24-16-37-32(40-31(24)38-26)34(45)36-13-6-4-5-8-20-9-7-10-21-25(20)17-42(35(21)46)27-11-12-29(43)39-33(27)44/h7,9-10,14-16,27H,4-6,8,11-13,17H2,1-3H3,(H,36,45)(H,37,38,40)(H,39,43,44)","QDTUZWSUASQJJP-UHFFFAOYSA-N"
"145","Q15059","BRD3","CRBN","","","COC1=CC2=C(C=C1C1=C(C)ON=C1C)[NH]C1=NC(C(=O)NCCCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","649.708","649.26488184","3.93","48","7","9","3","10","172.41","C35H35N7O6","InChI=1S/C35H35N7O6/c1-18-30(19(2)48-41-18)23-14-26-22(15-28(23)47-3)24-16-37-32(40-31(24)38-26)34(45)36-13-6-4-5-8-20-9-7-10-21-25(20)17-42(35(21)46)27-11-12-29(43)39-33(27)44/h7,9-10,14-16,27H,4-6,8,11-13,17H2,1-3H3,(H,36,45)(H,37,38,40)(H,39,43,44)","QDTUZWSUASQJJP-UHFFFAOYSA-N"
"145","O60885","BRD4","CRBN","","","COC1=CC2=C(C=C1C1=C(C)ON=C1C)[NH]C1=NC(C(=O)NCCCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","649.708","649.26488184","3.93","48","7","9","3","10","172.41","C35H35N7O6","InChI=1S/C35H35N7O6/c1-18-30(19(2)48-41-18)23-14-26-22(15-28(23)47-3)24-16-37-32(40-31(24)38-26)34(45)36-13-6-4-5-8-20-9-7-10-21-25(20)17-42(35(21)46)27-11-12-29(43)39-33(27)44/h7,9-10,14-16,27H,4-6,8,11-13,17H2,1-3H3,(H,36,45)(H,37,38,40)(H,39,43,44)","QDTUZWSUASQJJP-UHFFFAOYSA-N"
"146","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCN1C=C(COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","490/500","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","781.255","780.199377456","2.39","55","8","14","2","10","195.66","C37H33ClN10O6S","InChI=1S/C37H33ClN10O6S/c1-18-19(2)55-37-30(18)32(21-7-9-22(38)10-8-21)40-25(33-44-42-20(3)47(33)37)15-29(50)39-13-14-46-16-23(43-45-46)17-54-27-6-4-5-24-31(27)36(53)48(35(24)52)26-11-12-28(49)41-34(26)51/h4-10,16,25-26H,11-15,17H2,1-3H3,(H,39,50)(H,41,49,51)/t25-,26?/m0/s1","CBYYXVFBNBBZJH-PMCHYTPCSA-N"
"147","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCN1C=C(COCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1",">5000/130","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","825.308","824.225592204","2.25","58","8","15","2","13","204.89","C39H37ClN10O7S","InChI=1S/C39H37ClN10O7S/c1-20-21(2)58-39-32(20)34(23-7-9-24(40)10-8-23)42-27(35-46-44-22(3)49(35)39)17-31(52)41-13-14-48-18-25(45-47-48)19-56-15-16-57-29-6-4-5-26-33(29)38(55)50(37(26)54)28-11-12-30(51)43-36(28)53/h4-10,18,27-28H,11-17,19H2,1-3H3,(H,41,52)(H,43,51,53)/t27-,28?/m0/s1","ABDSEHSFEXENQJ-MBMZGMDYSA-N"
"148","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCN1C=C(COCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1",">5000/1260","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","869.361","868.251806952","2.1","61","8","16","2","16","214.12","C41H41ClN10O8S","InChI=1S/C41H41ClN10O8S/c1-22-23(2)61-41-34(22)36(25-7-9-26(42)10-8-25)44-29(37-48-46-24(3)51(37)41)19-33(54)43-13-14-50-20-27(47-49-50)21-59-16-15-58-17-18-60-31-6-4-5-28-35(31)40(57)52(39(28)56)30-11-12-32(53)45-38(30)55/h4-10,20,29-30H,11-19,21H2,1-3H3,(H,43,54)(H,45,53,55)/t29-,30?/m0/s1","QDKBKEFTDKCTPJ-UFXYQILXSA-N"
"149","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCN1C=C(COCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","450/250","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","913.414","912.2780217","1.95","64","8","17","2","19","223.35","C43H45ClN10O9S","InChI=1S/C43H45ClN10O9S/c1-24-25(2)64-43-36(24)38(27-7-9-28(44)10-8-27)46-31(39-50-48-26(3)53(39)43)21-35(56)45-13-14-52-22-29(49-51-52)23-62-18-17-60-15-16-61-19-20-63-33-6-4-5-30-37(33)42(59)54(41(30)58)32-11-12-34(55)47-40(32)57/h4-10,22,31-32H,11-21,23H2,1-3H3,(H,45,56)(H,47,55,57)/t31-,32?/m0/s1","SVZFVYLDQTZFKW-CYZZXXEPSA-N"
"150","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCN1C=C(COCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","200/150","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","957.467","956.304236448","1.8","67","8","18","2","22","232.58","C45H49ClN10O10S","InChI=1S/C45H49ClN10O10S/c1-26-27(2)67-45-38(26)40(29-7-9-30(46)10-8-29)48-33(41-52-50-28(3)55(41)45)23-37(58)47-13-14-54-24-31(51-53-54)25-65-20-19-63-16-15-62-17-18-64-21-22-66-35-6-4-5-32-39(35)44(61)56(43(32)60)34-11-12-36(57)49-42(34)59/h4-10,24,33-34H,11-23,25H2,1-3H3,(H,47,58)(H,49,57,59)/t33-,34?/m0/s1","NQCJKUWEAOYMRX-CDRRMRQFSA-N"
"151","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC3=CN(CCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)N=N3)C(C)(C)C)C=C2)SC=N1","59/550","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","995.633","994.34974716","4.49","69","8","16","4","16","223.74","C48H55ClN12O6S2","InChI=1S/C48H55ClN12O6S2/c1-26-28(3)69-47-40(26)41(31-12-14-33(49)15-13-31)53-36(44-57-55-29(4)61(44)47)19-38(63)50-16-17-59-21-34(56-58-59)23-67-24-39(64)54-43(48(5,6)7)46(66)60-22-35(62)18-37(60)45(65)51-20-30-8-10-32(11-9-30)42-27(2)52-25-68-42/h8-15,21,25,35-37,43,62H,16-20,22-24H2,1-7H3,(H,50,63)(H,51,65)(H,54,64)/t35-,36+,37+,43-/m1/s1","KEXVSUAHVFYWJC-AYWQWSHZSA-N"
"152","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCC3=CN(CCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)N=N3)C(C)(C)C)C=C2)SC=N1","83/470","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","1039.686","1038.37596191","4.34","72","8","17","4","19","232.97","C50H59ClN12O7S2","InChI=1S/C50H59ClN12O7S2/c1-28-30(3)72-49-42(28)43(33-12-14-35(51)15-13-33)55-38(46-59-57-31(4)63(46)49)21-40(65)52-16-17-61-23-36(58-60-61)25-69-18-19-70-26-41(66)56-45(50(5,6)7)48(68)62-24-37(64)20-39(62)47(67)53-22-32-8-10-34(11-9-32)44-29(2)54-27-71-44/h8-15,23,27,37-39,45,64H,16-22,24-26H2,1-7H3,(H,52,65)(H,53,67)(H,56,66)/t37-,38+,39+,45-/m1/s1","LJQXZKRBYGZAEU-DPSJZEHMSA-N"
"153","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC3=CN(CCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)N=N3)C(C)(C)C)C=C2)SC=N1","240/1670","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","1083.739","1082.40217666","4.19","75","8","18","4","22","242.2","C52H63ClN12O8S2","InChI=1S/C52H63ClN12O8S2/c1-30-32(3)75-51-44(30)45(35-12-14-37(53)15-13-35)57-40(48-61-59-33(4)65(48)51)23-42(67)54-16-17-63-25-38(60-62-63)27-72-20-18-71-19-21-73-28-43(68)58-47(52(5,6)7)50(70)64-26-39(66)22-41(64)49(69)55-24-34-8-10-36(11-9-34)46-31(2)56-29-74-46/h8-15,25,29,39-41,47,66H,16-24,26-28H2,1-7H3,(H,54,67)(H,55,69)(H,58,68)/t39-,40+,41+,47-/m1/s1","IVAWBGJHAWQINS-XRFVFAKVSA-N"
"154","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC3=CN(CCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)N=N3)C(C)(C)C)C=C2)SC=N1","460/3660","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","1127.792","1126.4283914","4.05","78","8","19","4","25","251.43","C54H67ClN12O9S2","InChI=1S/C54H67ClN12O9S2/c1-32-34(3)78-53-46(32)47(37-12-14-39(55)15-13-37)59-42(50-63-61-35(4)67(50)53)25-44(69)56-16-17-65-27-40(62-64-65)29-75-22-20-73-18-19-74-21-23-76-30-45(70)60-49(54(5,6)7)52(72)66-28-41(68)24-43(66)51(71)57-26-36-8-10-38(11-9-36)48-33(2)58-31-77-48/h8-15,27,31,41-43,49,68H,16-26,28-30H2,1-7H3,(H,56,69)(H,57,71)(H,60,70)/t41-,42+,43+,49-/m1/s1","MEUHHKBLLJDOBF-ADSXHIEZSA-N"
"155","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC3=CN(CCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)N=N3)C(C)(C)C)C=C2)SC=N1","630/2730","","Degradation of BRD4 in NCI-H661/NCI-H838 cells after 4h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01781","1171.845","1170.45460615","3.9","81","8","20","4","28","260.66","C56H71ClN12O10S2","InChI=1S/C56H71ClN12O10S2/c1-34-36(3)81-55-48(34)49(39-12-14-41(57)15-13-39)61-44(52-65-63-37(4)69(52)55)27-46(71)58-16-17-67-29-42(64-66-67)31-78-24-22-76-20-18-75-19-21-77-23-25-79-32-47(72)62-51(56(5,6)7)54(74)68-30-43(70)26-45(68)53(73)59-28-38-8-10-40(11-9-38)50-35(2)60-33-80-50/h8-15,29,33,43-45,51,70H,16-28,30-32H2,1-7H3,(H,58,71)(H,59,73)(H,62,72)/t43-,44+,45+,51-/m1/s1","VACBBPVTGHKINF-WQZGMAASSA-N"
"156","Q8IXJ6","SIRT2","CRBN","","","CC1=CC(C)=NC(SCC(=O)NC2=NC=C(CC3=CC=CC(OCC4=CN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)=C3)S2)=N1","","","","","","250","Inhibition of SIRT2 in a fluorescence-based deacetylase activity assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01872","852.956","852.24720024","3.2","60","7","16","3","18","229.59","C40H40N10O8S2","InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)","GRYRXFYWVDWPQY-UHFFFAOYSA-N"
"157","P25440","BRD2","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000/>1000","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","643.685","643.1637879","2.91","47","8","11","1","4","141.31","C34H25N7O5S","InChI=1S/C34H25N7O5S/c1-19-37-38-28-18-46-17-24-23(14-20-6-3-2-4-7-20)27(47-34(24)40(19)28)12-10-21-15-35-39(16-21)25-9-5-8-22-30(25)33(45)41(32(22)44)26-11-13-29(42)36-31(26)43/h2-9,15-16,26H,11,13-14,17-18H2,1H3,(H,36,42,43)","XMGPEMLEGUYJRH-UHFFFAOYSA-N"
"157","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000/>1000","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","643.685","643.1637879","2.91","47","8","11","1","4","141.31","C34H25N7O5S","InChI=1S/C34H25N7O5S/c1-19-37-38-28-18-46-17-24-23(14-20-6-3-2-4-7-20)27(47-34(24)40(19)28)12-10-21-15-35-39(16-21)25-9-5-8-22-30(25)33(45)41(32(22)44)26-11-13-29(42)36-31(26)43/h2-9,15-16,26H,11,13-14,17-18H2,1H3,(H,36,42,43)","XMGPEMLEGUYJRH-UHFFFAOYSA-N"
"157","O60885","BRD4","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000/>1000","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","643.685","643.1637879","2.91","47","8","11","1","4","141.31","C34H25N7O5S","InChI=1S/C34H25N7O5S/c1-19-37-38-28-18-46-17-24-23(14-20-6-3-2-4-7-20)27(47-34(24)40(19)28)12-10-21-15-35-39(16-21)25-9-5-8-22-30(25)33(45)41(32(22)44)26-11-13-29(42)36-31(26)43/h2-9,15-16,26H,11,13-14,17-18H2,1H3,(H,36,42,43)","XMGPEMLEGUYJRH-UHFFFAOYSA-N"
"158","P25440","BRD2","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20.81/19.7/311","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","673.711","673.174352584","2.95","49","8","12","1","6","150.54","C35H27N7O6S","InChI=1S/C35H27N7O6S/c1-20-38-39-29-18-47-17-25-24(14-21-6-3-2-4-7-21)28(49-35(25)41(20)29)12-10-22-15-36-40(16-22)19-48-27-9-5-8-23-31(27)34(46)42(33(23)45)26-11-13-30(43)37-32(26)44/h2-9,15-16,26H,11,13-14,17-19H2,1H3,(H,37,43,44)","QHVZSCKJXMNSAT-UHFFFAOYSA-N"
"158","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20.81/19.7/311","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","673.711","673.174352584","2.95","49","8","12","1","6","150.54","C35H27N7O6S","InChI=1S/C35H27N7O6S/c1-20-38-39-29-18-47-17-25-24(14-21-6-3-2-4-7-21)28(49-35(25)41(20)29)12-10-22-15-36-40(16-22)19-48-27-9-5-8-23-31(27)34(46)42(33(23)45)26-11-13-30(43)37-32(26)44/h2-9,15-16,26H,11,13-14,17-19H2,1H3,(H,37,43,44)","QHVZSCKJXMNSAT-UHFFFAOYSA-N"
"158","O60885","BRD4","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20.81/19.7/311","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","673.711","673.174352584","2.95","49","8","12","1","6","150.54","C35H27N7O6S","InChI=1S/C35H27N7O6S/c1-20-38-39-29-18-47-17-25-24(14-21-6-3-2-4-7-21)28(49-35(25)41(20)29)12-10-22-15-36-40(16-22)19-48-27-9-5-8-23-31(27)34(46)42(33(23)45)26-11-13-30(43)37-32(26)44/h2-9,15-16,26H,11,13-14,17-19H2,1H3,(H,37,43,44)","QHVZSCKJXMNSAT-UHFFFAOYSA-N"
"159","P25440","BRD2","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.379/0.47/2.23","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","686.754","686.20598706","3.41","50","8","12","2","7","153.34","C36H30N8O5S","InChI=1S/C36H30N8O5S/c1-21-40-41-30-20-49-19-26-25(16-22-6-3-2-4-7-22)29(50-36(26)43(21)30)12-10-23-17-38-42(18-23)15-14-37-27-9-5-8-24-32(27)35(48)44(34(24)47)28-11-13-31(45)39-33(28)46/h2-9,17-18,28,37H,11,13-16,19-20H2,1H3,(H,39,45,46)","OCRZEXONTRGXJJ-UHFFFAOYSA-N"
"159","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.379/0.47/2.23","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","686.754","686.20598706","3.41","50","8","12","2","7","153.34","C36H30N8O5S","InChI=1S/C36H30N8O5S/c1-21-40-41-30-20-49-19-26-25(16-22-6-3-2-4-7-22)29(50-36(26)43(21)30)12-10-23-17-38-42(18-23)15-14-37-27-9-5-8-24-32(27)35(48)44(34(24)47)28-11-13-31(45)39-33(28)46/h2-9,17-18,28,37H,11,13-16,19-20H2,1H3,(H,39,45,46)","OCRZEXONTRGXJJ-UHFFFAOYSA-N"
"159","O60885","BRD4","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.379/0.47/2.23","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","686.754","686.20598706","3.41","50","8","12","2","7","153.34","C36H30N8O5S","InChI=1S/C36H30N8O5S/c1-21-40-41-30-20-49-19-26-25(16-22-6-3-2-4-7-22)29(50-36(26)43(21)30)12-10-23-17-38-42(18-23)15-14-37-27-9-5-8-24-32(27)35(48)44(34(24)47)28-11-13-31(45)39-33(28)46/h2-9,17-18,28,37H,11,13-16,19-20H2,1H3,(H,39,45,46)","OCRZEXONTRGXJJ-UHFFFAOYSA-N"
"160","P25440","BRD2","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.038/0.138/0.56","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","700.781","700.221637124","3.77","51","8","12","2","8","153.34","C37H32N8O5S","InChI=1S/C37H32N8O5S/c1-22-41-42-31-21-50-20-27-26(17-23-7-3-2-4-8-23)30(51-37(27)44(22)31)13-11-24-18-39-43(19-24)16-6-15-38-28-10-5-9-25-33(28)36(49)45(35(25)48)29-12-14-32(46)40-34(29)47/h2-5,7-10,18-19,29,38H,6,12,14-17,20-21H2,1H3,(H,40,46,47)","SYQRBMOCQVOCGE-UHFFFAOYSA-N"
"160","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.038/0.138/0.56","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","700.781","700.221637124","3.77","51","8","12","2","8","153.34","C37H32N8O5S","InChI=1S/C37H32N8O5S/c1-22-41-42-31-21-50-20-27-26(17-23-7-3-2-4-8-23)30(51-37(27)44(22)31)13-11-24-18-39-43(19-24)16-6-15-38-28-10-5-9-25-33(28)36(49)45(35(25)48)29-12-14-32(46)40-34(29)47/h2-5,7-10,18-19,29,38H,6,12,14-17,20-21H2,1H3,(H,40,46,47)","SYQRBMOCQVOCGE-UHFFFAOYSA-N"
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"165","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.081/0.14/0.53","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","699.837","699.262773664","4.45","51","8","10","1","9","124.24","C39H37N7O4S","InChI=1S/C39H37N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,6-7,11,15,17-19,22-24H2,1H3,(H,41,47,48)","BQDOHNREIRUBJS-UHFFFAOYSA-N"
"165","O60885","BRD4","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.081/0.14/0.53","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","699.837","699.262773664","4.45","51","8","10","1","9","124.24","C39H37N7O4S","InChI=1S/C39H37N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,6-7,11,15,17-19,22-24H2,1H3,(H,41,47,48)","BQDOHNREIRUBJS-UHFFFAOYSA-N"
"166","P25440","BRD2","CRBN","","QCA570","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.032/0.0083/0.062","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","695.805","695.231473536","3.95","51","8","10","1","6","124.24","C39H33N7O4S","InChI=1S/C39H33N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,7,15,17-19,22-24H2,1H3,(H,41,47,48)","RTVTYLRQKKDYMQ-UHFFFAOYSA-N"
"166","Q15059","BRD3","CRBN","","QCA570","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.032/0.0083/0.062","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","695.805","695.231473536","3.95","51","8","10","1","6","124.24","C39H33N7O4S","InChI=1S/C39H33N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,7,15,17-19,22-24H2,1H3,(H,41,47,48)","RTVTYLRQKKDYMQ-UHFFFAOYSA-N"
"166","O60885","BRD4","CRBN","","QCA570","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.032/0.0083/0.062","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","695.805","695.231473536","3.95","51","8","10","1","6","124.24","C39H33N7O4S","InChI=1S/C39H33N7O4S/c1-25-42-43-35-24-50-23-32-30(19-26-9-4-2-5-10-26)34(51-39(32)46(25)35)16-14-27-20-40-44(21-27)18-7-3-6-11-28-12-8-13-29-31(28)22-45(38(29)49)33-15-17-36(47)41-37(33)48/h2,4-5,8-10,12-13,20-21,33H,3,7,15,17-19,22-24H2,1H3,(H,41,47,48)","RTVTYLRQKKDYMQ-UHFFFAOYSA-N"
"167","P25440","BRD2","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.39/0.72/1.6","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","709.788","709.210738092","3.89","52","8","11","1","6","141.31","C39H31N7O5S","InChI=1S/C39H31N7O5S/c1-24-42-43-33-23-51-22-30-29(19-25-9-4-2-5-10-25)32(52-39(30)45(24)33)16-14-26-20-40-44(21-26)18-7-3-6-11-27-12-8-13-28-35(27)38(50)46(37(28)49)31-15-17-34(47)41-36(31)48/h2,4-5,8-10,12-13,20-21,31H,3,7,15,17-19,22-23H2,1H3,(H,41,47,48)","QPMJTSIHTLZBDG-UHFFFAOYSA-N"
"167","Q15059","BRD3","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.39/0.72/1.6","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","709.788","709.210738092","3.89","52","8","11","1","6","141.31","C39H31N7O5S","InChI=1S/C39H31N7O5S/c1-24-42-43-33-23-51-22-30-29(19-25-9-4-2-5-10-25)32(52-39(30)45(24)33)16-14-26-20-40-44(21-26)18-7-3-6-11-27-12-8-13-28-35(27)38(50)46(37(28)49)31-15-17-34(47)41-36(31)48/h2,4-5,8-10,12-13,20-21,31H,3,7,15,17-19,22-23H2,1H3,(H,41,47,48)","QPMJTSIHTLZBDG-UHFFFAOYSA-N"
"167","O60885","BRD4","CRBN","","","CC1=NN=C2COCC3=C(SC(C#CC4=CN(CCCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=C4)=C3CC3=CC=CC=C3)N12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.39/0.72/1.6","Inhibit growth of RS4;11/MV4;11/MOLM13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","709.788","709.210738092","3.89","52","8","11","1","6","141.31","C39H31N7O5S","InChI=1S/C39H31N7O5S/c1-24-42-43-33-23-51-22-30-29(19-25-9-4-2-5-10-25)32(52-39(30)45(24)33)16-14-26-20-40-44(21-26)18-7-3-6-11-27-12-8-13-28-35(27)38(50)46(37(28)49)31-15-17-34(47)41-36(31)48/h2,4-5,8-10,12-13,20-21,31H,3,7,15,17-19,22-23H2,1H3,(H,41,47,48)","QPMJTSIHTLZBDG-UHFFFAOYSA-N"
"168","P09874","PARP1","CRBN","","","NC(=O)C1=CC=CC2=CN(C3=CC=C(C4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc07813k","779.811","779.302723892","1.31","57","7","15","3","20","224.12","C39H41N9O9","InChI=1S/C39H41N9O9/c40-36(50)29-5-1-3-26-23-47(44-35(26)29)27-9-7-25(8-10-27)31-24-46(45-43-31)14-16-55-18-20-57-22-21-56-19-17-54-15-13-41-30-6-2-4-28-34(30)39(53)48(38(28)52)32-11-12-33(49)42-37(32)51/h1-10,23-24,32,41H,11-22H2,(H2,40,50)(H,42,49,51)","INQDATHUJVPRBB-UHFFFAOYSA-N"
"169","P09874","PARP1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@H]3C[C@H](O)CN3C(=O)C(NC(=O)CCC(=O)NCCOCCOCCOCCN3C=C(C4=CC=C(N5C=C6C=CC=C(C(N)=O)C6=N5)C=C4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc07813k","992.173","991.437443532","2.29","71","7","16","5","24","260.04","C50H61N11O9S","InChI=1S/C50H61N11O9S/c1-32-45(71-31-54-32)35-10-8-33(9-11-35)27-53-48(66)41-26-38(62)29-60(41)49(67)46(50(2,3)4)55-43(64)17-16-42(63)52-18-20-68-22-24-70-25-23-69-21-19-59-30-40(56-58-59)34-12-14-37(15-13-34)61-28-36-6-5-7-39(47(51)65)44(36)57-61/h5-15,28,30-31,38,41,46,62H,16-27,29H2,1-4H3,(H2,51,65)(H,52,63)(H,53,66)(H,55,64)/t38-,41+,46?/m0/s1","RNMJBKIZLSDYTG-ADBSINBISA-N"
"170","P09874","PARP1","MDM2","","","COC1=CC=C(C2=NC(C3=CC=C(Cl)C=C3)C(C3=CC=C(Cl)C=C3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCCOCCN3C=C(C4=CC=C(N5C=C6C=CC=C(C(N)=O)C6=N5)C=C4)N=N3)C(=O)C2)C(OC(C)C)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6550","Inhibit proliferation of MDA-MB-231 cells","","","","","","","","","","","","","","","10.1039/c8cc07813k","1145.115","1143.41364258","5.38","81","9","16","2","26","232.32","C58H63Cl2N11O10","InChI=1S/C58H63Cl2N11O10/c1-38(2)81-50-33-46(76-3)19-20-47(50)57-63-54(40-7-13-43(59)14-8-40)55(41-9-15-44(60)16-10-41)71(57)58(75)68-23-22-67(52(73)37-68)36-51(72)62-21-25-77-27-29-79-31-32-80-30-28-78-26-24-69-35-49(64-66-69)39-11-17-45(18-12-39)70-34-42-5-4-6-48(56(61)74)53(42)65-70/h4-20,33-35,38,54-55H,21-32,36-37H2,1-3H3,(H2,61,74)(H,62,72)","RQWKTYKJNCZUJW-UHFFFAOYSA-N"
"171","P09874","PARP1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCN4C=C(CCCC(=O)N5CCN(C(=O)C6=CC(CC7=N[NH]C(=O)C8=CC=CC=C78)=CC=C6F)CC5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc07813k","979.036","978.4035808","1.27","71","8","16","3","24","249.58","C49H55FN10O11","InChI=1S/C49H55FN10O11/c50-38-12-11-32(30-40-34-6-1-2-7-35(34)45(63)55-54-40)29-37(38)47(65)58-18-16-57(17-19-58)43(62)10-3-5-33-31-59(56-53-33)20-22-69-24-26-71-28-27-70-25-23-68-21-15-51-39-9-4-8-36-44(39)49(67)60(48(36)66)41-13-14-42(61)52-46(41)64/h1-2,4,6-9,11-12,29,31,41,51H,3,5,10,13-28,30H2,(H,55,63)(H,52,61,64)","KQVOZXPLIICOGI-UHFFFAOYSA-N"
"172","P09874","PARP1","MDM2","","","COC1=CC=C(C2=NC(C3=CC=C(Cl)C=C3)C(C3=CC=C(Cl)C=C3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCCOCCN3C=C(CCCC(=O)N4CCN(C(=O)C5=CC(CC6=N[NH]C(=O)C7=CC=CC=C67)=CC=C5F)CC4)N=N3)C(=O)C2)C(OC(C)C)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc07813k","1344.34","1342.51449948","5.34","95","10","17","2","30","257.78","C68H77Cl2FN12O12","InChI=1S/C68H77Cl2FN12O12/c1-45(2)95-59-41-52(90-3)20-21-55(59)65-73-63(47-12-16-49(69)17-13-47)64(48-14-18-50(70)19-15-48)83(65)68(89)81-29-28-80(62(86)44-81)43-60(84)72-23-31-91-33-35-93-37-38-94-36-34-92-32-30-82-42-51(74-77-82)7-6-10-61(85)78-24-26-79(27-25-78)67(88)56-39-46(11-22-57(56)71)40-58-53-8-4-5-9-54(53)66(87)76-75-58/h4-5,8-9,11-22,39,41-42,45,63-64H,6-7,10,23-38,40,43-44H2,1-3H3,(H,72,84)(H,76,87)","NNPBIHACMXHNOK-UHFFFAOYSA-N"
"173","Q96SW2","CRBN","VHL","","CRBN-2-2-2-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","831.949","831.326161768","2.48","59","6","13","5","16","225.67","C41H49N7O10S","InChI=1S/C41H49N7O10S/c1-23-34(59-22-44-23)25-10-8-24(9-11-25)19-43-36(52)30-18-26(49)20-47(30)40(56)35(41(2,3)4)45-32(51)21-58-17-16-57-15-14-42-28-7-5-6-27-33(28)39(55)48(38(27)54)29-12-13-31(50)46-37(29)53/h5-11,22,26,29-30,35,42,49H,12-21H2,1-4H3,(H,43,52)(H,45,51)(H,46,50,53)/t26-,29?,30+,35-/m1/s1","YPKQEFMVVKVSQU-RXJDTIOWSA-N"
"174","Q96SW2","CRBN","VHL","","TD-343","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","367.8","85.1","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","876.002","875.352376516","2.33","62","6","14","5","19","234.9","C43H53N7O11S","InChI=1S/C43H53N7O11S/c1-25-36(62-24-46-25)27-10-8-26(9-11-27)21-45-38(54)32-20-28(51)22-49(32)42(58)37(43(2,3)4)47-34(53)23-61-19-18-60-17-16-59-15-14-44-30-7-5-6-29-35(30)41(57)50(40(29)56)31-12-13-33(52)48-39(31)55/h5-11,24,28,31-32,37,44,51H,12-23H2,1-4H3,(H,45,54)(H,47,53)(H,48,52,55)/t28-,31?,32+,37-/m1/s1","JJODRHXPKVBYEY-JPQBYMPPSA-N"
"175","Q96SW2","CRBN","VHL","","CRBN-2-2-2-5-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","918.083","917.399326708","2.95","65","6","14","5","22","234.9","C46H59N7O11S","InChI=1S/C46H59N7O11S/c1-28-39(65-27-49-28)30-13-11-29(12-14-30)25-48-41(57)35-24-31(54)26-52(35)45(61)40(46(2,3)4)50-36(55)10-5-6-18-62-20-22-64-23-21-63-19-17-47-33-9-7-8-32-38(33)44(60)53(43(32)59)34-15-16-37(56)51-42(34)58/h7-9,11-14,27,31,34-35,40,47,54H,5-6,10,15-26H2,1-4H3,(H,48,57)(H,50,55)(H,51,56,58)/t31-,34?,35+,40-/m1/s1","WUEVGEJGJVGIOU-IINAPWRYSA-N"
"176","Q96SW2","CRBN","VHL","","CRBN-6-5-5-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOCCCCCOCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","1.5","","Degradation of CRBN in MM1S cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","972.219","971.482662408","5.6","69","6","13","5","26","225.67","C51H69N7O10S","InChI=1S/C51H69N7O10S/c1-33-44(69-32-54-33)35-20-18-34(19-21-35)30-53-46(62)40-29-36(59)31-57(40)50(66)45(51(2,3)4)55-41(60)17-8-13-28-68-27-12-7-11-26-67-25-10-6-5-9-24-52-38-16-14-15-37-43(38)49(65)58(48(37)64)39-22-23-42(61)56-47(39)63/h14-16,18-21,32,36,39-40,45,52,59H,5-13,17,22-31H2,1-4H3,(H,53,62)(H,55,60)(H,56,61,63)/t36-,39?,40+,45-/m1/s1","LIMCHOLAKDUZDS-XARBDFOFSA-N"
"177","Q96SW2","CRBN","VHL","","CRBN-6-6-6-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOCCCCCCOCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","1000.273","999.513962536","6.31","71","6","13","5","28","225.67","C53H73N7O10S","InChI=1S/C53H73N7O10S/c1-35-46(71-34-56-35)37-22-20-36(21-23-37)32-55-48(64)42-31-38(61)33-59(42)52(68)47(53(2,3)4)57-43(62)19-10-9-15-30-70-29-14-8-7-13-28-69-27-12-6-5-11-26-54-40-18-16-17-39-45(40)51(67)60(50(39)66)41-24-25-44(63)58-49(41)65/h16-18,20-23,34,38,41-42,47,54,61H,5-15,19,24-33H2,1-4H3,(H,55,64)(H,57,62)(H,58,63,65)/t38-,41?,42+,47-/m1/s1","LYMJPQPTPZAHGL-ACUWCQIBSA-N"
"178","Q96SW2","CRBN","VHL","","CRBN-4-4-4-6-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","1016.272","1015.50887716","5.45","72","6","14","5","29","234.9","C53H73N7O11S","InChI=1S/C53H73N7O11S/c1-35-46(72-34-56-35)37-20-18-36(19-21-37)32-55-48(64)42-31-38(61)33-59(42)52(68)47(53(2,3)4)57-43(62)17-6-5-8-25-69-27-10-12-29-71-30-13-11-28-70-26-9-7-24-54-40-16-14-15-39-45(40)51(67)60(50(39)66)41-22-23-44(63)58-49(41)65/h14-16,18-21,34,38,41-42,47,54,61H,5-13,17,22-33H2,1-4H3,(H,55,64)(H,57,62)(H,58,63,65)/t38-,41?,42+,47-/m1/s1","IFGDABAFOYMULB-ACUWCQIBSA-N"
"179","Q96SW2","CRBN","VHL","","CRBN-6-(2)5-6-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOCCOCCOCCOCCOCCOCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","1120.377","1119.55622127","4.29","79","6","17","5","36","262.59","C57H81N7O14S","InChI=1S/C57H81N7O14S/c1-39-50(79-38-60-39)41-18-16-40(17-19-41)36-59-52(68)46-35-42(65)37-63(46)56(72)51(57(2,3)4)61-47(66)15-8-7-11-24-74-26-28-76-30-32-78-34-33-77-31-29-75-27-25-73-23-10-6-5-9-22-58-44-14-12-13-43-49(44)55(71)64(54(43)70)45-20-21-48(67)62-53(45)69/h12-14,16-19,38,42,45-46,51,58,65H,5-11,15,20-37H2,1-4H3,(H,59,68)(H,61,66)(H,62,67,69)/t42-,45?,46+,51-/m1/s1","LVSYIZUWFJOMFT-CDRPTVBDSA-N"
"180","Q96SW2","CRBN","VHL","","CRBN-6-(4)3-6-VHL","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOCCCCOCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc09541h","1116.433","1115.59769216","6.73","79","6","15","5","36","244.13","C59H85N7O12S","InChI=1S/C59H85N7O12S/c1-41-52(79-40-62-41)43-24-22-42(23-25-43)38-61-54(70)48-37-44(67)39-65(48)58(74)53(59(2,3)4)63-49(68)21-8-7-11-30-76-32-13-15-34-78-36-17-16-35-77-33-14-12-31-75-29-10-6-5-9-28-60-46-20-18-19-45-51(46)57(73)66(56(45)72)47-26-27-50(69)64-55(47)71/h18-20,22-25,40,44,47-48,53,60,67H,5-17,21,26-39H2,1-4H3,(H,61,70)(H,63,68)(H,64,69,71)/t44-,47?,48+,53-/m1/s1","XXNCDKYJJAUXRQ-XYJNTTBLSA-N"
"181","Q16539","p38alpha","VHL","","SJF-6693","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","40.1","92.6","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1078.205","1077.41178321","7.21","77","8","14","5","23","228.87","C56H61F2N7O11S","InChI=1S/C56H61F2N7O11S/c1-33-49(77-32-61-33)35-8-6-34(7-9-35)30-60-51(68)43-27-39(66)31-65(43)52(69)50(55(2,3)4)64-48(67)17-21-73-22-23-74-24-25-75-47-29-42-40(28-46(47)72-5)44(16-20-59-42)76-45-15-14-38(26-41(45)58)63-54(71)56(18-19-56)53(70)62-37-12-10-36(57)11-13-37/h6-16,20,26,28-29,32,39,43,50,66H,17-19,21-25,27,30-31H2,1-5H3,(H,60,68)(H,62,70)(H,63,71)(H,64,67)/t39-,43+,50-/m1/s1","FCEBHUUCGVQXGJ-XPMRVQNBSA-N"
"181","O15264","p38delta","VHL","","SJF-6693","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","51.4","81.8","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1078.205","1077.41178321","7.21","77","8","14","5","23","228.87","C56H61F2N7O11S","InChI=1S/C56H61F2N7O11S/c1-33-49(77-32-61-33)35-8-6-34(7-9-35)30-60-51(68)43-27-39(66)31-65(43)52(69)50(55(2,3)4)64-48(67)17-21-73-22-23-74-24-25-75-47-29-42-40(28-46(47)72-5)44(16-20-59-42)76-45-15-14-38(26-41(45)58)63-54(71)56(18-19-56)53(70)62-37-12-10-36(57)11-13-37/h6-16,20,26,28-29,32,39,43,50,66H,17-19,21-25,27,30-31H2,1-5H3,(H,60,68)(H,62,70)(H,63,71)(H,64,67)/t39-,43+,50-/m1/s1","FCEBHUUCGVQXGJ-XPMRVQNBSA-N"
"182","Q16539","p38alpha","VHL","","SJF-6690","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","18.8","99.4","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1092.232","1091.42743328","7.57","78","8","14","5","24","228.87","C57H63F2N7O11S","InChI=1S/C57H63F2N7O11S/c1-34-50(78-33-62-34)36-9-7-35(8-10-36)31-61-52(69)44-28-40(67)32-66(44)53(70)51(56(2,3)4)65-49(68)18-24-75-26-25-74-22-6-23-76-48-30-43-41(29-47(48)73-5)45(17-21-60-43)77-46-16-15-39(27-42(46)59)64-55(72)57(19-20-57)54(71)63-38-13-11-37(58)12-14-38/h7-17,21,27,29-30,33,40,44,51,67H,6,18-20,22-26,28,31-32H2,1-5H3,(H,61,69)(H,63,71)(H,64,72)(H,65,68)/t40-,44+,51-/m1/s1","PCRYOGWRHSLIEZ-XZVMHGATSA-N"
"182","O15264","p38delta","VHL","","SJF-6690","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","91.7","96.7","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1092.232","1091.42743328","7.57","78","8","14","5","24","228.87","C57H63F2N7O11S","InChI=1S/C57H63F2N7O11S/c1-34-50(78-33-62-34)36-9-7-35(8-10-36)31-61-52(69)44-28-40(67)32-66(44)53(70)51(56(2,3)4)65-49(68)18-24-75-26-25-74-22-6-23-76-48-30-43-41(29-47(48)73-5)45(17-21-60-43)77-46-16-15-39(27-42(46)59)64-55(72)57(19-20-57)54(71)63-38-13-11-37(58)12-14-38/h7-17,21,27,29-30,33,40,44,51,67H,6,18-20,22-26,28,31-32H2,1-5H3,(H,61,69)(H,63,71)(H,64,72)(H,65,68)/t40-,44+,51-/m1/s1","PCRYOGWRHSLIEZ-XZVMHGATSA-N"
"183","P08581","c-Met","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","66.7","Inhibit proliferation of GTL16 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","P08581","c-Met","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","310","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","O15264","p38delta","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","11000","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","O43353","RIPK2","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","1600","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","Q16539","p38alpha","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","230","90.1","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","Q16539","p38alpha","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","210","91","Degradation of p38alpha in MDA-MB-231 cells after 24 h treatment","","","","","","","5300","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"183","O15264","p38delta","VHL","","SJF-8240","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","456","54.3","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1106.259","1105.44308334","7.93","79","8","14","5","25","228.87","C58H65F2N7O11S","InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-63-35)37-10-8-36(9-11-37)32-62-53(70)45-29-41(68)33-67(45)54(71)52(57(2,3)4)66-50(69)19-27-76-24-6-23-75-25-7-26-77-49-31-44-42(30-48(49)74-5)46(18-22-61-44)78-47-17-16-40(28-43(47)60)65-56(73)58(20-21-58)55(72)64-39-14-12-38(59)13-15-39/h8-18,22,28,30-31,34,41,45,52,68H,6-7,19-21,23-27,29,32-33H2,1-5H3,(H,62,70)(H,64,72)(H,65,73)(H,66,69)/t41-,45+,52-/m1/s1","SCUZPTNDZHEHLB-ZWUDBOSPSA-N"
"184","Q16539","p38alpha","VHL","","SJF-6696","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCCOCCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","9.5","99.6","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1120.286","1119.4587334","8.74","80","8","14","5","26","228.87","C59H67F2N7O11S","InChI=1S/C59H67F2N7O11S/c1-36-52(80-35-64-36)38-12-10-37(11-13-38)32-63-54(71)46-29-42(69)33-68(46)55(72)53(58(2,3)4)67-51(70)34-77-26-7-6-24-76-25-8-9-27-78-50-31-45-43(30-49(50)75-5)47(20-23-62-45)79-48-19-18-41(28-44(48)61)66-57(74)59(21-22-59)56(73)65-40-16-14-39(60)15-17-40/h10-20,23,28,30-31,35,42,46,53,69H,6-9,21-22,24-27,29,32-34H2,1-5H3,(H,63,71)(H,65,73)(H,66,74)(H,67,70)/t42-,46+,53-/m1/s1","GXDYWQXTEYENEU-WFYKIECOSA-N"
"184","O15264","p38delta","VHL","","SJF-6696","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCCOCCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","1160","25.1","Degradation of p38delta in MDA-MB-231 cells","","","","","","","500","SPR","","","","","","","","","","","","","","","5000","SPR","","","","","","","","","","","","","","","1200","SPR","","","","","","","70100","0.072","8","SPR","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1120.286","1119.4587334","8.74","80","8","14","5","26","228.87","C59H67F2N7O11S","InChI=1S/C59H67F2N7O11S/c1-36-52(80-35-64-36)38-12-10-37(11-13-38)32-63-54(71)46-29-42(69)33-68(46)55(72)53(58(2,3)4)67-51(70)34-77-26-7-6-24-76-25-8-9-27-78-50-31-45-43(30-49(50)75-5)47(20-23-62-45)79-48-19-18-41(28-44(48)61)66-57(74)59(21-22-59)56(73)65-40-16-14-39(60)15-17-40/h10-20,23,28,30-31,35,42,46,53,69H,6-9,21-22,24-27,29,32-34H2,1-5H3,(H,63,71)(H,65,73)(H,66,74)(H,67,70)/t42-,46+,53-/m1/s1","GXDYWQXTEYENEU-WFYKIECOSA-N"
"185","Q16539","p38alpha","VHL","","SJF-6683","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCOCCOCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","45.9","34.5","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1168.286","1167.4223479","8.27","84","10","15","4","25","229.31","C62H63F2N7O12S","InChI=1S/C62H63F2N7O12S/c1-36(2)55(71-33-40-7-5-6-8-45(40)58(71)74)59(75)70-34-44(72)29-49(70)57(73)66-32-39-10-9-38(56-37(3)67-35-84-56)27-52(39)81-25-23-79-21-22-80-24-26-82-54-31-48-46(30-53(54)78-4)50(17-20-65-48)83-51-16-15-43(28-47(51)64)69-61(77)62(18-19-62)60(76)68-42-13-11-41(63)12-14-42/h5-17,20,27-28,30-31,35-36,44,49,55,72H,18-19,21-26,29,32-34H2,1-4H3,(H,66,73)(H,68,76)(H,69,77)/t44-,49+,55+/m1/s1","LYUUIIZKBMBNQV-CHOFKVETSA-N"
"185","O15264","p38delta","VHL","","SJF-6683","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCOCCOCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","79.2","98.4","Degradation of p38delta in MDA-MB-231 cells","","","","","","","550","SPR","","","","","","","","","","","","","","","3500","SPR","","","","","","","","","","","","","","","436","SPR","","","","","","","39600","0.018","38","SPR","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1168.286","1167.4223479","8.27","84","10","15","4","25","229.31","C62H63F2N7O12S","InChI=1S/C62H63F2N7O12S/c1-36(2)55(71-33-40-7-5-6-8-45(40)58(71)74)59(75)70-34-44(72)29-49(70)57(73)66-32-39-10-9-38(56-37(3)67-35-84-56)27-52(39)81-25-23-79-21-22-80-24-26-82-54-31-48-46(30-53(54)78-4)50(17-20-65-48)83-51-16-15-43(28-47(51)64)69-61(77)62(18-19-62)60(76)68-42-13-11-41(63)12-14-42/h5-17,20,27-28,30-31,35-36,44,49,55,72H,18-19,21-26,29,32-34H2,1-4H3,(H,66,73)(H,68,76)(H,69,77)/t44-,49+,55+/m1/s1","LYUUIIZKBMBNQV-CHOFKVETSA-N"
"186","Q16539","p38alpha","VHL","","SJF-6677","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCCOCCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","127","25.3","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1180.341","1179.4587334","9.84","85","10","14","4","26","220.08","C64H67F2N7O11S","InChI=1S/C64H67F2N7O11S/c1-38(2)57(73-35-42-11-5-6-12-47(42)60(73)76)61(77)72-36-46(74)31-51(72)59(75)68-34-41-14-13-40(58-39(3)69-37-85-58)29-54(41)82-27-9-7-25-81-26-8-10-28-83-56-33-50-48(32-55(56)80-4)52(21-24-67-50)84-53-20-19-45(30-49(53)66)71-63(79)64(22-23-64)62(78)70-44-17-15-43(65)16-18-44/h5-6,11-21,24,29-30,32-33,37-38,46,51,57,74H,7-10,22-23,25-28,31,34-36H2,1-4H3,(H,68,75)(H,70,78)(H,71,79)/t46-,51+,57+/m1/s1","LCBLIBYLVHDHMI-JCYIICMFSA-N"
"186","O15264","p38delta","VHL","","SJF-6677","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCCOCCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","106","43.5","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1180.341","1179.4587334","9.84","85","10","14","4","26","220.08","C64H67F2N7O11S","InChI=1S/C64H67F2N7O11S/c1-38(2)57(73-35-42-11-5-6-12-47(42)60(73)76)61(77)72-36-46(74)31-51(72)59(75)68-34-41-14-13-40(58-39(3)69-37-85-58)29-54(41)82-27-9-7-25-81-26-8-10-28-83-56-33-50-48(32-55(56)80-4)52(21-24-67-50)84-53-20-19-45(30-49(53)66)71-63(79)64(22-23-64)62(78)70-44-17-15-43(65)16-18-44/h5-6,11-21,24,29-30,32-33,37-38,46,51,57,74H,7-10,22-23,25-28,31,34-36H2,1-4H3,(H,68,75)(H,70,78)(H,71,79)/t46-,51+,57+/m1/s1","LCBLIBYLVHDHMI-JCYIICMFSA-N"
"187","Q16539","p38alpha","VHL","","BES-4612","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCOCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","760","16.8","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1196.34","1195.45364802","8.98","86","10","15","4","27","229.31","C64H67F2N7O12S","InChI=1S/C64H67F2N7O12S/c1-38(2)57(73-35-42-9-5-6-10-47(42)60(73)76)61(77)72-36-46(74)31-51(72)59(75)68-34-41-12-11-40(58-39(3)69-37-86-58)29-54(41)83-25-7-23-81-27-28-82-24-8-26-84-56-33-50-48(32-55(56)80-4)52(19-22-67-50)85-53-18-17-45(30-49(53)66)71-63(79)64(20-21-64)62(78)70-44-15-13-43(65)14-16-44/h5-6,9-19,22,29-30,32-33,37-38,46,51,57,74H,7-8,20-21,23-28,31,34-36H2,1-4H3,(H,68,75)(H,70,78)(H,71,79)/t46-,51+,57+/m1/s1","RZMAGXNWPGZVNP-JCYIICMFSA-N"
"187","O15264","p38delta","VHL","","BES-4612","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCOCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","1890","78.7","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1196.34","1195.45364802","8.98","86","10","15","4","27","229.31","C64H67F2N7O12S","InChI=1S/C64H67F2N7O12S/c1-38(2)57(73-35-42-9-5-6-10-47(42)60(73)76)61(77)72-36-46(74)31-51(72)59(75)68-34-41-12-11-40(58-39(3)69-37-86-58)29-54(41)83-25-7-23-81-27-28-82-24-8-26-84-56-33-50-48(32-55(56)80-4)52(19-22-67-50)85-53-18-17-45(30-49(53)66)71-63(79)64(20-21-64)62(78)70-44-15-13-43(65)14-16-44/h5-6,9-19,22,29-30,32-33,37-38,46,51,57,74H,7-8,20-21,23-28,31,34-36H2,1-4H3,(H,68,75)(H,70,78)(H,71,79)/t46-,51+,57+/m1/s1","RZMAGXNWPGZVNP-JCYIICMFSA-N"
"188","Q16539","p38alpha","VHL","","SJF-6685","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","304","19.9","Degradation of p38alpha in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1210.367","1209.46929809","9.34","87","10","15","4","28","229.31","C65H69F2N7O12S","InChI=1S/C65H69F2N7O12S/c1-39(2)58(74-36-43-10-5-6-11-48(43)61(74)77)62(78)73-37-47(75)32-52(73)60(76)69-35-42-13-12-41(59-40(3)70-38-87-59)30-55(42)84-28-8-26-82-24-7-25-83-27-9-29-85-57-34-51-49(33-56(57)81-4)53(20-23-68-51)86-54-19-18-46(31-50(54)67)72-64(80)65(21-22-65)63(79)71-45-16-14-44(66)15-17-45/h5-6,10-20,23,30-31,33-34,38-39,47,52,58,75H,7-9,21-22,24-29,32,35-37H2,1-4H3,(H,69,76)(H,71,79)(H,72,80)/t47-,52+,58+/m1/s1","LVQCYBJKHQGJSR-LVSOZEIGSA-N"
"188","O15264","p38delta","VHL","","SJF-6685","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1CC2=CC=CC=C2C1=O","1140","33.5","Degradation of p38delta in MDA-MB-231 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-018-08027-7","1210.367","1209.46929809","9.34","87","10","15","4","28","229.31","C65H69F2N7O12S","InChI=1S/C65H69F2N7O12S/c1-39(2)58(74-36-43-10-5-6-11-48(43)61(74)77)62(78)73-37-47(75)32-52(73)60(76)69-35-42-13-12-41(59-40(3)70-38-87-59)30-55(42)84-28-8-26-82-24-7-25-83-27-9-29-85-57-34-51-49(33-56(57)81-4)53(20-23-68-51)86-54-19-18-46(31-50(54)67)72-64(80)65(21-22-65)63(79)71-45-16-14-44(66)15-17-45/h5-6,10-20,23,30-31,33-34,38-39,47,52,58,75H,7-9,21-22,24-29,32,35-37H2,1-4H3,(H,69,76)(H,71,79)(H,72,80)/t47-,52+,58+/m1/s1","LVQCYBJKHQGJSR-LVSOZEIGSA-N"
"189","P11802","CDK4","CRBN","","CP-11","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)24-35(57)45-17-6-5-16-44-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,44H,3-6,8-9,13,15-21,24H2,1-2H3,(H,45,57)(H,49,56,58)(H,46,47,48,50)","ZDYIWDFMTLECCN-UHFFFAOYSA-N"
"189","Q00534","CDK6","CRBN","","CP-11","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)24-35(57)45-17-6-5-16-44-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,44H,3-6,8-9,13,15-21,24H2,1-2H3,(H,45,57)(H,49,56,58)(H,46,47,48,50)","ZDYIWDFMTLECCN-UHFFFAOYSA-N"
"190","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.03.035","888.043","887.444243164","4.57","65","8","15","4","18","220.93","C47H57N11O7","InChI=1S/C47H57N11O7/c1-29-34-27-51-47(54-42(34)57(31-12-7-8-13-31)45(64)40(29)30(2)59)52-37-18-16-32(26-50-37)56-24-22-55(23-25-56)28-39(61)49-21-10-6-4-3-5-9-20-48-35-15-11-14-33-41(35)46(65)58(44(33)63)36-17-19-38(60)53-43(36)62/h11,14-16,18,26-27,31,36,48H,3-10,12-13,17,19-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","JWWJOXYINXWNGC-UHFFFAOYSA-N"
"191","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.03.035","816.92","816.370743876","2.91","60","8","14","3","13","208.9","C43H48N10O7","InChI=1S/C43H48N10O7/c1-25-30-24-45-43(49-38(30)52(27-9-5-6-10-27)41(59)36(25)26(2)54)47-33-16-14-28(23-44-33)51-21-19-50(20-22-51)18-7-3-4-13-34(55)46-31-12-8-11-29-37(31)42(60)53(40(29)58)32-15-17-35(56)48-39(32)57/h8,11-12,14,16,23-24,27,32H,3-7,9-10,13,15,17-22H2,1-2H3,(H,46,55)(H,48,56,57)(H,44,45,47,49)","HJEZCPKGRBNZSZ-UHFFFAOYSA-N"
"192","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.03.035","835.919","835.365324148","1.86","61","8","16","2","16","207.49","C43H49N9O9","InChI=1S/C43H49N9O9/c1-26-31-25-45-43(48-38(31)51(28-6-3-4-7-28)41(57)36(26)27(2)53)46-34-12-10-29(24-44-34)50-16-14-49(15-17-50)18-19-59-20-21-60-22-23-61-33-9-5-8-30-37(33)42(58)52(40(30)56)32-11-13-35(54)47-39(32)55/h5,8-10,12,24-25,28,32H,3-4,6-7,11,13-23H2,1-2H3,(H,47,54,55)(H,44,45,46,48)","SFFDQTCEQLEBDF-UHFFFAOYSA-N"
"193","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCOCCOCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","6.61","Inhibition of CDK6/Cyciln D3 by cell-free kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.03.035","964.094","963.460287152","2.33","70","8","18","4","23","248.62","C49H61N11O10","InChI=1S/C49H61N11O10/c1-31-36-29-53-49(56-44(36)59(33-8-3-4-9-33)47(66)42(31)32(2)61)54-39-14-12-34(28-52-39)58-20-18-57(19-21-58)30-41(63)51-17-7-23-69-25-27-70-26-24-68-22-6-16-50-37-11-5-10-35-43(37)48(67)60(46(35)65)38-13-15-40(62)55-45(38)64/h5,10-12,14,28-29,33,38,50H,3-4,6-9,13,15-27,30H2,1-2H3,(H,51,63)(H,55,62,64)(H,52,53,54,56)","NAENXYHPJLZWFB-UHFFFAOYSA-N"
"194","P25440","BRD2","CRBN","","SIAIS213110","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","<0.5","","Degradation of BRD2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.7/0.9/125.4","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","727.291","726.250350408","4.3","51","7","10","3","11","150.68","C37H39ClN8O4S","InChI=1S/C37H39ClN8O4S/c1-20-21(2)51-37-32(20)33(23-10-12-24(38)13-11-23)41-28(34-44-43-22(3)46(34)37)18-31(48)40-17-6-4-5-16-39-27-9-7-8-25-26(27)19-45(36(25)50)29-14-15-30(47)42-35(29)49/h7-13,28-29,39H,4-6,14-19H2,1-3H3,(H,40,48)(H,42,47,49)/t28-,29?/m0/s1","UYBVSBAZZWUPHH-XLTVJXRZSA-N"
"194","Q15059","BRD3","CRBN","","SIAIS213110","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","<0.5","","Degradation of BRD3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.7/0.9/125.4","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","727.291","726.250350408","4.3","51","7","10","3","11","150.68","C37H39ClN8O4S","InChI=1S/C37H39ClN8O4S/c1-20-21(2)51-37-32(20)33(23-10-12-24(38)13-11-23)41-28(34-44-43-22(3)46(34)37)18-31(48)40-17-6-4-5-16-39-27-9-7-8-25-26(27)19-45(36(25)50)29-14-15-30(47)42-35(29)49/h7-13,28-29,39H,4-6,14-19H2,1-3H3,(H,40,48)(H,42,47,49)/t28-,29?/m0/s1","UYBVSBAZZWUPHH-XLTVJXRZSA-N"
"194","O60885","BRD4","CRBN","","SIAIS213110","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","<0.5","","Degradation of BRD4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.7/0.9/125.4","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","727.291","726.250350408","4.3","51","7","10","3","11","150.68","C37H39ClN8O4S","InChI=1S/C37H39ClN8O4S/c1-20-21(2)51-37-32(20)33(23-10-12-24(38)13-11-23)41-28(34-44-43-22(3)46(34)37)18-31(48)40-17-6-4-5-16-39-27-9-7-8-25-26(27)19-45(36(25)50)29-14-15-30(47)42-35(29)49/h7-13,28-29,39H,4-6,14-19H2,1-3H3,(H,40,48)(H,42,47,49)/t28-,29?/m0/s1","UYBVSBAZZWUPHH-XLTVJXRZSA-N"
"195","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","28/50","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","7.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","928.953","928.305288132","6.78","65","5","10","4","15","182.98","C45H46F6N6O7S","InChI=1S/C45H46F6N6O7S/c1-25-38(65-24-55-25)28-9-6-26(7-10-28)21-54-41(61)34-19-32(58)22-57(34)42(62)39(43(2,3)4)56-37(59)14-15-53-40(60)30(20-52)16-27-8-13-35(36(17-27)63-5)64-23-29-11-12-31(44(46,47)48)18-33(29)45(49,50)51/h6-13,16-18,24,32,34,39,58H,14-15,19,21-23H2,1-5H3,(H,53,60)(H,54,61)(H,56,59)/b30-16+/t32-,34+,39-/m1/s1","GXIDZUOKFMNGIA-FEWVHYGASA-N"
"196","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","58/85","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","6.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","942.98","942.320938196","7.13","66","5","10","4","16","182.98","C46H48F6N6O7S","InChI=1S/C46H48F6N6O7S/c1-26-39(66-25-56-26)29-11-8-27(9-12-29)22-55-42(62)35-20-33(59)23-58(35)43(63)40(44(2,3)4)57-38(60)7-6-16-54-41(61)31(21-53)17-28-10-15-36(37(18-28)64-5)65-24-30-13-14-32(45(47,48)49)19-34(30)46(50,51)52/h8-15,17-19,25,33,35,40,59H,6-7,16,20,22-24H2,1-5H3,(H,54,61)(H,55,62)(H,57,60)/b31-17+/t33-,35+,40-/m1/s1","OWPXBBYFUGODAK-KBNFCJHUSA-N"
"197","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","39/83/96","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 10/30/100 nM","12.67","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","957.007","956.33658826","7.49","67","5","10","4","17","182.98","C47H50F6N6O7S","InChI=1S/C47H50F6N6O7S/c1-27-40(67-26-57-27)30-12-9-28(10-13-30)23-56-43(63)36-21-34(60)24-59(36)44(64)41(45(2,3)4)58-39(61)8-6-7-17-55-42(62)32(22-54)18-29-11-16-37(38(19-29)65-5)66-25-31-14-15-33(46(48,49)50)20-35(31)47(51,52)53/h9-16,18-20,26,34,36,41,60H,6-8,17,21,23-25H2,1-5H3,(H,55,62)(H,56,63)(H,58,61)/b32-18+/t34-,36+,41-/m1/s1","POTUUCUOBIVSIX-BDUCEWPUSA-N"
"198","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","58/78","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","5.67","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","971.034","970.352238324","7.85","68","5","10","4","18","182.98","C48H52F6N6O7S","InChI=1S/C48H52F6N6O7S/c1-28-41(68-27-58-28)31-13-10-29(11-14-31)24-57-44(64)37-22-35(61)25-60(37)45(65)42(46(2,3)4)59-40(62)9-7-6-8-18-56-43(63)33(23-55)19-30-12-17-38(39(20-30)66-5)67-26-32-15-16-34(47(49,50)51)21-36(32)48(52,53)54/h10-17,19-21,27,35,37,42,61H,6-9,18,22,24-26H2,1-5H3,(H,56,63)(H,57,64)(H,59,62)/b33-19+/t35-,37+,42-/m1/s1","REDUTJVDNZYVPL-CKGBFGRYSA-N"
"199","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","23/71","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","12.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","985.061","984.367888388","8.39","69","5","10","4","19","182.98","C49H54F6N6O7S","InChI=1S/C49H54F6N6O7S/c1-29-42(69-28-59-29)32-14-11-30(12-15-32)25-58-45(65)38-23-36(62)26-61(38)46(66)43(47(2,3)4)60-41(63)10-8-6-7-9-19-57-44(64)34(24-56)20-31-13-18-39(40(21-31)67-5)68-27-33-16-17-35(48(50,51)52)22-37(33)49(53,54)55/h11-18,20-22,28,36,38,43,62H,6-10,19,23,25-27H2,1-5H3,(H,57,64)(H,58,65)(H,60,63)/b34-20+/t36-,38+,43-/m1/s1","IKHNJLBBNYYHOX-SYJKBDHJSA-N"
"200","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","3/9","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","7.67","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","999.088","998.383538452","8.93","70","5","10","4","20","182.98","C50H56F6N6O7S","InChI=1S/C50H56F6N6O7S/c1-30-43(70-29-60-30)33-15-12-31(13-16-33)26-59-46(66)39-24-37(63)27-62(39)47(67)44(48(2,3)4)61-42(64)11-9-7-6-8-10-20-58-45(65)35(25-57)21-32-14-19-40(41(22-32)68-5)69-28-34-17-18-36(49(51,52)53)23-38(34)50(54,55)56/h12-19,21-23,29,37,39,44,63H,6-11,20,24,26-28H2,1-5H3,(H,58,65)(H,59,66)(H,61,64)/b35-21+/t37-,39+,44-/m1/s1","RNNKZQWFHJOWDN-UZPTXCMLSA-N"
"201","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","79/92","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100 nM","11.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","958.979","958.315852816","6.73","67","5","11","4","17","192.21","C46H48F6N6O8S","InChI=1S/C46H48F6N6O8S/c1-26-39(67-25-56-26)29-9-6-27(7-10-29)21-55-42(62)35-19-33(59)22-58(35)43(63)40(44(2,3)4)57-38(60)24-65-15-14-54-41(61)31(20-53)16-28-8-13-36(37(17-28)64-5)66-23-30-11-12-32(45(47,48)49)18-34(30)46(50,51)52/h6-13,16-18,25,33,35,40,59H,14-15,19,21-24H2,1-5H3,(H,54,61)(H,55,62)(H,57,60)/b31-16+/t33-,35+,40-/m1/s1","MURXQKJPAHTLRI-IMYKHKJASA-N"
"202","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","25/63/89","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 10/30/100 nM","9.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","973.006","972.33150288","6.63","68","5","11","4","18","192.21","C47H50F6N6O8S","InChI=1S/C47H50F6N6O8S/c1-27-40(68-26-57-27)30-9-6-28(7-10-30)23-56-43(63)36-21-34(60)24-59(36)44(64)41(45(2,3)4)58-39(61)14-16-66-17-15-55-42(62)32(22-54)18-29-8-13-37(38(19-29)65-5)67-25-31-11-12-33(46(48,49)50)20-35(31)47(51,52)53/h6-13,18-20,26,34,36,41,60H,14-17,21,23-25H2,1-5H3,(H,55,62)(H,56,63)(H,58,61)/b32-18+/t34-,36+,41-/m1/s1","IDGWXLXTBJVQIE-BDUCEWPUSA-N"
"203","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","0/15/19","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100/300 nM","5.33","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","1017.059","1016.35771763","6.48","71","5","12","4","21","201.44","C49H54F6N6O9S","InChI=1S/C49H54F6N6O9S/c1-29-42(71-28-59-29)32-9-6-30(7-10-32)25-58-45(65)38-23-36(62)26-61(38)46(66)43(47(2,3)4)60-41(63)14-16-68-18-19-69-17-15-57-44(64)34(24-56)20-31-8-13-39(40(21-31)67-5)70-27-33-11-12-35(48(50,51)52)22-37(33)49(53,54)55/h6-13,20-22,28,36,38,43,62H,14-19,23,25-27H2,1-5H3,(H,57,64)(H,58,65)(H,60,63)/b34-20+/t36-,38+,43-/m1/s1","SJHLGXTZTYFQQR-SYJKBDHJSA-N"
"204","P11474","ERRalpha","VHL","","","COC1=CC(/C=C(\C#N)C(=O)NCCOCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1OCC1=CC=C(C(F)(F)F)C=C1C(F)(F)F","","","","0/4/10","% ERRalpha degradation in MDA-MB-231 cells after 4 h treatment at 30/100/300 nM","7","Inhibition of ERRalpha by TR-FRET Coactivator Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00025","1061.112","1060.38393238","6.33","74","5","13","4","24","210.67","C51H58F6N6O10S","InChI=1S/C51H58F6N6O10S/c1-31-44(74-30-61-31)34-9-6-32(7-10-34)27-60-47(67)40-25-38(64)28-63(40)48(68)45(49(2,3)4)62-43(65)14-16-70-18-20-72-21-19-71-17-15-59-46(66)36(26-58)22-33-8-13-41(42(23-33)69-5)73-29-35-11-12-37(50(52,53)54)24-39(35)51(55,56)57/h6-13,22-24,30,38,40,45,64H,14-21,25,27-29H2,1-5H3,(H,59,66)(H,60,67)(H,62,65)/b36-22+/t38-,40+,45-/m1/s1","MVFPCDPEAWPGQF-YYFRRMCLSA-N"
"205","Q06187","BTK","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(CC(=O)NCCOCCOCC(=O)NCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","159","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc08716d","932.992","932.381702484","1.64","68","8","17","4","22","260.76","C47H52N10O11","InChI=1S/C47H52N10O11/c48-43-41-42(30-11-13-33(14-12-30)68-32-7-2-1-3-8-32)54-57(44(41)52-29-51-43)31-6-5-19-55(26-31)27-38(59)49-17-20-64-22-23-66-28-39(60)50-18-21-65-24-25-67-36-10-4-9-34-40(36)47(63)56(46(34)62)35-15-16-37(58)53-45(35)61/h1-4,7-14,29,31,35H,5-6,15-28H2,(H,49,59)(H,50,60)(H2,48,51,52)(H,53,58,61)/t31-,35?/m1/s1","PXDCSFBHRBQAHO-ZCODOFFGSA-N"
"206","Q06187","BTK","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(CC(=O)NCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","102","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc08716d","787.834","787.307809272","2.59","58","8","14","3","14","213.2","C41H41N9O8","InChI=1S/C41H41N9O8/c42-37-35-36(25-11-13-28(14-12-25)58-27-7-2-1-3-8-27)47-50(38(35)45-24-44-37)26-6-5-18-48(22-26)23-33(52)43-17-19-56-20-21-57-31-10-4-9-29-34(31)41(55)49(40(29)54)30-15-16-32(51)46-39(30)53/h1-4,7-14,24,26,30H,5-6,15-23H2,(H,43,52)(H2,42,44,45)(H,46,51,53)/t26-,30?/m1/s1","RRWQTBFVBDAZFX-FIQOPJFZSA-N"
"207","Q06187","BTK","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(CC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","108","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c8cc08716d","1078.15","1077.4555957","0.69","78","8","20","5","30","308.32","C53H63N11O14","InChI=1S/C53H63N11O14/c54-49-47-48(35-11-13-38(14-12-35)78-37-7-2-1-3-8-37)61-64(50(47)59-34-58-49)36-6-5-20-62(30-36)31-43(66)55-17-21-72-24-26-75-32-44(67)56-18-22-73-25-27-76-33-45(68)57-19-23-74-28-29-77-41-10-4-9-39-46(41)53(71)63(52(39)70)40-15-16-42(65)60-51(40)69/h1-4,7-14,34,36,40H,5-6,15-33H2,(H,55,66)(H,56,67)(H,57,68)(H2,54,58,59)(H,60,65,69)/t36-,40?/m1/s1","UGEHENLWTLZJFP-FGJFIXQTSA-N"
"208","O60885","BRD4","MDM2","","A1874","COC1=CC(C(=O)NCCOCCOCCOCCNC(=O)C[C@@H]2N=C(C3=CC=C(Cl)C=C3)C3=C(SC(C)=C3C)N3C(C)=NN=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","32","98","Degradation of BRD4 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","46.5/86.3/236","Inhibit viability of SJSA1/HCT116/A375 cells","","","","","","","","","","","","","","","10.1158/0008-5472.CAN-18-2918","1173.612","1171.3526558","8.94","80","8","14","4","22","203.11","C58H62Cl3F2N9O7S","InChI=1S/C58H62Cl3F2N9O7S/c1-32-33(2)80-56-48(32)51(35-11-14-37(59)15-12-35)67-44(53-71-70-34(3)72(53)56)29-47(73)65-19-21-77-23-25-79-26-24-78-22-20-66-54(74)36-13-18-43(45(27-36)76-7)68-55(75)52-49(39-9-8-10-41(61)50(39)63)58(31-64,46(69-52)30-57(4,5)6)40-17-16-38(60)28-42(40)62/h8-18,27-28,44,46,49,52,69H,19-26,29-30H2,1-7H3,(H,65,73)(H,66,74)(H,68,75)/t44-,46-,49-,52+,58-/m0/s1","IPNTVOAQOGRLQB-JJMBTQCASA-N"
"209","O60885","BRD4","VHL","","A743","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCOCCCOC3=CC=C(NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","23.1","89","Degradation of BRD4 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/0008-5472.CAN-18-2918","1092.786","1091.41642975","7.71","76","8","15","4","22","211.49","C56H66ClN9O8S2","InChI=1S/C56H66ClN9O8S2/c1-33-35(3)76-55-48(33)49(38-15-17-40(57)18-16-38)61-44(52-64-63-36(4)66(52)55)28-46(68)60-41-19-21-43(22-20-41)74-26-10-25-72-23-8-9-24-73-31-47(69)62-51(56(5,6)7)54(71)65-30-42(67)27-45(65)53(70)58-29-37-11-13-39(14-12-37)50-34(2)59-32-75-50/h11-22,32,42,44-45,51,67H,8-10,23-31H2,1-7H3,(H,58,70)(H,60,68)(H,62,69)/t42-,44+,45+,51-/m1/s1","LIRKMAWQWVEHBG-QEFNCWSLSA-N"
"210","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","","N.D.","","","","","","","","735","SPR","","","","","","","","","","","","","","","8000","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","756.723","756.246766488","3.5","55","7","12","4","10","221.28","C37H34F2N8O8","InChI=1S/C37H34F2N8O8/c38-20-8-12-27(24(39)17-20)55-22-9-6-19(7-10-22)31-30(33(41)49)32(40)47(44-31)21-3-2-15-45(18-21)37(53)54-16-14-42-25-5-1-4-23-29(25)36(52)46(35(23)51)26-11-13-28(48)43-34(26)50/h1,4-10,12,17,21,26,42H,2-3,11,13-16,18,40H2,(H2,41,49)(H,43,48,50)/t21-,26?/m1/s1","WPSYXPCVOWKVCC-OSMGYRLQSA-N"
"211","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)COCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","","N.D.","","","","","","","","1400","SPR","","","","","","","","","","","","","","","7600","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","770.75","770.262416552","2.98","56","7","12","4","12","221.28","C38H36F2N8O8","InChI=1S/C38H36F2N8O8/c39-21-8-12-28(25(40)17-21)56-23-9-6-20(7-10-23)33-32(35(42)51)34(41)48(45-33)22-3-2-15-46(18-22)30(50)19-55-16-14-43-26-5-1-4-24-31(26)38(54)47(37(24)53)27-11-13-29(49)44-36(27)52/h1,4-10,12,17,22,27,43H,2-3,11,13-16,18-19,41H2,(H2,42,51)(H,44,49,52)/t22-,27?/m1/s1","XAWAYTRJECSXEE-XVPAFAEQSA-N"
"212","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","","33/18","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","1535","SPR","","","","","","","","","","","","","","","15700","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","800.776","800.272981236","3.35","58","7","13","4","13","230.51","C39H38F2N8O9","InChI=1S/C39H38F2N8O9/c40-22-8-12-29(26(41)19-22)58-24-9-6-21(7-10-24)33-32(35(43)51)34(42)49(46-33)23-3-2-15-47(20-23)39(55)57-18-17-56-16-14-44-27-5-1-4-25-31(27)38(54)48(37(25)53)28-11-13-30(50)45-36(28)52/h1,4-10,12,19,23,28,44H,2-3,11,13-18,20,42H2,(H2,43,51)(H,45,50,52)/t23-,28?/m1/s1","QADIMDVHQUXGJB-YFIOFSHDSA-N"
"213","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)COCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","","34/15","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","489","SPR","","","","","","","","","","","","","","","5300","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","814.803","814.2886313","2.83","59","7","13","4","15","230.51","C40H40F2N8O9","InChI=1S/C40H40F2N8O9/c41-23-8-12-30(27(42)19-23)59-25-9-6-22(7-10-25)35-34(37(44)53)36(43)50(47-35)24-3-2-15-48(20-24)32(52)21-58-18-17-57-16-14-45-28-5-1-4-26-33(28)40(56)49(39(26)55)29-11-13-31(51)46-38(29)54/h1,4-10,12,19,24,29,45H,2-3,11,13-18,20-21,43H2,(H2,44,53)(H,46,51,54)/t24-,29?/m1/s1","BCFRPOBNUNJKGU-OEXUWWALSA-N"
"214","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","1487/(n/a)","64/36","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","1150","SPR","","","","","","","","","","","","","","","8800","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","844.829","844.299195984","3.2","61","7","14","4","16","239.74","C41H42F2N8O10","InChI=1S/C41H42F2N8O10/c42-24-8-12-31(28(43)21-24)61-26-9-6-23(7-10-26)35-34(37(45)53)36(44)51(48-35)25-3-2-15-49(22-25)41(57)60-20-19-59-18-17-58-16-14-46-29-5-1-4-27-33(29)40(56)50(39(27)55)30-11-13-32(52)47-38(30)54/h1,4-10,12,21,25,30,46H,2-3,11,13-20,22,44H2,(H2,45,53)(H,47,52,54)/t25-,30?/m1/s1","MAECKIKUFSSWJT-GOWJNXQMSA-N"
"215","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","36.9/398.5","85/68","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","71","SPR","","","","","","","","","","","","","","","2500","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","888.882","888.325410732","3.05","64","7","15","4","19","248.97","C43H46F2N8O11","InChI=1S/C43H46F2N8O11/c44-26-8-12-33(30(45)23-26)64-28-9-6-25(7-10-28)37-36(39(47)55)38(46)53(50-37)27-3-2-15-51(24-27)43(59)63-22-21-62-20-19-61-18-17-60-16-14-48-31-5-1-4-29-35(31)42(58)52(41(29)57)32-11-13-34(54)49-40(32)56/h1,4-10,12,23,27,32,48H,2-3,11,13-22,24,46H2,(H2,47,55)(H,49,54,56)/t27-,32?/m1/s1","IDIGRNKYBBGIKH-XIDOUCRZSA-N"
"216","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)COCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","21.8/469.9","84/63","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","79","SPR","","","","","","","","","","","","","","","2700","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","902.909","902.341060796","2.53","65","7","15","4","21","248.97","C44H48F2N8O11","InChI=1S/C44H48F2N8O11/c45-27-8-12-34(31(46)23-27)65-29-9-6-26(7-10-29)39-38(41(48)57)40(47)54(51-39)28-3-2-15-52(24-28)36(56)25-64-22-21-63-20-19-62-18-17-61-16-14-49-32-5-1-4-30-37(32)44(60)53(43(30)59)33-11-13-35(55)50-42(33)58/h1,4-10,12,23,28,33,49H,2-3,11,13-22,24-25,47H2,(H2,48,57)(H,50,55,58)/t28-,33?/m1/s1","PZNXLFVCWNTMGE-TUDONDPESA-N"
"217","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","4.5/90.5","87/75","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","80","SPR","","","","","","","","","","","","","","","3600","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","932.935","932.35162548","2.91","67","7","16","4","22","258.2","C45H50F2N8O12","InChI=1S/C45H50F2N8O12/c46-28-8-12-35(32(47)25-28)67-30-9-6-27(7-10-30)39-38(41(49)57)40(48)55(52-39)29-3-2-15-53(26-29)45(61)66-24-23-65-22-21-64-20-19-63-18-17-62-16-14-50-33-5-1-4-31-37(33)44(60)54(43(31)59)34-11-13-36(56)51-42(34)58/h1,4-10,12,25,29,34,50H,2-3,11,13-24,26,48H2,(H2,49,57)(H,51,56,58)/t29-,34?/m1/s1","HIEUPGKCAGGMLO-QMUARQKKSA-N"
"218","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)COCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","5.9/217.7","85/71","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","74","SPR","","","","","","","","","","","","","","","3200","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","946.962","946.367275544","2.39","68","7","16","4","24","258.2","C46H52F2N8O12","InChI=1S/C46H52F2N8O12/c47-29-8-12-36(33(48)25-29)68-31-9-6-28(7-10-31)41-40(43(50)59)42(49)56(53-41)30-3-2-15-54(26-30)38(58)27-67-24-23-66-22-21-65-20-19-64-18-17-63-16-14-51-34-5-1-4-32-39(34)46(62)55(45(32)61)35-11-13-37(57)52-44(35)60/h1,4-10,12,25,30,35,51H,2-3,11,13-24,26-27,49H2,(H2,50,59)(H,52,57,60)/t30-,35?/m1/s1","PDQGUWCWGITGBA-OSRRZMJMSA-N"
"219","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","1.1/37.4","87/80","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","61","SPR","","","","","","","","","","","","","","","3000","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","976.988","976.377840228","2.76","70","7","17","4","25","267.43","C47H54F2N8O13","InChI=1S/C47H54F2N8O13/c48-30-8-12-37(34(49)27-30)70-32-9-6-29(7-10-32)41-40(43(51)59)42(50)57(54-41)31-3-2-15-55(28-31)47(63)69-26-25-68-24-23-67-22-21-66-20-19-65-18-17-64-16-14-52-35-5-1-4-33-39(35)46(62)56(45(33)61)36-11-13-38(58)53-44(36)60/h1,4-10,12,27,31,36,52H,2-3,11,13-26,28,50H2,(H2,51,59)(H,53,58,60)/t31-,36?/m1/s1","XXNGOJVDXDGATG-RACIXVTASA-N"
"220","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)COCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","9.7/184.1","85/70","Degradation of BTK in Ramos/THP-1 cells after 24 h treatment","","","","","","","138","SPR","","","","","","","","","","","","","","","3100","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","991.015","990.393490292","2.24","71","7","17","4","27","267.43","C48H56F2N8O13","InChI=1S/C48H56F2N8O13/c49-31-8-12-38(35(50)27-31)71-33-9-6-30(7-10-33)43-42(45(52)61)44(51)58(55-43)32-3-2-15-56(28-32)40(60)29-70-26-25-69-24-23-68-22-21-67-20-19-66-18-17-65-16-14-53-36-5-1-4-34-41(36)48(64)57(47(34)63)37-11-13-39(59)54-46(37)62/h1,4-10,12,27,32,37,53H,2-3,11,13-26,28-29,51H2,(H2,52,61)(H,54,59,62)/t32-,37?/m1/s1","VRWPZJRZYSWRQV-ZIQZBVCVSA-N"
"221","Q06187","BTK","cIAP1","6W8I","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOCCOCCOCCOC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","1180.361","1179.58162541","6.23","85","8","16","5","27","262.39","C62H79F2N9O12","InChI=1S/C62H79F2N9O12/c1-39(67-5)58(75)69-55(62(2,3)4)60(77)72-37-43-34-47(21-17-42(43)35-51(72)59(76)68-50-14-8-11-40-10-6-7-13-48(40)50)83-32-30-81-28-26-79-24-25-80-27-29-82-31-33-84-61(78)71-23-9-12-45(38-71)73-56(65)53(57(66)74)54(70-73)41-15-19-46(20-16-41)85-52-22-18-44(63)36-49(52)64/h6-7,10,13,15-22,34,36,39,45,50-51,55,67H,8-9,11-12,14,23-33,35,37-38,65H2,1-5H3,(H2,66,74)(H,68,76)(H,69,75)/t39-,45+,50+,51-,55+/m0/s1","ZYNKGHHFEDYPKB-HQBWEIPVSA-N"
"221","Q06187","BTK","cIAP1","6W8I","BC5P","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOCCOCCOCCOC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","182","","Degradation of BTK in THP-1 cells","","","","","","","259","BLI","","","","","","","","","","","","","","","7","BLI in cIAP1 Bir3","","","","","","","","","","","","","","","474","BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00686-2","1180.361","1179.58162541","6.23","85","8","16","5","27","262.39","C62H79F2N9O12","InChI=1S/C62H79F2N9O12/c1-39(67-5)58(75)69-55(62(2,3)4)60(77)72-37-43-34-47(21-17-42(43)35-51(72)59(76)68-50-14-8-11-40-10-6-7-13-48(40)50)83-32-30-81-28-26-79-24-25-80-27-29-82-31-33-84-61(78)71-23-9-12-45(38-71)73-56(65)53(57(66)74)54(70-73)41-15-19-46(20-16-41)85-52-22-18-44(63)36-49(52)64/h6-7,10,13,15-22,34,36,39,45,50-51,55,67H,8-9,11-12,14,23-33,35,37-38,65H2,1-5H3,(H2,66,74)(H,68,76)(H,69,75)/t39-,45+,50+,51-,55+/m0/s1","ZYNKGHHFEDYPKB-HQBWEIPVSA-N"
"222","Q06187","BTK","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOCCOCCOCCOCCOC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","1224.414","1223.60784016","6.09","88","8","17","5","30","271.62","C64H83F2N9O13","InChI=1S/C64H83F2N9O13/c1-41(69-5)60(77)71-57(64(2,3)4)62(79)74-39-45-36-49(21-17-44(45)37-53(74)61(78)70-52-14-8-11-42-10-6-7-13-50(42)52)86-34-32-84-30-28-82-26-24-81-25-27-83-29-31-85-33-35-87-63(80)73-23-9-12-47(40-73)75-58(67)55(59(68)76)56(72-75)43-15-19-48(20-16-43)88-54-22-18-46(65)38-51(54)66/h6-7,10,13,15-22,36,38,41,47,52-53,57,69H,8-9,11-12,14,23-35,37,39-40,67H2,1-5H3,(H2,68,76)(H,70,78)(H,71,77)/t41-,47+,52+,53-,57+/m0/s1","BIDAQEXRCZPELN-FAZZRPLFSA-N"
"223","Q9UM73","ALK","CRBN","","MS4077","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","3/34","","Degradation of NPM-ALK/EML4-ALK in SU-DHL-1/NCI-H2228 cells after 16 h treatment","","","","","","","37","Kd was assessed by a competitive binding assay using DNA tag labeled ALK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","46","Inhibit proliferation of SU-DHL-1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2018.03.071","1134.751","1133.46588204","5.93","79","7","19","5","31","267.28","C55H72ClN9O13S","InChI=1S/C55H72ClN9O13S/c1-35(2)78-46-32-40(37(5)31-44(46)61-55-59-33-41(56)51(63-55)60-42-10-6-7-12-47(42)79(71,72)36(3)4)38-15-19-64(20-16-38)34-49(67)58-18-22-74-24-26-76-28-30-77-29-27-75-25-23-73-21-17-57-43-11-8-9-39-50(43)54(70)65(53(39)69)45-13-14-48(66)62-52(45)68/h6-12,31-33,35-36,38,45,57H,13-30,34H2,1-5H3,(H,58,67)(H,62,66,68)(H2,59,60,61,63)","VEKJQNCZEPLNJF-UHFFFAOYSA-N"
"224","Q9UM73","ALK","CRBN","","MS4078","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","11/59","","Degradation of NPM-ALK/EML4-ALK in SU-DHL-1/NCI-H2228 cells after 16 h treatment","","","","","","","19","Kd was assessed by a competitive binding assay using DNA tag labeled ALK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","33","Inhibit proliferation of SU-DHL-1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2018.03.071","914.486","913.334808304","6.66","64","7","14","5","16","221.13","C45H52ClN9O8S","InChI=1S/C45H52ClN9O8S/c1-25(2)63-36-22-30(27(5)21-34(36)51-45-49-23-31(46)41(53-45)50-32-10-6-7-12-37(32)64(61,62)26(3)4)28-15-19-54(20-16-28)24-39(57)48-18-17-47-33-11-8-9-29-40(33)44(60)55(43(29)59)35-13-14-38(56)52-42(35)58/h6-12,21-23,25-26,28,35,47H,13-20,24H2,1-5H3,(H,48,57)(H,52,56,58)(H2,49,50,51,53)","AYMGZLUKTNXEMY-UHFFFAOYSA-N"
"225","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCC(=O)N/N=C/C1=CC=C(OCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)NO","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2018.05.057","687.714","687.276509144","1.3","50","5","13","5","17","226.31","C33H37N9O8","InChI=1S/C33H37N9O8/c43-27-15-14-26(31(46)36-27)42-32(47)24-6-5-7-25(30(24)33(42)48)34-19-22-20-41(40-37-22)16-17-50-23-12-10-21(11-13-23)18-35-38-28(44)8-3-1-2-4-9-29(45)39-49/h5-7,10-13,18,20,26,34,49H,1-4,8-9,14-17,19H2,(H,38,44)(H,39,45)(H,36,43,46)/b35-18+","WINFCFUYVLGBPA-MWBNBJEGSA-N"
"226","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCC(=O)N/N=C/C1=CC=C(OCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)NO","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2018.05.057","731.767","731.302723892","1.15","53","5","14","5","20","235.54","C35H41N9O9","InChI=1S/C35H41N9O9/c45-29-15-14-28(33(48)38-29)44-34(49)26-6-5-7-27(32(26)35(44)50)36-21-24-22-43(42-39-24)16-17-52-18-19-53-25-12-10-23(11-13-25)20-37-40-30(46)8-3-1-2-4-9-31(47)41-51/h5-7,10-13,20,22,28,36,51H,1-4,8-9,14-19,21H2,(H,40,46)(H,41,47)(H,38,45,48)/b37-20+","MMWBKRBWGVZFBX-HASSKWOGSA-N"
"227","Q9UBN7","HDAC6","CRBN","","dHDAC6","O=C(CCCCCCC(=O)N/N=C/C1=CC=C(OCCOCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)NO","34","70.5","Degradation of HDAC6 in MCF-7 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2018.05.057","775.82","775.32893864","1.0","56","5","15","5","23","244.77","C37H45N9O10","InChI=1S/C37H45N9O10/c47-31-15-14-30(35(50)40-31)46-36(51)28-6-5-7-29(34(28)37(46)52)38-23-26-24-45(44-41-26)16-17-54-18-19-55-20-21-56-27-12-10-25(11-13-27)22-39-42-32(48)8-3-1-2-4-9-33(49)43-53/h5-7,10-13,22,24,30,38,53H,1-4,8-9,14-21,23H2,(H,42,48)(H,43,49)(H,40,47,50)/b39-22+","MHILTYZXXFOWJH-WVKHYPTHSA-N"
"227","Q9UBN7","HDAC6","CRBN","","dHDAC6","O=C(CCCCCCC(=O)N/N=C/C1=CC=C(OCCOCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)NO","9.12","84.07","Degradation of HDAC6 in MM1S cells after 6 h treatment","47.9/73.5","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","775.82","775.32893864","1.0","56","5","15","5","23","244.77","C37H45N9O10","InChI=1S/C37H45N9O10/c47-31-15-14-30(35(50)40-31)46-36(51)28-6-5-7-29(34(28)37(46)52)38-23-26-24-45(44-41-26)16-17-54-18-19-55-20-21-56-27-12-10-25(11-13-27)22-39-42-32(48)8-3-1-2-4-9-33(49)43-53/h5-7,10-13,22,24,30,38,53H,1-4,8-9,14-21,23H2,(H,42,48)(H,43,49)(H,40,47,50)/b39-22+","MHILTYZXXFOWJH-WVKHYPTHSA-N"
"228","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCC(=O)N/N=C/C1=CC=C(OCCOCCOCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1)NO","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2018.05.057","819.873","819.355153388","0.86","59","5","16","5","26","254.0","C39H49N9O11","InChI=1S/C39H49N9O11/c49-33-15-14-32(37(52)42-33)48-38(53)30-6-5-7-31(36(30)39(48)54)40-25-28-26-47(46-43-28)16-17-56-18-19-57-20-21-58-22-23-59-29-12-10-27(11-13-29)24-41-44-34(50)8-3-1-2-4-9-35(51)45-55/h5-7,10-13,24,26,32,40,55H,1-4,8-9,14-23,25H2,(H,44,50)(H,45,51)(H,42,49,52)/b41-24+","MXLOXSLUDNZWRS-JBZNKQRISA-N"
"229","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","10","","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","97","ITC in BRD2 BD1","","","-9.57","-13.7","4.2","ITC in BRD2 BD1","","","","","","","","","249","ITC","","","-9.01","-7.9","-1.1","ITC","","","","","","","","","64","Kd between VHL and the complex of protac and BRD2 BD1 was tested by ITC","","","-9.85","-9.17","-0.6","ITC between VHL and BRD2 BD1:PROTAC","","","","","","","316","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40-,42-,44+/m0/s1","MYXWOZYARUULQX-LWKHJFSZSA-N"
"229","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","10","","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","249","ITC","","","-9.01","-7.9","-1.1","ITC","","","","","","","","","","","","","","","","","","","","","","","316","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40-,42-,44+/m0/s1","MYXWOZYARUULQX-LWKHJFSZSA-N"
"229","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","1~3","","Degradation of BRD4 in HeLa cells after 24 h treatment","","","","","","","28","ITC in BRD4 BD2","","","-10.3","-10.4","0.1","ITC in BRD4 BD2","","","","","","","","","249","ITC","","","-9.01","-7.9","-1.1","ITC","","","","","","","","","26","Kd between VHL and the complex of protac and BRD4 BD2 was tested by ITC","","","-10.13","-10.9","-0.6","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","316","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40-,42-,44+/m0/s1","MYXWOZYARUULQX-LWKHJFSZSA-N"
"230","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","3000","","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","111","ITC in BRD2 BD1","","","-9.49","-14.1","4.9","ITC in BRD2 BD1","","","","","","","","","603","ITC","","","-8.49","-5","-3.7","ITC","","","","","","","","","500","Kd between VHL and the complex of protac and BRD2 BD1 was tested by ITC","","","-8.6","-5.1","-3.6","ITC between VHL and BRD2 BD1:PROTAC","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40+,42-,44+/m0/s1","MYXWOZYARUULQX-JHKZXAJTSA-N"
"230","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","3000","","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","603","ITC","","","-8.49","-5","-3.7","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40+,42-,44+/m0/s1","MYXWOZYARUULQX-JHKZXAJTSA-N"
"230","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3[C@H](F)[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","10-30","","Degradation of BRD4 in HeLa cells after 24 h treatment","","","","","","","32","ITC in BRD4 BD2","","","-10.3","-9.3","-0.9","ITC in BRD4 BD2","","","","","","","","","603","ITC","","","-8.49","-5","-3.7","ITC","","","","","","","","","42","Kd between VHL and the complex of protac and BRD4 BD2 was tested by ITC","","","-10.01","-7.75","-2.34","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b05807","1020.651","1019.36005775","5.02","70","7","15","4","20","211.49","C49H59ClFN9O8S2","InChI=1S/C49H59ClFN9O8S2/c1-27-29(3)70-48-39(27)41(32-12-14-34(50)15-13-32)55-35(45-58-57-30(4)60(45)48)22-37(62)52-16-17-66-18-19-67-20-21-68-25-38(63)56-44(49(5,6)7)47(65)59-24-36(61)40(51)42(59)46(64)53-23-31-8-10-33(11-9-31)43-28(2)54-26-69-43/h8-15,26,35-36,40,42,44,61H,16-25H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t35-,36-,40+,42-,44+/m0/s1","MYXWOZYARUULQX-JHKZXAJTSA-N"
"231","O60885","BRD4","CRBN","","TD-230","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)N=N3)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.023","783.359","782.287798536","6.91","55","7","13","3","14","178.15","C39H43ClN10O4S","InChI=1S/C39H43ClN10O4S/c1-22-23(2)55-39-33(22)35(25-13-15-26(40)16-14-25)43-29(36-47-45-24(3)49(36)39)21-32(52)42-20-9-7-5-4-6-8-19-41-27-11-10-12-28-34(27)38(54)50(48-46-28)30-17-18-31(51)44-37(30)53/h10-16,29-30,41H,4-9,17-21H2,1-3H3,(H,42,52)(H,44,51,53)/t29-,30?/m0/s1","XFIAUNZVFKETDZ-UFXYQILXSA-N"
"232","O60885","BRD4","CRBN","","TD-207","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)N=N3)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.023","787.303","786.246327648","4.1","55","7","15","3","14","196.61","C37H39ClN10O6S","InChI=1S/C37H39ClN10O6S/c1-20-21(2)55-37-31(20)33(23-7-9-24(38)10-8-23)41-27(34-45-43-22(3)47(34)37)19-30(50)40-14-16-54-18-17-53-15-13-39-25-5-4-6-26-32(25)36(52)48(46-44-26)28-11-12-29(49)42-35(28)51/h4-10,27-28,39H,11-19H2,1-3H3,(H,40,50)(H,42,49,51)/t27-,28?/m0/s1","HNSIMTVHHYWCEY-MBMZGMDYSA-N"
"233","O60885","BRD4","CRBN","","TD-188","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)N=N4)C=C1)N=C2C1=CC=C(Cl)C=C1","3.3","","Degradation of BRD4 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.023","879.4","878.272542396","5.63","62","8","16","3","16","205.84","C43H43ClN10O7S","InChI=1S/C43H43ClN10O7S/c1-24-25(2)62-43-37(24)39(27-7-9-28(44)10-8-27)47-33(40-51-49-26(3)53(40)43)23-36(56)46-29-11-13-30(14-12-29)61-22-21-60-20-19-59-18-17-45-31-5-4-6-32-38(31)42(58)54(52-50-32)34-15-16-35(55)48-41(34)57/h4-14,33-34,45H,15-23H2,1-3H3,(H,46,56)(H,48,55,57)/t33-,34?/m0/s1","VQRXXRRZSHERKG-CDRRMRQFSA-N"
"234","O60885","BRD4","CRBN","","TD-428","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=CC(OCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)N=N4)=C1)N=C2C1=CC=C(Cl)C=C1","0.32","","Degradation of BRD4 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.023","879.4","878.272542396","5.63","62","8","16","3","16","205.84","C43H43ClN10O7S","InChI=1S/C43H43ClN10O7S/c1-24-25(2)62-43-37(24)39(27-10-12-28(44)13-11-27)47-33(40-51-49-26(3)53(40)43)23-36(56)46-29-6-4-7-30(22-29)61-21-20-60-19-18-59-17-16-45-31-8-5-9-32-38(31)42(58)54(52-50-32)34-14-15-35(55)48-41(34)57/h4-13,22,33-34,45H,14-21,23H2,1-3H3,(H,46,56)(H,48,55,57)/t33-,34?/m0/s1","XEZUBGASURUNMF-CDRRMRQFSA-N"
"235","P15056","BRAF","CRBN","","","COC1=CC(OC)=C(/C=C/S(=O)(=O)CC2=CC=C(OC)C(NCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C(OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12800/23120/19250","Inhibit growth of MCF-7/MDA-MB-231/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2019.03.035","706.73","706.194478908","2.61","50","5","12","3","13","195.74","C34H34N4O11S","InChI=1S/C34H34N4O11S/c1-46-20-15-27(48-3)21(28(16-20)49-4)12-13-50(44,45)18-19-8-10-26(47-2)24(14-19)35-17-30(40)36-23-7-5-6-22-31(23)34(43)38(33(22)42)25-9-11-29(39)37-32(25)41/h5-8,10,12-16,25,35H,9,11,17-18H2,1-4H3,(H,36,40)(H,37,39,41)/b13-12+","VFGWMYQUQFTRPQ-OUKQBFOZSA-N"
"236","P15056","BRAF","CRBN","","","COC1=CC(OC)=C(/C=C/S(=O)(=O)CC2=CC=C(OC)C(NCC(=O)NCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C(OC)=C1","","","","71.7/81","% B-Raf degradation in MCF-7 cells after 24 h treatment at 5000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2700/21210/18700","Inhibit growth of MCF-7/MDA-MB-231/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2019.03.035","763.782","763.215942624","1.95","54","5","13","4","15","224.84","C36H37N5O12S","InChI=1S/C36H37N5O12S/c1-50-21-15-28(52-3)22(29(16-21)53-4)12-13-54(48,49)19-20-8-10-27(51-2)25(14-20)37-17-31(43)38-18-32(44)39-24-7-5-6-23-33(24)36(47)41(35(23)46)26-9-11-30(42)40-34(26)45/h5-8,10,12-16,26,37H,9,11,17-19H2,1-4H3,(H,38,43)(H,39,44)(H,40,42,45)/b13-12+","AMOFJSISJOOLNX-OUKQBFOZSA-N"
"237","P15056","BRAF","CRBN","","","COC1=CC(OC)=C(/C=C/S(=O)(=O)CC2=CC=C(OC)C(NC(=O)CCC(=O)NCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C(OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6140/36960/11910","Inhibit growth of MCF-7/MDA-MB-231/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2019.03.035","805.819","805.226507308","0.98","57","5","13","4","16","241.91","C38H39N5O13S","InChI=1S/C38H39N5O13S/c1-53-22-17-29(55-3)23(30(18-22)56-4)14-15-57(51,52)20-21-8-10-28(54-2)26(16-21)41-32(45)13-12-31(44)39-19-34(47)40-25-7-5-6-24-35(25)38(50)43(37(24)49)27-9-11-33(46)42-36(27)48/h5-8,10,14-18,27H,9,11-13,19-20H2,1-4H3,(H,39,44)(H,40,47)(H,41,45)(H,42,46,48)/b15-14+","LWNTYVAXJRSOOF-CCEZHUSRSA-N"
"238","P15056","BRAF","CRBN","","","COC1=CC(OC)=C(/C=C/S(=O)(=O)CC2=CC=C(OC)C(NC(=O)CCCC(=O)NCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C(OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","38090/46230/14580","Inhibit growth of MCF-7/MDA-MB-231/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2019.03.035","819.846","819.242157372","1.34","58","5","13","4","17","241.91","C39H41N5O13S","InChI=1S/C39H41N5O13S/c1-54-23-18-30(56-3)24(31(19-23)57-4)15-16-58(52,53)21-22-11-13-29(55-2)27(17-22)42-33(46)10-6-9-32(45)40-20-35(48)41-26-8-5-7-25-36(26)39(51)44(38(25)50)28-12-14-34(47)43-37(28)49/h5,7-8,11,13,15-19,28H,6,9-10,12,14,20-21H2,1-4H3,(H,40,45)(H,41,48)(H,42,46)(H,43,47,49)/b16-15+","RFCPRTVHBUICNT-FOCLMDBBSA-N"
"239","P11802","CDK4","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","74.6/47.8","Inhibition of CDK4-cyclin D1/CDK4-cyclin D3","","","","","","","","","","","","","","","2200","Inhibition of CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2018.11.006","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","P11802","CDK4","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","137","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","Q00534","CDK6","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","13.5/305.7","Inhibition of CDK6-cyclin D1/CDK6-cyclin D3","","","","","","","","","","","","","","","2200","Inhibition of CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2018.11.006","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","Q00534","CDK6","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","39","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","P30291","Wee1","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","P11802","CDK4","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O",">100","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","P11802","CDK4","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","126","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","20","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","Q00534","CDK6","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","14.3","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"239","Q00534","CDK6","CRBN","","CP-7","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","13","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","50","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","936.04","935.428987024","1.62","68","8","18","4","21","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-27-51-47(54-42(34)57(31-6-3-4-7-31)45(64)40(29)30(2)59)52-37-12-10-32(26-50-37)56-18-16-55(17-19-56)28-39(61)49-15-21-67-23-25-68-24-22-66-20-14-48-35-9-5-8-33-41(35)46(65)58(44(33)63)36-11-13-38(60)53-43(36)62/h5,8-10,12,26-27,31,36,48H,3-4,6-7,11,13-25,28H2,1-2H3,(H,49,61)(H,53,60,62)(H,50,51,52,54)","UTSBHEVQCONLCR-UHFFFAOYSA-N"
"240","Q00534","CDK6","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","8.7/228.7","Inhibition of CDK6-cyclin D1/CDK6-cyclin D3","","","","","","","","","","","","","","","2200","Inhibition of CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2018.11.006","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","Q00534","CDK6","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","37.7","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","O14874","BCKDK","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","P11802","CDK4","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","P30291","Wee1","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","Q15118","PDK1","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","Q15119","PDK2","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","Q15120","PDK3","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"240","Q8NI60","COQ8A","CRBN","","BSJ-03-123","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","937.024","936.413002612","1.05","68","8","18","3","21","245.82","C47H56N10O11","InChI=1S/C47H56N10O11/c1-29-34-27-50-47(53-42(34)56(31-6-3-4-7-31)45(63)40(29)30(2)58)51-37-12-10-32(26-49-37)55-17-15-54(16-18-55)19-21-66-23-25-67-24-22-65-20-14-48-39(60)28-68-36-9-5-8-33-41(36)46(64)57(44(33)62)35-11-13-38(59)52-43(35)61/h5,8-10,12,26-27,31,35H,3-4,6-7,11,13-25,28H2,1-2H3,(H,48,60)(H,52,59,61)(H,49,50,51,53)","LUHCYAOYQIFNRN-UHFFFAOYSA-N"
"241","Q06187","BTK","CRBN","","P10I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">200/>1000","Inhibit viability of HBL-1/RAMOS cells","","","","","","","","","","","10.1038/s41422-018-0055-1","868.912","868.340506368","2.81","64","9","17","3","16","243.91","C44H44N12O8","InChI=1S/C44H44N12O8/c45-39-37-38(27-11-13-30(14-12-27)64-29-7-2-1-3-8-29)51-56(40(37)48-26-47-39)28-6-5-18-53(24-28)43(60)33-25-54(52-50-33)19-21-63-23-22-62-20-17-46-32-10-4-9-31-36(32)44(61)55(42(31)59)34-15-16-35(57)49-41(34)58/h1-4,7-14,25-26,28,34,46H,5-6,15-24H2,(H2,45,47,48)(H,49,57,58)/t28-,34?/m1/s1","FTBBMMAHWSTFHQ-JSAORFSISA-N"
"242","Q06187","BTK C481S","CRBN","","P13I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28.8","Inhibit viability of HBL-1 cells expressing BTK C481S","","","","","","","","","","","10.1038/s41422-018-0055-1","912.965","912.366721116","2.67","67","9","18","3","19","253.14","C46H48N12O9","InChI=1S/C46H48N12O9/c47-41-39-40(29-11-13-32(14-12-29)67-31-7-2-1-3-8-31)53-58(42(39)50-28-49-41)30-6-5-18-55(26-30)45(62)35-27-56(54-52-35)19-21-65-23-25-66-24-22-64-20-17-48-34-10-4-9-33-38(34)46(63)57(44(33)61)36-15-16-37(59)51-43(36)60/h1-4,7-14,27-28,30,36,48H,5-6,15-26H2,(H2,47,49,50)(H,51,59,60)/t30-,36?/m1/s1","DAKOVCJVMZQQAH-XMGIQNEDSA-N"
"242","Q06187","BTK","CRBN","","P13I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","8.5/6.3/9.2/11.4","","Degradation of BTK in RAMOS/HBL-1/Mino/IgE MM cells after 48 h treatment","","","95","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.5/>1000","Inhibit viability of HBL-1/RAMOS cells","","","","","","","","","","","10.1038/s41422-018-0055-1","912.965","912.366721116","2.67","67","9","18","3","19","253.14","C46H48N12O9","InChI=1S/C46H48N12O9/c47-41-39-40(29-11-13-32(14-12-29)67-31-7-2-1-3-8-31)53-58(42(39)50-28-49-41)30-6-5-18-55(26-30)45(62)35-27-56(54-52-35)19-21-65-23-25-66-24-22-64-20-17-48-34-10-4-9-33-38(34)46(63)57(44(33)61)36-15-16-37(59)51-43(36)60/h1-4,7-14,27-28,30,36,48H,5-6,15-26H2,(H2,47,49,50)(H,51,59,60)/t30-,36?/m1/s1","DAKOVCJVMZQQAH-XMGIQNEDSA-N"
"243","Q06187","BTK","CRBN","","P16I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","71.1/>1000","Inhibit viability of HBL-1/RAMOS cells","","","","","","","","","","","10.1038/s41422-018-0055-1","957.018","956.392935864","2.52","70","9","19","3","22","262.37","C48H52N12O10","InChI=1S/C48H52N12O10/c49-43-41-42(31-11-13-34(14-12-31)70-33-7-2-1-3-8-33)55-60(44(41)52-30-51-43)32-6-5-18-57(28-32)47(64)37-29-58(56-54-37)19-21-67-23-25-69-27-26-68-24-22-66-20-17-50-36-10-4-9-35-40(36)48(65)59(46(35)63)38-15-16-39(61)53-45(38)62/h1-4,7-14,29-30,32,38,50H,5-6,15-28H2,(H2,49,51,52)(H,53,61,62)/t32-,38?/m1/s1","ZSAYALITESULSM-NMKCAVOUSA-N"
"244","Q06187","BTK","CRBN","","P13C-3","COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC=CC(NC(=O)CCCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)=C3)=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">200/>1000","Inhibit viability of HBL-1/RAMOS cells","","","","","","","","","","","10.1038/s41422-018-0055-1","893.934","893.362050336","3.18","65","7","17","5","24","242.15","C44H48FN11O9","InChI=1S/C44H48FN11O9/c1-62-21-24-65-32-13-11-28(12-14-32)50-44-47-26-34(45)40(52-44)49-30-6-2-5-29(25-30)48-37(57)10-3-7-31-27-55(54-53-31)18-20-64-23-22-63-19-17-46-35-9-4-8-33-39(35)43(61)56(42(33)60)36-15-16-38(58)51-41(36)59/h2,4-6,8-9,11-14,25-27,36,46H,3,7,10,15-24H2,1H3,(H,48,57)(H,51,58,59)(H2,47,49,50,52)","FOBXOXDPHSOQQY-UHFFFAOYSA-N"
"245","Q06187","BTK","CRBN","","P12I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN=NN2CCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","109.9","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","912.965","912.366721116","2.67","67","9","18","3","19","253.14","C46H48N12O9","InChI=1S/C46H48N12O9/c47-41-39-40(29-11-13-32(14-12-29)67-31-7-2-1-3-8-31)53-58(42(39)50-28-49-41)30-6-5-18-55(27-30)45(62)36-26-51-54-56(36)19-21-65-23-25-66-24-22-64-20-17-48-34-10-4-9-33-38(34)46(63)57(44(33)61)35-15-16-37(59)52-43(35)60/h1-4,7-14,26,28,30,35,48H,5-6,15-25,27H2,(H2,47,49,50)(H,52,59,60)/t30-,35?/m1/s1","STMFBMZTAVKRJL-OSRRZMJMSA-N"
"246","Q06187","BTK","CRBN","","P15I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN=NN2CCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","68.9","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","957.018","956.392935864","2.52","70","9","19","3","22","262.37","C48H52N12O10","InChI=1S/C48H52N12O10/c49-43-41-42(31-11-13-34(14-12-31)70-33-7-2-1-3-8-33)55-60(44(41)52-30-51-43)32-6-5-18-57(29-32)47(64)38-28-53-56-58(38)19-21-67-23-25-69-27-26-68-24-22-66-20-17-50-36-10-4-9-35-40(36)48(65)59(46(35)63)37-15-16-39(61)54-45(37)62/h1-4,7-14,28,30,32,37,50H,5-6,15-27,29H2,(H2,49,51,52)(H,54,61,62)/t32-,37?/m1/s1","HUNBRRVYOODLNY-ZIQZBVCVSA-N"
"247","Q06187","BTK","MDM2","","SM-4","COC1=CC=C(C2=N[C@H](C3=CC=C(Cl)C=C3)[C@H](C3=CC=C(Cl)C=C3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCN3C=C(CCCC(=O)N4CCC[C@@H](N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C6=C(N)N=CN=C65)C4)N=N3)C(=O)C2)C(OC(C)C)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">200","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","1276.297","1274.49837524","7.17","91","11","18","2","25","252.11","C66H72Cl2N14O9","InChI=1S/C66H72Cl2N14O9/c1-43(2)90-55-37-53(87-3)26-27-54(55)64-73-61(45-14-20-47(67)21-15-45)62(46-16-22-48(68)23-17-46)81(64)66(86)79-31-30-78(58(85)41-79)40-56(83)70-28-33-88-35-36-89-34-32-80-38-49(74-76-80)9-7-13-57(84)77-29-8-10-50(39-77)82-65-59(63(69)71-42-72-65)60(75-82)44-18-24-52(25-19-44)91-51-11-5-4-6-12-51/h4-6,11-12,14-27,37-38,42-43,50,61-62H,7-10,13,28-36,39-41H2,1-3H3,(H,70,83)(H2,69,71,72)/t50-,61-,62+/m1/s1","QVXYREUFOGGTJC-AZIWHTMZSA-N"
"248","Q06187","BTK","MDM2","","SM-8","COCCOC1=CC=C(NC2=NC=C(F)C(NC3=CC=CC(NC(=O)C4=CN(CCOCCOCCOCCNC(=O)CN5CCN(C(=O)N6C(C7=CC=C(OC)C=C7OC(C)C)=N[C@H](C7=CC=C(Cl)C=C7)[C@@H]6C6=CC=C(Cl)C=C6)CC5=O)N=N4)=C3)=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">200","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","1261.21","1259.45223358","6.8","89","9","19","4","30","259.58","C62H68Cl2FN13O11","InChI=1S/C62H68Cl2FN13O11/c1-40(2)89-53-35-49(84-4)20-21-50(53)59-71-56(41-8-12-43(63)13-9-41)57(42-10-14-44(64)15-11-42)78(59)62(82)76-24-23-75(55(80)39-76)38-54(79)66-22-26-85-29-31-87-32-30-86-27-25-77-37-52(73-74-77)60(81)69-47-7-5-6-46(34-47)68-58-51(65)36-67-61(72-58)70-45-16-18-48(19-17-45)88-33-28-83-3/h5-21,34-37,40,56-57H,22-33,38-39H2,1-4H3,(H,66,79)(H,69,81)(H2,67,68,70,72)/t56-,57+/m1/s1","BKAPUDNBNMGJHD-NQXWCLKQSA-N"
"249","Q06187","BTK","MDM2","","R10I","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C)(C2=CC=C(Cl)C=C2)C(C)(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCN2C=C(C(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C5=C(N)N=CN=C54)C3)N=N2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","138.7","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","1304.395","1302.56606088","8.89","93","11","18","2","24","235.04","C69H80Cl2N14O8","InChI=1S/C69H80Cl2N14O8/c1-7-92-58-42-50(67(2,3)4)21-28-56(58)63-76-68(5,48-17-22-51(70)23-18-48)69(6,49-19-24-52(71)25-20-49)84(63)66(88)81-33-31-80(32-34-81)45-59(86)73-29-36-89-38-40-91-41-39-90-37-35-83-44-57(77-79-83)65(87)82-30-11-12-53(43-82)85-64-60(62(72)74-46-75-64)61(78-85)47-15-26-55(27-16-47)93-54-13-9-8-10-14-54/h8-10,13-28,42,44,46,53H,7,11-12,29-41,43,45H2,1-6H3,(H,73,86)(H2,72,74,75)/t53-,68?,69?/m1/s1","GEIAMKLMBBZUDN-OPJPFPOJSA-N"
"250","Q06187","BTK","MDM2","","R13I","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C)(C2=CC=C(Cl)C=C2)C(C)(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCOCCN2C=C(C(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C5=C(N)N=CN=C54)C3)N=N2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","201.3","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","1348.448","1346.59227563","8.74","96","11","19","2","27","244.27","C71H84Cl2N14O9","InChI=1S/C71H84Cl2N14O9/c1-7-95-60-44-52(69(2,3)4)21-28-58(60)65-78-70(5,50-17-22-53(72)23-18-50)71(6,51-19-24-54(73)25-20-51)86(65)68(90)83-33-31-82(32-34-83)47-61(88)75-29-36-91-38-40-93-42-43-94-41-39-92-37-35-85-46-59(79-81-85)67(89)84-30-11-12-55(45-84)87-66-62(64(74)76-48-77-66)63(80-87)49-15-26-57(27-16-49)96-56-13-9-8-10-14-56/h8-10,13-28,44,46,48,55H,7,11-12,29-43,45,47H2,1-6H3,(H,75,88)(H2,74,76,77)/t55-,70?,71?/m1/s1","GNGQHZNNUNCGOZ-KBVIKDRVSA-N"
"251","Q06187","BTK","CRBN","","P13I-6","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCCCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">200","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","907.049","906.428927448","7.25","67","9","15","3","19","225.45","C49H54N12O6","InChI=1S/C49H54N12O6/c50-44-42-43(32-20-22-35(23-21-32)67-34-16-9-8-10-17-34)56-61(45(42)53-31-52-44)33-15-14-27-58(29-33)48(65)38-30-59(57-55-38)28-12-7-5-3-1-2-4-6-11-26-51-37-19-13-18-36-41(37)49(66)60(47(36)64)39-24-25-40(62)54-46(39)63/h8-10,13,16-23,30-31,33,39,51H,1-7,11-12,14-15,24-29H2,(H2,50,52,53)(H,54,62,63)/t33-,39?/m1/s1","CRJSNMLRSIZNBY-LXJLEQQOSA-N"
"252","Q06187","BTK","CRBN","","P10I-6","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCC2=CN(CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","82.2","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","864.968","864.381977256","4.47","64","9","15","3","16","225.45","C46H48N12O6","InChI=1S/C46H48N12O6/c47-42-40-41(29-17-19-33(20-18-29)64-32-12-3-1-4-13-32)53-58(43(40)50-28-49-42)31-11-9-24-55(27-31)38(60)16-7-10-30-26-56(54-52-30)25-6-2-5-23-48-35-15-8-14-34-39(35)46(63)57(45(34)62)36-21-22-37(59)51-44(36)61/h1,3-4,8,12-15,17-20,26,28,31,36,48H,2,5-7,9-11,16,21-25,27H2,(H2,47,49,50)(H,51,59,61)/t31-,36?/m1/s1","YDOWMXSUIBQUCU-RACIXVTASA-N"
"253","Q06187","BTK","CRBN","","P7I-2","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50-200","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","822.887","822.335027064","4.18","61","9","15","3","13","225.45","C43H42N12O6","InChI=1S/C43H42N12O6/c44-38-36-37(26-14-16-29(17-15-26)61-28-10-3-1-4-11-28)50-55(39(36)47-25-46-38)27-9-8-21-52(23-27)42(59)32-24-53(51-49-32)22-6-2-5-20-45-31-13-7-12-30-35(31)43(60)54(41(30)58)33-18-19-34(56)48-40(33)57/h1,3-4,7,10-17,24-25,27,33,45H,2,5-6,8-9,18-23H2,(H2,44,46,47)(H,48,56,57)/t27-,33?/m1/s1","QYSVOHFYDXKFAW-KOBZZRQBSA-N"
"254","Q06187","BTK","CRBN","","P6I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5-20","Inhibit viability of HBL-1 cells","","","","","","","","","","","10.1038/s41422-018-0055-1","783.89","783.34928016","5.5","58","8","12","3","14","194.74","C43H45N9O6","InChI=1S/C43H45N9O6/c44-39-37-38(27-17-19-30(20-18-27)58-29-12-5-4-6-13-29)49-52(40(37)47-26-46-39)28-11-10-24-50(25-28)35(54)16-7-2-1-3-8-23-45-32-15-9-14-31-36(32)43(57)51(42(31)56)33-21-22-34(53)48-41(33)55/h4-6,9,12-15,17-20,26,28,33,45H,1-3,7-8,10-11,16,21-25H2,(H2,44,46,47)(H,48,53,55)/t28-,33?/m1/s1","ZKOLOVUMLBKGOH-TUDONDPESA-N"
"255","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","47","Degradation of AR in VCaP cells after 20 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-018-0105-8","1008.155","1007.35330303","5.87","70","6","13","3","20","195.89","C49H56F3N7O9S2","InChI=1S/C49H56F3N7O9S2/c1-30-41(70-29-55-30)32-9-7-31(8-10-32)26-54-43(62)39-24-36(60)27-57(39)44(63)42(47(2,3)4)56-40(61)28-67-20-19-65-17-18-66-21-22-68-37-15-13-34(14-16-37)59-46(69)58(45(64)48(59,5)6)35-12-11-33(25-53)38(23-35)49(50,51)52/h7-16,23,29,36,39,42,60H,17-22,24,26-28H2,1-6H3,(H,54,62)(H,56,61)/t36-,39+,42-/m1/s1","HIWSGVNEQRFBBA-QLMCDVMBSA-N"
"256","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","15","76","Degradation of AR in VCaP cells after 20 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","0.35","Compounds were administered at 10000 nM and incubated for 2 h","0.24","Compounds were administered at 10000 nM and incubated for 2 h","10.1038/s42003-018-0105-8; 10.1021/acsmedchemlett.0c00194","1020.21","1019.38968854","7.45","71","6","12","3","21","186.66","C51H60F3N7O8S2","InChI=1S/C51H60F3N7O8S2/c1-32-43(71-31-57-32)34-13-11-33(12-14-34)28-56-45(64)41-26-38(62)29-59(41)46(65)44(49(2,3)4)58-42(63)30-68-23-10-22-67-21-8-7-9-24-69-39-19-17-36(18-20-39)61-48(70)60(47(66)50(61,5)6)37-16-15-35(27-55)40(25-37)51(52,53)54/h11-20,25,31,38,41,44,62H,7-10,21-24,26,28-30H2,1-6H3,(H,56,64)(H,58,63)/t38-,41+,44-/m1/s1","MTZBLTXMAXNSIO-UMWCMSNQSA-N"
"257","P10275","AR","VHL","","ARCC-4","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCOC3=CC=C(C4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","5","98","Degradation of AR in VCaP cells after 20 h treatment","","","36","Inhibition of AR by AR radioligand binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","150","Inhibit proliferation of VCaP cells","","","","","","","","","","","","","","","10.1038/s42003-018-0105-8","1024.201","1023.36347379","8.51","72","7","11","3","17","177.43","C53H56F3N7O7S2","InChI=1S/C53H56F3N7O7S2/c1-32-45(72-31-59-32)36-11-9-33(10-12-36)28-58-47(66)43-26-40(64)29-61(43)48(67)46(51(2,3)4)60-44(65)30-69-23-7-8-24-70-41-21-16-35(17-22-41)34-13-18-38(19-14-34)63-50(71)62(49(68)52(63,5)6)39-20-15-37(27-57)42(25-39)53(54,55)56/h9-22,25,31,40,43,46,64H,7-8,23-24,26,28-30H2,1-6H3,(H,58,66)(H,60,65)/t40-,43+,46-/m1/s1","DUPAJELXESPTNF-PPZGWQTASA-N"
"258","P41182","BCL6","CRBN","","","CN1C(=O)CCC2=CC3=CC(=C21)OCCOC[C@H]1CN(C(=O)CCC(=O)NCCCOCCOCCOC2=CC=CC4=C2C(=O)N(C2CCC(=O)NC2=O)C4=O)CCN1C1=NC=C(Cl)C(=N1)N3","","","","","","120","Inhibition of BCL6 by a TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000/1585/12589","Inhibit proliferation of OCI-Ly1/Karpas 422/SUDHL-4 cells","","","","","","","0.081","Compounds were administered at 5000 nM and incubated for 45 and 120 min","","","10.1021/acschembio.8b00698","946.415","945.342395784","0.54","67","8","16","3","15","240.47","C45H52ClN9O12","InChI=1S/C45H52ClN9O12/c1-52-37(58)10-6-27-22-28-23-34(40(27)52)67-21-19-65-26-29-25-53(13-14-54(29)45-48-24-31(46)41(49-28)51-45)38(59)11-9-35(56)47-12-3-15-63-16-17-64-18-20-66-33-5-2-4-30-39(33)44(62)55(43(30)61)32-7-8-36(57)50-42(32)60/h2,4-5,22-24,29,32H,3,6-21,25-26H2,1H3,(H,47,56)(H,48,49,51)(H,50,57,60)/t29-,32?/m1/s1","YQWUMLVLLIWGQJ-UYEDPJPISA-N"
"259","Q9UM73","ALK","VHL","","TD-004","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(C(=O)CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","110","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","180/58","Inhibit proliferation of H3122/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1084.807","1083.44772988","8.65","75","7","14","5","19","225.15","C55H70ClN9O8S2","InChI=1S/C55H70ClN9O8S2/c1-32(2)73-45-27-40(34(5)25-43(45)61-54-58-29-41(56)51(63-54)60-42-13-10-11-14-46(42)75(71,72)33(3)4)37-21-23-64(24-22-37)48(68)16-12-15-47(67)62-50(55(7,8)9)53(70)65-30-39(66)26-44(65)52(69)57-28-36-17-19-38(20-18-36)49-35(6)59-31-74-49/h10-11,13-14,17-20,25,27,29,31-33,37,39,44,50,66H,12,15-16,21-24,26,28,30H2,1-9H3,(H,57,69)(H,62,67)(H2,58,60,61,63)/t39-,44+,50-/m1/s1","DYEAAIMUSQBHPL-MLENZQCQSA-N"
"260","Q9UM73","ALK","VHL","","TD-016","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","140","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1112.861","1111.47903001","9.55","77","7","14","5","21","225.15","C57H74ClN9O8S2","InChI=1S/C57H74ClN9O8S2/c1-34(2)75-47-29-42(36(5)27-45(47)63-56-60-31-43(58)53(65-56)62-44-15-13-14-16-48(44)77(73,74)35(3)4)39-23-25-66(26-24-39)50(70)18-12-10-11-17-49(69)64-52(57(7,8)9)55(72)67-32-41(68)28-46(67)54(71)59-30-38-19-21-40(22-20-38)51-37(6)61-33-76-51/h13-16,19-22,27,29,31,33-35,39,41,46,52,68H,10-12,17-18,23-26,28,30,32H2,1-9H3,(H,59,71)(H,64,69)(H2,60,62,63,65)/t41-,46+,52-/m1/s1","ZZMFLQGXQVEFQJ-UBBOFEIVSA-N"
"261","Q9UM73","ALK","VHL","","TD-009","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","32","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1070.824","1069.46846532","9.62","74","7","14","5","20","208.08","C55H72ClN9O7S2","InChI=1S/C55H72ClN9O7S2/c1-33(2)72-46-28-41(35(5)26-44(46)61-54-58-30-42(56)51(63-54)60-43-14-10-11-15-47(43)74(70,71)34(3)4)38-21-24-64(25-22-38)23-13-12-16-48(67)62-50(55(7,8)9)53(69)65-31-40(66)27-45(65)52(68)57-29-37-17-19-39(20-18-37)49-36(6)59-32-73-49/h10-11,14-15,17-20,26,28,30,32-34,38,40,45,50,66H,12-13,16,21-25,27,29,31H2,1-9H3,(H,57,68)(H,62,67)(H2,58,60,61,63)/t40-,45+,50-/m1/s1","OHFQCKZQSKKIFD-SHPBXJAASA-N"
"262","Q9UM73","ALK","VHL","","TD-013","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","89","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1072.796","1071.44772988","8.85","74","7","15","5","20","217.31","C54H70ClN9O8S2","InChI=1S/C54H70ClN9O8S2/c1-32(2)72-45-26-40(34(5)24-43(45)60-53-57-28-41(55)50(62-53)59-42-12-10-11-13-46(42)74(69,70)33(3)4)37-18-20-63(21-19-37)22-23-71-30-47(66)61-49(54(7,8)9)52(68)64-29-39(65)25-44(64)51(67)56-27-36-14-16-38(17-15-36)48-35(6)58-31-73-48/h10-17,24,26,28,31-33,37,39,44,49,65H,18-23,25,27,29-30H2,1-9H3,(H,56,67)(H,61,66)(H2,57,59,60,62)/t39-,44+,49-/m1/s1","ZUUOBKIQGTWRTG-IHSWUNQZSA-N"
"263","Q9UM73","ALK","VHL","","TD-020","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","20","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1086.823","1085.46337994","9.21","75","7","15","5","21","217.31","C55H72ClN9O8S2","InChI=1S/C55H72ClN9O8S2/c1-33(2)73-46-27-41(35(5)25-44(46)61-54-58-29-42(56)51(63-54)60-43-13-10-11-14-47(43)75(70,71)34(3)4)38-19-22-64(23-20-38)21-12-24-72-31-48(67)62-50(55(7,8)9)53(69)65-30-40(66)26-45(65)52(68)57-28-37-15-17-39(18-16-37)49-36(6)59-32-74-49/h10-11,13-18,25,27,29,32-34,38,40,45,50,66H,12,19-24,26,28,30-31H2,1-9H3,(H,57,68)(H,62,67)(H2,58,60,61,63)/t40-,45+,50-/m1/s1","ZCZMPWIWTOAPBN-SHPBXJAASA-N"
"264","Q9UM73","ALK","VHL","","TD-002","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","16","Inhibition of ALK by a HTRF enzyme assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bbrc.2018.09.169","1160.902","1159.50015938","8.56","80","7","17","5","26","235.77","C58H78ClN9O10S2","InChI=1S/C58H78ClN9O10S2/c1-36(2)78-49-30-44(38(5)28-47(49)64-57-61-32-45(59)54(66-57)63-46-12-10-11-13-50(46)80(73,74)37(3)4)41-18-20-67(21-19-41)22-23-75-24-25-76-26-27-77-34-51(70)65-53(58(7,8)9)56(72)68-33-43(69)29-48(68)55(71)60-31-40-14-16-42(17-15-40)52-39(6)62-35-79-52/h10-17,28,30,32,35-37,41,43,48,53,69H,18-27,29,31,33-34H2,1-9H3,(H,60,71)(H,65,70)(H2,61,63,64,66)/t43-,48+,53-/m1/s1","ASCFRHUBIVTXOY-CXDQMHFXSA-N"
"265","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","23.2","99","Degradation of Fak in PC3 cells after 24 h treatment","","","10.7","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","982.121","981.348886348","5.86","68","6","14","5","19","217.31","C46H54F3N9O8S2","InChI=1S/C46H54F3N9O8S2/c1-28-39(67-27-53-28)31-12-10-29(11-13-31)22-51-42(61)37-21-34(59)25-58(37)43(62)40(45(2,3)4)55-38(60)26-65-18-19-66-35-16-14-32(15-17-35)54-44-52-24-36(46(47,48)49)41(56-44)50-23-30-8-7-9-33(20-30)57(5)68(6,63)64/h7-17,20,24,27,34,37,40,59H,18-19,21-23,25-26H2,1-6H3,(H,51,61)(H,55,60)(H2,50,52,54,56)/t34-,37+,40-/m1/s1","SSNVICBSSPQZQX-WPPCIPCFSA-N"
"266","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","7.6","99","Degradation of Fak in PC3 cells after 24 h treatment","","","14.7","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","996.148","995.364536412","6.22","69","6","14","5","20","217.31","C47H56F3N9O8S2","InChI=1S/C47H56F3N9O8S2/c1-29-40(68-28-54-29)32-13-11-30(12-14-32)23-52-43(62)38-22-35(60)26-59(38)44(63)41(46(2,3)4)56-39(61)27-66-19-8-20-67-36-17-15-33(16-18-36)55-45-53-25-37(47(48,49)50)42(57-45)51-24-31-9-7-10-34(21-31)58(5)69(6,64)65/h7,9-18,21,25,28,35,38,41,60H,8,19-20,22-24,26-27H2,1-6H3,(H,52,62)(H,56,61)(H2,51,53,55,57)/t35-,38+,41-/m1/s1","SHPXUUGJMCCMIO-LFHXYJAASA-N"
"267","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","3","99","Degradation of Fak in PC3 cells after 24 h treatment","","","6.5","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","996.148","995.364536412","5.76","69","6","14","5","20","217.31","C47H56F3N9O8S2","InChI=1S/C47H56F3N9O8S2/c1-29-40(68-28-54-29)32-12-10-30(11-13-32)24-52-43(62)38-23-35(60)27-59(38)44(63)41(46(2,3)4)56-39(61)18-19-66-20-21-67-36-16-14-33(15-17-36)55-45-53-26-37(47(48,49)50)42(57-45)51-25-31-8-7-9-34(22-31)58(5)69(6,64)65/h7-17,22,26,28,35,38,41,60H,18-21,23-25,27H2,1-6H3,(H,52,62)(H,56,61)(H2,51,53,55,57)/t35-,38+,41-/m1/s1","MVULIYLBRNHLEE-LFHXYJAASA-N"
"268","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","4","99","Degradation of Fak in PC3 cells after 24 h treatment","","","14.5","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","1010.175","1009.38018648","6.12","70","6","14","5","21","217.31","C48H58F3N9O8S2","InChI=1S/C48H58F3N9O8S2/c1-30-41(69-29-55-30)33-13-11-31(12-14-33)25-53-44(63)39-24-36(61)28-60(39)45(64)42(47(2,3)4)57-40(62)19-22-67-20-8-21-68-37-17-15-34(16-18-37)56-46-54-27-38(48(49,50)51)43(58-46)52-26-32-9-7-10-35(23-32)59(5)70(6,65)66/h7,9-18,23,27,29,36,39,42,61H,8,19-22,24-26,28H2,1-6H3,(H,53,63)(H,57,62)(H2,52,54,56,58)/t36-,39+,42-/m1/s1","WVWFJWJYLUTFRG-QLMCDVMBSA-N"
"269","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","20.8","99","Degradation of Fak in PC3 cells after 24 h treatment","","","12.7","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","1040.201","1039.39075116","5.62","72","6","15","5","23","226.54","C49H60F3N9O9S2","InChI=1S/C49H60F3N9O9S2/c1-31-42(71-30-56-31)34-12-10-32(11-13-34)26-54-45(64)40-25-37(62)29-61(40)46(65)43(48(2,3)4)58-41(63)18-19-68-20-21-69-22-23-70-38-16-14-35(15-17-38)57-47-55-28-39(49(50,51)52)44(59-47)53-27-33-8-7-9-36(24-33)60(5)72(6,66)67/h7-17,24,28,30,37,40,43,62H,18-23,25-27,29H2,1-6H3,(H,54,64)(H,58,63)(H2,53,55,57,59)/t37-,40+,43-/m1/s1","DRJLXMYTVYIROA-AKCINUCUSA-N"
"270","Q05397","FAK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOC3=CC=C(NC4=NC=C(C(F)(F)F)C(NCC5=CC=CC(N(C)S(C)(=O)=O)=C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","48.1","91","Degradation of Fak in PC3 cells after 24 h treatment","","","6.1","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","1128.307","1127.44318066","5.32","78","6","17","5","29","245.0","C53H68F3N9O11S2","InChI=1S/C53H68F3N9O11S2/c1-35-46(77-34-60-35)38-12-10-36(11-13-38)30-58-49(68)44-29-41(66)33-65(44)50(69)47(52(2,3)4)62-45(67)18-19-72-20-21-73-22-23-74-24-25-75-26-27-76-42-16-14-39(15-17-42)61-51-59-32-43(53(54,55)56)48(63-51)57-31-37-8-7-9-40(28-37)64(5)78(6,70)71/h7-17,28,32,34,41,44,47,66H,18-27,29-31,33H2,1-6H3,(H,58,68)(H,62,67)(H2,57,59,61,63)/t41-,44+,47-/m1/s1","CVMXJJVQILKJCT-IIWOMYBWSA-N"
"271","Q05397","FAK","CRBN","","","CN(C1=CC=CC(CNC2=NC(NC3=CC=C(OCCCOCCC(=O)NCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2C(F)(F)F)=C1)S(C)(=O)=O","8.2","98","Degradation of Fak in PC3 cells after 24 h treatment","","","11.3","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","896.902","896.277495236","3.22","63","6","14","4","20","227.56","C41H43F3N8O10S","InChI=1S/C41H43F3N8O10S/c1-51(63(2,58)59)27-7-3-6-25(22-27)23-46-36-30(41(42,43)44)24-47-40(50-36)48-26-10-12-28(13-11-26)61-19-5-18-60-20-16-33(53)45-17-21-62-32-9-4-8-29-35(32)39(57)52(38(29)56)31-14-15-34(54)49-37(31)55/h3-4,6-13,22,24,31H,5,14-21,23H2,1-2H3,(H,45,53)(H,49,54,55)(H2,46,47,48,50)","ATTMBNXPUWOYNQ-UHFFFAOYSA-N"
"272","Q05397","FAK","CRBN","","","CN(C1=CC=CC(CNC2=NC(NC3=CC=C(OCCOCCOCCC(=O)NCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2C(F)(F)F)=C1)S(C)(=O)=O","26.7","99","Degradation of Fak in PC3 cells after 24 h treatment","","","4.7","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","926.928","926.28805992","2.72","65","6","15","4","22","236.79","C42H45F3N8O11S","InChI=1S/C42H45F3N8O11S/c1-52(65(2,59)60)28-6-3-5-26(23-28)24-47-37-31(42(43,44)45)25-48-41(51-37)49-27-9-11-29(12-10-27)63-22-21-62-20-19-61-17-15-34(54)46-16-18-64-33-8-4-7-30-36(33)40(58)53(39(30)57)32-13-14-35(55)50-38(32)56/h3-12,23,25,32H,13-22,24H2,1-2H3,(H,46,54)(H,50,55,56)(H2,47,48,49,51)","RKQPBRYWQQLESB-UHFFFAOYSA-N"
"273","Q05397","FAK","CRBN","","","CN(C1=CC=CC(CNC2=NC(NC3=CC=C(OCCOCCOCCOCCOCCC(=O)NCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2C(F)(F)F)=C1)S(C)(=O)=O","<10","87","Degradation of Fak in PC3 cells after 24 h treatment","","","9.7","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.8b08008","1015.034","1014.34048942","2.42","71","6","17","4","28","255.25","C46H53F3N8O13S","InChI=1S/C46H53F3N8O13S/c1-56(71(2,63)64)32-6-3-5-30(27-32)28-51-41-35(46(47,48)49)29-52-45(55-41)53-31-9-11-33(12-10-31)69-26-25-68-24-23-67-22-21-66-20-19-65-17-15-38(58)50-16-18-70-37-8-4-7-34-40(37)44(62)57(43(34)61)36-13-14-39(59)54-42(36)60/h3-12,27,29,36H,13-26,28H2,1-2H3,(H,50,58)(H,54,59,60)(H2,51,52,53,55)","QZQNVCJSORWNHR-UHFFFAOYSA-N"
"274","P36888","FLT3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOC3=CC=C4C(=C3)SC3=NC(C5=CC=C(NC(=O)NC6=NOC(C(C)(C)C)=C6)C=C5)=CN34)C(C)(C)C)C=C2)SC=N1","","","","","","36","Inhibition of FLT-3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.6","Inhibit proliferation of MV4-11 cells","","","","","","","","","","","","","","","10.1021/jacs.8b10320","1020.248","1019.40336653","7.69","72","8","15","5","19","223.78","C52H61N9O9S2","InChI=1S/C52H61N9O9S2/c1-31-45(71-30-54-31)34-10-8-32(9-11-34)27-53-47(64)40-24-36(62)28-60(40)48(65)46(52(5,6)7)58-44(63)18-19-67-20-21-68-22-23-69-37-16-17-39-41(25-37)72-50-56-38(29-61(39)50)33-12-14-35(15-13-33)55-49(66)57-43-26-42(70-59-43)51(2,3)4/h8-17,25-26,29-30,36,40,46,62H,18-24,27-28H2,1-7H3,(H,53,64)(H,58,63)(H2,55,57,59,66)/t36-,40+,46-/m1/s1","IKJBYQODYFQASC-YKCITUTQSA-N"
"275","P04626","HER2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOC3=CC=C(C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(F)=C7)C(Cl)=C6)C5=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","102","Inhibit proliferation of SKBr3 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","1030.62","1029.36618868","9.03","73","8","13","4","21","186.36","C55H57ClFN7O8S","InChI=1S/C55H57ClFN7O8S/c1-34-50(73-33-61-34)38-10-8-35(9-11-38)28-58-53(67)47-27-42(65)29-64(47)54(68)51(55(2,3)4)63-49(66)31-70-21-20-69-22-23-71-43-16-12-37(13-17-43)39-14-18-46-44(25-39)52(60-32-59-46)62-41-15-19-48(45(56)26-41)72-30-36-6-5-7-40(57)24-36/h5-19,24-26,32-33,42,47,51,65H,20-23,27-31H2,1-4H3,(H,58,67)(H,63,66)(H,59,60,62)/t42-,47+,51-/m1/s1","ZSCOIFSUFMYZEZ-YSWDPXALSA-N"
"275","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOC3=CC=C(C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(F)=C7)C(Cl)=C6)C5=C4)C=C3)C(C)(C)C)C=C2)SC=N1","39.2/736.2","97.6/68.8","Degradation of WT/Exon 20 Ins EGFR in OVCAR8/HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","102","Inhibit proliferation of SKBr3 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","1030.62","1029.36618868","9.03","73","8","13","4","21","186.36","C55H57ClFN7O8S","InChI=1S/C55H57ClFN7O8S/c1-34-50(73-33-61-34)38-10-8-35(9-11-38)28-58-53(67)47-27-42(65)29-64(47)54(68)51(55(2,3)4)63-49(66)31-70-21-20-69-22-23-71-43-16-12-37(13-17-43)39-14-18-46-44(25-39)52(60-32-59-46)62-41-15-19-48(45(56)26-41)72-30-36-6-5-7-40(57)24-36/h5-19,24-26,32-33,42,47,51,65H,20-23,27-31H2,1-4H3,(H,58,67)(H,63,66)(H,59,60,62)/t42-,47+,51-/m1/s1","ZSCOIFSUFMYZEZ-YSWDPXALSA-N"
"276","P00533","EGFR","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","11.7/22.3","98.9/96.6","Degradation of Exon 19 del/L858R EGFR in HCC827/H3255 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","934.532","933.366188684","6.88","65","6","13","4","22","186.36","C47H57ClFN7O8S","InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64-40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33-,38+,43-/m1/s1","NICKHWYZMNLEPJ-TZSMONEZSA-N"
"277","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOC3=CC4=NC=NC(NC5=CC=C(F)C(Cl)=C5)=C4C=C3NC(=O)/C=C/CN(C)C)C(C)(C)C)C=C2)SC=N1","215.8","79.1","Degradation of L858R, T790M EGFR in H1975 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","1086.773","1085.4975372","7.81","76","6","14","5","29","209.47","C56H73ClFN9O8S","InChI=1S/C56H73ClFN9O8S/c1-37-51(76-36-62-37)39-19-17-38(18-20-39)33-59-54(71)47-30-41(68)34-67(47)55(72)52(56(2,3)4)65-50(70)15-8-7-9-24-73-25-10-11-26-74-27-12-13-28-75-48-32-45-42(31-46(48)64-49(69)16-14-23-66(5)6)53(61-35-60-45)63-40-21-22-44(58)43(57)29-40/h14,16-22,29,31-32,35-36,41,47,52,68H,7-13,15,23-28,30,33-34H2,1-6H3,(H,59,71)(H,64,69)(H,65,70)(H,60,61,63)/b16-14+/t41-,47+,52-/m1/s1","BXHBYEPLXDQKAT-JYCNGAFSSA-N"
"278","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC3=CC=C(C4=CC=C5N=CN=C(NC6=CC=C(OCC7=CC=CC(F)=C7)C(Cl)=C6)C5=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.009","1074.673","1073.39240343","8.88","76","8","14","4","24","195.59","C57H61ClFN7O9S","InChI=1S/C57H61ClFN7O9S/c1-36-52(76-35-63-36)40-10-8-37(9-11-40)30-60-55(69)49-29-44(67)31-66(49)56(70)53(57(2,3)4)65-51(68)33-73-23-22-71-20-21-72-24-25-74-45-16-12-39(13-17-45)41-14-18-48-46(27-41)54(62-34-61-48)64-43-15-19-50(47(58)28-43)75-32-38-6-5-7-42(59)26-38/h5-19,26-28,34-35,44,49,53,67H,20-25,29-33H2,1-4H3,(H,60,69)(H,65,68)(H,61,62,64)/t44-,49+,53-/m1/s1","XZNORRXEBCTXPB-KHBXAZQSSA-N"
"279","Q07820","MCL1","CRBN","","dMCL1-6","CC1=NN(C)C(COC2=CC=C(N3CCN(C(=O)CCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=C1C1=CC=CC2=C1N(CCN1CCOCC1)C(C(=O)O)=C2CCCOC1=CC=CC2=CC=CC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00455","1142.28","1141.49091858","3.45","84","11","16","3","22","236.41","C63H67N9O12","InChI=1S/C63H67N9O12/c1-40-56(47-14-6-13-45-46(16-9-35-82-51-17-5-11-41-10-3-4-12-44(41)51)59(63(79)80)71(58(45)47)32-27-68-33-36-81-37-34-68)50(67(2)66-40)38-83-43-22-20-42(21-23-43)69-28-30-70(31-29-69)55(75)19-8-26-64-54(74)39-84-52-18-7-15-48-57(52)62(78)72(61(48)77)49-24-25-53(73)65-60(49)76/h3-7,10-15,17-18,20-23,49H,8-9,16,19,24-39H2,1-2H3,(H,64,74)(H,79,80)(H,65,73,76)","JZQOTODZTIWWFI-UHFFFAOYSA-N"
"280","Q06187","BTK","CRBN","","MT-540","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCCCCCOCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","80.6","96","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","843.942","843.370409528","4.31","62","8","14","3","18","213.2","C45H49N9O8","InChI=1S/C45H49N9O8/c46-41-39-40(29-13-15-32(16-14-29)62-31-9-4-3-5-10-31)51-54(42(39)48-28-47-41)30-19-22-52(23-20-30)21-6-1-2-7-24-60-25-26-61-27-37(56)49-34-12-8-11-33-38(34)45(59)53(44(33)58)35-17-18-36(55)50-43(35)57/h3-5,8-16,28,30,35H,1-2,6-7,17-27H2,(H,49,56)(H2,46,47,48)(H,50,55,57)","YFWKTWXPNMNMSC-UHFFFAOYSA-N"
"281","Q06187","BTK","CRBN","","MT-541","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCCCOCCCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","90.1","93","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","843.942","843.370409528","4.31","62","8","14","3","18","213.2","C45H49N9O8","InChI=1S/C45H49N9O8/c46-41-39-40(29-13-15-32(16-14-29)62-31-9-2-1-3-10-31)51-54(42(39)48-28-47-41)30-19-22-52(23-20-30)21-4-5-24-60-25-6-7-26-61-27-37(56)49-34-12-8-11-33-38(34)45(59)53(44(33)58)35-17-18-36(55)50-43(35)57/h1-3,8-16,28,30,35H,4-7,17-27H2,(H,49,56)(H2,46,47,48)(H,50,55,57)","JJEBSGCXKQODDX-UHFFFAOYSA-N"
"282","Q06187","BTK","CRBN","","MT-781","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCCOCCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","68.3","95","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","829.915","829.354759464","3.5","61","8","14","3","17","213.2","C44H47N9O8","InChI=1S/C44H47N9O8/c45-40-38-39(28-11-13-31(14-12-28)61-30-7-2-1-3-8-30)50-53(41(38)47-27-46-40)29-17-21-51(22-18-29)20-5-23-59-24-6-25-60-26-19-36(55)48-33-10-4-9-32-37(33)44(58)52(43(32)57)34-15-16-35(54)49-42(34)56/h1-4,7-14,27,29,34H,5-6,15-26H2,(H,48,55)(H2,45,46,47)(H,49,54,56)","CESHFJRNQNNGLW-UHFFFAOYSA-N"
"283","Q06187","BTK","CRBN","","MT-802","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCC(=O)NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","6.2","99","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","787.834","787.307809272","2.33","58","8","14","3","14","213.2","C41H41N9O8","InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)","AJTLGUJXIKEZCQ-UHFFFAOYSA-N"
"283","Q06187","BTK","CRBN","","MT-802","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCC(=O)NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","9.1/14.6",">99/(n/a)","Degradation of BTK in NAMALWA/XLA cells after 24 h treatment","","","46.9","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","787.834","787.307809272","2.33","58","8","14","3","14","213.2","C41H41N9O8","InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)","AJTLGUJXIKEZCQ-UHFFFAOYSA-N"
"283","Q06187","BTK C481S","CRBN","","MT-802","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCC(=O)NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","14.9",">99","Degradation of C481S BTK in XLA cells after 24 h treatment","","","20.9","Inhibition of C481S BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","787.834","787.307809272","2.33","58","8","14","3","14","213.2","C41H41N9O8","InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)","AJTLGUJXIKEZCQ-UHFFFAOYSA-N"
"284","Q06187","BTK","CRBN","","MT-809","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCCCOCCCCOCC(=O)NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","11.6",">99","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","843.942","843.370409528","3.76","62","8","14","3","18","213.2","C45H49N9O8","InChI=1S/C45H49N9O8/c46-41-39-40(29-10-13-33(14-11-29)62-32-8-2-1-3-9-32)51-54(42(39)48-28-47-41)31-18-21-52(22-19-31)20-4-5-23-60-24-6-7-25-61-27-38(56)49-30-12-15-34-35(26-30)45(59)53(44(34)58)36-16-17-37(55)50-43(36)57/h1-3,8-15,26,28,31,36H,4-7,16-25,27H2,(H,49,56)(H2,46,47,48)(H,50,55,57)","VPGHQPSPNUQPLG-UHFFFAOYSA-N"
"285","P08581","c-Met","CRBN","","SJF-8242","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","100","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","992.986","992.3403921","5.03","72","8","14","4","24","239.12","C51H50F2N6O13","InChI=1S/C51H50F2N6O13/c1-67-41-28-34-36(54-19-15-38(34)72-39-13-11-32(27-35(39)53)57-50(66)51(17-18-51)49(65)56-31-9-7-30(52)8-10-31)29-42(41)70-24-4-23-68-21-3-22-69-25-16-43(60)55-20-26-71-40-6-2-5-33-45(40)48(64)59(47(33)63)37-12-14-44(61)58-46(37)62/h2,5-11,13,15,19,27-29,37H,3-4,12,14,16-18,20-26H2,1H3,(H,55,60)(H,56,65)(H,57,66)(H,58,61,62)","ZAJXSUNUSHEGCB-UHFFFAOYSA-N"
"285","O43353","RIPK2","CRBN","","SJF-8242","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","200","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","992.986","992.3403921","5.03","72","8","14","4","24","239.12","C51H50F2N6O13","InChI=1S/C51H50F2N6O13/c1-67-41-28-34-36(54-19-15-38(34)72-39-13-11-32(27-35(39)53)57-50(66)51(17-18-51)49(65)56-31-9-7-30(52)8-10-31)29-42(41)70-24-4-23-68-21-3-22-69-25-16-43(60)55-20-26-71-40-6-2-5-33-45(40)48(64)59(47(33)63)37-12-14-44(61)58-46(37)62/h2,5-11,13,15,19,27-29,37H,3-4,12,14,16-18,20-26H2,1H3,(H,55,60)(H,56,65)(H,57,66)(H,58,61,62)","ZAJXSUNUSHEGCB-UHFFFAOYSA-N"
"285","Q12866","MerTK","CRBN","","SJF-8242","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","7.8","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","992.986","992.3403921","5.03","72","8","14","4","24","239.12","C51H50F2N6O13","InChI=1S/C51H50F2N6O13/c1-67-41-28-34-36(54-19-15-38(34)72-39-13-11-32(27-35(39)53)57-50(66)51(17-18-51)49(65)56-31-9-7-30(52)8-10-31)29-42(41)70-24-4-23-68-21-3-22-69-25-16-43(60)55-20-26-71-40-6-2-5-33-45(40)48(64)59(47(33)63)37-12-14-44(61)58-46(37)62/h2,5-11,13,15,19,27-29,37H,3-4,12,14,16-18,20-26H2,1H3,(H,55,60)(H,56,65)(H,57,66)(H,58,61,62)","ZAJXSUNUSHEGCB-UHFFFAOYSA-N"
"285","O15264","p38delta","CRBN","","SJF-8242","COC1=CC2=C(OC3=CC=C(NC(=O)C4(C(=O)NC5=CC=C(F)C=C5)CC4)C=C3F)C=CN=C2C=C1OCCCOCCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","27","91","Degradation of p38delta in MDA-MB-231 cells after 24 h treatment","","","","","","","2000","Kd was assessed by competition binding assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2017.09.010","992.986","992.3403921","5.03","72","8","14","4","24","239.12","C51H50F2N6O13","InChI=1S/C51H50F2N6O13/c1-67-41-28-34-36(54-19-15-38(34)72-39-13-11-32(27-35(39)53)57-50(66)51(17-18-51)49(65)56-31-9-7-30(52)8-10-31)29-42(41)70-24-4-23-68-21-3-22-69-25-16-43(60)55-20-26-71-40-6-2-5-33-45(40)48(64)59(47(33)63)37-12-14-44(61)58-46(37)62/h2,5-11,13,15,19,27-29,37H,3-4,12,14,16-18,20-26H2,1H3,(H,55,60)(H,56,65)(H,57,66)(H,58,61,62)","ZAJXSUNUSHEGCB-UHFFFAOYSA-N"
"286","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCOC4=C(O)C=C(O)C5=C4OC(C4=CC=CC=C4)=CC5=O)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","639.617","639.185294128","3.62","47","6","10","4","10","192.55","C34H29N3O10","InChI=1S/C34H29N3O10/c38-22-16-24(40)30(31-29(22)23(39)17-25(47-31)18-8-3-1-4-9-18)46-15-6-2-5-12-26(41)35-20-11-7-10-19-28(20)34(45)37(33(19)44)21-13-14-27(42)36-32(21)43/h1,3-4,7-11,16-17,21,38,40H,2,5-6,12-15H2,(H,35,41)(H,36,42,43)","HDVCICGKYBZTPI-UHFFFAOYSA-N"
"287","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCOC4=C(O)C=C(O)C5=C4OC(C4=CC=CC=C4)=CC5=O)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","90000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","653.644","653.200944192","4.17","48","6","10","4","11","192.55","C35H31N3O10","InChI=1S/C35H31N3O10/c39-23-17-25(41)31(32-30(23)24(40)18-26(48-32)19-9-4-3-5-10-19)47-16-7-2-1-6-13-27(42)36-21-12-8-11-20-29(21)35(46)38(34(20)45)22-14-15-28(43)37-33(22)44/h3-5,8-12,17-18,22,39,41H,1-2,6-7,13-16H2,(H,36,42)(H,37,43,44)","QKDGWLYPBZZZQW-UHFFFAOYSA-N"
"288","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCCOC4=C(O)C=C(O)C5=C4OC(C4=CC=CC=C4)=CC5=O)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","667.671","667.216594256","4.71","49","6","10","4","12","192.55","C36H33N3O10","InChI=1S/C36H33N3O10/c40-24-18-26(42)32(33-31(24)25(41)19-27(49-33)20-10-5-4-6-11-20)48-17-8-3-1-2-7-14-28(43)37-22-13-9-12-21-30(22)36(47)39(35(21)46)23-15-16-29(44)38-34(23)45/h4-6,9-13,18-19,23,40,42H,1-3,7-8,14-17H2,(H,37,43)(H,38,44,45)","HKLSKKDDJXBUNV-UHFFFAOYSA-N"
"289","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCCCCOC4=C(O)C=C(O)C5=C4OC(C4=CC=CC=C4)=CC5=O)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","40000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","695.725","695.247894384","5.79","51","6","10","4","14","192.55","C38H37N3O10","InChI=1S/C38H37N3O10/c42-26-20-28(44)34(35-33(26)27(43)21-29(51-35)22-12-7-6-8-13-22)50-19-10-5-3-1-2-4-9-16-30(45)39-24-15-11-14-23-32(24)38(49)41(37(23)48)25-17-18-31(46)40-36(25)47/h6-8,11-15,20-21,25,42,44H,1-5,9-10,16-19H2,(H,39,45)(H,40,46,47)","RTIGEAUUEBAAJN-UHFFFAOYSA-N"
"290","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCN4C=C(COC5=C(O)C=C(O)C6=C5OC(C5=CC=CC=C5)=CC6=O)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","720.695","720.217991224","2.85","53","7","13","4","12","223.26","C37H32N6O10","InChI=1S/C37H32N6O10/c44-25-16-27(46)33(34-32(25)26(45)17-28(53-34)20-8-3-1-4-9-20)52-19-21-18-42(41-40-21)15-6-2-5-12-29(47)38-23-11-7-10-22-31(23)37(51)43(36(22)50)24-13-14-30(48)39-35(24)49/h1,3-4,7-11,16-18,24,44,46H,2,5-6,12-15,19H2,(H,38,47)(H,39,48,49)","FZWCKJRHXYMBSF-UHFFFAOYSA-N"
"291","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCN4C=C(COC5=C(O)C=C(O)C6=C5OC(C5=CC=CC=C5)=CC6=O)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","734.722","734.233641288","3.4","54","7","13","4","13","223.26","C38H34N6O10","InChI=1S/C38H34N6O10/c45-26-17-28(47)34(35-33(26)27(46)18-29(54-35)21-9-4-3-5-10-21)53-20-22-19-43(42-41-22)16-7-2-1-6-13-30(48)39-24-12-8-11-23-32(24)38(52)44(37(23)51)25-14-15-31(49)40-36(25)50/h3-5,8-12,17-19,25,45,47H,1-2,6-7,13-16,20H2,(H,39,48)(H,40,49,50)","SJFWOYMINLKTLS-UHFFFAOYSA-N"
"292","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCCN4C=C(COC5=C(O)C=C(O)C6=C5OC(C5=CC=CC=C5)=CC6=O)N=N4)=C3C2=O)C(=O)N1","","","","","","523","Inhibition of CDK9/CycT1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","748.749","748.249291352","3.94","55","7","13","4","14","223.26","C39H36N6O10","InChI=1S/C39H36N6O10/c46-27-18-29(48)35(36-34(27)28(47)19-30(55-36)22-10-5-4-6-11-22)54-21-23-20-44(43-42-23)17-8-3-1-2-7-14-31(49)40-25-13-9-12-24-33(25)39(53)45(38(24)52)26-15-16-32(50)41-37(26)51/h4-6,9-13,18-20,26,46,48H,1-3,7-8,14-17,21H2,(H,40,49)(H,41,50,51)","MRRHEHIWXXJQQL-UHFFFAOYSA-N"
"293","P50750","CDK9","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCCCCCN4C=C(COC5=C(O)C=C(O)C6=C5OC(C5=CC=CC=C5)=CC6=O)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","38000","Inhibit proliferation of MCF-7 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2018.08.028","776.803","776.28059148","5.02","57","7","13","4","16","223.26","C41H40N6O10","InChI=1S/C41H40N6O10/c48-29-20-31(50)37(38-36(29)30(49)21-32(57-38)24-12-7-6-8-13-24)56-23-25-22-46(45-44-25)19-10-5-3-1-2-4-9-16-33(51)42-27-15-11-14-26-35(27)41(55)47(40(26)54)28-17-18-34(52)43-39(28)53/h6-8,11-15,20-22,28,48,50H,1-5,9-10,16-19,23H2,(H,42,51)(H,43,52,53)","RPJHSUXZGNHSPJ-UHFFFAOYSA-N"
"294","Q92830","GCN5","CRBN","","GSK699","CN1C[C@H](NC2=C(Br)C(=O)N(C)N=C2)C[C@H](C2=CC=C(C(=O)N(C)CCCN(C)C3=CC=C(CCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)C=C2)C1","<3","","Degradation of GCN5 in THP1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.8b00705","895.856","894.306408072","4.67","61","7","12","2","15","166.49","C45H51BrN8O7","InChI=1S/C45H51BrN8O7/c1-50-26-31(24-32(27-50)48-35-25-47-53(4)45(60)40(35)46)29-13-15-30(16-14-29)42(57)52(3)22-7-21-51(2)33-17-11-28(12-18-33)8-6-23-61-37-10-5-9-34-39(37)44(59)54(43(34)58)36-19-20-38(55)49-41(36)56/h5,9-18,25,31-32,36,48H,6-8,19-24,26-27H2,1-4H3,(H,49,55,56)/t31-,32+,36?/m0/s1","SARLMRHJAJBYBI-CIDUPMPKSA-N"
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"308","P42336","PI3Kalpha","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCN4C=C(CN5CCN(C6=NC(N7CCOCC7)=NC(N7C(C(F)F)=NC8=CC=CC=C87)=N6)CC5)N=N4)=C3C2=O)C(=O)N1","","","","","","90","Inhibition of PI3Kalpha by Kinase-Glo Luminescent Kinase Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2018.03.066","838.837","838.32233144","1.64","61","9","17","2","12","218.8","C39H40F2N14O6","InChI=1S/C39H40F2N14O6/c40-32(41)33-43-25-6-1-2-8-27(25)54(33)39-46-37(45-38(47-39)52-17-19-61-20-18-52)51-15-13-50(14-16-51)21-23-22-53(49-48-23)12-4-9-29(56)42-26-7-3-5-24-31(26)36(60)55(35(24)59)28-10-11-30(57)44-34(28)58/h1-3,5-8,22,28,32H,4,9-21H2,(H,42,56)(H,44,57,58)","HUOBKLASHKHDNO-UHFFFAOYSA-N"
"309","P42336","PI3Kalpha","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCCN4C=C(CN5CCN(C6=NC(N7CCOCC7)=NC(N7C(C(F)F)=NC8=CC=CC=C87)=N6)CC5)N=N4)=C3C2=O)C(=O)N1","","","","","","86","Inhibition of PI3Kalpha by Kinase-Glo Luminescent Kinase Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2018.03.066","866.891","866.353631568","2.35","63","9","17","2","14","218.8","C41H44F2N14O6","InChI=1S/C41H44F2N14O6/c42-34(43)35-45-27-8-3-4-10-29(27)56(35)41-48-39(47-40(49-41)54-19-21-63-22-20-54)53-17-15-52(16-18-53)23-25-24-55(51-50-25)14-5-1-2-11-31(58)44-28-9-6-7-26-33(28)38(62)57(37(26)61)30-12-13-32(59)46-36(30)60/h3-4,6-10,24,30,34H,1-2,5,11-23H2,(H,44,58)(H,46,59,60)","SIFHOQAJZBNJLQ-UHFFFAOYSA-N"
"310","O60885","BRD4","VHL","","AT1","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","75/44","ITC in BRD4 BD1/2","","","-9.8/-10.2","-18.4/-9.8","8.7/0","ITC in BRD4 BD1/2","","","","","","","","","335","ITC","","","-8.85","-6.7","-2.2","ITC","","","","","","","","","390/46","Kd between VHL and AT1-BRD4 BD1/BD2 was tested by ITC","","","-8.8/-11.01","-2.2/-6.9","-6.57/-3.1","ITC between VHL and AT1-BRD4 BD1/BD2","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","972.704","971.341156636","6.35","66","7","13","4","18","183.8","C48H58ClN9O5S3","InChI=1S/C48H58ClN9O5S3/c1-27-29(3)66-47-40(27)41(33-16-18-35(49)19-17-33)54-37(44-56-55-30(4)58(44)47)23-39(61)50-20-10-8-9-11-21-65-48(6,7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-12-14-34(15-13-32)42-28(2)52-26-64-42/h12-19,26,36-38,43,60H,8-11,20-25H2,1-7H3,(H,50,61)(H,51,62)(H,53,59)/t36-,37+,38+,43+/m1/s1","SQNZDYHMCMIGGV-GMEZEQRCSA-N"
"310","O60885","BRD4","VHL","","AT1","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","110","SPR","","","","","","","600000","0.06","17","SPR","","","","","578/24","Kd between VHL and AT1-BRD4 BD1/2 was tested by SPR","","","","","","","1.6E+6/1.4E+6","0.9/0.03","0.8/26","SPR between VHL and AT1-BRD4 BD1/2","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","972.704","971.341156636","6.35","66","7","13","4","18","183.8","C48H58ClN9O5S3","InChI=1S/C48H58ClN9O5S3/c1-27-29(3)66-47-40(27)41(33-16-18-35(49)19-17-33)54-37(44-56-55-30(4)58(44)47)23-39(61)50-20-10-8-9-11-21-65-48(6,7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-12-14-34(15-13-32)42-28(2)52-26-64-42/h12-19,26,36-38,43,60H,8-11,20-25H2,1-7H3,(H,50,61)(H,51,62)(H,53,59)/t36-,37+,38+,43+/m1/s1","SQNZDYHMCMIGGV-GMEZEQRCSA-N"
"311","O60885","BRD4","VHL","","AT2","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","944.65","943.309856508","5.63","64","7","13","4","16","183.8","C46H54ClN9O5S3","InChI=1S/C46H54ClN9O5S3/c1-25-27(3)64-45-38(25)39(31-14-16-33(47)17-15-31)52-35(42-54-53-28(4)56(42)45)21-37(59)48-18-8-9-19-63-46(6,7)41(51-29(5)57)44(61)55-23-34(58)20-36(55)43(60)49-22-30-10-12-32(13-11-30)40-26(2)50-24-62-40/h10-17,24,34-36,41,58H,8-9,18-23H2,1-7H3,(H,48,59)(H,49,60)(H,51,57)/t34-,35+,36+,41+/m1/s1","IOMSZXFNEZLDNX-SGRXEVKCSA-N"
"312","O60885","BRD4","VHL","","AT3","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCOCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","960.649","959.304771128","4.77","65","7","14","4","17","193.03","C46H54ClN9O6S3","InChI=1S/C46H54ClN9O6S3/c1-25-27(3)65-45-38(25)39(31-12-14-33(47)15-13-31)52-35(42-54-53-28(4)56(42)45)21-37(59)48-16-17-62-18-19-64-46(6,7)41(51-29(5)57)44(61)55-23-34(58)20-36(55)43(60)49-22-30-8-10-32(11-9-30)40-26(2)50-24-63-40/h8-15,24,34-36,41,58H,16-23H2,1-7H3,(H,48,59)(H,49,60)(H,51,57)/t34-,35+,36+,41+/m1/s1","PGLFKKMUHZKAIR-SGRXEVKCSA-N"
"313","O60885","BRD4","VHL","","AT4","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCCOCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","988.703","987.336071256","5.48","67","7","14","4","19","193.03","C48H58ClN9O6S3","InChI=1S/C48H58ClN9O6S3/c1-27-29(3)67-47-40(27)41(33-14-16-35(49)17-15-33)54-37(44-56-55-30(4)58(44)47)23-39(61)50-18-8-19-64-20-9-21-66-48(6,7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-10-12-34(13-11-32)42-28(2)52-26-65-42/h10-17,26,36-38,43,60H,8-9,18-25H2,1-7H3,(H,50,61)(H,51,62)(H,53,59)/t36-,37+,38+,43+/m1/s1","HEOGZNNXKOEXLA-GMEZEQRCSA-N"
"314","O60885","BRD4","VHL","","AT5","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCCCOCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","988.703","987.336071256","5.48","67","7","14","4","19","193.03","C48H58ClN9O6S3","InChI=1S/C48H58ClN9O6S3/c1-27-29(3)67-47-40(27)41(33-14-16-35(49)17-15-33)54-37(44-56-55-30(4)58(44)47)23-39(61)50-18-20-64-19-8-9-21-66-48(6,7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-10-12-34(13-11-32)42-28(2)52-26-65-42/h10-17,26,36-38,43,60H,8-9,18-25H2,1-7H3,(H,50,61)(H,51,62)(H,53,59)/t36-,37+,38+,43+/m1/s1","JEAMBUIASSKROT-GMEZEQRCSA-N"
"315","O60885","BRD4","VHL","","AT6","CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)SCCOCCOCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","1004.702","1003.33098588","4.62","68","7","15","4","20","202.26","C48H58ClN9O7S3","InChI=1S/C48H58ClN9O7S3/c1-27-29(3)68-47-40(27)41(33-12-14-35(49)15-13-33)54-37(44-56-55-30(4)58(44)47)23-39(61)50-16-17-64-18-19-65-20-21-67-48(6,7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-8-10-34(11-9-32)42-28(2)52-26-66-42/h8-15,26,36-38,43,60H,16-25H2,1-7H3,(H,50,61)(H,51,62)(H,53,59)/t36-,37+,38+,43+/m1/s1","ZCEIHPCVOJGWHG-GMEZEQRCSA-N"
"316","","BCR-ABL","CRBN","","BOS-6-2-2-CRBN","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCOCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","","","","","","","","","0.28/0.11","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","973.912","972.333995288","6.17","68","7","15","3","23","213.99","C48H54Cl2N8O10","InChI=1S/C48H54Cl2N8O10/c1-64-39-26-37(33(49)24-34(39)50)54-45-30(27-51)28-52-36-25-41(40(65-2)23-32(36)45)68-20-8-14-57-17-15-56(16-18-57)13-5-3-4-6-19-66-21-22-67-29-43(60)53-35-10-7-9-31-44(35)48(63)58(47(31)62)38-11-12-42(59)55-46(38)61/h7,9-10,23-26,28,38H,3-6,8,11-22,29H2,1-2H3,(H,52,54)(H,53,60)(H,55,59,61)","OHGOKRHLLKPKJK-UHFFFAOYSA-N"
"317","","BCR-ABL","CRBN","","BOS-6-2-2-6-CRBN","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCOCCOCCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","","","","","","","","","0.91/0.55","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1074.073","1072.42281029","7.0","75","7","16","3","30","223.22","C54H66Cl2N8O11","InChI=1S/C54H66Cl2N8O11/c1-70-45-33-43(39(55)31-40(45)56)60-51-36(34-57)35-58-42-32-47(46(71-2)30-38(42)51)75-25-11-18-63-21-19-62(20-22-63)17-7-3-4-8-23-72-26-28-74-29-27-73-24-9-5-6-14-48(65)59-41-13-10-12-37-50(41)54(69)64(53(37)68)44-15-16-49(66)61-52(44)67/h10,12-13,30-33,35,44H,3-9,11,14-29H2,1-2H3,(H,58,60)(H,59,65)(H,61,66,67)","MKHTUOFMIYFSEP-UHFFFAOYSA-N"
"318","","BCR-ABL","CRBN","","BOS-6-5-6-CRBN","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCCCCOCCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","","","","","","","","","2.8/1.1","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1072.101","1070.44354574","8.21","75","7","15","3","30","213.99","C55H68Cl2N8O10","InChI=1S/C55H68Cl2N8O10/c1-71-46-34-44(40(56)32-41(46)57)61-52-37(35-58)36-59-43-33-48(47(72-2)31-39(43)52)75-30-14-21-64-24-22-63(23-25-64)20-8-3-4-9-26-73-28-11-6-12-29-74-27-10-5-7-17-49(66)60-42-16-13-15-38-51(42)55(70)65(54(38)69)45-18-19-50(67)62-53(45)68/h13,15-16,31-34,36,45H,3-12,14,17-30H2,1-2H3,(H,59,61)(H,60,66)(H,62,67,68)","CDTZGURPZDTZAF-UHFFFAOYSA-N"
"319","","BCR-ABL","CRBN","","BOS-6-2-2-2-2-2-2-CRBN","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","","","","","","","","","0.38/0.13","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1150.124","1148.43885428","5.58","80","7","19","3","35","250.91","C56H70Cl2N8O14","InChI=1S/C56H70Cl2N8O14/c1-72-47-34-45(41(57)32-42(47)58)62-53-38(35-59)36-60-44-33-49(48(73-2)31-40(44)53)80-20-8-14-65-17-15-64(16-18-65)13-5-3-4-6-19-74-21-22-75-23-24-76-25-26-77-27-28-78-29-30-79-37-51(68)61-43-10-7-9-39-52(43)56(71)66(55(39)70)46-11-12-50(67)63-54(46)69/h7,9-10,31-34,36,46H,3-6,8,11-30,37H2,1-2H3,(H,60,62)(H,61,68)(H,63,67,69)","RBQXHLBIJMHVHI-UHFFFAOYSA-N"
"320","","BCR-ABL","VHL","","DAS-6-2-2-VHL","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","","","","","","","0.36/0.21","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1058.773","1057.4433132","7.52","73","7","16","5","23","216.37","C52H68ClN11O7S2","InChI=1S/C52H68ClN11O7S2/c1-33-12-11-13-39(53)45(33)61-49(68)41-29-55-51(73-41)59-42-27-43(58-35(3)57-42)63-21-19-62(20-22-63)18-9-7-8-10-23-70-24-25-71-31-44(66)60-47(52(4,5)6)50(69)64-30-38(65)26-40(64)48(67)54-28-36-14-16-37(17-15-36)46-34(2)56-32-72-46/h11-17,27,29,32,38,40,47,65H,7-10,18-26,28,30-31H2,1-6H3,(H,54,67)(H,60,66)(H,61,68)(H,55,57,58,59)/t38-,40+,47-/m1/s1","KVDHKHPORALHHP-LISSLODSSA-N"
"321","","BCR-ABL","VHL","","DAS-6-2-2-6-VHL","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","","","","","","","0.92/0.47","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1158.934","1157.5321282","8.35","80","7","17","5","30","225.6","C58H80ClN11O8S2","InChI=1S/C58H80ClN11O8S2/c1-39-15-14-16-45(59)51(39)67-55(74)47-36-61-57(80-47)65-48-34-49(64-41(3)63-48)69-25-23-68(24-26-69)22-11-7-8-12-27-76-29-31-78-32-30-77-28-13-9-10-17-50(72)66-53(58(4,5)6)56(75)70-37-44(71)33-46(70)54(73)60-35-42-18-20-43(21-19-42)52-40(2)62-38-79-52/h14-16,18-21,34,36,38,44,46,53,71H,7-13,17,22-33,35,37H2,1-6H3,(H,60,73)(H,66,72)(H,67,74)(H,61,63,64,65)/t44-,46+,53-/m1/s1","MQXNKLLRIGGEOE-NJZQEGHZSA-N"
"321","","BCR-ABL","VHL","","DAS-6-2-2-6-VHL","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.4","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1158.934","1157.5321282","8.35","80","7","17","5","30","225.6","C58H80ClN11O8S2","InChI=1S/C58H80ClN11O8S2/c1-39-15-14-16-45(59)51(39)67-55(74)47-36-61-57(80-47)65-48-34-49(64-41(3)63-48)69-25-23-68(24-26-69)22-11-7-8-12-27-76-29-31-78-32-30-77-28-13-9-10-17-50(72)66-53(58(4,5)6)56(75)70-37-44(71)33-46(70)54(73)60-35-42-18-20-43(21-19-42)52-40(2)62-38-79-52/h14-16,18-21,34,36,38,44,46,53,71H,7-13,17,22-33,35,37H2,1-6H3,(H,60,73)(H,66,72)(H,67,74)(H,61,63,64,65)/t44-,46+,53-/m1/s1","MQXNKLLRIGGEOE-NJZQEGHZSA-N"
"322","","BCR-ABL","VHL","","DAS-6-5-6-VHL","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","","","","","","","2.6/1.3","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1156.962","1155.55286364","9.56","80","7","16","5","30","216.37","C59H82ClN11O7S2","InChI=1S/C59H82ClN11O7S2/c1-40-18-17-19-46(60)52(40)68-56(75)48-37-62-58(80-48)66-49-35-50(65-42(3)64-49)70-28-26-69(27-29-70)25-12-7-8-13-30-77-32-15-10-16-33-78-31-14-9-11-20-51(73)67-54(59(4,5)6)57(76)71-38-45(72)34-47(71)55(74)61-36-43-21-23-44(24-22-43)53-41(2)63-39-79-53/h17-19,21-24,35,37,39,45,47,54,72H,7-16,20,25-34,36,38H2,1-6H3,(H,61,74)(H,67,73)(H,68,75)(H,62,64,65,66)/t45-,47+,54-/m1/s1","YMBLWVSJIPMYJG-VPJSRUKDSA-N"
"323","","BCR-ABL","VHL","","DAS-6-2-2-2-2-2-2-VHL","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","","","","","","","0.28/0.088","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1234.985","1233.54817219","6.93","85","7","20","5","35","253.29","C60H84ClN11O11S2","InChI=1S/C60H84ClN11O11S2/c1-41-12-11-13-47(61)53(41)69-57(76)49-37-63-59(85-49)67-50-35-51(66-43(3)65-50)71-21-19-70(20-22-71)18-9-7-8-10-23-78-24-25-79-26-27-80-28-29-81-30-31-82-32-33-83-39-52(74)68-55(60(4,5)6)58(77)72-38-46(73)34-48(72)56(75)62-36-44-14-16-45(17-15-44)54-42(2)64-40-84-54/h11-17,35,37,40,46,48,55,73H,7-10,18-34,36,38-39H2,1-6H3,(H,62,75)(H,68,74)(H,69,76)(H,63,65,66,67)/t46-,48+,55-/m1/s1","CZHIVNNGAXNFBN-YWVZRUCESA-N"
"324","","BCR-ABL","CRBN","","DAS-6-2-2-CRBN","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","0.28/0.19","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","901.447","900.314407208","5.06","63","7","15","4","19","217.39","C43H49ClN10O8S","InChI=1S/C43H49ClN10O8S/c1-26-9-7-11-29(44)38(26)51-40(58)32-24-45-43(63-32)49-33-23-34(47-27(2)46-33)53-18-16-52(17-19-53)15-5-3-4-6-20-61-21-22-62-25-36(56)48-30-12-8-10-28-37(30)42(60)54(41(28)59)31-13-14-35(55)50-39(31)57/h7-12,23-24,31H,3-6,13-22,25H2,1-2H3,(H,48,56)(H,51,58)(H,50,55,57)(H,45,46,47,49)","DFJPUNQJXZZGBH-UHFFFAOYSA-N"
"325","","BCR-ABL","CRBN","","DAS-6-2-2-6-CRBN","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","0.6/0.32","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.4","Inhibit viability of K562 cells","","","","","","","","","","","","","10.1002/anie.201507634","1001.608","1000.40322221","5.89","70","7","16","4","26","226.62","C49H61ClN10O9S","InChI=1S/C49H61ClN10O9S/c1-32-12-10-14-35(50)44(32)57-46(64)38-31-51-49(70-38)55-39-30-40(53-33(2)52-39)59-22-20-58(21-23-59)19-7-3-4-8-24-67-26-28-69-29-27-68-25-9-5-6-16-41(61)54-36-15-11-13-34-43(36)48(66)60(47(34)65)37-17-18-42(62)56-45(37)63/h10-15,30-31,37H,3-9,16-29H2,1-2H3,(H,54,61)(H,57,64)(H,56,62,63)(H,51,52,53,55)","JBMSSKLUVBBAHN-UHFFFAOYSA-N"
"325","","BCR-ABL","CRBN","","DAS-6-2-2-6-CRBN","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8","Inhibit viability of K562 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1001.608","1000.40322221","5.89","70","7","16","4","26","226.62","C49H61ClN10O9S","InChI=1S/C49H61ClN10O9S/c1-32-12-10-14-35(50)44(32)57-46(64)38-31-51-49(70-38)55-39-30-40(53-33(2)52-39)59-22-20-58(21-23-59)19-7-3-4-8-24-67-26-28-69-29-27-68-25-9-5-6-16-41(61)54-36-15-11-13-34-43(36)48(66)60(47(34)65)37-17-18-42(62)56-45(37)63/h10-15,30-31,37H,3-9,16-29H2,1-2H3,(H,54,61)(H,57,64)(H,56,62,63)(H,51,52,53,55)","JBMSSKLUVBBAHN-UHFFFAOYSA-N"
"326","","BCR-ABL","CRBN","","DAS-6-5-6-CRBN","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCCCCOCCCCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","1.3/1.4","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","999.636","998.423957656","7.11","70","7","15","4","26","217.39","C50H63ClN10O8S","InChI=1S/C50H63ClN10O8S/c1-33-15-13-17-36(51)45(33)58-47(65)39-32-52-50(70-39)56-40-31-41(54-34(2)53-40)60-25-23-59(24-26-60)22-8-3-4-9-27-68-29-11-6-12-30-69-28-10-5-7-19-42(62)55-37-18-14-16-35-44(37)49(67)61(48(35)66)38-20-21-43(63)57-46(38)64/h13-18,31-32,38H,3-12,19-30H2,1-2H3,(H,55,62)(H,58,65)(H,57,63,64)(H,52,53,54,56)","VLSUHXVLUHCGTB-UHFFFAOYSA-N"
"327","","BCR-ABL","CRBN","","DAS-6-2-2-2-2-2-2-CRBN","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","0.26/0.23","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1077.659","1076.4192662","4.47","75","7","19","4","31","254.31","C51H65ClN10O12S","InChI=1S/C51H65ClN10O12S/c1-34-9-7-11-37(52)46(34)59-48(66)40-32-53-51(75-40)57-41-31-42(55-35(2)54-41)61-18-16-60(17-19-61)15-5-3-4-6-20-69-21-22-70-23-24-71-25-26-72-27-28-73-29-30-74-33-44(64)56-38-12-8-10-36-45(38)50(68)62(49(36)67)39-13-14-43(63)58-47(39)65/h7-12,31-32,39H,3-6,13-30,33H2,1-2H3,(H,56,64)(H,59,66)(H,58,63,65)(H,53,54,55,57)","FGTNRYWAENEKJL-UHFFFAOYSA-N"
"328","P25440","BRD2","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.43/7.45/2.4","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"328","Q15059","BRD3","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.43/7.45/2.4","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"328","O60885","BRD4","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.43/7.45/2.4","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"328","P25440","BRD2","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","<5/<5/<5","","Degradation of BRD2 in 22Rv1/VCaP/LnCaP95 cells after 16 h treatment","","","","","","","34/4.7","Kd of BRD2 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Suppression of cellular c-MYC levels measured by ELISA","","","","","","","","","","","","","","","10.1073/pnas.1521738113","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"328","Q15059","BRD3","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","<5/<5/<5","","Degradation of BRD3 in 22Rv1/VCaP/LnCaP95 cells after 16 h treatment","","","","","","","8.3/7.6","Kd of BRD3 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Suppression of cellular c-MYC levels measured by ELISA","","","","","","","","","","","","","","","10.1073/pnas.1521738113","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"328","O60885","BRD4","VHL","","ARV-771","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","<5/<5/<5","","Degradation of BRD4 in 22Rv1/VCaP/LnCaP95 cells after 16 h treatment","","","","","","","9.6/7.6","Kd of BRD4 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Suppression of cellular c-MYC levels measured by ELISA","","","","","","","","","0.2","PAMPA assay","","","","","10.1073/pnas.1521738113; 10.1021/acs.jmedchem.1c01496","986.662","985.37456494","5.87","68","7","14","4","18","202.26","C49H60ClN9O7S2","InChI=1S/C49H60ClN9O7S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)54-37(45-57-56-31(5)59(45)48)23-39(61)51-18-21-65-19-9-20-66-25-40(62)55-44(49(6,7)8)47(64)58-24-36(60)22-38(58)46(63)53-28(2)32-10-12-34(13-11-32)43-29(3)52-26-67-43/h10-17,26,28,36-38,44,60H,9,18-25H2,1-8H3,(H,51,61)(H,53,63)(H,55,62)/t28-,36+,37-,38-,44+/m0/s1","PQOGZKGXGLHDGS-QQRWPDCKSA-N"
"329","P25440","BRD2","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2015.05.009","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","Q15059","BRD3","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2015.05.009","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","P25440","BRD2","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.05/18.2/3.3","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","Q15059","BRD3","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.05/18.2/3.3","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","O60885","BRD4","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.05/18.2/3.3","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","P25440","BRD2","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","6","83","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17/35","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","Q15059","BRD3","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","0.8","98","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17/35","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","O60885","BRD4","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","<1/<1","","Degradation of BRD4 in Namalwa/CA-46 cells after overnight treatment","","","","","","","90/28","Kd of BRD4 BD1/2 was determined with BROMOscan","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2015.05.009","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","O60885","BRD4","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","0.57","","Degradation of BRD4 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.023","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"329","O60885","BRD4","CRBN","","ARV-825","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NC1=CC=C(OCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)N=C2C1=CC=C(Cl)C=C1","0.6/1","97/100","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17/35","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","923.449","922.287523764","4.81","65","8","15","3","19","204.67","C46H47ClN8O9S","InChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,15-25H2,1-3H3,(H,49,57)(H,51,56,58)/t35-,36?/m0/s1","RWLOGRLTDKDANT-TYIYNAFKSA-N"
"330","P25440","BRD2","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","19/11","Kd of BRD2 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/science.aab1433","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","Q15059","BRD3","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","8.9/10","Kd of BRD3 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/science.aab1433","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","P25440","BRD2","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","78.8/657","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","Q15059","BRD3","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","78.8/657","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","78.8/657","Inhibit growth of RS4;11/MOLM-13 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01816","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","P25440","BRD2","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42/140/79","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","Q15059","BRD3","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42/140/79","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42/140/79","Inhibit growth of MV4;11/MOLM-13/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b00506","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","P25440","BRD2","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","115.3/11.5/863.7","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","Q15059","BRD3","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","115.3/11.5/863.7","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","115.3/11.5/863.7","Inhibit proliferation of MM.1S/MV-4-11/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.orglett.9b01326","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","430","","Degradation of BRD4 in SUM149 cells after 18 h treatment","","","","","","","7/6","Kd of BRD4 BD1/2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/science.aab1433","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","500/1000","","Degradation of BRD4 BD1/2 assessed by EGFP/mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","5.27/2.9","","Degradation of BRD4 in MV4-11 cells after 12/24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.6","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"330","O60885","BRD4","CRBN","","dBET1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","230","","Degradation of BRD4 in HD-MB03 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202108848","785.283","784.219444204","3.22","55","7","12","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-20(2)55-38-31(19)33(22-9-11-23(39)12-10-22)42-25(34-45-44-21(3)46(34)38)17-29(49)40-15-4-5-16-41-30(50)18-54-27-8-6-7-24-32(27)37(53)47(36(24)52)26-13-14-28(48)43-35(26)51/h6-12,25-26H,4-5,13-18H2,1-3H3,(H,40,49)(H,41,50)(H,43,48,51)/t25-,26?/m0/s1","LKEGXJXRNBALBV-PMCHYTPCSA-N"
"331","P62942","FKBP12","CRBN","","dFKBP-1","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)CCC(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/science.aab1433","1009.123","1008.44805073","4.24","73","6","14","4","24","262.22","C53H64N6O14","InChI=1S/C53H64N6O14/c1-6-53(2,3)47(64)51(68)58-28-10-7-16-37(58)52(69)73-38(21-18-32-19-22-39(70-4)41(29-32)71-5)33-13-11-14-34(30-33)56-43(61)25-24-42(60)54-26-8-9-27-55-45(63)31-72-40-17-12-15-35-46(40)50(67)59(49(35)66)36-20-23-44(62)57-48(36)65/h11-15,17,19,22,29-30,36-38H,6-10,16,18,20-21,23-28,31H2,1-5H3,(H,54,60)(H,55,63)(H,56,61)(H,57,62,65)/t36?,37-,38+/m0/s1","RIBCWKRMNKOGRN-GGJINPDOSA-N"
"332","P62942","FKBP12","CRBN","","dFKBP-2","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/science.aab1433","1141.282","1140.52669497","3.79","82","6","17","4","33","289.91","C59H76N6O17","InChI=1S/C59H76N6O17/c1-6-59(2,3)53(70)57(74)64-28-8-7-16-43(64)58(75)82-44(21-18-38-19-22-45(76-4)47(35-38)77-5)39-13-9-14-40(36-39)62-49(67)25-24-48(66)60-26-11-29-78-31-33-80-34-32-79-30-12-27-61-51(69)37-81-46-17-10-15-41-52(46)56(73)65(55(41)72)42-20-23-50(68)63-54(42)71/h9-10,13-15,17,19,22,35-36,42-44H,6-8,11-12,16,18,20-21,23-34,37H2,1-5H3,(H,60,66)(H,61,69)(H,62,67)(H,63,68,71)/t42?,43-,44+/m0/s1","PXXLBMHKRNFGTO-AYWDICMXSA-N"
"333","P11474","ERRalpha","VHL","","","COC1=CC(/C=C2\SC(=O)N(CCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C2=O)=CC=C1OC1=CC=C(C#N)C=C1C(F)(F)F","100","86","Degradation of ERRalpha in MCF-7 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.1858","949.043","948.279803744","6.35","66","6","13","3","16","200.49","C46H47F3N6O9S2","InChI=1S/C46H47F3N6O9S2/c1-26-39(65-25-52-26)30-10-6-27(7-11-30)23-51-41(58)33-21-31(56)24-55(33)43(60)40(45(2,3)4)53-38(57)14-16-63-17-15-54-42(59)37(66-44(54)61)20-28-8-13-35(36(19-28)62-5)64-34-12-9-29(22-50)18-32(34)46(47,48)49/h6-13,18-20,25,31,33,40,56H,14-17,21,23-24H2,1-5H3,(H,51,58)(H,53,57)/b37-20-/t31-,33+,40-/m1/s1","IIJORMBEWMYDEN-FRKKMCEPSA-N"
"334","O43353","RIPK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOC3=CC4=NC=CC(NC5=CC=C6SC=NC6=C5)=C4C=C3S(=O)(=O)C(C)(C)C)C(C)(C)C)C=C2)SC=N1","1.4","95","Degradation of RIPK2 in THP-1 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","656","Inhibition of VHL by competition binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.1858","1060.331","1059.3904189","5.91","73","7","17","4","24","229.73","C52H65N7O11S3","InChI=1S/C52H65N7O11S3/c1-33-47(72-31-55-33)35-10-8-34(9-11-35)28-54-49(62)42-25-37(60)29-59(42)50(63)48(51(2,3)4)58-46(61)30-69-21-20-67-17-16-66-18-19-68-22-23-70-43-27-40-38(26-45(43)73(64,65)52(5,6)7)39(14-15-53-40)57-36-12-13-44-41(24-36)56-32-71-44/h8-15,24,26-27,31-32,37,42,48,60H,16-23,25,28-30H2,1-7H3,(H,53,57)(H,54,62)(H,58,61)/t37-,42+,48-/m1/s1","RIEGJNXDHULIKM-GPPJZCFZSA-N"
"334","O43353","RIPK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOC3=CC4=NC=CC(NC5=CC=C6SC=NC6=C5)=C4C=C3S(=O)(=O)C(C)(C)C)C(C)(C)C)C=C2)SC=N1","2","","Degradation of RIPK2 in THP-1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-020-0868-6","1060.331","1059.3904189","5.91","73","7","17","4","24","229.73","C52H65N7O11S3","InChI=1S/C52H65N7O11S3/c1-33-47(72-31-55-33)35-10-8-34(9-11-35)28-54-49(62)42-25-37(60)29-59(42)50(63)48(51(2,3)4)58-46(61)30-69-21-20-67-17-16-66-18-19-68-22-23-70-43-27-40-38(26-45(43)73(64,65)52(5,6)7)39(14-15-53-40)57-36-12-13-44-41(24-36)56-32-71-44/h8-15,24,26-27,31-32,37,42,48,60H,16-23,25,28-30H2,1-7H3,(H,53,57)(H,54,62)(H,58,61)/t37-,42+,48-/m1/s1","RIEGJNXDHULIKM-GPPJZCFZSA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","307/228","ITC in BRD2 BD1/2","","","-9.05/-9.22","-10/-6.08","1.3/-3.12","ITC in BRD2 BD1/2","","","","","","","","","149","ITC","","","-9.47","-6.87","-2.44","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.01","PAMPA assay","","","","","10.1021/acschembio.5b00216; 10.1021/acs.jmedchem.1c01496","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","119/115","ITC in BRD3 BD1/2","","","-9.62/-9.63","-10/-8.32","1.33/1.3","ITC in BRD3 BD1/2","","","","","","","","","149","ITC","","","-9.47","-6.87","-2.44","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.5b00216","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","382/120","ITC in BRD4 BD1/2","","","-8.91/-9.61","-8.59/-6.86","-0.32/-2.74","ITC in BRD4 BD1/2","","","","","","","","","149","ITC","","","-9.47","-6.87","-2.44","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.5b00216","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50","Inhibit proliferation of MV4;11 cells","","","","","","","","","","","","","10.1021/jacs.8b05807","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","62/60","ITC in BRD2 BD1/2","","","-9.84/-9.85","-12.8/-9.8","3/-0.1","ITC in BRD2 BD1/2","","","","","","","","","66","ITC","","","-9.81","-7.7","-2.1","ITC","","","","","","","","","24/28","Kd between VHL and MZ1-BRD2 BD1/BD2 was tested by ITC","","","-10.4/-10.3","-7.3/-10.5","-3.1/0.2","ITC between VHL and MZ1-BRD2 BD1/BD2","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","21/13","ITC in BRD3 BD1/2","","","-10.2/-10.8","-14.7/-14","4.2/3.3","ITC in BRD3 BD1/2","","","","","","","","","66","ITC","","","-9.81","-7.7","-2.1","ITC","","","","","","","","","19/7","Kd between VHL and MZ1-BRD3 BD1/BD2 was tested by ITC","","","-10.6/-11.2","-8.8/-6.3","-1.8/-4.9","ITC between VHL and MZ1-BRD3 BD1/BD2","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","39/15","ITC in BRD4 BD1/2","","","-10.1/-10.68","-14.7/-10.9","4.6/0.2","ITC in BRD4 BD1/2","","","","","","","","","66","ITC","","","-9.81","-7.7","-2.1","ITC","","","","","","","","","28/3.7","Kd between VHL and MZ1-BRD4 BD1/BD2 was tested by ITC","","","-10.3/-11.5","-9.1/-8.9","-1/-2.6","ITC between VHL and MZ1-BRD4 BD1/BD2","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2329","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","77","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","77","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","77","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","29","SPR","72","FP","","","","","700000","0.019","43","SPR","","","","","23/0.9","Kd between VHL and MZ1-BRD2 BD1/BD2 was tested by SPR","33/2.5","Ki between VHL and MZ1-BRD2 BD1/BD2 was tested by FP","","","","","3.9E+8/1.2E+7",">1/0.01","<0.7/67.4","SPR between VHL and MZ1-BRD2 BD1/2","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","29","SPR","72","FP","","","","","700000","0.019","43","SPR","","","","","12/8","Kd between VHL and MZ1-BRD3 BD1/BD2 was tested by SPR","18/8","Ki between VHL and MZ1-BRD3 BD1/BD2 was tested by FP","","","","","1.4E+8/1.6E+7",">1/0.12","<0.7/6","SPR between VHL and MZ1-BRD3 BD1/2","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","29","SPR","72","FP","","","","","700000","0.019","43","SPR","","","","","30/1","Kd between VHL and MZ1-BRD4 BD1/BD2 was tested by SPR","13/1.3","Ki between VHL and MZ1-BRD4 BD1/BD2 was tested by FP","","","","","7E+7/5.9E+6",">1/0.006","<0.7/130","SPR between VHL and MZ1-BRD4 BD1/2","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","P25440","BRD2","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","40","98","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","69","ITC","","","-9.77","-7.76","-2.02","ITC","","","","","","","","","","","","","","","","","","","","","","","27/219","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","Q15059","BRD3","VHL","","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","100","100","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","69","ITC","","","-9.77","-7.76","-2.02","ITC","","","","","","","","","","","","","","","","","","","","","","","27/219","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"335","O60885","BRD4","VHL","5T35","MZ1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","8/3","98/100","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","26","ITC in BRD4 BD2","","","-10.3","-11.1","0.77","ITC in BRD4 BD2","","","","","","","","","69","ITC","","","-9.77","-7.76","-2.02","ITC","","","","","","","","","9","Kd between VHL and MZ1-BRD4 BD2 was tested by ITC","","","-11.1","-8.47","-2.59","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","27/219","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1002.661","1001.36947956","4.96","69","7","15","4","20","211.49","C49H60ClN9O8S2","InChI=1S/C49H60ClN9O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","PTAMRJLIOCHJMQ-PYNGZGNASA-N"
"336","P25440","BRD2","VHL","","MZ2","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","200","97","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","73","ITC","","","-9.75","-8.79","-0.96","ITC","","","","","","","","","","","","","","","","","","","","","","","123/1259","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912; 10.1021/acschembio.5b00216","1046.714","1045.39569431","4.82","72","7","16","4","23","220.72","C51H64ClN9O9S2","InChI=1S/C51H64ClN9O9S2/c1-30-32(3)72-50-43(30)44(35-12-14-37(52)15-13-35)56-39(47-59-58-33(4)61(47)50)25-41(63)53-16-17-67-18-19-68-20-21-69-22-23-70-28-42(64)57-46(51(5,6)7)49(66)60-27-38(62)24-40(60)48(65)54-26-34-8-10-36(11-9-34)45-31(2)55-29-71-45/h8-15,29,38-40,46,62H,16-28H2,1-7H3,(H,53,63)(H,54,65)(H,57,64)/t38-,39+,40+,46-/m1/s1","LSELSHXLKGXPPF-BOBBFQORSA-N"
"336","Q15059","BRD3","VHL","","MZ2","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","316","99","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","73","ITC","","","-9.75","-8.79","-0.96","ITC","","","","","","","","","","","","","","","","","","","","","","","123/1259","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912; 10.1021/acschembio.5b00216","1046.714","1045.39569431","4.82","72","7","16","4","23","220.72","C51H64ClN9O9S2","InChI=1S/C51H64ClN9O9S2/c1-30-32(3)72-50-43(30)44(35-12-14-37(52)15-13-35)56-39(47-59-58-33(4)61(47)50)25-41(63)53-16-17-67-18-19-68-20-21-69-22-23-70-28-42(64)57-46(51(5,6)7)49(66)60-27-38(62)24-40(60)48(65)54-26-34-8-10-36(11-9-34)45-31(2)55-29-71-45/h8-15,29,38-40,46,62H,16-28H2,1-7H3,(H,53,63)(H,54,65)(H,57,64)/t38-,39+,40+,46-/m1/s1","LSELSHXLKGXPPF-BOBBFQORSA-N"
"336","O60885","BRD4","VHL","","MZ2","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","4/10","99/100","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","27","ITC in BRD4 BD2","","","-10.3","-10.6","0.31","ITC in BRD4 BD2","","","","","","","","","73","ITC","","","-9.75","-8.79","-0.96","ITC","","","","","","","","","15","Kd between VHL and MZ2-BRD4 BD2 was tested by ITC","","","-10.7","-10.6","-0.07","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","123/1259","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912; 10.1021/acschembio.5b00216","1046.714","1045.39569431","4.82","72","7","16","4","23","220.72","C51H64ClN9O9S2","InChI=1S/C51H64ClN9O9S2/c1-30-32(3)72-50-43(30)44(35-12-14-37(52)15-13-35)56-39(47-59-58-33(4)61(47)50)25-41(63)53-16-17-67-18-19-68-20-21-69-22-23-70-28-42(64)57-46(51(5,6)7)49(66)60-27-38(62)24-40(60)48(65)54-26-34-8-10-36(11-9-34)45-31(2)55-29-71-45/h8-15,29,38-40,46,62H,16-28H2,1-7H3,(H,53,63)(H,54,65)(H,57,64)/t38-,39+,40+,46-/m1/s1","LSELSHXLKGXPPF-BOBBFQORSA-N"
"337","P25440","BRD2","VHL","","MZ3","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","311","ITC","","","-9.04","-4.9","-4","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.5b00216","1149.838","1148.43789347","6.3","80","8","16","5","24","240.59","C58H69ClN10O9S2","InChI=1S/C58H69ClN10O9S2/c1-34-36(3)80-57-49(34)50(40-17-19-42(59)20-18-40)64-44(53-67-66-37(4)69(53)57)29-47(71)60-21-22-76-23-24-77-25-26-78-32-48(72)63-45(27-38-11-9-8-10-12-38)54(73)65-52(58(5,6)7)56(75)68-31-43(70)28-46(68)55(74)61-30-39-13-15-41(16-14-39)51-35(2)62-33-79-51/h8-20,33,43-46,52,70H,21-32H2,1-7H3,(H,60,71)(H,61,74)(H,63,72)(H,65,73)/t43-,44+,45+,46+,52-/m1/s1","ANYWTMNSSMEZSK-GQCKFWBASA-N"
"337","Q15059","BRD3","VHL","","MZ3","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","311","ITC","","","-9.04","-4.9","-4","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.5b00216","1149.838","1148.43789347","6.3","80","8","16","5","24","240.59","C58H69ClN10O9S2","InChI=1S/C58H69ClN10O9S2/c1-34-36(3)80-57-49(34)50(40-17-19-42(59)20-18-40)64-44(53-67-66-37(4)69(53)57)29-47(71)60-21-22-76-23-24-77-25-26-78-32-48(72)63-45(27-38-11-9-8-10-12-38)54(73)65-52(58(5,6)7)56(75)68-31-43(70)28-46(68)55(74)61-30-39-13-15-41(16-14-39)51-35(2)62-33-79-51/h8-20,33,43-46,52,70H,21-32H2,1-7H3,(H,60,71)(H,61,74)(H,63,72)(H,65,73)/t43-,44+,45+,46+,52-/m1/s1","ANYWTMNSSMEZSK-GQCKFWBASA-N"
"337","O60885","BRD4","VHL","","MZ3","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","311","ITC","","","-9.04","-4.9","-4","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.5b00216","1149.838","1148.43789347","6.3","80","8","16","5","24","240.59","C58H69ClN10O9S2","InChI=1S/C58H69ClN10O9S2/c1-34-36(3)80-57-49(34)50(40-17-19-42(59)20-18-40)64-44(53-67-66-37(4)69(53)57)29-47(71)60-21-22-76-23-24-77-25-26-78-32-48(72)63-45(27-38-11-9-8-10-12-38)54(73)65-52(58(5,6)7)56(75)68-31-43(70)28-46(68)55(74)61-30-39-13-15-41(16-14-39)51-35(2)62-33-79-51/h8-20,33,43-46,52,70H,21-32H2,1-7H3,(H,60,71)(H,61,74)(H,63,72)(H,65,73)/t43-,44+,45+,46+,52-/m1/s1","ANYWTMNSSMEZSK-GQCKFWBASA-N"
"338","P10275","AR","MDM2","","","COC1=CC=C(C2=N[C@H](C3=CC=C(Cl)C=C3)[C@H](C3=CC=C(Cl)C=C3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCC(=O)NC3=CC=C(OC[C@](C)(O)C(=O)NC4=CC=C([N+](=O)[O-])C(C(F)(F)F)=C4)C=C3)C(=O)C2)C(OC(C)C)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2008.07.114","1210.057","1208.36363865","6.31","84","7","15","4","26","262.27","C57H61Cl2F3N8O14","InChI=1S/C57H61Cl2F3N8O14/c1-35(2)84-47-30-43(79-4)18-19-44(47)53-66-51(36-5-9-38(58)10-6-36)52(37-7-11-39(59)12-8-37)69(53)55(75)68-23-22-67(50(73)32-68)31-48(71)63-21-24-80-25-26-81-27-28-82-33-49(72)64-40-13-16-42(17-14-40)83-34-56(3,76)54(74)65-41-15-20-46(70(77)78)45(29-41)57(60,61)62/h5-20,29-30,35,51-52,76H,21-28,31-34H2,1-4H3,(H,63,71)(H,64,72)(H,65,74)/t51-,52+,56+/m1/s1","VKTBFTIPDGAIPC-BIOIQHPWSA-N"
"339","Q15059","BRD3","CRBN","","dBET6","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","841.391","840.28204446","5.02","59","7","12","3","16","194.05","C42H45ClN8O7S","InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1","JGQPZPLJOBHHBK-UFXYQILXSA-N"
"339","O60885","BRD4","CRBN","6BOY","dBET6","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","10/50","","Degradation of BRD4 BD1/2 assessed by EGFP/mCherry reporter assay","","","","","","","","","","","","","","","","","","","800","Inhibition of CRBN by competition binding assay","","","","","","","","","","","","","","","1800/4100","Inhibition of CRBN in the presence of BRD4 BD1/2 by competition binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","841.391","840.28204446","5.02","59","7","12","3","16","194.05","C42H45ClN8O7S","InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1","JGQPZPLJOBHHBK-UFXYQILXSA-N"
"339","O60885","BRD4","CRBN","6BOY","dBET6","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","6","97","Degradation of BRD4 in HEK293T cells after 3 h treatment","","","","","","","46","Kd of BRD4 BD1 was assessed by FP","","","","","","","","","","","","","","","264","FP","","","","","","","","","","","","","","","33","Kd was tested by AlphaLISA assay","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00376","841.391","840.28204446","5.02","59","7","12","3","16","194.05","C42H45ClN8O7S","InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1","JGQPZPLJOBHHBK-UFXYQILXSA-N"
"339","P25440","BRD2 BD2","CRBN","","dBET6","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCNC(=O)COC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","841.391","840.28204446","5.02","59","7","12","3","16","194.05","C42H45ClN8O7S","InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1","JGQPZPLJOBHHBK-UFXYQILXSA-N"
"340","O60885","BRD4","CRBN","6BN7","dBET23","COC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C(=O)NCCCCCCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2C)N2C(C)=NN=C12","50/>1000","","Degradation of BRD4 BD1/2 assessed by EGFP/mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","885.4","884.2718737","4.81","62","7","14","3","17","220.35","C43H45ClN8O9S","InChI=1S/C43H45ClN8O9S/c1-23-34-36(25-13-15-26(44)16-14-25)47-28(21-33(55)60-3)38-50-49-24(2)51(38)43(34)62-37(23)40(57)46-20-9-7-5-4-6-8-19-45-32(54)22-61-30-12-10-11-27-35(30)42(59)52(41(27)58)29-17-18-31(53)48-39(29)56/h10-16,28-29H,4-9,17-22H2,1-3H3,(H,45,54)(H,46,57)(H,48,53,56)/t28-,29?/m0/s1","ZIHIUFZFPMILIG-XLTVJXRZSA-N"
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"350","O60885","BRD4 BD1","CRBN","","ZXH-3-26","COC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C(=O)NCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2C)N2C(C)=NN=C12","5","","Degradation of BRD4 BD1 assessed by EGFP/mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-018-0055-y","785.283","784.219444204","4.58","55","7","13","3","12","194.05","C38H37ClN8O7S","InChI=1S/C38H37ClN8O7S/c1-19-29-31(21-10-12-22(39)13-11-21)42-25(18-28(49)54-3)33-45-44-20(2)46(33)38(29)55-32(19)35(51)41-17-6-4-5-16-40-24-9-7-8-23-30(24)37(53)47(36(23)52)26-14-15-27(48)43-34(26)50/h7-13,25-26,40H,4-6,14-18H2,1-3H3,(H,41,51)(H,43,48,50)/t25-,26?/m0/s1","OTKOFICOCDRNDA-PMCHYTPCSA-N"
"351","Q07820","MCL1","CRBN","","dMCL1-1","CC1=NN(C)C(COC2=CC=C(N3CCN(S(=O)(=O)N(C)C)CC3)C=C2)=C1C1=CC=CC2=C1N(CCN1CCN(C(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C(=O)O)=C2CCCOC1=CC=CC2=CC=CC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00455","1465.695","1464.64241048","1.96","105","11","21","4","37","324.59","C75H92N12O17S","InChI=1S/C75H92N12O17S/c1-51-68(61(81(4)79-51)49-103-54-24-22-53(23-25-54)83-37-39-85(40-38-83)105(97,98)80(2)3)58-17-8-16-56-57(19-10-44-102-62-20-7-14-52-13-5-6-15-55(52)62)71(75(95)96)86(70(56)58)41-34-82-32-35-84(36-33-82)67(91)29-28-64(88)76-30-11-42-99-45-47-101-48-46-100-43-12-31-77-66(90)50-104-63-21-9-18-59-69(63)74(94)87(73(59)93)60-26-27-65(89)78-72(60)92/h5-9,13-18,20-25,60H,10-12,19,26-50H2,1-4H3,(H,76,88)(H,77,90)(H,95,96)(H,78,89,92)","WCNNYDRGCNOWGG-UHFFFAOYSA-N"
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"354","P10275","AR","VHL","","","C#CC1=CC=C([C@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](C2=CC(C)=NO2)C(C)C)C=C1","","","","68/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1022.688","1021.4868752","8.46","74","8","10","3","13","181.34","C59H68ClN7O7","InChI=1S/C59H68ClN7O7/c1-9-38-12-16-41(17-13-38)48(62-54(71)49-31-45(68)35-67(49)55(72)52(36(2)3)50-30-37(4)64-74-50)33-51(69)66-28-24-44(25-29-66)65-26-22-40(23-27-65)11-10-39-14-18-42(19-15-39)53(70)63-56-58(5,6)57(59(56,7)8)73-46-21-20-43(34-61)47(60)32-46/h1,12-21,30,32,36,40,44-45,48-49,52,56-57,68H,22-29,31,33,35H2,2-8H3,(H,62,71)(H,63,70)/t45-,48+,49+,52-,56-,57-/m1/s1","KFBJDRLGRCWMLQ-RXFAPWBBSA-N"
"355","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(C#N)C=C2)C(C)C)=C1","","","","81/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1023.676","1022.48212416","7.94","74","8","11","3","13","205.13","C58H67ClN8O7","InChI=1S/C58H67ClN8O7/c1-35(2)51(49-28-36(3)64-74-49)54(72)67-34-44(68)29-48(67)53(71)62-47(40-14-12-39(32-60)13-15-40)31-50(69)66-26-22-43(23-27-66)65-24-20-38(21-25-65)9-8-37-10-16-41(17-11-37)52(70)63-55-57(4,5)56(58(55,6)7)73-45-19-18-42(33-61)46(59)30-45/h10-19,28,30,35,38,43-44,47-48,51,55-56,68H,20-27,29,31,34H2,1-7H3,(H,62,71)(H,63,70)/t44-,47+,48+,51-,55-,56-/m1/s1","BJJDMARRWANKSP-IXUVUIQXSA-N"
"356","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(Br)C=C2)C(C)C)=C1","","","","45/76/>95","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1077.562","1075.39738726","8.91","73","8","10","3","13","181.34","C57H67BrClN7O7","InChI=1S/C57H67BrClN7O7/c1-34(2)50(48-28-35(3)63-73-48)53(71)66-33-43(67)29-47(66)52(70)61-46(38-14-17-41(58)18-15-38)31-49(68)65-26-22-42(23-27-65)64-24-20-37(21-25-64)9-8-36-10-12-39(13-11-36)51(69)62-54-56(4,5)55(57(54,6)7)72-44-19-16-40(32-60)45(59)30-44/h10-19,28,30,34,37,42-43,46-47,50,54-55,67H,20-27,29,31,33H2,1-7H3,(H,61,70)(H,62,69)/t43-,46+,47+,50-,54-,55-/m1/s1","GECXGMVWVGLBOA-QBLJSAFHSA-N"
"357","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(Cl)C=C2)C(C)C)=C1","","","","85/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1033.111","1031.44790284","8.85","73","8","10","3","13","181.34","C57H67Cl2N7O7","InChI=1S/C57H67Cl2N7O7/c1-34(2)50(48-28-35(3)63-73-48)53(71)66-33-43(67)29-47(66)52(70)61-46(38-14-17-41(58)18-15-38)31-49(68)65-26-22-42(23-27-65)64-24-20-37(21-25-64)9-8-36-10-12-39(13-11-36)51(69)62-54-56(4,5)55(57(54,6)7)72-44-19-16-40(32-60)45(59)30-44/h10-19,28,30,34,37,42-43,46-47,50,54-55,67H,20-27,29,31,33H2,1-7H3,(H,61,70)(H,62,69)/t43-,46+,47+,50-,54-,55-/m1/s1","ZIPHSTZZNQZAOF-QBLJSAFHSA-N"
"358","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=C(F)C=C2)C(C)C)=C1","","","","92/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","1016.656","1015.47745338","8.32","73","8","10","3","13","181.34","C57H67ClFN7O7","InChI=1S/C57H67ClFN7O7/c1-34(2)50(48-28-35(3)63-73-48)53(71)66-33-43(67)29-47(66)52(70)61-46(38-14-17-41(59)18-15-38)31-49(68)65-26-22-42(23-27-65)64-24-20-37(21-25-64)9-8-36-10-12-39(13-11-36)51(69)62-54-56(4,5)55(57(54,6)7)72-44-19-16-40(32-60)45(58)30-44/h10-19,28,30,34,37,42-43,46-47,50,54-55,67H,20-27,29,31,33H2,1-7H3,(H,61,70)(H,62,69)/t43-,46+,47+,50-,54-,55-/m1/s1","SZGZCFNKKUVIIV-QBLJSAFHSA-N"
"359","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)CC2)C2=CC=CC=C2)C(C)C)=C1","","","","62/72/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","998.666","997.486875196","8.22","72","8","10","3","13","181.34","C57H68ClN7O7","InChI=1S/C57H68ClN7O7/c1-35(2)50(48-29-36(3)62-72-48)53(70)65-34-43(66)30-47(65)52(69)60-46(39-11-9-8-10-12-39)32-49(67)64-27-23-42(24-28-64)63-25-21-38(22-26-63)14-13-37-15-17-40(18-16-37)51(68)61-54-56(4,5)55(57(54,6)7)71-44-20-19-41(33-59)45(58)31-44/h8-12,15-20,29,31,35,38,42-43,46-47,50,54-55,66H,21-28,30,32,34H2,1-7H3,(H,60,69)(H,61,68)/t43-,46+,47+,50-,54-,55-/m1/s1","FSCPVRXZILXELV-QBLJSAFHSA-N"
"360","P10275","AR","VHL","","","CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(N2CCC(C#CC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(Cl)=C5)C4(C)C)C=C3)CC2)CC1)C1=CC=CC=C1)C(C)C","","","","8/11/17","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","974.644","973.486875196","7.08","70","7","9","4","13","184.41","C55H68ClN7O7","InChI=1S/C55H68ClN7O7/c1-34(2)48(58-35(3)64)51(69)63-33-42(65)29-46(63)50(68)59-45(38-11-9-8-10-12-38)31-47(66)62-27-23-41(24-28-62)61-25-21-37(22-26-61)14-13-36-15-17-39(18-16-36)49(67)60-52-54(4,5)53(55(52,6)7)70-43-20-19-40(32-57)44(56)30-43/h8-12,15-20,30,34,37,41-42,45-46,48,52-53,65H,21-29,31,33H2,1-7H3,(H,58,64)(H,59,68)(H,60,67)/t42-,45+,46+,48+,52-,53-/m1/s1","IOKVTDBHNXFCGP-UMGZQGGQSA-N"
"361","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)C3)CC2)C2=CC=CC=C2)C(C)C)=C1","","","","6/68/86","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","970.612","969.455575068","7.5","70","8","10","3","13","181.34","C55H64ClN7O7","InChI=1S/C55H64ClN7O7/c1-33(2)48(46-25-34(3)60-70-46)51(68)63-32-41(64)26-45(63)50(67)58-44(37-11-9-8-10-12-37)28-47(65)61-23-21-40(22-24-61)62-30-36(31-62)14-13-35-15-17-38(18-16-35)49(66)59-52-54(4,5)53(55(52,6)7)69-42-20-19-39(29-57)43(56)27-42/h8-12,15-20,25,27,33,36,40-41,44-45,48,52-53,64H,21-24,26,28,30-32H2,1-7H3,(H,58,67)(H,59,66)/t41-,44+,45+,48-,52-,53-/m1/s1","UWTHFHYBWWFQIY-PHLGFMGRSA-N"
"362","P10275","AR","VHL","","","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CC(N3CCC(C#CC4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)CC3)C2)C2=CC=CC=C2)C(C)C)=C1","","","","21/67/68","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","970.612","969.455575068","7.5","70","8","10","3","13","181.34","C55H64ClN7O7","InChI=1S/C55H64ClN7O7/c1-33(2)48(46-25-34(3)60-70-46)51(68)63-32-41(64)26-45(63)50(67)58-44(37-11-9-8-10-12-37)28-47(65)62-30-40(31-62)61-23-21-36(22-24-61)14-13-35-15-17-38(18-16-35)49(66)59-52-54(4,5)53(55(52,6)7)69-42-20-19-39(29-57)43(56)27-42/h8-12,15-20,25,27,33,36,40-41,44-45,48,52-53,64H,21-24,26,28,30-32H2,1-7H3,(H,58,67)(H,59,66)/t41-,44+,45+,48-,52-,53-/m1/s1","GDNAPEQOKLZKHJ-PHLGFMGRSA-N"
"363","P10275","AR","VHL","","ARD-266","CC1=NOC([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#CC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(Cl)=C5)C4(C)C)C=C3)CC2)C2=CC=CC=C2)C(C)C)=C1","0.5/1/0.2",">99/>95/>95","Degradation of AR in LNCaP/VCaP/22Rv1 cells after 6 h treatment","90/>95/>99","% AR degradation in LNCaP cells after 6 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2/6","Inhibit growth of LNCaP/VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01393","915.532","914.413375908","7.63","66","7","9","3","12","178.1","C52H59ClN6O7","InChI=1S/C52H59ClN6O7/c1-31(2)45(43-25-32(3)57-66-43)48(64)59-30-38(60)26-42(59)47(63)55-41(35-11-9-8-10-12-35)28-44(61)58-23-21-34(22-24-58)14-13-33-15-17-36(18-16-33)46(62)56-49-51(4,5)50(52(49,6)7)65-39-20-19-37(29-54)40(53)27-39/h8-12,15-20,25,27,31,34,38,41-42,45,49-50,60H,21-24,26,28,30H2,1-7H3,(H,55,63)(H,56,62)/t38-,41+,42+,45-,49-,50-/m1/s1","RTNONCBKGZNCJS-LJLQSONVSA-N"
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"378","Q00534","CDK6","CRBN","","CP-4","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCOCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","1004.119","1003.46643515","1.36","73","9","21","3","24","259.46","C50H61N13O10","InChI=1S/C50H61N13O10/c1-32-38-29-53-50(56-45(38)62(35-6-3-4-7-35)48(68)43(32)33(2)64)54-41-12-10-36(28-52-41)60-17-15-59(16-18-60)30-34-31-61(58-57-34)19-21-71-23-25-73-27-26-72-24-22-70-20-14-51-39-9-5-8-37-44(39)49(69)63(47(37)67)40-11-13-42(65)55-46(40)66/h5,8-10,12,28-29,31,35,40,51H,3-4,6-7,11,13-27,30H2,1-2H3,(H,55,65,66)(H,52,53,54,56)","XEWFMEFFNDGBRS-UHFFFAOYSA-N"
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"382","Q00534","CDK6","CRBN","","CP-10","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","2.1","","Degradation of CDK6 in U251 cells after 24 h treatment","","","262","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10/8","Inhibit proliferation of MM.1S/Mino cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","871.96","871.387790908","1.8","64","9","18","3","15","231.77","C44H49N13O7","InChI=1S/C44H49N13O7/c1-26-32-23-47-44(50-39(32)56(29-6-3-4-7-29)42(62)37(26)27(2)58)48-35-12-10-30(22-46-35)54-17-15-53(16-18-54)24-28-25-55(52-51-28)19-21-64-20-14-45-33-9-5-8-31-38(33)43(63)57(41(31)61)34-11-13-36(59)49-40(34)60/h5,8-10,12,22-23,25,29,34,45H,3-4,6-7,11,13-21,24H2,1-2H3,(H,49,59,60)(H,46,47,48,50)","PACRWHUPEPCFHX-UHFFFAOYSA-N"
"383","P11802","CDK4","CRBN","","CP-12","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","845.962","845.397292972","3.13","62","8","15","4","15","220.93","C44H51N11O7","InChI=1S/C44H51N11O7/c1-26-31-24-48-44(51-39(31)54(28-9-4-5-10-28)42(61)37(26)27(2)56)49-34-15-13-29(23-47-34)53-21-19-52(20-22-53)25-36(58)46-18-7-3-6-17-45-32-12-8-11-30-38(32)43(62)55(41(30)60)33-14-16-35(57)50-40(33)59/h8,11-13,15,23-24,28,33,45H,3-7,9-10,14,16-22,25H2,1-2H3,(H,46,58)(H,50,57,59)(H,47,48,49,51)","HQDYDPFMSXMKCW-UHFFFAOYSA-N"
"383","Q00534","CDK6","CRBN","","CP-12","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","845.962","845.397292972","3.13","62","8","15","4","15","220.93","C44H51N11O7","InChI=1S/C44H51N11O7/c1-26-31-24-48-44(51-39(31)54(28-9-4-5-10-28)42(61)37(26)27(2)56)49-34-15-13-29(23-47-34)53-21-19-52(20-22-53)25-36(58)46-18-7-3-6-17-45-32-12-8-11-30-38(32)43(62)55(41(30)60)33-14-16-35(57)50-40(33)59/h8,11-13,15,23-24,28,33,45H,3-7,9-10,14,16-22,25H2,1-2H3,(H,46,58)(H,50,57,59)(H,47,48,49,51)","HQDYDPFMSXMKCW-UHFFFAOYSA-N"
"384","P11802","CDK4","CRBN","","CP-13","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O",">100","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","869.988","869.408526352","3.02","64","9","17","3","15","222.54","C45H51N13O6","InChI=1S/C45H51N13O6/c1-27-33-24-48-45(51-40(33)57(30-9-4-5-10-30)43(63)38(27)28(2)59)49-36-15-13-31(23-47-36)55-21-19-54(20-22-55)25-29-26-56(53-52-29)18-7-3-6-17-46-34-12-8-11-32-39(34)44(64)58(42(32)62)35-14-16-37(60)50-41(35)61/h8,11-13,15,23-24,26,30,35,46H,3-7,9-10,14,16-22,25H2,1-2H3,(H,50,60,61)(H,47,48,49,51)","PEBAOKOWNDTABR-UHFFFAOYSA-N"
"384","Q00534","CDK6","CRBN","","CP-13","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","5.3","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","869.988","869.408526352","3.02","64","9","17","3","15","222.54","C45H51N13O6","InChI=1S/C45H51N13O6/c1-27-33-24-48-45(51-40(33)57(30-9-4-5-10-30)43(63)38(27)28(2)59)49-36-15-13-31(23-47-36)55-21-19-54(20-22-55)25-29-26-56(53-52-29)18-7-3-6-17-46-34-12-8-11-32-39(34)44(64)58(42(32)62)35-14-16-37(60)50-41(35)61/h8,11-13,15,23-24,26,30,35,46H,3-7,9-10,14,16-22,25H2,1-2H3,(H,50,60,61)(H,47,48,49,51)","PEBAOKOWNDTABR-UHFFFAOYSA-N"
"385","P11802","CDK4","CRBN","","CP-14","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O",">100","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","884.015","883.424176416","3.38","65","9","17","3","16","222.54","C46H53N13O6","InChI=1S/C46H53N13O6/c1-28-34-25-49-46(52-41(34)58(31-10-5-6-11-31)44(64)39(28)29(2)60)50-37-16-14-32(24-48-37)56-22-20-55(21-23-56)26-30-27-57(54-53-30)19-8-4-3-7-18-47-35-13-9-12-33-40(35)45(65)59(43(33)63)36-15-17-38(61)51-42(36)62/h9,12-14,16,24-25,27,31,36,47H,3-8,10-11,15,17-23,26H2,1-2H3,(H,51,61,62)(H,48,49,50,52)","VQBSDHOKKXEKJO-UHFFFAOYSA-N"
"385","Q00534","CDK6","CRBN","","CP-14","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","10.6","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","884.015","883.424176416","3.38","65","9","17","3","16","222.54","C46H53N13O6","InChI=1S/C46H53N13O6/c1-28-34-25-49-46(52-41(34)58(31-10-5-6-11-31)44(64)39(28)29(2)60)50-37-16-14-32(24-48-37)56-22-20-55(21-23-56)26-30-27-57(54-53-30)19-8-4-3-7-18-47-35-13-9-12-33-40(35)45(65)59(43(33)63)36-15-17-38(61)51-42(36)62/h9,12-14,16,24-25,27,31,36,47H,3-8,10-11,15,17-23,26H2,1-2H3,(H,51,61,62)(H,48,49,50,52)","VQBSDHOKKXEKJO-UHFFFAOYSA-N"
"386","P11802","CDK4","CRBN","","CP-15","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O",">50","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","834.935","834.38130856","2.42","61","8","16","3","16","210.29","C43H50N10O8","InChI=1S/C43H50N10O8/c1-26-31-25-46-43(49-38(31)52(28-6-3-4-7-28)41(58)36(26)27(2)54)47-34-12-10-29(24-45-34)51-17-15-50(16-18-51)19-21-61-23-22-60-20-14-44-32-9-5-8-30-37(32)42(59)53(40(30)57)33-11-13-35(55)48-39(33)56/h5,8-10,12,24-25,28,33,44H,3-4,6-7,11,13-23H2,1-2H3,(H,48,55,56)(H,45,46,47,49)","PKIMSAWOOAAVNA-UHFFFAOYSA-N"
"386","Q00534","CDK6","CRBN","","CP-15","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","1.6","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","834.935","834.38130856","2.42","61","8","16","3","16","210.29","C43H50N10O8","InChI=1S/C43H50N10O8/c1-26-31-25-46-43(49-38(31)52(28-6-3-4-7-28)41(58)36(26)27(2)54)47-34-12-10-29(24-45-34)51-17-15-50(16-18-51)19-21-61-23-22-60-20-14-44-32-9-5-8-30-37(32)42(59)53(40(30)57)33-11-13-35(55)48-39(33)56/h5,8-10,12,24-25,28,33,44H,3-4,6-7,11,13-23H2,1-2H3,(H,48,55,56)(H,45,46,47,49)","PKIMSAWOOAAVNA-UHFFFAOYSA-N"
"387","P11802","CDK4","CRBN","","CP-16","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCCC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O",">50","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","855.017","854.434012828","3.52","63","9","15","2","15","193.44","C46H54N12O5","InChI=1S/C46H54N12O5/c1-29-36-25-48-46(51-42(36)58(33-12-6-7-13-33)45(63)41(29)30(2)59)49-39-17-15-34(24-47-39)55-22-20-54(21-23-55)26-32-27-56(53-52-32)19-8-4-3-5-10-31-11-9-14-35-37(31)28-57(44(35)62)38-16-18-40(60)50-43(38)61/h9,11,14-15,17,24-25,27,33,38H,3-8,10,12-13,16,18-23,26,28H2,1-2H3,(H,50,60,61)(H,47,48,49,51)","YOIMKMXYGWEBJZ-UHFFFAOYSA-N"
"387","Q00534","CDK6","CRBN","","CP-16","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCCC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","1.7","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","855.017","854.434012828","3.52","63","9","15","2","15","193.44","C46H54N12O5","InChI=1S/C46H54N12O5/c1-29-36-25-48-46(51-42(36)58(33-12-6-7-13-33)45(63)41(29)30(2)59)49-39-17-15-34(24-47-39)55-22-20-54(21-23-55)26-32-27-56(53-52-32)19-8-4-3-5-10-31-11-9-14-35-37(31)28-57(44(35)62)38-16-18-40(60)50-43(38)61/h9,11,14-15,17,24-25,27,33,38H,3-8,10,12-13,16,18-23,26,28H2,1-2H3,(H,50,60,61)(H,47,48,49,51)","YOIMKMXYGWEBJZ-UHFFFAOYSA-N"
"388","P11802","CDK4","CRBN","","CP-17","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)C5=CN(CCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","885.943","885.367055464","1.72","65","9","18","3","14","248.84","C44H47N13O8","InChI=1S/C44H47N13O8/c1-25-30-23-47-44(50-38(30)56(27-6-3-4-7-27)42(63)36(25)26(2)58)48-34-12-10-28(22-46-34)53-15-17-54(18-16-53)41(62)32-24-55(52-51-32)19-21-65-20-14-45-31-9-5-8-29-37(31)43(64)57(40(29)61)33-11-13-35(59)49-39(33)60/h5,8-10,12,22-24,27,33,45H,3-4,6-7,11,13-21H2,1-2H3,(H,49,59,60)(H,46,47,48,50)","GOGLORWOXCCMGL-UHFFFAOYSA-N"
"388","Q00534","CDK6","CRBN","","CP-17","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)C5=CN(CCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","885.943","885.367055464","1.72","65","9","18","3","14","248.84","C44H47N13O8","InChI=1S/C44H47N13O8/c1-25-30-23-47-44(50-38(30)56(27-6-3-4-7-27)42(63)36(25)26(2)58)48-34-12-10-28(22-46-34)53-15-17-54(18-16-53)41(62)32-24-55(52-51-32)19-21-65-20-14-45-31-9-5-8-29-37(31)43(64)57(40(29)61)33-11-13-35(59)49-39(33)60/h5,8-10,12,22-24,27,33,45H,3-4,6-7,11,13-21H2,1-2H3,(H,49,59,60)(H,46,47,48,50)","GOGLORWOXCCMGL-UHFFFAOYSA-N"
"389","P11802","CDK4","CRBN","","CP-18","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CC5=CN(CCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","899.97","899.382705528","1.36","66","9","18","3","15","248.84","C45H49N13O8","InChI=1S/C45H49N13O8/c1-26-32-24-48-45(51-40(32)57(29-6-3-4-7-29)43(64)38(26)27(2)59)49-35-12-10-30(23-47-35)54-15-17-55(18-16-54)37(61)22-28-25-56(53-52-28)19-21-66-20-14-46-33-9-5-8-31-39(33)44(65)58(42(31)63)34-11-13-36(60)50-41(34)62/h5,8-10,12,23-25,29,34,46H,3-4,6-7,11,13-22H2,1-2H3,(H,50,60,62)(H,47,48,49,51)","DTCNCHRFNRETDL-UHFFFAOYSA-N"
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"397","P11802","CDK4","CRBN","","CP-A4","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CC6=CN(CCOCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C7CCC(=O)NC7=O)C8=O)N=N6)CC5)C=N4)=NC=C3F)C=C2N1C(C)C",">500","","Degradation of CDK4 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","1035.127","1034.46866132","2.55","75","9","20","3","25","238.21","C51H60F2N14O8","InChI=1S/C51H60F2N14O8/c1-32(2)66-33(3)57-47-38(52)25-35(26-42(47)66)46-39(53)28-56-51(60-46)58-43-9-7-34(27-55-43)29-63-12-14-64(15-13-63)30-36-31-65(62-61-36)16-18-73-20-22-75-24-23-74-21-19-72-17-11-54-40-6-4-5-37-45(40)50(71)67(49(37)70)41-8-10-44(68)59-48(41)69/h4-7,9,25-28,31-32,41,54H,8,10-24,29-30H2,1-3H3,(H,59,68,69)(H,55,56,58,60)","SXHHVSLMICYDHT-UHFFFAOYSA-N"
"397","Q00534","CDK6","CRBN","","CP-A4","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CC6=CN(CCOCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C7CCC(=O)NC7=O)C8=O)N=N6)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","145.5","","Degradation of CDK6 in U251 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","1035.127","1034.46866132","2.55","75","9","20","3","25","238.21","C51H60F2N14O8","InChI=1S/C51H60F2N14O8/c1-32(2)66-33(3)57-47-38(52)25-35(26-42(47)66)46-39(53)28-56-51(60-46)58-43-9-7-34(27-55-43)29-63-12-14-64(15-13-63)30-36-31-65(62-61-36)16-18-73-20-22-75-24-23-74-21-19-72-17-11-54-40-6-4-5-37-45(40)50(71)67(49(37)70)41-8-10-44(68)59-48(41)69/h4-7,9,25-28,31-32,41,54H,8,10-24,29-30H2,1-3H3,(H,59,68,69)(H,55,56,58,60)","SXHHVSLMICYDHT-UHFFFAOYSA-N"
"398","Q06187","BTK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","1146.325","1145.50674622","3.87","81","7","17","5","29","274.25","C57H73F2N9O12S","InChI=1S/C57H73F2N9O12S/c1-36-51(81-35-63-36)39-9-7-37(8-10-39)32-62-55(73)45-31-42(69)34-67(45)56(74)52(57(2,3)4)64-47(70)17-20-75-22-24-77-26-28-79-29-27-78-25-23-76-21-18-48(71)66-19-5-6-41(33-66)68-53(60)49(54(61)72)50(65-68)38-11-14-43(15-12-38)80-46-16-13-40(58)30-44(46)59/h7-16,30,35,41-42,45,52,69H,5-6,17-29,31-34,60H2,1-4H3,(H2,61,72)(H,62,73)(H,64,70)/t41-,42-,45+,52-/m1/s1","GIDOPMWSGRQBSU-CHYMOABDSA-N"
"399","Q06187","BTK","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","1190.378","1189.53296096","3.72","84","7","18","5","32","283.48","C59H77F2N9O13S","InChI=1S/C59H77F2N9O13S/c1-38-53(84-37-65-38)41-9-7-39(8-10-41)34-64-57(75)47-33-44(71)36-69(47)58(76)54(59(2,3)4)66-49(72)17-20-77-22-24-79-26-28-81-30-31-82-29-27-80-25-23-78-21-18-50(73)68-19-5-6-43(35-68)70-55(62)51(56(63)74)52(67-70)40-11-14-45(15-12-40)83-48-16-13-42(60)32-46(48)61/h7-16,32,37,43-44,47,54,71H,5-6,17-31,33-36,62H2,1-4H3,(H2,63,74)(H,64,75)(H,66,72)/t43-,44-,47+,54-/m1/s1","ABGCCJUHIVJXMA-NYHHYLLXSA-N"
"400","","BCR-ABL","VHL","","IMA-6-2-2-6-VHL","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","4.3/93","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1194.558","1193.64597974","7.59","86","8","16","5","32","225.6","C66H87N11O8S","InChI=1S/C66H87N11O8S/c1-47-16-25-54(40-57(47)73-65-68-28-26-56(72-65)53-14-13-27-67-43-53)71-62(80)52-23-19-50(20-24-52)44-76-32-30-75(31-33-76)29-10-6-7-11-34-83-36-38-85-39-37-84-35-12-8-9-15-59(79)74-61(66(3,4)5)64(82)77-45-55(78)41-58(77)63(81)69-42-49-17-21-51(22-18-49)60-48(2)70-46-86-60/h13-14,16-28,40,43,46,55,58,61,78H,6-12,15,29-39,41-42,44-45H2,1-5H3,(H,69,81)(H,71,80)(H,74,79)(H,68,72,73)/t55-,58+,61-/m1/s1","IOANWTPZMNOKPI-XNMZBHLMSA-N"
"401","","BCR-ABL","VHL","","IMA-6-2-2-VHL","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","5.8/98","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1094.397","1093.55716474","6.76","79","8","15","5","25","216.37","C60H75N11O7S","InChI=1S/C60H75N11O7S/c1-41-12-21-48(33-51(41)67-59-62-24-22-50(66-59)47-11-10-23-61-36-47)65-56(74)46-19-15-44(16-20-46)37-70-28-26-69(27-29-70)25-8-6-7-9-30-77-31-32-78-39-53(73)68-55(60(3,4)5)58(76)71-38-49(72)34-52(71)57(75)63-35-43-13-17-45(18-14-43)54-42(2)64-40-79-54/h10-24,33,36,40,49,52,55,72H,6-9,25-32,34-35,37-39H2,1-5H3,(H,63,75)(H,65,74)(H,68,73)(H,62,66,67)/t49-,52+,55-/m1/s1","ZOSUATBVNZFITI-LCJQEWRFSA-N"
"402","","BCR-ABL","VHL","","IMA-6-2-2-2-2-2-2-VHL","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","1.7/35","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1270.609","1269.66202373","6.17","91","8","19","5","37","253.29","C68H91N11O11S","InChI=1S/C68H91N11O11S/c1-49-12-21-56(41-59(49)75-67-70-24-22-58(74-67)55-11-10-23-69-44-55)73-64(82)54-19-15-52(16-20-54)45-78-28-26-77(27-29-78)25-8-6-7-9-30-85-31-32-86-33-34-87-35-36-88-37-38-89-39-40-90-47-61(81)76-63(68(3,4)5)66(84)79-46-57(80)42-60(79)65(83)71-43-51-13-17-53(18-14-51)62-50(2)72-48-91-62/h10-24,41,44,48,57,60,63,80H,6-9,25-40,42-43,45-47H2,1-5H3,(H,71,83)(H,73,82)(H,76,81)(H,70,74,75)/t57-,60+,63-/m1/s1","RMZHZNHVGWJZOM-HCUMQWPYSA-N"
"403","","BCR-ABL","VHL","","IMA-6-5-6-VHL","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","19/46","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1192.586","1191.66671519","8.81","86","8","15","5","32","216.37","C67H89N11O7S","InChI=1S/C67H89N11O7S/c1-48-19-28-55(41-58(48)74-66-69-31-29-57(73-66)54-17-16-30-68-44-54)72-63(81)53-26-22-51(23-27-53)45-77-35-33-76(34-36-77)32-11-6-7-12-37-84-39-14-9-15-40-85-38-13-8-10-18-60(80)75-62(67(3,4)5)65(83)78-46-56(79)42-59(78)64(82)70-43-50-20-24-52(25-21-50)61-49(2)71-47-86-61/h16-17,19-31,41,44,47,56,59,62,79H,6-15,18,32-40,42-43,45-46H2,1-5H3,(H,70,82)(H,72,81)(H,75,80)(H,69,73,74)/t56-,59+,62-/m1/s1","PSYCKWJHDVTQQR-FEFZYRSHSA-N"
"404","","BCR-ABL","CRBN","","IMA-6-2-2-6-CRBN","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCCOCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","6.2/110","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1037.232","1036.51707376","5.13","76","8","15","4","28","226.62","C57H68N10O9","InChI=1S/C57H68N10O9/c1-40-15-20-44(37-48(40)63-57-59-25-23-46(62-57)43-11-10-24-58-38-43)60-53(70)42-18-16-41(17-19-42)39-66-29-27-65(28-30-66)26-6-2-3-7-31-74-33-35-76-36-34-75-32-8-4-5-14-50(68)61-47-13-9-12-45-52(47)56(73)67(55(45)72)49-21-22-51(69)64-54(49)71/h9-13,15-20,23-25,37-38,49H,2-8,14,21-22,26-36,39H2,1H3,(H,60,70)(H,61,68)(H,59,62,63)(H,64,69,71)","WFGAGCUPXCZHIR-UHFFFAOYSA-N"
"405","","BCR-ABL","CRBN","","IMA-6-2-2-CRBN","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","4.7/72","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","937.071","936.428258752","4.31","69","8","14","4","21","217.39","C51H56N10O8","InChI=1S/C51H56N10O8/c1-34-11-16-38(30-42(34)57-51-53-21-19-40(56-51)37-8-7-20-52-31-37)54-47(64)36-14-12-35(13-15-36)32-60-25-23-59(24-26-60)22-4-2-3-5-27-68-28-29-69-33-45(63)55-41-10-6-9-39-46(41)50(67)61(49(39)66)43-17-18-44(62)58-48(43)65/h6-16,19-21,30-31,43H,2-5,17-18,22-29,32-33H2,1H3,(H,54,64)(H,55,63)(H,53,56,57)(H,58,62,65)","RDTYLMYTWSLYPI-UHFFFAOYSA-N"
"406","","BCR-ABL","CRBN","","IMA-6-2-2-2-2-2-2-CRBN","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","3.0/84","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1113.283","1112.53311774","3.72","81","8","18","4","33","254.31","C59H72N10O12","InChI=1S/C59H72N10O12/c1-42-11-16-46(38-50(42)65-59-61-21-19-48(64-59)45-8-7-20-60-39-45)62-55(72)44-14-12-43(13-15-44)40-68-25-23-67(24-26-68)22-4-2-3-5-27-76-28-29-77-30-31-78-32-33-79-34-35-80-36-37-81-41-53(71)63-49-10-6-9-47-54(49)58(75)69(57(47)74)51-17-18-52(70)66-56(51)73/h6-16,19-21,38-39,51H,2-5,17-18,22-37,40-41H2,1H3,(H,62,72)(H,63,71)(H,61,64,65)(H,66,70,73)","COXLKHXZOXQMJH-UHFFFAOYSA-N"
"407","","BCR-ABL","CRBN","","IMA-6-5-6-CRBN","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(CCCCCCOCCCCCOCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","N.D.","","","","","","","","24/360","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1035.26","1034.5378092","6.35","76","8","14","4","28","217.39","C58H70N10O8","InChI=1S/C58H70N10O8/c1-41-18-23-45(38-49(41)64-58-60-28-26-47(63-58)44-14-13-27-59-39-44)61-54(71)43-21-19-42(20-22-43)40-67-32-30-66(31-33-67)29-7-2-3-8-34-75-36-10-5-11-37-76-35-9-4-6-17-51(69)62-48-16-12-15-46-53(48)57(74)68(56(46)73)50-24-25-52(70)65-55(50)72/h12-16,18-23,26-28,38-39,50H,2-11,17,24-25,29-37,40H2,1H3,(H,61,71)(H,62,69)(H,60,63,64)(H,65,70,72)","WHNPOONKJUTFGG-UHFFFAOYSA-N"
"408","","BCR-ABL","VHL","","BOS-6-2-2-6-VHL","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","N.D.","","","","","","","","1.4/0.63","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1231.399","1229.55171628","9.45","85","7","17","4","34","222.2","C63H85Cl2N9O10S","InChI=1S/C63H85Cl2N9O10S/c1-43-59(85-42-69-43)45-18-16-44(17-19-45)39-68-61(77)53-33-47(75)41-74(53)62(78)60(63(2,3)4)71-57(76)15-10-9-13-27-82-30-32-83-31-29-81-26-12-8-7-11-20-72-22-24-73(25-23-72)21-14-28-84-56-36-51-48(34-55(56)80-6)58(46(38-66)40-67-51)70-52-37-54(79-5)50(65)35-49(52)64/h16-19,34-37,40,42,47,53,60,75H,7-15,20-33,39,41H2,1-6H3,(H,67,70)(H,68,77)(H,71,76)/t47-,53+,60-/m1/s1","CWVUETXKQKWPHY-GSKBGKSZSA-N"
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"410","","BCR-ABL","VHL","","BOS-6-2-2-2-2-2-2-VHL","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","N.D.","","","","","","","","0.57/0.3","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1307.45","1305.56776027","8.03","90","7","20","4","39","249.89","C65H89Cl2N9O13S","InChI=1S/C65H89Cl2N9O13S/c1-45-61(90-44-71-45)47-14-12-46(13-15-47)40-70-63(79)55-34-49(77)42-76(55)64(80)62(65(2,3)4)73-59(78)43-88-33-32-87-31-30-86-29-28-85-27-26-84-25-24-83-22-10-8-7-9-16-74-18-20-75(21-19-74)17-11-23-89-58-37-53-50(35-57(58)82-6)60(48(39-68)41-69-53)72-54-38-56(81-5)52(67)36-51(54)66/h12-15,35-38,41,44,49,55,62,77H,7-11,16-34,40,42-43H2,1-6H3,(H,69,72)(H,70,79)(H,73,78)/t49-,55+,62-/m1/s1","GNOXITMWGVMUID-AURWURAXSA-N"
"411","","BCR-ABL","VHL","","BOS-6-5-6-VHL","COC1=CC(NC2=C(C#N)C=NC3=CC(OCCCN4CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=C(OC)C=C23)=C(Cl)C=C1Cl","","N.D.","","","","","","","","4.6/1.5","Kd of non-phosphorylated/phosphorylated ABL was assessed by KINOMEscan Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201507634","1229.427","1227.57245172","10.67","85","7","16","4","34","212.97","C64H87Cl2N9O9S","InChI=1S/C64H87Cl2N9O9S/c1-44-60(85-43-70-44)46-21-19-45(20-22-46)40-69-62(78)54-34-48(76)42-75(54)63(79)61(64(2,3)4)72-58(77)18-11-9-14-30-83-32-16-10-15-31-82-29-13-8-7-12-23-73-25-27-74(28-26-73)24-17-33-84-57-37-52-49(35-56(57)81-6)59(47(39-67)41-68-52)71-53-38-55(80-5)51(66)36-50(53)65/h19-22,35-38,41,43,48,54,61,76H,7-18,23-34,40,42H2,1-6H3,(H,68,71)(H,69,78)(H,72,77)/t48-,54+,61-/m1/s1","YRWHPVXHAYVNFD-NVXUHPIISA-N"
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"414","Q00534","CDK6","MDM2","","MP-2","COC1=CC=C(C2=N[C@H](C3=CC=C(Cl)C=C3)[C@H](C3=CC=C(Cl)C=C3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCN3C=C(CN4CCN(C5=CC=C(NC6=NC=C7C(C)=C(C(C)=O)C(=O)N(C8CCCC8)C7=N6)N=C5)CC4)N=N3)C(=O)C2)C(OC(C)C)=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00871","1281.317","1279.52492434","5.72","91","11","20","2","24","249.2","C65H75Cl2N15O9","InChI=1S/C65H75Cl2N15O9/c1-41(2)91-54-34-51(88-5)19-20-52(54)61-72-59(44-10-14-46(66)15-11-44)60(45-12-16-47(67)17-13-45)82(61)65(87)79-28-27-78(57(85)40-79)39-56(84)68-22-30-89-32-33-90-31-29-80-38-48(74-75-80)37-76-23-25-77(26-24-76)50-18-21-55(69-35-50)71-64-70-36-53-42(3)58(43(4)83)63(86)81(62(53)73-64)49-8-6-7-9-49/h10-21,34-36,38,41,49,59-60H,6-9,22-33,37,39-40H2,1-5H3,(H,68,84)(H,69,70,71,73)/t59-,60+/m1/s1","OXXACNIEAZMKIQ-KHGQOBKHSA-N"
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"428","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)CCC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","91/96","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","100","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1245.245","1244.3583379","4.94","79","6","16","6","28","257.85","C55H70FIN8O12S2","InChI=1S/C55H70FIN8O12S2/c1-34-28-45(51(64(7)53(34)70)61-44-18-15-40(57)29-43(44)56)63-79(72,73)42-16-8-37(9-17-42)10-19-47(67)58-20-21-74-22-23-75-24-25-76-26-27-77-32-48(68)62-50(55(4,5)6)54(71)65-31-41(66)30-46(65)52(69)60-35(2)38-11-13-39(14-12-38)49-36(3)59-33-78-49/h8-9,11-18,28-29,33,35,41,46,50,61,63,66H,10,19-27,30-32H2,1-7H3,(H,58,67)(H,60,69)(H,62,68)/t35-,41+,46-,50+/m0/s1","CFVATUIJNACXGH-ULINFHPISA-N"
"428","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)CCC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1245.245","1244.3583379","4.94","79","6","16","6","28","257.85","C55H70FIN8O12S2","InChI=1S/C55H70FIN8O12S2/c1-34-28-45(51(64(7)53(34)70)61-44-18-15-40(57)29-43(44)56)63-79(72,73)42-16-8-37(9-17-42)10-19-47(67)58-20-21-74-22-23-75-24-25-76-26-27-77-32-48(68)62-50(55(4,5)6)54(71)65-31-41(66)30-46(65)52(69)60-35(2)38-11-13-39(14-12-38)49-36(3)59-33-78-49/h8-9,11-18,28-29,33,35,41,46,50,61,63,66H,10,19-27,30-32H2,1-7H3,(H,58,67)(H,60,69)(H,62,68)/t35-,41+,46-,50+/m0/s1","CFVATUIJNACXGH-ULINFHPISA-N"
"429","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","72/95","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","158","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1203.164","1202.31138771","4.9","76","6","16","6","25","257.85","C52H64FIN8O12S2","InChI=1S/C52H64FIN8O12S2/c1-31-24-42(48(61(7)50(31)67)58-41-17-12-36(54)25-40(41)53)60-76(69,70)39-15-13-38(14-16-39)74-29-44(64)55-18-19-71-20-21-72-22-23-73-28-45(65)59-47(52(4,5)6)51(68)62-27-37(63)26-43(62)49(66)57-32(2)34-8-10-35(11-9-34)46-33(3)56-30-75-46/h8-17,24-25,30,32,37,43,47,58,60,63H,18-23,26-29H2,1-7H3,(H,55,64)(H,57,66)(H,59,65)/t32-,37+,43-,47+/m0/s1","RGOBXIIESQAMMF-NZSHAYRGSA-N"
"429","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)COC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1203.164","1202.31138771","4.9","76","6","16","6","25","257.85","C52H64FIN8O12S2","InChI=1S/C52H64FIN8O12S2/c1-31-24-42(48(61(7)50(31)67)58-41-17-12-36(54)25-40(41)53)60-76(69,70)39-15-13-38(14-16-39)74-29-44(64)55-18-19-71-20-21-72-22-23-73-28-45(65)59-47(52(4,5)6)51(68)62-27-37(63)26-43(62)49(66)57-32(2)34-8-10-35(11-9-34)46-33(3)56-30-75-46/h8-17,24-25,30,32,37,43,47,58,60,63H,18-23,26-29H2,1-7H3,(H,55,64)(H,57,66)(H,59,65)/t32-,37+,43-,47+/m0/s1","RGOBXIIESQAMMF-NZSHAYRGSA-N"
"430","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)COC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","77/96","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","158","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1247.217","1246.33760246","4.75","79","6","17","6","28","267.08","C54H68FIN8O13S2","InChI=1S/C54H68FIN8O13S2/c1-33-26-44(50(63(7)52(33)69)60-43-17-12-38(56)27-42(43)55)62-79(71,72)41-15-13-40(14-16-41)77-31-46(66)57-18-19-73-20-21-74-22-23-75-24-25-76-30-47(67)61-49(54(4,5)6)53(70)64-29-39(65)28-45(64)51(68)59-34(2)36-8-10-37(11-9-36)48-35(3)58-32-78-48/h8-17,26-27,32,34,39,45,49,60,62,65H,18-25,28-31H2,1-7H3,(H,57,66)(H,59,68)(H,61,67)/t34-,39+,45-,49+/m0/s1","NOQOJFNUXOWBES-OGCYYVDUSA-N"
"431","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","47/94","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","5012","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1173.138","1172.30082302","4.86","74","6","15","6","23","248.62","C51H62FIN8O11S2","InChI=1S/C51H62FIN8O11S2/c1-30-24-41(46(60(7)49(30)66)57-40-17-14-36(53)25-39(40)52)59-74(68,69)38-15-12-35(13-16-38)47(64)54-18-19-70-20-21-71-22-23-72-28-43(63)58-45(51(4,5)6)50(67)61-27-37(62)26-42(61)48(65)56-31(2)33-8-10-34(11-9-33)44-32(3)55-29-73-44/h8-17,24-25,29,31,37,42,45,57,59,62H,18-23,26-28H2,1-7H3,(H,54,64)(H,56,65)(H,58,63)/t31-,37+,42-,45+/m0/s1","GIJPSQBRNWHRSC-FDPDJWOESA-N"
"432","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","46/97","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","1259","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1217.191","1216.32703777","4.71","77","6","16","6","26","257.85","C53H66FIN8O12S2","InChI=1S/C53H66FIN8O12S2/c1-32-26-43(48(62(7)51(32)68)59-42-17-14-38(55)27-41(42)54)61-77(70,71)40-15-12-37(13-16-40)49(66)56-18-19-72-20-21-73-22-23-74-24-25-75-30-45(65)60-47(53(4,5)6)52(69)63-29-39(64)28-44(63)50(67)58-33(2)35-8-10-36(11-9-35)46-34(3)57-31-76-46/h8-17,26-27,31,33,39,44,47,59,61,64H,18-25,28-30H2,1-7H3,(H,56,66)(H,58,67)(H,60,65)/t33-,39+,44-,47+/m0/s1","LSYHJWVDQGMSJD-BSAWYQFCSA-N"
"433","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNCC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","18/48","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","10000","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1159.155","1158.32155847","4.95","73","6","15","6","24","231.55","C51H64FIN8O10S2","InChI=1S/C51H64FIN8O10S2/c1-31-24-42(47(60(7)49(31)65)57-41-17-14-37(53)25-40(41)52)59-73(67,68)39-15-8-34(9-16-39)27-54-18-19-69-20-21-70-22-23-71-29-44(63)58-46(51(4,5)6)50(66)61-28-38(62)26-43(61)48(64)56-32(2)35-10-12-36(13-11-35)45-33(3)55-30-72-45/h8-17,24-25,30,32,38,43,46,54,57,59,62H,18-23,26-29H2,1-7H3,(H,56,64)(H,58,63)/t32-,38+,43-,46+/m0/s1","NWQHSYBBUCWBPX-XYUQTDPKSA-N"
"434","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNCC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","35/48","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","10000","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1203.208","1202.34777322","4.8","76","6","16","6","27","240.78","C53H68FIN8O11S2","InChI=1S/C53H68FIN8O11S2/c1-33-26-44(49(62(7)51(33)67)59-43-17-14-39(55)27-42(43)54)61-76(69,70)41-15-8-36(9-16-41)29-56-18-19-71-20-21-72-22-23-73-24-25-74-31-46(65)60-48(53(4,5)6)52(68)63-30-40(64)28-45(63)50(66)58-34(2)37-10-12-38(13-11-37)47-35(3)57-32-75-47/h8-17,26-27,32,34,40,45,48,56,59,61,64H,18-25,28-31H2,1-7H3,(H,58,66)(H,60,65)/t34-,40+,45-,48+/m0/s1","CCRSFZWLRCDCKR-OSOZMEPSSA-N"
"435","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)CC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","67/91","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1187.165","1186.31647309","4.79","75","6","15","6","24","248.62","C52H64FIN8O11S2","InChI=1S/C52H64FIN8O11S2/c1-31-24-42(48(61(7)50(31)67)58-41-17-14-37(54)26-40(41)53)60-75(69,70)39-15-8-34(9-16-39)25-44(64)55-18-19-71-20-21-72-22-23-73-29-45(65)59-47(52(4,5)6)51(68)62-28-38(63)27-43(62)49(66)57-32(2)35-10-12-36(13-11-35)46-33(3)56-30-74-46/h8-17,24,26,30,32,38,43,47,58,60,63H,18-23,25,27-29H2,1-7H3,(H,55,64)(H,57,66)(H,59,65)/t32-,38+,43-,47+/m0/s1","ZTMWSRAWOOFGPY-LOLWDDHHSA-N"
"436","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)CC3=CC=C(S(=O)(=O)NC4=C(NC5=CC=C(I)C=C5F)N(C)C(=O)C(C)=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","87/96","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","251","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1231.218","1230.34268784","4.65","78","6","16","6","27","257.85","C54H68FIN8O12S2","InChI=1S/C54H68FIN8O12S2/c1-33-26-44(50(63(7)52(33)69)60-43-17-14-39(56)28-42(43)55)62-78(71,72)41-15-8-36(9-16-41)27-46(66)57-18-19-73-20-21-74-22-23-75-24-25-76-31-47(67)61-49(54(4,5)6)53(70)64-30-40(65)29-45(64)51(68)59-34(2)37-10-12-38(13-11-37)48-35(3)58-32-77-48/h8-17,26,28,32,34,40,45,49,60,62,65H,18-25,27,29-31H2,1-7H3,(H,57,66)(H,59,68)(H,61,67)/t34-,40+,45-,49+/m0/s1","GTLONGWELMFATG-AULUSFAHSA-N"
"437","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(C(=O)NCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","16/39","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","3981","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","987.802","987.177002416","1.5","62","6","13","5","19","232.57","C41H43FIN7O11S","InChI=1S/C41H43FIN7O11S/c1-24-20-33(37(49(2)40(24)55)46-32-11-8-26(43)21-30(32)42)48-62(57,58)27-9-6-25(7-10-27)38(53)44-14-15-59-16-17-60-18-19-61-23-36(52)45-31-5-3-4-28-29(31)22-50(41(28)56)34-12-13-35(51)47-39(34)54/h3-11,20-21,34,46,48H,12-19,22-23H2,1-2H3,(H,44,53)(H,45,52)(H,47,51,54)","DMUXBDQIXCMTOC-UHFFFAOYSA-N"
"438","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","29/47","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","6310","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1031.855","1031.20321716","1.36","65","6","14","5","22","241.8","C43H47FIN7O12S","InChI=1S/C43H47FIN7O12S/c1-26-22-35(39(51(2)42(26)57)48-34-11-8-28(45)23-32(34)44)50-65(59,60)29-9-6-27(7-10-29)40(55)46-14-15-61-16-17-62-18-19-63-20-21-64-25-38(54)47-33-5-3-4-30-31(33)24-52(43(30)58)36-12-13-37(53)49-41(36)56/h3-11,22-23,36,48,50H,12-21,24-25H2,1-2H3,(H,46,55)(H,47,54)(H,49,53,56)","LUOUZPCXWAUQNN-UHFFFAOYSA-N"
"439","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CNCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","3/38","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","5012","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","973.819","973.19773786","1.59","61","6","13","5","20","215.5","C41H45FIN7O10S","InChI=1S/C41H45FIN7O10S/c1-25-20-34(38(49(2)40(25)54)46-33-11-8-27(43)21-31(33)42)48-61(56,57)28-9-6-26(7-10-28)22-44-14-15-58-16-17-59-18-19-60-24-37(52)45-32-5-3-4-29-30(32)23-50(41(29)55)35-12-13-36(51)47-39(35)53/h3-11,20-21,35,44,46,48H,12-19,22-24H2,1-2H3,(H,45,52)(H,47,51,53)","DHGPMRONPFFHPD-UHFFFAOYSA-N"
"440","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CNCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","5/57","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1017.872","1017.22395261","1.45","64","6","14","5","23","224.73","C43H49FIN7O11S","InChI=1S/C43H49FIN7O11S/c1-27-22-36(40(51(2)42(27)56)48-35-11-8-29(45)23-33(35)44)50-64(58,59)30-9-6-28(7-10-30)24-46-14-15-60-16-17-61-18-19-62-20-21-63-26-39(54)47-34-5-3-4-31-32(34)25-52(43(31)57)37-12-13-38(53)49-41(37)55/h3-11,22-23,37,46,48,50H,12-21,24-26H2,1-2H3,(H,47,54)(H,49,53,55)","PFNBTGCZGLGIOJ-UHFFFAOYSA-N"
"441","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CC(=O)NCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","30/65","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1001.829","1001.19265248","1.44","63","6","13","5","20","232.57","C42H45FIN7O11S","InChI=1S/C42H45FIN7O11S/c1-25-20-34(39(50(2)41(25)56)47-33-11-8-27(44)22-31(33)43)49-63(58,59)28-9-6-26(7-10-28)21-37(53)45-14-15-60-16-17-61-18-19-62-24-38(54)46-32-5-3-4-29-30(32)23-51(42(29)57)35-12-13-36(52)48-40(35)55/h3-11,20,22,35,47,49H,12-19,21,23-24H2,1-2H3,(H,45,53)(H,46,54)(H,48,52,55)","NUNFHWWEFPQERE-UHFFFAOYSA-N"
"442","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CC(=O)NCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","23/86","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","316","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1045.882","1045.21886723","1.29","66","6","14","5","23","241.8","C44H49FIN7O12S","InChI=1S/C44H49FIN7O12S/c1-27-22-36(41(52(2)43(27)58)49-35-11-8-29(46)24-33(35)45)51-66(60,61)30-9-6-28(7-10-30)23-39(55)47-14-15-62-16-17-63-18-19-64-20-21-65-26-40(56)48-34-5-3-4-31-32(34)25-53(44(31)59)37-12-13-38(54)50-42(37)57/h3-11,22,24,37,49,51H,12-21,23,25-26H2,1-2H3,(H,47,55)(H,48,56)(H,50,54,57)","OSRMXKDMZRNHJD-UHFFFAOYSA-N"
"443","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CCC(=O)NCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","8/57","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1015.856","1015.20830254","1.73","64","6","13","5","21","232.57","C43H47FIN7O11S","InChI=1S/C43H47FIN7O11S/c1-26-22-35(40(51(2)42(26)57)48-34-12-9-28(45)23-32(34)44)50-64(59,60)29-10-6-27(7-11-29)8-14-37(53)46-16-17-61-18-19-62-20-21-63-25-39(55)47-33-5-3-4-30-31(33)24-52(43(30)58)36-13-15-38(54)49-41(36)56/h3-7,9-12,22-23,36,48,50H,8,13-21,24-25H2,1-2H3,(H,46,53)(H,47,55)(H,49,54,56)","DWKIJYGOWOLTFN-UHFFFAOYSA-N"
"444","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CCC(=O)NCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","33/87","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","126","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1059.909","1059.23451729","1.59","67","6","14","5","24","241.8","C45H51FIN7O12S","InChI=1S/C45H51FIN7O12S/c1-28-24-37(42(53(2)44(28)59)50-36-12-9-30(47)25-34(36)46)52-67(61,62)31-10-6-29(7-11-31)8-14-39(55)48-16-17-63-18-19-64-20-21-65-22-23-66-27-41(57)49-35-5-3-4-32-33(35)26-54(45(32)60)38-13-15-40(56)51-43(38)58/h3-7,9-12,24-25,38,50,52H,8,13-23,26-27H2,1-2H3,(H,48,55)(H,49,57)(H,51,56,58)","WHKVOEUMNVGRRD-UHFFFAOYSA-N"
"445","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(OCC(=O)NCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","41/88","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","200","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1017.828","1017.1875671","1.54","64","6","14","5","21","241.8","C42H45FIN7O12S","InChI=1S/C42H45FIN7O12S/c1-25-20-34(39(50(2)41(25)56)47-33-11-6-26(44)21-31(33)43)49-64(58,59)28-9-7-27(8-10-28)63-24-37(53)45-14-15-60-16-17-61-18-19-62-23-38(54)46-32-5-3-4-29-30(32)22-51(42(29)57)35-12-13-36(52)48-40(35)55/h3-11,20-21,35,47,49H,12-19,22-24H2,1-2H3,(H,45,53)(H,46,54)(H,48,52,55)","RKBYTQATEIXQSV-UHFFFAOYSA-N"
"446","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(OCC(=O)NCCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","28/65","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","316","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1061.881","1061.21378185","1.39","67","6","15","5","24","251.03","C44H49FIN7O13S","InChI=1S/C44H49FIN7O13S/c1-27-22-36(41(52(2)43(27)58)49-35-11-6-28(46)23-33(35)45)51-67(60,61)30-9-7-29(8-10-30)66-26-39(55)47-14-15-62-16-17-63-18-19-64-20-21-65-25-40(56)48-34-5-3-4-31-32(34)24-53(44(31)59)37-12-13-38(54)50-42(37)57/h3-11,22-23,37,49,51H,12-21,24-26H2,1-2H3,(H,47,55)(H,48,56)(H,50,54,57)","NMPUXRVLXNMLLX-UHFFFAOYSA-N"
"447","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(C(=O)NCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","45/47","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","10000","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","988.786","988.161018004","2.21","62","6","14","4","20","229.77","C41H42FIN6O12S","InChI=1S/C41H42FIN6O12S/c1-24-22-31(36(48(2)39(24)53)45-30-11-8-26(43)23-29(30)42)47-62(56,57)27-9-6-25(7-10-27)37(51)44-14-15-58-16-17-59-18-19-60-20-21-61-33-5-3-4-28-35(33)41(55)49(40(28)54)32-12-13-34(50)46-38(32)52/h3-11,22-23,32,45,47H,12-21H2,1-2H3,(H,44,51)(H,46,50,52)","BAXMOHKQMFWZCR-UHFFFAOYSA-N"
"448","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(C(=O)NCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","16/87","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","1000","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1076.892","1076.2134475","1.92","68","6","16","4","26","248.23","C45H50FIN6O14S","InChI=1S/C45H50FIN6O14S/c1-28-26-35(40(52(2)43(28)57)49-34-11-8-30(47)27-33(34)46)51-68(60,61)31-9-6-29(7-10-31)41(55)48-14-15-62-16-17-63-18-19-64-20-21-65-22-23-66-24-25-67-37-5-3-4-32-39(37)45(59)53(44(32)58)36-12-13-38(54)50-42(36)56/h3-11,26-27,36,49,51H,12-25H2,1-2H3,(H,48,55)(H,50,54,56)","QXXWLINRPYYMTR-UHFFFAOYSA-N"
"449","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CNCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","57/93","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","794","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1062.909","1062.23418294","2.01","67","6","16","4","27","231.16","C45H52FIN6O13S","InChI=1S/C45H52FIN6O13S/c1-29-26-36(41(52(2)43(29)56)49-35-11-8-31(47)27-34(35)46)51-67(59,60)32-9-6-30(7-10-32)28-48-14-15-61-16-17-62-18-19-63-20-21-64-22-23-65-24-25-66-38-5-3-4-33-40(38)45(58)53(44(33)57)37-12-13-39(54)50-42(37)55/h3-11,26-27,37,48-49,51H,12-25,28H2,1-2H3,(H,50,54,55)","MWLQASKAZQGHIT-UHFFFAOYSA-N"
"450","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CNCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","14/29","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","1000","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","974.803","974.181753448","2.3","61","6","14","4","21","212.7","C41H44FIN6O11S","InChI=1S/C41H44FIN6O11S/c1-25-22-32(37(48(2)39(25)52)45-31-11-8-27(43)23-30(31)42)47-61(55,56)28-9-6-26(7-10-28)24-44-14-15-57-16-17-58-18-19-59-20-21-60-34-5-3-4-29-36(34)41(54)49(40(29)53)33-12-13-35(50)46-38(33)51/h3-11,22-23,33,44-45,47H,12-21,24H2,1-2H3,(H,46,50,51)","WSBDYORNLHWNFP-UHFFFAOYSA-N"
"451","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CC(=O)NCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","30/81","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1002.813","1002.17666807","2.15","63","6","14","4","21","229.77","C42H44FIN6O12S","InChI=1S/C42H44FIN6O12S/c1-25-22-32(38(49(2)40(25)54)46-31-11-8-27(44)24-30(31)43)48-63(57,58)28-9-6-26(7-10-28)23-36(52)45-14-15-59-16-17-60-18-19-61-20-21-62-34-5-3-4-29-37(34)42(56)50(41(29)55)33-12-13-35(51)47-39(33)53/h3-11,22,24,33,46,48H,12-21,23H2,1-2H3,(H,45,52)(H,47,51,53)","MIRIMGIZVLPPPX-UHFFFAOYSA-N"
"452","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CC(=O)NCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","18/89","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1090.919","1090.22909756","1.85","69","6","16","4","27","248.23","C46H52FIN6O14S","InChI=1S/C46H52FIN6O14S/c1-29-26-36(42(53(2)44(29)58)50-35-11-8-31(48)28-34(35)47)52-69(61,62)32-9-6-30(7-10-32)27-40(56)49-14-15-63-16-17-64-18-19-65-20-21-66-22-23-67-24-25-68-38-5-3-4-33-41(38)46(60)54(45(33)59)37-12-13-39(55)51-43(37)57/h3-11,26,28,37,50,52H,12-25,27H2,1-2H3,(H,49,56)(H,51,55,57)","DXOCBPZWESIGJA-UHFFFAOYSA-N"
"453","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CCC(=O)NCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","42/94","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","631","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1016.84","1016.19231813","2.44","64","6","14","4","22","229.77","C43H46FIN6O12S","InChI=1S/C43H46FIN6O12S/c1-26-24-33(39(50(2)41(26)55)47-32-12-9-28(45)25-31(32)44)49-64(58,59)29-10-6-27(7-11-29)8-14-36(52)46-16-17-60-18-19-61-20-21-62-22-23-63-35-5-3-4-30-38(35)43(57)51(42(30)56)34-13-15-37(53)48-40(34)54/h3-7,9-12,24-25,34,47,49H,8,13-23H2,1-2H3,(H,46,52)(H,48,53,54)","YXJRCIKHUGKXFX-UHFFFAOYSA-N"
"454","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(CCC(=O)NCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","24/90","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","100","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1104.946","1104.24474763","2.15","70","6","16","4","28","248.23","C47H54FIN6O14S","InChI=1S/C47H54FIN6O14S/c1-30-28-37(43(54(2)45(30)59)51-36-12-9-32(49)29-35(36)48)53-70(62,63)33-10-6-31(7-11-33)8-14-40(56)50-16-17-64-18-19-65-20-21-66-22-23-67-24-25-68-26-27-69-39-5-3-4-34-42(39)47(61)55(46(34)60)38-13-15-41(57)52-44(38)58/h3-7,9-12,28-29,38,51,53H,8,13-27H2,1-2H3,(H,50,56)(H,52,57,58)","PMUKFZPFINZXJQ-UHFFFAOYSA-N"
"455","Q02750","MEK1","CRBN","","","CC1=CC(NS(=O)(=O)C2=CC=C(OCC(=O)NCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)=C(NC2=CC=C(I)C=C2F)N(C)C1=O","","","","55/96","% MEK1 degradation in A375 cells after 16 h treatment at 1000/10000 nM","200","Inhibition of MEK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00810","1106.918","1106.22401218","1.96","70","6","17","4","28","257.46","C46H52FIN6O15S","InChI=1S/C46H52FIN6O15S/c1-29-26-36(42(53(2)44(29)58)50-35-11-6-30(48)27-34(35)47)52-70(61,62)32-9-7-31(8-10-32)69-28-40(56)49-14-15-63-16-17-64-18-19-65-20-21-66-22-23-67-24-25-68-38-5-3-4-33-41(38)46(60)54(45(33)59)37-12-13-39(55)51-43(37)57/h3-11,26-27,37,50,52H,12-25,28H2,1-2H3,(H,49,56)(H,51,55,57)","IRDUBSANLBYJIO-UHFFFAOYSA-N"
"456","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14.9","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1172.917","1171.51139276","7.38","81","7","17","5","29","242.67","C58H78ClN11O9S2","InChI=1S/C58H78ClN11O9S2/c1-38-14-13-15-44(59)51(38)67-55(75)46-35-61-57(81-46)65-47-33-48(64-40(3)63-47)68-22-24-69(25-23-68)50(73)17-10-8-12-27-78-29-31-79-30-28-77-26-11-7-9-16-49(72)66-53(58(4,5)6)56(76)70-36-43(71)32-45(70)54(74)60-34-41-18-20-42(21-19-41)52-39(2)62-37-80-52/h13-15,18-21,33,35,37,43,45,53,71H,7-12,16-17,22-32,34,36H2,1-6H3,(H,60,74)(H,66,72)(H,67,75)(H,61,63,64,65)/t43-,45+,53-/m1/s1","HDJLEUZTOSGRLD-YFUJKFBNSA-N"
"457","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1610","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1176.861","1175.46992187","4.94","81","7","19","5","29","261.13","C56H74ClN11O11S2","InChI=1S/C56H74ClN11O11S2/c1-36-8-7-9-42(57)49(36)65-53(73)44-33-59-55(81-44)63-45-31-46(62-38(3)61-45)66-16-18-67(19-17-66)48(71)15-21-76-23-25-78-27-29-79-28-26-77-24-22-75-20-14-47(70)64-51(56(4,5)6)54(74)68-34-41(69)30-43(68)52(72)58-32-39-10-12-40(13-11-39)50-37(2)60-35-80-50/h7-13,31,33,35,41,43,51,69H,14-30,32,34H2,1-6H3,(H,58,72)(H,64,70)(H,65,73)(H,59,61,62,63)/t41-,43+,51-/m1/s1","CMFLUHWDZWPDGE-IFBJVNMJSA-N"
"458","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2160","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1132.808","1131.44370712","5.09","78","7","18","5","26","251.9","C54H70ClN11O10S2","InChI=1S/C54H70ClN11O10S2/c1-34-8-7-9-40(55)47(34)63-51(71)42-31-57-53(78-42)61-43-29-44(60-36(3)59-43)64-16-18-65(19-17-64)46(69)15-21-74-23-25-76-27-26-75-24-22-73-20-14-45(68)62-49(54(4,5)6)52(72)66-32-39(67)28-41(66)50(70)56-30-37-10-12-38(13-11-37)48-35(2)58-33-77-48/h7-13,29,31,33,39,41,49,67H,14-28,30,32H2,1-6H3,(H,56,70)(H,62,68)(H,63,71)(H,57,59,60,61)/t39-,41+,49-/m1/s1","HKFFZDJTHXGGQO-OANIXJOXSA-N"
"459","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3430","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1088.755","1087.41749237","5.24","75","7","17","5","23","242.67","C52H66ClN11O9S2","InChI=1S/C52H66ClN11O9S2/c1-32-8-7-9-38(53)45(32)61-49(69)40-29-55-51(75-40)59-41-27-42(58-34(3)57-41)62-16-18-63(19-17-62)44(67)15-21-72-23-25-73-24-22-71-20-14-43(66)60-47(52(4,5)6)50(70)64-30-37(65)26-39(64)48(68)54-28-35-10-12-36(13-11-35)46-33(2)56-31-74-46/h7-13,27,29,31,37,39,47,65H,14-26,28,30H2,1-6H3,(H,54,68)(H,60,66)(H,61,69)(H,55,57,58,59)/t37-,39+,47-/m1/s1","LLVDKMUZHRCMGB-PHQHQIPESA-N"
"460","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","670","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1044.702","1043.39127762","5.39","72","7","16","5","20","233.44","C50H62ClN11O8S2","InChI=1S/C50H62ClN11O8S2/c1-30-8-7-9-36(51)43(30)59-47(67)38-27-53-49(72-38)57-39-25-40(56-32(3)55-39)60-16-18-61(19-17-60)42(65)15-21-70-23-22-69-20-14-41(64)58-45(50(4,5)6)48(68)62-28-35(63)24-37(62)46(66)52-26-33-10-12-34(13-11-33)44-31(2)54-29-71-44/h7-13,25,27,29,35,37,45,63H,14-24,26,28H2,1-6H3,(H,52,66)(H,58,64)(H,59,67)(H,53,55,56,57)/t35-,37+,45-/m1/s1","SMMZCSGLGVHUAE-ZIBKGDFVSA-N"
"461","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)COCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2240","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1016.648","1015.3599775","5.58","70","7","16","5","18","233.44","C48H58ClN11O8S2","InChI=1S/C48H58ClN11O8S2/c1-28-8-7-9-34(49)41(28)57-45(65)36-23-51-47(70-36)55-37-21-38(54-30(3)53-37)58-14-16-59(17-15-58)40(63)26-68-19-18-67-25-39(62)56-43(48(4,5)6)46(66)60-24-33(61)20-35(60)44(64)50-22-31-10-12-32(13-11-31)42-29(2)52-27-69-42/h7-13,21,23,27,33,35,43,61H,14-20,22,24-26H2,1-6H3,(H,50,64)(H,56,62)(H,57,65)(H,51,53,54,55)/t33-,35+,43-/m1/s1","KEFFYERPTJVDSQ-MXYPERTFSA-N"
"462","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.3","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1124.92","1123.5266489","11.81","78","7","14","5","26","214.98","C58H78ClN11O6S2","InChI=1S/C58H78ClN11O6S2/c1-38-20-19-21-44(59)51(38)67-55(75)46-35-61-57(78-46)65-47-33-48(64-40(3)63-47)68-28-30-69(31-29-68)50(73)23-18-16-14-12-10-8-7-9-11-13-15-17-22-49(72)66-53(58(4,5)6)56(76)70-36-43(71)32-45(70)54(74)60-34-41-24-26-42(27-25-41)52-39(2)62-37-77-52/h19-21,24-27,33,35,37,43,45,53,71H,7-18,22-23,28-32,34,36H2,1-6H3,(H,60,74)(H,66,72)(H,67,75)(H,61,63,64,65)/t43-,45+,53-/m1/s1","IVNSCXIEGGKQDA-YFUJKFBNSA-N"
"463","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14.4","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1096.866","1095.49534877","10.73","76","7","14","5","24","214.98","C56H74ClN11O6S2","InChI=1S/C56H74ClN11O6S2/c1-36-18-17-19-42(57)49(36)65-53(73)44-33-59-55(76-44)63-45-31-46(62-38(3)61-45)66-26-28-67(29-27-66)48(71)21-16-14-12-10-8-7-9-11-13-15-20-47(70)64-51(56(4,5)6)54(74)68-34-41(69)30-43(68)52(72)58-32-39-22-24-40(25-23-39)50-37(2)60-35-75-50/h17-19,22-25,31,33,35,41,43,51,69H,7-16,20-21,26-30,32,34H2,1-6H3,(H,58,72)(H,64,70)(H,65,73)(H,59,61,62,63)/t41-,43+,51-/m1/s1","YOWOOSQYMMTHBE-IFBJVNMJSA-N"
"464","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","10.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14.3","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1040.758","1039.43274851","8.56","72","7","14","5","20","214.98","C52H66ClN11O6S2","InChI=1S/C52H66ClN11O6S2/c1-32-14-13-15-38(53)45(32)61-49(69)40-29-55-51(72-40)59-41-27-42(58-34(3)57-41)62-22-24-63(25-23-62)44(67)17-12-10-8-7-9-11-16-43(66)60-47(52(4,5)6)50(70)64-30-37(65)26-39(64)48(68)54-28-35-18-20-36(21-19-35)46-33(2)56-31-71-46/h13-15,18-21,27,29,31,37,39,47,65H,7-12,16-17,22-26,28,30H2,1-6H3,(H,54,68)(H,60,66)(H,61,69)(H,55,57,58,59)/t37-,39+,47-/m1/s1","WATFMEVRKAKIPO-PHQHQIPESA-N"
"465","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","37.9","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22.4","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1026.731","1025.41709845","8.02","71","7","14","5","19","214.98","C51H64ClN11O6S2","InChI=1S/C51H64ClN11O6S2/c1-31-13-12-14-37(52)44(31)60-48(68)39-28-54-50(71-39)58-40-26-41(57-33(3)56-40)61-21-23-62(24-22-61)43(66)16-11-9-7-8-10-15-42(65)59-46(51(4,5)6)49(69)63-29-36(64)25-38(63)47(67)53-27-34-17-19-35(20-18-34)45-32(2)55-30-70-45/h12-14,17-20,26,28,30,36,38,46,64H,7-11,15-16,21-25,27,29H2,1-6H3,(H,53,67)(H,59,65)(H,60,68)(H,54,56,57,58)/t36-,38+,46-/m1/s1","JHGSGIUENJDREJ-TZAPCMPKSA-N"
"466","","BCR-ABL","VHL","","SIAIS178","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","8.5","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","0.35/0.14","Kd of non-phosphorylated/phosphorylated c-ABL was tested using the KinomeScan platform","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24","Inhibit growth of K562 cells","","","","","","","","","","","0.02","Compounds were administered at 10000 nM and incubated for 2 h","0.07","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acs.jmedchem.9b01264","1012.704","1011.40144838","7.48","70","7","14","5","18","214.98","C50H62ClN11O6S2","InChI=1S/C50H62ClN11O6S2/c1-30-12-11-13-36(51)43(30)59-47(67)38-27-53-49(70-38)57-39-25-40(56-32(3)55-39)60-20-22-61(23-21-60)42(65)15-10-8-7-9-14-41(64)58-45(50(4,5)6)48(68)62-28-35(63)24-37(62)46(66)52-26-33-16-18-34(19-17-33)44-31(2)54-29-69-44/h11-13,16-19,25,27,29,35,37,45,63H,7-10,14-15,20-24,26,28H2,1-6H3,(H,52,66)(H,58,64)(H,59,67)(H,53,55,56,57)/t35-,37+,45-/m1/s1","YGQREOJIRFCRKQ-ZIBKGDFVSA-N"
"467","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","17.9","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","37.6","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","998.677","997.38579832","6.94","69","7","14","5","17","214.98","C49H60ClN11O6S2","InChI=1S/C49H60ClN11O6S2/c1-29-11-10-12-35(50)42(29)58-46(66)37-26-52-48(69-37)56-38-24-39(55-31(3)54-38)59-19-21-60(22-20-59)41(64)14-9-7-8-13-40(63)57-44(49(4,5)6)47(67)61-27-34(62)23-36(61)45(65)51-25-32-15-17-33(18-16-32)43-30(2)53-28-68-43/h10-12,15-18,24,26,28,34,36,44,62H,7-9,13-14,19-23,25,27H2,1-6H3,(H,51,65)(H,57,63)(H,58,66)(H,52,54,55,56)/t34-,36+,44-/m1/s1","VOJOCZVLPUNKIS-GUXJVCHGSA-N"
"468","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","34.7","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","89","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","984.65","983.370148256","6.4","68","7","14","5","16","214.98","C48H58ClN11O6S2","InChI=1S/C48H58ClN11O6S2/c1-28-10-9-11-34(49)41(28)57-45(65)36-25-51-47(68-36)55-37-23-38(54-30(3)53-37)58-18-20-59(21-19-58)40(63)13-8-7-12-39(62)56-43(48(4,5)6)46(66)60-26-33(61)22-35(60)44(64)50-24-31-14-16-32(17-15-31)42-29(2)52-27-67-42/h9-11,14-17,23,25,27,33,35,43,61H,7-8,12-13,18-22,24,26H2,1-6H3,(H,50,64)(H,56,62)(H,57,65)(H,51,53,54,55)/t33-,35+,43-/m1/s1","VWQBGMDEQXASJE-MXYPERTFSA-N"
"469","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","40.2","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","87","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","970.623","969.354498192","6.04","67","7","14","5","15","214.98","C47H56ClN11O6S2","InChI=1S/C47H56ClN11O6S2/c1-27-9-7-10-33(48)40(27)56-44(64)35-24-50-46(67-35)54-36-22-37(53-29(3)52-36)57-17-19-58(20-18-57)39(62)12-8-11-38(61)55-42(47(4,5)6)45(65)59-25-32(60)21-34(59)43(63)49-23-30-13-15-31(16-14-30)41-28(2)51-26-66-41/h7,9-10,13-16,22,24,26,32,34,42,60H,8,11-12,17-21,23,25H2,1-6H3,(H,49,63)(H,55,61)(H,56,64)(H,50,52,53,54)/t32-,34+,42-/m1/s1","GBRSKPWVXGJTRM-SYVXFDQESA-N"
"470","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","611.4","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","78","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","956.596","955.338848128","5.68","66","7","14","5","14","214.98","C46H54ClN11O6S2","InChI=1S/C46H54ClN11O6S2/c1-26-8-7-9-32(47)39(26)55-43(63)34-23-49-45(66-34)53-35-21-36(52-28(3)51-35)56-16-18-57(19-17-56)38(61)15-14-37(60)54-41(46(4,5)6)44(64)58-24-31(59)20-33(58)42(62)48-22-29-10-12-30(13-11-29)40-27(2)50-25-65-40/h7-13,21,23,25,31,33,41,59H,14-20,22,24H2,1-6H3,(H,48,62)(H,54,60)(H,55,63)(H,49,51,52,53)/t31-,33+,41-/m1/s1","BAMNKVFIYWQPKH-VYLGKBOWSA-N"
"471","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)N=N3)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1079.755","1078.41849542","6.09","75","8","17","5","19","245.69","C52H63ClN14O6S2","InChI=1S/C52H63ClN14O6S2/c1-31-10-7-12-38(53)45(31)61-49(72)40-27-55-51(75-40)59-41-25-42(58-33(3)57-41)64-20-22-65(23-21-64)44(70)14-8-11-36-28-66(63-62-36)19-9-13-43(69)60-47(52(4,5)6)50(73)67-29-37(68)24-39(67)48(71)54-26-34-15-17-35(18-16-34)46-32(2)56-30-74-46/h7,10,12,15-18,25,27-28,30,37,39,47,68H,8-9,11,13-14,19-24,26,29H2,1-6H3,(H,54,71)(H,60,69)(H,61,72)(H,55,57,58,59)/t37-,39+,47-/m1/s1","PHFXGJZBSPKGSV-PHQHQIPESA-N"
"472","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CNC(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","68.2","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1027.675","1026.37596191","5.39","71","7","15","6","17","244.08","C49H59ClN12O7S2","InChI=1S/C49H59ClN12O7S2/c1-28-9-7-10-34(50)42(28)59-46(68)36-24-53-48(71-36)57-37-22-38(56-30(3)55-37)60-17-19-61(20-18-60)41(66)25-51-39(64)11-8-12-40(65)58-44(49(4,5)6)47(69)62-26-33(63)21-35(62)45(67)52-23-31-13-15-32(16-14-31)43-29(2)54-27-70-43/h7,9-10,13-16,22,24,27,33,35,44,63H,8,11-12,17-21,23,25-26H2,1-6H3,(H,51,64)(H,52,67)(H,58,65)(H,59,68)(H,53,55,56,57)/t33-,35+,44-/m1/s1","ZCNFPTGTYRKPDH-TXDFNTDUSA-N"
"473","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","72","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1139.891","1138.50116242","8.53","79","7","15","6","25","244.08","C57H75ClN12O7S2","InChI=1S/C57H75ClN12O7S2/c1-36-16-15-17-42(58)50(36)67-54(76)44-33-61-56(79-44)65-45-31-46(64-38(3)63-45)68-26-28-69(29-27-68)49(74)20-13-14-25-59-47(72)18-11-9-7-8-10-12-19-48(73)66-52(57(4,5)6)55(77)70-34-41(71)30-43(70)53(75)60-32-39-21-23-40(24-22-39)51-37(2)62-35-78-51/h15-17,21-24,31,33,35,41,43,52,71H,7-14,18-20,25-30,32,34H2,1-6H3,(H,59,72)(H,60,75)(H,66,73)(H,67,76)(H,61,63,64,65)/t41-,43+,52-/m1/s1","NODYCJOTMWVMEX-OGAKFCHGSA-N"
"474","","BCR-ABL","VHL","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=N1","","","","0","% BCR-ABL degradation in K562 cells after 16 h treatment at 10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.9","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01264","1125.908","1124.52189786","9.49","78","7","15","6","26","227.01","C57H77ClN12O6S2","InChI=1S/C57H77ClN12O6S2/c1-37-17-16-18-43(58)50(37)67-54(75)45-34-61-56(78-45)65-46-32-47(64-39(3)63-46)69-29-27-68(28-30-69)26-15-11-14-25-59-48(72)19-12-9-7-8-10-13-20-49(73)66-52(57(4,5)6)55(76)70-35-42(71)31-44(70)53(74)60-33-40-21-23-41(24-22-40)51-38(2)62-36-77-51/h16-18,21-24,32,34,36,42,44,52,71H,7-15,19-20,25-31,33,35H2,1-6H3,(H,59,72)(H,60,74)(H,66,73)(H,67,75)(H,61,63,64,65)/t42-,44+,52-/m1/s1","CMQKWNXYMLROCG-MQLXHLMQSA-N"
"475","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","2630","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","950","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1130.112","1129.39106137","2.17","81","9","10","8","17","310.81","C57H58F2N9O12P","InChI=1S/C57H58F2N9O12P/c58-57(59,81(78,79)80)37-19-21-41-36(29-37)30-43(61-41)52(73)63-44-32-66(49(71)18-9-3-4-11-33-16-10-17-39-40(33)31-67(55(39)76)45-24-26-48(70)64-53(45)74)28-27-38-20-23-46(68(38)56(44)77)54(75)62-42(22-25-47(60)69)51(72)65-50(34-12-5-1-6-13-34)35-14-7-2-8-15-35/h1-2,5-8,10,12-17,19,21,29-30,38,42,44-46,50,61H,3,9,18,20,22-28,31-32H2,(H2,60,69)(H,62,75)(H,63,73)(H,65,72)(H,64,70,74)(H2,78,79,80)/t38-,42+,44+,45?,46+/m1/s1","JUVLSKPPPVWKIB-RZJNVLOKSA-N"
"476","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","260","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","78","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1144.139","1143.40671143","2.71","82","9","10","8","18","310.81","C58H60F2N9O12P","InChI=1S/C58H60F2N9O12P/c59-58(60,82(79,80)81)38-20-22-42-37(30-38)31-44(62-42)53(74)64-45-33-67(50(72)19-10-2-1-5-12-34-17-11-18-40-41(34)32-68(56(40)77)46-25-27-49(71)65-54(46)75)29-28-39-21-24-47(69(39)57(45)78)55(76)63-43(23-26-48(61)70)52(73)66-51(35-13-6-3-7-14-35)36-15-8-4-9-16-36/h3-4,6-9,11,13-18,20,22,30-31,39,43,45-47,51,62H,1-2,10,19,21,23-29,32-33H2,(H2,61,70)(H,63,76)(H,64,74)(H,66,73)(H,65,71,75)(H2,79,80,81)/t39-,43+,45+,46?,47+/m1/s1","BDYQRBRHLWXHSV-ALXJROBFSA-N"
"477","P40763","STAT3","CRBN","","SD-36","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","60/28","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13/610","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1158.166","1157.42236149","3.25","83","9","10","8","19","310.81","C59H62F2N9O12P","InChI=1S/C59H62F2N9O12P/c60-59(61,83(80,81)82)39-21-23-43-38(31-39)32-45(63-43)54(75)65-46-34-68(51(73)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-69(57(41)78)47-26-28-50(72)66-55(47)76)30-29-40-22-25-48(70(40)58(46)79)56(77)64-44(24-27-49(62)71)53(74)67-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37/h4-5,7-10,12,14-19,21,23,31-32,40,44,46-48,52,63H,1-3,11,20,22,24-30,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t40-,44+,46+,47?,48+/m1/s1","JKCSCHXVWPSGBG-OPKPGBGESA-N"
"478","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","90","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1172.193","1171.43801156","3.8","84","9","10","8","20","310.81","C60H64F2N9O12P","InChI=1S/C60H64F2N9O12P/c61-60(62,84(81,82)83)40-22-24-44-39(32-40)33-46(64-44)55(76)66-47-35-69(52(74)21-12-4-2-1-3-7-14-36-19-13-20-42-43(36)34-70(58(42)79)48-27-29-51(73)67-56(48)77)31-30-41-23-26-49(71(41)59(47)80)57(78)65-45(25-28-50(63)72)54(75)68-53(37-15-8-5-9-16-37)38-17-10-6-11-18-38/h5-6,8-11,13,15-20,22,24,32-33,41,45,47-49,53,64H,1-4,12,21,23,25-31,34-35H2,(H2,63,72)(H,65,78)(H,66,76)(H,68,75)(H,67,73,77)(H2,81,82,83)/t41-,45+,47+,48?,49+/m1/s1","PSOLZBBCSLPKNE-MCIGMSQYSA-N"
"479","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","150","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1200.247","1199.46931169","4.88","86","9","10","8","22","310.81","C62H68F2N9O12P","InChI=1S/C62H68F2N9O12P/c63-62(64,86(83,84)85)42-24-26-46-41(34-42)35-48(66-46)57(78)68-49-37-71(54(76)23-14-6-4-2-1-3-5-9-16-38-21-15-22-44-45(38)36-72(60(44)81)50-29-31-53(75)69-58(50)79)33-32-43-25-28-51(73(43)61(49)82)59(80)67-47(27-30-52(65)74)56(77)70-55(39-17-10-7-11-18-39)40-19-12-8-13-20-40/h7-8,10-13,15,17-22,24,26,34-35,43,47,49-51,55,66H,1-6,14,23,25,27-33,36-37H2,(H2,65,74)(H,67,80)(H,68,78)(H,70,77)(H,69,75,79)(H2,83,84,85)/t43-,47+,49+,50?,51+/m1/s1","MSFCNZZBAJYPCP-AACVIFBVSA-N"
"480","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(CCCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","650/919","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","147/>100000","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1144.183","1143.44309694","1.94","82","9","10","8","20","293.74","C59H64F2N9O11P","InChI=1S/C59H64F2N9O11P/c60-59(61,82(79,80)81)40-21-23-44-39(32-40)33-46(63-44)54(74)65-47-35-68(30-12-4-2-1-3-7-14-36-19-13-20-42-43(36)34-69(57(42)77)48-26-28-51(72)66-55(48)75)31-29-41-22-25-49(70(41)58(47)78)56(76)64-45(24-27-50(62)71)53(73)67-52(37-15-8-5-9-16-37)38-17-10-6-11-18-38/h5-6,8-11,13,15-21,23,32-33,41,45,47-49,52,63H,1-4,12,22,24-31,34-35H2,(H2,62,71)(H,64,76)(H,65,74)(H,67,73)(H,66,72,75)(H2,79,80,81)/t41-,45+,47+,48?,49+/m1/s1","STTINLOVDTUWIQ-MCIGMSQYSA-N"
"481","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)OCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","240/49","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","128/2370","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1160.138","1159.40162605","3.0","83","9","11","8","18","320.04","C58H60F2N9O13P","InChI=1S/C58H60F2N9O13P/c59-58(60,83(79,80)81)38-19-21-42-37(30-38)31-44(62-42)52(73)64-45-33-67(57(78)82-29-10-2-1-5-12-34-17-11-18-40-41(34)32-68(55(40)76)46-24-26-49(71)65-53(46)74)28-27-39-20-23-47(69(39)56(45)77)54(75)63-43(22-25-48(61)70)51(72)66-50(35-13-6-3-7-14-35)36-15-8-4-9-16-36/h3-4,6-9,11,13-19,21,30-31,39,43,45-47,50,62H,1-2,10,20,22-29,32-33H2,(H2,61,70)(H,63,75)(H,64,73)(H,66,72)(H,65,71,74)(H2,79,80,81)/t39-,43+,45+,46?,47+/m1/s1","AYDCOOQDCPYUIU-ALXJROBFSA-N"
"482","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)NCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","50/11","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","91/430","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1159.154","1158.41761046","2.42","83","9","10","9","18","322.84","C58H61F2N10O12P","InChI=1S/C58H61F2N10O12P/c59-58(60,83(80,81)82)38-19-21-42-37(30-38)31-44(63-42)52(74)65-45-33-68(57(79)62-28-10-2-1-5-12-34-17-11-18-40-41(34)32-69(55(40)77)46-24-26-49(72)66-53(46)75)29-27-39-20-23-47(70(39)56(45)78)54(76)64-43(22-25-48(61)71)51(73)67-50(35-13-6-3-7-14-35)36-15-8-4-9-16-36/h3-4,6-9,11,13-19,21,30-31,39,43,45-47,50,63H,1-2,10,20,22-29,32-33H2,(H2,61,71)(H,62,79)(H,64,76)(H,65,74)(H,67,73)(H,66,72,75)(H2,80,81,82)/t39-,43+,45+,46?,47+/m1/s1","ZNTHSJGRFSTPKW-ALXJROBFSA-N"
"483","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)C3=CN(CCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=C3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","180","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","241","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1196.175","1195.41285943","2.14","86","10","12","8","18","328.63","C60H60F2N11O12P","InChI=1S/C60H60F2N11O12P/c61-60(62,86(83,84)85)40-18-20-44-38(29-40)30-46(65-44)54(77)67-47-34-70(57(80)39-31-64-71(32-39)27-9-3-8-11-35-16-10-17-42-43(35)33-72(58(42)81)48-23-25-51(75)68-55(48)78)28-26-41-19-22-49(73(41)59(47)82)56(79)66-45(21-24-50(63)74)53(76)69-52(36-12-4-1-5-13-36)37-14-6-2-7-15-37/h1-2,4-7,10,12-18,20,29-32,41,45,47-49,52,65H,3,9,19,21-28,33-34H2,(H2,63,74)(H,66,79)(H,67,77)(H,69,76)(H,68,75,78)(H2,83,84,85)/t41-,45+,47+,48?,49+/m1/s1","GRFIIYLYEIAGDZ-MCIGMSQYSA-N"
"484","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCN3C=C(C#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=N3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","250","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","232","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1196.175","1195.41285943","1.78","86","10","12","8","18","328.63","C60H60F2N11O12P","InChI=1S/C60H60F2N11O12P/c61-60(62,86(83,84)85)40-18-20-44-39(29-40)30-46(65-44)55(78)67-47-34-70(52(76)15-8-27-71-32-35(31-64-71)16-17-36-13-7-14-42-43(36)33-72(58(42)81)48-23-25-51(75)68-56(48)79)28-26-41-19-22-49(73(41)59(47)82)57(80)66-45(21-24-50(63)74)54(77)69-53(37-9-3-1-4-10-37)38-11-5-2-6-12-38/h1-7,9-14,18,20,29-32,41,45,47-49,53,65H,8,15,19,21-28,33-34H2,(H2,63,74)(H,66,80)(H,67,78)(H,69,77)(H,68,75,79)(H2,83,84,85)/t41-,45+,47+,48?,49+/m1/s1","ITISWPJBZKPZQW-MCIGMSQYSA-N"
"485","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)N3CCC(CCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","180","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","99","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1199.219","1198.44891059","3.18","86","10","10","8","16","314.05","C61H65F2N10O12P","InChI=1S/C61H65F2N10O12P/c62-61(63,86(83,84)85)41-18-20-45-40(32-41)33-47(65-45)55(77)67-48-35-71(60(82)70-29-26-36(27-30-70)10-7-8-11-37-16-9-17-43-44(37)34-72(58(43)80)49-23-25-52(75)68-56(49)78)31-28-42-19-22-50(73(42)59(48)81)57(79)66-46(21-24-51(64)74)54(76)69-53(38-12-3-1-4-13-38)39-14-5-2-6-15-39/h1-6,9,12-18,20,32-33,36,42,46,48-50,53,65H,7,10,19,21-31,34-35H2,(H2,64,74)(H,66,79)(H,67,77)(H,69,76)(H,68,75,78)(H2,83,84,85)/t42-,46+,48+,49?,50+/m1/s1","DNUHNFLKEFZIJN-RNJJLJFWSA-N"
"486","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCN3CCC(C#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","2470","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","360","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1199.219","1198.44891059","-0.15","86","10","11","8","17","314.05","C61H65F2N10O12P","InChI=1S/C61H65F2N10O12P/c62-61(63,86(83,84)85)41-16-18-45-40(32-41)33-47(65-45)56(78)67-48-35-71(53(76)27-30-70-28-24-36(25-29-70)14-15-37-12-7-13-43-44(37)34-72(59(43)81)49-21-23-52(75)68-57(49)79)31-26-42-17-20-50(73(42)60(48)82)58(80)66-46(19-22-51(64)74)55(77)69-54(38-8-3-1-4-9-38)39-10-5-2-6-11-39/h1-13,16,18,32-33,36,42,46,48-50,54,65H,17,19-31,34-35H2,(H2,64,74)(H,66,80)(H,67,78)(H,69,77)(H,68,75,79)(H2,83,84,85)/t42-,46+,48+,49?,50+/m1/s1","FDBBKBSMSHLUPL-RNJJLJFWSA-N"
"487","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CC(=O)N3CCC(C#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","380","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","67","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1213.202","1212.42817515","1.79","87","10","11","8","16","331.12","C61H63F2N10O13P","InChI=1S/C61H63F2N10O13P/c62-61(63,87(84,85)86)40-16-18-44-39(30-40)31-46(65-44)56(79)67-47-34-71(53(77)32-52(76)70-27-24-35(25-28-70)14-15-36-12-7-13-42-43(36)33-72(59(42)82)48-21-23-51(75)68-57(48)80)29-26-41-17-20-49(73(41)60(47)83)58(81)66-45(19-22-50(64)74)55(78)69-54(37-8-3-1-4-9-37)38-10-5-2-6-11-38/h1-13,16,18,30-31,35,41,45,47-49,54,65H,17,19-29,32-34H2,(H2,64,74)(H,66,81)(H,67,79)(H,69,78)(H,68,75,80)(H2,84,85,86)/t41-,45+,47+,48?,49+/m1/s1","DNVSITWTEKNBFF-MCIGMSQYSA-N"
"488","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","160","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","63","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1162.198","1161.45366162","3.94","83","9","10","8","22","310.81","C59H66F2N9O12P","InChI=1S/C59H66F2N9O12P/c60-59(61,83(80,81)82)39-21-23-43-38(31-39)32-45(63-43)54(75)65-46-34-68(51(73)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-69(57(41)78)47-26-28-50(72)66-55(47)76)30-29-40-22-25-48(70(40)58(46)79)56(77)64-44(24-27-49(62)71)53(74)67-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37/h4-5,7-10,12,14-19,21,23,31-32,40,44,46-48,52,63H,1-3,6,11,13,20,22,24-30,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t40-,44+,46+,47?,48+/m1/s1","FXYCZGNLHMEDSW-OPKPGBGESA-N"
"489","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","90","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","59","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1163.186","1162.44891059","2.76","83","9","11","9","22","322.84","C58H65F2N10O12P","InChI=1S/C58H65F2N10O12P/c59-58(60,83(80,81)82)37-19-21-41-36(30-37)31-44(63-41)53(75)65-45-33-68(50(73)18-9-1-2-10-28-62-42-17-11-16-39-40(42)32-69(56(39)78)46-24-26-49(72)66-54(46)76)29-27-38-20-23-47(70(38)57(45)79)55(77)64-43(22-25-48(61)71)52(74)67-51(34-12-5-3-6-13-34)35-14-7-4-8-15-35/h3-8,11-17,19,21,30-31,38,43,45-47,51,62-63H,1-2,9-10,18,20,22-29,32-33H2,(H2,61,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t38-,43+,45+,46?,47+/m1/s1","XPIZROMNDAHUBB-ZSAPAZMUSA-N"
"490","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","3540/>10000","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","582/>10000","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1172.149","1171.40162605","3.2","84","9","11","8","19","327.88","C59H60F2N9O13P","InChI=1S/C59H60F2N9O13P/c60-59(61,84(81,82)83)38-21-23-41-37(31-38)32-43(63-41)53(75)65-44-33-68(49(73)20-11-3-1-2-6-13-34-18-12-19-40-50(34)58(80)70(56(40)78)46-26-28-48(72)66-55(46)77)30-29-39-22-25-45(69(39)57(44)79)54(76)64-42(24-27-47(62)71)52(74)67-51(35-14-7-4-8-15-35)36-16-9-5-10-17-36/h4-5,7-10,12,14-19,21,23,31-32,39,42,44-46,51,63H,1-3,11,20,22,24-30,33H2,(H2,62,71)(H,64,76)(H,65,75)(H,67,74)(H,66,72,77)(H2,81,82,83)/t39-,42+,44+,45+,46?/m1/s1","ZMCYXBJXBBCEIP-DYGUMZBISA-N"
"491","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","410","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","104","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1158.166","1157.42236149","3.25","83","9","10","8","19","310.81","C59H62F2N9O12P","InChI=1S/C59H62F2N9O12P/c60-59(61,83(80,81)82)40-19-22-43-38(31-40)32-45(63-43)54(75)65-46-34-68(51(73)17-11-3-1-2-6-12-35-18-21-42-39(30-35)33-69(57(42)78)47-25-27-50(72)66-55(47)76)29-28-41-20-24-48(70(41)58(46)79)56(77)64-44(23-26-49(62)71)53(74)67-52(36-13-7-4-8-14-36)37-15-9-5-10-16-37/h4-5,7-10,13-16,18-19,21-22,30-32,41,44,46-48,52,63H,1-3,11,17,20,23-29,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t41-,44+,46+,47?,48+/m1/s1","FXZPXYVHFYRABL-VTOHLSPHSA-N"
"492","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=C4CN(C5CCC(=O)NC5=O)C(=O)C4=C3)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","360","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","711","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1158.166","1157.42236149","3.25","83","9","10","8","19","310.81","C59H62F2N9O12P","InChI=1S/C59H62F2N9O12P/c60-59(61,83(80,81)82)40-20-22-43-39(31-40)32-45(63-43)54(75)65-46-34-68(51(73)17-11-3-1-2-6-12-35-18-19-38-33-69(57(78)42(38)30-35)47-25-27-50(72)66-55(47)76)29-28-41-21-24-48(70(41)58(46)79)56(77)64-44(23-26-49(62)71)53(74)67-52(36-13-7-4-8-14-36)37-15-9-5-10-16-37/h4-5,7-10,13-16,18-20,22,30-32,41,44,46-48,52,63H,1-3,11,17,21,23-29,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t41-,44+,46+,47?,48+/m1/s1","PUAPFJPRVXBTRM-VTOHLSPHSA-N"
"493","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NCC1=CC=CC=C1","220/55","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","210/3240","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1082.068","1081.39106137","1.56","77","8","10","8","18","310.81","C53H58F2N9O12P","InChI=1S/C53H58F2N9O12P/c54-53(55,77(74,75)76)34-16-18-38-33(26-34)27-40(58-38)48(69)60-41-30-62(46(67)15-8-3-1-2-7-12-32-13-9-14-36-37(32)29-63(51(36)72)42-21-23-45(66)61-49(42)70)25-24-35-17-20-43(64(35)52(41)73)50(71)59-39(19-22-44(56)65)47(68)57-28-31-10-5-4-6-11-31/h4-6,9-11,13-14,16,18,26-27,35,39,41-43,58H,1-3,8,15,17,19-25,28-30H2,(H2,56,65)(H,57,68)(H,59,71)(H,60,69)(H,61,66,70)(H2,74,75,76)/t35-,39+,41+,42?,43+/m1/s1","JMUHWFNJLJLSLE-UCJSLEDASA-N"
"494","P40763","STAT3","CRBN","","","CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(F)(F)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12","640/890","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","226/>10000","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1005.97","1005.35976124","0.07","71","7","10","8","16","310.81","C47H54F2N9O12P","InChI=1S/C47H54F2N9O12P/c1-51-41(62)33(15-18-38(50)59)53-44(65)37-16-13-29-20-21-56(25-35(46(67)58(29)37)54-42(63)34-23-27-22-28(12-14-32(27)52-34)47(48,49)71(68,69)70)40(61)11-6-4-2-3-5-8-26-9-7-10-30-31(26)24-57(45(30)66)36-17-19-39(60)55-43(36)64/h7,9-10,12,14,22-23,29,33,35-37,52H,2-4,6,11,13,15-21,24-25H2,1H3,(H2,50,59)(H,51,62)(H,53,65)(H,54,63)(H,55,60,64)(H2,68,69,70)/t29-,33+,35+,36?,37+/m1/s1","YGMZLSZZQXJJGQ-BSGAXWGTSA-N"
"495","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(OP(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1",">10000","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1124.158","1123.42046967","2.88","81","9","11","8","19","320.04","C58H62N9O13P","InChI=1S/C58H62N9O13P/c59-49(68)27-24-44(53(71)64-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37)61-56(74)48-25-21-39-29-30-65(34-46(58(76)67(39)48)62-54(72)45-32-38-31-40(80-81(77,78)79)22-23-43(38)60-45)51(70)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-66(57(41)75)47-26-28-50(69)63-55(47)73/h4-5,7-10,12,14-19,22-23,31-32,39,44,46-48,52,60H,1-3,11,20-21,24-30,33-34H2,(H2,59,68)(H,61,74)(H,62,72)(H,64,71)(H,63,69,73)(H2,77,78,79)/t39-,44+,46+,47?,48+/m1/s1","GHKKHWPDPXWQMX-MWHNVIERSA-N"
"496","P40763","STAT3","CRBN","","","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(CP(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1",">10000","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit growth of Molm-16 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1122.186","1121.44120512","2.51","81","9","10","8","19","310.81","C59H64N9O12P","InChI=1S/C59H64N9O12P/c60-50(69)27-24-45(54(72)65-53(38-14-7-4-8-15-38)39-16-9-5-10-17-39)62-57(75)49-25-22-41-29-30-66(34-47(59(77)68(41)49)63-55(73)46-32-40-31-36(35-81(78,79)80)21-23-44(40)61-46)52(71)20-11-3-1-2-6-13-37-18-12-19-42-43(37)33-67(58(42)76)48-26-28-51(70)64-56(48)74/h4-5,7-10,12,14-19,21,23,31-32,41,45,47-49,53,61H,1-3,11,20,22,24-30,33-35H2,(H2,60,69)(H,62,75)(H,63,73)(H,65,72)(H,64,70,74)(H2,78,79,80)/t41-,45+,47+,48?,49+/m1/s1","JEIWTFIDHFVTPB-MCIGMSQYSA-N"
"497","P40763","STAT3","CRBN","","","C/C(=C\C(=O)N[C@H]1CN(C(=O)CCCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C3=CC=CC=C3)C3=CC=CC=C3)N2C1=O)C1=CC=C(C(F)(F)P(=O)(O)O)C=C1","4450/>10000","","Degradation of total STAT3 and p-STAT3Y705 proteins in Molm-16/SU-DHL-1 cells after 4/16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1250/>10000","Inhibit growth of Molm-16/SU-DHL-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01530","1159.194","1158.44276259","3.84","83","8","10","7","20","295.02","C60H65F2N8O12P","InChI=1S/C60H65F2N8O12P/c1-37(38-22-24-42(25-23-38)60(61,62)83(80,81)82)34-52(73)64-47-36-68(53(74)21-12-4-2-3-7-14-39-19-13-20-44-45(39)35-69(58(44)78)48-29-31-51(72)66-56(48)76)33-32-43-26-28-49(70(43)59(47)79)57(77)65-46(27-30-50(63)71)55(75)67-54(40-15-8-5-9-16-40)41-17-10-6-11-18-41/h5-6,8-11,13,15-20,22-25,34,43,46-49,54H,2-4,12,21,26-33,35-36H2,1H3,(H2,63,71)(H,64,73)(H,65,77)(H,67,75)(H,66,72,76)(H2,80,81,82)/b37-34+/t43-,46+,47+,48?,49+/m1/s1","BEYVGGZLHQFWMW-DOJNSZAGSA-N"
"498","P10415","BCL2","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","15210","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","853.752","852.157695244","4.56","57","7","10","4","15","191.16","C41H37BrN6O8S","InChI=1S/C41H37BrN6O8S/c42-23-11-13-24(14-12-23)57-31-17-15-28-35-25(31)5-3-6-26(35)38(53)47(39(28)54)22-21-45-33(50)10-2-1-9-32(49)44-20-19-43-29-8-4-7-27-36(29)41(56)48(40(27)55)30-16-18-34(51)46-37(30)52/h3-8,11-15,17,30,43H,1-2,9-10,16,18-22H2,(H,44,49)(H,45,50)(H,46,51,52)","GUYBLDKKEQJQDB-UHFFFAOYSA-N"
"498","Q07820","MCL1","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","7890","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","853.752","852.157695244","4.56","57","7","10","4","15","191.16","C41H37BrN6O8S","InChI=1S/C41H37BrN6O8S/c42-23-11-13-24(14-12-23)57-31-17-15-28-35-25(31)5-3-6-26(35)38(53)47(39(28)54)22-21-45-33(50)10-2-1-9-32(49)44-20-19-43-29-8-4-7-27-36(29)41(56)48(40(27)55)30-16-18-34(51)46-37(30)52/h3-8,11-15,17,30,43H,1-2,9-10,16,18-22H2,(H,44,49)(H,45,50)(H,46,51,52)","GUYBLDKKEQJQDB-UHFFFAOYSA-N"
"499","P10415","BCL2","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","10020","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","881.806","880.188995372","5.27","59","7","10","4","17","191.16","C43H41BrN6O8S","InChI=1S/C43H41BrN6O8S/c44-25-13-15-26(16-14-25)59-33-19-17-30-37-27(33)7-5-8-28(37)40(55)49(41(30)56)24-23-47-35(52)12-2-1-11-34(51)46-22-4-3-21-45-31-10-6-9-29-38(31)43(58)50(42(29)57)32-18-20-36(53)48-39(32)54/h5-10,13-17,19,32,45H,1-4,11-12,18,20-24H2,(H,46,51)(H,47,52)(H,48,53,54)","UOIGFVBHULUDBF-UHFFFAOYSA-N"
"499","Q07820","MCL1","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","1510","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","881.806","880.188995372","5.27","59","7","10","4","17","191.16","C43H41BrN6O8S","InChI=1S/C43H41BrN6O8S/c44-25-13-15-26(16-14-25)59-33-19-17-30-37-27(33)7-5-8-28(37)40(55)49(41(30)56)24-23-47-35(52)12-2-1-11-34(51)46-22-4-3-21-45-31-10-6-9-29-38(31)43(58)50(42(29)57)32-18-20-36(53)48-39(32)54/h5-10,13-17,19,32,45H,1-4,11-12,18,20-24H2,(H,46,51)(H,47,52)(H,48,53,54)","UOIGFVBHULUDBF-UHFFFAOYSA-N"
"500","P10415","BCL2","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","540","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","909.86","908.2202955","5.98","61","7","10","4","19","191.16","C45H45BrN6O8S","InChI=1S/C45H45BrN6O8S/c46-27-15-17-28(18-16-27)61-35-21-19-32-39-29(35)9-7-10-30(39)42(57)51(43(32)58)26-25-49-37(54)14-4-3-13-36(53)48-24-6-2-1-5-23-47-33-12-8-11-31-40(33)45(60)52(44(31)59)34-20-22-38(55)50-41(34)56/h7-12,15-19,21,34,47H,1-6,13-14,20,22-26H2,(H,48,53)(H,49,54)(H,50,55,56)","BORXNUWYWZOREQ-UHFFFAOYSA-N"
"500","Q07820","MCL1","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","700","","Degradation of MCL1 in HeLa cells after 12 h treatment","","","780","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","909.86","908.2202955","5.98","61","7","10","4","19","191.16","C45H45BrN6O8S","InChI=1S/C45H45BrN6O8S/c46-27-15-17-28(18-16-27)61-35-21-19-32-39-29(35)9-7-10-30(39)42(57)51(43(32)58)26-25-49-37(54)14-4-3-13-36(53)48-24-6-2-1-5-23-47-33-12-8-11-31-40(33)45(60)52(44(31)59)34-20-22-38(55)50-41(34)56/h7-12,15-19,21,34,47H,1-6,13-14,20,22-26H2,(H,48,53)(H,49,54)(H,50,55,56)","BORXNUWYWZOREQ-UHFFFAOYSA-N"
"501","P10415","BCL2","CRBN","","","O=C(CCCCCNC(=O)CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","13470","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","1023.02","1021.30435947","6.3","69","7","11","5","25","220.26","C51H56BrN7O9S","InChI=1S/C51H56BrN7O9S/c52-32-19-21-33(22-20-32)69-40-25-23-37-45-34(40)12-10-13-35(45)48(65)58(49(37)66)31-30-56-43(62)18-6-5-17-42(61)55-29-9-3-4-16-41(60)54-28-8-2-1-7-27-53-38-15-11-14-36-46(38)51(68)59(50(36)67)39-24-26-44(63)57-47(39)64/h10-15,19-23,25,39,53H,1-9,16-18,24,26-31H2,(H,54,60)(H,55,61)(H,56,62)(H,57,63,64)","YQNUVPHVABDQCX-UHFFFAOYSA-N"
"501","Q07820","MCL1","CRBN","","","O=C(CCCCCNC(=O)CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","15120","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","1023.02","1021.30435947","6.3","69","7","11","5","25","220.26","C51H56BrN7O9S","InChI=1S/C51H56BrN7O9S/c52-32-19-21-33(22-20-32)69-40-25-23-37-45-34(40)12-10-13-35(45)48(65)58(49(37)66)31-30-56-43(62)18-6-5-17-42(61)55-29-9-3-4-16-41(60)54-28-8-2-1-7-27-53-38-15-11-14-36-46(38)51(68)59(50(36)67)39-24-26-44(63)57-47(39)64/h10-15,19-23,25,39,53H,1-9,16-18,24,26-31H2,(H,54,60)(H,55,61)(H,56,62)(H,57,63,64)","YQNUVPHVABDQCX-UHFFFAOYSA-N"
"502","Q07820","MCL1","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","11810","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","941.858","940.21012474","4.26","63","7","12","4","21","209.62","C45H45BrN6O10S","InChI=1S/C45H45BrN6O10S/c46-27-11-13-28(14-12-27)63-35-17-15-32-39-29(35)5-3-6-30(39)42(57)51(43(32)58)22-19-48-36(53)9-1-2-10-37(54)49-21-24-62-26-25-61-23-20-47-33-8-4-7-31-40(33)45(60)52(44(31)59)34-16-18-38(55)50-41(34)56/h3-8,11-15,17,34,47H,1-2,9-10,16,18-26H2,(H,48,53)(H,49,54)(H,50,55,56)","IUSLKFLLLNNOGR-UHFFFAOYSA-N"
"502","P10415","BCL2","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","3000","","Degradation of BCL2 in HeLa cells after 12 h treatment","","","4940","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","941.858","940.21012474","4.26","63","7","12","4","21","209.62","C45H45BrN6O10S","InChI=1S/C45H45BrN6O10S/c46-27-11-13-28(14-12-27)63-35-17-15-32-39-29(35)5-3-6-30(39)42(57)51(43(32)58)22-19-48-36(53)9-1-2-10-37(54)49-21-24-62-26-25-61-23-20-47-33-8-4-7-31-40(33)45(60)52(44(31)59)34-16-18-38(55)50-41(34)56/h3-8,11-15,17,34,47H,1-2,9-10,16,18-26H2,(H,48,53)(H,49,54)(H,50,55,56)","IUSLKFLLLNNOGR-UHFFFAOYSA-N"
"503","P10415","BCL2","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","7660","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","937.914","936.251595628","7.07","63","7","10","4","21","191.16","C47H49BrN6O8S","InChI=1S/C47H49BrN6O8S/c48-29-17-19-30(20-18-29)63-37-23-21-34-41-31(37)11-9-12-32(41)44(59)53(45(34)60)28-27-51-39(56)16-6-5-15-38(55)50-26-8-4-2-1-3-7-25-49-35-14-10-13-33-42(35)47(62)54(46(33)61)36-22-24-40(57)52-43(36)58/h9-14,17-21,23,36,49H,1-8,15-16,22,24-28H2,(H,50,55)(H,51,56)(H,52,57,58)","HPWZXUNXZTTXOO-UHFFFAOYSA-N"
"503","Q07820","MCL1","CRBN","","","O=C(CCCCC(=O)NCCN1C(=O)C2=CC=CC3=C(SC4=CC=C(Br)C=C4)C=CC(=C23)C1=O)NCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","5400","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","937.914","936.251595628","7.07","63","7","10","4","21","191.16","C47H49BrN6O8S","InChI=1S/C47H49BrN6O8S/c48-29-17-19-30(20-18-29)63-37-23-21-34-41-31(37)11-9-12-32(41)44(59)53(45(34)60)28-27-51-39(56)16-6-5-15-38(55)50-26-8-4-2-1-3-7-25-49-35-14-10-13-33-42(35)47(62)54(46(33)61)36-22-24-40(57)52-43(36)58/h9-14,17-21,23,36,49H,1-8,15-16,22,24-28H2,(H,50,55)(H,51,56)(H,52,57,58)","HPWZXUNXZTTXOO-UHFFFAOYSA-N"
"504","P10415","BCL2","CRBN","","","N#CC1=C(NCCC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","10480","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","777.657","776.105265748","5.81","52","7","10","4","11","177.57","C38H29BrN6O6S","InChI=1S/C38H29BrN6O6S/c39-20-7-9-21(10-8-20)52-29-13-11-23-32-22(29)3-1-4-24(32)35(48)26(19-40)34(23)43-16-15-30(46)42-18-17-41-27-6-2-5-25-33(27)38(51)45(37(25)50)28-12-14-31(47)44-36(28)49/h1-11,13,28,41,43H,12,14-18H2,(H,42,46)(H,44,47,49)","KGPAYUWULZYDPQ-UHFFFAOYSA-N"
"504","Q07820","MCL1","CRBN","","","N#CC1=C(NCCC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","10640","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","777.657","776.105265748","5.81","52","7","10","4","11","177.57","C38H29BrN6O6S","InChI=1S/C38H29BrN6O6S/c39-20-7-9-21(10-8-20)52-29-13-11-23-32-22(29)3-1-4-24(32)35(48)26(19-40)34(23)43-16-15-30(46)42-18-17-41-27-6-2-5-25-33(27)38(51)45(37(25)50)28-12-14-31(47)44-36(28)49/h1-11,13,28,41,43H,12,14-18H2,(H,42,46)(H,44,47,49)","KGPAYUWULZYDPQ-UHFFFAOYSA-N"
"505","P10415","BCL2","CRBN","","","N#CC1=C(NCCC(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","9710","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","805.711","804.136565876","6.52","54","7","10","4","13","177.57","C40H33BrN6O6S","InChI=1S/C40H33BrN6O6S/c41-22-9-11-23(12-10-22)54-31-15-13-25-34-24(31)5-3-6-26(34)37(50)28(21-42)36(25)45-20-17-32(48)44-19-2-1-18-43-29-8-4-7-27-35(29)40(53)47(39(27)52)30-14-16-33(49)46-38(30)51/h3-13,15,30,43,45H,1-2,14,16-20H2,(H,44,48)(H,46,49,51)","NJPMNDWUBVDRQS-UHFFFAOYSA-N"
"505","Q07820","MCL1","CRBN","","","N#CC1=C(NCCC(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","9950","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","805.711","804.136565876","6.52","54","7","10","4","13","177.57","C40H33BrN6O6S","InChI=1S/C40H33BrN6O6S/c41-22-9-11-23(12-10-22)54-31-15-13-25-34-24(31)5-3-6-26(34)37(50)28(21-42)36(25)45-20-17-32(48)44-19-2-1-18-43-29-8-4-7-27-35(29)40(53)47(39(27)52)30-14-16-33(49)46-38(30)51/h3-13,15,30,43,45H,1-2,14,16-20H2,(H,44,48)(H,46,49,51)","NJPMNDWUBVDRQS-UHFFFAOYSA-N"
"506","P10415","BCL2","CRBN","","","N#CC1=C(NCCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","1940","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","833.765","832.167866004","7.24","56","7","10","4","15","177.57","C42H37BrN6O6S","InChI=1S/C42H37BrN6O6S/c43-24-11-13-25(14-12-24)56-33-17-15-27-36-26(33)7-5-8-28(36)39(52)30(23-44)38(27)47-22-19-34(50)46-21-4-2-1-3-20-45-31-10-6-9-29-37(31)42(55)49(41(29)54)32-16-18-35(51)48-40(32)53/h5-15,17,32,45,47H,1-4,16,18-22H2,(H,46,50)(H,48,51,53)","BFASFHPRUZXSSC-UHFFFAOYSA-N"
"506","Q07820","MCL1","CRBN","","","N#CC1=C(NCCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","7650","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","833.765","832.167866004","7.24","56","7","10","4","15","177.57","C42H37BrN6O6S","InChI=1S/C42H37BrN6O6S/c43-24-11-13-25(14-12-24)56-33-17-15-27-36-26(33)7-5-8-28(36)39(52)30(23-44)38(27)47-22-19-34(50)46-21-4-2-1-3-20-45-31-10-6-9-29-37(31)42(55)49(41(29)54)32-16-18-35(51)48-40(32)53/h5-15,17,32,45,47H,1-4,16,18-22H2,(H,46,50)(H,48,51,53)","BFASFHPRUZXSSC-UHFFFAOYSA-N"
"507","P10415","BCL2","CRBN","","","N#CC1=C(NCCC(=O)NCCCCCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","11650","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","946.925","945.251929976","7.56","64","7","11","5","21","206.67","C48H48BrN7O7S","InChI=1S/C48H48BrN7O7S/c49-29-15-17-30(18-16-29)64-38-21-19-32-42-31(38)10-8-11-33(42)45(60)35(28-50)44(32)54-27-23-40(58)53-26-7-3-4-14-39(57)52-25-6-2-1-5-24-51-36-13-9-12-34-43(36)48(63)56(47(34)62)37-20-22-41(59)55-46(37)61/h8-13,15-19,21,37,51,54H,1-7,14,20,22-27H2,(H,52,57)(H,53,58)(H,55,59,61)","OTPNEQMODCNHMR-UHFFFAOYSA-N"
"507","Q07820","MCL1","CRBN","","","N#CC1=C(NCCC(=O)NCCCCCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","16010.0","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","946.925","945.251929976","7.56","64","7","11","5","21","206.67","C48H48BrN7O7S","InChI=1S/C48H48BrN7O7S/c49-29-15-17-30(18-16-29)64-38-21-19-32-42-31(38)10-8-11-33(42)45(60)35(28-50)44(32)54-27-23-40(58)53-26-7-3-4-14-39(57)52-25-6-2-1-5-24-51-36-13-9-12-34-43(36)48(63)56(47(34)62)37-20-22-41(59)55-46(37)61/h8-13,15-19,21,37,51,54H,1-7,14,20,22-27H2,(H,52,57)(H,53,58)(H,55,59,61)","OTPNEQMODCNHMR-UHFFFAOYSA-N"
"508","P10415","BCL2","CRBN","","","N#CC1=C(NCCC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","2240","Inhibition of BCL2 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","865.763","864.157695244","5.51","58","7","12","4","17","196.03","C42H37BrN6O8S","InChI=1S/C42H37BrN6O8S/c43-24-7-9-25(10-8-24)58-33-13-11-27-36-26(33)3-1-4-28(36)39(52)30(23-44)38(27)47-16-15-34(50)46-18-20-57-22-21-56-19-17-45-31-6-2-5-29-37(31)42(55)49(41(29)54)32-12-14-35(51)48-40(32)53/h1-11,13,32,45,47H,12,14-22H2,(H,46,50)(H,48,51,53)","SXKROLVLGUDXTB-UHFFFAOYSA-N"
"508","Q07820","MCL1","CRBN","","","N#CC1=C(NCCC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C2=C3C(=CC=CC3=C(SC3=CC=C(Br)C=C3)C=C2)C1=O","","","","","","2290","Inhibition of MCL1 by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00919","865.763","864.157695244","5.51","58","7","12","4","17","196.03","C42H37BrN6O8S","InChI=1S/C42H37BrN6O8S/c43-24-7-9-25(10-8-24)58-33-13-11-27-36-26(33)3-1-4-28(36)39(52)30(23-44)38(27)47-16-15-34(50)46-18-20-57-22-21-56-19-17-45-31-6-2-5-29-37(31)42(55)49(41(29)54)32-12-14-35(51)48-40(32)53/h1-11,13,32,45,47H,12,14-22H2,(H,46,50)(H,48,51,53)","SXKROLVLGUDXTB-UHFFFAOYSA-N"
"509","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","999.576","998.37932957","5.47","69","7","14","5","16","211.32","C49H60ClN10O7PS","InChI=1S/C49H60ClN10O7PS/c1-30-43(69-29-53-30)32-14-12-31(13-15-32)26-51-46(64)38-25-34(61)28-60(38)47(65)44(49(2,3)4)56-41(62)18-19-42(63)59-22-20-58(21-23-59)33-16-17-36(39(24-33)67-5)55-48-52-27-35(50)45(57-48)54-37-10-8-9-11-40(37)68(6,7)66/h8-17,24,27,29,34,38,44,61H,18-23,25-26,28H2,1-7H3,(H,51,64)(H,56,62)(H2,52,54,55,57)/t34-,38+,44-/m1/s1","HRCUWBZBTONAAW-VNSGOYEMSA-N"
"510","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1013.603","1012.39497963","5.82","70","7","14","5","17","211.32","C50H62ClN10O7PS","InChI=1S/C50H62ClN10O7PS/c1-31-44(70-30-54-31)33-17-15-32(16-18-33)27-52-47(65)39-26-35(62)29-61(39)48(66)45(50(2,3)4)57-42(63)13-10-14-43(64)60-23-21-59(22-24-60)34-19-20-37(40(25-34)68-5)56-49-53-28-36(51)46(58-49)55-38-11-8-9-12-41(38)69(6,7)67/h8-9,11-12,15-20,25,28,30,35,39,45,62H,10,13-14,21-24,26-27,29H2,1-7H3,(H,52,65)(H,57,63)(H2,53,55,56,58)/t35-,39+,45-/m1/s1","CTIQCRFTOBTJRF-TZEXNLEWSA-N"
"511","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1027.63","1026.4106297","6.18","71","7","14","5","18","211.32","C51H64ClN10O7PS","InChI=1S/C51H64ClN10O7PS/c1-32-45(71-31-55-32)34-18-16-33(17-19-34)28-53-48(66)40-27-36(63)30-62(40)49(67)46(51(2,3)4)58-43(64)14-10-11-15-44(65)61-24-22-60(23-25-61)35-20-21-38(41(26-35)69-5)57-50-54-29-37(52)47(59-50)56-39-12-8-9-13-42(39)70(6,7)68/h8-9,12-13,16-21,26,29,31,36,40,46,63H,10-11,14-15,22-25,27-28,30H2,1-7H3,(H,53,66)(H,58,64)(H2,54,56,57,59)/t36-,40+,46-/m1/s1","YFYICOCFFRXZMM-YKCITUTQSA-N"
"512","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1041.657","1040.42627976","6.72","72","7","14","5","19","211.32","C52H66ClN10O7PS","InChI=1S/C52H66ClN10O7PS/c1-33-46(72-32-56-33)35-19-17-34(18-20-35)29-54-49(67)41-28-37(64)31-63(41)50(68)47(52(2,3)4)59-44(65)15-9-8-10-16-45(66)62-25-23-61(24-26-62)36-21-22-39(42(27-36)70-5)58-51-55-30-38(53)48(60-51)57-40-13-11-12-14-43(40)71(6,7)69/h11-14,17-22,27,30,32,37,41,47,64H,8-10,15-16,23-26,28-29,31H2,1-7H3,(H,54,67)(H,59,65)(H2,55,57,58,60)/t37-,41+,47-/m1/s1","YLLDHMRKOJRPTC-AWWHSMTCSA-N"
"513","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1",">50","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1055.684","1054.44192983","7.26","73","7","14","5","20","211.32","C53H68ClN10O7PS","InChI=1S/C53H68ClN10O7PS/c1-34-47(73-33-57-34)36-20-18-35(19-21-36)30-55-50(68)42-29-38(65)32-64(42)51(69)48(53(2,3)4)60-45(66)16-10-8-9-11-17-46(67)63-26-24-62(25-27-63)37-22-23-40(43(28-37)71-5)59-52-56-31-39(54)49(61-52)58-41-14-12-13-15-44(41)72(6,7)70/h12-15,18-23,28,31,33,38,42,48,65H,8-11,16-17,24-27,29-30,32H2,1-7H3,(H,55,68)(H,60,66)(H2,56,58,59,61)/t38-,42+,48-/m1/s1","KVVNVQLVKFQXHX-AQHSYVBPSA-N"
"514","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","15","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1069.711","1068.45757989","7.8","74","7","14","5","21","211.32","C54H70ClN10O7PS","InChI=1S/C54H70ClN10O7PS/c1-35-48(74-34-58-35)37-21-19-36(20-22-37)31-56-51(69)43-30-39(66)33-65(43)52(70)49(54(2,3)4)61-46(67)17-11-9-8-10-12-18-47(68)64-27-25-63(26-28-64)38-23-24-41(44(29-38)72-5)60-53-57-32-40(55)50(62-53)59-42-15-13-14-16-45(42)73(6,7)71/h13-16,19-24,29,32,34,39,43,49,66H,8-12,17-18,25-28,30-31,33H2,1-7H3,(H,56,69)(H,61,67)(H2,57,59,60,62)/t39-,43+,49-/m1/s1","KHTOZEJDDODCIE-SHTJZPIOSA-N"
"515","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1",">50","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1083.738","1082.47322995","8.35","75","7","14","5","22","211.32","C55H72ClN10O7PS","InChI=1S/C55H72ClN10O7PS/c1-36-49(75-35-59-36)38-22-20-37(21-23-38)32-57-52(70)44-31-40(67)34-66(44)53(71)50(55(2,3)4)62-47(68)18-12-10-8-9-11-13-19-48(69)65-28-26-64(27-29-65)39-24-25-42(45(30-39)73-5)61-54-58-33-41(56)51(63-54)60-43-16-14-15-17-46(43)74(6,7)72/h14-17,20-25,30,33,35,40,44,50,67H,8-13,18-19,26-29,31-32,34H2,1-7H3,(H,57,70)(H,62,68)(H2,58,60,61,63)/t40-,44+,50-/m1/s1","HUMHJRIACKUHDX-PFPUJWRRSA-N"
"516","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1013.603","1012.39497963","6.06","70","7","14","6","17","220.11","C50H62ClN10O7PS","InChI=1S/C50H62ClN10O7PS/c1-30-44(70-29-54-30)32-14-12-31(13-15-32)26-52-47(65)39-25-35(62)28-61(39)48(66)45(50(2,3)4)58-43(64)19-18-42(63)55-33-20-22-60(23-21-33)34-16-17-37(40(24-34)68-5)57-49-53-27-36(51)46(59-49)56-38-10-8-9-11-41(38)69(6,7)67/h8-17,24,27,29,33,35,39,45,62H,18-23,25-26,28H2,1-7H3,(H,52,65)(H,55,63)(H,58,64)(H2,53,56,57,59)/t35-,39+,45-/m1/s1","ZDIRKTGAFJFZSE-TZEXNLEWSA-N"
"517","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1027.63","1026.4106297","6.42","71","7","14","6","18","220.11","C51H64ClN10O7PS","InChI=1S/C51H64ClN10O7PS/c1-31-45(71-30-55-31)33-17-15-32(16-18-33)27-53-48(66)40-26-36(63)29-62(40)49(67)46(51(2,3)4)59-44(65)14-10-13-43(64)56-34-21-23-61(24-22-34)35-19-20-38(41(25-35)69-5)58-50-54-28-37(52)47(60-50)57-39-11-8-9-12-42(39)70(6,7)68/h8-9,11-12,15-20,25,28,30,34,36,40,46,63H,10,13-14,21-24,26-27,29H2,1-7H3,(H,53,66)(H,56,64)(H,59,65)(H2,54,57,58,60)/t36-,40+,46-/m1/s1","YTVIENNAIITSRL-YKCITUTQSA-N"
"518","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1041.657","1040.42627976","6.78","72","7","14","6","19","220.11","C52H66ClN10O7PS","InChI=1S/C52H66ClN10O7PS/c1-32-46(72-31-56-32)34-18-16-33(17-19-34)28-54-49(67)41-27-37(64)30-63(41)50(68)47(52(2,3)4)60-45(66)15-11-10-14-44(65)57-35-22-24-62(25-23-35)36-20-21-39(42(26-36)70-5)59-51-55-29-38(53)48(61-51)58-40-12-8-9-13-43(40)71(6,7)69/h8-9,12-13,16-21,26,29,31,35,37,41,47,64H,10-11,14-15,22-25,27-28,30H2,1-7H3,(H,54,67)(H,57,65)(H,60,66)(H2,55,58,59,61)/t37-,41+,47-/m1/s1","SYWVXBZNWRFYER-AWWHSMTCSA-N"
"519","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1055.684","1054.44192983","7.32","73","7","14","6","20","220.11","C53H68ClN10O7PS","InChI=1S/C53H68ClN10O7PS/c1-33-47(73-32-57-33)35-19-17-34(18-20-35)29-55-50(68)42-28-38(65)31-64(42)51(69)48(53(2,3)4)61-46(67)16-10-8-9-15-45(66)58-36-23-25-63(26-24-36)37-21-22-40(43(27-37)71-5)60-52-56-30-39(54)49(62-52)59-41-13-11-12-14-44(41)72(6,7)70/h11-14,17-22,27,30,32,36,38,42,48,65H,8-10,15-16,23-26,28-29,31H2,1-7H3,(H,55,68)(H,58,66)(H,61,67)(H2,56,59,60,62)/t38-,42+,48-/m1/s1","HTBVHUGFTDJFFU-AQHSYVBPSA-N"
"520","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","9.1","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1069.711","1068.45757989","7.86","74","7","14","6","21","220.11","C54H70ClN10O7PS","InChI=1S/C54H70ClN10O7PS/c1-34-48(74-33-58-34)36-20-18-35(19-21-36)30-56-51(69)43-29-39(66)32-65(43)52(70)49(54(2,3)4)62-47(68)17-11-9-8-10-16-46(67)59-37-24-26-64(27-25-37)38-22-23-41(44(28-38)72-5)61-53-57-31-40(55)50(63-53)60-42-14-12-13-15-45(42)73(6,7)71/h12-15,18-23,28,31,33,37,39,43,49,66H,8-11,16-17,24-27,29-30,32H2,1-7H3,(H,56,69)(H,59,67)(H,62,68)(H2,57,60,61,63)/t39-,43+,49-/m1/s1","QKMSSVGJUBVJIO-SHTJZPIOSA-N"
"521","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","20.9","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1083.738","1082.47322995","8.4","75","7","14","6","22","220.11","C55H72ClN10O7PS","InChI=1S/C55H72ClN10O7PS/c1-35-49(75-34-59-35)37-21-19-36(20-22-37)31-57-52(70)44-30-40(67)33-66(44)53(71)50(55(2,3)4)63-48(69)18-12-10-8-9-11-17-47(68)60-38-25-27-65(28-26-38)39-23-24-42(45(29-39)73-5)62-54-58-32-41(56)51(64-54)61-43-15-13-14-16-46(43)74(6,7)72/h13-16,19-24,29,32,34,38,40,44,50,67H,8-12,17-18,25-28,30-31,33H2,1-7H3,(H,57,70)(H,60,68)(H,63,69)(H2,58,61,62,64)/t40-,44+,50-/m1/s1","LMNCKEZYUHGAAW-PFPUJWRRSA-N"
"522","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","7.2","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1097.765","1096.48888002","8.94","76","7","14","6","23","220.11","C56H74ClN10O7PS","InChI=1S/C56H74ClN10O7PS/c1-36-50(76-35-60-36)38-22-20-37(21-23-38)32-58-53(71)45-31-41(68)34-67(45)54(72)51(56(2,3)4)64-49(70)19-13-11-9-8-10-12-18-48(69)61-39-26-28-66(29-27-39)40-24-25-43(46(30-40)74-5)63-55-59-33-42(57)52(65-55)62-44-16-14-15-17-47(44)75(6,7)73/h14-17,20-25,30,33,35,39,41,45,51,68H,8-13,18-19,26-29,31-32,34H2,1-7H3,(H,58,71)(H,61,69)(H,64,70)(H2,59,62,63,65)/t41-,45+,51-/m1/s1","YLHFCKVCYLEGIG-JSKJCRAUSA-N"
"523","Q9UM73","ALK","VHL","","SIAIS117","COC1=CC(N2CCC(NC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","7","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.7/46/259","Inhibit growth of SR/H2228/NCI-H1688 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1111.792","1110.50453008","9.49","77","7","14","6","24","220.11","C57H76ClN10O7PS","InChI=1S/C57H76ClN10O7PS/c1-37-51(77-36-61-37)39-23-21-38(22-24-39)33-59-54(72)46-32-42(69)35-68(46)55(73)52(57(2,3)4)65-50(71)20-14-12-10-8-9-11-13-19-49(70)62-40-27-29-67(30-28-40)41-25-26-44(47(31-41)75-5)64-56-60-34-43(58)53(66-56)63-45-17-15-16-18-48(45)76(6,7)74/h15-18,21-26,31,34,36,40,42,46,52,69H,8-14,19-20,27-30,32-33,35H2,1-7H3,(H,59,72)(H,62,70)(H,65,71)(H2,60,63,64,66)/t42-,46+,52-/m1/s1","DYUJLNPTOOBZBB-CCXZOALNSA-N"
"523","Q9UM73","ALK G1202R","VHL","","SIAIS117","COC1=CC(N2CCC(NC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<200","","Degradation of G1202R ALK in 293T cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","146.4","Inhibit growth of 293T cells expressing G1202R ALK","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1111.792","1110.50453008","9.49","77","7","14","6","24","220.11","C57H76ClN10O7PS","InChI=1S/C57H76ClN10O7PS/c1-37-51(77-36-61-37)39-23-21-38(22-24-39)33-59-54(72)46-32-42(69)35-68(46)55(73)52(57(2,3)4)65-50(71)20-14-12-10-8-9-11-13-19-49(70)62-40-27-29-67(30-28-40)41-25-26-44(47(31-41)75-5)64-56-60-34-43(58)53(66-56)63-45-17-15-16-18-48(45)76(6,7)74/h15-18,21-26,31,34,36,40,42,46,52,69H,8-14,19-20,27-30,32-33,35H2,1-7H3,(H,59,72)(H,62,70)(H,65,71)(H2,60,63,64,66)/t42-,46+,52-/m1/s1","DYUJLNPTOOBZBB-CCXZOALNSA-N"
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"525","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1096.737","1095.46847892","6.41","76","8","15","5","18","214.56","C55H71ClN11O7PS","InChI=1S/C55H71ClN11O7PS/c1-35-49(76-34-59-35)37-17-15-36(16-18-37)31-57-52(71)44-30-40(68)33-67(44)53(72)50(55(2,3)4)62-47(69)13-10-14-48(70)66-27-25-65(26-28-66)38-21-23-64(24-22-38)39-19-20-42(45(29-39)74-5)61-54-58-32-41(56)51(63-54)60-43-11-8-9-12-46(43)75(6,7)73/h8-9,11-12,15-20,29,32,34,38,40,44,50,68H,10,13-14,21-28,30-31,33H2,1-7H3,(H,57,71)(H,62,69)(H2,58,60,61,63)/t40-,44+,50-/m1/s1","DNSPIOOYGCWFFJ-PFPUJWRRSA-N"
"526","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1110.764","1109.48412899","6.77","77","8","15","5","19","214.56","C56H73ClN11O7PS","InChI=1S/C56H73ClN11O7PS/c1-36-50(77-35-60-36)38-18-16-37(17-19-38)32-58-53(72)45-31-41(69)34-68(45)54(73)51(56(2,3)4)63-48(70)14-10-11-15-49(71)67-28-26-66(27-29-67)39-22-24-65(25-23-39)40-20-21-43(46(30-40)75-5)62-55-59-33-42(57)52(64-55)61-44-12-8-9-13-47(44)76(6,7)74/h8-9,12-13,16-21,30,33,35,39,41,45,51,69H,10-11,14-15,22-29,31-32,34H2,1-7H3,(H,58,72)(H,63,70)(H2,59,61,62,64)/t41-,45+,51-/m1/s1","FGXYWCNXAJRXLB-JSKJCRAUSA-N"
"527","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1124.791","1123.49977905","7.31","78","8","15","5","20","214.56","C57H75ClN11O7PS","InChI=1S/C57H75ClN11O7PS/c1-37-51(78-36-61-37)39-19-17-38(18-20-39)33-59-54(73)46-32-42(70)35-69(46)55(74)52(57(2,3)4)64-49(71)15-9-8-10-16-50(72)68-29-27-67(28-30-68)40-23-25-66(26-24-40)41-21-22-44(47(31-41)76-5)63-56-60-34-43(58)53(65-56)62-45-13-11-12-14-48(45)77(6,7)75/h11-14,17-22,31,34,36,40,42,46,52,70H,8-10,15-16,23-30,32-33,35H2,1-7H3,(H,59,73)(H,64,71)(H2,60,62,63,65)/t42-,46+,52-/m1/s1","MGYRSTNWLZRDJG-CCXZOALNSA-N"
"528","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","11.4","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1138.818","1137.51542911","7.85","79","8","15","5","21","214.56","C58H77ClN11O7PS","InChI=1S/C58H77ClN11O7PS/c1-38-52(79-37-62-38)40-20-18-39(19-21-40)34-60-55(74)47-33-43(71)36-70(47)56(75)53(58(2,3)4)65-50(72)16-10-8-9-11-17-51(73)69-30-28-68(29-31-69)41-24-26-67(27-25-41)42-22-23-45(48(32-42)77-5)64-57-61-35-44(59)54(66-57)63-46-14-12-13-15-49(46)78(6,7)76/h12-15,18-23,32,35,37,41,43,47,53,71H,8-11,16-17,24-31,33-34,36H2,1-7H3,(H,60,74)(H,65,72)(H2,61,63,64,66)/t43-,47+,53-/m1/s1","LTPUWRULBUKGNI-LGIBPJQYSA-N"
"529","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","25.1","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1152.845","1151.53107918","8.4","80","8","15","5","22","214.56","C59H79ClN11O7PS","InChI=1S/C59H79ClN11O7PS/c1-39-53(80-38-63-39)41-21-19-40(20-22-41)35-61-56(75)48-34-44(72)37-71(48)57(76)54(59(2,3)4)66-51(73)17-11-9-8-10-12-18-52(74)70-31-29-69(30-32-70)42-25-27-68(28-26-42)43-23-24-46(49(33-43)78-5)65-58-62-36-45(60)55(67-58)64-47-15-13-14-16-50(47)79(6,7)77/h13-16,19-24,33,36,38,42,44,48,54,72H,8-12,17-18,25-32,34-35,37H2,1-7H3,(H,61,75)(H,66,73)(H2,62,64,65,67)/t44-,48+,54-/m1/s1","GONDMTIOPVKJJM-IEUXFAQDSA-N"
"530","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","7.5","","Degradation of ALK in SR cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1166.872","1165.54672924","8.94","81","8","15","5","23","214.56","C60H81ClN11O7PS","InChI=1S/C60H81ClN11O7PS/c1-40-54(81-39-64-40)42-22-20-41(21-23-42)36-62-57(76)49-35-45(73)38-72(49)58(77)55(60(2,3)4)67-52(74)18-12-10-8-9-11-13-19-53(75)71-32-30-70(31-33-71)43-26-28-69(29-27-43)44-24-25-47(50(34-44)79-5)66-59-63-37-46(61)56(68-59)65-48-16-14-15-17-51(48)80(6,7)78/h14-17,20-25,34,37,39,43,45,49,55,73H,8-13,18-19,26-33,35-36,38H2,1-7H3,(H,62,76)(H,67,74)(H2,63,65,66,68)/t45-,49+,55-/m1/s1","ZRZMJGXWXYTWKE-JVPKQGNTSA-N"
"531","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1087.682","1086.43175907","5.17","75","7","16","5","22","229.78","C53H68ClN10O9PS","InChI=1S/C53H68ClN10O9PS/c1-34-47(75-33-57-34)36-14-12-35(13-15-36)30-55-50(68)42-29-38(65)32-64(42)51(69)48(53(2,3)4)60-45(66)18-24-72-26-27-73-25-19-46(67)63-22-20-62(21-23-63)37-16-17-40(43(28-37)71-5)59-52-56-31-39(54)49(61-52)58-41-10-8-9-11-44(41)74(6,7)70/h8-17,28,31,33,38,42,48,65H,18-27,29-30,32H2,1-7H3,(H,55,68)(H,60,66)(H2,56,58,59,61)/t38-,42+,48-/m1/s1","JPRLEZWABUIUJK-AQHSYVBPSA-N"
"532","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1131.735","1130.45797381","5.02","78","7","17","5","25","239.01","C55H72ClN10O10PS","InChI=1S/C55H72ClN10O10PS/c1-36-49(78-35-59-36)38-14-12-37(13-15-38)32-57-52(70)44-31-40(67)34-66(44)53(71)50(55(2,3)4)62-47(68)18-24-74-26-28-76-29-27-75-25-19-48(69)65-22-20-64(21-23-65)39-16-17-42(45(30-39)73-5)61-54-58-33-41(56)51(63-54)60-43-10-8-9-11-46(43)77(6,7)72/h8-17,30,33,35,40,44,50,67H,18-29,31-32,34H2,1-7H3,(H,57,70)(H,62,68)(H2,58,60,61,63)/t40-,44+,50-/m1/s1","NWDVFGIJHFQTNQ-PFPUJWRRSA-N"
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"534","Q9UM73","ALK","VHL","","","COC1=CC(N2CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1219.841","1218.51040331","4.73","84","7","19","5","31","257.47","C59H80ClN10O12PS","InChI=1S/C59H80ClN10O12PS/c1-40-53(84-39-63-40)42-14-12-41(13-15-42)36-61-56(74)48-35-44(71)38-70(48)57(75)54(59(2,3)4)66-51(72)18-24-78-26-28-80-30-32-82-33-31-81-29-27-79-25-19-52(73)69-22-20-68(21-23-69)43-16-17-46(49(34-43)77-5)65-58-62-37-45(60)55(67-58)64-47-10-8-9-11-50(47)83(6,7)76/h8-17,34,37,39,44,48,54,71H,18-33,35-36,38H2,1-7H3,(H,61,74)(H,66,72)(H2,62,64,65,67)/t44-,48+,54-/m1/s1","ZOSITVKJCLXROG-IEUXFAQDSA-N"
"535","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1101.709","1100.44740913","5.77","76","7","16","6","23","238.57","C54H70ClN10O9PS","InChI=1S/C54H70ClN10O9PS/c1-34-48(76-33-58-34)36-14-12-35(13-15-36)30-56-51(69)43-29-39(66)32-65(43)52(70)49(54(2,3)4)62-47(68)21-25-74-27-26-73-24-20-46(67)59-37-18-22-64(23-19-37)38-16-17-41(44(28-38)72-5)61-53-57-31-40(55)50(63-53)60-42-10-8-9-11-45(42)75(6,7)71/h8-17,28,31,33,37,39,43,49,66H,18-27,29-30,32H2,1-7H3,(H,56,69)(H,59,67)(H,62,68)(H2,57,60,61,63)/t39-,43+,49-/m1/s1","UHSGCWSUTSJDCQ-SHTJZPIOSA-N"
"536","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1145.762","1144.47362388","5.62","79","7","17","6","26","247.8","C56H74ClN10O10PS","InChI=1S/C56H74ClN10O10PS/c1-36-50(79-35-60-36)38-14-12-37(13-15-38)32-58-53(71)45-31-41(68)34-67(45)54(72)51(56(2,3)4)64-49(70)21-25-76-27-29-77-28-26-75-24-20-48(69)61-39-18-22-66(23-19-39)40-16-17-43(46(30-40)74-5)63-55-59-33-42(57)52(65-55)62-44-10-8-9-11-47(44)78(6,7)73/h8-17,30,33,35,39,41,45,51,68H,18-29,31-32,34H2,1-7H3,(H,58,71)(H,61,69)(H,64,70)(H2,59,62,63,65)/t41-,45+,51-/m1/s1","NTSOPPVKCGKEEN-JSKJCRAUSA-N"
"537","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1189.815","1188.49983863","5.47","82","7","18","6","29","257.03","C58H78ClN10O11PS","InChI=1S/C58H78ClN10O11PS/c1-38-52(82-37-62-38)40-14-12-39(13-15-40)34-60-55(73)47-33-43(70)36-69(47)56(74)53(58(2,3)4)66-51(72)21-25-78-27-29-80-31-30-79-28-26-77-24-20-50(71)63-41-18-22-68(23-19-41)42-16-17-45(48(32-42)76-5)65-57-61-35-44(59)54(67-57)64-46-10-8-9-11-49(46)81(6,7)75/h8-17,32,35,37,41,43,47,53,70H,18-31,33-34,36H2,1-7H3,(H,60,73)(H,63,71)(H,66,72)(H2,61,64,65,67)/t43-,47+,53-/m1/s1","DQMAXRITQMDFOY-LGIBPJQYSA-N"
"538","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(NC(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1233.868","1232.52605337","5.32","85","7","19","6","32","266.26","C60H82ClN10O12PS","InChI=1S/C60H82ClN10O12PS/c1-40-54(85-39-64-40)42-14-12-41(13-15-42)36-62-57(75)49-35-45(72)38-71(49)58(76)55(60(2,3)4)68-53(74)21-25-80-27-29-82-31-33-83-32-30-81-28-26-79-24-20-52(73)65-43-18-22-70(23-19-43)44-16-17-47(50(34-44)78-5)67-59-63-37-46(61)56(69-59)66-48-10-8-9-11-51(48)84(6,7)77/h8-17,34,37,39,43,45,49,55,72H,18-33,35-36,38H2,1-7H3,(H,62,75)(H,65,73)(H,68,74)(H2,63,66,67,69)/t45-,49+,55-/m1/s1","LRVCOAXWUJJRLZ-JVPKQGNTSA-N"
"539","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1170.816","1169.50525835","5.76","81","8","17","5","23","233.02","C58H77ClN11O9PS","InChI=1S/C58H77ClN11O9PS/c1-38-52(81-37-62-38)40-14-12-39(13-15-40)34-60-55(74)47-33-43(71)36-70(47)56(75)53(58(2,3)4)65-50(72)20-28-78-30-31-79-29-21-51(73)69-26-24-68(25-27-69)41-18-22-67(23-19-41)42-16-17-45(48(32-42)77-5)64-57-61-35-44(59)54(66-57)63-46-10-8-9-11-49(46)80(6,7)76/h8-17,32,35,37,41,43,47,53,71H,18-31,33-34,36H2,1-7H3,(H,60,74)(H,65,72)(H2,61,63,64,66)/t43-,47+,53-/m1/s1","AJWZHGGSHNNEJE-LGIBPJQYSA-N"
"540","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1214.869","1213.5314731","5.61","84","8","18","5","26","242.25","C60H81ClN11O10PS","InChI=1S/C60H81ClN11O10PS/c1-40-54(84-39-64-40)42-14-12-41(13-15-42)36-62-57(76)49-35-45(73)38-72(49)58(77)55(60(2,3)4)67-52(74)20-28-80-30-32-82-33-31-81-29-21-53(75)71-26-24-70(25-27-71)43-18-22-69(23-19-43)44-16-17-47(50(34-44)79-5)66-59-63-37-46(61)56(68-59)65-48-10-8-9-11-51(48)83(6,7)78/h8-17,34,37,39,43,45,49,55,73H,18-33,35-36,38H2,1-7H3,(H,62,76)(H,67,74)(H2,63,65,66,68)/t45-,49+,55-/m1/s1","SRDHDYDEUTWJCT-JVPKQGNTSA-N"
"541","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1258.922","1257.55768785","5.47","87","8","19","5","29","251.48","C62H85ClN11O11PS","InChI=1S/C62H85ClN11O11PS/c1-42-56(87-41-66-42)44-14-12-43(13-15-44)38-64-59(78)51-37-47(75)40-74(51)60(79)57(62(2,3)4)69-54(76)20-28-82-30-32-84-34-35-85-33-31-83-29-21-55(77)73-26-24-72(25-27-73)45-18-22-71(23-19-45)46-16-17-49(52(36-46)81-5)68-61-65-39-48(63)58(70-61)67-50-10-8-9-11-53(50)86(6,7)80/h8-17,36,39,41,45,47,51,57,75H,18-35,37-38,40H2,1-7H3,(H,64,78)(H,69,76)(H2,65,67,68,70)/t47-,51+,57-/m1/s1","NHKGIYHEGWJCSC-NSONYEDRSA-N"
"542","Q9UM73","ALK","VHL","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112190","1302.975","1301.5839026","5.32","90","8","20","5","32","260.71","C64H89ClN11O12PS","InChI=1S/C64H89ClN11O12PS/c1-44-58(90-43-68-44)46-14-12-45(13-15-46)40-66-61(80)53-39-49(77)42-76(53)62(81)59(64(2,3)4)71-56(78)20-28-84-30-32-86-34-36-88-37-35-87-33-31-85-29-21-57(79)75-26-24-74(25-27-75)47-18-22-73(23-19-47)48-16-17-51(54(38-48)83-5)70-63-67-41-50(65)60(72-63)69-52-10-8-9-11-55(52)89(6,7)82/h8-17,38,41,43,47,49,53,59,77H,18-37,39-40,42H2,1-7H3,(H,66,80)(H,71,78)(H2,67,69,70,72)/t49-,53+,59-/m1/s1","IOEDPVOCHUFGRR-MPZHPWTRSA-N"
"543","O14965","AURKA","CRBN","","TL13-12","COC1=CC(N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","","","","","","13.5","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","1200","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.3/2.6/95","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","961.499","960.335536576","4.56","67","7","17","5","21","242.83","C45H53ClN10O10S","InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)","WXNUIPVZMJMPNM-UHFFFAOYSA-N"
"543","Q05397","FAK","CRBN","","TL13-12","COC1=CC(N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","","","","","","26.6","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","1200","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.3/2.6/95","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","961.499","960.335536576","4.56","67","7","17","5","21","242.83","C45H53ClN10O10S","InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)","WXNUIPVZMJMPNM-UHFFFAOYSA-N"
"543","P16591","FER","CRBN","","TL13-12","COC1=CC(N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","","","","","","8.95","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","1200","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.3/2.6/95","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","961.499","960.335536576","4.56","67","7","17","5","21","242.83","C45H53ClN10O10S","InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)","WXNUIPVZMJMPNM-UHFFFAOYSA-N"
"543","Q15418","RPS6KA1","CRBN","","TL13-12","COC1=CC(N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","","","","","","115","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","1200","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.3/2.6/95","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","961.499","960.335536576","4.56","67","7","17","5","21","242.83","C45H53ClN10O10S","InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)","WXNUIPVZMJMPNM-UHFFFAOYSA-N"
"543","Q9UM73","ALK","CRBN","","TL13-12","COC1=CC(N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","10/180/50","","Degradation of ALK in H3122/Karpas 299/Kelly cells 16 h treatment","","","0.69","Inhibition of ALK by TR-FRET ALK activity assay","","","","","","","","","","","","","","","1200","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.3/2.6/95","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","961.499","960.335536576","4.56","67","7","17","5","21","242.83","C45H53ClN10O10S","InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53)","WXNUIPVZMJMPNM-UHFFFAOYSA-N"
"544","O14965","AURKA","CRBN","","TL13-112","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","8550","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","2400","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.4/9.2/374","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","1002.592","1001.3872378","6.37","70","7","16","5","22","239.59","C49H60ClN9O10S","InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)","XIRQUXILNXIWDI-UHFFFAOYSA-N"
"544","Q05397","FAK","CRBN","","TL13-112","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","25.4","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","2400","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.4/9.2/374","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","1002.592","1001.3872378","6.37","70","7","16","5","22","239.59","C49H60ClN9O10S","InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)","XIRQUXILNXIWDI-UHFFFAOYSA-N"
"544","P16591","FER","CRBN","","TL13-112","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","42.4","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","2400","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.4/9.2/374","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","1002.592","1001.3872378","6.37","70","7","16","5","22","239.59","C49H60ClN9O10S","InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)","XIRQUXILNXIWDI-UHFFFAOYSA-N"
"544","Q15418","RPS6KA1","CRBN","","TL13-112","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","677","IC50 was assessed by Z'LYTE Assay","","","","","","","","","","","","","","","2400","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.4/9.2/374","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","1002.592","1001.3872378","6.37","70","7","16","5","22","239.59","C49H60ClN9O10S","InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)","XIRQUXILNXIWDI-UHFFFAOYSA-N"
"544","Q9UM73","ALK","CRBN","","TL13-112","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCOCCOCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","10/40/50","","Degradation of ALK in H3122/Karpas 299/Kelly cells 16 h treatment","","","0.6","Inhibition of ALK by TR-FRET ALK activity assay","","","","","","","","","","","","","","","2400","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.4/9.2/374","Inhibit proliferation of H3122/Karpas 299/Kelly cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b01655","1002.592","1001.3872378","6.37","70","7","16","5","22","239.59","C49H60ClN9O10S","InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)","XIRQUXILNXIWDI-UHFFFAOYSA-N"
"545","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","901.892","900.31688868","7.16","64","8","7","1","8","131.93","C50H50Cl2N6O6","InChI=1S/C50H50Cl2N6O6/c1-5-64-41-29-34(50(2,3)4)17-22-38(41)46-54-44(32-13-18-35(51)19-14-32)45(33-15-20-36(52)21-16-33)58(46)49(63)56-27-25-55(26-28-56)43(60)12-7-6-9-31-10-8-11-37-39(31)30-57(48(37)62)40-23-24-42(59)53-47(40)61/h8,10-11,13-22,29,40,44-45H,5,7,12,23-28,30H2,1-4H3,(H,53,59,61)","SSAVNUNRQAALLH-UHFFFAOYSA-N"
"546","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","915.919","914.332538744","7.52","65","8","7","1","9","131.93","C51H52Cl2N6O6","InChI=1S/C51H52Cl2N6O6/c1-5-65-42-30-35(51(2,3)4)18-23-39(42)47-55-45(33-14-19-36(52)20-15-33)46(34-16-21-37(53)22-17-34)59(47)50(64)57-28-26-56(27-29-57)44(61)13-8-6-7-10-32-11-9-12-38-40(32)31-58(49(38)63)41-24-25-43(60)54-48(41)62/h9,11-12,14-23,30,41,45-46H,5-6,8,13,24-29,31H2,1-4H3,(H,54,60,62)","ZREKDJMGBXRMRH-UHFFFAOYSA-N"
"547","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","929.946","928.348188808","8.06","66","8","7","1","10","131.93","C52H54Cl2N6O6","InChI=1S/C52H54Cl2N6O6/c1-5-66-43-31-36(52(2,3)4)19-24-40(43)48-56-46(34-15-20-37(53)21-16-34)47(35-17-22-38(54)23-18-35)60(48)51(65)58-29-27-57(28-30-58)45(62)14-9-7-6-8-11-33-12-10-13-39-41(33)32-59(50(39)64)42-25-26-44(61)55-49(42)63/h10,12-13,15-24,31,42,46-47H,5-7,9,14,25-30,32H2,1-4H3,(H,55,61,63)","XUHAJDPJTMKEEY-UHFFFAOYSA-N"
"548","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CNC(=O)CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","958.944","957.338352396","6.51","68","8","8","2","10","161.03","C52H53Cl2N7O7","InChI=1S/C52H53Cl2N7O7/c1-5-68-42-29-35(52(2,3)4)17-22-39(42)48-57-46(33-13-18-36(53)19-14-33)47(34-15-20-37(54)21-16-34)61(48)51(67)59-27-25-58(26-28-59)45(64)30-55-43(62)12-7-6-9-32-10-8-11-38-40(32)31-60(50(38)66)41-23-24-44(63)56-49(41)65/h8,10-11,13-22,29,41,46-47H,5,7,12,23-28,30-31H2,1-4H3,(H,55,62)(H,56,63,65)","DXACSDQDHFPEDF-UHFFFAOYSA-N"
"549","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CNC(=O)CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","972.971","971.35400246","6.86","69","8","8","2","11","161.03","C53H55Cl2N7O7","InChI=1S/C53H55Cl2N7O7/c1-5-69-43-30-36(53(2,3)4)18-23-40(43)49-58-47(34-14-19-37(54)20-15-34)48(35-16-21-38(55)22-17-35)62(49)52(68)60-28-26-59(27-29-60)46(65)31-56-44(63)13-8-6-7-10-33-11-9-12-39-41(33)32-61(51(39)67)42-24-25-45(64)57-50(42)66/h9,11-12,14-23,30,42,47-48H,5-6,8,13,24-29,31-32H2,1-4H3,(H,56,63)(H,57,64,66)","MRDNCCKFZSDMNU-UHFFFAOYSA-N"
"550","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CNC(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","986.998","985.369652524","7.4","70","8","8","2","12","161.03","C54H57Cl2N7O7","InChI=1S/C54H57Cl2N7O7/c1-5-70-44-31-37(54(2,3)4)19-24-41(44)50-59-48(35-15-20-38(55)21-16-35)49(36-17-22-39(56)23-18-36)63(50)53(69)61-29-27-60(28-30-61)47(66)32-57-45(64)14-9-7-6-8-11-34-12-10-13-40-42(34)33-62(52(40)68)43-25-26-46(65)58-51(43)67/h10,12-13,15-24,31,43,48-49H,5-7,9,14,25-30,32-33H2,1-4H3,(H,57,64)(H,58,65,67)","VWMGGNJPYLHXEB-UHFFFAOYSA-N"
"551","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.2","Inhibit proliferation of RS4; 11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","859.855","858.306323996","7.3","61","8","7","1","7","114.86","C48H48Cl2N6O5","InChI=1S/C48H48Cl2N6O5/c1-5-61-40-28-33(48(2,3)4)15-20-37(40)44-52-42(31-11-16-34(49)17-12-31)43(32-13-18-35(50)19-14-32)56(44)47(60)54-26-24-53(25-27-54)23-7-9-30-8-6-10-36-38(30)29-55(46(36)59)39-21-22-41(57)51-45(39)58/h6,8,10-20,28,39,42-43H,5,21-27,29H2,1-4H3,(H,51,57,58)","SXPSRFOBNYZXKH-UHFFFAOYSA-N"
"552","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","873.882","872.32197406","7.77","62","8","7","1","8","114.86","C49H50Cl2N6O5","InChI=1S/C49H50Cl2N6O5/c1-5-62-41-29-34(49(2,3)4)16-21-38(41)45-53-43(32-12-17-35(50)18-13-32)44(33-14-19-36(51)20-15-33)57(45)48(61)55-27-25-54(26-28-55)24-7-6-9-31-10-8-11-37-39(31)30-56(47(37)60)40-22-23-42(58)52-46(40)59/h8,10-21,29,40,43-44H,5,7,22-28,30H2,1-4H3,(H,52,58,59)","ABQLUXPVSUFYLP-UHFFFAOYSA-N"
"553","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","887.909","886.337624124","8.12","63","8","7","1","9","114.86","C50H52Cl2N6O5","InChI=1S/C50H52Cl2N6O5/c1-5-63-42-30-35(50(2,3)4)17-22-39(42)46-54-44(33-13-18-36(51)19-14-33)45(34-15-20-37(52)21-16-34)58(46)49(62)56-28-26-55(27-29-56)25-8-6-7-10-32-11-9-12-38-40(32)31-57(48(38)61)41-23-24-43(59)53-47(41)60/h9,11-22,30,41,44-45H,5-6,8,23-29,31H2,1-4H3,(H,53,59,60)","LFRWWRZDEALWEY-UHFFFAOYSA-N"
"554","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","821.806","820.290673932","7.2","58","8","7","1","7","114.86","C45H46Cl2N6O5","InChI=1S/C45H46Cl2N6O5/c1-5-58-37-25-29(45(2,3)4)13-18-33(37)41-49-39(27-9-14-30(46)15-10-27)40(28-11-16-31(47)17-12-28)53(41)44(57)51-23-21-50(22-24-51)35-8-6-7-32-34(35)26-52(43(32)56)36-19-20-38(54)48-42(36)55/h6-18,25,36,39-40H,5,19-24,26H2,1-4H3,(H,48,54,55)","KNSUOKNBVZOJBO-UHFFFAOYSA-N"
"555","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","878.858","877.312137648","6.59","62","8","8","2","9","143.96","C47H49Cl2N7O6","InChI=1S/C47H49Cl2N7O6/c1-5-62-38-25-30(47(2,3)4)13-18-34(38)43-52-41(28-9-14-31(48)15-10-28)42(29-11-16-32(49)17-12-29)56(43)46(61)54-23-21-53(22-24-54)40(58)26-50-36-8-6-7-33-35(36)27-55(45(33)60)37-19-20-39(57)51-44(37)59/h6-18,25,37,41-42,50H,5,19-24,26-27H2,1-4H3,(H,51,57,59)","QYCJKXDDSKZHAH-UHFFFAOYSA-N"
"556","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@H](C2=CC=C(Cl)C=C2)[C@@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","23","90","Degradation of MDM2 in RS4; 11 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.2","Inhibit proliferation of RS4; 11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","859.855","858.306323996","7.3","61","8","7","1","7","114.86","C48H48Cl2N6O5","InChI=1S/C48H48Cl2N6O5/c1-5-61-40-28-33(48(2,3)4)15-20-37(40)44-52-42(31-11-16-34(49)17-12-31)43(32-13-18-35(50)19-14-32)56(44)47(60)54-26-24-53(25-27-54)23-7-9-30-8-6-10-36-38(30)29-55(46(36)59)39-21-22-41(57)51-45(39)58/h6,8,10-20,28,39,42-43H,5,21-27,29H2,1-4H3,(H,51,57,58)/t39?,42-,43+/m0/s1","SXPSRFOBNYZXKH-UZLVNVLGSA-N"
"557","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@H](C2=CC=C(Cl)C=C2)[C@@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","873.882","872.32197406","7.77","62","8","7","1","8","114.86","C49H50Cl2N6O5","InChI=1S/C49H50Cl2N6O5/c1-5-62-41-29-34(49(2,3)4)16-21-38(41)45-53-43(32-12-17-35(50)18-13-32)44(33-14-19-36(51)20-15-33)57(45)48(61)55-27-25-54(26-28-55)24-7-6-9-31-10-8-11-37-39(31)30-56(47(37)60)40-22-23-42(58)52-46(40)59/h8,10-21,29,40,43-44H,5,7,22-28,30H2,1-4H3,(H,52,58,59)/t40?,43-,44+/m0/s1","ABQLUXPVSUFYLP-BWNMLRSQSA-N"
"558","Q00987","MDM2","CRBN","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@H](C2=CC=C(Cl)C=C2)[C@@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.05.046","887.909","886.337624124","8.12","63","8","7","1","9","114.86","C50H52Cl2N6O5","InChI=1S/C50H52Cl2N6O5/c1-5-63-42-30-35(50(2,3)4)17-22-39(42)46-54-44(33-13-18-36(51)19-14-33)45(34-15-20-37(52)21-16-34)58(46)49(62)56-28-26-55(27-29-56)25-8-6-7-10-32-11-9-12-38-40(32)31-57(48(38)61)41-23-24-43(59)53-47(41)60/h9,11-22,30,41,44-45H,5-6,8,23-29,31H2,1-4H3,(H,53,59,60)/t41?,44-,45+/m0/s1","LFRWWRZDEALWEY-HKHHIWETSA-N"
"559","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCN4CCN(C5=CC=C(NC6=CC7=C(N8CCC(CO)CC8)N=C(NC8=CC=C(F)C=C8)N=C7C=N6)N=C5)CC4)C=CC=C3C2=O)C(=O)N1","45.2","87","Degradation of EGFR in HCC827 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","180","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","913.072","912.455891144","5.26","67","9","14","5","17","201.15","C49H57FN12O5","InChI=1S/C49H57FN12O5/c50-33-10-12-34(13-11-33)53-49-55-40-29-52-43(27-37(40)46(58-49)61-21-18-32(31-63)19-22-61)56-42-16-14-35(28-51-42)60-25-23-59(24-26-60)20-5-3-1-2-4-9-44(64)54-39-8-6-7-36-38(39)30-62(48(36)67)41-15-17-45(65)57-47(41)66/h6-8,10-14,16,27-29,32,41,63H,1-5,9,15,17-26,30-31H2,(H,54,64)(H,51,52,56)(H,53,55,58)(H,57,65,66)","ZWLPWTDAYPOQGR-UHFFFAOYSA-N"
"560","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCN4CCN(C5=CC=C(NC6=CC7=C(N8CCC(CO)CC8)N=C(NC8=CC=C(F)C=C8)N=C7C=N6)N=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1210","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","899.045","898.44024108","4.71","66","9","14","5","16","201.15","C48H55FN12O5","InChI=1S/C48H55FN12O5/c49-32-9-11-33(12-10-32)52-48-54-39-28-51-42(26-36(39)45(57-48)60-20-17-31(30-62)18-21-60)55-41-15-13-34(27-50-41)59-24-22-58(23-25-59)19-4-2-1-3-8-43(63)53-38-7-5-6-35-37(38)29-61(47(35)66)40-14-16-44(64)56-46(40)65/h5-7,9-13,15,26-28,31,40,62H,1-4,8,14,16-25,29-30H2,(H,53,63)(H,50,51,55)(H,52,54,57)(H,56,64,65)","FFVKASNNDQLIDU-UHFFFAOYSA-N"
"561","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCN4CCN(C5=CC=C(NC6=CC7=C(N8CCC(CO)CC8)N=C(NC8=CC=C(F)C=C8)N=C7C=N6)N=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","885.018","884.424591016","4.17","65","9","14","5","15","201.15","C47H53FN12O5","InChI=1S/C47H53FN12O5/c48-31-8-10-32(11-9-31)51-47-53-38-27-50-41(25-35(38)44(56-47)59-19-16-30(29-61)17-20-59)54-40-14-12-33(26-49-40)58-23-21-57(22-24-58)18-3-1-2-7-42(62)52-37-6-4-5-34-36(37)28-60(46(34)65)39-13-15-43(63)55-45(39)64/h4-6,8-12,14,25-27,30,39,61H,1-3,7,13,15-24,28-29H2,(H,52,62)(H,49,50,54)(H,51,53,56)(H,55,63,64)","ODJQZPLMAOELRA-UHFFFAOYSA-N"
"562","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCN4CCN(C5=CC=C(NC6=CC7=C(N8CCC(CO)CC8)N=C(NC8=CC=C(F)C=C8)N=C7C=N6)N=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","870.991","870.408940952","3.82","64","9","14","5","14","201.15","C46H51FN12O5","InChI=1S/C46H51FN12O5/c47-30-7-9-31(10-8-30)50-46-52-37-26-49-40(24-34(37)43(55-46)58-18-15-29(28-60)16-19-58)53-39-13-11-32(25-48-39)57-22-20-56(21-23-57)17-2-1-6-41(61)51-36-5-3-4-33-35(36)27-59(45(33)64)38-12-14-42(62)54-44(38)63/h3-5,7-11,13,24-26,29,38,60H,1-2,6,12,14-23,27-28H2,(H,51,61)(H,48,49,53)(H,50,52,55)(H,54,62,63)","ZLQKFKXUGYUHGE-UHFFFAOYSA-N"
"563","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCN4C=C(CN5CCN(C6=CC=C(NC7=CC8=C(N9CCC(CO)CC9)N=C(NC9=CC=C(F)C=C9)N=C8C=N7)N=C6)CC5)N=N4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7910","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","994.15","993.48858824","4.49","73","10","17","5","19","231.86","C52H60FN15O5","InChI=1S/C52H60FN15O5/c53-35-10-12-36(13-11-35)56-52-58-43-29-55-46(27-40(43)49(61-52)66-21-18-34(33-69)19-22-66)59-45-16-14-38(28-54-45)65-25-23-64(24-26-65)30-37-31-67(63-62-37)20-5-3-1-2-4-9-47(70)57-42-8-6-7-39-41(42)32-68(51(39)73)44-15-17-48(71)60-50(44)72/h6-8,10-14,16,27-29,31,34,44,69H,1-5,9,15,17-26,30,32-33H2,(H,57,70)(H,54,55,59)(H,56,58,61)(H,60,71,72)","YGIUVVAIJWPSDA-UHFFFAOYSA-N"
"564","P00533","EGFR","CRBN","","","O=C(CN1CCN(C2=CC=C(NC3=CC4=C(N5CCC(CO)CC5)N=C(NC5=CC=C(F)C=C5)N=C4C=N3)N=C2)CC1)NCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2760","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","899.989","899.39910454","2.45","66","9","15","6","14","230.25","C46H50FN13O6","InChI=1S/C46H50FN13O6/c47-29-4-6-30(7-5-29)51-46-53-36-24-50-39(22-33(36)43(56-46)59-16-13-28(27-61)14-17-59)54-38-10-8-31(23-49-38)58-20-18-57(19-21-58)26-42(64)48-15-12-41(63)52-35-3-1-2-32-34(35)25-60(45(32)66)37-9-11-40(62)55-44(37)65/h1-8,10,22-24,28,37,61H,9,11-21,25-27H2,(H,48,64)(H,52,63)(H,49,50,54)(H,51,53,56)(H,55,62,65)","BJYUZUZKGOOWHB-UHFFFAOYSA-N"
"565","P00533","EGFR","CRBN","","","CN(C)C1CCN(C2=CC=C(NC3=CC4=C(N5CCN(CCCCCCCC(=O)NC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)N=C(NC5=CC=C(F)C=C5)N=C4C=N3)N=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1450","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","926.115","925.48752562","5.79","68","9","14","4","17","184.16","C50H60FN13O4","InChI=1S/C50H60FN13O4/c1-60(2)35-20-23-62(24-21-35)36-16-18-43(52-30-36)57-44-29-38-41(31-53-44)56-50(54-34-14-12-33(51)13-15-34)59-47(38)63-27-25-61(26-28-63)22-7-5-3-4-6-11-45(65)55-40-10-8-9-37-39(40)32-64(49(37)68)42-17-19-46(66)58-48(42)67/h8-10,12-16,18,29-31,35,42H,3-7,11,17,19-28,32H2,1-2H3,(H,55,65)(H,52,53,57)(H,54,56,59)(H,58,66,67)","JWIJDEAEELQGIY-UHFFFAOYSA-N"
"566","P00533","EGFR","CRBN","","","CN(C)C1CCN(C2=CC=C(NC3=CC4=C(N5CCN(CC(=O)NCCC(=O)NC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)N=C(NC5=CC=C(F)C=C5)N=C4C=N3)N=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4630","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","913.032","912.430739016","2.98","67","9","15","5","14","213.26","C47H53FN14O5","InChI=1S/C47H53FN14O5/c1-58(2)31-15-18-60(19-16-31)32-10-12-39(50-25-32)55-40-24-34-37(26-51-40)54-47(52-30-8-6-29(48)7-9-30)57-44(34)61-22-20-59(21-23-61)28-43(65)49-17-14-42(64)53-36-5-3-4-33-35(36)27-62(46(33)67)38-11-13-41(63)56-45(38)66/h3-10,12,24-26,31,38H,11,13-23,27-28H2,1-2H3,(H,49,65)(H,53,64)(H,50,51,55)(H,52,54,57)(H,56,63,66)","GUZCGEKRDGMCQI-UHFFFAOYSA-N"
"567","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN3CCN(C4=CC=C(NC5=CC6=C(N7CCC(CO)CC7)N=C(NC7=CC=C(F)C=C7)N=C6C=N5)N=C4)CC3)C(C)(C)C)C=C2)SC=N1","34.8","98","Degradation of EGFR in HCC827 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","220","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","1070.354","1069.54841162","7.67","77","9","16","6","20","217.2","C57H72FN13O5S","InChI=1S/C57H72FN13O5S/c1-37-51(77-36-62-37)40-12-10-38(11-13-40)31-61-54(75)47-29-44(73)34-71(47)55(76)52(57(2,3)4)66-50(74)9-7-5-6-8-22-68-25-27-69(28-26-68)43-18-19-48(59-32-43)65-49-30-45-46(33-60-49)64-56(63-42-16-14-41(58)15-17-42)67-53(45)70-23-20-39(35-72)21-24-70/h10-19,30,32-33,36,39,44,47,52,72-73H,5-9,20-29,31,34-35H2,1-4H3,(H,61,75)(H,66,74)(H,59,60,65)(H,63,64,67)/t44-,47+,52-/m1/s1","LCTCXOPSLJEXKE-FEDPBZRBSA-N"
"568","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCN3CCN(C4=CC=C(NC5=CC6=C(N7CCC(CO)CC7)N=C(NC7=CC=C(F)C=C7)N=C6C=N5)N=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1490","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","1042.3","1041.5171115","6.77","75","9","16","6","18","217.2","C55H68FN13O5S","InChI=1S/C55H68FN13O5S/c1-35-49(75-34-60-35)38-10-8-36(9-11-38)29-59-52(73)45-27-42(71)32-69(45)53(74)50(55(2,3)4)64-48(72)7-5-6-20-66-23-25-67(26-24-66)41-16-17-46(57-30-41)63-47-28-43-44(31-58-47)62-54(61-40-14-12-39(56)13-15-40)65-51(43)68-21-18-37(33-70)19-22-68/h8-17,28,30-31,34,37,42,45,50,70-71H,5-7,18-27,29,32-33H2,1-4H3,(H,59,73)(H,64,72)(H,57,58,63)(H,61,62,65)/t42-,45+,50-/m1/s1","DBOZEYKAOPNYFQ-YPPXMBQWSA-N"
"569","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCN3CCN(C4=CC=C(NC5=CC6=C(N7CCC(CO)CC7)N=C(NC7=CC=C(F)C=C7)N=C6C=N5)N=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","710/6390/2320","Inhibit proliferation of HCC827/A549/A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","1118.395","1117.56954099","5.93","80","9","19","6","25","227.82","C58H76FN13O7S","InChI=1S/C58H76FN13O7S/c1-39-52(80-38-64-39)42-7-5-40(6-8-42)33-63-55(75)49-31-46(74)36-72(49)56(76)53(58(2,3)4)60-17-25-77-27-29-79-30-28-78-26-24-69-20-22-70(23-21-69)45-13-14-50(61-34-45)67-51-32-47-48(35-62-51)66-57(65-44-11-9-43(59)10-12-44)68-54(47)71-18-15-41(37-73)16-19-71/h5-14,32,34-35,38,41,46,49,53,60,73-74H,15-31,33,36-37H2,1-4H3,(H,63,75)(H,61,62,67)(H,65,66,68)/t46-,49+,53-/m1/s1","FFHRIJQREBDIFV-XYNMIOBWSA-N"
"570","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCN3CCN(C4=CC=C(NC5=CC6=C(N7CCC(CO)CC7)N=C(NC7=CC=C(F)C=C7)N=C6C=N5)N=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","340/2460","Inhibit proliferation of HCC827/A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","1074.342","1073.54332624","6.08","77","9","18","6","22","218.59","C56H72FN13O6S","InChI=1S/C56H72FN13O6S/c1-37-50(77-36-62-37)40-7-5-38(6-8-40)31-61-53(73)47-29-44(72)34-70(47)54(74)51(56(2,3)4)58-17-25-75-27-28-76-26-24-67-20-22-68(23-21-67)43-13-14-48(59-32-43)65-49-30-45-46(33-60-49)64-55(63-42-11-9-41(57)10-12-42)66-52(45)69-18-15-39(35-71)16-19-69/h5-14,30,32-33,36,39,44,47,51,58,71-72H,15-29,31,34-35H2,1-4H3,(H,61,73)(H,59,60,65)(H,63,64,66)/t44-,47+,51-/m1/s1","CQUCWGCCDVGZNK-SRLHMHSXSA-N"
"571","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCN3C=C(CN4CCN(C5=CC=C(NC6=CC7=C(N8CCC(CO)CC8)N=C(NC8=CC=C(F)C=C8)N=C7C=N6)N=C5)CC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1760","Inhibit proliferation of HCC827 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112061","1155.42","1154.57602334","5.31","83","10","21","6","24","249.3","C59H75FN16O6S","InChI=1S/C59H75FN16O6S/c1-39-53(83-38-65-39)42-7-5-40(6-8-42)31-64-56(79)50-29-47(78)36-76(50)57(80)54(59(2,3)4)61-17-25-81-27-28-82-26-24-75-35-45(70-71-75)34-72-20-22-73(23-21-72)46-13-14-51(62-32-46)68-52-30-48-49(33-63-52)67-58(66-44-11-9-43(60)10-12-44)69-55(48)74-18-15-41(37-77)16-19-74/h5-14,30,32-33,35,38,41,47,50,54,61,77-78H,15-29,31,34,36-37H2,1-4H3,(H,64,79)(H,62,63,68)(H,66,67,69)/t47-,50+,54-/m1/s1","SCALGKKEKZAYQL-PZUTWEFSSA-N"
"572","P00533","EGFR L858R/T790M","CRBN","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","979.108","978.438823436","6.07","72","8","14","4","20","234.34","C53H58N10O9","InChI=1S/C53H58N10O9/c1-4-43(64)55-34-15-13-16-36(30-34)62-47(68)29-33(2)38-32-54-53(59-49(38)62)57-39-22-21-35(31-42(39)72-3)60-25-27-61(28-26-60)46(67)20-12-10-8-6-5-7-9-11-19-44(65)56-40-18-14-17-37-48(40)52(71)63(51(37)70)41-23-24-45(66)58-50(41)69/h4,13-18,21-22,29-32,41H,1,5-12,19-20,23-28H2,2-3H3,(H,55,64)(H,56,65)(H,54,57,59)(H,58,66,69)","JYBLMIXCGVMISV-UHFFFAOYSA-N"
"572","P00533","EGFR","CRBN","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","979.108","978.438823436","6.07","72","8","14","4","20","234.34","C53H58N10O9","InChI=1S/C53H58N10O9/c1-4-43(64)55-34-15-13-16-36(30-34)62-47(68)29-33(2)38-32-54-53(59-49(38)62)57-39-22-21-35(31-42(39)72-3)60-25-27-61(28-26-60)46(67)20-12-10-8-6-5-7-9-11-19-44(65)56-40-18-14-17-37-48(40)52(71)63(51(37)70)41-23-24-45(66)58-50(41)69/h4,13-18,21-22,29-32,41H,1,5-12,19-20,23-28H2,2-3H3,(H,55,64)(H,56,65)(H,54,57,59)(H,58,66,69)","JYBLMIXCGVMISV-UHFFFAOYSA-N"
"573","P00533","EGFR L858R/T790M","cIAP1","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC6=CC=CC=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","999.271","998.574194708","7.71","73","6","13","6","27","226.14","C56H74N10O7","InChI=1S/C56H74N10O7/c1-6-49(67)60-41-22-19-23-43(35-41)66-51(69)33-39(4)44-37-59-56(63-53(44)66)62-46-26-25-42(36-48(46)73-5)64-28-30-65(31-29-64)50(68)24-17-12-10-8-7-9-11-13-18-27-58-54(71)47(32-38(2)3)61-55(72)52(70)45(57)34-40-20-15-14-16-21-40/h6,14-16,19-23,25-26,33,35-38,45,47,52,70H,1,7-13,17-18,24,27-32,34,57H2,2-5H3,(H,58,71)(H,60,67)(H,61,72)(H,59,62,63)/t45-,47+,52+/m1/s1","DOEISPNISSZUOZ-KTBSTWIUSA-N"
"573","P00533","EGFR","cIAP1","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC6=CC=CC=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","999.271","998.574194708","7.71","73","6","13","6","27","226.14","C56H74N10O7","InChI=1S/C56H74N10O7/c1-6-49(67)60-41-22-19-23-43(35-41)66-51(69)33-39(4)44-37-59-56(63-53(44)66)62-46-26-25-42(36-48(46)73-5)64-28-30-65(31-29-64)50(68)24-17-12-10-8-7-9-11-13-18-27-58-54(71)47(32-38(2)3)61-55(72)52(70)45(57)34-40-20-15-14-16-21-40/h6,14-16,19-23,25-26,33,35-38,45,47,52,70H,1,7-13,17-18,24,27-32,34,57H2,2-5H3,(H,58,71)(H,60,67)(H,61,72)(H,59,62,63)/t45-,47+,52+/m1/s1","DOEISPNISSZUOZ-KTBSTWIUSA-N"
"574","P00533","EGFR L858R/T790M","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1","263.8","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1307.385","1305.55090567","12.96","93","9","14","5","26","224.94","C71H79Cl2F2N11O7","InChI=1S/C71H79Cl2F2N11O7/c1-8-60(87)79-47-20-18-21-49(39-47)86-62(89)36-44(2)51-42-78-69(83-66(51)86)81-56-30-27-48(40-58(56)93-7)84-32-34-85(35-33-84)61(88)24-16-14-12-10-9-11-13-15-17-31-77-67(90)45-25-29-55(57(37-45)92-6)80-68(91)65-63(50-22-19-23-53(73)64(50)75)71(43-76,59(82-65)41-70(3,4)5)52-28-26-46(72)38-54(52)74/h8,18-23,25-30,36-40,42,59,63,65,82H,1,9-17,24,31-35,41H2,2-7H3,(H,77,90)(H,79,87)(H,80,91)(H,78,81,83)/t59-,63-,65+,71-/m0/s1","DCPNWQZQYCVVJX-UYDHSDFFSA-N"
"574","P00533","EGFR","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1307.385","1305.55090567","12.96","93","9","14","5","26","224.94","C71H79Cl2F2N11O7","InChI=1S/C71H79Cl2F2N11O7/c1-8-60(87)79-47-20-18-21-49(39-47)86-62(89)36-44(2)51-42-78-69(83-66(51)86)81-56-30-27-48(40-58(56)93-7)84-32-34-85(35-33-84)61(88)24-16-14-12-10-9-11-13-15-17-31-77-67(90)45-25-29-55(57(37-45)92-6)80-68(91)65-63(50-22-19-23-53(73)64(50)75)71(43-76,59(82-65)41-70(3,4)5)52-28-26-46(72)38-54(52)74/h8,18-23,25-30,36-40,42,59,63,65,82H,1,9-17,24,31-35,41H2,2-7H3,(H,77,90)(H,79,87)(H,80,91)(H,78,81,83)/t59-,63-,65+,71-/m0/s1","DCPNWQZQYCVVJX-UYDHSDFFSA-N"
"575","P00533","EGFR L858R/T790M","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1293.402","1291.57164111","13.92","92","9","14","5","27","207.87","C71H81Cl2F2N11O6","InChI=1S/C71H81Cl2F2N11O6/c1-8-61(87)79-48-21-19-22-50(40-48)86-62(88)37-45(2)52-43-78-69(83-66(52)86)81-57-30-27-49(41-59(57)92-7)85-35-33-84(34-36-85)32-18-16-14-12-10-9-11-13-15-17-31-77-67(89)46-25-29-56(58(38-46)91-6)80-68(90)65-63(51-23-20-24-54(73)64(51)75)71(44-76,60(82-65)42-70(3,4)5)53-28-26-47(72)39-55(53)74/h8,19-30,37-41,43,60,63,65,82H,1,9-18,31-36,42H2,2-7H3,(H,77,89)(H,79,87)(H,80,90)(H,78,81,83)/t60-,63-,65+,71-/m0/s1","UPZKEHBNYUDGOC-AFJHDGOUSA-N"
"575","P00533","EGFR","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1293.402","1291.57164111","13.92","92","9","14","5","27","207.87","C71H81Cl2F2N11O6","InChI=1S/C71H81Cl2F2N11O6/c1-8-61(87)79-48-21-19-22-50(40-48)86-62(88)37-45(2)52-43-78-69(83-66(52)86)81-57-30-27-49(41-59(57)92-7)85-35-33-84(34-36-85)32-18-16-14-12-10-9-11-13-15-17-31-77-67(89)46-25-29-56(58(38-46)91-6)80-68(90)65-63(51-23-20-24-54(73)64(51)75)71(44-76,60(82-65)42-70(3,4)5)53-28-26-47(72)39-55(53)74/h8,19-30,37-41,43,60,63,65,82H,1,9-18,31-36,42H2,2-7H3,(H,77,89)(H,79,87)(H,80,90)(H,78,81,83)/t60-,63-,65+,71-/m0/s1","UPZKEHBNYUDGOC-AFJHDGOUSA-N"
"576","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","312.9","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1136.434","1135.56772942","8.53","82","8","15","5","24","233.32","C62H77N11O8S","InChI=1S/C62H77N11O8S/c1-8-52(75)66-44-18-17-19-46(33-44)73-55(78)32-40(2)48-37-64-61(69-58(48)73)67-49-27-26-45(34-51(49)81-7)70-28-30-71(31-29-70)54(77)21-16-14-12-10-9-11-13-15-20-53(76)68-57(62(4,5)6)60(80)72-38-47(74)35-50(72)59(79)63-36-42-22-24-43(25-23-42)56-41(3)65-39-82-56/h8,17-19,22-27,32-34,37,39,47,50,57,74H,1,9-16,20-21,28-31,35-36,38H2,2-7H3,(H,63,79)(H,66,75)(H,68,76)(H,64,67,69)/t47-,50+,57-/m1/s1","GSUQPNOGNRJJQO-YTFMVYPUSA-N"
"576","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1136.434","1135.56772942","8.53","82","8","15","5","24","233.32","C62H77N11O8S","InChI=1S/C62H77N11O8S/c1-8-52(75)66-44-18-17-19-46(33-44)73-55(78)32-40(2)48-37-64-61(69-58(48)73)67-49-27-26-45(34-51(49)81-7)70-28-30-71(31-29-70)54(77)21-16-14-12-10-9-11-13-15-20-53(76)68-57(62(4,5)6)60(80)72-38-47(74)35-50(72)59(79)63-36-42-22-24-43(25-23-42)56-41(3)65-39-82-56/h8,17-19,22-27,32-34,37,39,47,50,57,74H,1,9-16,20-21,28-31,35-36,38H2,2-7H3,(H,63,79)(H,66,75)(H,68,76)(H,64,67,69)/t47-,50+,57-/m1/s1","GSUQPNOGNRJJQO-YTFMVYPUSA-N"
"577","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","25.3","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1122.451","1121.58846487","9.49","81","8","15","5","25","216.25","C62H79N11O7S","InChI=1S/C62H79N11O7S/c1-8-53(75)66-45-19-18-20-47(34-45)73-55(77)33-41(2)49-38-64-61(69-58(49)73)67-50-27-26-46(35-52(50)80-7)71-31-29-70(30-32-71)28-17-15-13-11-9-10-12-14-16-21-54(76)68-57(62(4,5)6)60(79)72-39-48(74)36-51(72)59(78)63-37-43-22-24-44(25-23-43)56-42(3)65-40-81-56/h8,18-20,22-27,33-35,38,40,48,51,57,74H,1,9-17,21,28-32,36-37,39H2,2-7H3,(H,63,78)(H,66,75)(H,68,76)(H,64,67,69)/t48-,51+,57-/m1/s1","HQGHIKHHXKBFOJ-OIQPADLRSA-N"
"577","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","50.3","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1122.451","1121.58846487","9.49","81","8","15","5","25","216.25","C62H79N11O7S","InChI=1S/C62H79N11O7S/c1-8-53(75)66-45-19-18-20-47(34-45)73-55(77)33-41(2)49-38-64-61(69-58(49)73)67-50-27-26-46(35-52(50)80-7)71-31-29-70(30-32-71)28-17-15-13-11-9-10-12-14-16-21-54(76)68-57(62(4,5)6)60(79)72-39-48(74)36-51(72)59(78)63-37-43-22-24-44(25-23-43)56-42(3)65-40-81-56/h8,18-20,22-27,33-35,38,40,48,51,57,74H,1,9-17,21,28-32,36-37,39H2,2-7H3,(H,63,78)(H,66,75)(H,68,76)(H,64,67,69)/t48-,51+,57-/m1/s1","HQGHIKHHXKBFOJ-OIQPADLRSA-N"
"578","P00533","EGFR L858R/T790M","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1","77","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1279.331","1277.51960554","11.88","91","9","14","5","24","224.94","C69H75Cl2F2N11O7","InChI=1S/C69H75Cl2F2N11O7/c1-8-58(85)77-45-18-16-19-47(37-45)84-60(87)34-42(2)49-40-76-67(81-64(49)84)79-54-28-25-46(38-56(54)91-7)82-30-32-83(33-31-82)59(86)22-14-12-10-9-11-13-15-29-75-65(88)43-23-27-53(55(35-43)90-6)78-66(89)63-61(48-20-17-21-51(71)62(48)73)69(41-74,57(80-63)39-68(3,4)5)50-26-24-44(70)36-52(50)72/h8,16-21,23-28,34-38,40,57,61,63,80H,1,9-15,22,29-33,39H2,2-7H3,(H,75,88)(H,77,85)(H,78,89)(H,76,79,81)/t57-,61-,63+,69-/m0/s1","GDBFIWQFEZVSAL-RBRUZKMXSA-N"
"578","P00533","EGFR","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1279.331","1277.51960554","11.88","91","9","14","5","24","224.94","C69H75Cl2F2N11O7","InChI=1S/C69H75Cl2F2N11O7/c1-8-58(85)77-45-18-16-19-47(37-45)84-60(87)34-42(2)49-40-76-67(81-64(49)84)79-54-28-25-46(38-56(54)91-7)82-30-32-83(33-31-82)59(86)22-14-12-10-9-11-13-15-29-75-65(88)43-23-27-53(55(35-43)90-6)78-66(89)63-61(48-20-17-21-51(71)62(48)73)69(41-74,57(80-63)39-68(3,4)5)50-26-24-44(70)36-52(50)72/h8,16-21,23-28,34-38,40,57,61,63,80H,1,9-15,22,29-33,39H2,2-7H3,(H,75,88)(H,77,85)(H,78,89)(H,76,79,81)/t57-,61-,63+,69-/m0/s1","GDBFIWQFEZVSAL-RBRUZKMXSA-N"
"579","P00533","EGFR L858R/T790M","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1251.277","1249.48830541","10.79","89","9","14","5","22","224.94","C67H71Cl2F2N11O7","InChI=1S/C67H71Cl2F2N11O7/c1-8-56(83)75-43-16-14-17-45(35-43)82-58(85)32-40(2)47-38-74-65(79-62(47)82)77-52-26-23-44(36-54(52)89-7)80-28-30-81(31-29-80)57(84)20-12-10-9-11-13-27-73-63(86)41-21-25-51(53(33-41)88-6)76-64(87)61-59(46-18-15-19-49(69)60(46)71)67(39-72,55(78-61)37-66(3,4)5)48-24-22-42(68)34-50(48)70/h8,14-19,21-26,32-36,38,55,59,61,78H,1,9-13,20,27-31,37H2,2-7H3,(H,73,86)(H,75,83)(H,76,87)(H,74,77,79)/t55-,59-,61+,67-/m0/s1","GGZIIUYEYTZDCD-ASJDMNHUSA-N"
"579","P00533","EGFR","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1251.277","1249.48830541","10.79","89","9","14","5","22","224.94","C67H71Cl2F2N11O7","InChI=1S/C67H71Cl2F2N11O7/c1-8-56(83)75-43-16-14-17-45(35-43)82-58(85)32-40(2)47-38-74-65(79-62(47)82)77-52-26-23-44(36-54(52)89-7)80-28-30-81(31-29-80)57(84)20-12-10-9-11-13-27-73-63(86)41-21-25-51(53(33-41)88-6)76-64(87)61-59(46-18-15-19-49(69)60(46)71)67(39-72,55(78-61)37-66(3,4)5)48-24-22-42(68)34-50(48)70/h8,14-19,21-26,32-36,38,55,59,61,78H,1,9-13,20,27-31,37H2,2-7H3,(H,73,86)(H,75,83)(H,76,87)(H,74,77,79)/t55-,59-,61+,67-/m0/s1","GGZIIUYEYTZDCD-ASJDMNHUSA-N"
"580","P00533","EGFR L858R/T790M","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1223.223","1221.45700528","9.71","87","9","14","5","20","224.94","C65H67Cl2F2N11O7","InChI=1S/C65H67Cl2F2N11O7/c1-8-54(81)73-41-14-12-15-43(33-41)80-56(83)30-38(2)45-36-72-63(77-60(45)80)75-50-24-21-42(34-52(50)87-7)78-26-28-79(29-27-78)55(82)18-10-9-11-25-71-61(84)39-19-23-49(51(31-39)86-6)74-62(85)59-57(44-16-13-17-47(67)58(44)69)65(37-70,53(76-59)35-64(3,4)5)46-22-20-40(66)32-48(46)68/h8,12-17,19-24,30-34,36,53,57,59,76H,1,9-11,18,25-29,35H2,2-7H3,(H,71,84)(H,73,81)(H,74,85)(H,72,75,77)/t53-,57-,59+,65-/m0/s1","KFRDCTCOKBRAAL-OIUJZHHCSA-N"
"580","P00533","EGFR","MDM2","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCNC(=O)C6=CC=C(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(C8=CC=C(Cl)C=C8F)[C@H]7C7=CC=CC(Cl)=C7F)C(OC)=C6)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1223.223","1221.45700528","9.71","87","9","14","5","20","224.94","C65H67Cl2F2N11O7","InChI=1S/C65H67Cl2F2N11O7/c1-8-54(81)73-41-14-12-15-43(33-41)80-56(83)30-38(2)45-36-72-63(77-60(45)80)75-50-24-21-42(34-52(50)87-7)78-26-28-79(29-27-78)55(82)18-10-9-11-25-71-61(84)39-19-23-49(51(31-39)86-6)74-62(85)59-57(44-16-13-17-47(67)58(44)69)65(37-70,53(76-59)35-64(3,4)5)46-22-20-40(66)32-48(46)68/h8,12-17,19-24,30-34,36,53,57,59,76H,1,9-11,18,25-29,35H2,2-7H3,(H,71,84)(H,73,81)(H,74,85)(H,72,75,77)/t53-,57-,59+,65-/m0/s1","KFRDCTCOKBRAAL-OIUJZHHCSA-N"
"581","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","69","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1108.38","1107.5364293","7.44","80","8","15","5","22","233.32","C60H73N11O8S","InChI=1S/C60H73N11O8S/c1-8-50(73)64-42-16-15-17-44(31-42)71-53(76)30-38(2)46-35-62-59(67-56(46)71)65-47-25-24-43(32-49(47)79-7)68-26-28-69(29-27-68)52(75)19-14-12-10-9-11-13-18-51(74)66-55(60(4,5)6)58(78)70-36-45(72)33-48(70)57(77)61-34-40-20-22-41(23-21-40)54-39(3)63-37-80-54/h8,15-17,20-25,30-32,35,37,45,48,55,72H,1,9-14,18-19,26-29,33-34,36H2,2-7H3,(H,61,77)(H,64,73)(H,66,74)(H,62,65,67)/t45-,48+,55-/m1/s1","NXHJICMMHCOKPI-ZRJZPVMUSA-N"
"581","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1108.38","1107.5364293","7.44","80","8","15","5","22","233.32","C60H73N11O8S","InChI=1S/C60H73N11O8S/c1-8-50(73)64-42-16-15-17-44(31-42)71-53(76)30-38(2)46-35-62-59(67-56(46)71)65-47-25-24-43(32-49(47)79-7)68-26-28-69(29-27-68)52(75)19-14-12-10-9-11-13-18-51(74)66-55(60(4,5)6)58(78)70-36-45(72)33-48(70)57(77)61-34-40-20-22-41(23-21-40)54-39(3)63-37-80-54/h8,15-17,20-25,30-32,35,37,45,48,55,72H,1,9-14,18-19,26-29,33-34,36H2,2-7H3,(H,61,77)(H,64,73)(H,66,74)(H,62,65,67)/t45-,48+,55-/m1/s1","NXHJICMMHCOKPI-ZRJZPVMUSA-N"
"582","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","235","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1080.326","1079.50512917","6.36","78","8","15","5","20","233.32","C58H69N11O8S","InChI=1S/C58H69N11O8S/c1-8-48(71)62-40-14-13-15-42(29-40)69-51(74)28-36(2)44-33-60-57(65-54(44)69)63-45-23-22-41(30-47(45)77-7)66-24-26-67(27-25-66)50(73)17-12-10-9-11-16-49(72)64-53(58(4,5)6)56(76)68-34-43(70)31-46(68)55(75)59-32-38-18-20-39(21-19-38)52-37(3)61-35-78-52/h8,13-15,18-23,28-30,33,35,43,46,53,70H,1,9-12,16-17,24-27,31-32,34H2,2-7H3,(H,59,75)(H,62,71)(H,64,72)(H,60,63,65)/t43-,46+,53-/m1/s1","HQDMTJMOYXRLMD-BSDSDUADSA-N"
"582","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1080.326","1079.50512917","6.36","78","8","15","5","20","233.32","C58H69N11O8S","InChI=1S/C58H69N11O8S/c1-8-48(71)62-40-14-13-15-42(29-40)69-51(74)28-36(2)44-33-60-57(65-54(44)69)63-45-23-22-41(30-47(45)77-7)66-24-26-67(27-25-66)50(73)17-12-10-9-11-16-49(72)64-53(58(4,5)6)56(76)68-34-43(70)31-46(68)55(75)59-32-38-18-20-39(21-19-38)52-37(3)61-35-78-52/h8,13-15,18-23,28-30,33,35,43,46,53,70H,1,9-12,16-17,24-27,31-32,34H2,2-7H3,(H,59,75)(H,62,71)(H,64,72)(H,60,63,65)/t43-,46+,53-/m1/s1","HQDMTJMOYXRLMD-BSDSDUADSA-N"
"583","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1052.272","1051.47382904","5.28","76","8","15","5","18","233.32","C56H65N11O8S","InChI=1S/C56H65N11O8S/c1-8-46(69)60-38-12-11-13-40(27-38)67-49(72)26-34(2)42-31-58-55(63-52(42)67)61-43-21-20-39(28-45(43)75-7)64-22-24-65(25-23-64)48(71)15-10-9-14-47(70)62-51(56(4,5)6)54(74)66-32-41(68)29-44(66)53(73)57-30-36-16-18-37(19-17-36)50-35(3)59-33-76-50/h8,11-13,16-21,26-28,31,33,41,44,51,68H,1,9-10,14-15,22-25,29-30,32H2,2-7H3,(H,57,73)(H,60,69)(H,62,70)(H,58,61,63)/t41-,44+,51-/m1/s1","SUWGYDIQBJOKHS-MSYDQUDQSA-N"
"583","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1052.272","1051.47382904","5.28","76","8","15","5","18","233.32","C56H65N11O8S","InChI=1S/C56H65N11O8S/c1-8-46(69)60-38-12-11-13-40(27-38)67-49(72)26-34(2)42-31-58-55(63-52(42)67)61-43-21-20-39(28-45(43)75-7)64-22-24-65(25-23-64)48(71)15-10-9-14-47(70)62-51(56(4,5)6)54(74)66-32-41(68)29-44(66)53(73)57-30-36-16-18-37(19-17-36)50-35(3)59-33-76-50/h8,11-13,16-21,26-28,31,33,41,44,51,68H,1,9-10,14-15,22-25,29-30,32H2,2-7H3,(H,57,73)(H,60,69)(H,62,70)(H,58,61,63)/t41-,44+,51-/m1/s1","SUWGYDIQBJOKHS-MSYDQUDQSA-N"
"584","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","132","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1094.397","1093.55716474","8.41","79","8","15","5","23","216.25","C60H75N11O7S","InChI=1S/C60H75N11O7S/c1-8-51(73)64-43-17-16-18-45(32-43)71-53(75)31-39(2)47-36-62-59(67-56(47)71)65-48-25-24-44(33-50(48)78-7)69-29-27-68(28-30-69)26-15-13-11-9-10-12-14-19-52(74)66-55(60(4,5)6)58(77)70-37-46(72)34-49(70)57(76)61-35-41-20-22-42(23-21-41)54-40(3)63-38-79-54/h8,16-18,20-25,31-33,36,38,46,49,55,72H,1,9-15,19,26-30,34-35,37H2,2-7H3,(H,61,76)(H,64,73)(H,66,74)(H,62,65,67)/t46-,49+,55-/m1/s1","WWVCWKWNVMYOAL-CKCQHBCRSA-N"
"584","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1094.397","1093.55716474","8.41","79","8","15","5","23","216.25","C60H75N11O7S","InChI=1S/C60H75N11O7S/c1-8-51(73)64-43-17-16-18-45(32-43)71-53(75)31-39(2)47-36-62-59(67-56(47)71)65-48-25-24-44(33-50(48)78-7)69-29-27-68(28-30-69)26-15-13-11-9-10-12-14-19-52(74)66-55(60(4,5)6)58(77)70-37-46(72)34-49(70)57(76)61-35-41-20-22-42(23-21-41)54-40(3)63-38-79-54/h8,16-18,20-25,31-33,36,38,46,49,55,72H,1,9-15,19,26-30,34-35,37H2,2-7H3,(H,61,76)(H,64,73)(H,66,74)(H,62,65,67)/t46-,49+,55-/m1/s1","WWVCWKWNVMYOAL-CKCQHBCRSA-N"
"585","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","466","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1066.343","1065.52586461","7.32","77","8","15","5","21","216.25","C58H71N11O7S","InChI=1S/C58H71N11O7S/c1-8-49(71)62-41-15-14-16-43(30-41)69-51(73)29-37(2)45-34-60-57(65-54(45)69)63-46-23-22-42(31-48(46)76-7)67-27-25-66(26-28-67)24-13-11-9-10-12-17-50(72)64-53(58(4,5)6)56(75)68-35-44(70)32-47(68)55(74)59-33-39-18-20-40(21-19-39)52-38(3)61-36-77-52/h8,14-16,18-23,29-31,34,36,44,47,53,70H,1,9-13,17,24-28,32-33,35H2,2-7H3,(H,59,74)(H,62,71)(H,64,72)(H,60,63,65)/t44-,47+,53-/m1/s1","UKICTJWYEJNYHR-JSYKSQSDSA-N"
"585","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1066.343","1065.52586461","7.32","77","8","15","5","21","216.25","C58H71N11O7S","InChI=1S/C58H71N11O7S/c1-8-49(71)62-41-15-14-16-43(30-41)69-51(73)29-37(2)45-34-60-57(65-54(45)69)63-46-23-22-42(31-48(46)76-7)67-27-25-66(26-28-67)24-13-11-9-10-12-17-50(72)64-53(58(4,5)6)56(75)68-35-44(70)32-47(68)55(74)59-33-39-18-20-40(21-19-39)52-38(3)61-36-77-52/h8,14-16,18-23,29-31,34,36,44,47,53,70H,1,9-13,17,24-28,32-33,35H2,2-7H3,(H,59,74)(H,62,71)(H,64,72)(H,60,63,65)/t44-,47+,53-/m1/s1","UKICTJWYEJNYHR-JSYKSQSDSA-N"
"586","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1","5.9","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","19.3","Inhibition of EGFR L858R/T790M by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","506","Inhibit proliferation of H1975 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1038.289","1037.49456448","6.24","75","8","15","5","19","216.25","C56H67N11O7S","InChI=1S/C56H67N11O7S/c1-8-47(69)60-39-13-12-14-41(28-39)67-49(71)27-35(2)43-32-58-55(63-52(43)67)61-44-21-20-40(29-46(44)74-7)65-25-23-64(24-26-65)22-11-9-10-15-48(70)62-51(56(4,5)6)54(73)66-33-42(68)30-45(66)53(72)57-31-37-16-18-38(19-17-37)50-36(3)59-34-75-50/h8,12-14,16-21,27-29,32,34,42,45,51,68H,1,9-11,15,22-26,30-31,33H2,2-7H3,(H,57,72)(H,60,69)(H,62,70)(H,58,61,63)/t42-,45+,51-/m1/s1","CBWIPIZLLNOTMZ-PDMHGPQCSA-N"
"586","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","",">1000","Inhibition of EGFR by ELISA","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","506","Inhibit proliferation of H1975 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1038.289","1037.49456448","6.24","75","8","15","5","19","216.25","C56H67N11O7S","InChI=1S/C56H67N11O7S/c1-8-47(69)60-39-13-12-14-41(28-39)67-49(71)27-35(2)43-32-58-55(63-52(43)67)61-44-21-20-40(29-46(44)74-7)65-25-23-64(24-26-65)22-11-9-10-15-48(70)62-51(56(4,5)6)54(73)66-33-42(68)30-45(66)53(72)57-31-37-16-18-38(19-17-37)50-36(3)59-34-75-50/h8,12-14,16-21,27-29,32,34,42,45,51,68H,1,9-11,15,22-26,30-31,33H2,2-7H3,(H,57,72)(H,60,69)(H,62,70)(H,58,61,63)/t42-,45+,51-/m1/s1","CBWIPIZLLNOTMZ-PDMHGPQCSA-N"
"587","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR L858R/T790M in H1975 cells after 16h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1010.235","1009.46326436","5.53","73","8","15","5","17","216.25","C54H63N11O7S","InChI=1S/C54H63N11O7S/c1-8-45(67)58-37-11-9-12-39(26-37)65-47(69)25-33(2)41-30-56-53(61-50(41)65)59-42-19-18-38(27-44(42)72-7)63-23-21-62(22-24-63)20-10-13-46(68)60-49(54(4,5)6)52(71)64-31-40(66)28-43(64)51(70)55-29-35-14-16-36(17-15-35)48-34(3)57-32-73-48/h8-9,11-12,14-19,25-27,30,32,40,43,49,66H,1,10,13,20-24,28-29,31H2,2-7H3,(H,55,70)(H,58,67)(H,60,68)(H,56,59,61)/t40-,43+,49-/m1/s1","GHHZCEDRWNWCTG-PCGSYBQZSA-N"
"587","P00533","EGFR","VHL","","","C=CC(=O)NC1=CC=CC(N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)=C1",">2000","","Degradation of EGFR in A431 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112199","1010.235","1009.46326436","5.53","73","8","15","5","17","216.25","C54H63N11O7S","InChI=1S/C54H63N11O7S/c1-8-45(67)58-37-11-9-12-39(26-37)65-47(69)25-33(2)41-30-56-53(61-50(41)65)59-42-19-18-38(27-44(42)72-7)63-23-21-62(22-24-63)20-10-13-46(68)60-49(54(4,5)6)52(71)64-31-40(66)28-43(64)51(70)55-29-35-14-16-36(17-15-35)48-34(3)57-32-73-48/h8-9,11-12,14-19,25-27,30,32,40,43,49,66H,1,10,13,20-24,28-29,31H2,2-7H3,(H,55,70)(H,58,67)(H,60,68)(H,56,59,61)/t40-,43+,49-/m1/s1","GHHZCEDRWNWCTG-PCGSYBQZSA-N"
"588","P00533","EGFR e19d","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1002.611","1001.40363681","5.56","70","7","14","4","20","200.68","C50H61ClFN9O8S","InChI=1S/C50H61ClFN9O8S/c1-31-45(70-30-56-31)33-9-7-32(8-10-33)27-53-48(65)40-24-35(62)28-61(40)49(66)46(50(2,3)4)58-43(63)13-21-68-22-14-44(64)60-18-16-59(17-19-60)15-6-20-69-42-25-36-39(26-41(42)67-5)54-29-55-47(36)57-34-11-12-38(52)37(51)23-34/h7-12,23,25-26,29-30,35,40,46,62H,6,13-22,24,27-28H2,1-5H3,(H,53,65)(H,58,63)(H,54,55,57)/t35-,40+,46-/m1/s1","HZVDJJAXDIAOHI-QRYWEXOJSA-N"
"588","P00533","EGFR L858R","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1002.611","1001.40363681","5.56","70","7","14","4","20","200.68","C50H61ClFN9O8S","InChI=1S/C50H61ClFN9O8S/c1-31-45(70-30-56-31)33-9-7-32(8-10-33)27-53-48(65)40-24-35(62)28-61(40)49(66)46(50(2,3)4)58-43(63)13-21-68-22-14-44(64)60-18-16-59(17-19-60)15-6-20-69-42-25-36-39(26-41(42)67-5)54-29-55-47(36)57-34-11-12-38(52)37(51)23-34/h7-12,23,25-26,29-30,35,40,46,62H,6,13-22,24,27-28H2,1-5H3,(H,53,65)(H,58,63)(H,54,55,57)/t35-,40+,46-/m1/s1","HZVDJJAXDIAOHI-QRYWEXOJSA-N"
"589","P00533","EGFR e19d","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1090.717","1089.45606631","5.26","76","7","16","4","26","219.14","C54H69ClFN9O10S","InChI=1S/C54H69ClFN9O10S/c1-35-49(76-34-60-35)37-9-7-36(8-10-37)31-57-52(69)44-28-39(66)32-65(44)53(70)50(54(2,3)4)62-47(67)13-21-72-23-25-74-26-24-73-22-14-48(68)64-18-16-63(17-19-64)15-6-20-75-46-29-40-43(30-45(46)71-5)58-33-59-51(40)61-38-11-12-42(56)41(55)27-38/h7-12,27,29-30,33-34,39,44,50,66H,6,13-26,28,31-32H2,1-5H3,(H,57,69)(H,62,67)(H,58,59,61)/t39-,44+,50-/m1/s1","DUHAIXHBBDGIBP-MLENZQCQSA-N"
"589","P00533","EGFR L858R","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1090.717","1089.45606631","5.26","76","7","16","4","26","219.14","C54H69ClFN9O10S","InChI=1S/C54H69ClFN9O10S/c1-35-49(76-34-60-35)37-9-7-36(8-10-37)31-57-52(69)44-28-39(66)32-65(44)53(70)50(54(2,3)4)62-47(67)13-21-72-23-25-74-26-24-73-22-14-48(68)64-18-16-63(17-19-64)15-6-20-75-46-29-40-43(30-45(46)71-5)58-33-59-51(40)61-38-11-12-42(56)41(55)27-38/h7-12,27,29-30,33-34,39,44,50,66H,6,13-26,28,31-32H2,1-5H3,(H,57,69)(H,62,67)(H,58,59,61)/t39-,44+,50-/m1/s1","DUHAIXHBBDGIBP-MLENZQCQSA-N"
"590","P00533","EGFR e19d","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1178.823","1177.5084958","4.97","82","7","18","4","32","237.6","C58H77ClFN9O12S","InChI=1S/C58H77ClFN9O12S/c1-39-53(82-38-64-39)41-9-7-40(8-10-41)35-61-56(73)48-32-43(70)36-69(48)57(74)54(58(2,3)4)66-51(71)13-21-76-23-25-78-27-29-80-30-28-79-26-24-77-22-14-52(72)68-18-16-67(17-19-68)15-6-20-81-50-33-44-47(34-49(50)75-5)62-37-63-55(44)65-42-11-12-46(60)45(59)31-42/h7-12,31,33-34,37-38,43,48,54,70H,6,13-30,32,35-36H2,1-5H3,(H,61,73)(H,66,71)(H,62,63,65)/t43-,48+,54-/m1/s1","PQNOXKXLYLTRFY-WBGXEMRLSA-N"
"590","P00533","EGFR L858R","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1178.823","1177.5084958","4.97","82","7","18","4","32","237.6","C58H77ClFN9O12S","InChI=1S/C58H77ClFN9O12S/c1-39-53(82-38-64-39)41-9-7-40(8-10-41)35-61-56(73)48-32-43(70)36-69(48)57(74)54(58(2,3)4)66-51(71)13-21-76-23-25-78-27-29-80-30-28-79-26-24-77-22-14-52(72)68-18-16-67(17-19-68)15-6-20-81-50-33-44-47(34-49(50)75-5)62-37-63-55(44)65-42-11-12-46(60)45(59)31-42/h7-12,31,33-34,37-38,43,48,54,70H,6,13-30,32,35-36H2,1-5H3,(H,61,73)(H,66,71)(H,62,63,65)/t43-,48+,54-/m1/s1","PQNOXKXLYLTRFY-WBGXEMRLSA-N"
"591","P00533","EGFR e19d","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","958.558","957.377422064","5.7","67","7","13","4","17","191.45","C48H57ClFN9O7S","InChI=1S/C48H57ClFN9O7S/c1-29-43(67-28-54-29)31-9-7-30(8-10-31)25-51-46(63)38-22-33(60)26-59(38)47(64)44(48(2,3)4)56-41(61)13-14-42(62)58-18-16-57(17-19-58)15-6-20-66-40-23-34-37(24-39(40)65-5)52-27-53-45(34)55-32-11-12-36(50)35(49)21-32/h7-12,21,23-24,27-28,33,38,44,60H,6,13-20,22,25-26H2,1-5H3,(H,51,63)(H,56,61)(H,52,53,55)/t33-,38+,44-/m1/s1","DUGBSNFGNATMEE-VSPJSQPSSA-N"
"591","P00533","EGFR L858R","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","958.558","957.377422064","5.7","67","7","13","4","17","191.45","C48H57ClFN9O7S","InChI=1S/C48H57ClFN9O7S/c1-29-43(67-28-54-29)31-9-7-30(8-10-31)25-51-46(63)38-22-33(60)26-59(38)47(64)44(48(2,3)4)56-41(61)13-14-42(62)58-18-16-57(17-19-58)15-6-20-66-40-23-34-37(24-39(40)65-5)52-27-53-45(34)55-32-11-12-36(50)35(49)21-32/h7-12,21,23-24,27-28,33,38,44,60H,6,13-20,22,25-26H2,1-5H3,(H,51,63)(H,56,61)(H,52,53,55)/t33-,38+,44-/m1/s1","DUGBSNFGNATMEE-VSPJSQPSSA-N"
"592","P00533","EGFR e19d","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1000.639","999.424372256","6.96","70","7","13","4","20","191.45","C51H63ClFN9O7S","InChI=1S/C51H63ClFN9O7S/c1-32-46(70-31-57-32)34-14-12-33(13-15-34)28-54-49(66)41-25-36(63)29-62(41)50(67)47(51(2,3)4)59-44(64)10-7-6-8-11-45(65)61-21-19-60(20-22-61)18-9-23-69-43-26-37-40(27-42(43)68-5)55-30-56-48(37)58-35-16-17-39(53)38(52)24-35/h12-17,24,26-27,30-31,36,41,47,63H,6-11,18-23,25,28-29H2,1-5H3,(H,54,66)(H,59,64)(H,55,56,58)/t36-,41+,47-/m1/s1","ISBWTTKCXBFWJM-FGUOTCRGSA-N"
"592","P00533","EGFR L858R","VHL","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1000.639","999.424372256","6.96","70","7","13","4","20","191.45","C51H63ClFN9O7S","InChI=1S/C51H63ClFN9O7S/c1-32-46(70-31-57-32)34-14-12-33(13-15-34)28-54-49(66)41-25-36(63)29-62(41)50(67)47(51(2,3)4)59-44(64)10-7-6-8-11-45(65)61-21-19-60(20-22-61)18-9-23-69-43-26-37-40(27-42(43)68-5)55-30-56-48(37)58-35-16-17-39(53)38(52)24-35/h12-17,24,26-27,30-31,36,41,47,63H,6-11,18-23,25,28-29H2,1-5H3,(H,54,66)(H,59,64)(H,55,56,58)/t36-,41+,47-/m1/s1","ISBWTTKCXBFWJM-FGUOTCRGSA-N"
"593","P00533","EGFR L858R","VHL","","MS39","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","3.3","","Degradation of EGFR L858R in H3255 cells after 16 h treatment","","","","","","","12","Kd of EGFR L858R was assessed by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1056.747","1055.48697251","9.13","74","7","13","4","24","191.45","C55H71ClFN9O7S","InChI=1S/C55H71ClFN9O7S/c1-36-50(74-35-61-36)38-18-16-37(17-19-38)32-58-53(70)45-29-40(67)33-66(45)54(71)51(55(2,3)4)63-48(68)14-11-9-7-6-8-10-12-15-49(69)65-25-23-64(24-26-65)22-13-27-73-47-30-41-44(31-46(47)72-5)59-34-60-52(41)62-39-20-21-43(57)42(56)28-39/h16-21,28,30-31,34-35,40,45,51,67H,6-15,22-27,29,32-33H2,1-5H3,(H,58,70)(H,63,68)(H,59,60,62)/t40-,45+,51-/m1/s1","HLFLODKZIGYHNR-LTEFSYCBSA-N"
"593","P00533","EGFR e19d","VHL","","MS39","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(C(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","5","","Degradation of EGFR e19d in HCC-827 cells after 16 h treatment","","","","","","","11","Kd of EGFR WT was assessed by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1056.747","1055.48697251","9.13","74","7","13","4","24","191.45","C55H71ClFN9O7S","InChI=1S/C55H71ClFN9O7S/c1-36-50(74-35-61-36)38-18-16-37(17-19-38)32-58-53(70)45-29-40(67)33-66(45)54(71)51(55(2,3)4)63-48(68)14-11-9-7-6-8-10-12-15-49(69)65-25-23-64(24-26-65)22-13-27-73-47-30-41-44(31-46(47)72-5)59-34-60-52(41)62-39-20-21-43(57)42(56)28-39/h16-21,28,30-31,34-35,40,45,51,67H,6-15,22-27,29,32-33H2,1-5H3,(H,58,70)(H,63,68)(H,59,60,62)/t40-,45+,51-/m1/s1","HLFLODKZIGYHNR-LTEFSYCBSA-N"
"594","P00533","EGFR e19d","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","860.344","859.322015364","3.83","61","7","14","4","19","196.66","C42H47ClFN9O8","InChI=1S/C42H47ClFN9O8/c1-59-34-24-32-28(39(48-25-47-32)49-26-6-7-30(44)29(43)22-26)23-35(34)61-19-3-13-51-15-17-52(18-16-51)14-10-36(54)46-12-21-60-20-11-45-31-5-2-4-27-38(31)42(58)53(41(27)57)33-8-9-37(55)50-40(33)56/h2,4-7,22-25,33,45H,3,8-21H2,1H3,(H,46,54)(H,47,48,49)(H,50,55,56)","PDCRYPGMVLBRTP-UHFFFAOYSA-N"
"594","P00533","EGFR L858R","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","860.344","859.322015364","3.83","61","7","14","4","19","196.66","C42H47ClFN9O8","InChI=1S/C42H47ClFN9O8/c1-59-34-24-32-28(39(48-25-47-32)49-26-6-7-30(44)29(43)22-26)23-35(34)61-19-3-13-51-15-17-52(18-16-51)14-10-36(54)46-12-21-60-20-11-45-31-5-2-4-27-38(31)42(58)53(41(27)57)33-8-9-37(55)50-40(33)56/h2,4-7,22-25,33,45H,3,8-21H2,1H3,(H,46,54)(H,47,48,49)(H,50,55,56)","PDCRYPGMVLBRTP-UHFFFAOYSA-N"
"595","P00533","EGFR e19d","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCOCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1036.556","1035.42687436","3.24","73","7","18","4","31","233.58","C50H63ClFN9O12","InChI=1S/C50H63ClFN9O12/c1-67-42-32-40-36(47(56-33-55-40)57-34-6-7-38(52)37(51)30-34)31-43(42)73-19-3-13-59-15-17-60(18-16-59)14-10-44(62)54-12-21-69-23-25-71-27-29-72-28-26-70-24-22-68-20-11-53-39-5-2-4-35-46(39)50(66)61(49(35)65)41-8-9-45(63)58-48(41)64/h2,4-7,30-33,41,53H,3,8-29H2,1H3,(H,54,62)(H,55,56,57)(H,58,63,64)","NKTVFYFQSABEHM-UHFFFAOYSA-N"
"595","P00533","EGFR L858R","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCOCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","1036.556","1035.42687436","3.24","73","7","18","4","31","233.58","C50H63ClFN9O12","InChI=1S/C50H63ClFN9O12/c1-67-42-32-40-36(47(56-33-55-40)57-34-6-7-38(52)37(51)30-34)31-43(42)73-19-3-13-59-15-17-60(18-16-59)14-10-44(62)54-12-21-69-23-25-71-27-29-72-28-26-70-24-22-68-20-11-53-39-5-2-4-35-46(39)50(66)61(49(35)65)41-8-9-45(63)58-48(41)64/h2,4-7,30-33,41,53H,3,8-29H2,1H3,(H,54,62)(H,55,56,57)(H,58,63,64)","NKTVFYFQSABEHM-UHFFFAOYSA-N"
"596","P00533","EGFR e19d","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","872.399","871.358400872","5.4","62","7","13","4","20","187.43","C44H51ClFN9O7","InChI=1S/C44H51ClFN9O7/c1-61-36-26-34-30(41(50-27-49-34)51-28-10-11-32(46)31(45)24-28)25-37(36)62-23-7-17-53-19-21-54(22-20-53)18-14-38(56)48-16-5-3-2-4-15-47-33-9-6-8-29-40(33)44(60)55(43(29)59)35-12-13-39(57)52-42(35)58/h6,8-11,24-27,35,47H,2-5,7,12-23H2,1H3,(H,48,56)(H,49,50,51)(H,52,57,58)","MPXZGDAUSAQINZ-UHFFFAOYSA-N"
"596","P00533","EGFR L858R","CRBN","","","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","872.399","871.358400872","5.4","62","7","13","4","20","187.43","C44H51ClFN9O7","InChI=1S/C44H51ClFN9O7/c1-61-36-26-34-30(41(50-27-49-34)51-28-10-11-32(46)31(45)24-28)25-37(36)62-23-7-17-53-19-21-54(22-20-53)18-14-38(56)48-16-5-3-2-4-15-47-33-9-6-8-29-40(33)44(60)55(43(29)59)35-12-13-39(57)52-42(35)58/h6,8-11,24-27,35,47H,2-5,7,12-23H2,1H3,(H,48,56)(H,49,50,51)(H,52,57,58)","MPXZGDAUSAQINZ-UHFFFAOYSA-N"
"597","P00533","EGFR L858R","CRBN","","MS154","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCCCCCCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","25","","Degradation of EGFR L858R in H3255 cells after 16 h treatment","","","","","","","3.8","Kd of EGFR L858R was assessed by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","901.437","900.373716588","5.92","64","7","13","3","22","184.63","C46H54ClFN8O8","InChI=1S/C46H54ClFN8O8/c1-62-38-28-35-32(43(51-29-50-35)52-30-12-13-34(48)33(47)26-30)27-39(38)64-25-9-18-54-20-22-55(23-21-54)19-16-40(57)49-17-6-4-2-3-5-7-24-63-37-11-8-10-31-42(37)46(61)56(45(31)60)36-14-15-41(58)53-44(36)59/h8,10-13,26-29,36H,2-7,9,14-25H2,1H3,(H,49,57)(H,50,51,52)(H,53,58,59)","ALKKWBPMCDDKKA-UHFFFAOYSA-N"
"597","P00533","EGFR e19d","CRBN","","MS154","COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN1CCN(CCC(=O)NCCCCCCCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","11","","Degradation of EGFR e19d in HCC-827 cells after 16 h treatment","","","","","","","1.8","Kd of EGFR WT was assessed by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01566","901.437","900.373716588","5.92","64","7","13","3","22","184.63","C46H54ClFN8O8","InChI=1S/C46H54ClFN8O8/c1-62-38-28-35-32(43(51-29-50-35)52-30-12-13-34(48)33(47)26-30)27-39(38)64-25-9-18-54-20-22-55(23-21-54)19-16-40(57)49-17-6-4-2-3-5-7-24-63-37-11-8-10-31-42(37)46(61)56(45(31)60)36-14-15-41(58)53-44(36)59/h8,10-13,26-29,36H,2-7,9,14-25H2,1H3,(H,49,57)(H,50,51,52)(H,53,58,59)","ALKKWBPMCDDKKA-UHFFFAOYSA-N"
"598","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","781.61","780.182580028","2.03","54","6","10","5","12","229.07","C35H34Cl2N8O9","InChI=1S/C35H34Cl2N8O9/c36-20-5-2-6-21(37)29(20)32(50)41-22-16-39-43-30(22)33(51)40-18-11-14-44(15-12-18)27(48)8-3-13-38-26(47)17-54-24-7-1-4-19-28(24)35(53)45(34(19)52)23-9-10-25(46)42-31(23)49/h1-2,4-7,16,18,23H,3,8-15,17H2,(H,38,47)(H,39,43)(H,40,51)(H,41,50)(H,42,46,49)","QYQCPQCOTGJFJH-UHFFFAOYSA-N"
"598","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","781.61","780.182580028","2.03","54","6","10","5","12","229.07","C35H34Cl2N8O9","InChI=1S/C35H34Cl2N8O9/c36-20-5-2-6-21(37)29(20)32(50)41-22-16-39-43-30(22)33(51)40-18-11-14-44(15-12-18)27(48)8-3-13-38-26(47)17-54-24-7-1-4-19-28(24)35(53)45(34(19)52)23-9-10-25(46)42-31(23)49/h1-2,4-7,16,18,23H,3,8-15,17H2,(H,38,47)(H,39,43)(H,40,51)(H,41,50)(H,42,46,49)","QYQCPQCOTGJFJH-UHFFFAOYSA-N"
"599","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","809.664","808.213880156","2.74","56","6","10","5","14","229.07","C37H38Cl2N8O9","InChI=1S/C37H38Cl2N8O9/c38-22-7-5-8-23(39)31(22)34(52)43-24-18-41-45-32(24)35(53)42-20-13-16-46(17-14-20)29(50)10-2-1-3-15-40-28(49)19-56-26-9-4-6-21-30(26)37(55)47(36(21)54)25-11-12-27(48)44-33(25)51/h4-9,18,20,25H,1-3,10-17,19H2,(H,40,49)(H,41,45)(H,42,53)(H,43,52)(H,44,48,51)","SDKFCLVFMQKIGR-UHFFFAOYSA-N"
"599","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","809.664","808.213880156","2.74","56","6","10","5","14","229.07","C37H38Cl2N8O9","InChI=1S/C37H38Cl2N8O9/c38-22-7-5-8-23(39)31(22)34(52)43-24-18-41-45-32(24)35(53)42-20-13-16-46(17-14-20)29(50)10-2-1-3-15-40-28(49)19-56-26-9-4-6-21-30(26)37(55)47(36(21)54)25-11-12-27(48)44-33(25)51/h4-9,18,20,25H,1-3,10-17,19H2,(H,40,49)(H,41,45)(H,42,53)(H,43,52)(H,44,48,51)","SDKFCLVFMQKIGR-UHFFFAOYSA-N"
"600","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5950","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","780.626","779.19856444","2.14","54","6","10","6","12","231.87","C35H35Cl2N9O8","InChI=1S/C35H35Cl2N9O8/c36-20-4-2-5-21(37)29(20)32(51)42-23-17-40-44-30(23)33(52)41-18-11-15-45(16-12-18)27(49)10-9-25(47)39-14-13-38-22-6-1-3-19-28(22)35(54)46(34(19)53)24-7-8-26(48)43-31(24)50/h1-6,17-18,24,38H,7-16H2,(H,39,47)(H,40,44)(H,41,52)(H,42,51)(H,43,48,50)","SFNVMXISDYVTJK-UHFFFAOYSA-N"
"600","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5950","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","780.626","779.19856444","2.14","54","6","10","6","12","231.87","C35H35Cl2N9O8","InChI=1S/C35H35Cl2N9O8/c36-20-4-2-5-21(37)29(20)32(51)42-23-17-40-44-30(23)33(52)41-18-11-15-45(16-12-18)27(49)10-9-25(47)39-14-13-38-22-6-1-3-19-28(22)35(54)46(34(19)53)24-7-8-26(48)43-31(24)50/h1-6,17-18,24,38H,7-16H2,(H,39,47)(H,40,44)(H,41,52)(H,42,51)(H,43,48,50)","SFNVMXISDYVTJK-UHFFFAOYSA-N"
"601","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","23320","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","808.68","807.229864568","2.85","56","6","10","6","14","231.87","C37H39Cl2N9O8","InChI=1S/C37H39Cl2N9O8/c38-22-6-4-7-23(39)31(22)34(53)44-25-19-42-46-32(25)35(54)43-20-13-17-47(18-14-20)29(51)12-11-27(49)41-16-2-1-15-40-24-8-3-5-21-30(24)37(56)48(36(21)55)26-9-10-28(50)45-33(26)52/h3-8,19-20,26,40H,1-2,9-18H2,(H,41,49)(H,42,46)(H,43,54)(H,44,53)(H,45,50,52)","LCRUIXHKZDGQEU-UHFFFAOYSA-N"
"601","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","23320","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","808.68","807.229864568","2.85","56","6","10","6","14","231.87","C37H39Cl2N9O8","InChI=1S/C37H39Cl2N9O8/c38-22-6-4-7-23(39)31(22)34(53)44-25-19-42-46-32(25)35(54)43-20-13-17-47(18-14-20)29(51)12-11-27(49)41-16-2-1-15-40-24-8-3-5-21-30(24)37(56)48(36(21)55)26-9-10-28(50)45-33(26)52/h3-8,19-20,26,40H,1-2,9-18H2,(H,41,49)(H,42,46)(H,43,54)(H,44,53)(H,45,50,52)","LCRUIXHKZDGQEU-UHFFFAOYSA-N"
"602","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14560","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","836.734","835.261164696","3.57","58","6","10","6","16","231.87","C39H43Cl2N9O8","InChI=1S/C39H43Cl2N9O8/c40-24-8-6-9-25(41)33(24)36(55)46-27-21-44-48-34(27)37(56)45-22-15-19-49(20-16-22)31(53)14-13-29(51)43-18-4-2-1-3-17-42-26-10-5-7-23-32(26)39(58)50(38(23)57)28-11-12-30(52)47-35(28)54/h5-10,21-22,28,42H,1-4,11-20H2,(H,43,51)(H,44,48)(H,45,56)(H,46,55)(H,47,52,54)","DQXIAQMKNGYGDW-UHFFFAOYSA-N"
"602","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14560","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","836.734","835.261164696","3.57","58","6","10","6","16","231.87","C39H43Cl2N9O8","InChI=1S/C39H43Cl2N9O8/c40-24-8-6-9-25(41)33(24)36(55)46-27-21-44-48-34(27)37(56)45-22-15-19-49(20-16-22)31(53)14-13-29(51)43-18-4-2-1-3-17-42-26-10-5-7-23-32(26)39(58)50(38(23)57)28-11-12-30(52)47-35(28)54/h5-10,21-22,28,42H,1-4,11-20H2,(H,43,51)(H,44,48)(H,45,56)(H,46,55)(H,47,52,54)","DQXIAQMKNGYGDW-UHFFFAOYSA-N"
"603","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","838.662","837.204043744","0.92","58","6","11","6","14","258.17","C37H37Cl2N9O10","InChI=1S/C37H37Cl2N9O10/c38-21-4-2-5-22(39)31(21)34(54)44-23-17-42-46-32(23)35(55)43-19-11-15-47(16-12-19)29(52)10-9-26(49)40-13-14-41-28(51)18-58-25-6-1-3-20-30(25)37(57)48(36(20)56)24-7-8-27(50)45-33(24)53/h1-6,17,19,24H,7-16,18H2,(H,40,49)(H,41,51)(H,42,46)(H,43,55)(H,44,54)(H,45,50,53)","CCBJHEFTSORGTK-UHFFFAOYSA-N"
"603","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","838.662","837.204043744","0.92","58","6","11","6","14","258.17","C37H37Cl2N9O10","InChI=1S/C37H37Cl2N9O10/c38-21-4-2-5-22(39)31(21)34(54)44-23-17-42-46-32(23)35(55)43-19-11-15-47(16-12-19)29(52)10-9-26(49)40-13-14-41-28(51)18-58-25-6-1-3-20-30(25)37(57)48(36(20)56)24-7-8-27(50)45-33(24)53/h1-6,17,19,24H,7-16,18H2,(H,40,49)(H,41,51)(H,42,46)(H,43,55)(H,44,54)(H,45,50,53)","CCBJHEFTSORGTK-UHFFFAOYSA-N"
"604","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","866.716","865.235343872","1.63","60","6","11","6","16","258.17","C39H41Cl2N9O10","InChI=1S/C39H41Cl2N9O10/c40-23-6-4-7-24(41)33(23)36(56)46-25-19-44-48-34(25)37(57)45-21-13-17-49(18-14-21)31(54)12-11-28(51)42-15-1-2-16-43-30(53)20-60-27-8-3-5-22-32(27)39(59)50(38(22)58)26-9-10-29(52)47-35(26)55/h3-8,19,21,26H,1-2,9-18,20H2,(H,42,51)(H,43,53)(H,44,48)(H,45,57)(H,46,56)(H,47,52,55)","YFJRYUARJIDLMN-UHFFFAOYSA-N"
"604","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","866.716","865.235343872","1.63","60","6","11","6","16","258.17","C39H41Cl2N9O10","InChI=1S/C39H41Cl2N9O10/c40-23-6-4-7-24(41)33(23)36(56)46-25-19-44-48-34(25)37(57)45-21-13-17-49(18-14-21)31(54)12-11-28(51)42-15-1-2-16-43-30(53)20-60-27-8-3-5-22-32(27)39(59)50(38(22)58)26-9-10-29(52)47-35(26)55/h3-8,19,21,26H,1-2,9-18,20H2,(H,42,51)(H,43,53)(H,44,48)(H,45,57)(H,46,56)(H,47,52,55)","YFJRYUARJIDLMN-UHFFFAOYSA-N"
"605","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1310","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","894.77","893.266644","2.35","62","6","11","6","18","258.17","C41H45Cl2N9O10","InChI=1S/C41H45Cl2N9O10/c42-25-8-6-9-26(43)35(25)38(58)48-27-21-46-50-36(27)39(59)47-23-15-19-51(20-16-23)33(56)14-13-30(53)44-17-3-1-2-4-18-45-32(55)22-62-29-10-5-7-24-34(29)41(61)52(40(24)60)28-11-12-31(54)49-37(28)57/h5-10,21,23,28H,1-4,11-20,22H2,(H,44,53)(H,45,55)(H,46,50)(H,47,59)(H,48,58)(H,49,54,57)","CLSOISUBUKOHQI-UHFFFAOYSA-N"
"605","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1310","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","894.77","893.266644","2.35","62","6","11","6","18","258.17","C41H45Cl2N9O10","InChI=1S/C41H45Cl2N9O10/c42-25-8-6-9-26(43)35(25)38(58)48-27-21-46-50-36(27)39(59)47-23-15-19-51(20-16-23)33(56)14-13-30(53)44-17-3-1-2-4-18-45-32(55)22-62-29-10-5-7-24-34(29)41(61)52(40(24)60)28-11-12-31(54)49-37(28)57/h5-10,21,23,28H,1-4,11-20,22H2,(H,44,53)(H,45,55)(H,46,50)(H,47,59)(H,48,58)(H,49,54,57)","CLSOISUBUKOHQI-UHFFFAOYSA-N"
"606","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","840","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","841.662","840.203709396","1.47","58","6","12","5","16","247.53","C37H38Cl2N8O11","InChI=1S/C37H38Cl2N8O11/c38-22-4-2-5-23(39)31(22)34(52)43-24-17-41-45-32(24)35(53)42-20-9-12-46(13-10-20)29(50)19-57-16-15-56-14-11-40-28(49)18-58-26-6-1-3-21-30(26)37(55)47(36(21)54)25-7-8-27(48)44-33(25)51/h1-6,17,20,25H,7-16,18-19H2,(H,40,49)(H,41,45)(H,42,53)(H,43,52)(H,44,48,51)","KTLSDRIBLSMWHN-UHFFFAOYSA-N"
"606","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","840","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","841.662","840.203709396","1.47","58","6","12","5","16","247.53","C37H38Cl2N8O11","InChI=1S/C37H38Cl2N8O11/c38-22-4-2-5-23(39)31(22)34(52)43-24-17-41-45-32(24)35(53)42-20-9-12-46(13-10-20)29(50)19-57-16-15-56-14-11-40-28(49)18-58-26-6-1-3-21-30(26)37(55)47(36(21)54)25-7-8-27(48)44-33(25)51/h1-6,17,20,25H,7-16,18-19H2,(H,40,49)(H,41,45)(H,42,53)(H,43,52)(H,44,48,51)","KTLSDRIBLSMWHN-UHFFFAOYSA-N"
"607","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2020","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","998.875","997.313988116","1.19","69","6","14","6","25","285.86","C45H53Cl2N9O13","InChI=1S/C45H53Cl2N9O13/c46-29-6-2-7-30(47)39(29)42(62)52-31-25-50-54-40(31)43(63)51-27-13-17-55(18-14-27)37(60)12-11-34(57)48-15-3-19-66-21-23-68-24-22-67-20-4-16-49-36(59)26-69-33-8-1-5-28-38(33)45(65)56(44(28)64)32-9-10-35(58)53-41(32)61/h1-2,5-8,25,27,32H,3-4,9-24,26H2,(H,48,57)(H,49,59)(H,50,54)(H,51,63)(H,52,62)(H,53,58,61)","BMDDGQMQYPWSHA-UHFFFAOYSA-N"
"607","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCC(NC(=O)C2=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=N[NH]2)CC1)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2020","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","998.875","997.313988116","1.19","69","6","14","6","25","285.86","C45H53Cl2N9O13","InChI=1S/C45H53Cl2N9O13/c46-29-6-2-7-30(47)39(29)42(62)52-31-25-50-54-40(31)43(63)51-27-13-17-55(18-14-27)37(60)12-11-34(57)48-15-3-19-66-21-23-68-24-22-67-20-4-16-49-36(59)26-69-33-8-1-5-28-38(33)45(65)56(44(28)64)32-9-10-35(58)53-41(32)61/h1-2,5-8,25,27,32H,3-4,9-24,26H2,(H,48,57)(H,49,59)(H,50,54)(H,51,63)(H,52,62)(H,53,58,61)","BMDDGQMQYPWSHA-UHFFFAOYSA-N"
"608","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2210","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","816.836","816.30920624","1.17","60","8","13","6","14","256.81","C40H40N12O8","InChI=1S/C40H40N12O8/c53-30-11-10-28(37(56)48-30)52-39(58)25-3-1-4-29(33(25)40(52)59)60-21-31(54)41-13-2-5-32(55)51-17-15-50(16-18-51)20-23-6-8-24(9-7-23)46-38(57)34-27(19-45-49-34)47-36-26-12-14-42-35(26)43-22-44-36/h1,3-4,6-9,12,14,19,22,28H,2,5,10-11,13,15-18,20-21H2,(H,41,54)(H,45,49)(H,46,57)(H,48,53,56)(H2,42,43,44,47)","BXNIESGZFOBFBH-UHFFFAOYSA-N"
"608","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2210","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","816.836","816.30920624","1.17","60","8","13","6","14","256.81","C40H40N12O8","InChI=1S/C40H40N12O8/c53-30-11-10-28(37(56)48-30)52-39(58)25-3-1-4-29(33(25)40(52)59)60-21-31(54)41-13-2-5-32(55)51-17-15-50(16-18-51)20-23-6-8-24(9-7-23)46-38(57)34-27(19-45-49-34)47-36-26-12-14-42-35(26)43-22-44-36/h1,3-4,6-9,12,14,19,22,28H,2,5,10-11,13,15-18,20-21H2,(H,41,54)(H,45,49)(H,46,57)(H,48,53,56)(H2,42,43,44,47)","BXNIESGZFOBFBH-UHFFFAOYSA-N"
"609","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","540","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","844.89","844.340506368","1.88","62","8","13","6","16","256.81","C42H44N12O8","InChI=1S/C42H44N12O8/c55-32-13-12-30(39(58)50-32)54-41(60)27-5-4-6-31(35(27)42(54)61)62-23-33(56)43-15-3-1-2-7-34(57)53-19-17-52(18-20-53)22-25-8-10-26(11-9-25)48-40(59)36-29(21-47-51-36)49-38-28-14-16-44-37(28)45-24-46-38/h4-6,8-11,14,16,21,24,30H,1-3,7,12-13,15,17-20,22-23H2,(H,43,56)(H,47,51)(H,48,59)(H,50,55,58)(H2,44,45,46,49)","DREFRNAJSLXOLV-UHFFFAOYSA-N"
"609","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","540","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","844.89","844.340506368","1.88","62","8","13","6","16","256.81","C42H44N12O8","InChI=1S/C42H44N12O8/c55-32-13-12-30(39(58)50-32)54-41(60)27-5-4-6-31(35(27)42(54)61)62-23-33(56)43-15-3-1-2-7-34(57)53-19-17-52(18-20-53)22-25-8-10-26(11-9-25)48-40(59)36-29(21-47-51-36)49-38-28-14-16-44-37(28)45-24-46-38/h4-6,8-11,14,16,21,24,30H,1-3,7,12-13,15,17-20,22-23H2,(H,43,56)(H,47,51)(H,48,59)(H,50,55,58)(H2,44,45,46,49)","DREFRNAJSLXOLV-UHFFFAOYSA-N"
"610","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","62","","Degradation of CDK2 in PC-3 cells after 24 h treatment","","","7.42","Inhibition of CDK2/cyclin A","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","120","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","815.852","815.325190652","1.28","60","8","13","7","14","259.61","C40H41N13O7","InChI=1S/C40H41N13O7/c54-30(42-15-14-41-27-3-1-2-25-33(27)40(60)53(39(25)59)29-8-9-31(55)49-37(29)57)10-11-32(56)52-18-16-51(17-19-52)21-23-4-6-24(7-5-23)47-38(58)34-28(20-46-50-34)48-36-26-12-13-43-35(26)44-22-45-36/h1-7,12-13,20,22,29,41H,8-11,14-19,21H2,(H,42,54)(H,46,50)(H,47,58)(H,49,55,57)(H2,43,44,45,48)","BRYMZSSAIDEFEM-UHFFFAOYSA-N"
"610","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","33","","Degradation of CDK9 in PC-3 cells after 24 h treatment","","","14.5","Inhibition of CDK9/cyclin T1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","120","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","815.852","815.325190652","1.28","60","8","13","7","14","259.61","C40H41N13O7","InChI=1S/C40H41N13O7/c54-30(42-15-14-41-27-3-1-2-25-33(27)40(60)53(39(25)59)29-8-9-31(55)49-37(29)57)10-11-32(56)52-18-16-51(17-19-52)21-23-4-6-24(7-5-23)47-38(58)34-28(20-46-50-34)48-36-26-12-13-43-35(26)44-22-45-36/h1-7,12-13,20,22,29,41H,8-11,14-19,21H2,(H,42,54)(H,46,50)(H,47,58)(H,49,55,57)(H2,43,44,45,48)","BRYMZSSAIDEFEM-UHFFFAOYSA-N"
"611","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1380","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","843.906","843.35649078","1.99","62","8","13","7","16","259.61","C42H45N13O7","InChI=1S/C42H45N13O7/c56-32(44-16-2-1-15-43-29-5-3-4-27-35(29)42(62)55(41(27)61)31-10-11-33(57)51-39(31)59)12-13-34(58)54-20-18-53(19-21-54)23-25-6-8-26(9-7-25)49-40(60)36-30(22-48-52-36)50-38-28-14-17-45-37(28)46-24-47-38/h3-9,14,17,22,24,31,43H,1-2,10-13,15-16,18-21,23H2,(H,44,56)(H,48,52)(H,49,60)(H,51,57,59)(H2,45,46,47,50)","TZBAAYPDIBJKIL-UHFFFAOYSA-N"
"611","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1380","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","843.906","843.35649078","1.99","62","8","13","7","16","259.61","C42H45N13O7","InChI=1S/C42H45N13O7/c56-32(44-16-2-1-15-43-29-5-3-4-27-35(29)42(62)55(41(27)61)31-10-11-33(57)51-39(31)59)12-13-34(58)54-20-18-53(19-21-54)23-25-6-8-26(9-7-25)49-40(60)36-30(22-48-52-36)50-38-28-14-17-45-37(28)46-24-47-38/h3-9,14,17,22,24,31,43H,1-2,10-13,15-16,18-21,23H2,(H,44,56)(H,48,52)(H,49,60)(H,51,57,59)(H2,45,46,47,50)","TZBAAYPDIBJKIL-UHFFFAOYSA-N"
"612","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3600","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","871.96","871.387790908","2.7","64","8","13","7","18","259.61","C44H49N13O7","InChI=1S/C44H49N13O7/c58-34(46-18-4-2-1-3-17-45-31-7-5-6-29-37(31)44(64)57(43(29)63)33-12-13-35(59)53-41(33)61)14-15-36(60)56-22-20-55(21-23-56)25-27-8-10-28(11-9-27)51-42(62)38-32(24-50-54-38)52-40-30-16-19-47-39(30)48-26-49-40/h5-11,16,19,24,26,33,45H,1-4,12-15,17-18,20-23,25H2,(H,46,58)(H,50,54)(H,51,62)(H,53,59,61)(H2,47,48,49,52)","LGNHFZATSNUGSF-UHFFFAOYSA-N"
"612","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3600","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","871.96","871.387790908","2.7","64","8","13","7","18","259.61","C44H49N13O7","InChI=1S/C44H49N13O7/c58-34(46-18-4-2-1-3-17-45-31-7-5-6-29-37(31)44(64)57(43(29)63)33-12-13-35(59)53-41(33)61)14-15-36(60)56-22-20-55(21-23-56)25-27-8-10-28(11-9-27)51-42(62)38-32(24-50-54-38)52-40-30-16-19-47-39(30)48-26-49-40/h5-11,16,19,24,26,33,45H,1-4,12-15,17-18,20-23,25H2,(H,46,58)(H,50,54)(H,51,62)(H,53,59,61)(H2,47,48,49,52)","LGNHFZATSNUGSF-UHFFFAOYSA-N"
"613","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8030","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","873.888","873.330669956","0.06","64","8","14","7","16","285.91","C42H43N13O9","InChI=1S/C42H43N13O9/c56-31(43-14-15-44-33(58)22-64-30-3-1-2-26-35(30)42(63)55(41(26)62)29-8-9-32(57)51-39(29)60)10-11-34(59)54-18-16-53(17-19-54)21-24-4-6-25(7-5-24)49-40(61)36-28(20-48-52-36)50-38-27-12-13-45-37(27)46-23-47-38/h1-7,12-13,20,23,29H,8-11,14-19,21-22H2,(H,43,56)(H,44,58)(H,48,52)(H,49,61)(H,51,57,60)(H2,45,46,47,50)","RXCNFYHHBZVFLZ-UHFFFAOYSA-N"
"613","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8030","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","873.888","873.330669956","0.06","64","8","14","7","16","285.91","C42H43N13O9","InChI=1S/C42H43N13O9/c56-31(43-14-15-44-33(58)22-64-30-3-1-2-26-35(30)42(63)55(41(26)62)29-8-9-32(57)51-39(29)60)10-11-34(59)54-18-16-53(17-19-54)21-24-4-6-25(7-5-24)49-40(61)36-28(20-48-52-36)50-38-27-12-13-45-37(27)46-23-47-38/h1-7,12-13,20,23,29H,8-11,14-19,21-22H2,(H,43,56)(H,44,58)(H,48,52)(H,49,61)(H,51,57,60)(H2,45,46,47,50)","RXCNFYHHBZVFLZ-UHFFFAOYSA-N"
"614","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13390","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","901.942","901.361970084","0.77","66","8","14","7","18","285.91","C44H47N13O9","InChI=1S/C44H47N13O9/c58-33(45-15-1-2-16-46-35(60)24-66-32-5-3-4-28-37(32)44(65)57(43(28)64)31-10-11-34(59)53-41(31)62)12-13-36(61)56-20-18-55(19-21-56)23-26-6-8-27(9-7-26)51-42(63)38-30(22-50-54-38)52-40-29-14-17-47-39(29)48-25-49-40/h3-9,14,17,22,25,31H,1-2,10-13,15-16,18-21,23-24H2,(H,45,58)(H,46,60)(H,50,54)(H,51,63)(H,53,59,62)(H2,47,48,49,52)","RXDRMOWDQPUCEN-UHFFFAOYSA-N"
"614","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13390","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","901.942","901.361970084","0.77","66","8","14","7","18","285.91","C44H47N13O9","InChI=1S/C44H47N13O9/c58-33(45-15-1-2-16-46-35(60)24-66-32-5-3-4-28-37(32)44(65)57(43(28)64)31-10-11-34(59)53-41(31)62)12-13-36(61)56-20-18-55(19-21-56)23-26-6-8-27(9-7-26)51-42(63)38-30(22-50-54-38)52-40-29-14-17-47-39(29)48-25-49-40/h3-9,14,17,22,25,31H,1-2,10-13,15-16,18-21,23-24H2,(H,45,58)(H,46,60)(H,50,54)(H,51,63)(H,53,59,62)(H2,47,48,49,52)","RXDRMOWDQPUCEN-UHFFFAOYSA-N"
"615","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7300","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","929.996","929.393270212","1.48","68","8","14","7","20","285.91","C46H51N13O9","InChI=1S/C46H51N13O9/c60-35(47-17-3-1-2-4-18-48-37(62)26-68-34-7-5-6-30-39(34)46(67)59(45(30)66)33-12-13-36(61)55-43(33)64)14-15-38(63)58-22-20-57(21-23-58)25-28-8-10-29(11-9-28)53-44(65)40-32(24-52-56-40)54-42-31-16-19-49-41(31)50-27-51-42/h5-11,16,19,24,27,33H,1-4,12-15,17-18,20-23,25-26H2,(H,47,60)(H,48,62)(H,52,56)(H,53,65)(H,55,61,64)(H2,49,50,51,54)","ZNSGBSSBUDPPPG-UHFFFAOYSA-N"
"615","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7300","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","929.996","929.393270212","1.48","68","8","14","7","20","285.91","C46H51N13O9","InChI=1S/C46H51N13O9/c60-35(47-17-3-1-2-4-18-48-37(62)26-68-34-7-5-6-30-39(34)46(67)59(45(30)66)33-12-13-36(61)55-43(33)64)14-15-38(63)58-22-20-57(21-23-58)25-28-8-10-29(11-9-28)53-44(65)40-32(24-52-56-40)54-42-31-16-19-49-41(31)50-27-51-42/h5-11,16,19,24,27,33H,1-4,12-15,17-18,20-23,25-26H2,(H,47,60)(H,48,62)(H,52,56)(H,53,65)(H,55,61,64)(H2,49,50,51,54)","ZNSGBSSBUDPPPG-UHFFFAOYSA-N"
"616","P24941","CDK2","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3540","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","876.888","876.330335608","0.61","64","8","15","6","18","275.27","C42H44N12O10","InChI=1S/C42H44N12O10/c55-32-9-8-30(39(58)50-32)54-41(60)27-2-1-3-31(35(27)42(54)61)64-22-33(56)43-12-17-62-18-19-63-23-34(57)53-15-13-52(14-16-53)21-25-4-6-26(7-5-25)48-40(59)36-29(20-47-51-36)49-38-28-10-11-44-37(28)45-24-46-38/h1-7,10-11,20,24,30H,8-9,12-19,21-23H2,(H,43,56)(H,47,51)(H,48,59)(H,50,55,58)(H2,44,45,46,49)","GIWSRJDJCKRGHO-UHFFFAOYSA-N"
"616","P50750","CDK9","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3540","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","876.888","876.330335608","0.61","64","8","15","6","18","275.27","C42H44N12O10","InChI=1S/C42H44N12O10/c55-32-9-8-30(39(58)50-32)54-41(60)27-2-1-3-31(35(27)42(54)61)64-22-33(56)43-12-17-62-18-19-63-23-34(57)53-15-13-52(14-16-53)21-25-4-6-26(7-5-25)48-40(59)36-29(20-47-51-36)49-38-28-10-11-44-37(28)45-24-46-38/h1-7,10-11,20,24,30H,8-9,12-19,21-23H2,(H,43,56)(H,47,51)(H,48,59)(H,50,55,58)(H2,44,45,46,49)","GIWSRJDJCKRGHO-UHFFFAOYSA-N"
"617","P24941","CDK2","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18340","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","1034.101","1033.44061433","0.33","75","8","17","7","27","313.6","C50H59N13O12","InChI=1S/C50H59N13O12/c64-39(12-13-42(67)62-20-18-61(19-21-62)29-32-6-8-33(9-7-32)57-48(69)44-36(28-56-60-44)58-46-35-14-17-53-45(35)54-31-55-46)51-15-2-22-72-24-26-74-27-25-73-23-3-16-52-41(66)30-75-38-5-1-4-34-43(38)50(71)63(49(34)70)37-10-11-40(65)59-47(37)68/h1,4-9,14,17,28,31,37H,2-3,10-13,15-16,18-27,29-30H2,(H,51,64)(H,52,66)(H,56,60)(H,57,69)(H,59,65,68)(H2,53,54,55,58)","BJAGLKVNYNKNRP-UHFFFAOYSA-N"
"617","P50750","CDK9","CRBN","","","O=C(CCC(=O)N1CCN(CC2=CC=C(NC(=O)C3=C(NC4=NC=NC5=C4C=C[NH]5)C=N[NH]3)C=C2)CC1)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18340","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.111952","1034.101","1033.44061433","0.33","75","8","17","7","27","313.6","C50H59N13O12","InChI=1S/C50H59N13O12/c64-39(12-13-42(67)62-20-18-61(19-21-62)29-32-6-8-33(9-7-32)57-48(69)44-36(28-56-60-44)58-46-35-14-17-53-45(35)54-31-55-46)51-15-2-22-72-24-26-74-27-25-73-23-3-16-52-41(66)30-75-38-5-1-4-34-43(38)50(71)63(49(34)70)37-10-11-40(65)59-47(37)68/h1,4-9,14,17,28,31,37H,2-3,10-13,15-16,18-27,29-30H2,(H,51,64)(H,52,66)(H,56,60)(H,57,69)(H,59,65,68)(H2,53,54,55,58)","BJAGLKVNYNKNRP-UHFFFAOYSA-N"
"618","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1486.282","1484.52083536","11.84","101","10","17","5","24","251.07","C73H88ClF3N10O10S4","InChI=1S/C73H88ClF3N10O10S4/c1-47(49-13-15-51(16-14-49)66-48(2)78-46-99-66)79-69(92)62-39-57(88)44-87(62)70(93)67(71(3,4)5)81-64(89)41-65(90)86-37-31-83(32-38-86)30-28-55(45-98-58-11-9-8-10-12-58)80-61-26-25-59(40-63(61)100(94,95)73(75,76)77)101(96,97)82-68(91)52-19-23-56(24-20-52)85-35-33-84(34-36-85)43-53-42-72(6,7)29-27-60(53)50-17-21-54(74)22-18-50/h8-26,40,46-47,55,57,62,67,80,88H,27-39,41-45H2,1-7H3,(H,79,92)(H,81,89)(H,82,91)/t47-,55+,57+,62-,67+/m0/s1","SXPDUCVNMGMWBJ-FMZBIETASA-N"
"619","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1500.309","1498.53648542","11.57","102","10","17","5","25","251.07","C74H90ClF3N10O10S4","InChI=1S/C74H90ClF3N10O10S4/c1-48(50-13-15-52(16-14-50)67-49(2)79-47-100-67)80-70(93)63-41-58(89)45-88(63)71(94)68(72(3,4)5)82-65(90)27-28-66(91)87-39-33-84(34-40-87)32-30-56(46-99-59-11-9-8-10-12-59)81-62-26-25-60(42-64(62)101(95,96)74(76,77)78)102(97,98)83-69(92)53-19-23-57(24-20-53)86-37-35-85(36-38-86)44-54-43-73(6,7)31-29-61(54)51-17-21-55(75)22-18-51/h8-26,42,47-48,56,58,63,68,81,89H,27-41,43-46H2,1-7H3,(H,80,93)(H,82,90)(H,83,92)/t48-,56+,58+,63-,68+/m0/s1","HQKUMELJMUNTTF-NMKDNUEVSA-N"
"620","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1514.336","1512.55213548","11.93","103","10","17","5","26","251.07","C75H92ClF3N10O10S4","InChI=1S/C75H92ClF3N10O10S4/c1-49(51-16-18-53(19-17-51)68-50(2)80-48-101-68)81-71(94)64-42-59(90)46-89(64)72(95)69(73(3,4)5)83-66(91)14-11-15-67(92)88-40-34-85(35-41-88)33-31-57(47-100-60-12-9-8-10-13-60)82-63-29-28-61(43-65(63)102(96,97)75(77,78)79)103(98,99)84-70(93)54-22-26-58(27-23-54)87-38-36-86(37-39-87)45-55-44-74(6,7)32-30-62(55)52-20-24-56(76)25-21-52/h8-10,12-13,16-29,43,48-49,57,59,64,69,82,90H,11,14-15,30-42,44-47H2,1-7H3,(H,81,94)(H,83,91)(H,84,93)/t49-,57+,59+,64-,69+/m0/s1","ATQCEJKUPSBDMA-QARNUTPLSA-N"
"621","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","467","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1528.363","1526.56778555","12.29","104","10","17","5","27","251.07","C76H94ClF3N10O10S4","InChI=1S/C76H94ClF3N10O10S4/c1-50(52-17-19-54(20-18-52)69-51(2)81-49-102-69)82-72(95)65-43-60(91)47-90(65)73(96)70(74(3,4)5)84-67(92)15-11-12-16-68(93)89-41-35-86(36-42-89)34-32-58(48-101-61-13-9-8-10-14-61)83-64-30-29-62(44-66(64)103(97,98)76(78,79)80)104(99,100)85-71(94)55-23-27-59(28-24-55)88-39-37-87(38-40-88)46-56-45-75(6,7)33-31-63(56)53-21-25-57(77)26-22-53/h8-10,13-14,17-30,44,49-50,58,60,65,70,83,91H,11-12,15-16,31-43,45-48H2,1-7H3,(H,82,95)(H,84,92)(H,85,94)/t50-,58+,60+,65-,70+/m0/s1","FNKQAGMHNFFSEI-DTTPTBRMSA-N"
"622","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","108","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1556.417","1554.59908568","13.37","106","10","17","5","29","251.07","C78H98ClF3N10O10S4","InChI=1S/C78H98ClF3N10O10S4/c1-52(54-19-21-56(22-20-54)71-53(2)83-51-104-71)84-74(97)67-45-62(93)49-92(67)75(98)72(76(3,4)5)86-69(94)17-13-8-9-14-18-70(95)91-43-37-88(38-44-91)36-34-60(50-103-63-15-11-10-12-16-63)85-66-32-31-64(46-68(66)105(99,100)78(80,81)82)106(101,102)87-73(96)57-25-29-61(30-26-57)90-41-39-89(40-42-90)48-58-47-77(6,7)35-33-65(58)55-23-27-59(79)28-24-55/h10-12,15-16,19-32,46,51-52,60,62,67,72,85,93H,8-9,13-14,17-18,33-45,47-50H2,1-7H3,(H,84,97)(H,86,94)(H,87,96)/t52-,60+,62+,67-,72+/m0/s1","DKBAKHBUQPFQDO-PXKQGBTKSA-N"
"623","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1500.353","1498.57287093","12.9","102","10","17","5","27","234.0","C75H94ClF3N10O9S4","InChI=1S/C75H94ClF3N10O9S4/c1-50(52-16-18-54(19-17-52)68-51(2)80-49-100-68)81-71(93)65-43-60(90)47-89(65)72(94)69(73(3,4)5)83-67(91)15-11-12-33-85-35-37-86(38-36-85)34-31-58(48-99-61-13-9-8-10-14-61)82-64-29-28-62(44-66(64)101(95,96)75(77,78)79)102(97,98)84-70(92)55-22-26-59(27-23-55)88-41-39-87(40-42-88)46-56-45-74(6,7)32-30-63(56)53-20-24-57(76)25-21-53/h8-10,13-14,16-29,44,49-50,58,60,65,69,82,90H,11-12,15,30-43,45-48H2,1-7H3,(H,81,93)(H,83,91)(H,84,92)/t50-,58+,60+,65-,69+/m0/s1","MNWLENHVZLVQFR-CBUJMEDQSA-N"
"624","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","93","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","82/76/203","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1514.38","1512.58852099","13.25","103","10","17","5","28","234.0","C76H96ClF3N10O9S4","InChI=1S/C76H96ClF3N10O9S4/c1-51(53-17-19-55(20-18-53)69-52(2)81-50-101-69)82-72(94)66-44-61(91)48-90(66)73(95)70(74(3,4)5)84-68(92)16-12-9-13-34-86-36-38-87(39-37-86)35-32-59(49-100-62-14-10-8-11-15-62)83-65-30-29-63(45-67(65)102(96,97)76(78,79)80)103(98,99)85-71(93)56-23-27-60(28-24-56)89-42-40-88(41-43-89)47-57-46-75(6,7)33-31-64(57)54-21-25-58(77)26-22-54/h8,10-11,14-15,17-30,45,50-51,59,61,66,70,83,91H,9,12-13,16,31-44,46-49H2,1-7H3,(H,82,94)(H,84,92)(H,85,93)/t51-,59+,61+,66-,70+/m0/s1","FQLHSKINBMZPFV-WTFVIAODSA-N"
"625","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","94.5","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1528.407","1526.60417106","13.79","104","10","17","5","29","234.0","C77H98ClF3N10O9S4","InChI=1S/C77H98ClF3N10O9S4/c1-52(54-18-20-56(21-19-54)70-53(2)82-51-102-70)83-73(95)67-45-62(92)49-91(67)74(96)71(75(3,4)5)85-69(93)17-13-8-9-14-35-87-37-39-88(40-38-87)36-33-60(50-101-63-15-11-10-12-16-63)84-66-31-30-64(46-68(66)103(97,98)77(79,80)81)104(99,100)86-72(94)57-24-28-61(29-25-57)90-43-41-89(42-44-90)48-58-47-76(6,7)34-32-65(58)55-22-26-59(78)27-23-55/h10-12,15-16,18-31,46,51-52,60,62,67,71,84,92H,8-9,13-14,17,32-45,47-50H2,1-7H3,(H,83,95)(H,85,93)(H,86,94)/t52-,60+,62+,67-,71+/m0/s1","PBJOAFRUOFGWDD-MPSCXWESSA-N"
"626","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","181","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1542.434","1540.61982112","14.34","105","10","17","5","30","234.0","C78H100ClF3N10O9S4","InChI=1S/C78H100ClF3N10O9S4/c1-53(55-19-21-57(22-20-55)71-54(2)83-52-103-71)84-74(96)68-46-63(93)50-92(68)75(97)72(76(3,4)5)86-70(94)18-14-9-8-10-15-36-88-38-40-89(41-39-88)37-34-61(51-102-64-16-12-11-13-17-64)85-67-32-31-65(47-69(67)104(98,99)78(80,81)82)105(100,101)87-73(95)58-25-29-62(30-26-58)91-44-42-90(43-45-91)49-59-48-77(6,7)35-33-66(59)56-23-27-60(79)28-24-56/h11-13,16-17,19-32,47,52-53,61,63,68,72,85,93H,8-10,14-15,18,33-46,48-51H2,1-7H3,(H,84,96)(H,86,94)(H,87,95)/t53-,61+,63+,68-,72+/m0/s1","OUIMYXTZMDHHNX-SBLJYMSTSA-N"
"627","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","324","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1544.362","1542.56270017","11.43","105","10","18","5","28","260.3","C76H94ClF3N10O11S4","InChI=1S/C76H94ClF3N10O11S4/c1-50(52-13-15-54(16-14-52)69-51(2)81-49-103-69)82-72(95)65-43-60(91)47-90(65)73(96)70(74(3,4)5)84-67(92)29-41-101-42-30-68(93)89-39-33-86(34-40-89)32-28-58(48-102-61-11-9-8-10-12-61)83-64-26-25-62(44-66(64)104(97,98)76(78,79)80)105(99,100)85-71(94)55-19-23-59(24-20-55)88-37-35-87(36-38-88)46-56-45-75(6,7)31-27-63(56)53-17-21-57(77)22-18-53/h8-26,44,49-50,58,60,65,70,83,91H,27-43,45-48H2,1-7H3,(H,82,95)(H,84,92)(H,85,94)/t50-,58+,60+,65-,70+/m0/s1","HDXOQCZIORATOK-DTTPTBRMSA-N"
"628","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","512","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1560.361","1558.55761479","11.47","106","10","19","5","29","269.53","C76H94ClF3N10O12S4","InChI=1S/C76H94ClF3N10O12S4/c1-50(52-13-15-54(16-14-52)69-51(2)81-49-104-69)82-72(95)65-41-60(91)45-90(65)73(96)70(74(3,4)5)84-67(92)46-101-39-40-102-47-68(93)89-37-31-86(32-38-89)30-28-58(48-103-61-11-9-8-10-12-61)83-64-26-25-62(42-66(64)105(97,98)76(78,79)80)106(99,100)85-71(94)55-19-23-59(24-20-55)88-35-33-87(34-36-88)44-56-43-75(6,7)29-27-63(56)53-17-21-57(77)22-18-53/h8-26,42,49-50,58,60,65,70,83,91H,27-41,43-48H2,1-7H3,(H,82,95)(H,84,92)(H,85,94)/t50-,58+,60+,65-,70+/m0/s1","OFWNLGXWCMBGST-DTTPTBRMSA-N"
"629","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","232","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1574.388","1572.57326485","11.83","107","10","19","5","30","269.53","C77H96ClF3N10O12S4","InChI=1S/C77H96ClF3N10O12S4/c1-51(53-14-16-55(17-15-53)70-52(2)82-50-105-70)83-73(96)66-42-61(92)46-91(66)74(97)71(75(3,4)5)85-68(93)47-102-40-11-41-103-48-69(94)90-38-32-87(33-39-90)31-29-59(49-104-62-12-9-8-10-13-62)84-65-27-26-63(43-67(65)106(98,99)77(79,80)81)107(100,101)86-72(95)56-20-24-60(25-21-56)89-36-34-88(35-37-89)45-57-44-76(6,7)30-28-64(57)54-18-22-58(78)23-19-54/h8-10,12-27,43,50-51,59,61,66,71,84,92H,11,28-42,44-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1","UJJQCEGVBXMBFD-REQIQPEASA-N"
"630","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","151","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1516.352","1514.56778555","12.03","103","10","18","5","28","243.23","C75H94ClF3N10O10S4","InChI=1S/C75H94ClF3N10O10S4/c1-50(52-13-15-54(16-14-52)68-51(2)80-49-101-68)81-71(93)65-43-60(90)47-89(65)72(94)69(73(3,4)5)83-67(91)29-41-99-42-40-86-34-32-85(33-35-86)31-28-58(48-100-61-11-9-8-10-12-61)82-64-26-25-62(44-66(64)102(95,96)75(77,78)79)103(97,98)84-70(92)55-19-23-59(24-20-55)88-38-36-87(37-39-88)46-56-45-74(6,7)30-27-63(56)53-17-21-57(76)22-18-53/h8-26,44,49-50,58,60,65,69,82,90H,27-43,45-48H2,1-7H3,(H,81,93)(H,83,91)(H,84,92)/t50-,58+,60+,65-,69+/m0/s1","NLWOQGWFAZXXJL-CBUJMEDQSA-N"
"631","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCN3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","914","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1560.405","1558.5940003","11.89","106","10","19","5","31","252.46","C77H98ClF3N10O11S4","InChI=1S/C77H98ClF3N10O11S4/c1-52(54-13-15-56(16-14-54)70-53(2)82-51-104-70)83-73(95)67-45-62(92)49-91(67)74(96)71(75(3,4)5)85-69(93)29-41-101-43-44-102-42-40-88-34-32-87(33-35-88)31-28-60(50-103-63-11-9-8-10-12-63)84-66-26-25-64(46-68(66)105(97,98)77(79,80)81)106(99,100)86-72(94)57-19-23-61(24-20-57)90-38-36-89(37-39-90)48-58-47-76(6,7)30-27-65(58)55-17-21-59(78)22-18-55/h8-26,46,51-52,60,62,67,71,84,92H,27-45,47-50H2,1-7H3,(H,83,95)(H,85,93)(H,86,94)/t52-,60+,62+,67-,71+/m0/s1","HRKCLOAGRMYKFF-MPSCXWESSA-N"
"632","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1487.31","1485.54123645","13.02","101","9","16","5","28","247.83","C74H91ClF3N9O10S4","InChI=1S/C74H91ClF3N9O10S4/c1-48(50-19-21-52(22-20-50)67-49(2)79-47-99-67)80-70(92)63-41-58(88)45-87(63)71(93)68(72(3,4)5)82-65(89)17-13-10-14-18-66(90)84(8)36-34-56(46-98-59-15-11-9-12-16-59)81-62-32-31-60(42-64(62)100(94,95)74(76,77)78)101(96,97)83-69(91)53-25-29-57(30-26-53)86-39-37-85(38-40-86)44-54-43-73(6,7)35-33-61(54)51-23-27-55(75)28-24-51/h9,11-12,15-16,19-32,42,47-48,56,58,63,68,81,88H,10,13-14,17-18,33-41,43-46H2,1-8H3,(H,80,92)(H,82,89)(H,83,91)/t48-,56+,58+,63-,68+/m0/s1","KYTMKSFBNSZWNK-NMKDNUEVSA-N"
"633","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1243","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1445.273","1443.53067177","13.08","98","9","16","5","27","230.76","C72H89ClF3N9O9S4","InChI=1S/C72H89ClF3N9O9S4/c1-47(49-17-19-51(20-18-49)65-48(2)77-46-96-65)78-68(89)62-40-57(86)44-85(62)69(90)66(70(3,4)5)80-64(87)16-12-13-34-82(8)35-32-55(45-95-58-14-10-9-11-15-58)79-61-30-29-59(41-63(61)97(91,92)72(74,75)76)98(93,94)81-67(88)52-23-27-56(28-24-52)84-38-36-83(37-39-84)43-53-42-71(6,7)33-31-60(53)50-21-25-54(73)26-22-50/h9-11,14-15,17-30,41,46-47,55,57,62,66,79,86H,12-13,16,31-40,42-45H2,1-8H3,(H,78,89)(H,80,87)(H,81,88)/t47-,55+,57+,62-,66+/m0/s1","YTRWDKQNAYLSGE-YCFILJOBSA-N"
"634","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","460","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1459.3","1457.54632183","13.44","99","9","16","5","28","230.76","C73H91ClF3N9O9S4","InChI=1S/C73H91ClF3N9O9S4/c1-48(50-18-20-52(21-19-50)66-49(2)78-47-97-66)79-69(90)63-41-58(87)45-86(63)70(91)67(71(3,4)5)81-65(88)17-13-10-14-35-83(8)36-33-56(46-96-59-15-11-9-12-16-59)80-62-31-30-60(42-64(62)98(92,93)73(75,76)77)99(94,95)82-68(89)53-24-28-57(29-25-53)85-39-37-84(38-40-85)44-54-43-72(6,7)34-32-61(54)51-22-26-55(74)27-23-51/h9,11-12,15-16,18-31,42,47-48,56,58,63,67,80,87H,10,13-14,17,32-41,43-46H2,1-8H3,(H,79,90)(H,81,88)(H,82,89)/t48-,56+,58+,63-,67+/m0/s1","GBBMGZHROSWSAK-RTWFSMGLSA-N"
"635","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","71","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","81.3/189/265","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1473.327","1471.5619719","13.98","100","9","16","5","29","230.76","C74H93ClF3N9O9S4","InChI=1S/C74H93ClF3N9O9S4/c1-49(51-19-21-53(22-20-51)67-50(2)79-48-98-67)80-70(91)64-42-59(88)46-87(64)71(92)68(72(3,4)5)82-66(89)18-14-9-10-15-36-84(8)37-34-57(47-97-60-16-12-11-13-17-60)81-63-32-31-61(43-65(63)99(93,94)74(76,77)78)100(95,96)83-69(90)54-25-29-58(30-26-54)86-40-38-85(39-41-86)45-55-44-73(6,7)35-33-62(55)52-23-27-56(75)28-24-52/h11-13,16-17,19-32,43,48-49,57,59,64,68,81,88H,9-10,14-15,18,33-42,44-47H2,1-8H3,(H,80,91)(H,82,89)(H,83,90)/t49-,57+,59+,64-,68+/m0/s1","CZOKQVGGYUWHCE-OIWNBYFASA-N"
"636","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","147","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1487.354","1485.57762196","14.52","101","9","16","5","30","230.76","C75H95ClF3N9O9S4","InChI=1S/C75H95ClF3N9O9S4/c1-50(52-20-22-54(23-21-52)68-51(2)80-49-99-68)81-71(92)65-43-60(89)47-88(65)72(93)69(73(3,4)5)83-67(90)19-15-10-9-11-16-37-85(8)38-35-58(48-98-61-17-13-12-14-18-61)82-64-33-32-62(44-66(64)100(94,95)75(77,78)79)101(96,97)84-70(91)55-26-30-59(31-27-55)87-41-39-86(40-42-87)46-56-45-74(6,7)36-34-63(56)53-24-28-57(76)29-25-53/h12-14,17-18,20-33,44,49-50,58,60,65,69,82,89H,9-11,15-16,19,34-43,45-48H2,1-8H3,(H,81,92)(H,83,90)(H,84,91)/t50-,58+,60+,65-,69+/m0/s1","COTDHKITQDEMPJ-CBUJMEDQSA-N"
"637","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","139","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1501.381","1499.59327202","15.07","102","9","16","5","31","230.76","C76H97ClF3N9O9S4","InChI=1S/C76H97ClF3N9O9S4/c1-51(53-21-23-55(24-22-53)69-52(2)81-50-100-69)82-72(93)66-44-61(90)48-89(66)73(94)70(74(3,4)5)84-68(91)20-16-11-9-10-12-17-38-86(8)39-36-59(49-99-62-18-14-13-15-19-62)83-65-34-33-63(45-67(65)101(95,96)76(78,79)80)102(97,98)85-71(92)56-27-31-60(32-28-56)88-42-40-87(41-43-88)47-57-46-75(6,7)37-35-64(57)54-25-29-58(77)30-26-54/h13-15,18-19,21-34,45,50-51,59,61,66,70,83,90H,9-12,16-17,20,35-44,46-49H2,1-8H3,(H,82,93)(H,84,91)(H,85,92)/t51-,59+,61+,66-,70+/m0/s1","QGIHCDHERIYZCE-WTFVIAODSA-N"
"638","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1058","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1515.408","1513.60892209","15.61","103","9","16","5","32","230.76","C77H99ClF3N9O9S4","InChI=1S/C77H99ClF3N9O9S4/c1-52(54-22-24-56(25-23-54)70-53(2)82-51-101-70)83-73(94)67-45-62(91)49-90(67)74(95)71(75(3,4)5)85-69(92)21-17-12-10-9-11-13-18-39-87(8)40-37-60(50-100-63-19-15-14-16-20-63)84-66-35-34-64(46-68(66)102(96,97)77(79,80)81)103(98,99)86-72(93)57-28-32-61(33-29-57)89-43-41-88(42-44-89)48-58-47-76(6,7)38-36-65(58)55-26-30-59(78)31-27-55/h14-16,19-20,22-35,46,51-52,60,62,67,71,84,91H,9-13,17-18,21,36-45,47-50H2,1-8H3,(H,83,94)(H,85,92)(H,86,93)/t52-,60+,62+,67-,71+/m0/s1","GUVWVFBOZDKGPN-MPSCXWESSA-N"
"639","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","97","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1491.298","1489.53615107","12.17","101","9","18","5","30","249.22","C73H91ClF3N9O11S4","InChI=1S/C73H91ClF3N9O11S4/c1-48(50-14-16-52(17-15-50)66-49(2)78-47-99-66)79-69(90)63-40-58(87)44-86(63)70(91)67(71(3,4)5)81-65(88)45-97-39-38-96-37-36-83(8)31-29-56(46-98-59-12-10-9-11-13-59)80-62-27-26-60(41-64(62)100(92,93)73(75,76)77)101(94,95)82-68(89)53-20-24-57(25-21-53)85-34-32-84(33-35-85)43-54-42-72(6,7)30-28-61(54)51-18-22-55(74)23-19-51/h9-27,41,47-48,56,58,63,67,80,87H,28-40,42-46H2,1-8H3,(H,79,90)(H,81,88)(H,82,89)/t48-,56+,58+,63-,67+/m0/s1","YZKSVTCTERXXBV-RTWFSMGLSA-N"
"640","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","200","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1535.351","1533.56236582","12.02","104","9","19","5","33","258.45","C75H95ClF3N9O12S4","InChI=1S/C75H95ClF3N9O12S4/c1-50(52-14-16-54(17-15-52)68-51(2)80-49-102-68)81-71(92)65-42-60(89)46-88(65)72(93)69(73(3,4)5)83-67(90)47-100-41-40-99-39-38-98-37-36-85(8)31-29-58(48-101-61-12-10-9-11-13-61)82-64-27-26-62(43-66(64)103(94,95)75(77,78)79)104(96,97)84-70(91)55-20-24-59(25-21-55)87-34-32-86(33-35-87)45-56-44-74(6,7)30-28-63(56)53-18-22-57(76)23-19-53/h9-27,43,49-50,58,60,65,69,82,89H,28-42,44-48H2,1-8H3,(H,81,92)(H,83,90)(H,84,91)/t50-,58+,60+,65-,69+/m0/s1","ZAFNNYSTUOKHGV-CBUJMEDQSA-N"
"641","Q07817","BCL-xL","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN(C)CC[C@H](CSC3=CC=CC=C3)NC3=CC=C(S(=O)(=O)NC(=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4)C=C3S(=O)(=O)C(F)(F)F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","206","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1579.404","1577.58858057","11.88","107","9","20","5","36","267.68","C77H99ClF3N9O13S4","InChI=1S/C77H99ClF3N9O13S4/c1-52(54-14-16-56(17-15-54)70-53(2)82-51-105-70)83-73(94)67-44-62(91)48-90(67)74(95)71(75(3,4)5)85-69(92)49-103-43-42-102-41-40-101-39-38-100-37-36-87(8)31-29-60(50-104-63-12-10-9-11-13-63)84-66-27-26-64(45-68(66)106(96,97)77(79,80)81)107(98,99)86-72(93)57-20-24-61(25-21-57)89-34-32-88(33-35-89)47-58-46-76(6,7)30-28-65(58)55-18-22-59(78)23-19-55/h9-27,45,51-52,60,62,67,71,84,91H,28-44,46-50H2,1-8H3,(H,83,94)(H,85,92)(H,86,93)/t52-,60+,62+,67-,71+/m0/s1","UWBJXTYZYNIZJH-MPSCXWESSA-N"
"642","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)CCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","82","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1314.973","1313.41266481","9.95","90","10","16","4","22","235.02","C64H71ClF3N9O10S3","InChI=1S/C64H71ClF3N9O10S3/c1-63(2)27-25-50(42-13-17-45(65)18-14-42)44(39-63)40-74-32-34-75(35-33-74)47-19-15-43(16-20-47)59(80)72-90(86,87)49-21-22-52(55(38-49)89(84,85)64(66,67)68)70-46(41-88-48-8-4-3-5-9-48)26-29-73-30-36-76(37-31-73)57(79)12-7-28-69-53-11-6-10-51-58(53)62(83)77(61(51)82)54-23-24-56(78)71-60(54)81/h3-6,8-11,13-22,38,46,54,69-70H,7,12,23-37,39-41H2,1-2H3,(H,72,80)(H,71,78,81)/t46-,54?/m1/s1","GQLOKACUFGETGD-MFJGLPAGSA-N"
"643","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)CCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","346","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1329.0","1327.42831488","10.3","91","10","16","4","23","235.02","C65H73ClF3N9O10S3","InChI=1S/C65H73ClF3N9O10S3/c1-64(2)28-26-51(43-14-18-46(66)19-15-43)45(40-64)41-75-33-35-76(36-34-75)48-20-16-44(17-21-48)60(81)73-91(87,88)50-22-23-53(56(39-50)90(85,86)65(67,68)69)71-47(42-89-49-9-4-3-5-10-49)27-30-74-31-37-77(38-32-74)58(80)13-6-7-29-70-54-12-8-11-52-59(54)63(84)78(62(52)83)55-24-25-57(79)72-61(55)82/h3-5,8-12,14-23,39,47,55,70-71H,6-7,13,24-38,40-42H2,1-2H3,(H,73,81)(H,72,79,82)/t47-,55?/m1/s1","FWKWJVPLMFFODU-IQRNJRIOSA-N"
"644","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)CCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","518","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1343.027","1341.44396494","10.66","92","10","16","4","24","235.02","C66H75ClF3N9O10S3","InChI=1S/C66H75ClF3N9O10S3/c1-65(2)29-27-52(44-15-19-47(67)20-16-44)46(41-65)42-76-34-36-77(37-35-76)49-21-17-45(18-22-49)61(82)74-92(88,89)51-23-24-54(57(40-51)91(86,87)66(68,69)70)72-48(43-90-50-10-5-3-6-11-50)28-31-75-32-38-78(39-33-75)59(81)14-7-4-8-30-71-55-13-9-12-53-60(55)64(85)79(63(53)84)56-25-26-58(80)73-62(56)83/h3,5-6,9-13,15-24,40,48,56,71-72H,4,7-8,14,25-39,41-43H2,1-2H3,(H,74,82)(H,73,80,83)/t48-,56?/m1/s1","LSWTUTVGIXUPJZ-YJUSKGKKSA-N"
"645","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)CCCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1357.054","1355.459615","11.2","93","10","16","4","25","235.02","C67H77ClF3N9O10S3","InChI=1S/C67H77ClF3N9O10S3/c1-66(2)30-28-53(45-16-20-48(68)21-17-45)47(42-66)43-77-35-37-78(38-36-77)50-22-18-46(19-23-50)62(83)75-93(89,90)52-24-25-55(58(41-52)92(87,88)67(69,70)71)73-49(44-91-51-11-6-5-7-12-51)29-32-76-33-39-79(40-34-76)60(82)15-8-3-4-9-31-72-56-14-10-13-54-61(56)65(86)80(64(54)85)57-26-27-59(81)74-63(57)84/h5-7,10-14,16-25,41,49,57,72-73H,3-4,8-9,15,26-40,42-44H2,1-2H3,(H,75,83)(H,74,81,84)/t49-,57?/m1/s1","VEDAFKYSIRBOFV-LKVFYHIZSA-N"
"646","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)CCCCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1371.081","1369.47526507","11.74","94","10","16","4","26","235.02","C68H79ClF3N9O10S3","InChI=1S/C68H79ClF3N9O10S3/c1-67(2)31-29-54(46-17-21-49(69)22-18-46)48(43-67)44-78-36-38-79(39-37-78)51-23-19-47(20-24-51)63(84)76-94(90,91)53-25-26-56(59(42-53)93(88,89)68(70,71)72)74-50(45-92-52-12-7-6-8-13-52)30-33-77-34-40-80(41-35-77)61(83)16-9-4-3-5-10-32-73-57-15-11-14-55-62(57)66(87)81(65(55)86)58-27-28-60(82)75-64(58)85/h6-8,11-15,17-26,42,50,58,73-74H,3-5,9-10,16,27-41,43-45H2,1-2H3,(H,76,84)(H,75,82,85)/t50-,58?/m1/s1","KISACIPNHFVERP-XIMDYXIDSA-N"
"647","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28.3","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1286.963","1285.41775019","10.55","88","10","16","4","22","217.95","C63H71ClF3N9O9S3","InChI=1S/C63H71ClF3N9O9S3/c1-62(2)26-24-50(42-12-16-45(64)17-13-42)44(39-62)40-74-34-36-75(37-35-74)47-18-14-43(15-19-47)58(78)71-88(84,85)49-20-21-52(55(38-49)87(82,83)63(65,66)67)69-46(41-86-48-8-4-3-5-9-48)25-29-73-32-30-72(31-33-73)28-7-27-68-53-11-6-10-51-57(53)61(81)76(60(51)80)54-22-23-56(77)70-59(54)79/h3-6,8-21,38,46,54,68-69H,7,22-37,39-41H2,1-2H3,(H,71,78)(H,70,77,79)/t46-,54?/m1/s1","MDZKHUBASDDMDH-MFJGLPAGSA-N"
"648","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1300.99","1299.43340026","10.91","89","10","16","4","23","217.95","C64H73ClF3N9O9S3","InChI=1S/C64H73ClF3N9O9S3/c1-63(2)27-25-51(43-13-17-46(65)18-14-43)45(40-63)41-75-35-37-76(38-36-75)48-19-15-44(16-20-48)59(79)72-89(85,86)50-21-22-53(56(39-50)88(83,84)64(66,67)68)70-47(42-87-49-9-4-3-5-10-49)26-30-74-33-31-73(32-34-74)29-7-6-28-69-54-12-8-11-52-58(54)62(82)77(61(52)81)55-23-24-57(78)71-60(55)80/h3-5,8-22,39,47,55,69-70H,6-7,23-38,40-42H2,1-2H3,(H,72,79)(H,71,78,80)/t47-,55?/m1/s1","QTSAZGUNTDTOIP-IQRNJRIOSA-N"
"649","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","100","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1315.017","1313.44905032","11.27","90","10","16","4","24","217.95","C65H75ClF3N9O9S3","InChI=1S/C65H75ClF3N9O9S3/c1-64(2)28-26-52(44-14-18-47(66)19-15-44)46(41-64)42-76-36-38-77(39-37-76)49-20-16-45(17-21-49)60(80)73-90(86,87)51-22-23-54(57(40-51)89(84,85)65(67,68)69)71-48(43-88-50-10-5-3-6-11-50)27-31-75-34-32-74(33-35-75)30-8-4-7-29-70-55-13-9-12-53-59(55)63(83)78(62(53)82)56-24-25-58(79)72-61(56)81/h3,5-6,9-23,40,48,56,70-71H,4,7-8,24-39,41-43H2,1-2H3,(H,73,80)(H,72,79,81)/t48-,56?/m1/s1","YBFNQIRBVZVRKS-YJUSKGKKSA-N"
"650","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)COCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","161","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1375.025","1373.43379418","9.39","94","10","18","4","26","253.48","C66H75ClF3N9O12S3","InChI=1S/C66H75ClF3N9O12S3/c1-65(2)25-23-52(44-11-15-47(67)16-12-44)46(40-65)41-76-30-32-77(33-31-76)49-17-13-45(14-18-49)61(82)74-94(88,89)51-19-20-54(57(39-51)93(86,87)66(68,69)70)72-48(43-92-50-7-4-3-5-8-50)24-27-75-28-34-78(35-29-75)59(81)42-91-38-37-90-36-26-71-55-10-6-9-53-60(55)64(85)79(63(53)84)56-21-22-58(80)73-62(56)83/h3-20,39,48,56,71-72H,21-38,40-43H2,1-2H3,(H,74,82)(H,73,80,83)/t48-,56?/m1/s1","VJVKHPKQMHHKQT-YJUSKGKKSA-N"
"651","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)COCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","211","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1419.078","1417.46000893","9.24","97","10","19","4","29","262.71","C68H79ClF3N9O13S3","InChI=1S/C68H79ClF3N9O13S3/c1-67(2)25-23-54(46-11-15-49(69)16-12-46)48(42-67)43-78-30-32-79(33-31-78)51-17-13-47(14-18-51)63(84)76-97(90,91)53-19-20-56(59(41-53)96(88,89)68(70,71)72)74-50(45-95-52-7-4-3-5-8-52)24-27-77-28-34-80(35-29-77)61(83)44-94-40-39-93-38-37-92-36-26-73-57-10-6-9-55-62(57)66(87)81(65(55)86)58-21-22-60(82)75-64(58)85/h3-20,41,50,58,73-74H,21-40,42-45H2,1-2H3,(H,76,84)(H,75,82,85)/t50-,58?/m1/s1","AAJKURLKPBZSFJ-XIMDYXIDSA-N"
"652","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)COCCOCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","126","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1463.131","1461.48622368","9.1","100","10","20","4","32","271.94","C70H83ClF3N9O14S3","InChI=1S/C70H83ClF3N9O14S3/c1-69(2)25-23-56(48-11-15-51(71)16-12-48)50(44-69)45-80-30-32-81(33-31-80)53-17-13-49(14-18-53)65(86)78-100(92,93)55-19-20-58(61(43-55)99(90,91)70(72,73)74)76-52(47-98-54-7-4-3-5-8-54)24-27-79-28-34-82(35-29-79)63(85)46-97-42-41-96-40-39-95-38-37-94-36-26-75-59-10-6-9-57-64(59)68(89)83(67(57)88)60-21-22-62(84)77-66(60)87/h3-20,43,52,60,75-76H,21-42,44-47H2,1-2H3,(H,78,86)(H,77,84,87)/t52-,60?/m1/s1","CLCZSXCUDOOMIF-WHNYYDPKSA-N"
"653","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=O)NCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","118","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1404.067","1402.46034328","9.19","96","10","18","5","27","265.51","C67H78ClF3N10O12S3","InChI=1S/C67H78ClF3N10O12S3/c1-66(2)25-23-53(45-11-15-48(68)16-12-45)47(42-66)43-78-31-33-79(34-32-78)50-17-13-46(14-18-50)61(83)76-96(90,91)52-19-20-55(58(41-52)95(88,89)67(69,70)71)74-49(44-94-51-7-4-3-5-8-51)24-28-77-29-35-80(36-30-77)65(87)73-27-38-93-40-39-92-37-26-72-56-10-6-9-54-60(56)64(86)81(63(54)85)57-21-22-59(82)75-62(57)84/h3-20,41,49,57,72,74H,21-40,42-44H2,1-2H3,(H,73,87)(H,76,83)(H,75,82,84)/t49-,57?/m1/s1","HUJOFFBNGNRZLG-LKVFYHIZSA-N"
"654","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(C(=S)NCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","722","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1420.135","1418.43749966","9.79","96","10","18","5","27","248.44","C67H78ClF3N10O11S4","InChI=1S/C67H78ClF3N10O11S4/c1-66(2)25-23-53(45-11-15-48(68)16-12-45)47(42-66)43-78-31-33-79(34-32-78)50-17-13-46(14-18-50)61(83)76-96(89,90)52-19-20-55(58(41-52)95(87,88)67(69,70)71)74-49(44-94-51-7-4-3-5-8-51)24-28-77-29-35-80(36-30-77)65(93)73-27-38-92-40-39-91-37-26-72-56-10-6-9-54-60(56)64(86)81(63(54)85)57-21-22-59(82)75-62(57)84/h3-20,41,49,57,72,74H,21-40,42-44H2,1-2H3,(H,73,93)(H,76,83)(H,75,82,84)/t49-,57?/m1/s1","SLGLVPOGJGXKNW-LKVFYHIZSA-N"
"655","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","60.5","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1316.989","1315.42831488","10.05","90","10","17","4","24","227.18","C64H73ClF3N9O10S3","InChI=1S/C64H73ClF3N9O10S3/c1-63(2)25-23-51(43-11-15-46(65)16-12-43)45(40-63)41-75-32-34-76(35-33-75)48-17-13-44(14-18-48)59(79)72-90(85,86)50-19-20-53(56(39-50)89(83,84)64(66,67)68)70-47(42-88-49-7-4-3-5-8-49)24-27-73-28-30-74(31-29-73)36-38-87-37-26-69-54-10-6-9-52-58(54)62(82)77(61(52)81)55-21-22-57(78)71-60(55)80/h3-20,39,47,55,69-70H,21-38,40-42H2,1-2H3,(H,72,79)(H,71,78,80)/t47-,55?/m1/s1","IYIOGVQABFXBJW-IQRNJRIOSA-N"
"656","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41.4","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1361.042","1359.45452962","9.9","93","10","18","4","27","236.41","C66H77ClF3N9O11S3","InChI=1S/C66H77ClF3N9O11S3/c1-65(2)25-23-53(45-11-15-48(67)16-12-45)47(42-65)43-77-32-34-78(35-33-77)50-17-13-46(14-18-50)61(81)74-93(87,88)52-19-20-55(58(41-52)92(85,86)66(68,69)70)72-49(44-91-51-7-4-3-5-8-51)24-27-75-28-30-76(31-29-75)36-38-90-40-39-89-37-26-71-56-10-6-9-54-60(56)64(84)79(63(54)83)57-21-22-59(80)73-62(57)82/h3-20,41,49,57,71-72H,21-40,42-44H2,1-2H3,(H,74,81)(H,73,80,82)/t49-,57?/m1/s1","DYOGHZZIPKJNPD-LKVFYHIZSA-N"
"657","Q07817","BCL-xL","CRBN","","","CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(CN2CCN(C3=CC=C(C(=O)NS(=O)(=O)C4=CC=C(N[C@H](CCN5CCN(CCOCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSC5=CC=CC=C5)C(S(=O)(=O)C(F)(F)F)=C4)C=C3)CC2)C1","4.5","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17.3/38.5/24.6","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1405.095","1403.48074437","9.75","96","10","19","4","30","245.64","C68H81ClF3N9O12S3","InChI=1S/C68H81ClF3N9O12S3/c1-67(2)25-23-55(47-11-15-50(69)16-12-47)49(44-67)45-79-32-34-80(35-33-79)52-17-13-48(14-18-52)63(83)76-96(89,90)54-19-20-57(60(43-54)95(87,88)68(70,71)72)74-51(46-94-53-7-4-3-5-8-53)24-27-77-28-30-78(31-29-77)36-38-92-40-42-93-41-39-91-37-26-73-58-10-6-9-56-62(58)66(86)81(65(56)85)59-21-22-61(82)75-64(59)84/h3-20,43,51,59,73-74H,21-42,44-46H2,1-2H3,(H,76,83)(H,75,82,84)/t51-,59?/m1/s1","NCWWDSSVLZQYKO-HTEBOMBNSA-N"
"658","Q07817","BCL-xL","CRBN","","","CN(CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F)C(=O)CCCN1C=C(COCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","770","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1429.077","1427.45559224","9.07","98","10","20","4","30","280.95","C68H77ClF3N11O12S3","InChI=1S/C68H77ClF3N11O12S3/c1-67(2)28-26-54(45-14-18-48(69)19-15-45)47(40-67)41-80-32-34-81(35-33-80)51-20-16-46(17-21-51)63(86)77-98(92,93)53-22-23-56(59(39-53)97(90,91)68(70,71)72)74-49(44-96-52-9-5-4-6-10-52)27-31-79(3)61(85)13-8-30-82-42-50(76-78-82)43-95-38-37-94-36-29-73-57-12-7-11-55-62(57)66(89)83(65(55)88)58-24-25-60(84)75-64(58)87/h4-7,9-12,14-23,39,42,49,58,73-74H,8,13,24-38,40-41,43-44H2,1-3H3,(H,77,86)(H,75,84,87)/t49-,58?/m1/s1","CUFRZHWTZNFONB-BAHIOSHZSA-N"
"659","Q07817","BCL-xL","CRBN","","","CN(CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F)C(=O)CCCN1C=C(COCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","769","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1473.13","1471.48180699","8.92","101","10","21","4","33","290.18","C70H81ClF3N11O13S3","InChI=1S/C70H81ClF3N11O13S3/c1-69(2)28-26-56(47-14-18-50(71)19-15-47)49(42-69)43-82-32-34-83(35-33-82)53-20-16-48(17-21-53)65(88)79-101(94,95)55-22-23-58(61(41-55)100(92,93)70(72,73)74)76-51(46-99-54-9-5-4-6-10-54)27-31-81(3)63(87)13-8-30-84-44-52(78-80-84)45-98-40-39-97-38-37-96-36-29-75-59-12-7-11-57-64(59)68(91)85(67(57)90)60-24-25-62(86)77-66(60)89/h4-7,9-12,14-23,41,44,51,60,75-76H,8,13,24-40,42-43,45-46H2,1-3H3,(H,79,88)(H,77,86,89)/t51-,60?/m1/s1","FBVCBNKKRKGJFG-MBIIPZRXSA-N"
"660","Q07817","BCL-xL","CRBN","","","CN(CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F)C(=O)CCCCCCN1C=C(COCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","177","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1471.158","1469.50254244","10.33","101","10","20","4","33","280.95","C71H83ClF3N11O12S3","InChI=1S/C71H83ClF3N11O12S3/c1-70(2)31-29-57(48-17-21-51(72)22-18-48)50(43-70)44-83-35-37-84(38-36-83)54-23-19-49(20-24-54)66(89)80-101(95,96)56-25-26-59(62(42-56)100(93,94)71(73,74)75)77-52(47-99-55-12-7-6-8-13-55)30-34-82(3)64(88)16-9-4-5-10-33-85-45-53(79-81-85)46-98-41-40-97-39-32-76-60-15-11-14-58-65(60)69(92)86(68(58)91)61-27-28-63(87)78-67(61)90/h6-8,11-15,17-26,42,45,52,61,76-77H,4-5,9-10,16,27-41,43-44,46-47H2,1-3H3,(H,80,89)(H,78,87,90)/t52-,61?/m1/s1","QCTMCAHHNATDGH-ADXOFTSBSA-N"
"661","Q07817","BCL-xL","CRBN","","","CN(CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F)C(=O)CCCCCCN1C=C(COCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","179","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1515.211","1513.52875718","10.18","104","10","21","4","36","290.18","C73H87ClF3N11O13S3","InChI=1S/C73H87ClF3N11O13S3/c1-72(2)31-29-59(50-17-21-53(74)22-18-50)52(45-72)46-85-35-37-86(38-36-85)56-23-19-51(20-24-56)68(91)82-104(97,98)58-25-26-61(64(44-58)103(95,96)73(75,76)77)79-54(49-102-57-12-7-6-8-13-57)30-34-84(3)66(90)16-9-4-5-10-33-87-47-55(81-83-87)48-101-43-42-100-41-40-99-39-32-78-62-15-11-14-60-67(62)71(94)88(70(60)93)63-27-28-65(89)80-69(63)92/h6-8,11-15,17-26,44,47,54,63,78-79H,4-5,9-10,16,27-43,45-46,48-49H2,1-3H3,(H,82,91)(H,80,89,92)/t54-,63?/m1/s1","OAKXZIGOPMXDGW-WNIUGPFTSA-N"
"662","Q07817","BCL-xL","CRBN","","","CN(CCCCCCCN1C=C(COCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","6.3","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","29.2/62.2/61.7","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1457.175","1455.52327788","11.29","100","10","20","4","34","263.88","C71H85ClF3N11O11S3","InChI=1S/C71H85ClF3N11O11S3/c1-70(2)31-29-58(49-17-21-52(72)22-18-49)51(44-70)45-83-36-38-84(39-37-83)55-23-19-50(20-24-55)66(88)80-100(94,95)57-25-26-60(63(43-57)99(92,93)71(73,74)75)77-53(48-98-56-13-8-7-9-14-56)30-35-82(3)33-10-5-4-6-11-34-85-46-54(79-81-85)47-97-42-41-96-40-32-76-61-16-12-15-59-65(61)69(91)86(68(59)90)62-27-28-64(87)78-67(62)89/h7-9,12-26,43,46,53,62,76-77H,4-6,10-11,27-42,44-45,47-48H2,1-3H3,(H,80,88)(H,78,87,89)/t53-,62?/m1/s1","ZFKTXHMPLCYQMU-YOHLDDLQSA-N"
"663","Q07817","BCL-xL","CRBN","","","CN(CCCCCCCN1C=C(COCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1501.228","1499.54949263","11.14","103","10","21","4","37","273.11","C73H89ClF3N11O12S3","InChI=1S/C73H89ClF3N11O12S3/c1-72(2)31-29-60(51-17-21-54(74)22-18-51)53(46-72)47-85-36-38-86(39-37-85)57-23-19-52(20-24-57)68(90)82-103(96,97)59-25-26-62(65(45-59)102(94,95)73(75,76)77)79-55(50-101-58-13-8-7-9-14-58)30-35-84(3)33-10-5-4-6-11-34-87-48-56(81-83-87)49-100-44-43-99-42-41-98-40-32-78-63-16-12-15-61-67(63)71(93)88(70(61)92)64-27-28-66(89)80-69(64)91/h7-9,12-26,45,48,55,64,78-79H,4-6,10-11,27-44,46-47,49-50H2,1-3H3,(H,82,90)(H,80,89,91)/t55-,64?/m1/s1","ZIADKWWMMNTWBR-VJBWGSLXSA-N"
"664","Q07817","BCL-xL","CRBN","","","CN(CCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","10.6","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.5/129/70.2","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1231.883","1230.37555103","10.74","84","9","15","4","22","214.71","C60H66ClF3N8O9S3","InChI=1S/C60H66ClF3N8O9S3/c1-59(2)27-25-47(39-13-17-42(61)18-14-39)41(36-59)37-70-31-33-71(34-32-70)44-19-15-40(16-20-44)55(74)68-84(80,81)46-21-22-49(52(35-46)83(78,79)60(62,63)64)66-43(38-82-45-9-5-4-6-10-45)26-30-69(3)29-8-28-65-50-12-7-11-48-54(50)58(77)72(57(48)76)51-23-24-53(73)67-56(51)75/h4-7,9-22,35,43,51,65-66H,8,23-34,36-38H2,1-3H3,(H,68,74)(H,67,73,75)/t43-,51?/m1/s1","HUFMCQSCXIKKGP-KYNVYPTLSA-N"
"665","Q07817","BCL-xL","CRBN","","","CN(CCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","38.7","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1245.91","1244.3912011","11.1","85","9","15","4","23","214.71","C61H68ClF3N8O9S3","InChI=1S/C61H68ClF3N8O9S3/c1-60(2)28-26-48(40-14-18-43(62)19-15-40)42(37-60)38-71-32-34-72(35-33-71)45-20-16-41(17-21-45)56(75)69-85(81,82)47-22-23-50(53(36-47)84(79,80)61(63,64)65)67-44(39-83-46-10-5-4-6-11-46)27-31-70(3)30-8-7-29-66-51-13-9-12-49-55(51)59(78)73(58(49)77)52-24-25-54(74)68-57(52)76/h4-6,9-23,36,44,52,66-67H,7-8,24-35,37-39H2,1-3H3,(H,69,75)(H,68,74,76)/t44-,52?/m1/s1","SWYIOEPEGVTQNK-IAUHEVLUSA-N"
"666","Q07817","BCL-xL","CRBN","","","CN(CCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","60.9","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1259.937","1258.40685116","11.46","86","9","15","4","24","214.71","C62H70ClF3N8O9S3","InChI=1S/C62H70ClF3N8O9S3/c1-61(2)29-27-49(41-15-19-44(63)20-16-41)43(38-61)39-72-33-35-73(36-34-72)46-21-17-42(18-22-46)57(76)70-86(82,83)48-23-24-51(54(37-48)85(80,81)62(64,65)66)68-45(40-84-47-11-6-4-7-12-47)28-32-71(3)31-9-5-8-30-67-52-14-10-13-50-56(52)60(79)74(59(50)78)53-25-26-55(75)69-58(53)77/h4,6-7,10-24,37,45,53,67-68H,5,8-9,25-36,38-40H2,1-3H3,(H,70,76)(H,69,75,77)/t45-,53?/m1/s1","QFCDHMSALJXVSD-HVMLLUAGSA-N"
"667","Q07817","BCL-xL","CRBN","","","CN(CCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","147","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1273.964","1272.42250122","11.81","87","9","15","4","25","214.71","C63H72ClF3N8O9S3","InChI=1S/C63H72ClF3N8O9S3/c1-62(2)30-28-50(42-16-20-45(64)21-17-42)44(39-62)40-73-34-36-74(37-35-73)47-22-18-43(19-23-47)58(77)71-87(83,84)49-24-25-52(55(38-49)86(81,82)63(65,66)67)69-46(41-85-48-12-7-6-8-13-48)29-33-72(3)32-10-5-4-9-31-68-53-15-11-14-51-57(53)61(80)75(60(51)79)54-26-27-56(76)70-59(54)78/h6-8,11-25,38,46,54,68-69H,4-5,9-10,26-37,39-41H2,1-3H3,(H,71,77)(H,70,76,78)/t46-,54?/m1/s1","WBUJSZMOSBBKIF-MFJGLPAGSA-N"
"668","Q07817","BCL-xL","CRBN","","","CN(CCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">2000","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1302.018","1300.45380135","12.9","89","9","15","4","27","214.71","C65H76ClF3N8O9S3","InChI=1S/C65H76ClF3N8O9S3/c1-64(2)32-30-52(44-18-22-47(66)23-19-44)46(41-64)42-75-36-38-76(39-37-75)49-24-20-45(21-25-49)60(79)73-89(85,86)51-26-27-54(57(40-51)88(83,84)65(67,68)69)71-48(43-87-50-14-9-8-10-15-50)31-35-74(3)34-12-7-5-4-6-11-33-70-55-17-13-16-53-59(55)63(82)77(62(53)81)56-28-29-58(78)72-61(56)80/h8-10,13-27,40,48,56,70-71H,4-7,11-12,28-39,41-43H2,1-3H3,(H,73,79)(H,72,78,80)/t48-,56?/m1/s1","SUNRURYBVKWHBR-YJUSKGKKSA-N"
"669","Q07817","BCL-xL","CRBN","","","CN(CCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1305.962","1304.41233046","10.09","89","9","17","4","27","233.17","C63H72ClF3N8O11S3","InChI=1S/C63H72ClF3N8O11S3/c1-62(2)26-24-50(42-12-16-45(64)17-13-42)44(39-62)40-73-29-31-74(32-30-73)47-18-14-43(15-19-47)58(77)71-89(83,84)49-20-21-52(55(38-49)88(81,82)63(65,66)67)69-46(41-87-48-8-5-4-6-9-48)25-28-72(3)33-35-86-37-36-85-34-27-68-53-11-7-10-51-57(53)61(80)75(60(51)79)54-22-23-56(76)70-59(54)78/h4-21,38,46,54,68-69H,22-37,39-41H2,1-3H3,(H,71,77)(H,70,76,78)/t46-,54?/m1/s1","KIZIUIIALLXWBQ-MFJGLPAGSA-N"
"670","Q07817","BCL-xL","CRBN","","XZ739","CN(CCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","2.5","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1/41.8/25.3","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1350.015","1348.43854521","9.94","92","9","18","4","30","242.4","C65H76ClF3N8O12S3","InChI=1S/C65H76ClF3N8O12S3/c1-64(2)26-24-52(44-12-16-47(66)17-13-44)46(41-64)42-75-29-31-76(32-30-75)49-18-14-45(15-19-49)60(79)73-92(85,86)51-20-21-54(57(40-51)91(83,84)65(67,68)69)71-48(43-90-50-8-5-4-6-9-50)25-28-74(3)33-35-88-37-39-89-38-36-87-34-27-70-55-11-7-10-53-59(55)63(82)77(62(53)81)56-22-23-58(78)72-61(56)80/h4-21,40,48,56,70-71H,22-39,41-43H2,1-3H3,(H,73,79)(H,72,78,80)/t48-,56?/m1/s1","RTASGZOITGGVPZ-YJUSKGKKSA-N"
"671","Q07817","BCL-xL","CRBN","","","CN(CCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(S(=O)(=O)NC(=O)C2=CC=C(N3CCN(CC4=C(C5=CC=C(Cl)C=C5)CCC(C)(C)C4)CC3)C=C2)C=C1S(=O)(=O)C(F)(F)F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19.3","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1394.068","1392.46475996","9.8","95","9","19","4","33","251.63","C67H80ClF3N8O13S3","InChI=1S/C67H80ClF3N8O13S3/c1-66(2)26-24-54(46-12-16-49(68)17-13-46)48(43-66)44-77-29-31-78(32-30-77)51-18-14-47(15-19-51)62(81)75-95(87,88)53-20-21-56(59(42-53)94(85,86)67(69,70)71)73-50(45-93-52-8-5-4-6-9-52)25-28-76(3)33-35-90-37-39-92-41-40-91-38-36-89-34-27-72-57-11-7-10-55-61(57)65(84)79(64(55)83)58-22-23-60(80)74-63(58)82/h4-21,42,50,58,72-73H,22-41,43-45H2,1-3H3,(H,75,81)(H,74,80,82)/t50-,58?/m1/s1","YIYROHZVGRZRNT-XIMDYXIDSA-N"
"672","Q16678","CYP1B1","CRBN","","","COC1=CC=C(OC)C2=C1C(OC)=CC1=C2OC(C2=CC=C(C3=CN(CCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=CC1=O","","","","","","101.2","IC50 of CYP1B1 was determined by the standard EROD assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.112028","729.702","729.207092192","3.58","54","8","13","1","10","181.39","C39H31N5O10","InChI=1S/C39H31N5O10/c1-50-27-12-13-28(51-2)35-34(27)31(52-3)17-23-26(45)18-30(54-36(23)35)21-9-7-20(8-10-21)24-19-43(42-41-24)15-16-53-29-6-4-5-22-33(29)39(49)44(38(22)48)25-11-14-32(46)40-37(25)47/h4-10,12-13,17-19,25H,11,14-16H2,1-3H3,(H,40,46,47)","PCEJZZQEYHWWEA-UHFFFAOYSA-N"
"673","Q16678","CYP1B1","CRBN","","","COC1=CC=C(OC)C2=C1C(OC)=CC1=C2OC(C2=CC=C(C3=CN(CCCCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=CC1=O","","","","","","152.7","IC50 of CYP1B1 was determined by the standard EROD assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.112028","771.783","771.254042384","4.65","57","8","13","1","13","181.39","C42H37N5O10","InChI=1S/C42H37N5O10/c1-53-30-15-16-31(54-2)38-37(30)34(55-3)20-26-29(48)21-33(57-39(26)38)24-12-10-23(11-13-24)27-22-46(45-44-27)18-5-4-6-19-56-32-9-7-8-25-36(32)42(52)47(41(25)51)28-14-17-35(49)43-40(28)50/h7-13,15-16,20-22,28H,4-6,14,17-19H2,1-3H3,(H,43,49,50)","XNPATMUAJOWLGL-UHFFFAOYSA-N"
"674","Q16678","CYP1B1","CRBN","","","COC1=CC=C(OC)C2=C1C(OC)=CC1=C2OC(C2=CC=C(C3=CN(CCCCCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=CC1=O","","","","","","95.1","IC50 of CYP1B1 was determined by the standard EROD assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.112028","785.81","785.269692448","5.01","58","8","13","1","14","181.39","C43H39N5O10","InChI=1S/C43H39N5O10/c1-54-31-16-17-32(55-2)39-38(31)35(56-3)21-27-30(49)22-34(58-40(27)39)25-13-11-24(12-14-25)28-23-47(46-45-28)19-6-4-5-7-20-57-33-10-8-9-26-37(33)43(53)48(42(26)52)29-15-18-36(50)44-41(29)51/h8-14,16-17,21-23,29H,4-7,15,18-20H2,1-3H3,(H,44,50,51)","MRMQVUIZIOZVSD-UHFFFAOYSA-N"
"675","Q16678","CYP1B1","CRBN","","","COC1=CC=C(OC)C2=C1C(OC)=CC1=C2OC(C2=CC=C(C3=CN(CCCCCCCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=CC1=O","","","","","","166.2","IC50 of CYP1B1 was determined by the standard EROD assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.112028","813.864","813.300992576","6.09","60","8","13","1","16","181.39","C45H43N5O10","InChI=1S/C45H43N5O10/c1-56-33-18-19-34(57-2)41-40(33)37(58-3)23-29-32(51)24-36(60-42(29)41)27-15-13-26(14-16-27)30-25-49(48-47-30)21-8-6-4-5-7-9-22-59-35-12-10-11-28-39(35)45(55)50(44(28)54)31-17-20-38(52)46-43(31)53/h10-16,18-19,23-25,31H,4-9,17,20-22H2,1-3H3,(H,46,52,53)","STGUNPSWTPSQLZ-UHFFFAOYSA-N"
"676","P06730","eIF4E","CRBN","","","NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(=O)(O)NCCCCCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)[C@@H](O)[C@H]2O)C(=O)[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.080","717.633","717.227189602","-3.99","50","6","14","8","13","293.42","C29H36N9O11P","InChI=1S/C29H36N9O11P/c30-29-35-24-21(26(44)36-29)31-13-38(24)28-23(42)22(41)18(49-28)12-48-50(46,47)32-10-3-1-2-7-19(39)33-16-6-4-5-14-15(16)11-37(27(14)45)17-8-9-20(40)34-25(17)43/h4-6,13,17-18,22-23,28,41-42H,1-3,7-12H2,(H,33,39)(H2,32,46,47)(H,34,40,43)(H3,30,35,36,44)/t17?,18-,22-,23-,28-/m1/s1","GJWBHYKVCHKLAR-IIRGGMTPSA-N"
"677","P06730","eIF4E","CRBN","","","NC1=NC2=C(C(=O)[NH]1)[N+](CC1=CC=CC=C1)=CN2[C@@H]1O[C@H](COP(=O)(O)NCCCCCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)[C@@H](O)[C@H]1O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.080","808.766","808.281416246","-2.26","57","7","13","8","15","284.41","C36H43N9O11P+","InChI=1S/C36H42N9O11P/c37-36-41-31-28(33(51)42-36)43(16-20-8-3-1-4-9-20)19-45(31)35-30(49)29(48)25(56-35)18-55-57(53,54)38-15-6-2-5-12-26(46)39-23-11-7-10-21-22(23)17-44(34(21)52)24-13-14-27(47)40-32(24)50/h1,3-4,7-11,19,24-25,29-30,35,48-49H,2,5-6,12-18H2,(H6-,37,38,39,40,41,42,46,47,50,51,53,54)/p+1/t24?,25-,29-,30-,35-/m1/s1","OWTLEKVFFBLHIY-ZRULNDGESA-O"
"678","P06730","eIF4E","CRBN","","","NC1=NC2=C(C(=O)[NH]1)[N+](CC1=CC=C(F)C=C1)=CN2[C@@H]1O[C@H](COP(=O)(O)NCCCCCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)[C@@H](O)[C@H]1O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.080","826.756","826.271994434","-2.16","58","7","13","8","15","284.41","C36H42FN9O11P+","InChI=1S/C36H41FN9O11P/c37-20-10-8-19(9-11-20)15-44-18-46(31-28(44)33(52)43-36(38)42-31)35-30(50)29(49)25(57-35)17-56-58(54,55)39-14-3-1-2-7-26(47)40-23-6-4-5-21-22(23)16-45(34(21)53)24-12-13-27(48)41-32(24)51/h4-6,8-11,18,24-25,29-30,35,49-50H,1-3,7,12-17H2,(H6-,38,39,40,41,42,43,47,48,51,52,54,55)/p+1/t24?,25-,29-,30-,35-/m1/s1","QQSBSVMPMXMJAU-ZRULNDGESA-O"
"679","P06730","eIF4E","CRBN","","","NC1=NC2=C(N=CN2[C@@H]2O[C@H](COS(=O)(=O)NC(=O)CCC(=O)NCCCCCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)[C@@H](O)[C@H]2O)C(=O)[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2019.01.080","816.807","816.24970234","-4.35","57","6","17","8","16","336.43","C33H40N10O13S","InChI=1S/C33H40N10O13S/c34-33-39-28-25(30(51)40-33)36-15-43(28)32-27(49)26(48)20(56-32)14-55-57(53,54)41-24(47)11-10-21(44)35-12-3-1-2-7-22(45)37-18-6-4-5-16-17(18)13-42(31(16)52)19-8-9-23(46)38-29(19)50/h4-6,15,19-20,26-27,32,48-49H,1-3,7-14H2,(H,35,44)(H,37,45)(H,41,47)(H,38,46,50)(H3,34,39,40,51)/t19?,20-,26-,27-,32-/m1/s1","QBVWMCGANDDXFV-CRKLCICUSA-N"
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"694","P29373","CRABP-II","cIAP1","","","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/ja100691p","764.961","764.4360295","3.75","55","2","10","5","22","198.87","C42H60N4O9","InChI=1S/C42H60N4O9/c1-28(2)24-36(45-40(51)39(50)34(43)26-32-14-9-8-10-15-32)41(52)54-23-22-53-21-20-44-37(47)27-55-46-35-18-19-42(6,7)33(31(35)5)17-16-29(3)12-11-13-30(4)25-38(48)49/h8-17,25,28,34,36,39,50H,18-24,26-27,43H2,1-7H3,(H,44,47)(H,45,51)(H,48,49)/b13-11+,17-16+,29-12+,30-25+,46-35+/t34-,36+,39+/m1/s1","XEMRMMAFXLINDA-XVCXXHFGSA-N"
"695","P29762","CRABP-I","cIAP1","","","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOCCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/ja100691p","809.014","808.462244248","3.6","58","2","11","5","25","208.1","C44H64N4O10","InChI=1S/C44H64N4O10/c1-30(2)26-38(47-42(53)41(52)36(45)28-34-14-9-8-10-15-34)43(54)57-25-24-56-23-22-55-21-20-46-39(49)29-58-48-37-18-19-44(6,7)35(33(37)5)17-16-31(3)12-11-13-32(4)27-40(50)51/h8-17,27,30,36,38,41,52H,18-26,28-29,45H2,1-7H3,(H,46,49)(H,47,53)(H,50,51)/b13-11+,17-16+,31-12+,32-27+,48-37+/t36-,38+,41+/m1/s1","LJDTZKKSXVIAPQ-FATAJGLMSA-N"
"695","P29373","CRABP-II","cIAP1","","","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOCCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/ja100691p","809.014","808.462244248","3.6","58","2","11","5","25","208.1","C44H64N4O10","InChI=1S/C44H64N4O10/c1-30(2)26-38(47-42(53)41(52)36(45)28-34-14-9-8-10-15-34)43(54)57-25-24-56-23-22-55-21-20-46-39(49)29-58-48-37-18-19-44(6,7)35(33(37)5)17-16-31(3)12-11-13-32(4)27-40(50)51/h8-17,27,30,36,38,41,52H,18-26,28-29,45H2,1-7H3,(H,46,49)(H,47,53)(H,50,51)/b13-11+,17-16+,31-12+,32-27+,48-37+/t36-,38+,41+/m1/s1","LJDTZKKSXVIAPQ-FATAJGLMSA-N"
"696","P29762","CRABP-I","cIAP1","","","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOCCOCCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/ja100691p","853.067","852.488458996","3.45","61","2","12","5","28","217.33","C46H68N4O11","InChI=1S/C46H68N4O11/c1-32(2)28-40(49-44(55)43(54)38(47)30-36-14-9-8-10-15-36)45(56)60-27-26-59-25-24-58-23-22-57-21-20-48-41(51)31-61-50-39-18-19-46(6,7)37(35(39)5)17-16-33(3)12-11-13-34(4)29-42(52)53/h8-17,29,32,38,40,43,54H,18-28,30-31,47H2,1-7H3,(H,48,51)(H,49,55)(H,52,53)/b13-11+,17-16+,33-12+,34-29+,50-39+/t38-,40+,43+/m1/s1","RZIQIEBBFSSCIQ-KMRDRQGYSA-N"
"696","P29373","CRABP-II","cIAP1","","","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOCCOCCOC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/ja100691p","853.067","852.488458996","3.45","61","2","12","5","28","217.33","C46H68N4O11","InChI=1S/C46H68N4O11/c1-32(2)28-40(49-44(55)43(54)38(47)30-36-14-9-8-10-15-36)45(56)60-27-26-59-25-24-58-23-22-57-21-20-48-41(51)31-61-50-39-18-19-46(6,7)37(35(39)5)17-16-33(3)12-11-13-34(4)29-42(52)53/h8-17,29,32,38,40,43,54H,18-28,30-31,47H2,1-7H3,(H,48,51)(H,49,55)(H,52,53)/b13-11+,17-16+,33-12+,34-29+,50-39+/t38-,40+,43+/m1/s1","RZIQIEBBFSSCIQ-KMRDRQGYSA-N"
"697","Q07817","BCL-xL","VHL","","DT2216","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","53","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","77.1/213/278","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112186","1542.39","1540.58343561","12.83","105","10","17","5","28","251.07","C77H96ClF3N10O10S4","InChI=1S/C77H96ClF3N10O10S4/c1-51(53-18-20-55(21-19-53)70-52(2)82-50-103-70)83-73(96)66-44-61(92)48-91(66)74(97)71(75(3,4)5)85-68(93)16-12-9-13-17-69(94)90-42-36-87(37-43-90)35-33-59(49-102-62-14-10-8-11-15-62)84-65-31-30-63(45-67(65)104(98,99)77(79,80)81)105(100,101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6,7)34-32-64(57)54-22-26-58(78)27-23-54/h8,10-11,14-15,18-31,45,50-51,59,61,66,71,84,92H,9,12-13,16-17,32-44,46-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1","PXVFFBGSTYQHRO-REQIQPEASA-N"
"697","Q07817","BCL-xL","VHL","","DT2216","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)C(C)(C)C)C=C2)SC=N1","63/>3000","90.8/26","Degradation of BCL-xL in MOLT-4/platelets cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","52/23/160","Inhibit viability of MOLT-4/RS4;11/H146 cells","","","","","","","","","","","","","10.1038/s41591-019-0668-z","1542.39","1540.58343561","12.83","105","10","17","5","28","251.07","C77H96ClF3N10O10S4","InChI=1S/C77H96ClF3N10O10S4/c1-51(53-18-20-55(21-19-53)70-52(2)82-50-103-70)83-73(96)66-44-61(92)48-91(66)74(97)71(75(3,4)5)85-68(93)16-12-9-13-17-69(94)90-42-36-87(37-43-90)35-33-59(49-102-62-14-10-8-11-15-62)84-65-31-30-63(45-67(65)104(98,99)77(79,80)81)105(100,101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6,7)34-32-64(57)54-22-26-58(78)27-23-54/h8,10-11,14-15,18-31,45,50-51,59,61,66,71,84,92H,9,12-13,16-17,32-44,46-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1","PXVFFBGSTYQHRO-REQIQPEASA-N"
"698","P11802","CDK4","CRBN","","BSJ-03-008","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","77","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","859.989","859.412943036","3.49","63","8","15","4","16","220.93","C45H53N11O7","InChI=1S/C45H53N11O7/c1-27-32-25-49-45(52-40(32)55(29-10-5-6-11-29)43(62)38(27)28(2)57)50-35-16-14-30(24-48-35)54-22-20-53(21-23-54)26-37(59)47-19-8-4-3-7-18-46-33-13-9-12-31-39(33)44(63)56(42(31)61)34-15-17-36(58)51-41(34)60/h9,12-14,16,24-25,29,34,46H,3-8,10-11,15,17-23,26H2,1-2H3,(H,47,59)(H,51,58,60)(H,48,49,50,52)","ANSURJFIEUQFSD-UHFFFAOYSA-N"
"698","Q00534","CDK6","CRBN","","BSJ-03-008","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","27.6","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","859.989","859.412943036","3.49","63","8","15","4","16","220.93","C45H53N11O7","InChI=1S/C45H53N11O7/c1-27-32-25-49-45(52-40(32)55(29-10-5-6-11-29)43(62)38(27)28(2)57)50-35-16-14-30(24-48-35)54-22-20-53(21-23-54)26-37(59)47-19-8-4-3-7-18-46-33-13-9-12-31-39(33)44(63)56(42(31)61)34-15-17-36(58)51-41(34)60/h9,12-14,16,24-25,29,34,46H,3-8,10-11,15,17-23,26H2,1-2H3,(H,47,59)(H,51,58,60)(H,48,49,50,52)","ANSURJFIEUQFSD-UHFFFAOYSA-N"
"699","P11802","CDK4","CRBN","","BSJ-03-009","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","1024.146","1023.48141652","1.32","74","8","20","4","27","267.08","C51H65N11O12","InChI=1S/C51H65N11O12/c1-33-38-31-55-51(58-46(38)61(35-6-3-4-7-35)49(68)44(33)34(2)63)56-41-12-10-36(30-54-41)60-18-16-59(17-19-60)32-43(65)53-15-21-71-23-25-73-27-29-74-28-26-72-24-22-70-20-14-52-39-9-5-8-37-45(39)50(69)62(48(37)67)40-11-13-42(64)57-47(40)66/h5,8-10,12,30-31,35,40,52H,3-4,6-7,11,13-29,32H2,1-2H3,(H,53,65)(H,57,64,66)(H,54,55,56,58)","KWLAGOJMQISZMM-UHFFFAOYSA-N"
"699","Q00534","CDK6","CRBN","","BSJ-03-009","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","1024.146","1023.48141652","1.32","74","8","20","4","27","267.08","C51H65N11O12","InChI=1S/C51H65N11O12/c1-33-38-31-55-51(58-46(38)61(35-6-3-4-7-35)49(68)44(33)34(2)63)56-41-12-10-36(30-54-41)60-18-16-59(17-19-60)32-43(65)53-15-21-71-23-25-73-27-29-74-28-26-72-24-22-70-20-14-52-39-9-5-8-37-45(39)50(69)62(48(37)67)40-11-13-42(64)57-47(40)66/h5,8-10,12,30-31,35,40,52H,3-4,6-7,11,13-29,32H2,1-2H3,(H,53,65)(H,57,64,66)(H,54,55,56,58)","KWLAGOJMQISZMM-UHFFFAOYSA-N"
"700","P11802","CDK4","CRBN","","AC-1-277","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","860.973","860.396958624","2.93","63","8","15","3","16","218.13","C45H52N10O8","InChI=1S/C45H52N10O8/c1-27-32-25-48-45(51-40(32)54(29-10-5-6-11-29)43(61)38(27)28(2)56)49-35-16-14-30(24-47-35)53-22-20-52(21-23-53)19-8-4-3-7-18-46-37(58)26-63-34-13-9-12-31-39(34)44(62)55(42(31)60)33-15-17-36(57)50-41(33)59/h9,12-14,16,24-25,29,33H,3-8,10-11,15,17-23,26H2,1-2H3,(H,46,58)(H,50,57,59)(H,47,48,49,51)","IPLIKDPWOGNBJJ-UHFFFAOYSA-N"
"700","Q00534","CDK6","CRBN","","AC-1-277","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","860.973","860.396958624","2.93","63","8","15","3","16","218.13","C45H52N10O8","InChI=1S/C45H52N10O8/c1-27-32-25-48-45(51-40(32)54(29-10-5-6-11-29)43(61)38(27)28(2)56)49-35-16-14-30(24-47-35)53-22-20-52(21-23-53)19-8-4-3-7-18-46-37(58)26-63-34-13-9-12-31-39(34)44(62)55(42(31)60)33-15-17-36(57)50-41(33)59/h9,12-14,16,24-25,29,33H,3-8,10-11,15,17-23,26H2,1-2H3,(H,46,58)(H,50,57,59)(H,47,48,49,51)","IPLIKDPWOGNBJJ-UHFFFAOYSA-N"
"701","P11802","CDK4","CRBN","","BSJ-02-162","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","10","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","3","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50)","AWPNCYPNCSCZFL-UHFFFAOYSA-N"
"701","P11802","CDK4","CRBN","","BSJ-02-162","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","25.7","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50)","AWPNCYPNCSCZFL-UHFFFAOYSA-N"
"701","Q00534","CDK6","CRBN","","BSJ-02-162","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","7.57","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50)","AWPNCYPNCSCZFL-UHFFFAOYSA-N"
"701","P30291","Wee1","CRBN","","BSJ-02-162","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50)","AWPNCYPNCSCZFL-UHFFFAOYSA-N"
"701","Q00534","CDK6","CRBN","","BSJ-02-162","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","0.8","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","8","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","831.935","831.381642908","2.78","61","8","15","4","14","220.93","C43H49N11O7","InChI=1S/C43H49N11O7/c1-25-30-23-47-43(50-38(30)53(27-8-3-4-9-27)41(60)36(25)26(2)55)48-33-14-12-28(22-46-33)52-20-18-51(19-21-52)17-6-5-16-44-35(57)24-45-31-11-7-10-29-37(31)42(61)54(40(29)59)32-13-15-34(56)49-39(32)58/h7,10-12,14,22-23,27,32,45H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,57)(H,49,56,58)(H,46,47,48,50)","AWPNCYPNCSCZFL-UHFFFAOYSA-N"
"702","P11802","CDK4","CRBN","","BSJ-03-204","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","26.9","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","832.919","832.365658496","2.21","61","8","15","3","14","218.13","C43H48N10O8","InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49)","KDMOCOWXLQOXEB-UHFFFAOYSA-N"
"702","Q00534","CDK6","CRBN","","BSJ-03-204","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","10.4","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","832.919","832.365658496","2.21","61","8","15","3","14","218.13","C43H48N10O8","InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49)","KDMOCOWXLQOXEB-UHFFFAOYSA-N"
"702","P30291","Wee1","CRBN","","BSJ-03-204","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","832.919","832.365658496","2.21","61","8","15","3","14","218.13","C43H48N10O8","InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49)","KDMOCOWXLQOXEB-UHFFFAOYSA-N"
"702","Q15118","PDK1","CRBN","","BSJ-03-204","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","832.919","832.365658496","2.21","61","8","15","3","14","218.13","C43H48N10O8","InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49)","KDMOCOWXLQOXEB-UHFFFAOYSA-N"
"703","P11802","CDK4","CRBN","","BSJ-03-135","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","818.892","818.350008432","1.85","60","8","15","3","13","218.13","C42H46N10O8","InChI=1S/C42H46N10O8/c1-24-29-22-45-42(48-37(29)51(26-7-3-4-8-26)40(58)35(24)25(2)53)46-32-13-11-27(21-44-32)50-19-17-49(18-20-50)16-6-15-43-34(55)23-60-31-10-5-9-28-36(31)41(59)52(39(28)57)30-12-14-33(54)47-38(30)56/h5,9-11,13,21-22,26,30H,3-4,6-8,12,14-20,23H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","JKKQZAPFDPNDOE-UHFFFAOYSA-N"
"703","Q00534","CDK6","CRBN","","BSJ-03-135","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","818.892","818.350008432","1.85","60","8","15","3","13","218.13","C42H46N10O8","InChI=1S/C42H46N10O8/c1-24-29-22-45-42(48-37(29)51(26-7-3-4-8-26)40(58)35(24)25(2)53)46-32-13-11-27(21-44-32)50-19-17-49(18-20-50)16-6-15-43-34(55)23-60-31-10-5-9-28-36(31)41(59)52(39(28)57)30-12-14-33(54)47-38(30)56/h5,9-11,13,21-22,26,30H,3-4,6-8,12,14-20,23H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","JKKQZAPFDPNDOE-UHFFFAOYSA-N"
"704","P11802","CDK4","CRBN","","AC-1-212","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","51","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","804.865","804.334358368","1.5","59","8","15","3","12","218.13","C41H44N10O8","InChI=1S/C41H44N10O8/c1-23-28-21-44-41(47-36(28)50(25-6-3-4-7-25)39(57)34(23)24(2)52)45-31-12-10-26(20-43-31)49-18-16-48(17-19-49)15-14-42-33(54)22-59-30-9-5-8-27-35(30)40(58)51(38(27)56)29-11-13-32(53)46-37(29)55/h5,8-10,12,20-21,25,29H,3-4,6-7,11,13-19,22H2,1-2H3,(H,42,54)(H,46,53,55)(H,43,44,45,47)","LIFBUOCXOCIEST-UHFFFAOYSA-N"
"704","P11802","CDK4","CRBN","","AC-1-212","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","69.6","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","804.865","804.334358368","1.5","59","8","15","3","12","218.13","C41H44N10O8","InChI=1S/C41H44N10O8/c1-23-28-21-44-41(47-36(28)50(25-6-3-4-7-25)39(57)34(23)24(2)52)45-31-12-10-26(20-43-31)49-18-16-48(17-19-49)15-14-42-33(54)22-59-30-9-5-8-27-35(30)40(58)51(38(27)56)29-11-13-32(53)46-37(29)55/h5,8-10,12,20-21,25,29H,3-4,6-7,11,13-19,22H2,1-2H3,(H,42,54)(H,46,53,55)(H,43,44,45,47)","LIFBUOCXOCIEST-UHFFFAOYSA-N"
"704","Q00534","CDK6","CRBN","","AC-1-212","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","51","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","804.865","804.334358368","1.5","59","8","15","3","12","218.13","C41H44N10O8","InChI=1S/C41H44N10O8/c1-23-28-21-44-41(47-36(28)50(25-6-3-4-7-25)39(57)34(23)24(2)52)45-31-12-10-26(20-43-31)49-18-16-48(17-19-49)15-14-42-33(54)22-59-30-9-5-8-27-35(30)40(58)51(38(27)56)29-11-13-32(53)46-37(29)55/h5,8-10,12,20-21,25,29H,3-4,6-7,11,13-19,22H2,1-2H3,(H,42,54)(H,46,53,55)(H,43,44,45,47)","LIFBUOCXOCIEST-UHFFFAOYSA-N"
"704","Q00534","CDK6","CRBN","","AC-1-212","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","34.6","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","804.865","804.334358368","1.5","59","8","15","3","12","218.13","C41H44N10O8","InChI=1S/C41H44N10O8/c1-23-28-21-44-41(47-36(28)50(25-6-3-4-7-25)39(57)34(23)24(2)52)45-31-12-10-26(20-43-31)49-18-16-48(17-19-49)15-14-42-33(54)22-59-30-9-5-8-27-35(30)40(58)51(38(27)56)29-11-13-32(53)46-37(29)55/h5,8-10,12,20-21,25,29H,3-4,6-7,11,13-19,22H2,1-2H3,(H,42,54)(H,46,53,55)(H,43,44,45,47)","LIFBUOCXOCIEST-UHFFFAOYSA-N"
"705","P11802","CDK4","CRBN","","BSJ-04-060","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","130","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","703.76","703.286679904","2.27","52","8","13","2","7","179.8","C37H37N9O6","InChI=1S/C37H37N9O6/c1-20-25-19-39-37(42-32(25)45(22-6-3-4-7-22)35(51)30(20)21(2)47)40-28-12-10-23(18-38-28)43-14-16-44(17-15-43)26-9-5-8-24-31(26)36(52)46(34(24)50)27-11-13-29(48)41-33(27)49/h5,8-10,12,18-19,22,27H,3-4,6-7,11,13-17H2,1-2H3,(H,41,48,49)(H,38,39,40,42)","HABSMJUGKHFHAY-UHFFFAOYSA-N"
"705","Q00534","CDK6","CRBN","","BSJ-04-060","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","45.1","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","703.76","703.286679904","2.27","52","8","13","2","7","179.8","C37H37N9O6","InChI=1S/C37H37N9O6/c1-20-25-19-39-37(42-32(25)45(22-6-3-4-7-22)35(51)30(20)21(2)47)40-28-12-10-23(18-38-28)43-14-16-44(17-15-43)26-9-5-8-24-31(26)36(52)46(34(24)50)27-11-13-29(48)41-33(27)49/h5,8-10,12,18-19,22,27H,3-4,6-7,11,13-17H2,1-2H3,(H,41,48,49)(H,38,39,40,42)","HABSMJUGKHFHAY-UHFFFAOYSA-N"
"706","P11802","CDK4","CRBN","","BSJ-01-151","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","175","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","821.94","821.397292972","2.79","60","8","15","3","16","196.46","C42H51N11O7","InChI=1S/C42H51N11O7/c1-49(2)40(57)33-24-27-25-45-42(48-37(27)52(33)28-6-3-4-7-28)46-34-12-10-29(26-44-34)51-17-15-50(16-18-51)19-21-60-23-22-59-20-14-43-31-9-5-8-30-36(31)41(58)53(39(30)56)32-11-13-35(54)47-38(32)55/h5,8-10,12,24-26,28,32,43H,3-4,6-7,11,13-23H2,1-2H3,(H,47,54,55)(H,44,45,46,48)","BOUANTLARJCBLR-UHFFFAOYSA-N"
"706","Q00534","CDK6","CRBN","","BSJ-01-151","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","142","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","821.94","821.397292972","2.79","60","8","15","3","16","196.46","C42H51N11O7","InChI=1S/C42H51N11O7/c1-49(2)40(57)33-24-27-25-45-42(48-37(27)52(33)28-6-3-4-7-28)46-34-12-10-29(26-44-34)51-17-15-50(16-18-51)19-21-60-23-22-59-20-14-43-31-9-5-8-30-36(31)41(58)53(39(30)56)32-11-13-35(54)47-38(32)55/h5,8-10,12,24-26,28,32,43H,3-4,6-7,11,13-23H2,1-2H3,(H,47,54,55)(H,44,45,46,48)","BOUANTLARJCBLR-UHFFFAOYSA-N"
"707","P11802","CDK4","CRBN","","BSJ-01-152","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","79.7","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","761.888","761.376163604","3.8","56","8","13","3","12","178.0","C40H47N11O5","InChI=1S/C40H47N11O5/c1-47(2)38(55)31-22-25-23-43-40(46-35(25)50(31)26-8-3-4-9-26)44-32-14-12-27(24-42-32)49-20-18-48(19-21-49)17-6-5-16-41-29-11-7-10-28-34(29)39(56)51(37(28)54)30-13-15-33(52)45-36(30)53/h7,10-12,14,22-24,26,30,41H,3-6,8-9,13,15-21H2,1-2H3,(H,45,52,53)(H,42,43,44,46)","GKLJPAJWLPATRA-UHFFFAOYSA-N"
"707","Q00534","CDK6","CRBN","","BSJ-01-152","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","65.5","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","761.888","761.376163604","3.8","56","8","13","3","12","178.0","C40H47N11O5","InChI=1S/C40H47N11O5/c1-47(2)38(55)31-22-25-23-43-40(46-35(25)50(31)26-8-3-4-9-26)44-32-14-12-27(24-42-32)49-20-18-48(19-21-49)17-6-5-16-41-29-11-7-10-28-34(29)39(56)51(37(28)54)30-13-15-33(52)45-36(30)53/h7,10-12,14,22-24,26,30,41H,3-6,8-9,13,15-21H2,1-2H3,(H,45,52,53)(H,42,43,44,46)","GKLJPAJWLPATRA-UHFFFAOYSA-N"
"708","P11802","CDK4","CRBN","","BSJ-01-187","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","70.8","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","818.94","818.39762732","3.15","60","8","14","4","14","207.1","C42H50N12O6","InChI=1S/C42H50N12O6/c1-50(2)40(59)32-22-26-23-46-42(49-37(26)53(32)27-8-3-4-9-27)47-33-14-12-28(24-45-33)52-20-18-51(19-21-52)17-6-5-16-43-35(56)25-44-30-11-7-10-29-36(30)41(60)54(39(29)58)31-13-15-34(55)48-38(31)57/h7,10-12,14,22-24,27,31,44H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,56)(H,48,55,57)(H,45,46,47,49)","INYCIZGIGUZUIJ-UHFFFAOYSA-N"
"708","Q00534","CDK6","CRBN","","BSJ-01-187","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","52.2","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","818.94","818.39762732","3.15","60","8","14","4","14","207.1","C42H50N12O6","InChI=1S/C42H50N12O6/c1-50(2)40(59)32-22-26-23-46-42(49-37(26)53(32)27-8-3-4-9-27)47-33-14-12-28(24-45-33)52-20-18-51(19-21-52)17-6-5-16-43-35(56)25-44-30-11-7-10-29-36(30)41(60)54(39(29)58)31-13-15-34(55)48-38(31)57/h7,10-12,14,22-24,27,31,44H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,56)(H,48,55,57)(H,45,46,47,49)","INYCIZGIGUZUIJ-UHFFFAOYSA-N"
"709","P11802","CDK4","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","50.6","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","O14874","BCKDK","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","Q00534","CDK6","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","Q15118","PDK1","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","Q15119","PDK2","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","Q15120","PDK3","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"709","Q8NI60","COQ8A","CRBN","","BSJ-04-132","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","819.924","819.381642908","2.58","60","8","14","3","14","204.3","C42H49N11O7","InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48)","GWLSXEHHNOBFOI-UHFFFAOYSA-N"
"710","P11802","CDK4","CRBN","","BSJ-01-158","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","8.26","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","805.891","805.36240536","4.62","59","8","13","3","13","170.58","C42H45F2N11O4","InChI=1S/C42H45F2N11O4/c1-24(2)54-25(3)48-38-29(43)19-27(20-33(38)54)37-30(44)22-47-42(51-37)49-34-11-9-26(21-46-34)23-53-17-15-52(16-18-53)14-5-4-13-45-31-8-6-7-28-36(31)41(59)55(40(28)58)32-10-12-35(56)50-39(32)57/h6-9,11,19-22,24,32,45H,4-5,10,12-18,23H2,1-3H3,(H,50,56,57)(H,46,47,49,51)","CMMLXWLDSJHQIT-UHFFFAOYSA-N"
"710","Q00534","CDK6","CRBN","","BSJ-01-158","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","13.1","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","805.891","805.36240536","4.62","59","8","13","3","13","170.58","C42H45F2N11O4","InChI=1S/C42H45F2N11O4/c1-24(2)54-25(3)48-38-29(43)19-27(20-33(38)54)37-30(44)22-47-42(51-37)49-34-11-9-26(21-46-34)23-53-17-15-52(16-18-53)14-5-4-13-45-31-8-6-7-28-36(31)41(59)55(40(28)58)32-10-12-35(56)50-39(32)57/h6-9,11,19-22,24,32,45H,4-5,10,12-18,23H2,1-3H3,(H,50,56,57)(H,46,47,49,51)","CMMLXWLDSJHQIT-UHFFFAOYSA-N"
"711","P11802","CDK4","CRBN","","BSJ-01-184","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCCCNC(=O)CNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","8.61","IC50 of CDK4/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","862.943","862.383869076","3.96","63","8","14","4","15","199.68","C44H48F2N12O5","InChI=1S/C44H48F2N12O5/c1-25(2)57-26(3)51-40-30(45)19-28(20-34(40)57)39-31(46)22-50-44(54-39)52-35-11-9-27(21-49-35)24-56-17-15-55(16-18-56)14-5-4-13-47-37(60)23-48-32-8-6-7-29-38(32)43(63)58(42(29)62)33-10-12-36(59)53-41(33)61/h6-9,11,19-22,25,33,48H,4-5,10,12-18,23-24H2,1-3H3,(H,47,60)(H,53,59,61)(H,49,50,52,54)","DUWSRWBWNVKYHS-UHFFFAOYSA-N"
"711","Q00534","CDK6","CRBN","","BSJ-01-184","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCCCNC(=O)CNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","12.5","IC50 of CDK6/D1 was obtained with Adapta activity assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","862.943","862.383869076","3.96","63","8","14","4","15","199.68","C44H48F2N12O5","InChI=1S/C44H48F2N12O5/c1-25(2)57-26(3)51-40-30(45)19-28(20-34(40)57)39-31(46)22-50-44(54-39)52-35-11-9-27(21-49-35)24-56-17-15-55(16-18-56)14-5-4-13-47-37(60)23-48-32-8-6-7-29-38(32)43(63)58(42(29)62)33-10-12-36(59)53-41(33)61/h6-9,11,19-22,25,33,48H,4-5,10,12-18,23-24H2,1-3H3,(H,47,60)(H,53,59,61)(H,49,50,52,54)","DUWSRWBWNVKYHS-UHFFFAOYSA-N"
"711","P50750","CDK9","CRBN","","BSJ-01-184","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCCCNC(=O)CNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201901336","862.943","862.383869076","3.96","63","8","14","4","15","199.68","C44H48F2N12O5","InChI=1S/C44H48F2N12O5/c1-25(2)57-26(3)51-40-30(45)19-28(20-34(40)57)39-31(46)22-50-44(54-39)52-35-11-9-27(21-49-35)24-56-17-15-55(16-18-56)14-5-4-13-47-37(60)23-48-32-8-6-7-29-38(32)43(63)58(42(29)62)33-10-12-36(59)53-41(33)61/h6-9,11,19-22,25,33,48H,4-5,10,12-18,23-24H2,1-3H3,(H,47,60)(H,53,59,61)(H,49,50,52,54)","DUWSRWBWNVKYHS-UHFFFAOYSA-N"
"712","O43924","PDEdelta","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCNC(=O)C4=CC=C(CN(CC5CCNCC5)S(=O)(=O)C5=CC=C(S(=O)(=O)N(CC6=CC=C(Cl)C=C6)C6CCCC6)C=C5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","14.8","Kd was determined by competitive fluorescent polarization analysis","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.6","Kd between CRBN and the complex of protac and PDEdelta was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201913904","1046.666","1045.34807542","4.84","72","8","13","4","23","229.93","C51H60ClN7O11S2","InChI=1S/C51H60ClN7O11S2/c52-39-14-10-36(11-15-39)34-58(40-4-1-2-5-40)72(67,68)42-18-16-41(17-19-42)71(65,66)57(33-37-22-24-53-25-23-37)32-35-8-12-38(13-9-35)48(61)55-27-29-70-31-30-69-28-26-54-44-7-3-6-43-47(44)51(64)59(50(43)63)45-20-21-46(60)56-49(45)62/h3,6-19,37,40,45,53-54H,1-2,4-5,20-34H2,(H,55,61)(H,56,60,62)","ODNPUYNXAYVCMJ-UHFFFAOYSA-N"
"713","O43924","PDEdelta","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCNC(=O)C4=CC=C(CN(CC5CCNCC5)S(=O)(=O)C5=CC=C(S(=O)(=O)N(CC6=CC=C(Cl)C=C6)C6CCCC6)C=C5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","27","Kd was determined by competitive fluorescent polarization analysis","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.4","Kd between CRBN and the complex of protac and PDEdelta was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201913904","1090.719","1089.37429017","4.69","75","8","14","4","26","239.16","C53H64ClN7O12S2","InChI=1S/C53H64ClN7O12S2/c54-41-14-10-38(11-15-41)36-60(42-4-1-2-5-42)75(69,70)44-18-16-43(17-19-44)74(67,68)59(35-39-22-24-55-25-23-39)34-37-8-12-40(13-9-37)50(63)57-27-29-72-31-33-73-32-30-71-28-26-56-46-7-3-6-45-49(46)53(66)61(52(45)65)47-20-21-48(62)58-51(47)64/h3,6-19,39,42,47,55-56H,1-2,4-5,20-36H2,(H,57,63)(H,58,62,64)","UULZKSRMNNXZEP-UHFFFAOYSA-N"
"714","O43924","PDEdelta","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCNC(=O)C4=CC=C(CN(CC5CCNCC5)S(=O)(=O)C5=CC=C(S(=O)(=O)N(CC6=CC=C(Cl)C=C6)C6CCCC6)C=C5)C=C4)=C3C2=O)C(=O)N1","48","83.4","Degradation of PDEdelta in Panc Tu-I cells after 24 h treatment","","","","","","","64.3","Kd was determined by competitive fluorescent polarization analysis","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","92.9","Kd between CRBN and the complex of protac and PDEdelta was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201913904","1134.772","1133.40050492","4.54","78","8","15","4","29","248.39","C55H68ClN7O13S2","InChI=1S/C55H68ClN7O13S2/c56-43-14-10-40(11-15-43)38-62(44-4-1-2-5-44)78(71,72)46-18-16-45(17-19-46)77(69,70)61(37-41-22-24-57-25-23-41)36-39-8-12-42(13-9-39)52(65)59-27-29-74-31-33-76-35-34-75-32-30-73-28-26-58-48-7-3-6-47-51(48)55(68)63(54(47)67)49-20-21-50(64)60-53(49)66/h3,6-19,41,44,49,57-58H,1-2,4-5,20-38H2,(H,59,65)(H,60,64,66)","OWYXKRGXEAHYMU-UHFFFAOYSA-N"
"715","O43924","PDEdelta","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C3=CC=C(CN(CC4CCNCC4)S(=O)(=O)C4=CC=C(S(=O)(=O)N(CC5=CC=C(Cl)C=C5)C5CCCC5)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","57.1","Kd was determined by competitive fluorescent polarization analysis","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201913904","1306.081","1304.50867546","6.22","89","8","16","5","32","264.44","C64H85ClN8O13S3","InChI=1S/C64H85ClN8O13S3/c1-45-59(87-44-69-45)50-15-9-46(10-16-50)38-68-62(77)57-37-54(74)42-72(57)63(78)60(64(2,3)4)70-58(75)43-86-36-35-85-34-33-84-32-31-83-30-29-67-61(76)51-17-11-47(12-18-51)39-71(40-49-25-27-66-28-26-49)88(79,80)55-21-23-56(24-22-55)89(81,82)73(53-7-5-6-8-53)41-48-13-19-52(65)20-14-48/h9-24,44,49,53-54,57,60,66,74H,5-8,25-43H2,1-4H3,(H,67,76)(H,68,77)(H,70,75)/t54-,57+,60-/m1/s1","XLFINVCISOPDEJ-RYSDOAKFSA-N"
"716","Q07817","BCL-xL","CRBN","","XZ906","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCC4=CN(CCCC(=O)N5CCN(CC#CC6=CC=C(OCCCC7=C(C(=O)O)N=C(N8CCC9=CC=CC(C(=O)NC%10=NC%11=CC=CC=C%11S%10)=C9C8)S7)C(F)=C6)CC5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","123","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","10.1039/c9cc07217a","1265.417","1264.42703574","3.58","90","11","21","4","27","282.18","C63H65FN12O12S2","InChI=1S/C63H65FN12O12S2/c64-46-36-40(17-19-50(46)88-30-7-15-52-56(61(83)84)68-63(90-52)74-25-21-41-9-3-10-43(45(41)38-74)57(79)69-62-66-47-12-1-2-14-51(47)89-62)8-5-23-72-26-28-73(29-27-72)54(78)16-6-24-75-37-42(70-71-75)39-87-35-34-86-33-32-85-31-22-65-48-13-4-11-44-55(48)60(82)76(59(44)81)49-18-20-53(77)67-58(49)80/h1-4,9-14,17,19,36-37,49,65H,6-7,15-16,18,20-35,38-39H2,(H,83,84)(H,66,69,79)(H,67,77,80)","FVEZBIHJSCGHJQ-UHFFFAOYSA-N"
"717","Q07817","BCL-xL","CRBN","","XZ424","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCC4=CN(CCCC(=O)N5CCN(CC#CC6=CC=C(OCCCC7=C(C(=O)O)N=C(N8CCC9=CC=CC(C(=O)NC%10=NC%11=CC=CC=C%11S%10)=C9C8)S7)C(F)=C6)CC5)N=N4)=C3C2=O)C(=O)N1","50","","Degradation of BCL-xL in MOLT-4 cells after 16 h treatment","","","","","","","","","0.009","Ki was determined by AlphaScreen competitive binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","51","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","10.1039/c9cc07217a","1221.364","1220.40082099","3.73","87","11","20","4","24","272.95","C61H61FN12O11S2","InChI=1S/C61H61FN12O11S2/c62-44-34-38(17-19-48(44)85-30-7-15-50-54(59(81)82)66-61(87-50)72-25-21-39-9-3-10-41(43(39)36-72)55(77)67-60-64-45-12-1-2-14-49(45)86-60)8-5-23-70-26-28-71(29-27-70)52(76)16-6-24-73-35-40(68-69-73)37-84-33-32-83-31-22-63-46-13-4-11-42-53(46)58(80)74(57(42)79)47-18-20-51(75)65-56(47)78/h1-4,9-14,17,19,34-35,47,63H,6-7,15-16,18,20-33,36-37H2,(H,81,82)(H,64,67,77)(H,65,75,78)","KDSYVLYKZZKENZ-UHFFFAOYSA-N"
"718","Q07817","BCL-xL","CRBN","","XZ418","O=C1CCC(N2CC3=C(NC(=O)COCCOCCOCC4=CN(CCCC(=O)N5CCN(CC#CC6=CC=C(OCCCC7=C(C(=O)O)N=C(N8CCC9=CC=CC(C(=O)NC%10=NC%11=CC=CC=C%11S%10)=C9C8)S7)C(F)=C6)CC5)N=N4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","140","Inhibit viability of MOLT-4 cells","","","","","","","","","","","","","10.1039/c9cc07217a","1265.417","1264.42703574","2.3","90","11","20","4","26","282.18","C63H65FN12O12S2","InChI=1S/C63H65FN12O12S2/c64-47-34-40(17-19-51(47)88-29-7-15-53-57(61(83)84)68-63(90-53)74-24-21-41-9-3-10-43(45(41)36-74)58(80)69-62-66-49-12-1-2-14-52(49)89-62)8-5-22-72-25-27-73(28-26-72)56(79)16-6-23-75-35-42(70-71-75)38-86-32-30-85-31-33-87-39-55(78)65-48-13-4-11-44-46(48)37-76(60(44)82)50-18-20-54(77)67-59(50)81/h1-4,9-14,17,19,34-35,50H,6-7,15-16,18,20-33,36-39H2,(H,65,78)(H,83,84)(H,66,69,80)(H,67,77,81)","YUWKVQVRTJFDQA-UHFFFAOYSA-N"
"719","P11802","CDK4","CRBN","","pal-pom","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","12.9","","Degradation of CDK4 in MDA-MB-231 cells after 18 h treatment","","","","","","","900","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","897.998","897.403440972","2.14","66","9","17","3","15","239.61","C46H51N13O7","InChI=1S/C46H51N13O7/c1-27-33-24-48-46(52-41(33)58(30-9-5-6-10-30)44(65)39(27)28(2)60)50-36-16-14-31(23-47-36)56-21-19-55(20-22-56)25-29-26-57(54-53-29)18-7-3-4-13-37(61)49-34-12-8-11-32-40(34)45(66)59(43(32)64)35-15-17-38(62)51-42(35)63/h8,11-12,14,16,23-24,26,30,35H,3-7,9-10,13,15,17-22,25H2,1-2H3,(H,49,61)(H,51,62,63)(H,47,48,50,52)","JSJGLYIYFOFJTA-UHFFFAOYSA-N"
"719","Q00534","CDK6","CRBN","","pal-pom","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","34.1","","Degradation of CDK6 in MDA-MB-231 cells after 18 h treatment","","","","","","","235","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","897.998","897.403440972","2.14","66","9","17","3","15","239.61","C46H51N13O7","InChI=1S/C46H51N13O7/c1-27-33-24-48-46(52-41(33)58(30-9-5-6-10-30)44(65)39(27)28(2)60)50-36-16-14-31(23-47-36)56-21-19-55(20-22-56)25-29-26-57(54-53-29)18-7-3-4-13-37(61)49-34-12-8-11-32-40(34)45(66)59(43(32)64)35-15-17-38(62)51-42(35)63/h8,11-12,14,16,23-24,26,30,35H,3-7,9-10,13,15,17-22,25H2,1-2H3,(H,49,61)(H,51,62,63)(H,47,48,50,52)","JSJGLYIYFOFJTA-UHFFFAOYSA-N"
"720","P11802","CDK4","CRBN","","pal-pom-2","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","883.971","883.387790908","1.79","65","9","17","3","14","239.61","C45H49N13O7","InChI=1S/C45H49N13O7/c1-26-32-23-47-45(51-40(32)57(29-8-3-4-9-29)43(64)38(26)27(2)59)49-35-15-13-30(22-46-35)55-20-18-54(19-21-55)24-28-25-56(53-52-28)17-6-5-12-36(60)48-33-11-7-10-31-39(33)44(65)58(42(31)63)34-14-16-37(61)50-41(34)62/h7,10-11,13,15,22-23,25,29,34H,3-6,8-9,12,14,16-21,24H2,1-2H3,(H,48,60)(H,50,61,62)(H,46,47,49,51)","LLDVUBRBILTBEV-UHFFFAOYSA-N"
"720","Q00534","CDK6","CRBN","","pal-pom-2","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","883.971","883.387790908","1.79","65","9","17","3","14","239.61","C45H49N13O7","InChI=1S/C45H49N13O7/c1-26-32-23-47-45(51-40(32)57(29-8-3-4-9-29)43(64)38(26)27(2)59)49-35-15-13-30(22-46-35)55-20-18-54(19-21-55)24-28-25-56(53-52-28)17-6-5-12-36(60)48-33-11-7-10-31-39(33)44(65)58(42(31)63)34-14-16-37(61)50-41(34)62/h7,10-11,13,15,22-23,25,29,34H,3-6,8-9,12,14,16-21,24H2,1-2H3,(H,48,60)(H,50,61,62)(H,46,47,49,51)","LLDVUBRBILTBEV-UHFFFAOYSA-N"
"721","P11802","CDK4","CRBN","","rib-pom","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N1C1CCCC1","97","","Degradation of CDK4 in MDA-MB-231 cells after 18 h treatment","","","","","","","1650","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","885.003","884.419425384","2.52","65","9","16","3","15","225.78","C45H52N14O6","InChI=1S/C45H52N14O6/c1-54(2)43(64)35-23-28-24-47-45(51-40(28)58(35)30-9-5-6-10-30)49-36-16-14-31(25-46-36)56-21-19-55(20-22-56)26-29-27-57(53-52-29)18-7-3-4-13-37(60)48-33-12-8-11-32-39(33)44(65)59(42(32)63)34-15-17-38(61)50-41(34)62/h8,11-12,14,16,23-25,27,30,34H,3-7,9-10,13,15,17-22,26H2,1-2H3,(H,48,60)(H,50,61,62)(H,46,47,49,51)","JYILVSNNISWWAT-UHFFFAOYSA-N"
"721","Q00534","CDK6","CRBN","","rib-pom","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N1C1CCCC1","300","","Degradation of CDK6 in MDA-MB-231 cells after 18 h treatment","","","","","","","6100","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","885.003","884.419425384","2.52","65","9","16","3","15","225.78","C45H52N14O6","InChI=1S/C45H52N14O6/c1-54(2)43(64)35-23-28-24-47-45(51-40(28)58(35)30-9-5-6-10-30)49-36-16-14-31(25-46-36)56-21-19-55(20-22-56)26-29-27-57(53-52-29)18-7-3-4-13-37(60)48-33-12-8-11-32-39(33)44(65)59(42(32)63)34-15-17-38(61)50-41(34)62/h8,11-12,14,16,23-25,27,30,34H,3-7,9-10,13,15,17-22,26H2,1-2H3,(H,48,60)(H,50,61,62)(H,46,47,49,51)","JYILVSNNISWWAT-UHFFFAOYSA-N"
"722","P11802","CDK4","CRBN","","rib-pom-2","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","870.976","870.40377532","2.16","64","9","16","3","14","225.78","C44H50N14O6","InChI=1S/C44H50N14O6/c1-53(2)42(63)34-22-27-23-46-44(50-39(27)57(34)29-8-3-4-9-29)48-35-15-13-30(24-45-35)55-20-18-54(19-21-55)25-28-26-56(52-51-28)17-6-5-12-36(59)47-32-11-7-10-31-38(32)43(64)58(41(31)62)33-14-16-37(60)49-40(33)61/h7,10-11,13,15,22-24,26,29,33H,3-6,8-9,12,14,16-21,25H2,1-2H3,(H,47,59)(H,49,60,61)(H,45,46,48,50)","MUNLYJLCNGWORN-UHFFFAOYSA-N"
"722","Q00534","CDK6","CRBN","","rib-pom-2","CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCCCC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)C=N3)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc00163h","870.976","870.40377532","2.16","64","9","16","3","14","225.78","C44H50N14O6","InChI=1S/C44H50N14O6/c1-53(2)42(63)34-22-27-23-46-44(50-39(27)57(34)29-8-3-4-9-29)48-35-15-13-30(24-45-35)55-20-18-54(19-21-55)25-28-26-56(52-51-28)17-6-5-12-36(59)47-32-11-7-10-31-38(32)43(64)58(41(31)62)33-14-16-37(60)49-40(33)61/h7,10-11,13,15,22-24,26,29,33H,3-6,8-9,12,14,16-21,25H2,1-2H3,(H,47,59)(H,49,60,61)(H,45,46,48,50)","MUNLYJLCNGWORN-UHFFFAOYSA-N"
"723","Q9UBN7","HDAC6","CRBN","","NH2","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(NC(=O)CCCC2=CN(CCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","3.2","","Degradation of HDAC6 in MM.1S cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08509b","836.907","836.360573116","2.09","61","6","13","6","20","246.29","C42H48N10O9","InChI=1S/C42H48N10O9/c1-2-3-21-50(25-27-10-12-28(13-11-27)38(55)48-60)42(59)45-30-16-14-29(15-17-30)44-35(53)9-4-6-31-26-51(49-47-31)22-24-61-23-20-43-33-8-5-7-32-37(33)41(58)52(40(32)57)34-18-19-36(54)46-39(34)56/h5,7-8,10-17,26,34,43,60H,2-4,6,9,18-25H2,1H3,(H,44,53)(H,45,59)(H,48,55)(H,46,54,56)","ASTBYSZIHNGCIB-UHFFFAOYSA-N"
"724","Q9UBN7","HDAC6","CRBN","","NH3","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(NC(=O)CCCC2=CN(CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08509b","880.96","880.386787864","1.94","64","6","14","6","23","255.52","C44H52N10O10","InChI=1S/C44H52N10O10/c1-2-3-21-52(27-29-10-12-30(13-11-29)40(57)50-62)44(61)47-32-16-14-31(15-17-32)46-37(55)9-4-6-33-28-53(51-49-33)22-24-64-26-25-63-23-20-45-35-8-5-7-34-39(35)43(60)54(42(34)59)36-18-19-38(56)48-41(36)58/h5,7-8,10-17,28,36,45,62H,2-4,6,9,18-27H2,1H3,(H,46,55)(H,47,61)(H,50,57)(H,48,56,58)","WWWRPNDLGWZRHY-UHFFFAOYSA-N"
"725","Q9UBN7","HDAC6","CRBN","","NH4","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(NC(=O)CCCC2=CN(CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08509b","925.013","924.413002612","1.79","67","6","15","6","26","264.75","C46H56N10O11","InChI=1S/C46H56N10O11/c1-2-3-21-54(29-31-10-12-32(13-11-31)42(59)52-64)46(63)49-34-16-14-33(15-17-34)48-39(57)9-4-6-35-30-55(53-51-35)22-24-66-26-28-67-27-25-65-23-20-47-37-8-5-7-36-41(37)45(62)56(44(36)61)38-18-19-40(58)50-43(38)60/h5,7-8,10-17,30,38,47,64H,2-4,6,9,18-29H2,1H3,(H,48,57)(H,49,63)(H,52,59)(H,50,58,60)","MHLPILXDONDCAZ-UHFFFAOYSA-N"
"726","Q9UBN7","HDAC6","CRBN","","NH5","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(NC(=O)CCCC2=CN(CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08509b","969.066","968.43921736","1.65","70","6","16","6","29","273.98","C48H60N10O12","InChI=1S/C48H60N10O12/c1-2-3-21-56(31-33-10-12-34(13-11-33)44(61)54-66)48(65)51-36-16-14-35(15-17-36)50-41(59)9-4-6-37-32-57(55-53-37)22-24-68-26-28-70-30-29-69-27-25-67-23-20-49-39-8-5-7-38-43(39)47(64)58(46(38)63)40-18-19-42(60)52-45(40)62/h5,7-8,10-17,32,40,49,66H,2-4,6,9,18-31H2,1H3,(H,50,59)(H,51,65)(H,54,61)(H,52,60,62)","SBMGKZNHFKRQJE-UHFFFAOYSA-N"
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"736","O60885","BRD4","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25.23/179.5","Inhibit growth of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115181","752.806","752.226447732","3.06","54","7","10","4","13","200.39","C38H36N6O9S","InChI=1S/C38H36N6O9S/c1-43-27-13-12-25(42-54(51,52)30-10-4-3-9-29(30)53-2)23-19-21(20-24(33(23)27)36(43)48)11-15-31(45)40-18-6-17-39-26-8-5-7-22-34(26)38(50)44(37(22)49)28-14-16-32(46)41-35(28)47/h3-5,7-10,12-13,19-20,28,39,42H,6,11,14-18H2,1-2H3,(H,40,45)(H,41,46,47)","SWZCXPIOYJHHJE-UHFFFAOYSA-N"
"737","P25440","BRD2","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.25/51.96","Inhibit growth of MV4-11/Molm-13 cells","","","32/20/31","Inhibit proliferation of MDA-MB-231/MDA-MB-468/MOLT-4 cells","","","","","","","","","","","10.1016/j.bmc.2019.115181","766.833","766.242097796","3.42","55","7","10","4","14","200.39","C39H38N6O9S","InChI=1S/C39H38N6O9S/c1-44-28-14-13-26(43-55(52,53)31-11-4-3-10-30(31)54-2)24-20-22(21-25(34(24)28)37(44)49)12-16-32(46)41-19-6-5-18-40-27-9-7-8-23-35(27)39(51)45(38(23)50)29-15-17-33(47)42-36(29)48/h3-4,7-11,13-14,20-21,29,40,43H,5-6,12,15-19H2,1-2H3,(H,41,46)(H,42,47,48)","DCPKSVYPNGBDSB-UHFFFAOYSA-N"
"737","Q15059","BRD3","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.25/51.96","Inhibit growth of MV4-11/Molm-13 cells","","","32/20/31","Inhibit proliferation of MDA-MB-231/MDA-MB-468/MOLT-4 cells","","","","","","","","","","","10.1016/j.bmc.2019.115181","766.833","766.242097796","3.42","55","7","10","4","14","200.39","C39H38N6O9S","InChI=1S/C39H38N6O9S/c1-44-28-14-13-26(43-55(52,53)31-11-4-3-10-30(31)54-2)24-20-22(21-25(34(24)28)37(44)49)12-16-32(46)41-19-6-5-18-40-27-9-7-8-23-35(27)39(51)45(38(23)50)29-15-17-33(47)42-36(29)48/h3-4,7-11,13-14,20-21,29,40,43H,5-6,12,15-19H2,1-2H3,(H,41,46)(H,42,47,48)","DCPKSVYPNGBDSB-UHFFFAOYSA-N"
"737","O60885","BRD4","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.25/51.96","Inhibit growth of MV4-11/Molm-13 cells","","","32/20/31","Inhibit proliferation of MDA-MB-231/MDA-MB-468/MOLT-4 cells","","","","","","","","","","","10.1016/j.bmc.2019.115181","766.833","766.242097796","3.42","55","7","10","4","14","200.39","C39H38N6O9S","InChI=1S/C39H38N6O9S/c1-44-28-14-13-26(43-55(52,53)31-11-4-3-10-30(31)54-2)24-20-22(21-25(34(24)28)37(44)49)12-16-32(46)41-19-6-5-18-40-27-9-7-8-23-35(27)39(51)45(38(23)50)29-15-17-33(47)42-36(29)48/h3-4,7-11,13-14,20-21,29,40,43H,5-6,12,15-19H2,1-2H3,(H,41,46)(H,42,47,48)","DCPKSVYPNGBDSB-UHFFFAOYSA-N"
"738","O60885","BRD4","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.18/176.7","Inhibit growth of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115181","780.86","780.25774786","3.78","56","7","10","4","15","200.39","C40H40N6O9S","InChI=1S/C40H40N6O9S/c1-45-29-15-14-27(44-56(53,54)32-12-5-4-11-31(32)55-2)25-21-23(22-26(35(25)29)38(45)50)13-17-33(47)42-20-7-3-6-19-41-28-10-8-9-24-36(28)40(52)46(39(24)51)30-16-18-34(48)43-37(30)49/h4-5,8-12,14-15,21-22,30,41,44H,3,6-7,13,16-20H2,1-2H3,(H,42,47)(H,43,48,49)","XZBGLBGHBZBCSY-UHFFFAOYSA-N"
"739","O60885","BRD4","CRBN","","","COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C13)C(=O)N2C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3429/>10000","Inhibit growth of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115181","794.887","794.273397924","4.13","57","7","10","4","16","200.39","C41H42N6O9S","InChI=1S/C41H42N6O9S/c1-46-30-16-15-28(45-57(54,55)33-13-6-5-12-32(33)56-2)26-22-24(23-27(36(26)30)39(46)51)14-18-34(48)43-21-8-4-3-7-20-42-29-11-9-10-25-37(29)41(53)47(40(25)52)31-17-19-35(49)44-38(31)50/h5-6,9-13,15-16,22-23,31,42,45H,3-4,7-8,14,17-21H2,1-2H3,(H,43,48)(H,44,49,50)","FPHFNVLXCWCNMO-UHFFFAOYSA-N"
"740","P11802","CDK4","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","25","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","32","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1016.327","1015.54660006","6.85","73","8","15","4","19","207.88","C55H73N11O6S","InChI=1S/C55H73N11O6S/c1-34-43-31-57-54(62-50(43)66(40-15-12-13-16-40)52(71)47(34)37(4)67)60-45-23-22-41(30-56-45)64-27-25-63(26-28-64)24-14-10-8-9-11-17-46(69)61-49(55(5,6)7)53(72)65-32-42(68)29-44(65)51(70)59-35(2)38-18-20-39(21-19-38)48-36(3)58-33-73-48/h18-23,30-31,33,35,40,42,44,49,68H,8-17,24-29,32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","ORKAKWRVOOOMDD-GUQASDBOSA-N"
"740","Q00534","CDK6","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","4","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","200","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1016.327","1015.54660006","6.85","73","8","15","4","19","207.88","C55H73N11O6S","InChI=1S/C55H73N11O6S/c1-34-43-31-57-54(62-50(43)66(40-15-12-13-16-40)52(71)47(34)37(4)67)60-45-23-22-41(30-56-45)64-27-25-63(26-28-64)24-14-10-8-9-11-17-46(69)61-49(55(5,6)7)53(72)65-32-42(68)29-44(65)51(70)59-35(2)38-18-20-39(21-19-38)48-36(3)58-33-73-48/h18-23,30-31,33,35,40,42,44,49,68H,8-17,24-29,32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","ORKAKWRVOOOMDD-GUQASDBOSA-N"
"741","P11802","CDK4","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","631","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","40","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1064.324","1063.53134392","4.35","76","8","18","4","22","235.57","C55H73N11O9S","InChI=1S/C55H73N11O9S/c1-34-43-30-57-54(62-50(43)66(40-10-8-9-11-40)52(71)47(34)37(4)67)60-45-17-16-41(29-56-45)64-20-18-63(19-21-64)22-23-73-24-25-74-26-27-75-32-46(69)61-49(55(5,6)7)53(72)65-31-42(68)28-44(65)51(70)59-35(2)38-12-14-39(15-13-38)48-36(3)58-33-76-48/h12-17,29-30,33,35,40,42,44,49,68H,8-11,18-28,31-32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","RSMLEVNIFFMOJA-GUQASDBOSA-N"
"741","P11802","CDK4","VHL","","CST620","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","32","","Degradation of CDK4 in MM.1S cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1540","Inhibit viability of HEL cells","","","","","","","","","","","","","","","10.1039/d0sc00167h","1064.324","1063.53134392","4.35","76","8","18","4","22","235.57","C55H73N11O9S","InChI=1S/C55H73N11O9S/c1-34-43-30-57-54(62-50(43)66(40-10-8-9-11-40)52(71)47(34)37(4)67)60-45-17-16-41(29-56-45)64-20-18-63(19-21-64)22-23-73-24-25-74-26-27-75-32-46(69)61-49(55(5,6)7)53(72)65-31-42(68)28-44(65)51(70)59-35(2)38-12-14-39(15-13-38)48-36(3)58-33-76-48/h12-17,29-30,33,35,40,42,44,49,68H,8-11,18-28,31-32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","RSMLEVNIFFMOJA-GUQASDBOSA-N"
"741","Q00534","CDK6","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","20","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","158","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1064.324","1063.53134392","4.35","76","8","18","4","22","235.57","C55H73N11O9S","InChI=1S/C55H73N11O9S/c1-34-43-30-57-54(62-50(43)66(40-10-8-9-11-40)52(71)47(34)37(4)67)60-45-17-16-41(29-56-45)64-20-18-63(19-21-64)22-23-73-24-25-74-26-27-75-32-46(69)61-49(55(5,6)7)53(72)65-31-42(68)28-44(65)51(70)59-35(2)38-12-14-39(15-13-38)48-36(3)58-33-76-48/h12-17,29-30,33,35,40,42,44,49,68H,8-11,18-28,31-32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","RSMLEVNIFFMOJA-GUQASDBOSA-N"
"741","Q00534","CDK6","VHL","","CST620","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","1.7","","Degradation of CDK6 in MM.1S cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1540","Inhibit viability of HEL cells","","","","","","","","","","","","","","","10.1039/d0sc00167h","1064.324","1063.53134392","4.35","76","8","18","4","22","235.57","C55H73N11O9S","InChI=1S/C55H73N11O9S/c1-34-43-30-57-54(62-50(43)66(40-10-8-9-11-40)52(71)47(34)37(4)67)60-45-17-16-41(29-56-45)64-20-18-63(19-21-64)22-23-73-24-25-74-26-27-75-32-46(69)61-49(55(5,6)7)53(72)65-31-42(68)28-44(65)51(70)59-35(2)38-12-14-39(15-13-38)48-36(3)58-33-76-48/h12-17,29-30,33,35,40,42,44,49,68H,8-11,18-28,31-32H2,1-7H3,(H,59,70)(H,61,69)(H,56,57,60,62)/t35-,42+,44-,49+/m0/s1","RSMLEVNIFFMOJA-GUQASDBOSA-N"
"742","P11802","CDK4","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","2512","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","32","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1135.403","1134.5684577","3.6","81","8","19","5","25","264.67","C58H78N12O10S","InChI=1S/C58H78N12O10S/c1-36-45-32-61-57(66-53(45)70(42-10-8-9-11-42)55(76)50(36)39(4)71)64-47-17-16-43(31-60-47)68-22-20-67(21-23-68)34-49(74)59-19-25-79-27-29-80-28-26-78-24-18-48(73)65-52(58(5,6)7)56(77)69-33-44(72)30-46(69)54(75)63-37(2)40-12-14-41(15-13-40)51-38(3)62-35-81-51/h12-17,31-32,35,37,42,44,46,52,72H,8-11,18-30,33-34H2,1-7H3,(H,59,74)(H,63,75)(H,65,73)(H,60,61,64,66)/t37-,44+,46-,52+/m0/s1","CTPCMILSWFJJJB-HANZASPOSA-N"
"742","Q00534","CDK6","VHL","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","200","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","126","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1135.403","1134.5684577","3.6","81","8","19","5","25","264.67","C58H78N12O10S","InChI=1S/C58H78N12O10S/c1-36-45-32-61-57(66-53(45)70(42-10-8-9-11-42)55(76)50(36)39(4)71)64-47-17-16-43(31-60-47)68-22-20-67(21-23-68)34-49(74)59-19-25-79-27-29-80-28-26-78-24-18-48(73)65-52(58(5,6)7)56(77)69-33-44(72)30-46(69)54(75)63-37(2)40-12-14-41(15-13-40)51-38(3)62-35-81-51/h12-17,31-32,35,37,42,44,46,52,72H,8-11,18-30,33-34H2,1-7H3,(H,59,74)(H,63,75)(H,65,73)(H,60,61,64,66)/t37-,44+,46-,52+/m0/s1","CTPCMILSWFJJJB-HANZASPOSA-N"
"743","P11802","CDK4","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","20","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","5","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1011.233","1010.56658446","5.63","73","7","14","5","20","215.89","C53H72F2N12O6","InChI=1S/C53H72F2N12O6/c1-32-38-30-58-52(63-47(38)67(36-16-12-13-17-36)50(72)44(32)34(3)68)60-42-22-21-37(29-57-42)65-26-24-64(25-27-65)23-14-10-8-9-11-20-43(69)59-35-28-41(49(71)61-45-39(54)18-15-19-40(45)55)66(31-35)51(73)46(53(4,5)6)62-48(70)33(2)56-7/h15,18-19,21-22,29-30,33,35-36,41,46,56H,8-14,16-17,20,23-28,31H2,1-7H3,(H,59,69)(H,61,71)(H,62,70)(H,57,58,60,63)/t33-,35-,41-,46+/m0/s1","OUTLYXINOACMSY-OYTRKBTESA-N"
"743","Q00534","CDK6","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","5","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","13","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1011.233","1010.56658446","5.63","73","7","14","5","20","215.89","C53H72F2N12O6","InChI=1S/C53H72F2N12O6/c1-32-38-30-58-52(63-47(38)67(36-16-12-13-17-36)50(72)44(32)34(3)68)60-42-22-21-37(29-57-42)65-26-24-64(25-27-65)23-14-10-8-9-11-20-43(69)59-35-28-41(49(71)61-45-39(54)18-15-19-40(45)55)66(31-35)51(73)46(53(4,5)6)62-48(70)33(2)56-7/h15,18-19,21-22,29-30,33,35-36,41,46,56H,8-14,16-17,20,23-28,31H2,1-7H3,(H,59,69)(H,61,71)(H,62,70)(H,57,58,60,63)/t33-,35-,41-,46+/m0/s1","OUTLYXINOACMSY-OYTRKBTESA-N"
"744","P11802","CDK4","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","79","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","6","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1059.23","1058.55132832","3.13","76","7","17","5","23","243.58","C53H72F2N12O9","InChI=1S/C53H72F2N12O9/c1-32-38-29-58-52(63-47(38)67(36-11-8-9-12-36)50(72)44(32)34(3)68)60-42-16-15-37(28-57-42)65-19-17-64(18-20-65)21-22-74-23-24-75-25-26-76-31-43(69)59-35-27-41(49(71)61-45-39(54)13-10-14-40(45)55)66(30-35)51(73)46(53(4,5)6)62-48(70)33(2)56-7/h10,13-16,28-29,33,35-36,41,46,56H,8-9,11-12,17-27,30-31H2,1-7H3,(H,59,69)(H,61,71)(H,62,70)(H,57,58,60,63)/t33-,35-,41-,46+/m0/s1","MFTRNYPINLZRSO-OYTRKBTESA-N"
"744","Q00534","CDK6","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","16","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","16","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1059.23","1058.55132832","3.13","76","7","17","5","23","243.58","C53H72F2N12O9","InChI=1S/C53H72F2N12O9/c1-32-38-29-58-52(63-47(38)67(36-11-8-9-12-36)50(72)44(32)34(3)68)60-42-16-15-37(28-57-42)65-19-17-64(18-20-65)21-22-74-23-24-75-25-26-76-31-43(69)59-35-27-41(49(71)61-45-39(54)13-10-14-40(45)55)66(30-35)51(73)46(53(4,5)6)62-48(70)33(2)56-7/h10,13-16,28-29,33,35-36,41,46,56H,8-9,11-12,17-27,30-31H2,1-7H3,(H,59,69)(H,61,71)(H,62,70)(H,57,58,60,63)/t33-,35-,41-,46+/m0/s1","MFTRNYPINLZRSO-OYTRKBTESA-N"
"745","P11802","CDK4","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCCNC(=O)CN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","5012","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","16","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1130.309","1129.5884421","2.37","81","7","18","6","26","272.68","C56H77F2N13O10","InChI=1S/C56H77F2N13O10/c1-34-40-31-62-55(67-50(40)71(38-11-8-9-12-38)53(77)47(34)36(3)72)64-44-16-15-39(30-61-44)69-21-19-68(20-22-69)33-46(74)60-18-24-80-26-28-81-27-25-79-23-17-45(73)63-37-29-43(52(76)65-48-41(57)13-10-14-42(48)58)70(32-37)54(78)49(56(4,5)6)66-51(75)35(2)59-7/h10,13-16,30-31,35,37-38,43,49,59H,8-9,11-12,17-29,32-33H2,1-7H3,(H,60,74)(H,63,73)(H,65,76)(H,66,75)(H,61,62,64,67)/t35-,37-,43-,49+/m0/s1","DNVODRITWXGBQB-TXCNDJKGSA-N"
"745","Q00534","CDK6","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCCNC(=O)CN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","1585","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","40","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","1130.309","1129.5884421","2.37","81","7","18","6","26","272.68","C56H77F2N13O10","InChI=1S/C56H77F2N13O10/c1-34-40-31-62-55(67-50(40)71(38-11-8-9-12-38)53(77)47(34)36(3)72)64-44-16-15-39(30-61-44)69-21-19-68(20-22-69)33-46(74)60-18-24-80-26-28-81-27-25-79-23-17-45(73)63-37-29-43(52(76)65-48-41(57)13-10-14-42(48)58)70(32-37)54(78)49(56(4,5)6)66-51(75)35(2)59-7/h10,13-16,30-31,35,37-38,43,49,59H,8-9,11-12,17-29,32-33H2,1-7H3,(H,60,74)(H,63,73)(H,65,76)(H,66,75)(H,61,62,64,67)/t35-,37-,43-,49+/m0/s1","DNVODRITWXGBQB-TXCNDJKGSA-N"
"746","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","50","","Degradation of CDK4 in Jurkat cells after 24 h treatment","","","6","Inhibition of CDK4-cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","891.987","891.402772276","1.77","65","8","17","4","18","239.39","C45H53N11O9","InChI=1S/C45H53N11O9/c1-27-32-25-49-45(52-40(32)55(29-6-3-4-7-29)43(62)38(27)28(2)57)50-35-12-10-30(24-48-35)54-17-15-53(16-18-54)19-21-65-23-22-64-20-14-46-37(59)26-47-33-9-5-8-31-39(33)44(63)56(42(31)61)34-11-13-36(58)51-41(34)60/h5,8-10,12,24-25,29,34,47H,3-4,6-7,11,13-23,26H2,1-2H3,(H,46,59)(H,51,58,60)(H,48,49,50,52)","JWNZXWGMBRXMPK-UHFFFAOYSA-N"
"746","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","5","","Degradation of CDK6 in Jurkat cells after 24 h treatment","","","16","Inhibition of CDK6-cyclin D3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127106","891.987","891.402772276","1.77","65","8","17","4","18","239.39","C45H53N11O9","InChI=1S/C45H53N11O9/c1-27-32-25-49-45(52-40(32)55(29-6-3-4-7-29)43(62)38(27)28(2)57)50-35-12-10-30(24-48-35)54-17-15-53(16-18-54)19-21-65-23-22-64-20-14-46-37(59)26-47-33-9-5-8-31-39(33)44(63)56(42(31)61)34-11-13-36(58)51-41(34)60/h5,8-10,12,24-25,29,34,47H,3-4,6-7,11,13-23,26H2,1-2H3,(H,46,59)(H,51,58,60)(H,48,49,50,52)","JWNZXWGMBRXMPK-UHFFFAOYSA-N"
"747","","BCR-ABL","cIAP1","","SNIPER(ABL)-1","CC1=CC=C(NC(=O)C2=CC=C(CNC(=O)CCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC3=CC=CC=C3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2016.09.041","799.977","799.416965796","4.48","59","5","10","7","20","213.35","C45H53N9O5","InChI=1S/C45H53N9O5/c1-29(2)24-39(52-44(59)41(56)36(46)25-31-10-5-4-6-11-31)43(58)48-22-8-7-13-40(55)50-27-32-15-17-33(18-16-32)42(57)51-35-19-14-30(3)38(26-35)54-45-49-23-20-37(53-45)34-12-9-21-47-28-34/h4-6,9-12,14-21,23,26,28-29,36,39,41,56H,7-8,13,22,24-25,27,46H2,1-3H3,(H,48,58)(H,50,55)(H,51,57)(H,52,59)(H,49,53,54)/t36-,39+,41+/m1/s1","DTODSQMGOYPDCV-UDEWTJCRSA-N"
"748","","BCR-ABL","cIAP1","","SNIPER(ABL)-2","CC1=CC=C(NC(=O)C2=CC=C(CNC(=O)CCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC3=CC=CC=C3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2016.09.041","828.031","827.448265924","5.37","61","5","10","7","22","213.35","C47H57N9O5","InChI=1S/C47H57N9O5/c1-31(2)26-41(54-46(61)43(58)38(48)27-33-12-7-6-8-13-33)45(60)50-24-10-5-4-9-15-42(57)52-29-34-17-19-35(20-18-34)44(59)53-37-21-16-32(3)40(28-37)56-47-51-25-22-39(55-47)36-14-11-23-49-30-36/h6-8,11-14,16-23,25,28,30-31,38,41,43,58H,4-5,9-10,15,24,26-27,29,48H2,1-3H3,(H,50,60)(H,52,57)(H,53,59)(H,54,61)(H,51,55,56)/t38-,41+,43+/m1/s1","ZEUAXPRXCJUPMU-XMOGEVODSA-N"
"749","","BCR-ABL","cIAP1","","SNIPER(ABL)-3","CC1=CC=C(NC(=O)C2=CC=C(CNC(=O)CCCCCCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC3=CC=CC=C3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2016.09.041","884.139","883.51086618","7.54","65","5","10","7","26","213.35","C51H65N9O5","InChI=1S/C51H65N9O5/c1-35(2)30-45(58-50(65)47(62)42(52)31-37-16-11-10-12-17-37)49(64)54-28-14-9-7-5-4-6-8-13-19-46(61)56-33-38-21-23-39(24-22-38)48(63)57-41-25-20-36(3)44(32-41)60-51-55-29-26-43(59-51)40-18-15-27-53-34-40/h10-12,15-18,20-27,29,32,34-35,42,45,47,62H,4-9,13-14,19,28,30-31,33,52H2,1-3H3,(H,54,64)(H,56,61)(H,57,63)(H,58,65)(H,55,59,60)/t42-,45+,47+/m1/s1","XGWLZLZJIVJHNU-IZBWAPRPSA-N"
"750","Q06187","BTK","VHL","","SJF638","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCN3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C5=C(N)N=CN=C54)CC3)C(C)(C)C)C=C2)SC=N1","374","49","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","945.16","944.43671526","5.34","68","8","15","4","18","212.18","C50H60N10O7S","InChI=1S/C50H60N10O7S/c1-32-44(68-31-55-32)35-12-10-33(11-13-35)27-52-48(63)40-26-37(61)28-59(40)49(64)45(50(2,3)4)56-41(62)29-66-25-24-65-23-22-58-20-18-36(19-21-58)60-47-42(46(51)53-30-54-47)43(57-60)34-14-16-39(17-15-34)67-38-8-6-5-7-9-38/h5-17,30-31,36-37,40,45,61H,18-29H2,1-4H3,(H,52,63)(H,56,62)(H2,51,53,54)/t37-,40+,45-/m1/s1","RIOHYDUGYNZWPD-DIKPJKDTSA-N"
"751","Q06187","BTK","VHL","","SJF678","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C(OCCCCOCCCCN3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C5=C(N)N=CN=C54)CC3)=C2)SC=N1","162","50","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","1061.323","1060.49931552","7.88","77","10","15","3","22","203.39","C59H68N10O7S","InChI=1S/C59H68N10O7S/c1-38(2)53(68-34-43-13-7-8-16-48(43)58(68)72)59(73)67-35-45(70)32-49(67)57(71)61-33-42-18-17-41(54-39(3)64-37-77-54)31-50(42)75-30-12-11-29-74-28-10-9-25-66-26-23-44(24-27-66)69-56-51(55(60)62-36-63-56)52(65-69)40-19-21-47(22-20-40)76-46-14-5-4-6-15-46/h4-8,13-22,31,36-38,44-45,49,53,70H,9-12,23-30,32-35H2,1-3H3,(H,61,71)(H2,60,62,63)/t45-,49+,53+/m1/s1","VFRJYHIRKCDWOQ-ABZCTAHRSA-N"
"752","Q06187","BTK","VHL","","SJF690","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C(OCCCOCCC(=O)N3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C5=C(N)N=CN=C54)CC3)=C2)SC=N1",">1000","","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","1047.252","1046.44727994","6.2","76","10","15","3","19","220.46","C57H62N10O8S","InChI=1S/C57H62N10O8S/c1-35(2)51(66-31-40-10-7-8-13-45(40)56(66)71)57(72)65-32-42(68)29-46(65)55(70)59-30-39-15-14-38(52-36(3)62-34-76-52)28-47(39)74-26-9-25-73-27-22-48(69)64-23-20-41(21-24-64)67-54-49(53(58)60-33-61-54)50(63-67)37-16-18-44(19-17-37)75-43-11-5-4-6-12-43/h4-8,10-19,28,33-35,41-42,46,51,68H,9,20-27,29-32H2,1-3H3,(H,59,70)(H2,58,60,61)/t42-,46+,51+/m1/s1","YAKBRBQHMAONAH-QSDOZQHJSA-N"
"753","Q06187","BTK","CRBN","","SJF608","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCCOC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","8.3","91","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","774.835","774.312560304","3.1","57","8","14","2","15","193.33","C41H42N8O8","InChI=1S/C41H42N8O8/c42-37-35-36(26-6-8-29(9-7-26)57-28-4-2-1-3-5-28)46-49(38(35)44-25-43-37)27-14-16-47(17-15-27)18-19-54-20-21-55-22-23-56-30-10-11-31-32(24-30)41(53)48(40(31)52)33-12-13-34(50)45-39(33)51/h1-11,24-25,27,33H,12-23H2,(H2,42,43,44)(H,45,50,51)","KCRCMDOSXFUJPF-UHFFFAOYSA-N"
"754","Q06187","BTK","CRBN","","SJF620","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCCOC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)CC3=C2)CC1","7.9","95","Degradation of BTK in NAMALWA cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2019.126877","760.852","760.333295748","3.15","56","8","13","2","15","176.26","C41H44N8O7","InChI=1S/C41H44N8O7/c42-38-36-37(27-6-8-31(9-7-27)56-30-4-2-1-3-5-30)46-49(39(36)44-26-43-38)29-14-16-47(17-15-29)18-19-53-20-21-54-22-23-55-32-10-11-33-28(24-32)25-48(41(33)52)34-12-13-35(50)45-40(34)51/h1-11,24,26,29,34H,12-23,25H2,(H2,42,43,44)(H,45,50,51)","UJJYPBWMGIPXOE-UHFFFAOYSA-N"
"755","P23458","JAK1","XIAP","","JP-2","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCN2C=C(NC3=NC=C(Cl)C(NCC4=CC(F)=CC=C4F)=N3)C=N2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","63.1","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","972.627","971.511233776","8.55","69","7","11","6","23","187.3","C51H68ClF2N11O4","InChI=1S/C51H68ClF2N11O4/c1-33(55-2)48(67)62-46(35-17-9-8-10-18-35)50(69)65-32-38(27-44(65)49(68)61-43-21-15-19-34-16-12-13-20-40(34)43)59-45(66)22-11-6-4-3-5-7-14-25-64-31-39(29-58-64)60-51-57-30-41(52)47(63-51)56-28-36-26-37(53)23-24-42(36)54/h12-13,16,20,23-24,26,29-31,33,35,38,43-44,46,55H,3-11,14-15,17-19,21-22,25,27-28,32H2,1-2H3,(H,59,66)(H,61,68)(H,62,67)(H2,56,57,60,63)/t33-,38-,43+,44-,46-/m0/s1","YHXPOJGWUNGCCI-PUNCXHJESA-N"
"755","O60674","JAK2","XIAP","","JP-2","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCN2C=C(NC3=NC=C(Cl)C(NCC4=CC(F)=CC=C4F)=N3)C=N2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","79.4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","972.627","971.511233776","8.55","69","7","11","6","23","187.3","C51H68ClF2N11O4","InChI=1S/C51H68ClF2N11O4/c1-33(55-2)48(67)62-46(35-17-9-8-10-18-35)50(69)65-32-38(27-44(65)49(68)61-43-21-15-19-34-16-12-13-20-40(34)43)59-45(66)22-11-6-4-3-5-7-14-25-64-31-39(29-58-64)60-51-57-30-41(52)47(63-51)56-28-36-26-37(53)23-24-42(36)54/h12-13,16,20,23-24,26,29-31,33,35,38,43-44,46,55H,3-11,14-15,17-19,21-22,25,27-28,32H2,1-2H3,(H,59,66)(H,61,68)(H,62,67)(H2,56,57,60,63)/t33-,38-,43+,44-,46-/m0/s1","YHXPOJGWUNGCCI-PUNCXHJESA-N"
"756","P23458","JAK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCN3C=C(NC4=NC=C(Cl)C(NCC5=CC(F)=CC=C5F)=N4)C=N3)C(C)(C)C)C=C2)SC=N1","","","","","","31.6","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","919.544","918.394155424","8.22","64","6","12","5","21","179.29","C46H57ClF2N10O4S","InChI=1S/C46H57ClF2N10O4S/c1-29-40(64-28-53-29)31-15-13-30(14-16-31)22-51-43(62)38-21-35(60)27-59(38)44(63)41(46(2,3)4)56-39(61)12-10-8-6-5-7-9-11-19-58-26-34(24-54-58)55-45-52-25-36(47)42(57-45)50-23-32-20-33(48)17-18-37(32)49/h13-18,20,24-26,28,35,38,41,60H,5-12,19,21-23,27H2,1-4H3,(H,51,62)(H,56,61)(H2,50,52,55,57)/t35-,38+,41-/m1/s1","UQQCDWHCDPKOHW-LFHXYJAASA-N"
"756","O60674","JAK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCN3C=C(NC4=NC=C(Cl)C(NCC5=CC(F)=CC=C5F)=N4)C=N3)C(C)(C)C)C=C2)SC=N1","","","","","","79.4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","919.544","918.394155424","8.22","64","6","12","5","21","179.29","C46H57ClF2N10O4S","InChI=1S/C46H57ClF2N10O4S/c1-29-40(64-28-53-29)31-15-13-30(14-16-31)22-51-43(62)38-21-35(60)27-59(38)44(63)41(46(2,3)4)56-39(61)12-10-8-6-5-7-9-11-19-58-26-34(24-54-58)55-45-52-25-36(47)42(57-45)50-23-32-20-33(48)17-18-37(32)49/h13-18,20,24-26,28,35,38,41,60H,5-12,19,21-23,27H2,1-4H3,(H,51,62)(H,56,61)(H2,50,52,55,57)/t35-,38+,41-/m1/s1","UQQCDWHCDPKOHW-LFHXYJAASA-N"
"757","P23458","JAK1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCCCN4C=C(NC5=NC=C(Cl)C(NCC6=CC(F)=CC=C6F)=N5)C=N4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","748.235","747.28598488","5.26","53","6","10","4","17","163.24","C37H40ClF2N9O4","InChI=1S/C37H40ClF2N9O4/c38-28-20-42-37(47-34(28)41-18-23-17-24(39)12-13-29(23)40)44-25-19-43-48(21-25)16-7-5-3-1-2-4-6-11-32(50)45-30-10-8-9-26-27(30)22-49(36(26)53)31-14-15-33(51)46-35(31)52/h8-10,12-13,17,19-21,31H,1-7,11,14-16,18,22H2,(H,45,50)(H,46,51,52)(H2,41,42,44,47)","JSTLWCARHCKNPZ-UHFFFAOYSA-N"
"757","O60674","JAK2","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCCCN4C=C(NC5=NC=C(Cl)C(NCC6=CC(F)=CC=C6F)=N5)C=N4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","10","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","748.235","747.28598488","5.26","53","6","10","4","17","163.24","C37H40ClF2N9O4","InChI=1S/C37H40ClF2N9O4/c38-28-20-42-37(47-34(28)41-18-23-17-24(39)12-13-29(23)40)44-25-19-43-48(21-25)16-7-5-3-1-2-4-6-11-32(50)45-30-10-8-9-26-27(30)22-49(36(26)53)31-14-15-33(51)46-35(31)52/h8-10,12-13,17,19-21,31H,1-7,11,14-16,18,22H2,(H,45,50)(H,46,51,52)(H2,41,42,44,47)","JSTLWCARHCKNPZ-UHFFFAOYSA-N"
"758","P23458","JAK1","XIAP","","JP-1","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2C=C(NC3=NC=C(Cl)C(NCC4=CC(F)=CC=C4F)=N3)C=N2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","10","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1036.623","1035.49089226","4.82","73","7","15","6","27","224.22","C51H68ClF2N11O8","InChI=1S/C51H68ClF2N11O8/c1-33(55-2)48(67)62-46(35-10-4-3-5-11-35)50(69)65-31-38(26-44(65)49(68)61-43-14-8-12-34-9-6-7-13-40(34)43)59-45(66)32-73-24-23-72-22-21-71-20-19-70-18-17-64-30-39(28-58-64)60-51-57-29-41(52)47(63-51)56-27-36-25-37(53)15-16-42(36)54/h6-7,9,13,15-16,25,28-30,33,35,38,43-44,46,55H,3-5,8,10-12,14,17-24,26-27,31-32H2,1-2H3,(H,59,66)(H,61,68)(H,62,67)(H2,56,57,60,63)/t33-,38-,43+,44-,46-/m0/s1","HXOQAIRAFZBAGK-PUNCXHJESA-N"
"758","O60674","JAK2","XIAP","","JP-1","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2C=C(NC3=NC=C(Cl)C(NCC4=CC(F)=CC=C4F)=N3)C=N2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","6.3","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1036.623","1035.49089226","4.82","73","7","15","6","27","224.22","C51H68ClF2N11O8","InChI=1S/C51H68ClF2N11O8/c1-33(55-2)48(67)62-46(35-10-4-3-5-11-35)50(69)65-31-38(26-44(65)49(68)61-43-14-8-12-34-9-6-7-13-40(34)43)59-45(66)32-73-24-23-72-22-21-71-20-19-70-18-17-64-30-39(28-58-64)60-51-57-29-41(52)47(63-51)56-27-36-25-37(53)15-16-42(36)54/h6-7,9,13,15-16,25,28-30,33,35,38,43-44,46,55H,3-5,8,10-12,14,17-24,26-27,31-32H2,1-2H3,(H,59,66)(H,61,68)(H,62,67)(H2,56,57,60,63)/t33-,38-,43+,44-,46-/m0/s1","HXOQAIRAFZBAGK-PUNCXHJESA-N"
"759","P23458","JAK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN3C=C(NC4=NC=C(Cl)C(NCC5=CC(F)=CC=C5F)=N4)C=N3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","12.6","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","983.54","982.373813904","4.49","68","6","16","5","25","216.21","C46H57ClF2N10O8S","InChI=1S/C46H57ClF2N10O8S/c1-29-40(68-28-53-29)31-7-5-30(6-8-31)21-51-43(62)38-20-35(60)26-59(38)44(63)41(46(2,3)4)56-39(61)27-67-18-17-66-16-15-65-14-13-64-12-11-58-25-34(23-54-58)55-45-52-24-36(47)42(57-45)50-22-32-19-33(48)9-10-37(32)49/h5-10,19,23-25,28,35,38,41,60H,11-18,20-22,26-27H2,1-4H3,(H,51,62)(H,56,61)(H2,50,52,55,57)/t35-,38+,41-/m1/s1","ZZTHHMXNWQYUOO-LFHXYJAASA-N"
"759","O60674","JAK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN3C=C(NC4=NC=C(Cl)C(NCC5=CC(F)=CC=C5F)=N4)C=N3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","6.3","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","983.54","982.373813904","4.49","68","6","16","5","25","216.21","C46H57ClF2N10O8S","InChI=1S/C46H57ClF2N10O8S/c1-29-40(68-28-53-29)31-7-5-30(6-8-31)21-51-43(62)38-20-35(60)26-59(38)44(63)41(46(2,3)4)56-39(61)27-67-18-17-66-16-15-65-14-13-64-12-11-58-25-34(23-54-58)55-45-52-24-36(47)42(57-45)50-22-32-19-33(48)9-10-37(32)49/h5-10,19,23-25,28,35,38,41,60H,11-18,20-22,26-27H2,1-4H3,(H,51,62)(H,56,61)(H2,50,52,55,57)/t35-,38+,41-/m1/s1","ZZTHHMXNWQYUOO-LFHXYJAASA-N"
"760","P23458","JAK1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)COCCOCCOCCOCCN4C=C(NC5=NC=C(Cl)C(NCC6=CC(F)=CC=C6F)=N5)C=N4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","5","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39811","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","812.231","811.26564336","1.53","57","6","14","4","21","200.16","C37H40ClF2N9O8","InChI=1S/C37H40ClF2N9O8/c38-28-19-42-37(47-34(28)41-17-23-16-24(39)4-5-29(23)40)44-25-18-43-48(20-25)8-9-54-10-11-55-12-13-56-14-15-57-22-33(51)45-30-3-1-2-26-27(30)21-49(36(26)53)31-6-7-32(50)46-35(31)52/h1-5,16,18-20,31H,6-15,17,21-22H2,(H,45,51)(H,46,50,52)(H2,41,42,44,47)","ANVHTRZROROKIQ-UHFFFAOYSA-N"
"760","O60674","JAK2","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)COCCOCCOCCOCCN4C=C(NC5=NC=C(Cl)C(NCC6=CC(F)=CC=C6F)=N5)C=N4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","7.9","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39811","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","812.231","811.26564336","1.53","57","6","14","4","21","200.16","C37H40ClF2N9O8","InChI=1S/C37H40ClF2N9O8/c38-28-19-42-37(47-34(28)41-17-23-16-24(39)4-5-29(23)40)44-25-18-43-48(20-25)8-9-54-10-11-55-12-13-56-14-15-57-22-33(51)45-30-3-1-2-26-27(30)21-49(36(26)53)31-6-7-32(50)46-35(31)52/h1-5,16,18-20,31H,6-15,17,21-22H2,(H,45,51)(H,46,50,52)(H2,41,42,44,47)","ANVHTRZROROKIQ-UHFFFAOYSA-N"
"761","P23458","JAK1","XIAP","","JP-4","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","20","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1002.653","1001.52179846","8.59","71","7","12","6","24","196.53","C52H70ClF2N11O5","InChI=1S/C52H70ClF2N11O5/c1-33(56-2)49(68)63-47(35-18-10-9-11-19-35)51(70)66-32-38(27-43(66)50(69)62-42-22-16-20-34-17-13-14-21-40(34)42)60-45(67)23-12-7-5-4-6-8-15-24-71-44-26-37(54)25-36(46(44)55)28-57-48-41(53)30-58-52(64-48)61-39-29-59-65(3)31-39/h13-14,17,21,25-26,29-31,33,35,38,42-43,47,56H,4-12,15-16,18-20,22-24,27-28,32H2,1-3H3,(H,60,67)(H,62,69)(H,63,68)(H2,57,58,61,64)/t33-,38-,42+,43-,47-/m0/s1","QMYABPOYGMQHGL-ICKVPMRUSA-N"
"761","O60674","JAK2","XIAP","","JP-4","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","63.1","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1002.653","1001.52179846","8.59","71","7","12","6","24","196.53","C52H70ClF2N11O5","InChI=1S/C52H70ClF2N11O5/c1-33(56-2)49(68)63-47(35-18-10-9-11-19-35)51(70)66-32-38(27-43(66)50(69)62-42-22-16-20-34-17-13-14-21-40(34)42)60-45(67)23-12-7-5-4-6-8-15-24-71-44-26-37(54)25-36(46(44)55)28-57-48-41(53)30-58-52(64-48)61-39-29-59-65(3)31-39/h13-14,17,21,25-26,29-31,33,35,38,42-43,47,56H,4-12,15-16,18-20,22-24,27-28,32H2,1-3H3,(H,60,67)(H,62,69)(H,63,68)(H2,57,58,61,64)/t33-,38-,42+,43-,47-/m0/s1","QMYABPOYGMQHGL-ICKVPMRUSA-N"
"762","P23458","JAK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","7.9","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","949.57","948.404720108","8.26","66","6","13","5","22","188.52","C47H59ClF2N10O5S","InChI=1S/C47H59ClF2N10O5S/c1-29-41(66-28-54-29)31-16-14-30(15-17-31)22-52-44(63)37-21-35(61)27-60(37)45(64)42(47(2,3)4)57-39(62)13-11-9-7-6-8-10-12-18-65-38-20-33(49)19-32(40(38)50)23-51-43-36(48)25-53-46(58-43)56-34-24-55-59(5)26-34/h14-17,19-20,24-26,28,35,37,42,61H,6-13,18,21-23,27H2,1-5H3,(H,52,63)(H,57,62)(H2,51,53,56,58)/t35-,37+,42-/m1/s1","RQQGLRMODGJILS-YTKUFENASA-N"
"762","O60674","JAK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","251.2","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","949.57","948.404720108","8.26","66","6","13","5","22","188.52","C47H59ClF2N10O5S","InChI=1S/C47H59ClF2N10O5S/c1-29-41(66-28-54-29)31-16-14-30(15-17-31)22-52-44(63)37-21-35(61)27-60(37)45(64)42(47(2,3)4)57-39(62)13-11-9-7-6-8-10-12-18-65-38-20-33(49)19-32(40(38)50)23-51-43-36(48)25-53-46(58-43)56-34-24-55-59(5)26-34/h14-17,19-20,24-26,28,35,37,42,61H,6-13,18,21-23,27H2,1-5H3,(H,52,63)(H,57,62)(H2,51,53,56,58)/t35-,37+,42-/m1/s1","RQQGLRMODGJILS-YTKUFENASA-N"
"763","P23458","JAK1","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCCCCCCCCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","2.5","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5012","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","778.261","777.296549564","5.3","55","6","11","4","18","172.47","C38H42ClF2N9O5","InChI=1S/C38H42ClF2N9O5/c1-49-21-25(19-44-49)45-38-43-20-28(39)35(48-38)42-18-23-16-24(40)17-31(34(23)41)55-15-8-6-4-2-3-5-7-12-32(51)46-29-11-9-10-26-27(29)22-50(37(26)54)30-13-14-33(52)47-36(30)53/h9-11,16-17,19-21,30H,2-8,12-15,18,22H2,1H3,(H,46,51)(H,47,52,53)(H2,42,43,45,48)","PFLXRQOVRXRBAX-UHFFFAOYSA-N"
"763","O60674","JAK2","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCCCCCCCCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","79.4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5012","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","778.261","777.296549564","5.3","55","6","11","4","18","172.47","C38H42ClF2N9O5","InChI=1S/C38H42ClF2N9O5/c1-49-21-25(19-44-49)45-38-43-20-28(39)35(48-38)42-18-23-16-24(40)17-31(34(23)41)55-15-8-6-4-2-3-5-7-12-32(51)46-29-11-9-10-26-27(29)22-50(37(26)54)30-13-14-33(52)47-36(30)53/h9-11,16-17,19-21,30H,2-8,12-15,18,22H2,1H3,(H,46,51)(H,47,52,53)(H2,42,43,45,48)","PFLXRQOVRXRBAX-UHFFFAOYSA-N"
"764","P23458","JAK1","XIAP","","JP-3","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","2.5","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1066.649","1065.50145694","4.86","75","7","16","6","28","233.45","C52H70ClF2N11O9","InChI=1S/C52H70ClF2N11O9/c1-33(56-2)49(68)63-47(35-11-5-4-6-12-35)51(70)66-31-38(26-43(66)50(69)62-42-15-9-13-34-10-7-8-14-40(34)42)60-45(67)32-74-21-20-72-17-16-71-18-19-73-22-23-75-44-25-37(54)24-36(46(44)55)27-57-48-41(53)29-58-52(64-48)61-39-28-59-65(3)30-39/h7-8,10,14,24-25,28-30,33,35,38,42-43,47,56H,4-6,9,11-13,15-23,26-27,31-32H2,1-3H3,(H,60,67)(H,62,69)(H,63,68)(H2,57,58,61,64)/t33-,38-,42+,43-,47-/m0/s1","IWGAWFFLOTUTSG-ICKVPMRUSA-N"
"764","O60674","JAK2","XIAP","","JP-3","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","25.1","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1066.649","1065.50145694","4.86","75","7","16","6","28","233.45","C52H70ClF2N11O9","InChI=1S/C52H70ClF2N11O9/c1-33(56-2)49(68)63-47(35-11-5-4-6-12-35)51(70)66-31-38(26-43(66)50(69)62-42-15-9-13-34-10-7-8-14-40(34)42)60-45(67)32-74-21-20-72-17-16-71-18-19-73-22-23-75-44-25-37(54)24-36(46(44)55)27-57-48-41(53)29-58-52(64-48)61-39-28-59-65(3)30-39/h7-8,10,14,24-25,28-30,33,35,38,42-43,47,56H,4-6,9,11-13,15-23,26-27,31-32H2,1-3H3,(H,60,67)(H,62,69)(H,63,68)(H2,57,58,61,64)/t33-,38-,42+,43-,47-/m0/s1","IWGAWFFLOTUTSG-ICKVPMRUSA-N"
"765","P23458","JAK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","3.2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5012","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1013.566","1012.38437859","4.52","70","6","17","5","26","225.44","C47H59ClF2N10O9S","InChI=1S/C47H59ClF2N10O9S/c1-29-41(70-28-54-29)31-8-6-30(7-9-31)21-52-44(63)37-20-35(61)26-60(37)45(64)42(47(2,3)4)57-39(62)27-68-15-14-66-11-10-65-12-13-67-16-17-69-38-19-33(49)18-32(40(38)50)22-51-43-36(48)24-53-46(58-43)56-34-23-55-59(5)25-34/h6-9,18-19,23-25,28,35,37,42,61H,10-17,20-22,26-27H2,1-5H3,(H,52,63)(H,57,62)(H2,51,53,56,58)/t35-,37+,42-/m1/s1","OOGRLHGJCRPASG-YTKUFENASA-N"
"765","O60674","JAK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","20","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5012","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1013.566","1012.38437859","4.52","70","6","17","5","26","225.44","C47H59ClF2N10O9S","InChI=1S/C47H59ClF2N10O9S/c1-29-41(70-28-54-29)31-8-6-30(7-9-31)21-52-44(63)37-20-35(61)26-60(37)45(64)42(47(2,3)4)57-39(62)27-68-15-14-66-11-10-65-12-13-67-16-17-69-38-19-33(49)18-32(40(38)50)22-51-43-36(48)24-53-46(58-43)56-34-23-55-59(5)25-34/h6-9,18-19,23-25,28,35,37,42,61H,10-17,20-22,26-27H2,1-5H3,(H,52,63)(H,57,62)(H2,51,53,56,58)/t35-,37+,42-/m1/s1","OOGRLHGJCRPASG-YTKUFENASA-N"
"766","P23458","JAK1","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","3.2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","842.257","841.276208044","1.57","59","6","15","4","22","209.39","C38H42ClF2N9O9","InChI=1S/C38H42ClF2N9O9/c1-49-20-25(18-44-49)45-38-43-19-28(39)35(48-38)42-17-23-15-24(40)16-31(34(23)41)59-14-13-57-10-9-55-7-8-56-11-12-58-22-33(52)46-29-4-2-3-26-27(29)21-50(37(26)54)30-5-6-32(51)47-36(30)53/h2-4,15-16,18-20,30H,5-14,17,21-22H2,1H3,(H,46,52)(H,47,51,53)(H2,42,43,45,48)","UABKQGXBHNHGGJ-UHFFFAOYSA-N"
"766","O60674","JAK2","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","25.1","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","842.257","841.276208044","1.57","59","6","15","4","22","209.39","C38H42ClF2N9O9","InChI=1S/C38H42ClF2N9O9/c1-49-20-25(18-44-49)45-38-43-19-28(39)35(48-38)42-17-23-15-24(40)16-31(34(23)41)59-14-13-57-10-9-55-7-8-56-11-12-58-22-33(52)46-29-4-2-3-26-27(29)21-50(37(26)54)30-5-6-32(51)47-36(30)53/h2-4,15-16,18-20,30H,5-14,17,21-22H2,1H3,(H,46,52)(H,47,51,53)(H2,42,43,45,48)","UABKQGXBHNHGGJ-UHFFFAOYSA-N"
"767","P23458","JAK1","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","4","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1154.755","1153.55388644","4.56","81","7","18","6","34","251.91","C56H78ClF2N11O11","InChI=1S/C56H78ClF2N11O11/c1-37(60-2)53(72)67-51(39-11-5-4-6-12-39)55(74)70-35-42(30-47(70)54(73)66-46-15-9-13-38-10-7-8-14-44(38)46)64-49(71)36-80-25-24-78-21-20-76-17-16-75-18-19-77-22-23-79-26-27-81-48-29-41(58)28-40(50(48)59)31-61-52-45(57)33-62-56(68-52)65-43-32-63-69(3)34-43/h7-8,10,14,28-29,32-34,37,39,42,46-47,51,60H,4-6,9,11-13,15-27,30-31,35-36H2,1-3H3,(H,64,71)(H,66,73)(H,67,72)(H2,61,62,65,68)/t37-,42-,46+,47-,51-/m0/s1","WGHJABLIUKEPNB-XZCZLRKSSA-N"
"767","O60674","JAK2","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOC2=CC(F)=CC(CNC3=NC(NC4=CN(C)N=C4)=NC=C3Cl)=C2F)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","39.8","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1154.755","1153.55388644","4.56","81","7","18","6","34","251.91","C56H78ClF2N11O11","InChI=1S/C56H78ClF2N11O11/c1-37(60-2)53(72)67-51(39-11-5-4-6-12-39)55(74)70-35-42(30-47(70)54(73)66-46-15-9-13-38-10-7-8-14-44(38)46)64-49(71)36-80-25-24-78-21-20-76-17-16-75-18-19-77-22-23-79-26-27-81-48-29-41(58)28-40(50(48)59)31-61-52-45(57)33-62-56(68-52)65-43-32-63-69(3)34-43/h7-8,10,14,28-29,32-34,37,39,42,46-47,51,60H,4-6,9,11-13,15-27,30-31,35-36H2,1-3H3,(H,64,71)(H,66,73)(H,67,72)(H2,61,62,65,68)/t37-,42-,46+,47-,51-/m0/s1","WGHJABLIUKEPNB-XZCZLRKSSA-N"
"768","P23458","JAK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","3.2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1101.672","1100.43680808","4.23","76","6","19","5","32","243.9","C51H67ClF2N10O11S","InChI=1S/C51H67ClF2N10O11S/c1-33-45(76-32-58-33)35-8-6-34(7-9-35)25-56-48(67)41-24-39(65)30-64(41)49(68)46(51(2,3)4)61-43(66)31-74-19-18-72-15-14-70-11-10-69-12-13-71-16-17-73-20-21-75-42-23-37(53)22-36(44(42)54)26-55-47-40(52)28-57-50(62-47)60-38-27-59-63(5)29-38/h6-9,22-23,27-29,32,39,41,46,65H,10-21,24-26,30-31H2,1-5H3,(H,56,67)(H,61,66)(H2,55,57,60,62)/t39-,41+,46-/m1/s1","OPHJDILLGXTILW-MSEXGENUSA-N"
"768","O60674","JAK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOC3=CC(F)=CC(CNC4=NC(NC5=CN(C)N=C5)=NC=C4Cl)=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","25.1","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1101.672","1100.43680808","4.23","76","6","19","5","32","243.9","C51H67ClF2N10O11S","InChI=1S/C51H67ClF2N10O11S/c1-33-45(76-32-58-33)35-8-6-34(7-9-35)25-56-48(67)41-24-39(65)30-64(41)49(68)46(51(2,3)4)61-43(66)31-74-19-18-72-15-14-70-11-10-69-12-13-71-16-17-73-20-21-75-42-23-37(53)22-36(44(42)54)26-55-47-40(52)28-57-50(62-47)60-38-27-59-63(5)29-38/h6-9,22-23,27-29,32,39,41,46,65H,10-21,24-26,30-31H2,1-5H3,(H,56,67)(H,61,66)(H2,55,57,60,62)/t39-,41+,46-/m1/s1","OPHJDILLGXTILW-MSEXGENUSA-N"
"769","P23458","JAK1","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCOCCOCCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","930.363","929.32863754","1.28","65","6","17","4","28","227.85","C42H50ClF2N9O11","InChI=1S/C42H50ClF2N9O11/c1-53-24-29(22-48-53)49-42-47-23-32(43)39(52-42)46-21-27-19-28(44)20-35(38(27)45)65-18-17-63-14-13-61-10-9-59-7-8-60-11-12-62-15-16-64-26-37(56)50-33-4-2-3-30-31(33)25-54(41(30)58)34-5-6-36(55)51-40(34)57/h2-4,19-20,22-24,34H,5-18,21,25-26H2,1H3,(H,50,56)(H,51,55,57)(H2,46,47,49,52)","HNWMPDOKAMEJGV-UHFFFAOYSA-N"
"769","O60674","JAK2","CRBN","","","CN1C=C(NC2=NC=C(Cl)C(NCC3=CC(F)=CC(OCCOCCOCCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)=C3F)=N2)C=N1","","","","","","25.1","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","930.363","929.32863754","1.28","65","6","17","4","28","227.85","C42H50ClF2N9O11","InChI=1S/C42H50ClF2N9O11/c1-53-24-29(22-48-53)49-42-47-23-32(43)39(52-42)46-21-27-19-28(44)20-35(38(27)45)65-18-17-63-14-13-61-10-9-59-7-8-60-11-12-62-15-16-64-26-37(56)50-33-4-2-3-30-31(33)25-54(41(30)58)34-5-6-36(55)51-40(34)57/h2-4,19-20,22-24,34H,5-18,21,25-26H2,1H3,(H,50,56)(H,51,55,57)(H2,46,47,49,52)","HNWMPDOKAMEJGV-UHFFFAOYSA-N"
"770","P23458","JAK1","XIAP","","JP-6","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","251.2","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6310","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1273.647","1272.69448741","9.42","91","10","14","4","28","207.74","C70H94F2N10O8S","InChI=1S/C70H94F2N10O8S/c1-48(73-2)68(84)78-66(50-20-10-9-11-21-50)70(86)82-46-53(44-62(82)69(85)77-59-25-16-22-49-19-13-14-23-54(49)59)75-65(83)27-12-7-5-4-6-8-15-30-79-32-34-80(35-33-79)31-18-38-90-63-29-28-51(43-64(63)89-3)61-45-74-60-26-17-24-55(67(60)76-61)52-41-57(71)56(58(72)42-52)47-81-36-39-91(87,88)40-37-81/h13-14,17,19,23-24,26,28-29,41-43,45,48,50,53,59,62,66,73H,4-12,15-16,18,20-22,25,27,30-40,44,46-47H2,1-3H3,(H,75,83)(H,77,85)(H,78,84)/t48-,53-,59+,62-,66-/m0/s1","PMKTWIFESXFLMJ-TWOTYITNSA-N"
"770","O60674","JAK2","XIAP","","JP-6","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","2","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6310","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1273.647","1272.69448741","9.42","91","10","14","4","28","207.74","C70H94F2N10O8S","InChI=1S/C70H94F2N10O8S/c1-48(73-2)68(84)78-66(50-20-10-9-11-21-50)70(86)82-46-53(44-62(82)69(85)77-59-25-16-22-49-19-13-14-23-54(49)59)75-65(83)27-12-7-5-4-6-8-15-30-79-32-34-80(35-33-79)31-18-38-90-63-29-28-51(43-64(63)89-3)61-45-74-60-26-17-24-55(67(60)76-61)52-41-57(71)56(58(72)42-52)47-81-36-39-91(87,88)40-37-81/h13-14,17,19,23-24,26,28-29,41-43,45,48,50,53,59,62,66,73H,4-12,15-16,18,20-22,25,27,30-40,44,46-47H2,1-3H3,(H,75,83)(H,77,85)(H,78,84)/t48-,53-,59+,62-,66-/m0/s1","PMKTWIFESXFLMJ-TWOTYITNSA-N"
"771","P23458","JAK1","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","79.4","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15849","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1220.564","1219.57740906","9.09","86","9","15","3","26","199.73","C65H83F2N9O8S2","InChI=1S/C65H83F2N9O8S2/c1-44-61(85-43-70-44)46-20-18-45(19-21-46)39-69-63(79)56-38-49(77)41-76(56)64(80)62(65(2,3)4)72-59(78)17-11-9-7-6-8-10-12-24-73-26-28-74(29-27-73)25-14-32-84-57-23-22-47(37-58(57)83-5)55-40-68-54-16-13-15-50(60(54)71-55)48-35-52(66)51(53(67)36-48)42-75-30-33-86(81,82)34-31-75/h13,15-16,18-23,35-37,40,43,49,56,62,77H,6-12,14,17,24-34,38-39,41-42H2,1-5H3,(H,69,79)(H,72,78)/t49-,56+,62-/m1/s1","MFACUCAEIMHUKD-CZVVMYHNSA-N"
"771","O60674","JAK2","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","2","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15849","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1220.564","1219.57740906","9.09","86","9","15","3","26","199.73","C65H83F2N9O8S2","InChI=1S/C65H83F2N9O8S2/c1-44-61(85-43-70-44)46-20-18-45(19-21-46)39-69-63(79)56-38-49(77)41-76(56)64(80)62(65(2,3)4)72-59(78)17-11-9-7-6-8-10-12-24-73-26-28-74(29-27-73)25-14-32-84-57-23-22-47(37-58(57)83-5)55-40-68-54-16-13-15-50(60(54)71-55)48-35-52(66)51(53(67)36-48)42-75-30-33-86(81,82)34-31-75/h13,15-16,18-23,35-37,40,43,49,56,62,77H,6-12,14,17,24-34,38-39,41-42H2,1-5H3,(H,69,79)(H,72,78)/t49-,56+,62-/m1/s1","MFACUCAEIMHUKD-CZVVMYHNSA-N"
"772","P23458","JAK1","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCCCCCCCCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","63.1","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1049.255","1048.46923851","6.13","75","9","13","2","22","183.68","C56H66F2N8O8S","InChI=1S/C56H66F2N8O8S/c1-73-51-34-38(48-35-59-47-15-9-12-40(54(47)61-48)39-32-44(57)43(45(58)33-39)36-65-27-30-75(71,72)31-28-65)17-19-50(51)74-29-11-22-64-25-23-63(24-26-64)21-8-6-4-2-3-5-7-16-52(67)60-46-14-10-13-41-42(46)37-66(56(41)70)49-18-20-53(68)62-55(49)69/h9-10,12-15,17,19,32-35,49H,2-8,11,16,18,20-31,36-37H2,1H3,(H,60,67)(H,62,68,69)","FZFBKTHMERWOJN-UHFFFAOYSA-N"
"772","O60674","JAK2","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCCCCCCCCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1049.255","1048.46923851","6.13","75","9","13","2","22","183.68","C56H66F2N8O8S","InChI=1S/C56H66F2N8O8S/c1-73-51-34-38(48-35-59-47-15-9-12-40(54(47)61-48)39-32-44(57)43(45(58)33-39)36-65-27-30-75(71,72)31-28-65)17-19-50(51)74-29-11-22-64-25-23-63(24-26-64)21-8-6-4-2-3-5-7-16-52(67)60-46-14-10-13-41-42(46)37-66(56(41)70)49-18-20-53(68)62-55(49)69/h9-10,12-15,17,19,32-35,49H,2-8,11,16,18,20-31,36-37H2,1H3,(H,60,67)(H,62,68,69)","FZFBKTHMERWOJN-UHFFFAOYSA-N"
"773","P23458","JAK1","XIAP","","JP-5","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","79.4","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1337.643","1336.67414589","5.69","95","10","18","4","32","244.66","C70H94F2N10O12S","InChI=1S/C70H94F2N10O12S/c1-48(73-2)68(84)78-66(50-13-5-4-6-14-50)70(86)82-45-53(43-62(82)69(85)77-59-18-9-15-49-12-7-8-16-54(49)59)75-65(83)47-93-37-36-92-35-34-91-33-32-90-31-27-80-25-23-79(24-26-80)22-11-30-94-63-21-20-51(42-64(63)89-3)61-44-74-60-19-10-17-55(67(60)76-61)52-40-57(71)56(58(72)41-52)46-81-28-38-95(87,88)39-29-81/h7-8,10,12,16-17,19-21,40-42,44,48,50,53,59,62,66,73H,4-6,9,11,13-15,18,22-39,43,45-47H2,1-3H3,(H,75,83)(H,77,85)(H,78,84)/t48-,53-,59+,62-,66-/m0/s1","HJJLFXNMMWGGEX-TWOTYITNSA-N"
"773","O60674","JAK2","XIAP","","JP-5","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","2","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1337.643","1336.67414589","5.69","95","10","18","4","32","244.66","C70H94F2N10O12S","InChI=1S/C70H94F2N10O12S/c1-48(73-2)68(84)78-66(50-13-5-4-6-14-50)70(86)82-45-53(43-62(82)69(85)77-59-18-9-15-49-12-7-8-16-54(49)59)75-65(83)47-93-37-36-92-35-34-91-33-32-90-31-27-80-25-23-79(24-26-80)22-11-30-94-63-21-20-51(42-64(63)89-3)61-44-74-60-19-10-17-55(67(60)76-61)52-40-57(71)56(58(72)41-52)46-81-28-38-95(87,88)39-29-81/h7-8,10,12,16-17,19-21,40-42,44,48,50,53,59,62,66,73H,4-6,9,11,13-15,18,22-39,43,45-47H2,1-3H3,(H,75,83)(H,77,85)(H,78,84)/t48-,53-,59+,62-,66-/m0/s1","HJJLFXNMMWGGEX-TWOTYITNSA-N"
"774","P23458","JAK1","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","N.D.","","","","50.1","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1284.56","1283.55706754","5.35","90","9","19","3","30","236.65","C65H83F2N9O12S2","InChI=1S/C65H83F2N9O12S2/c1-44-61(89-43-70-44)46-12-10-45(11-13-46)38-69-63(79)56-37-49(77)40-76(56)64(80)62(65(2,3)4)72-59(78)42-87-31-30-86-29-28-85-27-26-84-25-21-74-19-17-73(18-20-74)16-7-24-88-57-15-14-47(36-58(57)83-5)55-39-68-54-9-6-8-50(60(54)71-55)48-34-52(66)51(53(67)35-48)41-75-22-32-90(81,82)33-23-75/h6,8-15,34-36,39,43,49,56,62,77H,7,16-33,37-38,40-42H2,1-5H3,(H,69,79)(H,72,78)/t49-,56+,62-/m1/s1","AQFFACIDFIVTBI-CZVVMYHNSA-N"
"774","O60674","JAK2","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","N.D.","","","","4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7943","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1284.56","1283.55706754","5.35","90","9","19","3","30","236.65","C65H83F2N9O12S2","InChI=1S/C65H83F2N9O12S2/c1-44-61(89-43-70-44)46-12-10-45(11-13-46)38-69-63(79)56-37-49(77)40-76(56)64(80)62(65(2,3)4)72-59(78)42-87-31-30-86-29-28-85-27-26-84-25-21-74-19-17-73(18-20-74)16-7-24-88-57-15-14-47(36-58(57)83-5)55-39-68-54-9-6-8-50(60(54)71-55)48-34-52(66)51(53(67)35-48)41-75-22-32-90(81,82)33-23-75/h6,8-15,34-36,39,43,49,56,62,77H,7,16-33,37-38,40-42H2,1-5H3,(H,69,79)(H,72,78)/t49-,56+,62-/m1/s1","AQFFACIDFIVTBI-CZVVMYHNSA-N"
"775","P23458","JAK1","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","12.6","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1113.251","1112.44889699","2.4","79","9","17","2","26","220.6","C56H66F2N8O12S","InChI=1S/C56H66F2N8O12S/c1-73-51-33-38(48-34-59-47-8-2-5-40(54(47)61-48)39-31-44(57)43(45(58)32-39)35-65-19-29-79(71,72)30-20-65)9-11-50(51)78-21-4-13-63-14-16-64(17-15-63)18-22-74-23-24-75-25-26-76-27-28-77-37-53(68)60-46-7-3-6-41-42(46)36-66(56(41)70)49-10-12-52(67)62-55(49)69/h2-3,5-9,11,31-34,49H,4,10,12-30,35-37H2,1H3,(H,60,68)(H,62,67,69)","UFVPZQSQNJNLLV-UHFFFAOYSA-N"
"775","O60674","JAK2","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","0.4","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1113.251","1112.44889699","2.4","79","9","17","2","26","220.6","C56H66F2N8O12S","InChI=1S/C56H66F2N8O12S/c1-73-51-33-38(48-34-59-47-8-2-5-40(54(47)61-48)39-31-44(57)43(45(58)32-39)35-65-19-29-79(71,72)30-20-65)9-11-50(51)78-21-4-13-63-14-16-64(17-15-63)18-22-74-23-24-75-25-26-76-27-28-77-37-53(68)60-46-7-3-6-41-42(46)36-66(56(41)70)49-10-12-52(67)62-55(49)69/h2-3,5-9,11,31-34,49H,4,10,12-30,35-37H2,1H3,(H,60,68)(H,62,67,69)","UFVPZQSQNJNLLV-UHFFFAOYSA-N"
"776","P23458","JAK1","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","100","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1425.749","1424.72657538","5.4","101","10","20","4","38","263.12","C74H102F2N10O14S","InChI=1S/C74H102F2N10O14S/c1-52(77-2)72(88)82-70(54-13-5-4-6-14-54)74(90)86-49-57(47-66(86)73(89)81-63-18-9-15-53-12-7-8-16-58(53)63)79-69(87)51-99-41-40-98-39-38-97-37-36-96-35-34-95-33-32-94-31-27-84-25-23-83(24-26-84)22-11-30-100-67-21-20-55(46-68(67)93-3)65-48-78-64-19-10-17-59(71(64)80-65)56-44-61(75)60(62(76)45-56)50-85-28-42-101(91,92)43-29-85/h7-8,10,12,16-17,19-21,44-46,48,52,54,57,63,66,70,77H,4-6,9,11,13-15,18,22-43,47,49-51H2,1-3H3,(H,79,87)(H,81,89)(H,82,88)/t52-,57-,63+,66-,70-/m0/s1","XPTXKJIMQGZDOF-MKQYPEAJSA-N"
"776","O60674","JAK2","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCN2CCN(CCCOC3=CC=C(C4=CN=C5C=CC=C(C6=CC(F)=C(CN7CCS(=O)(=O)CC7)C(F)=C6)C5=N4)C=C3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","3.2","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12589","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1425.749","1424.72657538","5.4","101","10","20","4","38","263.12","C74H102F2N10O14S","InChI=1S/C74H102F2N10O14S/c1-52(77-2)72(88)82-70(54-13-5-4-6-14-54)74(90)86-49-57(47-66(86)73(89)81-63-18-9-15-53-12-7-8-16-58(53)63)79-69(87)51-99-41-40-98-39-38-97-37-36-96-35-34-95-33-32-94-31-27-84-25-23-83(24-26-84)22-11-30-100-67-21-20-55(46-68(67)93-3)65-48-78-64-19-10-17-59(71(64)80-65)56-44-61(75)60(62(76)45-56)50-85-28-42-101(91,92)43-29-85/h7-8,10,12,16-17,19-21,44-46,48,52,54,57,63,66,70,77H,4-6,9,11,13-15,18,22-43,47,49-51H2,1-3H3,(H,79,87)(H,81,89)(H,82,88)/t52-,57-,63+,66-,70-/m0/s1","XPTXKJIMQGZDOF-MKQYPEAJSA-N"
"777","P23458","JAK1","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","125.9","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15849","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1372.666","1371.60949703","5.06","96","9","21","3","36","255.11","C69H91F2N9O14S2","InChI=1S/C69H91F2N9O14S2/c1-48-65(95-47-74-48)50-12-10-49(11-13-50)42-73-67(83)60-41-53(81)44-80(60)68(84)66(69(2,3)4)76-63(82)46-93-35-34-92-33-32-91-31-30-90-29-28-89-27-26-88-25-21-78-19-17-77(18-20-78)16-7-24-94-61-15-14-51(40-62(61)87-5)59-43-72-58-9-6-8-54(64(58)75-59)52-38-56(70)55(57(71)39-52)45-79-22-36-96(85,86)37-23-79/h6,8-15,38-40,43,47,53,60,66,81H,7,16-37,41-42,44-46H2,1-5H3,(H,73,83)(H,76,82)/t53-,60+,66-/m1/s1","UWAXAEFQHBGTLX-USUOEENBSA-N"
"777","O60674","JAK2","VHL","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","5","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15849","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1372.666","1371.60949703","5.06","96","9","21","3","36","255.11","C69H91F2N9O14S2","InChI=1S/C69H91F2N9O14S2/c1-48-65(95-47-74-48)50-12-10-49(11-13-50)42-73-67(83)60-41-53(81)44-80(60)68(84)66(69(2,3)4)76-63(82)46-93-35-34-92-33-32-91-31-30-90-29-28-89-27-26-88-25-21-78-19-17-77(18-20-78)16-7-24-94-61-15-14-51(40-62(61)87-5)59-43-72-58-9-6-8-54(64(58)75-59)52-38-56(70)55(57(71)39-52)45-79-22-36-96(85,86)37-23-79/h6,8-15,38-40,43,47,53,60,66,81H,7,16-37,41-42,44-46H2,1-5H3,(H,73,83)(H,76,82)/t53-,60+,66-/m1/s1","UWAXAEFQHBGTLX-USUOEENBSA-N"
"778","P23458","JAK1","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","25.1","Inhibition of JAK1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1201.357","1200.50132649","2.11","85","9","19","2","32","239.06","C60H74F2N8O14S","InChI=1S/C60H74F2N8O14S/c1-77-55-37-42(52-38-63-51-8-2-5-44(58(51)65-52)43-35-48(61)47(49(62)36-43)39-69-19-33-85(75,76)34-20-69)9-11-54(55)84-21-4-13-67-14-16-68(17-15-67)18-22-78-23-24-79-25-26-80-27-28-81-29-30-82-31-32-83-41-57(72)64-50-7-3-6-45-46(50)40-70(60(45)74)53-10-12-56(71)66-59(53)73/h2-3,5-9,11,35-38,53H,4,10,12-34,39-41H2,1H3,(H,64,72)(H,66,71,73)","BMRKHPORRKGNAK-UHFFFAOYSA-N"
"778","O60674","JAK2","CRBN","","","COC1=CC(C2=CN=C3C=CC=C(C4=CC(F)=C(CN5CCS(=O)(=O)CC5)C(F)=C4)C3=N2)=CC=C1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.3","Inhibition of JAK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953","Inhibit IFNgamma signalling in IL2 PBMC cells","","","","","","","","","","","","","","","10.1016/j.bmc.2020.115326","1201.357","1200.50132649","2.11","85","9","19","2","32","239.06","C60H74F2N8O14S","InChI=1S/C60H74F2N8O14S/c1-77-55-37-42(52-38-63-51-8-2-5-44(58(51)65-52)43-35-48(61)47(49(62)36-43)39-69-19-33-85(75,76)34-20-69)9-11-54(55)84-21-4-13-67-14-16-68(17-15-67)18-22-78-23-24-79-25-26-80-27-28-81-29-30-82-31-32-83-41-57(72)64-50-7-3-6-45-46(50)40-70(60(45)74)53-10-12-56(71)66-59(53)73/h2-3,5-9,11,35-38,53H,4,10,12-34,39-41H2,1H3,(H,64,72)(H,66,71,73)","BMRKHPORRKGNAK-UHFFFAOYSA-N"
"779","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","132.2","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","703.756","703.275446524","1.84","52","7","8","3","9","174.26","C38H37N7O7","InChI=1S/C38H37N7O7/c1-21-34(22(2)52-42-21)24-12-13-29-26(18-24)35(23-8-5-4-6-9-23)45(38(51)43(29)3)20-33(48)39-17-16-32(47)40-28-11-7-10-25-27(28)19-44(37(25)50)30-14-15-31(46)41-36(30)49/h4-13,18,30,35H,14-17,19-20H2,1-3H3,(H,39,48)(H,40,47)(H,41,46,49)","MJFPMPXJFOVFRK-UHFFFAOYSA-N"
"780","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","138.4","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","717.783","717.291096588","2.2","53","7","8","3","10","174.26","C39H39N7O7","InChI=1S/C39H39N7O7/c1-22-35(23(2)53-43-22)25-14-15-30-27(19-25)36(24-9-5-4-6-10-24)46(39(52)44(30)3)21-34(49)40-18-8-13-32(47)41-29-12-7-11-26-28(29)20-45(38(26)51)31-16-17-33(48)42-37(31)50/h4-7,9-12,14-15,19,31,36H,8,13,16-18,20-21H2,1-3H3,(H,40,49)(H,41,47)(H,42,48,50)","GDYGHLVPTOBGTE-UHFFFAOYSA-N"
"781","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","133.6","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","731.81","731.306746652","2.56","54","7","8","3","11","174.26","C40H41N7O7","InChI=1S/C40H41N7O7/c1-23-36(24(2)54-44-23)26-15-16-31-28(20-26)37(25-10-5-4-6-11-25)47(40(53)45(31)3)22-35(50)41-19-8-7-14-33(48)42-30-13-9-12-27-29(30)21-46(39(27)52)32-17-18-34(49)43-38(32)51/h4-6,9-13,15-16,20,32,37H,7-8,14,17-19,21-22H2,1-3H3,(H,41,50)(H,42,48)(H,43,49,51)","TYSFBJXSXYPXCI-UHFFFAOYSA-N"
"782","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","99.1","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","745.837","745.322396716","2.92","55","7","8","3","12","174.26","C41H43N7O7","InChI=1S/C41H43N7O7/c1-24-37(25(2)55-45-24)27-16-17-32-29(21-27)38(26-11-6-4-7-12-26)48(41(54)46(32)3)23-36(51)42-20-9-5-8-15-34(49)43-31-14-10-13-28-30(31)22-47(40(28)53)33-18-19-35(50)44-39(33)52/h4,6-7,10-14,16-17,21,33,38H,5,8-9,15,18-20,22-23H2,1-3H3,(H,42,51)(H,43,49)(H,44,50,52)","JMBXXNDEOSNUFF-UHFFFAOYSA-N"
"783","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","80.6","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","759.864","759.33804678","3.46","56","7","8","3","13","174.26","C42H45N7O7","InChI=1S/C42H45N7O7/c1-25-38(26(2)56-46-25)28-17-18-33-30(22-28)39(27-12-7-6-8-13-27)49(42(55)47(33)3)24-37(52)43-21-10-5-4-9-16-35(50)44-32-15-11-14-29-31(32)23-48(41(29)54)34-19-20-36(51)45-40(34)53/h6-8,11-15,17-18,22,34,39H,4-5,9-10,16,19-21,23-24H2,1-3H3,(H,43,52)(H,44,50)(H,45,51,53)","UKVPRMNJZZUJHF-UHFFFAOYSA-N"
"784","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC(=O)NCCCCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","68.3","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","773.891","773.353696844","4.0","57","7","8","3","14","174.26","C43H47N7O7","InChI=1S/C43H47N7O7/c1-26-39(27(2)57-47-26)29-18-19-34-31(23-29)40(28-13-8-7-9-14-28)50(43(56)48(34)3)25-38(53)44-22-11-6-4-5-10-17-36(51)45-33-16-12-15-30-32(33)24-49(42(30)55)35-20-21-37(52)46-41(35)54/h7-9,12-16,18-19,23,35,40H,4-6,10-11,17,20-22,24-25H2,1-3H3,(H,44,53)(H,45,51)(H,46,52,54)","KOYZRJKRXJMVLY-UHFFFAOYSA-N"
"785","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","143.7","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","674.758","674.285282936","3.21","50","7","7","2","9","145.16","C38H38N6O6","InChI=1S/C38H38N6O6/c1-22-34(23(2)50-41-22)25-15-16-30-27(20-25)35(24-10-5-4-6-11-24)43(38(49)42(30)3)19-8-7-14-32(45)39-29-13-9-12-26-28(29)21-44(37(26)48)31-17-18-33(46)40-36(31)47/h4-6,9-13,15-16,20,31,35H,7-8,14,17-19,21H2,1-3H3,(H,39,45)(H,40,46,47)","NBRTWHIHNKKRKS-UHFFFAOYSA-N"
"786","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","135.1","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","688.785","688.300933","3.57","51","7","7","2","10","145.16","C39H40N6O6","InChI=1S/C39H40N6O6/c1-23-35(24(2)51-42-23)26-16-17-31-28(21-26)36(25-11-6-4-7-12-25)44(39(50)43(31)3)20-9-5-8-15-33(46)40-30-14-10-13-27-29(30)22-45(38(27)49)32-18-19-34(47)41-37(32)48/h4,6-7,10-14,16-17,21,32,36H,5,8-9,15,18-20,22H2,1-3H3,(H,40,46)(H,41,47,48)","TWEJLBFVFJIALJ-UHFFFAOYSA-N"
"787","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CCCCCCC(=O)NC1=CC=CC3=C1CN(C1CCC(=O)NC1=O)C3=O)C(=O)N2C","","","","","","118.2","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","702.812","702.316583064","4.11","52","7","7","2","11","145.16","C40H42N6O6","InChI=1S/C40H42N6O6/c1-24-36(25(2)52-43-24)27-17-18-32-29(22-27)37(26-12-7-6-8-13-26)45(40(51)44(32)3)21-10-5-4-9-16-34(47)41-31-15-11-14-28-30(31)23-46(39(28)50)33-19-20-35(48)42-38(33)49/h6-8,11-15,17-18,22,33,37H,4-5,9-10,16,19-21,23H2,1-3H3,(H,41,47)(H,42,48,49)","WWNICNOCLLDQAH-UHFFFAOYSA-N"
"788","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","14.2","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1830","Inhibit proliferation of THP-1 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","757.808","757.297244588","1.68","56","8","11","2","11","185.1","C40H39N9O7","InChI=1S/C40H39N9O7/c1-23-36(24(2)56-44-23)26-12-13-32-29(18-26)37(25-8-5-4-6-9-25)49(40(54)46(32)3)20-27-19-47(45-43-27)16-17-55-22-35(51)41-31-11-7-10-28-30(31)21-48(39(28)53)33-14-15-34(50)42-38(33)52/h4-13,18-19,33,37H,14-17,20-22H2,1-3H3,(H,41,51)(H,42,50,52)","LSXNGBATZZFCNR-UHFFFAOYSA-N"
"789","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","15.4","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","801.861","801.323459336","1.53","59","8","12","2","14","194.33","C42H43N9O8","InChI=1S/C42H43N9O8/c1-25-38(26(2)59-46-25)28-12-13-34-31(20-28)39(27-8-5-4-6-9-27)51(42(56)48(34)3)22-29-21-49(47-45-29)16-17-57-18-19-58-24-37(53)43-33-11-7-10-30-32(33)23-50(41(30)55)35-14-15-36(52)44-40(35)54/h4-13,20-21,35,39H,14-19,22-24H2,1-3H3,(H,43,53)(H,44,52,54)","BCNGPHRTMULQMG-UHFFFAOYSA-N"
"790","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","22.1","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","845.914","845.349674084","1.38","62","8","13","2","17","203.56","C44H47N9O9","InChI=1S/C44H47N9O9/c1-27-40(28(2)62-48-27)30-12-13-36-33(22-30)41(29-8-5-4-6-9-29)53(44(58)50(36)3)24-31-23-51(49-47-31)16-17-59-18-19-60-20-21-61-26-39(55)45-35-11-7-10-32-34(35)25-52(43(32)57)37-14-15-38(54)46-42(37)56/h4-13,22-23,37,41H,14-21,24-26H2,1-3H3,(H,45,55)(H,46,54,56)","XCJDHBIXDKXDJW-UHFFFAOYSA-N"
"791","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","22.6","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","889.967","889.375888832","1.24","65","8","14","2","20","212.79","C46H51N9O10","InChI=1S/C46H51N9O10/c1-29-42(30(2)65-50-29)32-12-13-38-35(24-32)43(31-8-5-4-6-9-31)55(46(60)52(38)3)26-33-25-53(51-49-33)16-17-61-18-19-62-20-21-63-22-23-64-28-41(57)47-37-11-7-10-34-36(37)27-54(45(34)59)39-14-15-40(56)48-44(39)58/h4-13,24-25,39,43H,14-23,26-28H2,1-3H3,(H,47,57)(H,48,56,58)","RBXLLHZMKFTUMG-UHFFFAOYSA-N"
"792","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","41.8","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","810","Inhibit proliferation of THP-1 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","771.791","771.276509144","2.17","57","8","12","2","11","202.17","C40H37N9O8","InChI=1S/C40H37N9O8/c1-22-34(23(2)57-44-22)25-12-13-30-28(18-25)36(24-8-5-4-6-9-24)48(40(55)46(30)3)20-26-19-47(45-43-26)16-17-56-21-33(51)41-29-11-7-10-27-35(29)39(54)49(38(27)53)31-14-15-32(50)42-37(31)52/h4-13,18-19,31,36H,14-17,20-21H2,1-3H3,(H,41,51)(H,42,50,52)","FXNACIMQXOPNJG-UHFFFAOYSA-N"
"793","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","67.7","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1660","Inhibit proliferation of THP-1 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","815.844","815.302723892","2.03","60","8","13","2","14","211.4","C42H41N9O9","InChI=1S/C42H41N9O9/c1-24-36(25(2)60-46-24)27-12-13-32-30(20-27)38(26-8-5-4-6-9-26)50(42(57)48(32)3)22-28-21-49(47-45-28)16-17-58-18-19-59-23-35(53)43-31-11-7-10-29-37(31)41(56)51(40(29)55)33-14-15-34(52)44-39(33)54/h4-13,20-21,33,38H,14-19,22-23H2,1-3H3,(H,43,53)(H,44,52,54)","IBSSKCQUALKIGL-UHFFFAOYSA-N"
"794","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","68.5","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1750","Inhibit proliferation of THP-1 cells","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","859.897","859.32893864","1.88","63","8","14","2","17","220.63","C44H45N9O10","InChI=1S/C44H45N9O10/c1-26-38(27(2)63-48-26)29-12-13-34-32(22-29)40(28-8-5-4-6-9-28)52(44(59)50(34)3)24-30-23-51(49-47-30)16-17-60-18-19-61-20-21-62-25-37(55)45-33-11-7-10-31-39(33)43(58)53(42(31)57)35-14-15-36(54)46-41(35)56/h4-13,22-23,35,40H,14-21,24-25H2,1-3H3,(H,45,55)(H,46,54,56)","SREGPLSSQYMUCF-UHFFFAOYSA-N"
"795","O60885","BRD4","CRBN","","","CC1=NOC(C)=C1C1=CC=C2C(=C1)C(C1=CC=CC=C1)N(CC1=CN(CCOCCOCCOCCOCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)C(=O)N2C","","","","","","173.4","Inhibition of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.115228","903.95","903.355153388","1.73","66","8","15","2","20","229.86","C46H49N9O11","InChI=1S/C46H49N9O11/c1-28-40(29(2)66-50-28)31-12-13-36-34(24-31)42(30-8-5-4-6-9-30)54(46(61)52(36)3)26-32-25-53(51-49-32)16-17-62-18-19-63-20-21-64-22-23-65-27-39(57)47-35-11-7-10-33-41(35)45(60)55(44(33)59)37-14-15-38(56)48-43(37)58/h4-13,24-25,37,42H,14-23,26-27H2,1-3H3,(H,47,57)(H,48,56,58)","IIPBIAUPRRJSTH-UHFFFAOYSA-N"
"796","Q86U86","PBRM1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOCCOCCN3CCN(C4=CC(C5=CC=CC=C5O)=NN=C4N)CC3)=C2)SC=N1","","","","","","1500","IC50 of PBRM1 BD5 was tested by TR-FRET","","","2700","SPR in PBRM1 BD5","","","","","","","","","","","","","","","234/98","ITC/SPR","210","FP","-37.9","-21","-17","ITC","","","","","220","TR-FRET","","","","","79","FP","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","918.106","917.4269591","3.22","65","7","15","5","19","217.83","C46H60FN9O8S","InChI=1S/C46H60FN9O8S/c1-29-39(65-28-50-29)30-9-10-31(26-49-42(59)36-24-32(57)27-56(36)43(60)40(45(2,3)4)51-44(61)46(47)11-12-46)38(23-30)64-22-21-63-20-19-62-18-17-54-13-15-55(16-14-54)35-25-34(52-53-41(35)48)33-7-5-6-8-37(33)58/h5-10,23,25,28,32,36,40,57-58H,11-22,24,26-27H2,1-4H3,(H2,48,53)(H,49,59)(H,51,61)/t32-,36+,40-/m1/s1","QCULBRPVCWJUKY-OUMVKTTMSA-N"
"796","P51531","SMARCA2","VHL","6HAY","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOCCOCCN3CCN(C4=CC(C5=CC=CC=C5O)=NN=C4N)CC3)=C2)SC=N1","300","65","Degradation of SMARCA2 in MV-4-11 cells after 18 h treatment","","","2400/600","IC50 of SMARCA2 BD was tested by TR-FRET/AlphaLISA","","","4500","SPR in SMARCA2 BD","","","","","","","","","","","","","","","234/98","ITC/SPR","210","FP","-37.9","-21","-17","ITC","","","","","205/120","TR-FRET/AlphaLISA","","","49","ITC","48","FP","-41.8","-27","-15","ITC between VHL and PROTAC:SMARCA2","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","918.106","917.4269591","3.22","65","7","15","5","19","217.83","C46H60FN9O8S","InChI=1S/C46H60FN9O8S/c1-29-39(65-28-50-29)30-9-10-31(26-49-42(59)36-24-32(57)27-56(36)43(60)40(45(2,3)4)51-44(61)46(47)11-12-46)38(23-30)64-22-21-63-20-19-62-18-17-54-13-15-55(16-14-54)35-25-34(52-53-41(35)48)33-7-5-6-8-37(33)58/h5-10,23,25,28,32,36,40,57-58H,11-22,24,26-27H2,1-4H3,(H2,48,53)(H,49,59)(H,51,61)/t32-,36+,40-/m1/s1","QCULBRPVCWJUKY-OUMVKTTMSA-N"
"796","P51532","SMARCA4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOCCOCCN3CCN(C4=CC(C5=CC=CC=C5O)=NN=C4N)CC3)=C2)SC=N1","250","70","Degradation of SMARCA4 in MV-4-11 cells after 18 h treatment","","","3000/1300","IC50 of SMARCA4 BD was tested by TR-FRET/AlphaLISA","","","4800","SPR in SMARCA4 BD","","","","","","","","","","","","","","","234/98","ITC/SPR","210","FP","-37.9","-21","-17","ITC","","","","","230/330","TR-FRET/AlphaLISA","","","","","26","FP","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","918.106","917.4269591","3.22","65","7","15","5","19","217.83","C46H60FN9O8S","InChI=1S/C46H60FN9O8S/c1-29-39(65-28-50-29)30-9-10-31(26-49-42(59)36-24-32(57)27-56(36)43(60)40(45(2,3)4)51-44(61)46(47)11-12-46)38(23-30)64-22-21-63-20-19-62-18-17-54-13-15-55(16-14-54)35-25-34(52-53-41(35)48)33-7-5-6-8-37(33)58/h5-10,23,25,28,32,36,40,57-58H,11-22,24,26-27H2,1-4H3,(H2,48,53)(H,49,59)(H,51,61)/t32-,36+,40-/m1/s1","QCULBRPVCWJUKY-OUMVKTTMSA-N"
"797","Q86U86","PBRM1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","","","","","","550","IC50 of PBRM1 BD5 was tested by TR-FRET","","","570","SPR in PBRM1 BD5","","","","","","","","","","","","","","","100","SPR","490","FP","","","","","","","","","28","TR-FRET","","","","","19","FP","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","920.125","919.421479796","5.27","66","8","13","5","15","199.37","C49H58FN9O6S","InChI=1S/C49H58FN9O6S/c1-30-42(66-29-53-30)33-13-14-34(26-52-45(62)39-24-35(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)16-17-49)41(23-33)65-22-15-31-9-11-32(12-10-31)27-57-18-20-58(21-19-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,35,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t35-,39+,43-/m1/s1","UTZVLJZPTDCKCT-XBPZXCMESA-N"
"797","P51531","SMARCA2","VHL","6HAX","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","","","","","","790/680","IC50 of SMARCA2 BD was tested by TR-FRET/AlphaLISA","","","770","SPR in SMARCA2 BD","","","","","","","","","","","","","","","100","SPR","490","FP","","","","","","","","","45/120","TR-FRET/AlphaLISA","","","","","26","FP","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","920.125","919.421479796","5.27","66","8","13","5","15","199.37","C49H58FN9O6S","InChI=1S/C49H58FN9O6S/c1-30-42(66-29-53-30)33-13-14-34(26-52-45(62)39-24-35(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)16-17-49)41(23-33)65-22-15-31-9-11-32(12-10-31)27-57-18-20-58(21-19-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,35,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t35-,39+,43-/m1/s1","UTZVLJZPTDCKCT-XBPZXCMESA-N"
"797","P51532","SMARCA4","VHL","6HR2","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","","","","","","990/960","IC50 of SMARCA4 BD was tested by TR-FRET/AlphaLISA","","","1030","SPR in SMARCA4 BD","","","","","","","","","","","","","","","100","SPR","490","FP","","","","","","","","","76/240","TR-FRET/AlphaLISA","","","","","14","FP","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","920.125","919.421479796","5.27","66","8","13","5","15","199.37","C49H58FN9O6S","InChI=1S/C49H58FN9O6S/c1-30-42(66-29-53-30)33-13-14-34(26-52-45(62)39-24-35(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)16-17-49)41(23-33)65-22-15-31-9-11-32(12-10-31)27-57-18-20-58(21-19-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,35,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t35-,39+,43-/m1/s1","UTZVLJZPTDCKCT-XBPZXCMESA-N"
"798","P51531","SMARCA2","VHL","","ACBI1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","6/3.3","","Degradation of SMARCA2 in MV-4-11/NCI-H1568 cells after 18 h treatment","","","770/700","IC50 of SMARCA2 BD was tested by TR-FRET/AlphaLISA","","","1800","SPR in SMARCA2 BD","","","","","","","","","","","","","","","250","SPR","450","FP","","","","","","","","","26/730","TR-FRET/AlphaLISA","","","","","16","FP","","","","","","","","","28/68","Inhibit proliferation of MV-4-11/NCI-H1568 cells","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","936.124","935.416394416","4.98","67","8","14","5","16","208.6","C49H58FN9O7S","InChI=1S/C49H58FN9O7S/c1-30-42(67-29-53-30)32-11-12-33(26-52-45(62)39-24-34(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)15-16-49)41(23-32)66-22-21-65-35-13-9-31(10-14-35)27-57-17-19-58(20-18-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,34,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t34-,39+,43-/m1/s1","IVARZBJJMMUJHI-SQKKEFIPSA-N"
"798","P51532","SMARCA4","VHL","","ACBI1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","11","","Degradation of SMARCA2 in MV-4-11 cells after 18 h treatment","","","560/670","IC50 of SMARCA4 BD was tested by TR-FRET/AlphaLISA","","","2600","SPR in SMARCA4 BD","","","","","","","","","","","","","","","250","SPR","450","FP","","","","","","","","","51/720","TR-FRET/AlphaLISA","","","","","","","","","","","","","","","28/68","Inhibit proliferation of MV-4-11/NCI-H1568 cells","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","936.124","935.416394416","4.98","67","8","14","5","16","208.6","C49H58FN9O7S","InChI=1S/C49H58FN9O7S/c1-30-42(67-29-53-30)32-11-12-33(26-52-45(62)39-24-34(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)15-16-49)41(23-32)66-22-21-65-35-13-9-31(10-14-35)27-57-17-19-58(20-18-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,34,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t34-,39+,43-/m1/s1","IVARZBJJMMUJHI-SQKKEFIPSA-N"
"798","Q86U86","PBRM1","VHL","","ACBI1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","32/15.6","","Degradation of PBRM1 in MV-4-11/NCI-H1568 cells after 18 h treatment","","","504","IC50 of PBRM1 BD5 was tested by TR-FRET","","","830","SPR in PBRM1 BD5","","","","","","","","","","","","","","","250","SPR","450","FP","","","","","","","","","42","TR-FRET","","","","","","","","","","","","","","","28/68","Inhibit proliferation of MV-4-11/NCI-H1568 cells","","","","","","","","","","","","","","","10.1038/s41589-019-0294-6","936.124","935.416394416","4.98","67","8","14","5","16","208.6","C49H58FN9O7S","InChI=1S/C49H58FN9O7S/c1-30-42(67-29-53-30)32-11-12-33(26-52-45(62)39-24-34(60)28-59(39)46(63)43(48(2,3)4)54-47(64)49(50)15-16-49)41(23-32)66-22-21-65-35-13-9-31(10-14-35)27-57-17-19-58(20-18-57)38-25-37(55-56-44(38)51)36-7-5-6-8-40(36)61/h5-14,23,25,29,34,39,43,60-61H,15-22,24,26-28H2,1-4H3,(H2,51,56)(H,52,62)(H,54,64)/t34-,39+,43-/m1/s1","IVARZBJJMMUJHI-SQKKEFIPSA-N"
"799","P50750","CDK9","CRBN","","THAL-SNS-032","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCN(CC(=O)NCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)S2)O1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50/124.4/92.5","Inhibit proliferation of MOLT4/Jurkat/MOLT 16 cells","","","","","","","","","","","","","","","10.1038/nchembio.2538","869.036","868.324781864","2.79","60","6","16","4","21","223.63","C40H52N8O10S2","InChI=1S/C40H52N8O10S2/c1-40(2,3)29-21-43-32(58-29)24-59-33-22-44-39(60-33)46-35(51)25-9-13-47(14-10-25)23-31(50)42-12-16-56-18-20-57-19-17-55-15-11-41-27-6-4-5-26-34(27)38(54)48(37(26)53)28-7-8-30(49)45-36(28)52/h4-6,21-22,25,28,41H,7-20,23-24H2,1-3H3,(H,42,50)(H,44,46,51)(H,45,49,52)","BXDZOYLPNAIDOC-UHFFFAOYSA-N"
"800","P50750","CDK9","CRBN","","THAL-NVP-2-02-099","N#CC1(CNC2=CC=CC(C3=CC(N[C@H]4CC[C@H](NCC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=NC=C3Cl)=N2)CCOCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2538","929.476","928.399851084","3.39","66","7","16","6","23","247.26","C46H57ClN10O9","InChI=1S/C46H57ClN10O9/c47-34-26-52-39(25-33(34)35-4-2-6-38(55-35)53-29-46(28-48)13-17-63-18-14-46)54-31-9-7-30(8-10-31)51-27-41(59)50-16-20-65-22-24-66-23-21-64-19-15-49-36-5-1-3-32-42(36)45(62)57(44(32)61)37-11-12-40(58)56-43(37)60/h1-6,25-26,30-31,37,49,51H,7-24,27,29H2,(H,50,59)(H,52,54)(H,53,55)(H,56,58,60)/t30-,31-,37?","JNHULBNMCUQKGV-JZSUORBJSA-N"
"801","P50750","CDK9","CRBN","","THAL-NVP-2-03-069","N#CC1(CNC2=CC=CC(C3=CC(N[C@H]4CC[C@H](NCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=NC=C3Cl)=N2)CCOCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2538","796.373","795.36234338","5.91","57","7","12","5","16","190.47","C42H50ClN9O5","InChI=1S/C42H50ClN9O5/c43-31-24-47-36(23-30(31)32-8-6-10-35(50-32)48-26-42(25-44)17-21-57-22-18-42)49-28-13-11-27(12-14-28)45-19-3-1-2-4-20-46-33-9-5-7-29-38(33)41(56)52(40(29)55)34-15-16-37(53)51-39(34)54/h5-10,23-24,27-28,34,45-46H,1-4,11-22,26H2,(H,47,49)(H,48,50)(H,51,53,54)/t27-,28-,34?","CPSSESFSJBNGIE-FTJNFWDJSA-N"
"802","P50750","CDK9","CRBN","","THAL-NVP-2-03-084","N#CC1(CNC2=CC=CC(C3=CC(N[C@H]4CC[C@H](NCCCCCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=NC=C3Cl)=N2)CCOCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2538","853.425","852.383807096","5.26","61","7","13","6","18","219.57","C44H53ClN10O6","InChI=1S/C44H53ClN10O6/c45-32-24-50-37(23-31(32)33-8-6-10-36(53-33)51-27-44(26-46)17-21-61-22-18-44)52-29-13-11-28(12-14-29)47-19-3-1-2-4-20-48-39(57)25-49-34-9-5-7-30-40(34)43(60)55(42(30)59)35-15-16-38(56)54-41(35)58/h5-10,23-24,28-29,35,47,49H,1-4,11-22,25,27H2,(H,48,57)(H,50,52)(H,51,53)(H,54,56,58)/t28-,29-,35?","GKWDSIRGBSJWQV-WIYXFFCHSA-N"
"803","P50750","CDK9","CRBN","","THAL-NVP-2-03-105","N#CC1(CNC2=CC=CC(C3=CC(N[C@H]4CC[C@H](NCCCC(=O)NCCCCOC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)=NC=C3Cl)=N2)CCOCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/nchembio.2538","854.409","853.367822684","4.24","61","7","13","5","18","216.77","C44H52ClN9O7","InChI=1S/C44H52ClN9O7/c45-34-25-49-38(24-33(34)35-5-3-6-37(52-35)50-27-44(26-46)16-21-60-22-17-44)51-29-10-8-28(9-11-29)47-19-4-7-39(55)48-18-1-2-20-61-30-12-13-31-32(23-30)43(59)54(42(31)58)36-14-15-40(56)53-41(36)57/h3,5-6,12-13,23-25,28-29,36,47H,1-2,4,7-11,14-22,27H2,(H,48,55)(H,49,51)(H,50,52)(H,53,56,57)/t28-,29-,36?","YIUYYYKRKXRMJK-ARBFJVLTSA-N"
"804","P62942","FKBP12","DCAF16","","KB02-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)CCOCCOCCNC(=O)COC2=CC=C3C(=C2)CCCN3C(=O)CCl)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14000","Inhibit viability of HEK293T cells","","","","","","","","","","","","","","","10.1038/s41589-019-0279-5","949.539","948.4287512","6.15","67","5","12","2","25","188.34","C50H65ClN4O12","InChI=1S/C50H65ClN4O12/c1-6-50(2,3)47(59)48(60)55-23-8-7-14-40(55)49(61)67-41(19-15-34-16-20-42(62-4)43(29-34)63-5)36-11-9-13-37(30-36)53-44(56)21-25-64-27-28-65-26-22-52-45(57)33-66-38-17-18-39-35(31-38)12-10-24-54(39)46(58)32-51/h9,11,13,16-18,20,29-31,40-41H,6-8,10,12,14-15,19,21-28,32-33H2,1-5H3,(H,52,57)(H,53,56)/t40-,41+/m0/s1","OKJBKEQXKMMRPL-WVILEFPPSA-N"
"805","P62942","FKBP12","CRBN","","Lenalidomide-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)CCCC(=O)NCCCCC(=O)NC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0279-5","979.141","978.473871552","4.44","71","6","12","4","23","235.92","C53H66N6O12","InChI=1S/C53H66N6O12/c1-6-53(2,3)48(64)51(67)58-29-10-8-18-40(58)52(68)71-41(25-22-33-23-26-42(69-4)43(30-33)70-5)34-14-11-15-35(31-34)55-45(61)21-13-20-44(60)54-28-9-7-19-46(62)56-38-17-12-16-36-37(38)32-59(50(36)66)39-24-27-47(63)57-49(39)65/h11-12,14-17,23,26,30-31,39-41H,6-10,13,18-22,24-25,27-29,32H2,1-5H3,(H,54,60)(H,55,61)(H,56,62)(H,57,63,65)/t39?,40-,41+/m0/s1","KDFHLYOEKZBLNX-XRCKYFATSA-N"
"806","P62942","FKBP12","DCAF16","","KB02-PEG0-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)COC2=CC=C3C(=C2)CCCN3C(=O)CCl)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0279-5","790.354","789.339207924","7.2","56","5","9","1","16","140.78","C43H52ClN3O9","InChI=1S/C43H52ClN3O9/c1-6-43(2,3)40(50)41(51)47-21-8-7-14-34(47)42(52)56-35(19-15-28-16-20-36(53-4)37(23-28)54-5)30-11-9-13-31(24-30)45-38(48)27-55-32-17-18-33-29(25-32)12-10-22-46(33)39(49)26-44/h9,11,13,16-18,20,23-25,34-35H,6-8,10,12,14-15,19,21-22,26-27H2,1-5H3,(H,45,48)/t34-,35+/m0/s1","YCLKEPYZVKTUTQ-OIDHKYIRSA-N"
"807","P62942","FKBP12","DCAF16","","KB02-PEG4-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(NC(=O)CCOCCOCCOCCOCCNC(=O)COC2=CC=C3C(=C2)CCCN3C(=O)CCl)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0279-5","1037.645","1036.4811807","5.85","73","5","14","2","31","206.8","C54H73ClN4O14","InChI=1S/C54H73ClN4O14/c1-6-54(2,3)51(63)52(64)59-23-8-7-14-44(59)53(65)73-45(19-15-38-16-20-46(66-4)47(33-38)67-5)40-11-9-13-41(34-40)57-48(60)21-25-68-27-29-70-31-32-71-30-28-69-26-22-56-49(61)37-72-42-17-18-43-39(35-42)12-10-24-58(43)50(62)36-55/h9,11,13,16-18,20,33-35,44-45H,6-8,10,12,14-15,19,21-32,36-37H2,1-5H3,(H,56,61)(H,57,60)/t44-,45+/m0/s1","OJKIBQIBTOZPAI-YWPUXERESA-N"
"808","O60885","BRD4","DCAF16","","KB02-JQ1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCNC(=O)COC1=CC=C3C(=C1)CCCN3C(=O)CCl)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">50000","Inhibit viability of HEK293T cells","","","","","","","","","","","","","","","10.1038/s41589-019-0279-5","796.778","795.237258456","4.38","54","6","11","2","16","149.27","C38H43Cl2N7O6S","InChI=1S/C38H43Cl2N7O6S/c1-23-24(2)54-38-35(23)36(26-6-8-28(40)9-7-26)43-30(37-45-44-25(3)47(37)38)20-32(48)41-12-15-51-17-18-52-16-13-42-33(49)22-53-29-10-11-31-27(19-29)5-4-14-46(31)34(50)21-39/h6-11,19,30H,4-5,12-18,20-22H2,1-3H3,(H,41,48)(H,42,49)/t30-/m0/s1","XIYYDTXOEVAZGI-PMERELPUSA-N"
"809","Q9NWZ3","IRAK4","VHL","","","COC1=CC2=C(OC[C@@H]3CCC(=O)N3)N=CC(C#CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=C2C=C1C(N)=O","","N.D.","","","","0.29","Inhibition of IRAK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","942.105","941.399326708","2.47","67","6","14","5","21","242.86","C48H59N7O11S","InChI=1S/C48H59N7O11S/c1-29-42(67-28-52-29)31-10-8-30(9-11-31)24-50-45(60)38-21-34(56)26-55(38)47(61)43(48(2,3)4)54-41(58)14-16-64-18-20-65-19-17-63-15-6-7-32-25-51-46(66-27-33-12-13-40(57)53-33)36-23-39(62-5)37(44(49)59)22-35(32)36/h8-11,22-23,25,28,33-34,38,43,56H,12-21,24,26-27H2,1-5H3,(H2,49,59)(H,50,60)(H,53,57)(H,54,58)/t33-,34+,38-,43+/m0/s1","HEUMLQGYGXEOHM-UPOJZSHJSA-N"
"810","Q9NWZ3","IRAK4","VHL","","","COC1=CC2=C(OC[C@@H]3CCC(=O)N3)N=CC(C#CCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=C2C=C1C(N)=O","","50","Degradation of IRAK4 in PBMC cells after 24 h treatment","","","0.099","Inhibition of IRAK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","936.189","935.46153304","7.52","67","6","11","5","21","215.17","C51H65N7O8S","InChI=1S/C51H65N7O8S/c1-32-45(67-31-55-32)34-20-18-33(19-21-34)27-53-48(63)41-24-37(59)29-58(41)50(64)46(51(2,3)4)57-43(60)17-15-13-11-9-7-6-8-10-12-14-16-35-28-54-49(66-30-36-22-23-44(61)56-36)39-26-42(65-5)40(47(52)62)25-38(35)39/h18-21,25-26,28,31,36-37,41,46,59H,6-13,15,17,22-24,27,29-30H2,1-5H3,(H2,52,62)(H,53,63)(H,56,61)(H,57,60)/t36-,37+,41-,46+/m0/s1","DFCKZXBDTTURLE-ABFWCBLXSA-N"
"811","Q9NWZ3","IRAK4","CRBN","","","COC1=CC2=C(OC[C@@H]3CCC(=O)N3)N=CC(C#CCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2C=C1C(N)=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","757.753","757.259521688","0.32","55","6","13","3","17","224.01","C38H39N5O12","InChI=1S/C38H39N5O12/c1-50-30-19-26-25(18-27(30)34(39)46)22(20-40-36(26)55-21-23-7-9-31(44)41-23)4-3-11-51-12-13-52-14-15-53-16-17-54-29-6-2-5-24-33(29)38(49)43(37(24)48)28-8-10-32(45)42-35(28)47/h2,5-6,18-20,23,28H,7-17,21H2,1H3,(H2,39,46)(H,41,44)(H,42,45,47)/t23-,28?/m0/s1","NPHNFTBWNSEKQR-UHFKCPIBSA-N"
"812","Q9NWZ3","IRAK4","CRBN","","","COC1=CC2=C(OC[C@@H]3CCC(=O)N3)N=CC(C#CCCCCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2C=C1C(N)=O","","N.D.","","","","2.5","Inhibition of IRAK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","751.837","751.32172802","5.19","55","6","10","3","17","196.32","C41H45N5O9","InChI=1S/C41H45N5O9/c1-53-33-22-29-28(21-30(33)37(42)49)25(23-43-39(29)55-24-26-16-18-34(47)44-26)13-10-8-6-4-2-3-5-7-9-11-20-54-32-15-12-14-27-36(32)41(52)46(40(27)51)31-17-19-35(48)45-38(31)50/h12,14-15,21-23,26,31H,2-9,11,16-20,24H2,1H3,(H2,42,49)(H,44,47)(H,45,48,50)/t26-,31?/m0/s1","POTNHTDKTOIKCT-PAMMARIWSA-N"
"813","Q9NWZ3","IRAK4","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCC#CC2=CN=C(OC[C@@H]3CCC(=O)N3)C3=CC(OC)=C(C(N)=O)C=C23)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","N.D.","","","","0.022","Inhibition of IRAK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","995.188","994.51640506","2.8","72","7","13","6","23","250.87","C53H70N8O11","InChI=1S/C53H70N8O11/c1-33(55-2)50(65)60-48(35-12-5-4-6-13-35)53(67)61-31-38(27-44(61)51(66)59-43-17-9-14-34-11-7-8-16-39(34)43)58-47(63)20-22-70-24-26-71-25-23-69-21-10-15-36-30-56-52(72-32-37-18-19-46(62)57-37)41-29-45(68-3)42(49(54)64)28-40(36)41/h7-8,11,16,28-30,33,35,37-38,43-44,48,55H,4-6,9,12-14,17-27,31-32H2,1-3H3,(H2,54,64)(H,57,62)(H,58,63)(H,59,66)(H,60,65)/t33-,37-,38-,43+,44-,48-/m0/s1","OGZACTPFSVITBX-IHPDELBNSA-N"
"814","Q9NWZ3","IRAK4","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCCC#CC2=CN=C(OC[C@@H]3CCC(=O)N3)C3=CC(OC)=C(C(N)=O)C=C23)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","N.D.","","","","21","Inhibition of IRAK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","989.272","988.578611392","7.86","72","7","10","6","23","223.18","C56H76N8O8","InChI=1S/C56H76N8O8/c1-36(58-2)53(68)63-51(38-21-14-12-15-22-38)56(70)64-34-41(30-47(64)54(69)62-46-26-19-24-37-20-17-18-25-42(37)46)61-49(65)27-16-11-9-7-5-4-6-8-10-13-23-39-33-59-55(72-35-40-28-29-50(66)60-40)44-32-48(71-3)45(52(57)67)31-43(39)44/h17-18,20,25,31-33,36,38,40-41,46-47,51,58H,4-12,14-16,19,21-22,24,26-30,34-35H2,1-3H3,(H2,57,67)(H,60,66)(H,61,65)(H,62,69)(H,63,68)/t36-,40-,41-,46+,47-,51-/m0/s1","CVFKSFVSLDSCBQ-ROZMQCGGSA-N"
"815","Q9NWZ3","IRAK4","VHL","","","CC[C@H]1[C@@H](COC2=NC=C(C#CCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C3=CC(C(N)=O)=C(OC)C=C23)NC(=O)[C@H]1F","259","","Degradation of IRAK4 in PBMC cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","982.233","981.483411356","8.79","70","6","11","5","22","215.17","C53H68FN7O8S","InChI=1S/C53H68FN7O8S/c1-7-37-41(59-50(66)45(37)54)30-69-51-39-26-43(68-6)40(48(55)64)25-38(39)35(28-57-51)18-16-14-12-10-8-9-11-13-15-17-19-44(63)60-47(53(3,4)5)52(67)61-29-36(62)24-42(61)49(65)56-27-33-20-22-34(23-21-33)46-32(2)58-31-70-46/h20-23,25-26,28,31,36-37,41-42,45,47,62H,7-15,17,19,24,27,29-30H2,1-6H3,(H2,55,64)(H,56,65)(H,59,66)(H,60,63)/t36-,37+,41-,42+,45+,47-/m1/s1","OMTXYNZVPBTRTI-LWWCJIENSA-N"
"816","Q9NWZ3","IRAK4","VHL","","","CC[C@H]1[C@@H](COC2=NC=C(C#CCN3CCC4(CC3)CCN(C3=NC=C(C(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=N3)CC4)C3=CC(C(N)=O)=C(OC)C=C23)NC(=O)[C@H]1F","151/36","","Degradation of IRAK4 in PBMC cells/dermal fibroblast after 24/24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00219","1086.305","1085.49570736","5.77","78","9","15","5","15","247.43","C57H68FN11O8S","InChI=1S/C57H68FN11O8S/c1-7-39-43(65-52(74)46(39)58)31-77-53-41-25-45(76-6)42(49(59)71)24-40(41)36(27-61-53)9-8-18-67-19-14-57(15-20-67)16-21-68(22-17-57)55-62-28-37(29-63-55)50(72)66-48(56(3,4)5)54(75)69-30-38(70)23-44(69)51(73)60-26-34-10-12-35(13-11-34)47-33(2)64-32-78-47/h10-13,24-25,27-29,32,38-39,43-44,46,48,70H,7,14-23,26,30-31H2,1-6H3,(H2,59,71)(H,60,73)(H,65,74)(H,66,72)/t38-,39+,43-,44+,46+,48-/m1/s1","VCCDOPPWOSIMCD-LLCFZETMSA-N"
"817","P53350","PLK1","CRBN","","HBL-4","CC[C@@H]1C(=O)N(C)C2=CN=C(NC3=CC=C(C(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3OC)N=C2N1C1CCCC1","10-20","","Degradation of PLK1 in MV4-11 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.48/6.21/6.94","Inhibit viability of MV4-11/MOLM-13/KG1 cells","","","","","","","","","","","","","","","10.1016/j.bbrc.2019.11.007","811.897","811.365324148","3.28","59","7","14","4","17","213.73","C41H49N9O9","InChI=1S/C41H49N9O9/c1-4-29-39(55)48(2)31-23-44-41(47-35(31)49(29)25-8-5-6-9-25)45-27-13-12-24(22-32(27)57-3)36(52)43-17-19-59-21-20-58-18-16-42-28-11-7-10-26-34(28)40(56)50(38(26)54)30-14-15-33(51)46-37(30)53/h7,10-13,22-23,25,29-30,42H,4-6,8-9,14-21H2,1-3H3,(H,43,52)(H,44,45,47)(H,46,51,53)/t29-,30?/m1/s1","QSDZWQSDYJSGFC-IDCGIGBZSA-N"
"817","O60885","BRD4","CRBN","","HBL-4","CC[C@@H]1C(=O)N(C)C2=CN=C(NC3=CC=C(C(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3OC)N=C2N1C1CCCC1","<5","","Degradation of BRD4 in MV4-11 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.48/6.21/6.94","Inhibit viability of MV4-11/MOLM-13/KG1 cells","","","","","","","","","","","","","","","10.1016/j.bbrc.2019.11.007","811.897","811.365324148","3.28","59","7","14","4","17","213.73","C41H49N9O9","InChI=1S/C41H49N9O9/c1-4-29-39(55)48(2)31-23-44-41(47-35(31)49(29)25-8-5-6-9-25)45-27-13-12-24(22-32(27)57-3)36(52)43-17-19-59-21-20-58-18-16-42-28-11-7-10-26-34(28)40(56)50(38(26)54)30-14-15-33(51)46-37(30)53/h7,10-13,22-23,25,29-30,42H,4-6,8-9,14-21H2,1-3H3,(H,43,52)(H,44,45,47)(H,46,51,53)/t29-,30?/m1/s1","QSDZWQSDYJSGFC-IDCGIGBZSA-N"
"818","O60885","BRD4","CRBN","","HBL-5","CC[C@@H]1C(=O)N(C)C2=CN=C(NC3=CC=C(C(=O)NCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3OC)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.38","Inhibit viability of MV4-11 cells","","","","","","","","","","","","","","","10.1016/j.bbrc.2019.11.007","900.003","899.417753644","2.99","65","7","16","4","23","232.19","C45H57N9O11","InChI=1S/C45H57N9O11/c1-4-33-43(59)52(2)35-27-48-45(51-39(35)53(33)29-8-5-6-9-29)49-31-13-12-28(26-36(31)61-3)40(56)47-17-19-63-21-23-65-25-24-64-22-20-62-18-16-46-32-11-7-10-30-38(32)44(60)54(42(30)58)34-14-15-37(55)50-41(34)57/h7,10-13,26-27,29,33-34,46H,4-6,8-9,14-25H2,1-3H3,(H,47,56)(H,48,49,51)(H,50,55,57)/t33-,34?/m1/s1","GLNZQWXKBMEKNA-BONSOQDYSA-N"
"818","P53350","PLK1","CRBN","","HBL-5","CC[C@@H]1C(=O)N(C)C2=CN=C(NC3=CC=C(C(=O)NCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3OC)N=C2N1C1CCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.38","Inhibit viability of MV4-11 cells","","","","","","","","","","","","","","","10.1016/j.bbrc.2019.11.007","900.003","899.417753644","2.99","65","7","16","4","23","232.19","C45H57N9O11","InChI=1S/C45H57N9O11/c1-4-33-43(59)52(2)35-27-48-45(51-39(35)53(33)29-8-5-6-9-29)49-31-13-12-28(26-36(31)61-3)40(56)47-17-19-63-21-23-65-25-24-64-22-20-62-18-16-46-32-11-7-10-30-38(32)44(60)54(42(30)58)34-14-15-37(55)50-41(34)57/h7,10-13,26-27,29,33-34,46H,4-6,8-9,14-25H2,1-3H3,(H,47,56)(H,48,49,51)(H,50,55,57)/t33-,34?/m1/s1","GLNZQWXKBMEKNA-BONSOQDYSA-N"
"819","P29762","CRABP-I","AhR","","beta-NF-ATRA","CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CC/C1=N\OCC(=O)NCCOCCOCCOCC1=CC=C(C2=CC(=O)C3=C(C=CC4=CC=CC=C43)O2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00704","802.965","802.382931308","8.31","59","5","9","2","20","145.89","C48H54N2O9","InChI=1S/C48H54N2O9/c1-33(9-8-10-34(2)29-46(53)54)13-19-40-35(3)41(21-22-48(40,4)5)50-58-32-45(52)49-23-24-55-25-26-56-27-28-57-31-36-14-16-38(17-15-36)44-30-42(51)47-39-12-7-6-11-37(39)18-20-43(47)59-44/h6-20,29-30H,21-28,31-32H2,1-5H3,(H,49,52)(H,53,54)/b10-8+,19-13+,33-9+,34-29+,50-41+","MGBFQQQDJPJUNW-DZHZFLTJSA-N"
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"915","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC3=CC=C(/C=N/NC(=O)C4=C(C5=CC=C(O)C=C5)SC5=CC(O)=CC=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1021.228","1020.37614874","6.85","72","7","15","6","22","230.47","C53H60N6O11S2","InChI=1S/C53H60N6O11S2/c1-32(35-8-10-36(11-9-35)47-33(2)54-31-71-47)56-50(64)43-26-40(62)29-59(43)52(66)49(53(3,4)5)57-45(63)30-69-23-22-67-20-21-68-24-25-70-41-17-6-34(7-18-41)28-55-58-51(65)46-42-19-16-39(61)27-44(42)72-48(46)37-12-14-38(60)15-13-37/h6-19,27-28,31-32,40,43,49,60-62H,20-26,29-30H2,1-5H3,(H,56,64)(H,57,63)(H,58,65)/b55-28+/t32-,40+,43-,49+/m0/s1","PEAHSOILUNIYMY-LLXIBUNYSA-N"
"916","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOC3=CC=C(/C=N/NC(=O)C4=C(C5=CC=C(O)C=C5)SC5=CC(O)=CC=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1065.281","1064.40236349","6.7","75","7","16","6","25","239.7","C55H64N6O12S2","InChI=1S/C55H64N6O12S2/c1-34(37-8-10-38(11-9-37)49-35(2)56-33-74-49)58-52(66)45-28-42(64)31-61(45)54(68)51(55(3,4)5)59-47(65)32-72-25-24-70-21-20-69-22-23-71-26-27-73-43-17-6-36(7-18-43)30-57-60-53(67)48-44-19-16-41(63)29-46(44)75-50(48)39-12-14-40(62)15-13-39/h6-19,29-30,33-34,42,45,51,62-64H,20-28,31-32H2,1-5H3,(H,58,66)(H,59,65)(H,60,67)/b57-30+/t34-,42+,45-,51+/m0/s1","LKJUKWAOJJNBTA-VAINNEEBSA-N"
"917","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOC3=CC=C(/C=N/NC(=O)C4=C(C5=CC=C(O)C=C5)SC5=CC(O)=CC=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1109.334","1108.42857824","6.55","78","7","17","6","28","248.93","C57H68N6O13S2","InChI=1S/C57H68N6O13S2/c1-36(39-8-10-40(11-9-39)51-37(2)58-35-77-51)60-54(68)47-30-44(66)33-63(47)56(70)53(57(3,4)5)61-49(67)34-75-27-26-73-23-22-71-20-21-72-24-25-74-28-29-76-45-17-6-38(7-18-45)32-59-62-55(69)50-46-19-16-43(65)31-48(46)78-52(50)41-12-14-42(64)15-13-41/h6-19,31-32,35-36,44,47,53,64-66H,20-30,33-34H2,1-5H3,(H,60,68)(H,61,67)(H,62,69)/b59-32+/t36-,44+,47-,53+/m0/s1","ARZFSLWBGVCWPC-AYXCPXNBSA-N"
"918","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOC3=CC=C(/C=N/NC(=O)C4=C(C5=CC=C(O)C=C5)SC5=CC(O)=CC=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1153.387","1152.45479298","6.4","81","7","18","6","31","258.16","C59H72N6O14S2","InChI=1S/C59H72N6O14S2/c1-38(41-8-10-42(11-9-41)53-39(2)60-37-80-53)62-56(70)49-32-46(68)35-65(49)58(72)55(59(3,4)5)63-51(69)36-78-29-28-76-25-24-74-21-20-73-22-23-75-26-27-77-30-31-79-47-17-6-40(7-18-47)34-61-64-57(71)52-48-19-16-45(67)33-50(48)81-54(52)43-12-14-44(66)15-13-43/h6-19,33-34,37-38,46,49,55,66-68H,20-32,35-36H2,1-5H3,(H,62,70)(H,63,69)(H,64,71)/b61-34+/t38-,46+,49-,55+/m0/s1","IVKDHKVMVNICTO-MMFMNJIKSA-N"
"919","P03372","ER","VHL","","AM-A2","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCOC3=CC=C(CCNC(=O)C4=CC=C(C(=O)C5=C(C6=CC=C(O)C=C6)SC6=CC(O)=CC=C56)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1022.259","1021.37542047","9.21","73","8","12","6","18","207.49","C57H59N5O9S2","InChI=1S/C57H59N5O9S2/c1-33(36-10-14-38(15-11-36)51-34(2)59-32-72-51)60-55(69)46-29-43(65)31-62(46)56(70)53(57(3,4)5)61-48(66)7-6-28-71-44-23-8-35(9-24-44)26-27-58-54(68)40-16-12-37(13-17-40)50(67)49-45-25-22-42(64)30-47(45)73-52(49)39-18-20-41(63)21-19-39/h8-25,30,32-33,43,46,53,63-65H,6-7,26-29,31H2,1-5H3,(H,58,68)(H,60,69)(H,61,66)/t33-,43+,46-,53+/m0/s1","XDOZVPSIUHAKOF-NZBPINMGSA-N"
"920","P03372","ER","VHL","","AM-A3","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(CCNC(=O)C4=CC=C(C(=O)C5=C(C6=CC=C(O)C=C6)SC6=CC(O)=CC=C56)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","1.1","98","Degradation of ERalpha in MCF-7 cells after 6h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13.2/17","Inhibit proliferation of MCF-7/T47D cells","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1036.286","1035.39107053","9.57","74","8","12","6","19","207.49","C58H61N5O9S2","InChI=1S/C58H61N5O9S2/c1-34(37-11-15-39(16-12-37)52-35(2)60-33-73-52)61-56(70)47-30-44(66)32-63(47)57(71)54(58(3,4)5)62-49(67)8-6-7-29-72-45-24-9-36(10-25-45)27-28-59-55(69)41-17-13-38(14-18-41)51(68)50-46-26-23-43(65)31-48(46)74-53(50)40-19-21-42(64)22-20-40/h9-26,31,33-34,44,47,54,64-66H,6-8,27-30,32H2,1-5H3,(H,59,69)(H,61,70)(H,62,67)/t34-,44+,47-,54+/m0/s1","VXEYUCNJDJXFGM-BMAAPKIPSA-N"
"921","P03372","ER","VHL","","AM-A4","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCOC3=CC=C(CCNC(=O)C4=CC=C(C(=O)C5=C(C6=CC=C(O)C=C6)SC6=CC(O)=CC=C56)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00140","1050.313","1049.4067206","9.93","75","8","12","6","20","207.49","C59H63N5O9S2","InChI=1S/C59H63N5O9S2/c1-35(38-12-16-40(17-13-38)53-36(2)61-34-74-53)62-57(71)48-31-45(67)33-64(48)58(72)55(59(3,4)5)63-50(68)9-7-6-8-30-73-46-25-10-37(11-26-46)28-29-60-56(70)42-18-14-39(15-19-42)52(69)51-47-27-24-44(66)32-49(47)75-54(51)41-20-22-43(65)23-21-41/h10-27,32,34-35,45,48,55,65-67H,6-9,28-31,33H2,1-5H3,(H,60,70)(H,62,71)(H,63,68)/t35-,45+,48-,55+/m0/s1","SYECUFDPZALRKP-OONWOZLCSA-N"
"922","Q96BR1","SGK3","VHL","","DAT1","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","","440","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1101.294","1100.42597312","4.52","77","8","17","5","24","261.65","C53H65FN10O11S2","InChI=1S/C53H65FN10O11S2/c1-33-6-15-42(54)44(24-33)77(69,70)62-38-13-11-37(12-14-38)48-59-49-41(27-57-61-49)51(60-48)75-30-40-29-63(17-19-74-40)16-18-71-20-21-72-22-23-73-31-45(66)58-47(53(3,4)5)52(68)64-28-39(65)25-43(64)50(67)55-26-35-7-9-36(10-8-35)46-34(2)56-32-76-46/h6-15,24,27,32,39-40,43,47,62,65H,16-23,25-26,28-31H2,1-5H3,(H,55,67)(H,58,66)(H,57,59,60,61)/t39-,40-,43+,47-/m1/s1","PBLWKUZHYRMOOP-QNYGULOBSA-N"
"923","Q96BR1","SGK3","VHL","","DAT2","COC1=CC=C(Cl)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C(C)=N[NH]C4=N3)C=C2)=C1","","","","","","190","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1147.775","1146.40698726","5.06","79","8","18","5","25","270.88","C54H67ClN10O12S2","InChI=1S/C54H67ClN10O12S2/c1-33-46-50(62-61-33)59-49(37-11-13-38(14-12-37)63-79(70,71)44-26-40(72-6)15-16-42(44)55)60-52(46)77-30-41-29-64(18-20-76-41)17-19-73-21-22-74-23-24-75-31-45(67)58-48(54(3,4)5)53(69)65-28-39(66)25-43(65)51(68)56-27-35-7-9-36(10-8-35)47-34(2)57-32-78-47/h7-16,26,32,39,41,43,48,63,66H,17-25,27-31H2,1-6H3,(H,56,68)(H,58,67)(H,59,60,61,62)/t39-,41-,43+,48-/m1/s1","HQOHKSOIBFLAPW-KCMSOMBGSA-N"
"924","Q96BR1","SGK3","CRBN","","DAT3","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCC(=O)NCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","","640","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","987.037","986.339266292","2.19","70","8","17","5","23","274.7","C46H51FN10O12S","InChI=1S/C46H51FN10O12S/c1-28-5-10-34(47)37(23-28)70(63,64)55-30-8-6-29(7-9-30)41-52-42-33(24-50-54-42)44(53-41)69-26-31-25-56(16-18-68-31)15-17-65-19-20-66-21-22-67-27-39(59)49-14-13-48-35-4-2-3-32-40(35)46(62)57(45(32)61)36-11-12-38(58)51-43(36)60/h2-10,23-24,31,36,48,55H,11-22,25-27H2,1H3,(H,49,59)(H,51,58,60)(H,50,52,53,54)/t31-,36?/m1/s1","OUCDUDOBVVHZKG-RACIXVTASA-N"
"925","Q96BR1","SGK3","CRBN","","DAT4","COC1=CC=C(Cl)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCC(=O)NCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CCO4)=C4C(C)=N[NH]C4=N3)C=C2)=C1","","","","","","540","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1033.518","1032.32028044","2.72","72","8","18","5","24","283.93","C47H53ClN10O13S","InChI=1S/C47H53ClN10O13S/c1-28-40-43(55-54-28)52-42(29-6-8-30(9-7-29)56-72(64,65)37-24-31(66-2)10-11-34(37)48)53-45(40)71-26-32-25-57(17-19-70-32)16-18-67-20-21-68-22-23-69-27-39(60)50-15-14-49-35-5-3-4-33-41(35)47(63)58(46(33)62)36-12-13-38(59)51-44(36)61/h3-11,24,32,36,49,56H,12-23,25-27H2,1-2H3,(H,50,60)(H,51,59,61)(H,52,53,54,55)/t32-,36?/m1/s1","LPBWDJDWCDHURM-NQUIPPIDSA-N"
"926","Q96BR1","SGK3","VHL","","DAT5","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","",">10000","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1057.241","1056.39975837","4.67","74","8","16","5","21","252.42","C51H61FN10O10S2","InChI=1S/C51H61FN10O10S2/c1-31-6-15-40(52)42(22-31)74(67,68)60-36-13-11-35(12-14-36)46-57-47-39(25-55-59-47)49(58-46)72-28-38-27-61(17-19-71-38)16-18-69-20-21-70-29-43(64)56-45(51(3,4)5)50(66)62-26-37(63)23-41(62)48(65)53-24-33-7-9-34(10-8-33)44-32(2)54-30-73-44/h6-15,22,25,30,37-38,41,45,60,63H,16-21,23-24,26-29H2,1-5H3,(H,53,65)(H,56,64)(H,55,57,58,59)/t37-,38-,41+,45-/m1/s1","JXCYSULNBQLMPI-KLJZNDRGSA-N"
"927","Q96BR1","SGK3","VHL","","DAT6","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","",">10000","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1145.347","1144.45218787","4.38","80","8","18","5","27","270.88","C55H69FN10O12S2","InChI=1S/C55H69FN10O12S2/c1-35-6-15-44(56)46(26-35)80(71,72)64-40-13-11-39(12-14-40)50-61-51-43(29-59-63-51)53(62-50)78-32-42-31-65(17-19-77-42)16-18-73-20-21-74-22-23-75-24-25-76-33-47(68)60-49(55(3,4)5)54(70)66-30-41(67)27-45(66)52(69)57-28-37-7-9-38(10-8-37)48-36(2)58-34-79-48/h6-15,26,29,34,41-42,45,49,64,67H,16-25,27-28,30-33H2,1-5H3,(H,57,69)(H,60,68)(H,59,61,62,63)/t41-,42-,45+,49-/m1/s1","YGCOGEJGSHXAEY-GPEIHWJGSA-N"
"928","Q96BR1","SGK3","VHL","","DAT7","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","",">10000","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1189.4","1188.47840262","4.23","83","8","19","5","30","280.11","C57H73FN10O13S2","InChI=1S/C57H73FN10O13S2/c1-37-6-15-46(58)48(28-37)83(73,74)66-42-13-11-41(12-14-42)52-63-53-45(31-61-65-53)55(64-52)81-34-44-33-67(17-19-80-44)16-18-75-20-21-76-22-23-77-24-25-78-26-27-79-35-49(70)62-51(57(3,4)5)56(72)68-32-43(69)29-47(68)54(71)59-30-39-7-9-40(10-8-39)50-38(2)60-36-82-50/h6-15,28,31,36,43-44,47,51,66,69H,16-27,29-30,32-35H2,1-5H3,(H,59,71)(H,62,70)(H,61,63,64,65)/t43-,44-,47+,51-/m1/s1","NFWARMHJBLHFEP-RIAKQDHQSA-N"
"929","Q96BR1","SGK3","VHL","","SGK3-PROTAC1","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCCCCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","","300","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1157.402","1156.48857338","5.95","81","8","17","5","28","261.65","C57H73FN10O11S2","InChI=1S/C57H73FN10O11S2/c1-37-10-19-46(58)48(28-37)81(73,74)66-42-17-15-41(16-18-42)52-63-53-45(31-61-65-53)55(64-52)79-34-44-33-67(21-23-78-44)20-8-6-7-9-22-75-24-25-76-26-27-77-35-49(70)62-51(57(3,4)5)56(72)68-32-43(69)29-47(68)54(71)59-30-39-11-13-40(14-12-39)50-38(2)60-36-80-50/h10-19,28,31,36,43-44,47,51,66,69H,6-9,20-27,29-30,32-35H2,1-5H3,(H,59,71)(H,62,70)(H,61,63,64,65)/t43-,44-,47+,51-/m1/s1","RTFQFPZKDYMMMJ-RIAKQDHQSA-N"
"930","Q96BR1","SGK3","VHL","","DAT9","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCCCCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","","1790","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1201.455","1200.51478812","5.8","84","8","18","5","31","270.88","C59H77FN10O12S2","InChI=1S/C59H77FN10O12S2/c1-39-10-19-48(60)50(30-39)84(75,76)68-44-17-15-43(16-18-44)54-65-55-47(33-63-67-55)57(66-54)82-36-46-35-69(21-23-81-46)20-8-6-7-9-22-77-24-25-78-26-27-79-28-29-80-37-51(72)64-53(59(3,4)5)58(74)70-34-45(71)31-49(70)56(73)61-32-41-11-13-42(14-12-41)52-40(2)62-38-83-52/h10-19,30,33,38,45-46,49,53,68,71H,6-9,20-29,31-32,34-37H2,1-5H3,(H,61,73)(H,64,72)(H,63,65,66,67)/t45-,46-,49+,53-/m1/s1","VRPWBMZBYLPNEA-XFFPAYIQSA-N"
"931","Q96BR1","SGK3","VHL","","DAT10","CC1=CC=C(F)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCCCCCOCCCCCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C=N[NH]C4=N3)C=C2)=C1","","","","","",">10000","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1169.457","1168.52495888","7.53","82","8","16","5","29","252.42","C59H77FN10O10S2","InChI=1S/C59H77FN10O10S2/c1-39-14-23-48(60)50(30-39)82(75,76)68-44-21-19-43(20-22-44)54-65-55-47(33-63-67-55)57(66-54)80-36-46-35-69(25-29-79-46)24-10-6-7-11-26-77-27-12-8-9-13-28-78-37-51(72)64-53(59(3,4)5)58(74)70-34-45(71)31-49(70)56(73)61-32-41-15-17-42(18-16-41)52-40(2)62-38-81-52/h14-23,30,33,38,45-46,49,53,68,71H,6-13,24-29,31-32,34-37H2,1-5H3,(H,61,73)(H,64,72)(H,63,65,66,67)/t45-,46-,49+,53-/m1/s1","OTAFGOFPDRSGCZ-XFFPAYIQSA-N"
"932","Q96BR1","SGK3","VHL","","DAT11","COC1=CC=C(Cl)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCCCCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C(C)=N[NH]C4=N3)C=C2)=C1","","","","","","730","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1247.936","1246.49580227","6.34","86","8","19","5","32","280.11","C60H79ClN10O13S2","InChI=1S/C60H79ClN10O13S2/c1-39-52-56(68-67-39)65-55(43-15-17-44(18-16-43)69-86(76,77)50-32-46(78-6)19-20-48(50)61)66-58(52)84-36-47-35-70(22-24-83-47)21-9-7-8-10-23-79-25-26-80-27-28-81-29-30-82-37-51(73)64-54(60(3,4)5)59(75)71-34-45(72)31-49(71)57(74)62-33-41-11-13-42(14-12-41)53-40(2)63-38-85-53/h11-20,32,38,45,47,49,54,69,72H,7-10,21-31,33-37H2,1-6H3,(H,62,74)(H,64,73)(H,65,66,67,68)/t45-,47-,49+,54-/m1/s1","LRTZEVJYEWWQSI-NGSZLDIUSA-N"
"933","Q96BR1","SGK3","VHL","","DAT12","COC1=CC=C(Cl)C(S(=O)(=O)NC2=CC=C(C3=NC(OC[C@H]4CN(CCCCCCOCCCCCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CCO4)=C4C(C)=N[NH]C4=N3)C=C2)=C1","","","","","",">10000","Inhibition of SGK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00505","1215.938","1214.50597303","8.06","84","8","17","5","30","261.65","C60H79ClN10O11S2","InChI=1S/C60H79ClN10O11S2/c1-39-52-56(68-67-39)65-55(43-19-21-44(22-20-43)69-84(76,77)50-32-46(78-6)23-24-48(50)61)66-58(52)82-36-47-35-70(26-30-81-47)25-11-7-8-12-27-79-28-13-9-10-14-29-80-37-51(73)64-54(60(3,4)5)59(75)71-34-45(72)31-49(71)57(74)62-33-41-15-17-42(18-16-41)53-40(2)63-38-83-53/h15-24,32,38,45,47,49,54,69,72H,7-14,25-31,33-37H2,1-6H3,(H,62,74)(H,64,73)(H,65,66,67,68)/t45-,47-,49+,54-/m1/s1","FCKRMJWQSYSUOR-NGSZLDIUSA-N"
"934","O75530","EED","VHL","","","CC1=NC(CCC(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","0.5","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","57/620","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","960.15","959.427627796","5.68","69","8","14","5","18","217.96","C50H58FN11O6S","InChI=1S/C50H58FN11O6S/c1-29-35(38-25-55-49(62-27-57-60-46(38)62)54-24-37-36-19-21-68-41(36)17-16-39(37)51)15-13-33(58-29)14-18-42(64)52-20-7-6-8-43(65)59-45(50(3,4)5)48(67)61-26-34(63)22-40(61)47(66)53-23-31-9-11-32(12-10-31)44-30(2)56-28-69-44/h9-13,15-17,25,27-28,34,40,45,63H,6-8,14,18-24,26H2,1-5H3,(H,52,64)(H,53,66)(H,54,55)(H,59,65)/t34-,40+,45-/m1/s1","CQSOTYMFUWTIIR-HUSBZTEESA-N"
"934","Q15910","EZH2","VHL","","","CC1=NC(CCC(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","57/620","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","960.15","959.427627796","5.68","69","8","14","5","18","217.96","C50H58FN11O6S","InChI=1S/C50H58FN11O6S/c1-29-35(38-25-55-49(62-27-57-60-46(38)62)54-24-37-36-19-21-68-41(36)17-16-39(37)51)15-13-33(58-29)14-18-42(64)52-20-7-6-8-43(65)59-45(50(3,4)5)48(67)61-26-34(63)22-40(61)47(66)53-23-31-9-11-32(12-10-31)44-30(2)56-28-69-44/h9-13,15-17,25,27-28,34,40,45,63H,6-8,14,18-24,26H2,1-5H3,(H,52,64)(H,53,66)(H,54,55)(H,59,65)/t34-,40+,45-/m1/s1","CQSOTYMFUWTIIR-HUSBZTEESA-N"
"934","Q15022","SUZ12","VHL","","","CC1=NC(CCC(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","57/620","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","960.15","959.427627796","5.68","69","8","14","5","18","217.96","C50H58FN11O6S","InChI=1S/C50H58FN11O6S/c1-29-35(38-25-55-49(62-27-57-60-46(38)62)54-24-37-36-19-21-68-41(36)17-16-39(37)51)15-13-33(58-29)14-18-42(64)52-20-7-6-8-43(65)59-45(50(3,4)5)48(67)61-26-34(63)22-40(61)47(66)53-23-31-9-11-32(12-10-31)44-30(2)56-28-69-44/h9-13,15-17,25,27-28,34,40,45,63H,6-8,14,18-24,26H2,1-5H3,(H,52,64)(H,53,66)(H,54,55)(H,59,65)/t34-,40+,45-/m1/s1","CQSOTYMFUWTIIR-HUSBZTEESA-N"
"935","O75530","EED","VHL","","","CC1=NC(CCC(=O)NCCOC2=CC=C(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","1","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45/260","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","1054.219","1053.4331071","6.7","76","9","16","5","20","236.42","C55H60FN11O8S","InChI=1S/C55H60FN11O8S/c1-32-40(43-27-60-54(67-30-62-65-51(43)67)59-26-42-41-20-22-74-46(41)18-17-44(42)56)16-10-36(63-32)11-19-47(69)57-21-23-73-38-12-14-39(15-13-38)75-29-48(70)64-50(55(3,4)5)53(72)66-28-37(68)24-45(66)52(71)58-25-34-6-8-35(9-7-34)49-33(2)61-31-76-49/h6-10,12-18,27,30-31,37,45,50,68H,11,19-26,28-29H2,1-5H3,(H,57,69)(H,58,71)(H,59,60)(H,64,70)/t37-,45+,50-/m1/s1","FSFJUWLIBSALJI-FENRPDQVSA-N"
"935","Q15910","EZH2","VHL","","","CC1=NC(CCC(=O)NCCOC2=CC=C(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45/260","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","1054.219","1053.4331071","6.7","76","9","16","5","20","236.42","C55H60FN11O8S","InChI=1S/C55H60FN11O8S/c1-32-40(43-27-60-54(67-30-62-65-51(43)67)59-26-42-41-20-22-74-46(41)18-17-44(42)56)16-10-36(63-32)11-19-47(69)57-21-23-73-38-12-14-39(15-13-38)75-29-48(70)64-50(55(3,4)5)53(72)66-28-37(68)24-45(66)52(71)58-25-34-6-8-35(9-7-34)49-33(2)61-31-76-49/h6-10,12-18,27,30-31,37,45,50,68H,11,19-26,28-29H2,1-5H3,(H,57,69)(H,58,71)(H,59,60)(H,64,70)/t37-,45+,50-/m1/s1","FSFJUWLIBSALJI-FENRPDQVSA-N"
"935","Q15022","SUZ12","VHL","","","CC1=NC(CCC(=O)NCCOC2=CC=C(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=CC=C1C1=CN=C(NCC2=C(F)C=CC3=C2CCO3)N2C=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45/260","Inhibit proliferation of Karpas422/G401 cells","","","","","","","","","","","10.1016/j.chembiol.2019.11.004","1054.219","1053.4331071","6.7","76","9","16","5","20","236.42","C55H60FN11O8S","InChI=1S/C55H60FN11O8S/c1-32-40(43-27-60-54(67-30-62-65-51(43)67)59-26-42-41-20-22-74-46(41)18-17-44(42)56)16-10-36(63-32)11-19-47(69)57-21-23-73-38-12-14-39(15-13-38)75-29-48(70)64-50(55(3,4)5)53(72)66-28-37(68)24-45(66)52(71)58-25-34-6-8-35(9-7-34)49-33(2)61-31-76-49/h6-10,12-18,27,30-31,37,45,50,68H,11,19-26,28-29H2,1-5H3,(H,57,69)(H,58,71)(H,59,60)(H,64,70)/t37-,45+,50-/m1/s1","FSFJUWLIBSALJI-FENRPDQVSA-N"
"936","O75530","EED","VHL","","UNC6851","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","275","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","818.961","818.332250192","4.36","59","7","13","5","14","208.98","C42H46N10O6S","InChI=1S/C42H46N10O6S/c1-25-35(59-24-47-25)28-9-7-26(8-10-28)19-44-39(56)33-18-30(53)22-51(33)40(57)36(42(2,3)4)49-34(54)15-16-43-38(55)29-13-11-27(12-14-29)32-21-46-41(52-23-48-50-37(32)52)45-20-31-6-5-17-58-31/h5-14,17,21,23-24,30,33,36,53H,15-16,18-20,22H2,1-4H3,(H,43,55)(H,44,56)(H,45,46)(H,49,54)/t30-,33+,36-/m1/s1","SKNNVIMYXZKMLZ-WUXNRVTNSA-N"
"936","Q15910","EZH2","VHL","","UNC6851","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","818.961","818.332250192","4.36","59","7","13","5","14","208.98","C42H46N10O6S","InChI=1S/C42H46N10O6S/c1-25-35(59-24-47-25)28-9-7-26(8-10-28)19-44-39(56)33-18-30(53)22-51(33)40(57)36(42(2,3)4)49-34(54)15-16-43-38(55)29-13-11-27(12-14-29)32-21-46-41(52-23-48-50-37(32)52)45-20-31-6-5-17-58-31/h5-14,17,21,23-24,30,33,36,53H,15-16,18-20,22H2,1-4H3,(H,43,55)(H,44,56)(H,45,46)(H,49,54)/t30-,33+,36-/m1/s1","SKNNVIMYXZKMLZ-WUXNRVTNSA-N"
"936","Q15022","SUZ12","VHL","","UNC6851","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","818.961","818.332250192","4.36","59","7","13","5","14","208.98","C42H46N10O6S","InChI=1S/C42H46N10O6S/c1-25-35(59-24-47-25)28-9-7-26(8-10-28)19-44-39(56)33-18-30(53)22-51(33)40(57)36(42(2,3)4)49-34(54)15-16-43-38(55)29-13-11-27(12-14-29)32-21-46-41(52-23-48-50-37(32)52)45-20-31-6-5-17-58-31/h5-14,17,21,23-24,30,33,36,53H,15-16,18-20,22H2,1-4H3,(H,43,55)(H,44,56)(H,45,46)(H,49,54)/t30-,33+,36-/m1/s1","SKNNVIMYXZKMLZ-WUXNRVTNSA-N"
"937","O75530","EED","VHL","","UNC6852","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","790/610","92/94","Degradation of EED in HeLa/DB cells after 24 h treatment","","","247","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3400/410","Inhibit proliferation of DB/Pfeiffer cells","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","832.988","832.347900256","4.72","60","7","13","5","15","208.98","C43H48N10O6S","InChI=1S/C43H48N10O6S/c1-26-36(60-25-48-26)29-11-9-27(10-12-29)20-45-40(57)34-19-31(54)23-52(34)41(58)37(43(2,3)4)50-35(55)8-5-17-44-39(56)30-15-13-28(14-16-30)33-22-47-42(53-24-49-51-38(33)53)46-21-32-7-6-18-59-32/h6-7,9-16,18,22,24-25,31,34,37,54H,5,8,17,19-21,23H2,1-4H3,(H,44,56)(H,45,57)(H,46,47)(H,50,55)/t31-,34+,37-/m1/s1","PPNNFXIBKLCMTI-WXEAQWFJSA-N"
"937","Q15910","EZH2","VHL","","UNC6852","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","300/670","75/96","Degradation of EZH2 in HeLa/DB cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3400/410","Inhibit proliferation of DB/Pfeiffer cells","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","832.988","832.347900256","4.72","60","7","13","5","15","208.98","C43H48N10O6S","InChI=1S/C43H48N10O6S/c1-26-36(60-25-48-26)29-11-9-27(10-12-29)20-45-40(57)34-19-31(54)23-52(34)41(58)37(43(2,3)4)50-35(55)8-5-17-44-39(56)30-15-13-28(14-16-30)33-22-47-42(53-24-49-51-38(33)53)46-21-32-7-6-18-59-32/h6-7,9-16,18,22,24-25,31,34,37,54H,5,8,17,19-21,23H2,1-4H3,(H,44,56)(H,45,57)(H,46,47)(H,50,55)/t31-,34+,37-/m1/s1","PPNNFXIBKLCMTI-WXEAQWFJSA-N"
"937","Q15022","SUZ12","VHL","","UNC6852","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","(n/a)/590","22/82","Degradation of SUZ12 in HeLa/DB cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3400/410","Inhibit proliferation of DB/Pfeiffer cells","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","832.988","832.347900256","4.72","60","7","13","5","15","208.98","C43H48N10O6S","InChI=1S/C43H48N10O6S/c1-26-36(60-25-48-26)29-11-9-27(10-12-29)20-45-40(57)34-19-31(54)23-52(34)41(58)37(43(2,3)4)50-35(55)8-5-17-44-39(56)30-15-13-28(14-16-30)33-22-47-42(53-24-49-51-38(33)53)46-21-32-7-6-18-59-32/h6-7,9-16,18,22,24-25,31,34,37,54H,5,8,17,19-21,23H2,1-4H3,(H,44,56)(H,45,57)(H,46,47)(H,50,55)/t31-,34+,37-/m1/s1","PPNNFXIBKLCMTI-WXEAQWFJSA-N"
"938","O75530","EED","VHL","","UNC6853","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","368","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","847.015","846.36355032","5.07","61","7","13","5","16","208.98","C44H50N10O6S","InChI=1S/C44H50N10O6S/c1-27-37(61-26-49-27)30-12-10-28(11-13-30)21-46-41(58)35-20-32(55)24-53(35)42(59)38(44(2,3)4)51-36(56)9-5-6-18-45-40(57)31-16-14-29(15-17-31)34-23-48-43(54-25-50-52-39(34)54)47-22-33-8-7-19-60-33/h7-8,10-17,19,23,25-26,32,35,38,55H,5-6,9,18,20-22,24H2,1-4H3,(H,45,57)(H,46,58)(H,47,48)(H,51,56)/t32-,35+,38-/m1/s1","PCXRLENLMVJWLZ-UZQUTMQESA-N"
"938","Q15910","EZH2","VHL","","UNC6853","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","847.015","846.36355032","5.07","61","7","13","5","16","208.98","C44H50N10O6S","InChI=1S/C44H50N10O6S/c1-27-37(61-26-49-27)30-12-10-28(11-13-30)21-46-41(58)35-20-32(55)24-53(35)42(59)38(44(2,3)4)51-36(56)9-5-6-18-45-40(57)31-16-14-29(15-17-31)34-23-48-43(54-25-50-52-39(34)54)47-22-33-8-7-19-60-33/h7-8,10-17,19,23,25-26,32,35,38,55H,5-6,9,18,20-22,24H2,1-4H3,(H,45,57)(H,46,58)(H,47,48)(H,51,56)/t32-,35+,38-/m1/s1","PCXRLENLMVJWLZ-UZQUTMQESA-N"
"938","Q15022","SUZ12","VHL","","UNC6853","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","847.015","846.36355032","5.07","61","7","13","5","16","208.98","C44H50N10O6S","InChI=1S/C44H50N10O6S/c1-27-37(61-26-49-27)30-12-10-28(11-13-30)21-46-41(58)35-20-32(55)24-53(35)42(59)38(44(2,3)4)51-36(56)9-5-6-18-45-40(57)31-16-14-29(15-17-31)34-23-48-43(54-25-50-52-39(34)54)47-22-33-8-7-19-60-33/h7-8,10-17,19,23,25-26,32,35,38,55H,5-6,9,18,20-22,24H2,1-4H3,(H,45,57)(H,46,58)(H,47,48)(H,51,56)/t32-,35+,38-/m1/s1","PCXRLENLMVJWLZ-UZQUTMQESA-N"
"939","O75530","EED","VHL","","UNC6845","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","82","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","907.067","906.384679688","4.06","65","7","15","5","20","227.44","C46H54N10O8S","InChI=1S/C46H54N10O8S/c1-29-39(65-28-51-29)32-9-7-30(8-10-32)23-48-43(60)37-22-34(57)26-55(37)44(61)40(46(2,3)4)53-38(58)15-18-62-20-21-63-19-16-47-42(59)33-13-11-31(12-14-33)36-25-50-45(56-27-52-54-41(36)56)49-24-35-6-5-17-64-35/h5-14,17,25,27-28,34,37,40,57H,15-16,18-24,26H2,1-4H3,(H,47,59)(H,48,60)(H,49,50)(H,53,58)/t34-,37+,40-/m1/s1","CNBCIJQNEDIWMK-WPPCIPCFSA-N"
"939","Q15910","EZH2","VHL","","UNC6845","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","907.067","906.384679688","4.06","65","7","15","5","20","227.44","C46H54N10O8S","InChI=1S/C46H54N10O8S/c1-29-39(65-28-51-29)32-9-7-30(8-10-32)23-48-43(60)37-22-34(57)26-55(37)44(61)40(46(2,3)4)53-38(58)15-18-62-20-21-63-19-16-47-42(59)33-13-11-31(12-14-33)36-25-50-45(56-27-52-54-41(36)56)49-24-35-6-5-17-64-35/h5-14,17,25,27-28,34,37,40,57H,15-16,18-24,26H2,1-4H3,(H,47,59)(H,48,60)(H,49,50)(H,53,58)/t34-,37+,40-/m1/s1","CNBCIJQNEDIWMK-WPPCIPCFSA-N"
"939","Q15022","SUZ12","VHL","","UNC6845","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","907.067","906.384679688","4.06","65","7","15","5","20","227.44","C46H54N10O8S","InChI=1S/C46H54N10O8S/c1-29-39(65-28-51-29)32-9-7-30(8-10-32)23-48-43(60)37-22-34(57)26-55(37)44(61)40(46(2,3)4)53-38(58)15-18-62-20-21-63-19-16-47-42(59)33-13-11-31(12-14-33)36-25-50-45(56-27-52-54-41(36)56)49-24-35-6-5-17-64-35/h5-14,17,25,27-28,34,37,40,57H,15-16,18-24,26H2,1-4H3,(H,47,59)(H,48,60)(H,49,50)(H,53,58)/t34-,37+,40-/m1/s1","CNBCIJQNEDIWMK-WPPCIPCFSA-N"
"940","O75530","EED","VHL","","UNC6846","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","613","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","937.093","936.395244372","4.01","67","7","16","5","22","236.67","C47H56N10O9S","InChI=1S/C47H56N10O9S/c1-30-40(67-29-52-30)33-9-7-31(8-10-33)23-49-44(61)38-22-35(58)26-56(38)45(62)41(47(2,3)4)54-39(59)27-65-21-20-64-19-18-63-17-15-48-43(60)34-13-11-32(12-14-34)37-25-51-46(57-28-53-55-42(37)57)50-24-36-6-5-16-66-36/h5-14,16,25,28-29,35,38,41,58H,15,17-24,26-27H2,1-4H3,(H,48,60)(H,49,61)(H,50,51)(H,54,59)/t35-,38+,41-/m1/s1","MKRMIGNBGFQRAG-LFHXYJAASA-N"
"940","Q15910","EZH2","VHL","","UNC6846","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","937.093","936.395244372","4.01","67","7","16","5","22","236.67","C47H56N10O9S","InChI=1S/C47H56N10O9S/c1-30-40(67-29-52-30)33-9-7-31(8-10-33)23-49-44(61)38-22-35(58)26-56(38)45(62)41(47(2,3)4)54-39(59)27-65-21-20-64-19-18-63-17-15-48-43(60)34-13-11-32(12-14-34)37-25-51-46(57-28-53-55-42(37)57)50-24-36-6-5-16-66-36/h5-14,16,25,28-29,35,38,41,58H,15,17-24,26-27H2,1-4H3,(H,48,60)(H,49,61)(H,50,51)(H,54,59)/t35-,38+,41-/m1/s1","MKRMIGNBGFQRAG-LFHXYJAASA-N"
"940","Q15022","SUZ12","VHL","","UNC6846","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","937.093","936.395244372","4.01","67","7","16","5","22","236.67","C47H56N10O9S","InChI=1S/C47H56N10O9S/c1-30-40(67-29-52-30)33-9-7-31(8-10-33)23-49-44(61)38-22-35(58)26-56(38)45(62)41(47(2,3)4)54-39(59)27-65-21-20-64-19-18-63-17-15-48-43(60)34-13-11-32(12-14-34)37-25-51-46(57-28-53-55-42(37)57)50-24-36-6-5-16-66-36/h5-14,16,25,28-29,35,38,41,58H,15,17-24,26-27H2,1-4H3,(H,48,60)(H,49,61)(H,50,51)(H,54,59)/t35-,38+,41-/m1/s1","MKRMIGNBGFQRAG-LFHXYJAASA-N"
"941","O75530","EED","VHL","","UNC6847","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","241","IC50 of EED was tested by the TR-FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","995.173","994.437109184","3.77","71","7","17","5","26","245.9","C50H62N10O10S","InChI=1S/C50H62N10O10S/c1-33-43(71-32-55-33)36-9-7-34(8-10-36)27-52-47(64)41-26-38(61)30-59(41)48(65)44(50(2,3)4)57-42(62)15-18-66-20-22-68-24-25-69-23-21-67-19-16-51-46(63)37-13-11-35(12-14-37)40-29-54-49(60-31-56-58-45(40)60)53-28-39-6-5-17-70-39/h5-14,17,29,31-32,38,41,44,61H,15-16,18-28,30H2,1-4H3,(H,51,63)(H,52,64)(H,53,54)(H,57,62)/t38-,41+,44-/m1/s1","RKBUODRBMAVLOC-UMWCMSNQSA-N"
"941","Q15910","EZH2","VHL","","UNC6847","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","995.173","994.437109184","3.77","71","7","17","5","26","245.9","C50H62N10O10S","InChI=1S/C50H62N10O10S/c1-33-43(71-32-55-33)36-9-7-34(8-10-36)27-52-47(64)41-26-38(61)30-59(41)48(65)44(50(2,3)4)57-42(62)15-18-66-20-22-68-24-25-69-23-21-67-19-16-51-46(63)37-13-11-35(12-14-37)40-29-54-49(60-31-56-58-45(40)60)53-28-39-6-5-17-70-39/h5-14,17,29,31-32,38,41,44,61H,15-16,18-28,30H2,1-4H3,(H,51,63)(H,52,64)(H,53,54)(H,57,62)/t38-,41+,44-/m1/s1","RKBUODRBMAVLOC-UMWCMSNQSA-N"
"941","Q15022","SUZ12","VHL","","UNC6847","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)C3=CC=C(C4=CN=C(NCC5=CC=CO5)N5C=NN=C45)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.11.006","995.173","994.437109184","3.77","71","7","17","5","26","245.9","C50H62N10O10S","InChI=1S/C50H62N10O10S/c1-33-43(71-32-55-33)36-9-7-34(8-10-36)27-52-47(64)41-26-38(61)30-59(41)48(65)44(50(2,3)4)57-42(62)15-18-66-20-22-68-24-25-69-23-21-67-19-16-51-46(63)37-13-11-35(12-14-37)40-29-54-49(60-31-56-58-45(40)60)53-28-39-6-5-17-70-39/h5-14,17,29,31-32,38,41,44,61H,15-16,18-28,30H2,1-4H3,(H,51,63)(H,52,64)(H,53,54)(H,57,62)/t38-,41+,44-/m1/s1","RKBUODRBMAVLOC-UMWCMSNQSA-N"
"942","P31749","AKT1","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","2","IC50 of AKT1 was tested by Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16/178/130","Inhibit proliferation of ZR-75-1/T47D/LNCaP cells","","","","","","","10.1016/j.chembiol.2019.11.014","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"942","P31751","AKT2","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","6.8","IC50 of AKT2 was tested by Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16/178/130","Inhibit proliferation of ZR-75-1/T47D/LNCaP cells","","","","","","","10.1016/j.chembiol.2019.11.014","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"942","Q9Y243","AKT3","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","3.5","IC50 of AKT3 was tested by Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16/178/130","Inhibit proliferation of ZR-75-1/T47D/LNCaP cells","","","","","","","10.1016/j.chembiol.2019.11.014","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"942","P11802","CDK4","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"942","Q16659","MAPK6","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"942","Q9UEE5","STK17A","CRBN","","INY-03-041","C[C@@H]1C[C@@H](O)C2=NC=NC(N3CCN(C(=O)[C@H](CNCCCCCCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C4=CC=C(Cl)C=C4)CC3)=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","798.429","797.403145572","5.84","57","7","9","3","17","148.07","C44H56ClN7O5","InChI=1S/C44H56ClN7O5/c1-29-25-37(53)40-39(29)41(48-28-47-40)50-21-23-51(24-22-50)43(56)34(31-14-16-32(45)17-15-31)26-46-20-9-7-5-3-2-4-6-8-11-30-12-10-13-33-35(30)27-52(44(33)57)36-18-19-38(54)49-42(36)55/h10,12-17,28-29,34,36-37,46,53H,2-9,11,18-27H2,1H3,(H,49,54,55)/t29-,34-,36?,37-/m1/s1","GQGZWBDNMCIYSF-OZDCPDTESA-N"
"943","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)NCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","764","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","936.398","935.316929984","5.36","67","8","14","5","18","224.73","C47H47ClFN9O9","InChI=1S/C47H47ClFN9O9/c1-2-38(62)56-16-18-57(19-17-56)43-32-26-33(48)39(31-25-28(59)24-27-6-3-4-7-29(27)31)41(49)42(32)54-47(55-43)52-13-12-36(60)51-15-21-67-23-22-66-20-14-50-34-9-5-8-30-40(34)46(65)58(45(30)64)35-10-11-37(61)53-44(35)63/h2-9,24-26,35,50,59H,1,10-23H2,(H,51,60)(H,52,54,55)(H,53,61,63)","ODGGYJAKYDILGA-UHFFFAOYSA-N"
"944","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)NCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","20330","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","1024.504","1023.36935948","5.07","73","8","16","5","24","243.19","C51H55ClFN9O11","InChI=1S/C51H55ClFN9O11/c1-2-42(66)60-16-18-61(19-17-60)47-36-30-37(52)43(35-29-32(63)28-31-6-3-4-7-33(31)35)45(53)46(36)58-51(59-47)56-13-12-40(64)55-15-21-71-23-25-73-27-26-72-24-22-70-20-14-54-38-9-5-8-34-44(38)50(69)62(49(34)68)39-10-11-41(65)57-48(39)67/h2-9,28-30,39,54,63H,1,10-27H2,(H,55,64)(H,56,58,59)(H,57,65,67)","DAKJVBKAHBEOKW-UHFFFAOYSA-N"
"945","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCCC3=CN(COCCOCCOCCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","5724","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","1018.504","1017.37002818","4.19","73","9","16","4","21","235.57","C51H53ClFN11O9","InChI=1S/C51H53ClFN11O9/c1-2-44(68)61-16-18-62(19-17-61)48-37-27-39(52)45(36-26-33(65)25-31-7-3-4-9-34(31)36)46(53)47(37)57-51(58-48)54-15-6-8-32-28-63(60-59-32)30-73-24-23-72-22-21-71-20-14-43(67)55-40-11-5-10-35-38(40)29-64(50(35)70)41-12-13-42(66)56-49(41)69/h2-5,7,9-11,25-28,41,65H,1,6,8,12-24,29-30H2,(H,55,67)(H,54,57,58)(H,56,66,69)","GPXFRGDBNKEVRH-UHFFFAOYSA-N"
"946","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCOCCC3=CN(COCCOCCOCCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","1136.636","1135.43302236","3.39","81","9","19","4","29","263.26","C56H63ClFN11O12","InChI=1S/C56H63ClFN11O12/c1-2-49(73)66-15-17-67(18-16-66)53-42-32-44(57)50(41-31-38(70)30-36-6-3-4-7-39(36)41)51(58)52(42)62-56(63-53)59-14-21-78-24-27-79-25-22-76-19-12-37-33-68(65-64-37)35-81-29-28-80-26-23-77-20-13-48(72)60-45-9-5-8-40-43(45)34-69(55(40)75)46-10-11-47(71)61-54(46)74/h2-9,30-33,46,70H,1,10-29,34-35H2,(H,60,72)(H,59,62,63)(H,61,71,74)","DIBIGUWOQSDFRL-UHFFFAOYSA-N"
"947","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","1118","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","910.356","909.29004654","4.85","65","8","14","3","18","202.06","C46H45ClFN7O10","InChI=1S/C46H45ClFN7O10/c1-2-37(58)53-13-15-54(16-14-53)42-32-26-33(47)38(31-25-28(56)24-27-6-3-4-7-29(27)31)40(48)41(32)51-46(52-42)49-12-17-62-18-19-63-20-21-64-22-23-65-35-9-5-8-30-39(35)45(61)55(44(30)60)34-10-11-36(57)50-43(34)59/h2-9,24-26,34,56H,1,10-23H2,(H,49,51,52)(H,50,57,59)","OPNRFUAEKMDZSI-UHFFFAOYSA-N"
"948","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","575","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","954.409","953.316261288","4.7","68","8","15","3","21","211.29","C48H49ClFN7O11","InChI=1S/C48H49ClFN7O11/c1-2-39(60)55-13-15-56(16-14-55)44-34-28-35(49)40(33-27-30(58)26-29-6-3-4-7-31(29)33)42(50)43(34)53-48(54-44)51-12-17-64-18-19-65-20-21-66-22-23-67-24-25-68-37-9-5-8-32-41(37)47(63)57(46(32)62)36-10-11-38(59)52-45(36)61/h2-9,26-28,36,58H,1,10-25H2,(H,51,53,54)(H,52,59,61)","LWKJTRZIDYEODR-UHFFFAOYSA-N"
"949","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","1606","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","998.462","997.342476036","4.56","71","8","16","3","24","220.52","C50H53ClFN7O12","InChI=1S/C50H53ClFN7O12/c1-2-41(62)57-13-15-58(16-14-57)46-36-30-37(51)42(35-29-32(60)28-31-6-3-4-7-33(31)35)44(52)45(36)55-50(56-46)53-12-17-66-18-19-67-20-21-68-22-23-69-24-25-70-26-27-71-39-9-5-8-34-43(39)49(65)59(48(34)64)38-10-11-40(61)54-47(38)63/h2-9,28-30,38,60H,1,10-27H2,(H,53,55,56)(H,54,61,63)","SGSDFTJNSRZKHC-UHFFFAOYSA-N"
"950","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","104","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","909.372","908.306030952","5.42","65","8","14","4","18","204.86","C46H46ClFN8O9","InChI=1S/C46H46ClFN8O9/c1-2-37(59)54-14-16-55(17-15-54)42-32-26-33(47)38(31-25-28(57)24-27-6-3-4-7-29(27)31)40(48)41(32)52-46(53-42)50-13-19-64-21-23-65-22-20-63-18-12-49-34-9-5-8-30-39(34)45(62)56(44(30)61)35-10-11-36(58)51-43(35)60/h2-9,24-26,35,49,57H,1,10-23H2,(H,50,52,53)(H,51,58,60)","CDECUBDHQJBDTA-UHFFFAOYSA-N"
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"952","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCCN(C)CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","752","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","862.363","861.31653606","6.61","62","8","12","4","14","180.41","C45H45ClFN9O6","InChI=1S/C45H45ClFN9O6/c1-3-36(59)54-19-21-55(22-20-54)41-31-25-32(46)37(30-24-27(57)23-26-9-4-5-10-28(26)30)39(47)40(31)51-45(52-41)49-16-8-18-53(2)17-7-15-48-33-12-6-11-29-38(33)44(62)56(43(29)61)34-13-14-35(58)50-42(34)60/h3-6,9-12,23-25,34,48,57H,1,7-8,13-22H2,2H3,(H,49,51,52)(H,50,58,60)","MAMFJEPMCNQZMY-UHFFFAOYSA-N"
"953","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCN3CCN(CCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","414","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","889.389","888.327435092","5.71","64","9","13","4","12","183.65","C46H46ClFN10O6","InChI=1S/C46H46ClFN10O6/c1-2-37(61)56-20-22-57(23-21-56)42-32-26-33(47)38(31-25-28(59)24-27-6-3-4-7-29(27)31)40(48)41(32)52-46(53-42)50-13-15-55-18-16-54(17-19-55)14-12-49-34-9-5-8-30-39(34)45(64)58(44(30)63)35-10-11-36(60)51-43(35)62/h2-9,24-26,35,49,59H,1,10-23H2,(H,50,52,53)(H,51,60,62)","SDUXHTCBZLYUKP-UHFFFAOYSA-N"
"954","P01116","KRAS G12C","CRBN","","XY-4-88","C=CC(=O)N1CCN(C2=NC(NCCCN3CCN(CCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","79","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","510/4140","Inhibit proliferation of H358/MiaPaCa2 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","917.443","916.35873522","6.42","66","9","13","4","14","183.65","C48H50ClFN10O6","InChI=1S/C48H50ClFN10O6/c1-2-39(63)58-22-24-59(25-23-58)44-34-28-35(49)40(33-27-30(61)26-29-8-3-4-9-31(29)33)42(50)43(34)54-48(55-44)52-15-7-17-57-20-18-56(19-21-57)16-6-14-51-36-11-5-10-32-41(36)47(66)60(46(32)65)37-12-13-38(62)53-45(37)64/h2-5,8-11,26-28,37,51,61H,1,6-7,12-25H2,(H,52,54,55)(H,53,62,64)","HIBGKXYCBQYVSE-UHFFFAOYSA-N"
"955","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCCCN3CCN(CCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","37","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","945.497","944.390035348","7.14","68","9","13","4","16","183.65","C50H54ClFN10O6","InChI=1S/C50H54ClFN10O6/c1-2-41(65)60-24-26-61(27-25-60)46-36-30-37(51)42(35-29-32(63)28-31-10-3-4-11-33(31)35)44(52)45(36)56-50(57-46)54-17-6-8-19-59-22-20-58(21-23-59)18-7-5-16-53-38-13-9-12-34-43(38)49(68)62(48(34)67)39-14-15-40(64)55-47(39)66/h2-4,9-13,28-30,39,53,63H,1,5-8,14-27H2,(H,54,56,57)(H,55,64,66)","UJEVNEOODDVMEG-UHFFFAOYSA-N"
"956","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCN3CCN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","686","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","977.495","976.379864588","5.41","70","9","15","4","18","202.11","C50H54ClFN10O8","InChI=1S/C50H54ClFN10O8/c1-2-41(65)60-18-20-61(21-19-60)46-36-30-37(51)42(35-29-32(63)28-31-6-3-4-7-33(31)35)44(52)45(36)56-50(57-46)54-13-25-70-27-23-59-16-14-58(15-17-59)22-26-69-24-12-53-38-9-5-8-34-43(38)49(68)62(48(34)67)39-10-11-40(64)55-47(39)66/h2-9,28-30,39,53,63H,1,10-27H2,(H,54,56,57)(H,55,64,66)","RYQCTLFDUKDMCW-UHFFFAOYSA-N"
"957","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCOCCOCCNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","1350","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","865.319","864.279816204","5.01","62","8","13","4","15","195.63","C44H42ClFN8O8","InChI=1S/C44H42ClFN8O8/c1-2-36(57)52-13-15-53(16-14-52)40-32-24-33(45)37(30-23-27(55)21-25-5-3-4-6-28(25)30)38(46)39(32)50-44(51-40)48-12-18-62-20-19-61-17-11-47-26-7-8-29-31(22-26)43(60)54(42(29)59)34-9-10-35(56)49-41(34)58/h2-8,21-24,34,47,55H,1,9-20H2,(H,48,50,51)(H,49,56,58)","RFQOMIJEFMXCLB-UHFFFAOYSA-N"
"958","P01116","KRAS G12C","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCCN3CCN(CCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","115","IC50 was tested by displacement of dBET6 from CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.12.006","917.443","916.35873522","5.87","66","9","13","4","14","183.65","C48H50ClFN10O6","InChI=1S/C48H50ClFN10O6/c1-2-40(63)58-21-23-59(24-22-58)44-36-28-37(49)41(34-27-31(61)25-29-7-3-4-8-32(29)34)42(50)43(36)54-48(55-44)52-14-6-16-57-19-17-56(18-20-57)15-5-13-51-30-9-10-33-35(26-30)47(66)60(46(33)65)38-11-12-39(62)53-45(38)64/h2-4,7-10,25-28,38,51,61H,1,5-6,11-24H2,(H,52,54,55)(H,53,62,64)","RETZCVHABXVOBC-UHFFFAOYSA-N"
"959","","BCR-ABL","VHL","","GMB-101","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCNC(=O)C3=CC=CC(C4=CC(NC5=CC=C(OC(F)(F)F)C=C5)=NC=N4)=C3)C(C)(C)C)C=C2)SC=N1","2000","85","Degradation of BCR-ABL in K562 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/0008-5472.CAN-19-1236","888.97","888.324051504","6.17","63","6","12","5","16","197.0","C44H47F3N8O7S","InChI=1S/C44H47F3N8O7S/c1-26-38(63-25-52-26)28-10-8-27(9-11-28)21-49-41(59)35-19-32(56)22-55(35)42(60)39(43(2,3)4)54-37(57)23-61-17-16-48-40(58)30-7-5-6-29(18-30)34-20-36(51-24-50-34)53-31-12-14-33(15-13-31)62-44(45,46)47/h5-15,18,20,24-25,32,35,39,56H,16-17,19,21-23H2,1-4H3,(H,48,58)(H,49,59)(H,54,57)(H,50,51,53)/t32-,35+,39-/m1/s1","DTXGFSWBHDABPE-MNYREFGISA-N"
"960","","BCR-ABL","VHL","","GMB-180","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOC3=CC=CC(C4=CC(NC5=CC=C(OC(F)(F)F)C=C5)=NC=N4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/0008-5472.CAN-19-1236","861.944","861.313152472","6.86","61","6","12","4","16","177.13","C43H46F3N7O7S","InChI=1S/C43H46F3N7O7S/c1-26-38(61-25-50-26)28-10-8-27(9-11-28)21-47-40(56)35-19-31(54)22-53(35)41(57)39(42(2,3)4)52-37(55)23-58-16-17-59-33-7-5-6-29(18-33)34-20-36(49-24-48-34)51-30-12-14-32(15-13-30)60-43(44,45)46/h5-15,18,20,24-25,31,35,39,54H,16-17,19,21-23H2,1-4H3,(H,47,56)(H,52,55)(H,48,49,51)/t31-,35+,39-/m1/s1","JYTRHTWBEBADME-SBJIGXGQSA-N"
"961","","BCR-ABL","VHL","","GMB-475","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOC3=CC=C(C4=CC(NC5=CC=C(OC(F)(F)F)C=C5)=NC=N4)C=C3)C(C)(C)C)C=C2)SC=N1","340","95","Degradation of BCR-ABL in K562 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1000/1110","Inhibit proliferation of K562/BCR-ABL1 transformed Ba/F3 cells","","","","","","","","","","","","","","","10.1158/0008-5472.CAN-19-1236","861.944","861.313152472","6.86","61","6","12","4","16","177.13","C43H46F3N7O7S","InChI=1S/C43H46F3N7O7S/c1-26-38(61-25-50-26)29-7-5-27(6-8-29)21-47-40(56)35-19-31(54)22-53(35)41(57)39(42(2,3)4)52-37(55)23-58-17-18-59-32-13-9-28(10-14-32)34-20-36(49-24-48-34)51-30-11-15-33(16-12-30)60-43(44,45)46/h5-16,20,24-25,31,35,39,54H,17-19,21-23H2,1-4H3,(H,47,56)(H,52,55)(H,48,49,51)/t31-,35+,39-/m1/s1","ONDVWISBMHHLGZ-SBJIGXGQSA-N"
"962","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","933.054","932.373840232","1.68","66","6","15","6","21","264.0","C45H56N8O12S","InChI=1S/C45H56N8O12S/c1-26-38(66-25-49-26)28-10-8-27(9-11-28)21-48-40(58)33-20-29(54)22-52(33)44(62)39(45(2,3)4)50-36(57)24-65-19-17-63-16-18-64-23-35(56)47-15-14-46-31-7-5-6-30-37(31)43(61)53(42(30)60)32-12-13-34(55)51-41(32)59/h5-11,25,29,32-33,39,46,54H,12-24H2,1-4H3,(H,47,56)(H,48,58)(H,50,57)(H,51,55,59)/t29-,32?,33+,39-/m1/s1","XNOQLGGYTGYXMS-CYWWUHAWSA-N"
"963","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","977.107","976.40005498","1.53","69","6","16","6","24","273.23","C47H60N8O13S","InChI=1S/C47H60N8O13S/c1-28-40(69-27-51-28)30-10-8-29(9-11-30)23-50-42(60)35-22-31(56)24-54(35)46(64)41(47(2,3)4)52-38(59)26-68-21-19-66-17-16-65-18-20-67-25-37(58)49-15-14-48-33-7-5-6-32-39(33)45(63)55(44(32)62)34-12-13-36(57)53-43(34)61/h5-11,27,31,34-35,41,48,56H,12-26H2,1-4H3,(H,49,58)(H,50,60)(H,52,59)(H,53,57,61)/t31-,34?,35+,41-/m1/s1","PZABRRMYRKEELG-MQKNCPGISA-N"
"964","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1021.16","1020.42626973","1.38","72","6","17","6","27","282.46","C49H64N8O14S","InChI=1S/C49H64N8O14S/c1-30-42(72-29-53-30)32-10-8-31(9-11-32)25-52-44(62)37-24-33(58)26-56(37)48(66)43(49(2,3)4)54-40(61)28-71-23-21-69-19-17-67-16-18-68-20-22-70-27-39(60)51-15-14-50-35-7-5-6-34-41(35)47(65)57(46(34)64)36-12-13-38(59)55-45(36)63/h5-11,29,33,36-37,43,50,58H,12-28H2,1-4H3,(H,51,60)(H,52,62)(H,54,61)(H,55,59,63)/t33-,36?,37+,43-/m1/s1","CGJFILRPTIZAOW-LRLCZACISA-N"
"965","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1065.213","1064.45248448","1.24","75","6","18","6","30","291.69","C51H68N8O15S","InChI=1S/C51H68N8O15S/c1-32-44(75-31-55-32)34-10-8-33(9-11-34)27-54-46(64)39-26-35(60)28-58(39)50(68)45(51(2,3)4)56-42(63)30-74-25-23-72-21-19-70-17-16-69-18-20-71-22-24-73-29-41(62)53-15-14-52-37-7-5-6-36-43(37)49(67)59(48(36)66)38-12-13-40(61)57-47(38)65/h5-11,31,35,38-39,45,52,60H,12-30H2,1-4H3,(H,53,62)(H,54,64)(H,56,63)(H,57,61,65)/t35-,38?,39+,45-/m1/s1","RYUOWYBJHFPQOX-UTKYEEBISA-N"
"966","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1197.372","1196.53112872","0.79","84","6","21","6","39","319.38","C57H80N8O18S","InChI=1S/C57H80N8O18S/c1-38-50(84-37-61-38)40-10-8-39(9-11-40)33-60-52(70)45-32-41(66)34-64(45)56(74)51(57(2,3)4)62-48(69)36-83-31-29-81-27-25-79-23-21-77-19-17-75-16-18-76-20-22-78-24-26-80-28-30-82-35-47(68)59-15-14-58-43-7-5-6-42-49(43)55(73)65(54(42)72)44-12-13-46(67)63-53(44)71/h5-11,37,41,44-45,51,58,66H,12-36H2,1-4H3,(H,59,68)(H,60,70)(H,62,69)(H,63,67,71)/t41-,44?,45+,51-/m1/s1","QGVXLBFFRLCUDW-UWSMTTORSA-N"
"967","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","945.109","944.41022574","3.25","67","6","14","6","22","254.77","C47H60N8O11S","InChI=1S/C47H60N8O11S/c1-28-40(67-27-51-28)30-14-12-29(13-15-30)23-50-42(60)35-22-31(56)24-54(35)46(64)41(47(2,3)4)52-38(59)26-66-21-8-6-5-7-20-65-25-37(58)49-19-18-48-33-11-9-10-32-39(33)45(63)55(44(32)62)34-16-17-36(57)53-43(34)61/h9-15,27,31,34-35,41,48,56H,5-8,16-26H2,1-4H3,(H,49,58)(H,50,60)(H,52,59)(H,53,57,61)/t31-,34?,35+,41-/m1/s1","DSSCNRUEBUIXKS-MQKNCPGISA-N"
"968","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCOCCCCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","200/230","75/98","Degradation of CRBN in HeLa/HEK293 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1061.269","1060.49395536","3.67","75","6","16","6","30","273.23","C53H72N8O13S","InChI=1S/C53H72N8O13S/c1-34-46(75-33-57-34)36-16-14-35(15-17-36)29-56-48(66)41-28-37(62)30-60(41)52(70)47(53(2,3)4)58-44(65)32-74-25-10-6-8-23-72-27-26-71-22-7-5-9-24-73-31-43(64)55-21-20-54-39-13-11-12-38-45(39)51(69)61(50(38)68)40-18-19-42(63)59-49(40)67/h11-17,33,37,40-41,47,54,62H,5-10,18-32H2,1-4H3,(H,55,64)(H,56,66)(H,58,65)(H,59,63,67)/t37-,40?,41+,47-/m1/s1","PEZCAXDTKNFUCR-CTMFSBKBSA-N"
"969","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1021.135","1020.40628323","2.34","72","7","16","6","24","273.23","C49H61FN8O13S","InChI=1S/C49H61FN8O13S/c1-28-40(72-27-54-28)29-8-9-30(24-53-42(62)35-23-31(59)25-57(35)46(66)41(48(2,3)4)56-47(67)49(50)12-13-49)36(22-29)71-21-20-69-17-16-68-18-19-70-26-38(61)52-15-14-51-33-7-5-6-32-39(33)45(65)58(44(32)64)34-10-11-37(60)55-43(34)63/h5-9,22,27,31,34-35,41,51,59H,10-21,23-26H2,1-4H3,(H,52,61)(H,53,62)(H,56,67)(H,55,60,63)/t31-,34?,35+,41-/m1/s1","TXCXPPPSDJWMNI-MQKNCPGISA-N"
"970","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCOCCOCCOCCOCCOCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","1109.241","1108.45871273","2.04","78","7","18","6","30","291.69","C53H69FN8O15S","InChI=1S/C53H69FN8O15S/c1-32-44(78-31-58-32)33-8-9-34(28-57-46(66)39-27-35(63)29-61(39)50(70)45(52(2,3)4)60-51(71)53(54)12-13-53)40(26-33)77-25-24-75-21-20-73-17-16-72-18-19-74-22-23-76-30-42(65)56-15-14-55-37-7-5-6-36-43(37)49(69)62(48(36)68)38-10-11-41(64)59-47(38)67/h5-9,26,31,35,38-39,45,55,63H,10-25,27-30H2,1-4H3,(H,56,65)(H,57,66)(H,60,71)(H,59,64,67)/t35-,38?,39+,45-/m1/s1","LWFPDHHBRFLHRB-UTKYEEBISA-N"
"971","Q96SW2","CRBN","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCCC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2019.02.048","931.057","930.37458918","3.4","66","7","13","6","18","245.54","C46H55FN8O10S","InChI=1S/C46H55FN8O10S/c1-25-37(66-24-51-25)26-11-12-27(22-50-39(59)32-21-28(56)23-54(32)43(63)38(45(2,3)4)53-44(64)46(47)15-16-46)33(20-26)65-19-6-5-10-34(57)49-18-17-48-30-9-7-8-29-36(30)42(62)55(41(29)61)31-13-14-35(58)52-40(31)60/h7-9,11-12,20,24,28,31-32,38,48,56H,5-6,10,13-19,21-23H2,1-4H3,(H,49,57)(H,50,59)(H,53,64)(H,52,58,60)/t28-,31?,32+,38-/m1/s1","FDXZMKIGERUKNS-LDYGXKOKSA-N"
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"975","P62942","FKBP12","CRBN","","RC32","CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCOCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C","0.27","","Degradation of FKBP12 in Jurkat cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41421-018-0079-1","1426.71","1425.75708882","5.78","102","8","24","4","23","338.41","C75H107N7O20","InChI=1S/C75H107N7O20/c1-45-17-12-11-13-18-46(2)61(94-8)41-54-24-22-51(7)75(93,102-54)69(87)73(91)81-29-15-14-21-58(81)74(92)101-62(42-59(83)47(3)38-50(6)67(86)68(96-10)66(85)49(5)37-45)48(4)39-52-23-26-60(63(40-52)95-9)100-36-35-99-44-53-43-80(79-78-53)30-32-98-34-33-97-31-28-76-56-20-16-19-55-65(56)72(90)82(71(55)89)57-25-27-64(84)77-70(57)88/h11-13,16-20,38,43,45,47-49,51-52,54,57-58,60-63,67-68,76,86,93H,14-15,21-37,39-42,44H2,1-10H3,(H,77,84,88)/b13-11+,17-12+,46-18+,50-38+/t45-,47-,48-,49-,51-,52+,54+,57?,58+,60-,61+,62+,63-,67-,68+,75-/m1/s1","XCSUEITWRRFFMN-SJQMKIJVSA-N"
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"977","O43353","RIPK2","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOCCOCCOC3=CC4=NC=CC(NC5=CC=C6SC=NC6=C5)=C4C=C3S(=O)(=O)C(C)(C)C)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","0.4","","Degradation of RIPK2 in THP-1 cells after 18 h treatment","","","10","IC50 of RIPK2 was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-020-0868-6","1092.395","1091.48603354","7.7","77","8","15","4","23","208.64","C58H73N7O10S2","InChI=1S/C58H73N7O10S2/c1-37(59-8)54(66)64-53(57(2,3)4)56(68)65-35-40-30-42(18-16-39(40)31-49(65)55(67)63-45-15-11-13-38-12-9-10-14-43(38)45)74-28-26-72-24-22-71-23-25-73-27-29-75-50-34-47-44(33-52(50)77(69,70)58(5,6)7)46(20-21-60-47)62-41-17-19-51-48(32-41)61-36-76-51/h9-10,12,14,16-21,30,32-34,36-37,45,49,53,59H,11,13,15,22-29,31,35H2,1-8H3,(H,60,62)(H,63,67)(H,64,66)/t37-,45+,49-,53+/m0/s1","QEZBEUBDCKYYAV-ORFCTVBLSA-N"
"978","O43353","RIPK2","CRBN","","","CC(C)(C)S(=O)(=O)C1=CC2=C(NC3=CC=C4SC=NC4=C3)C=CN=C2C=C1OCCOCCOCCOCCOCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","2.5","","Degradation of RIPK2 in THP-1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-020-0868-6","889.022","888.282248356","2.95","62","7","15","3","20","213.68","C43H48N6O11S2","InChI=1S/C43H48N6O11S2/c1-43(2,3)62(54,55)38-22-29-32(46-27-7-9-37-34(21-27)45-26-61-37)11-12-44-33(29)23-36(38)60-20-19-58-16-15-56-13-14-57-17-18-59-25-40(51)47-31-6-4-5-28-30(31)24-49(42(28)53)35-8-10-39(50)48-41(35)52/h4-7,9,11-12,21-23,26,35H,8,10,13-20,24-25H2,1-3H3,(H,44,46)(H,47,51)(H,48,50,52)","BRZGXSNAXRPPFI-UHFFFAOYSA-N"
"979","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCN(CCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","12.6","69.2","Degradation of RIPK2 in hPBMC cells after 24 h treatment","","","251.2","IC50 of RIPK2 was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-020-0868-6","1093.326","1092.45861064","5.19","77","9","18","4","17","253.83","C53H65FN14O7S2","InChI=1S/C53H65FN14O7S2/c1-31-32(2)63-64-46(31)62-47-38-25-43(77(73,74)53(4,5)6)42(26-39(38)58-30-59-47)75-24-23-65-19-21-67(22-20-65)52-56-27-36(28-57-52)50(71)66-17-14-34(15-18-66)44(61-48(70)33(3)55-7)51(72)68-16-8-9-41(68)49-60-40(29-76-49)45(69)35-10-12-37(54)13-11-35/h10-13,25-30,33-34,41,44,55H,8-9,14-24H2,1-7H3,(H,61,70)(H2,58,59,62,63,64)/t33-,41-,44-/m0/s1","HZMQXNZSFFXKMT-LCPJFFRWSA-N"
"979","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCN(CCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1093.326","1092.45861064","5.19","77","9","18","4","17","253.83","C53H65FN14O7S2","InChI=1S/C53H65FN14O7S2/c1-31-32(2)63-64-46(31)62-47-38-25-43(77(73,74)53(4,5)6)42(26-39(38)58-30-59-47)75-24-23-65-19-21-67(22-20-65)52-56-27-36(28-57-52)50(71)66-17-14-34(15-18-66)44(61-48(70)33(3)55-7)51(72)68-16-8-9-41(68)49-60-40(29-76-49)45(69)35-10-12-37(54)13-11-35/h10-13,25-30,33-34,41,44,55H,8-9,14-24H2,1-7H3,(H,61,70)(H2,58,59,62,63,64)/t33-,41-,44-/m0/s1","HZMQXNZSFFXKMT-LCPJFFRWSA-N"
"980","O43353","RIPK2","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","0.4","94.3","Degradation of RIPK2 in hPBMC cells after 24 h treatment","","","10","IC50 of RIPK2 was tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s42003-020-0868-6","1045.232","1044.49276789","4.73","74","7","16","6","17","261.76","C50H66F2N14O7S","InChI=1S/C50H66F2N14O7S/c1-28-29(2)62-63-43(28)61-44-32-22-39(74(71,72)50(7,8)9)38(23-35(32)56-27-57-44)73-20-12-15-64-16-18-65(19-17-64)40-25-54-36(24-55-40)46(68)58-31-21-37(47(69)59-41-33(51)13-11-14-34(41)52)66(26-31)48(70)42(49(4,5)6)60-45(67)30(3)53-10/h11,13-14,22-25,27,30-31,37,42,53H,12,15-21,26H2,1-10H3,(H,58,68)(H,59,69)(H,60,67)(H2,56,57,61,62,63)/t30-,31-,37-,42+/m0/s1","CHNBEZLJAQUZEX-LFRONEFISA-N"
"980","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)C[C@H]1C(=O)NC1=C(F)C=CC=C1F)C(C)(C)C","0.79","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","10","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.16","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1045.232","1044.49276789","4.73","74","7","16","6","17","261.76","C50H66F2N14O7S","InChI=1S/C50H66F2N14O7S/c1-28-29(2)62-63-43(28)61-44-32-22-39(74(71,72)50(7,8)9)38(23-35(32)56-27-57-44)73-20-12-15-64-16-18-65(19-17-64)40-25-54-36(24-55-40)46(68)58-31-21-37(47(69)59-41-33(51)13-11-14-34(41)52)66(26-31)48(70)42(49(4,5)6)60-45(67)30(3)53-10/h11,13-14,22-25,27,30-31,37,42,53H,12,15-21,26H2,1-10H3,(H,58,68)(H,59,69)(H,60,67)(H2,56,57,61,62,63)/t30-,31-,37-,42+/m0/s1","CHNBEZLJAQUZEX-LFRONEFISA-N"
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"988","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCC(=O)NCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","844.106","842.196037172","1.59","56","4","14","5","22","245.58","C34H41Cl3N8O11","InChI=1S/C34H41Cl3N8O11/c35-34(36,37)31(43-32-40-11-2-12-41-32)44-33(52)56-16-4-14-39-25(47)10-18-54-20-19-53-17-9-24(46)38-13-3-15-55-23-6-1-5-21-27(23)30(51)45(29(21)50)22-7-8-26(48)42-28(22)49/h1-2,5-6,11-12,22,31H,3-4,7-10,13-20H2,(H,38,46)(H,39,47)(H,44,52)(H,40,41,43)(H,42,48,49)","OBXCLKADXRRJDC-UHFFFAOYSA-N"
"989","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCC(=O)NCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","888.159","886.22225192","1.44","59","4","15","5","25","254.81","C36H45Cl3N8O12","InChI=1S/C36H45Cl3N8O12/c37-36(38,39)33(45-34-42-11-2-12-43-34)46-35(54)59-16-4-14-41-27(49)10-18-56-20-22-57-21-19-55-17-9-26(48)40-13-3-15-58-25-6-1-5-23-29(25)32(53)47(31(23)52)24-7-8-28(50)44-30(24)51/h1-2,5-6,11-12,24,33H,3-4,7-10,13-22H2,(H,40,48)(H,41,49)(H,46,54)(H,42,43,45)(H,44,50,51)","HLSBEOSHTGTABM-UHFFFAOYSA-N"
"990","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCOCCOCCC(=O)NCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","976.265","974.274681416","1.15","65","4","17","5","31","273.27","C40H53Cl3N8O14","InChI=1S/C40H53Cl3N8O14/c41-40(42,43)37(49-38-46-11-2-12-47-38)50-39(58)65-16-4-14-45-31(53)10-18-60-20-22-62-24-26-63-25-23-61-21-19-59-17-9-30(52)44-13-3-15-64-29-6-1-5-27-33(29)36(57)51(35(27)56)28-7-8-32(54)48-34(28)55/h1-2,5-6,11-12,28,37H,3-4,7-10,13-26H2,(H,44,52)(H,45,53)(H,50,58)(H,46,47,49)(H,48,54,55)","NVELIQOYHHKOQA-UHFFFAOYSA-N"
"991","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","874.132","872.206601856","1.09","58","4","15","5","24","254.81","C35H43Cl3N8O12","InChI=1S/C35H43Cl3N8O12/c36-35(37,38)32(44-33-41-10-2-11-42-33)45-34(53)58-14-3-12-39-25(47)8-15-54-18-20-56-21-19-55-16-9-26(48)40-13-17-57-24-5-1-4-22-28(24)31(52)46(30(22)51)23-6-7-27(49)43-29(23)50/h1-2,4-5,10-11,23,32H,3,6-9,12-21H2,(H,39,47)(H,40,48)(H,45,53)(H,41,42,44)(H,43,49,50)","HBCLVNBUEBFKDO-UHFFFAOYSA-N"
"992","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCOCCOCCOCCC(=O)NCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","1006.291","1004.2852461","0.64","67","4","18","5","33","282.5","C41H55Cl3N8O15","InChI=1S/C41H55Cl3N8O15/c42-41(43,44)38(50-39-47-10-2-11-48-39)51-40(59)67-14-3-12-45-31(53)8-15-60-18-20-62-22-24-64-26-27-65-25-23-63-21-19-61-16-9-32(54)46-13-17-66-30-5-1-4-28-34(30)37(58)52(36(28)57)29-6-7-33(55)49-35(29)56/h1-2,4-5,10-11,29,38H,3,6-9,12-27H2,(H,45,53)(H,46,54)(H,51,59)(H,47,48,50)(H,49,55,56)","OOBSQTYLVVHJOE-UHFFFAOYSA-N"
"993","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCOCCOCCOCCC(=O)NCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","1020.318","1018.30089616","1.0","68","4","18","5","34","282.5","C42H57Cl3N8O15","InChI=1S/C42H57Cl3N8O15/c43-42(44,45)39(51-40-48-11-2-12-49-40)52-41(60)68-16-4-14-47-33(55)10-18-62-20-22-64-24-26-66-28-27-65-25-23-63-21-19-61-17-9-32(54)46-13-3-15-67-31-6-1-5-29-35(31)38(59)53(37(29)58)30-7-8-34(56)50-36(30)57/h1-2,5-6,11-12,30,39H,3-4,7-10,13-28H2,(H,46,54)(H,47,55)(H,52,60)(H,48,49,51)(H,50,56,57)","GLTZKDTXKLJDMO-UHFFFAOYSA-N"
"994","Q12834","Cdc20","CRBN","","","O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ebiom.2019.10.013","1152.477","1150.37954041","0.56","77","4","21","5","43","310.19","C48H69Cl3N8O18","InChI=1S/C48H69Cl3N8O18/c49-48(50,51)45(57-46-54-11-2-12-55-46)58-47(66)77-16-4-14-53-39(61)10-18-68-20-22-70-24-26-72-28-30-74-32-34-75-33-31-73-29-27-71-25-23-69-21-19-67-17-9-38(60)52-13-3-15-76-37-6-1-5-35-41(37)44(65)59(43(35)64)36-7-8-40(62)56-42(36)63/h1-2,5-6,11-12,36,45H,3-4,7-10,13-34H2,(H,52,60)(H,53,61)(H,58,66)(H,54,55,57)(H,56,62,63)","HJELEGKBOWOUAV-UHFFFAOYSA-N"
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"996","P40337","VHL","VHL","","CM09","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41","ITC in pVHL19","","","-10.3","-6.9","-3.5","ITC in pVHL19","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-017-00954-1","1091.364","1090.48676181","3.86","76","6","16","6","25","260.18","C54H74N8O12S2","InChI=1S/C54H74N8O12S2/c1-33-45(75-31-57-33)37-13-9-35(10-14-37)25-55-49(67)41-23-39(63)27-61(41)51(69)47(53(3,4)5)59-43(65)29-73-21-19-71-17-18-72-20-22-74-30-44(66)60-48(54(6,7)8)52(70)62-28-40(64)24-42(62)50(68)56-26-36-11-15-38(16-12-36)46-34(2)58-32-76-46/h9-16,31-32,39-42,47-48,63-64H,17-30H2,1-8H3,(H,55,67)(H,56,68)(H,59,65)(H,60,66)/t39-,40-,41+,42+,47-,48-/m1/s1","DGEQVVMYDYQSBA-OEANBFCYSA-N"
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"1005","Q16288","TRKC","MDM2","","IY-IY-PEG5-nutlin","CC[C@H](C)[C@H](N)C1=CN([C@@H](CC2=CC=C(O)C=C2)C(=O)N2CCN(C3=NC(NCCOCCOCCOCC4=CN(CCOCCOCCOCCOCCOCCNC(=O)CN5CCN(C(=O)N6C(C7=CC=C(OC)C=C7OC(C)C)=N[C@@H](C7=CC=C(Cl)C=C7)[C@H]6C6=CC=C(Cl)C=C6)CC5=O)N=N4)=NC(N4CCN(C(=O)[C@H](CC5=CC=C(O)C=C5)N5C=C([C@@H](N)[C@@H](C)CC)N=N5)CC4)=N3)CC2)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.molpharmaceut.9b00673","1963.153","1960.94228406","5.99","139","13","35","6","54","460.05","C96H130Cl2N24O17","InChI=1S/C96H130Cl2N24O17/c1-8-66(5)86(99)79-60-120(111-108-79)81(56-68-10-22-75(123)23-11-68)91(127)113-30-34-115(35-31-113)94-104-93(105-95(106-94)116-36-32-114(33-37-116)92(128)82(57-69-12-24-76(124)25-13-69)121-61-80(109-112-121)87(100)67(6)9-2)102-29-42-132-45-48-137-54-55-138-64-74-59-119(110-107-74)40-43-133-46-49-135-51-53-136-52-50-134-47-44-131-41-28-101-84(125)62-117-38-39-118(63-85(117)126)96(129)122-89(71-16-20-73(98)21-17-71)88(70-14-18-72(97)19-15-70)103-90(122)78-27-26-77(130-7)58-83(78)139-65(3)4/h10-27,58-61,65-67,81-82,86-89,123-124H,8-9,28-57,62-64,99-100H2,1-7H3,(H,101,125)(H,102,104,105,106)/t66-,67-,81-,82-,86-,87-,88-,89+/m0/s1","DVJPBSSBZSLKFD-LMBYOWTGSA-N"
"1006","P29373","CRABP-II","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCNC(=O)CO/N=C1\CCC(C)(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)=C1C)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","","","","","","","","",""," ","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2012.04.134","1062.363","1061.62014186","6.09","77","5","11","6","28","226.09","C60H83N7O10","InChI=1S/C60H83N7O10/c1-41(19-17-20-42(2)39-52(69)70)28-29-48-43(3)49(30-31-60(48,5)6)66-77-40-51(68)62-32-35-75-37-38-76-36-33-63-58(73)55(53(45-21-11-8-12-22-45)46-23-13-9-14-24-46)65-57(72)50-27-18-34-67(50)59(74)54(47-25-15-10-16-26-47)64-56(71)44(4)61-7/h8-9,11-14,17,19-24,28-29,39,44,47,50,53-55,61H,10,15-16,18,25-27,30-38,40H2,1-7H3,(H,62,68)(H,63,73)(H,64,71)(H,65,72)(H,69,70)/b20-17+,29-28+,41-19+,42-39+,66-49+/t44-,50-,54-,55-/m0/s1","JKPIDKPKBOTXBU-HMLGKSOISA-N"
"1007","Q9UBN7","HDAC6","CRBN","","NP6","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCN4C=C(CCCCN(CC5=CC=C(C(=O)NO)C=C5)C(=O)NC5=CC=CC=C5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1007/s13238-018-0602-z","751.801","751.307809272","2.08","55","6","12","5","17","217.19","C38H41N9O8","InChI=1S/C38H41N9O8/c48-32-17-16-31(35(50)41-32)47-36(51)29-10-6-11-30(33(29)37(47)52)39-18-21-55-22-20-46-24-28(42-44-46)9-4-5-19-45(38(53)40-27-7-2-1-3-8-27)23-25-12-14-26(15-13-25)34(49)43-54/h1-3,6-8,10-15,24,31,39,54H,4-5,9,16-23H2,(H,40,53)(H,43,49)(H,41,48,50)","UJRLEVAAONZHJL-UHFFFAOYSA-N"
"1008","Q9UBN7","HDAC6","CRBN","","NP8","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCN4C=C(CCCCN(CC5=CC=C(C(=O)NO)C=C5)C(=O)NC5=CC=CC=C5)N=N4)=C3C2=O)C(=O)N1","3.8","","Degradation of HADC6 in MM.1S cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1210","Inhibit viability of MM.1S cells","","","","","","","","","","","10.1007/s13238-018-0602-z","795.854","795.33402402","1.94","58","6","13","5","20","226.42","C40H45N9O9","InChI=1S/C40H45N9O9/c50-34-17-16-33(37(52)43-34)49-38(53)31-10-6-11-32(35(31)39(49)54)41-18-21-57-23-24-58-22-20-48-26-30(44-46-48)9-4-5-19-47(40(55)42-29-7-2-1-3-8-29)25-27-12-14-28(15-13-27)36(51)45-56/h1-3,6-8,10-15,26,33,41,56H,4-5,9,16-25H2,(H,42,55)(H,45,51)(H,43,50,52)","NLVMRCQAKUCFIA-UHFFFAOYSA-N"
"1009","Q9UBN7","HDAC6","CRBN","","NP9","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4C=C(CCCCN(CC5=CC=C(C(=O)NO)C=C5)C(=O)NC5=CC=CC=C5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1007/s13238-018-0602-z","839.907","839.360238768","1.79","61","6","14","5","23","235.65","C42H49N9O10","InChI=1S/C42H49N9O10/c52-36-17-16-35(39(54)45-36)51-40(55)33-10-6-11-34(37(33)41(51)56)43-18-21-59-23-25-61-26-24-60-22-20-50-28-32(46-48-50)9-4-5-19-49(42(57)44-31-7-2-1-3-8-31)27-29-12-14-30(15-13-29)38(53)47-58/h1-3,6-8,10-15,28,35,43,58H,4-5,9,16-27H2,(H,44,57)(H,47,53)(H,45,52,54)","NLRSDLYNFKXJTK-UHFFFAOYSA-N"
"1010","Q9UBN7","HDAC6","CRBN","","NP10","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCN4C=C(CCCCN(CC5=CC=C(C(=O)NO)C=C5)C(=O)NC5=CC=CC=C5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1007/s13238-018-0602-z","883.96","883.386453516","1.64","64","6","15","5","26","244.88","C44H53N9O11","InChI=1S/C44H53N9O11/c54-38-17-16-37(41(56)47-38)53-42(57)35-10-6-11-36(39(35)43(53)58)45-18-21-61-23-25-63-27-28-64-26-24-62-22-20-52-30-34(48-50-52)9-4-5-19-51(44(59)46-33-7-2-1-3-8-33)29-31-12-14-32(15-13-31)40(55)49-60/h1-3,6-8,10-15,30,37,45,60H,4-5,9,16-29H2,(H,46,59)(H,49,55)(H,47,54,56)","BNXXGUIHXGSVEJ-UHFFFAOYSA-N"
"1011","Q96SW2","CRBN","VHL","","TD-158","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","44.5","97.1","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","842.032","841.38328272","5.37","60","6","11","5","17","207.21","C44H55N7O8S","InChI=1S/C44H55N7O8S/c1-26-37(60-25-47-26)28-17-15-27(16-18-28)23-46-39(55)33-22-29(52)24-50(33)43(59)38(44(2,3)4)48-34(53)14-9-7-5-6-8-10-21-45-31-13-11-12-30-36(31)42(58)51(41(30)57)32-19-20-35(54)49-40(32)56/h11-13,15-18,25,29,32-33,38,45,52H,5-10,14,19-24H2,1-4H3,(H,46,55)(H,48,53)(H,49,54,56)/t29-,32?,33+,38-/m1/s1","UQJOJHWASBETAR-PHPCURKRSA-N"
"1012","Q96SW2","CRBN","VHL","","TD-165","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","20.4","99.6","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","870.086","869.414582848","6.46","62","6","11","5","19","207.21","C46H59N7O8S","InChI=1S/C46H59N7O8S/c1-28-39(62-27-49-28)30-19-17-29(18-20-30)25-48-41(57)35-24-31(54)26-52(35)45(61)40(46(2,3)4)50-36(55)16-11-9-7-5-6-8-10-12-23-47-33-15-13-14-32-38(33)44(60)53(43(32)59)34-21-22-37(56)51-42(34)58/h13-15,17-20,27,31,34-35,40,47,54H,5-12,16,21-26H2,1-4H3,(H,48,57)(H,50,55)(H,51,56,58)/t31-,34?,35+,40-/m1/s1","KSXVXTSIDVRZBR-IINAPWRYSA-N"
"1013","Q96SW2","CRBN","VHL","","TD-156","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","100.6","96.9","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","813.978","813.351982592","4.29","58","6","11","5","15","207.21","C42H51N7O8S","InChI=1S/C42H51N7O8S/c1-24-35(58-23-45-24)26-15-13-25(14-16-26)21-44-37(53)31-20-27(50)22-48(31)41(57)36(42(2,3)4)46-32(51)12-7-5-6-8-19-43-29-11-9-10-28-34(29)40(56)49(39(28)55)30-17-18-33(52)47-38(30)54/h9-11,13-16,23,27,30-31,36,43,50H,5-8,12,17-22H2,1-4H3,(H,44,53)(H,46,51)(H,47,52,54)/t27-,30?,31+,36-/m1/s1","NONAQRYFKJIZQD-AEXNMDALSA-N"
"1014","Q96SW2","CRBN","VHL","","TD-759","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","28.8","98.4","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","927.138","926.436046564","5.8","66","6","12","6","21","236.31","C48H62N8O9S","InChI=1S/C48H62N8O9S/c1-29-41(66-28-52-29)31-19-17-30(18-20-31)25-51-43(61)36-24-32(57)27-55(36)47(65)42(48(2,3)4)53-37(58)16-11-9-7-5-6-8-10-12-23-49-39(60)26-50-34-15-13-14-33-40(34)46(64)56(45(33)63)35-21-22-38(59)54-44(35)62/h13-15,17-20,28,32,35-36,42,50,57H,5-12,16,21-27H2,1-4H3,(H,49,60)(H,51,61)(H,53,58)(H,54,59,62)/t32-,35?,36+,42-/m1/s1","FWZROUMFDYURRM-FYESNEIGSA-N"
"1015","Q96SW2","CRBN","VHL","","TD-760","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","367.7","82","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","928.122","927.420062152","5.24","66","6","12","5","21","233.51","C48H61N7O10S","InChI=1S/C48H61N7O10S/c1-29-41(66-28-51-29)31-19-17-30(18-20-31)25-50-43(60)35-24-32(56)26-54(35)47(64)42(48(2,3)4)52-37(57)16-11-9-7-5-6-8-10-12-23-49-39(59)27-65-36-15-13-14-33-40(36)46(63)55(45(33)62)34-21-22-38(58)53-44(34)61/h13-15,17-20,28,32,34-35,42,56H,5-12,16,21-27H2,1-4H3,(H,49,59)(H,50,60)(H,52,57)(H,53,58,61)/t32-,34?,35+,42-/m1/s1","NANCWGWHLCCPLL-MSVILSSVSA-N"
"1016","Q96SW2","CRBN","VHL","","TD-033","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C(C)(C)C)C=C2)SC=N1","2546.1","77.9","Degradation of CRBN in HEK293T cells after 24h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41598-019-56177-5","827.961","827.331247148","3.06","59","6","11","5","14","224.28","C42H49N7O9S","InChI=1S/C42H49N7O9S/c1-23-35(59-22-44-23)25-15-13-24(14-16-25)20-43-37(54)30-19-26(50)21-48(30)41(58)36(42(2,3)4)46-32(52)12-7-5-6-11-31(51)45-28-10-8-9-27-34(28)40(57)49(39(27)56)29-17-18-33(53)47-38(29)55/h8-10,13-16,22,26,29-30,36,50H,5-7,11-12,17-21H2,1-4H3,(H,43,54)(H,45,51)(H,46,52)(H,47,53,55)/t26-,29?,30+,36-/m1/s1","ZBCXOELGHROVDK-FOLICCEFSA-N"
"1017","","BCR-ABL","IAP","","SNIPER(ABL)-49","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)COCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC4=CC=CC=C4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1","100000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","959.162","958.506509072","3.41","70","6","14","6","26","235.49","C52H66N10O8","InChI=1S/C52H66N10O8/c1-36(2)30-46(58-51(67)48(64)43(53)31-38-8-5-4-6-9-38)50(66)55-20-25-68-26-27-69-28-29-70-35-47(63)62-23-21-61(22-24-62)34-39-12-14-40(15-13-39)49(65)57-42-16-11-37(3)45(32-42)60-52-56-19-17-44(59-52)41-10-7-18-54-33-41/h4-19,32-33,36,43,46,48,64H,20-31,34-35,53H2,1-3H3,(H,55,66)(H,57,65)(H,58,67)(H,56,59,60)/t43-,46+,48+/m1/s1","JBCHWUPJETZFEN-RGTBTGBSSA-N"
"1018","","BCR-ABL","IAP","","SNIPER(ABL)-13","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCCOCCNC(=O)C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1","20000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","839.913","839.382946284","4.6","60","4","12","6","25","208.28","C42H52F3N7O8","InChI=1S/C42H52F3N7O8/c1-28(2)23-36(52-41(56)38(53)34(46)24-29-7-4-3-5-8-29)40(55)48-16-18-58-20-22-59-21-19-57-17-15-47-39(54)31-10-6-9-30(25-31)35-26-37(50-27-49-35)51-32-11-13-33(14-12-32)60-42(43,44)45/h3-14,25-28,34,36,38,53H,15-24,46H2,1-2H3,(H,47,54)(H,48,55)(H,52,56)(H,49,50,51)/t34-,36+,38+/m1/s1","QPZIGDUURVIUPV-IJDZGJQBSA-N"
"1019","","BCR-ABL","IAP","","SNIPER(ABL)-44","CCN1CCN(CC2=CC=C(NC(=O)C3=CC=CC(C4=CC=C5N=C(NC(=O)COCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC6=CC=CC=C6)SC5=N4)=C3)C=C2C(F)(F)F)CC1","10000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1020.189","1019.45506567","4.98","72","6","14","6","26","222.6","C51H64F3N9O8S","InChI=1S/C51H64F3N9O8S/c1-4-62-18-20-63(21-19-62)31-37-13-14-38(30-39(37)51(52,53)54)57-46(66)36-12-8-11-35(29-36)41-15-16-42-49(59-41)72-50(60-42)61-44(64)32-71-26-25-70-24-23-69-22-17-56-47(67)43(27-33(2)3)58-48(68)45(65)40(55)28-34-9-6-5-7-10-34/h5-16,29-30,33,40,43,45,65H,4,17-28,31-32,55H2,1-3H3,(H,56,67)(H,57,66)(H,58,68)(H,60,61,64)/t40-,43+,45+/m1/s1","QRGLWQMXPLDUPI-XMNZJGRJSA-N"
"1020","","BCR-ABL","IAP","","SNIPER(ABL)-20","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)COCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC3=CC=CC=C3)CC2)=N1",">100000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","923.538","922.392657528","4.16","64","5","15","6","24","235.49","C44H59ClN10O8S","InChI=1S/C44H59ClN10O8S/c1-28(2)23-34(51-43(60)40(57)33(46)24-31-10-6-5-7-11-31)41(58)47-13-18-61-19-20-62-21-22-63-27-38(56)55-16-14-54(15-17-55)37-25-36(49-30(4)50-37)52-44-48-26-35(64-44)42(59)53-39-29(3)9-8-12-32(39)45/h5-12,25-26,28,33-34,40,57H,13-24,27,46H2,1-4H3,(H,47,58)(H,51,60)(H,53,59)(H,48,49,50,52)/t33-,34+,40+/m1/s1","YYNXYOVXFJJJHD-OCIHUODESA-N"
"1021","","BCR-ABL","IAP","","SNIPER(ABL)-50","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCC(=O)N1CCN(CC2=CC=C(C(=O)NC3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3)C=C2)CC1)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1",">100000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1213.495","1212.64842227","6.47","89","9","15","6","29","250.68","C68H84N12O9","InChI=1S/C68H84N12O9/c1-47-23-28-55(43-57(47)75-68-72-31-29-56(74-68)54-21-13-30-70-44-54)73-64(83)53-26-24-49(25-27-53)45-78-34-36-79(37-35-78)59(81)46-89-42-41-88-40-39-87-38-32-71-66(85)62(60(50-15-7-4-8-16-50)51-17-9-5-10-18-51)77-65(84)58-22-14-33-80(58)67(86)61(52-19-11-6-12-20-52)76-63(82)48(2)69-3/h4-5,7-10,13,15-18,21,23-31,43-44,48,52,58,60-62,69H,6,11-12,14,19-20,22,32-42,45-46H2,1-3H3,(H,71,85)(H,73,83)(H,76,82)(H,77,84)(H,72,74,75)/t48-,58-,61-,62-/m0/s1","PBMLWDMSBSZGHC-KOMGJWJNSA-N"
"1022","","BCR-ABL","IAP","","SNIPER(ABL)-15","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCCNC(=O)C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","5000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1094.246","1093.52485948","7.66","79","7","13","6","28","223.47","C58H70F3N9O9","InChI=1S/C58H70F3N9O9/c1-39(62-2)53(71)68-51(42-18-10-5-11-19-42)57(75)70-29-13-22-48(70)55(73)69-52(50(40-14-6-3-7-15-40)41-16-8-4-9-17-41)56(74)64-28-31-77-33-35-78-34-32-76-30-27-63-54(72)44-21-12-20-43(36-44)47-37-49(66-38-65-47)67-45-23-25-46(26-24-45)79-58(59,60)61/h3-4,6-9,12,14-17,20-21,23-26,36-39,42,48,50-52,62H,5,10-11,13,18-19,22,27-35H2,1-2H3,(H,63,72)(H,64,74)(H,68,71)(H,69,73)(H,65,66,67)/t39-,48-,51-,52-/m0/s1","CYNNYMZGPVIXHI-ZUDXTMBRSA-N"
"1023","","BCR-ABL","IAP","","SNIPER(ABL)-47","CCN1CCN(CC2=CC=C(NC(=O)C3=CC=CC(C4=CC=C5N=C(NC(=O)COCCOCCOCCNC(=O)[C@@H](NC(=O)[C@@H]6CCCN6C(=O)[C@@H](NC(=O)[C@H](C)NC)C6CCCCC6)C(C6=CC=CC=C6)C6=CC=CC=C6)SC5=N4)=C3)C=C2C(F)(F)F)CC1","2000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1274.522","1273.59697886","8.04","91","9","15","6","29","237.79","C67H82F3N11O9S","InChI=1S/C67H82F3N11O9S/c1-4-79-31-33-80(34-32-79)42-50-25-26-51(41-52(50)67(68,69)70)73-61(84)49-23-14-22-48(40-49)53-27-28-54-64(74-53)91-66(75-54)76-56(82)43-90-39-38-89-37-36-88-35-29-72-63(86)59(57(45-16-8-5-9-17-45)46-18-10-6-11-19-46)78-62(85)55-24-15-30-81(55)65(87)58(47-20-12-7-13-21-47)77-60(83)44(2)71-3/h5-6,8-11,14,16-19,22-23,25-28,40-41,44,47,55,57-59,71H,4,7,12-13,15,20-21,24,29-39,42-43H2,1-3H3,(H,72,86)(H,73,84)(H,77,83)(H,78,85)(H,75,76,82)/t44-,55-,58-,59-/m0/s1","NGXYXIVUCDETCQ-LXFUJSLCSA-N"
"1024","","BCR-ABL","IAP","","SNIPER(ABL)-19","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCC(=O)N1CCN(C2=CC(NC3=NC=C(C(=O)NC4=C(C)C=CC=C4Cl)S3)=NC(C)=N2)CC1)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","300","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1177.871","1176.53457072","7.23","83","8","16","6","27","250.68","C60H77ClN12O9S","InChI=1S/C60H77ClN12O9S/c1-39-16-14-23-45(61)52(39)68-57(77)47-37-64-60(83-47)67-48-36-49(66-41(3)65-48)71-27-29-72(30-28-71)50(74)38-82-35-34-81-33-32-80-31-25-63-58(78)54(51(42-17-8-5-9-18-42)43-19-10-6-11-20-43)70-56(76)46-24-15-26-73(46)59(79)53(44-21-12-7-13-22-44)69-55(75)40(2)62-4/h5-6,8-11,14,16-20,23,36-37,40,44,46,51,53-54,62H,7,12-13,15,21-22,24-35,38H2,1-4H3,(H,63,78)(H,68,77)(H,69,75)(H,70,76)(H,64,65,66,67)/t40-,46-,53-,54-/m0/s1","SKXVPICURZPVJG-YKQCETGNSA-N"
"1025","","BCR-ABL","IAP","","SNIPER(ABL)-58","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCC(=O)N3CCN(CC4=CC=C(C(=O)NC5=CC=C(C)C(NC6=NC=CC(C7=CC=CN=C7)=N6)=C5)C=C4)CC3)=C2)=CS1)C1CCCCC1","10000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1150.417","1149.54699398","6.55","83","9","17","4","27","231.67","C62H75N11O9S","InChI=1S/C62H75N11O9S/c1-42-16-21-49(37-52(42)69-62-65-24-22-51(68-62)48-13-8-23-64-38-48)66-59(77)46-19-17-44(18-20-46)39-71-26-28-72(29-27-71)55(74)40-81-33-32-79-30-31-80-34-35-82-50-14-7-12-47(36-50)57(75)53-41-83-60(67-53)54-15-9-25-73(54)61(78)56(45-10-5-4-6-11-45)70-58(76)43(2)63-3/h7-8,12-14,16-24,36-38,41,43,45,54,56,63H,4-6,9-11,15,25-35,39-40H2,1-3H3,(H,66,77)(H,70,76)(H,65,68,69)/t43-,54-,56-/m0/s1","TVHMRPZDSBFQBQ-INNJKCEPSA-N"
"1026","","BCR-ABL","IAP","","SNIPER(ABL)-24","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCNC(=O)C3=CC=CC(C4=CC(NC5=CC=C(OC(F)(F)F)C=C5)=NC=N4)=C3)=C2)=CS1)C1CCCCC1","5000","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1031.168","1030.42343119","7.74","73","7","15","4","26","204.46","C52H61F3N8O9S","InChI=1S/C52H61F3N8O9S/c1-34(56-2)48(65)62-46(35-9-4-3-5-10-35)51(67)63-21-8-15-44(63)50-61-43(32-73-50)47(64)37-12-7-14-41(30-37)71-28-27-70-26-25-69-24-23-68-22-20-57-49(66)38-13-6-11-36(29-38)42-31-45(59-33-58-42)60-39-16-18-40(19-17-39)72-52(53,54)55/h6-7,11-14,16-19,29-35,44,46,56H,3-5,8-10,15,20-28H2,1-2H3,(H,57,66)(H,62,65)(H,58,59,60)/t34-,44-,46-/m0/s1","WDQUTOHXUGVTJQ-WUSNILEASA-N"
"1027","","BCR-ABL","IAP","","SNIPER(ABL)-33","CCN1CCN(CC2=CC=C(NC(=O)C3=CC=CC(C4=CC=C5N=C(NC(=O)COCCOCCOCCOC6=CC=CC(C(=O)C7=CSC([C@@H]8CCCN8C(=O)[C@@H](NC(=O)[C@H](C)NC)C8CCCCC8)=N7)=C6)SC5=N4)=C3)C=C2C(F)(F)F)CC1","300","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1211.444","1210.49555058","8.12","85","9","17","4","27","218.78","C61H73F3N10O9S2","InChI=1S/C61H73F3N10O9S2/c1-4-72-23-25-73(26-24-72)36-44-18-19-45(35-47(44)61(62,63)64)66-56(78)43-15-8-13-41(33-43)48-20-21-49-57(67-48)85-60(69-49)70-52(75)37-82-30-29-80-27-28-81-31-32-83-46-16-9-14-42(34-46)54(76)50-38-84-58(68-50)51-17-10-22-74(51)59(79)53(40-11-6-5-7-12-40)71-55(77)39(2)65-3/h8-9,13-16,18-21,33-35,38-40,51,53,65H,4-7,10-12,17,22-32,36-37H2,1-3H3,(H,66,78)(H,71,77)(H,69,70,75)/t39-,51-,53-/m0/s1","NJCPVTOZWPVLBE-XOIMNWENSA-N"
"1028","","BCR-ABL","IAP","","SNIPER(ABL)-39","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCC(=O)N3CCN(C4=CC(NC5=NC=C(C(=O)NC6=C(C)C=CC=C6Cl)S5)=NC(C)=N4)CC3)=C2)=CS1)C1CCCCC1","10","","Degradation of BCR-ABL in K562 cells after 6 h treatment","","","0.54","IC50 of BCR-ABL was tested by TR-FRET","","","","","","","","","","","","","","","10/12/50","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.92/8.06/6.72","Inhibit growth of K562/KCL22/KU812 cells","","","","","","","","","","","","","","","10.1111/cas.13284","1114.793","1113.43314244","7.3","77","8","18","4","25","231.67","C54H68ClN11O9S2","InChI=1S/C54H68ClN11O9S2/c1-34-11-8-16-40(55)47(34)62-51(70)43-31-57-54(77-43)61-44-30-45(59-36(3)58-44)64-19-21-65(22-20-64)46(67)32-74-26-25-72-23-24-73-27-28-75-39-15-9-14-38(29-39)49(68)41-33-76-52(60-41)42-17-10-18-66(42)53(71)48(37-12-6-5-7-13-37)63-50(69)35(2)56-4/h8-9,11,14-16,29-31,33,35,37,42,48,56H,5-7,10,12-13,17-28,32H2,1-4H3,(H,62,70)(H,63,69)(H,57,58,59,61)/t35-,42-,48-/m0/s1","PLCDNLSIFCGNNG-GFKCZKLESA-N"
"1029","","BCR-ABL","cIAP1","","SNIPER(ABL)-56","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCC(=O)N3CCN(C4=CC(NC5=NC=C(C(=O)NC6=C(C)C=CC=C6Cl)S5)=NC(C)=N4)CC3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1026.687","1025.38071294","7.6","71","8","16","4","19","213.21","C50H60ClN11O7S2","InChI=1S/C50H60ClN11O7S2/c1-30-11-8-16-36(51)43(30)58-47(66)39-27-53-50(71-39)57-40-26-41(55-32(3)54-40)60-19-21-61(22-20-60)42(63)28-68-23-24-69-35-15-9-14-34(25-35)45(64)37-29-70-48(56-37)38-17-10-18-62(38)49(67)44(33-12-6-5-7-13-33)59-46(65)31(2)52-4/h8-9,11,14-16,25-27,29,31,33,38,44,52H,5-7,10,12-13,17-24,28H2,1-4H3,(H,58,66)(H,59,65)(H,53,54,55,57)/t31-,38-,44-/m0/s1","BDKSGVHAKMXCIV-WOODEUHSSA-N"
"1030","","BCR-ABL","cIAP1","","SNIPER(ABL)-38","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCC(=O)N3CCN(C4=CC(NC5=NC=C(C(=O)NC6=C(C)C=CC=C6Cl)S5)=NC(C)=N4)CC3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1111/cas.13284","1070.74","1069.40692769","7.45","74","8","17","4","22","222.44","C52H64ClN11O8S2","InChI=1S/C52H64ClN11O8S2/c1-32-11-8-16-38(53)45(32)60-49(68)41-29-55-52(74-41)59-42-28-43(57-34(3)56-42)62-19-21-63(22-20-62)44(65)30-71-24-23-70-25-26-72-37-15-9-14-36(27-37)47(66)39-31-73-50(58-39)40-17-10-18-64(40)51(69)46(35-12-6-5-7-13-35)61-48(67)33(2)54-4/h8-9,11,14-16,27-29,31,33,35,40,46,54H,5-7,10,12-13,17-26,30H2,1-4H3,(H,60,68)(H,61,67)(H,55,56,57,59)/t33-,40-,46-/m0/s1","AEDCCZDEUGMQBZ-DNGMMYLASA-N"
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"1048","P03372","ER","IAP","","SNIPER(ER)-107","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCCOCCCC[C@@H]1CC2=CC(O)=CC=C2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]21)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.M116.768853","1064.419","1063.66094405","8.19","77","8","11","6","28","197.02","C62H89N5O10","InChI=1S/C62H89N5O10/c1-42(63-3)58(70)65-56(45-20-11-6-12-21-45)61(73)67-31-15-23-52(67)59(71)66-57(54(43-16-7-4-8-17-43)44-18-9-5-10-19-44)60(72)64-30-33-75-35-37-77-39-38-76-36-34-74-32-14-13-22-46-40-47-41-48(68)24-25-49(47)50-28-29-62(2)51(55(46)50)26-27-53(62)69/h4-5,7-10,16-19,24-25,41-42,45-46,50-57,63,68-69H,6,11-15,20-23,26-40H2,1-3H3,(H,64,72)(H,65,70)(H,66,71)/t42-,46+,50+,51-,52-,53-,55+,56-,57-,62-/m0/s1","HLFOEFYDVWMRSS-PDRKHGMVSA-N"
"1049","P03372","ER","IAP","","SNIPER(ER)-109","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCC(=O)N(C)CCOC1=CC=C([C@@H]2C3=CC=C(O)C=C3CC[C@@H]2C2=CC=CC=C2)C=C1)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.M116.768853","1107.403","1106.60924282","8.57","81","8","11","5","28","197.1","C65H82N6O10","InChI=1S/C65H82N6O10/c1-45(66-2)62(74)68-60(50-23-14-7-15-24-50)65(77)71-35-16-25-56(71)63(75)69-61(58(47-19-10-5-11-20-47)48-21-12-6-13-22-48)64(76)67-34-37-78-39-40-79-41-42-80-44-57(73)70(3)36-38-81-53-30-26-49(27-31-53)59-54(46-17-8-4-9-18-46)32-28-51-43-52(72)29-33-55(51)59/h4-6,8-13,17-22,26-27,29-31,33,43,45,50,54,56,58-61,66,72H,7,14-16,23-25,28,32,34-42,44H2,1-3H3,(H,67,76)(H,68,74)(H,69,75)/t45-,54+,56-,59-,60-,61-/m0/s1","URDKILVGEVSNPJ-JCMBZIHHSA-N"
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"1051","P03372","ER","XIAP","","SNIPER(ER)-104","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCNC(=O)C2=CC(C3=CN=CC([C@@H]4CCCN4C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)=C3)=CC=C2F)C=C1)C1=CC=CC=C1",">100","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","61","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","",">1000/>1000/>1000","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1055.302","1054.5579562","9.03","77","7","11","4","27","180.89","C61H75FN6O9","InChI=1S/C61H75FN6O9/c1-5-52(43-13-8-6-9-14-43)57(44-18-23-50(69)24-19-44)45-20-25-51(26-21-45)77-32-30-67(4)56(70)41-76-36-35-75-34-33-74-31-28-65-60(72)53-38-47(22-27-54(53)62)48-37-49(40-64-39-48)55-17-12-29-68(55)61(73)58(46-15-10-7-11-16-46)66-59(71)42(2)63-3/h6,8-9,13-14,18-27,37-40,42,46,55,58,63,69H,5,7,10-12,15-17,28-36,41H2,1-4H3,(H,65,72)(H,66,71)/b57-52-/t42-,55-,58-/m0/s1","TYEBWQBTRDRKSI-QLCHOWBWSA-N"
"1052","P03372","ER","XIAP","","SNIPER(ER)-105","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCNC(=O)C2=CC=CC3=C2C=CN3C2=CN=CC([C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)=C2)C=C1)C1=CC=CC=C1","<3/<3","","Degradation of ERalpha in MCF-7 cells after 4/48h treatment","","","69","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","5.3/7.2/55","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1036.284","1035.54697692","8.01","76","7","12","4","27","185.82","C60H73N7O9","InChI=1S/C60H73N7O9/c1-7-50(43-13-9-8-10-14-43)56(44-18-22-48(68)23-19-44)45-20-24-49(25-21-45)76-32-30-65(6)55(69)40-75-36-35-74-34-33-73-31-27-63-59(71)52-15-11-16-54-51(52)26-29-66(54)47-37-46(38-62-39-47)53-17-12-28-67(53)60(72)57(41(2)3)64-58(70)42(4)61-5/h8-11,13-16,18-26,29,37-39,41-42,53,57,61,68H,7,12,17,27-28,30-36,40H2,1-6H3,(H,63,71)(H,64,70)/b56-50-/t42-,53-,57-/m0/s1","CEZKEOAAJBCWLN-GYLRPOFSSA-N"
"1053","P03372","ER","XIAP","","SNIPER(ER)-110","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=CC(O[C@H]3C[C@@H](C(=O)N[C@@H]4CCCC5=CC=CC=C54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)C3)=C2)C=C1)C1=CC=CC=C1","<3/7.7","","Degradation of ERalpha in MCF-7 cells after 4/48h treatment","","","120","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","74/73/330","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1122.414","1121.60890848","10.58","82","8","12","4","29","186.46","C66H83N5O11","InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1","DXLPZZKVYXMXOP-UXACQRMVSA-N"
"1054","P03372","ER","XIAP","","SNIPER(ER)-113","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=C(O[C@H]3C[C@@H](C(=O)N[C@@H]4CCCC5=CC=CC=C54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)C3)C=C2)C=C1)C1=CC=CC=C1","<3/13.3","","Degradation of ERalpha in MCF-7 cells after 4/48h treatment","","","150","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","85/99/810","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1122.414","1121.60890848","10.58","82","8","12","4","29","186.46","C66H83N5O11","InChI=1S/C66H83N5O11/c1-5-57(47-15-8-6-9-16-47)62(49-23-27-52(72)28-24-49)50-25-29-53(30-26-50)80-36-35-70(4)61(73)45-79-40-39-77-37-38-78-41-42-81-54-31-33-55(34-32-54)82-56-43-60(65(75)68-59-22-14-20-48-17-12-13-21-58(48)59)71(44-56)66(76)63(51-18-10-7-11-19-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-17,21,23-34,46,51,56,59-60,63,67,72H,5,7,10-11,14,18-20,22,35-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1","MVGYQGKJHVJHEF-UXACQRMVSA-N"
"1055","P03372","ER","XIAP","","SNIPER(ER)-118","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=CC(CCN3C[C@@H]4CC[C@H]3[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)C4)=C2)C=C1)C1=CC=CC=C1",">100","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","230","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","140/900/>1000","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1016.334","1015.60342917","9.87","74","8","11","4","29","160.16","C60H81N5O9","InChI=1S/C60H81N5O9/c1-5-53(46-14-8-6-9-15-46)57(47-20-24-50(66)25-21-47)48-22-26-51(27-23-48)73-32-31-64(4)56(67)42-72-36-35-70-33-34-71-37-38-74-52-18-12-13-44(39-52)29-30-65-41-45-19-28-55(65)54(40-45)62-60(69)58(49-16-10-7-11-17-49)63-59(68)43(2)61-3/h6,8-9,12-15,18,20-27,39,43,45,49,54-55,58,61,66H,5,7,10-11,16-17,19,28-38,40-42H2,1-4H3,(H,62,69)(H,63,68)/b57-53-/t43-,45+,54-,55-,58-/m0/s1","IMRBKDGQLBEWCO-RYGGPLERSA-N"
"1056","P03372","ER","XIAP","","SNIPER(ER)-119","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=CC=C2O[C@H]2C[C@@H](C(=O)N[C@@H]3CCCC4=CC=CC=C43)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)C2)C=C1)C1=CC=CC=C1","4/15.7","","Degradation of ERalpha in MCF-7 cells after 4/48h treatment","","","200","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","80/48/700","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1122.414","1121.60890848","10.58","82","8","12","4","29","186.46","C66H83N5O11","InChI=1S/C66H83N5O11/c1-5-55(47-17-8-6-9-18-47)62(49-27-31-52(72)32-28-49)50-29-33-53(34-30-50)80-36-35-70(4)61(73)45-79-40-39-77-37-38-78-41-42-81-59-25-14-15-26-60(59)82-54-43-58(65(75)68-57-24-16-22-48-19-12-13-23-56(48)57)71(44-54)66(76)63(51-20-10-7-11-21-51)69-64(74)46(2)67-3/h6,8-9,12-15,17-19,23,25-34,46,51,54,57-58,63,67,72H,5,7,10-11,16,20-22,24,35-45H2,1-4H3,(H,68,75)(H,69,74)/b62-55-/t46-,54-,57+,58-,63-/m0/s1","NTGZVUKHLCPLPK-RDILSQNJSA-N"
"1057","P03372","ER","XIAP","","SNIPER(ER)-121","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=C(CCN3C[C@@H]4CC[C@H]3[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)C4)C=C2)C=C1)C1=CC=CC=C1",">100","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","","","","","","","","","","","","","","","","","650/>1000/>1000","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1016.334","1015.60342917","9.87","74","8","11","4","29","160.16","C60H81N5O9","InChI=1S/C60H81N5O9/c1-5-53(46-12-8-6-9-13-46)57(47-19-23-50(66)24-20-47)48-21-27-52(28-22-48)73-33-32-64(4)56(67)42-72-37-36-70-34-35-71-38-39-74-51-25-16-44(17-26-51)30-31-65-41-45-18-29-55(65)54(40-45)62-60(69)58(49-14-10-7-11-15-49)63-59(68)43(2)61-3/h6,8-9,12-13,16-17,19-28,43,45,49,54-55,58,61,66H,5,7,10-11,14-15,18,29-42H2,1-4H3,(H,62,69)(H,63,68)/b57-53-/t43-,45+,54-,55-,58-/m0/s1","RLQDLUGWXIZLOW-RYGGPLERSA-N"
"1058","P03372","ER","XIAP","","SNIPER(ER)-126","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=CC(C(=O)C3=CN=CC([C@@H]4CCCN4C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)=C3)=C2)C=C1)C1=CC=CC=C1","<3/3.7","","Degradation of ERalpha in MCF-7 cells after 4/48h treatment","","","83","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","68/200/490","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1038.296","1037.5513936","9.34","76","7","12","3","28","178.09","C61H75N5O10","InChI=1S/C61H75N5O10/c1-5-54(44-14-8-6-9-15-44)57(45-21-25-51(67)26-22-45)46-23-27-52(28-24-46)75-31-30-65(4)56(68)42-74-35-34-72-32-33-73-36-37-76-53-19-12-18-48(39-53)59(69)50-38-49(40-63-41-50)55-20-13-29-66(55)61(71)58(47-16-10-7-11-17-47)64-60(70)43(2)62-3/h6,8-9,12,14-15,18-19,21-28,38-41,43,47,55,58,62,67H,5,7,10-11,13,16-17,20,29-37,42H2,1-4H3,(H,64,70)/b57-54-/t43-,55-,58-/m0/s1","QLVUUHMLPDRYAZ-FYNWWMGYSA-N"
"1059","P03372","ER","XIAP","","SNIPER(ER)-130","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOCC(=O)N2CCC([C@H](NC(=O)[C@H](C)NC)C(=O)N3CCC[C@H]3C3=NC4=C(C5=CC=CC=C5)N=CC=C4S3)CC2)C=C1)C1=CC=CC=C1","36.9","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","41","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","68/28/25","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1110.388","1109.5296126","7.94","80","8","14","3","28","194.22","C62H75N7O10S","InChI=1S/C62H75N7O10S/c1-5-51(44-13-8-6-9-14-44)56(45-18-22-49(70)23-19-45)46-20-24-50(25-21-46)79-34-33-67(4)54(71)41-77-39-37-75-35-36-76-38-40-78-42-55(72)68-31-27-48(28-32-68)58(65-60(73)43(2)63-3)62(74)69-30-12-17-52(69)61-66-59-53(80-61)26-29-64-57(59)47-15-10-7-11-16-47/h6-11,13-16,18-26,29,43,48,52,58,63,70H,5,12,17,27-28,30-42H2,1-4H3,(H,65,73)/b56-51-/t43-,52-,58-/m0/s1","BTEFBUSBBSDOGF-DWWKJPFSSA-N"
"1060","P03372","ER","XIAP","","SNIPER(ER)-131","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N2CCC[C@H]2C(=O)NC2=C(C3=CC=CC=C3)N=NS2)C=C1)C1=CC=CC=C1","33.8","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","80","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","25/24/140","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1091.342","1090.51977619","6.92","78","6","15","5","33","232.11","C58H74N8O11S","InChI=1S/C58H74N8O11S/c1-5-48(42-15-8-6-9-16-42)53(43-21-25-46(67)26-22-43)44-23-27-47(28-24-44)77-32-31-65(4)52(69)40-76-38-36-74-34-33-73-35-37-75-39-51(68)60-29-13-12-19-49(61-55(70)41(2)59-3)58(72)66-30-14-20-50(66)56(71)62-57-54(63-64-78-57)45-17-10-7-11-18-45/h6-11,15-18,21-28,41,49-50,59,67H,5,12-14,19-20,29-40H2,1-4H3,(H,60,68)(H,61,70)(H,62,71)/b53-48-/t41-,49-,50-/m0/s1","MADKLDOJBWDGSR-GKQIOZEKSA-N"
"1061","P03372","ER","XIAP","","SNIPER(ER)-134","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=CC(O[C@@H]3C[C@@H](C(=O)N[C@@H]4CCCC5=CC=CC=C54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)C3)=C2)C=C1)C1=CC=CC=C1",">100","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","47","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","550/360/>1000","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1122.414","1121.60890848","10.58","82","8","12","4","29","186.46","C66H83N5O11","InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56+,59+,60-,63-/m0/s1","DXLPZZKVYXMXOP-TWILRSJCSA-N"
"1062","P03372","ER","XIAP","","SNIPER(ER)-136","CC/C(=C(\C1=CC=C(O)C=C1)C1=CC=C(OCCN(C)C(=O)COCCOCCOCCOC2=CC=C(O[C@H]3C[C@@H](C4=NC(C5=CC=C(F)C6=CC=CC=C56)=CS4)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C4CCCCC4)C3)C=C2)C=C1)C1=CC=CC=C1",">100","","Degradation of ERalpha in MCF-7 cells after 4h treatment","","","47","IC50 of ERalpha was tested using the PolarScreen ERalpha Competitor Assay Green","","","","","","","","","","","","","","","890/>1000/>1000","IC50 of cIAP1/cIAP2/XIAP was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1074/jbc.RA117.001091","1176.462","1175.54534292","12.53","85","9","13","3","29","170.25","C68H78FN5O10S","InChI=1S/C68H78FN5O10S/c1-5-56(47-14-8-6-9-15-47)64(48-20-24-51(75)25-21-48)49-22-26-52(27-23-49)82-35-34-73(4)63(76)44-81-39-38-79-36-37-80-40-41-83-53-28-30-54(31-29-53)84-55-42-62(67-71-61(45-85-67)59-32-33-60(69)58-19-13-12-18-57(58)59)74(43-55)68(78)65(50-16-10-7-11-17-50)72-66(77)46(2)70-3/h6,8-9,12-15,18-33,45-46,50,55,62,65,70,75H,5,7,10-11,16-17,34-44H2,1-4H3,(H,72,77)/b64-56-/t46-,55-,62-,65-/m0/s1","RTFPXJSTAFUILP-FIBILLHVSA-N"
"1063","P10275","AR","cIAP1","","SNIPER(AR)-2","CC1=C(C#N)C(C2=CC=C(C#N)C=C2)=C(C)N1CC1=CC=C(C(=O)NCCOCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC2=CC=CC=C2)C=C1","21600","","Degradation of AR in 22Rv1 cells after 6 h treatment","","","27","IC50 of AR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","820.004","819.431947164","3.8","60","4","11","5","24","213.75","C46H57N7O7","InChI=1S/C46H57N7O7/c1-31(2)26-41(52-46(57)43(54)40(49)27-34-8-6-5-7-9-34)45(56)51-19-21-59-23-25-60-24-22-58-20-18-50-44(55)38-16-12-36(13-17-38)30-53-32(3)39(29-48)42(33(53)4)37-14-10-35(28-47)11-15-37/h5-17,31,40-41,43,54H,18-27,30,49H2,1-4H3,(H,50,55)(H,51,56)(H,52,57)/t40-,41+,43+/m1/s1","NHMJRWPSMORJLM-JWZYOJHJSA-N"
"1064","P10275","AR","cIAP1","","SNIPER(AR)-8","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCCOCCNC(=O)C1=CC=C(S(=O)(=O)CC(C)(O)C(=O)NC2=CC=C(C#N)C(C(F)(F)F)=C2)C=C1",">30000","","Degradation of AR in 22Rv1 cells after 6 h treatment","","","1100","IC50 of AR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","921.005","920.36016224","1.89","64","3","13","7","26","268.5","C43H55F3N6O11S","InChI=1S/C43H55F3N6O11S/c1-28(2)23-36(52-40(56)37(53)35(48)24-29-7-5-4-6-8-29)39(55)50-16-18-62-20-22-63-21-19-61-17-15-49-38(54)30-10-13-33(14-11-30)64(59,60)27-42(3,58)41(57)51-32-12-9-31(26-47)34(25-32)43(44,45)46/h4-14,25,28,35-37,53,58H,15-24,27,48H2,1-3H3,(H,49,54)(H,50,55)(H,51,57)(H,52,56)/t35-,36+,37+,42?/m1/s1","PIRRWGXSGGCAEW-OGBWKRBHSA-N"
"1065","P10275","AR","cIAP1","","SNIPER(AR)-23","CC1=NN(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(C)=C1CC1=CC=C(C(=O)NCCOCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC2=CC=CC=C2)C=C1","11700","","Degradation of AR in 22Rv1 cells after 6 h treatment","","","190","IC50 of AR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","863.979","863.419331792","4.9","62","4","11","5","24","202.85","C45H56F3N7O7","InChI=1S/C45H56F3N7O7/c1-29(2)24-40(53-44(59)41(56)39(50)26-32-8-6-5-7-9-32)43(58)52-17-19-61-21-23-62-22-20-60-18-16-51-42(57)34-12-10-33(11-13-34)25-37-30(3)54-55(31(37)4)36-15-14-35(28-49)38(27-36)45(46,47)48/h5-15,27,29,39-41,56H,16-26,50H2,1-4H3,(H,51,57)(H,52,58)(H,53,59)/t39-,40+,41+/m1/s1","ZTVZRLVVINGLIZ-AEKUSUEZSA-N"
"1066","P10275","AR","cIAP1","","SNIPER(AR)-26","CC1=NN(C2=CC=C(C#N)C(Cl)=C2)C(C)=C1CCC1=CC=C(C(=O)NCCOCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC2=CC=CC=C2)C=C1","20500","","Degradation of AR in 22Rv1 cells after 6 h treatment","","","190","IC50 of AR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","844.454","843.408624876","4.94","60","4","11","5","25","202.85","C45H58ClN7O7","InChI=1S/C45H58ClN7O7/c1-30(2)26-41(51-45(57)42(54)40(48)27-34-8-6-5-7-9-34)44(56)50-19-21-59-23-25-60-24-22-58-20-18-49-43(55)35-13-10-33(11-14-35)12-17-38-31(3)52-53(32(38)4)37-16-15-36(29-47)39(46)28-37/h5-11,13-16,28,30,40-42,54H,12,17-27,48H2,1-4H3,(H,49,55)(H,50,56)(H,51,57)/t40-,41+,42+/m1/s1","LMIAQQBKBLWQGJ-IWSHAHEXSA-N"
"1067","P10275","AR","cIAP1","","SNIPER(AR)-27","CC1=NN(C2=CC=C(C#N)C=C2Cl)C(C)=C1CC1=CC=C(C(=O)NCCOCCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC2=CC=CC=C2)C=C1",">30000","","Degradation of AR in 22Rv1 cells after 6 h treatment","","",">10000","IC50 of AR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","830.427","829.392974812","4.64","59","4","11","5","24","202.85","C44H56ClN7O7","InChI=1S/C44H56ClN7O7/c1-29(2)24-39(50-44(56)41(53)38(47)27-32-8-6-5-7-9-32)43(55)49-17-19-58-21-23-59-22-20-57-18-16-48-42(54)35-13-10-33(11-14-35)25-36-30(3)51-52(31(36)4)40-15-12-34(28-46)26-37(40)45/h5-15,26,29,38-39,41,53H,16-25,27,47H2,1-4H3,(H,48,54)(H,49,55)(H,50,56)/t38-,39+,41+/m1/s1","ITBLIPSXEWWMSK-QAOPUTECSA-N"
"1068","P10275","AR","IAP","","SNIPER(AR)-12","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCCOCCOCCOCCNC(=O)C1=CC=C(CN2C(C)=C(C#N)C(C3=CC=C(C#N)C=C3)=C2C)C=C1)C(C1=CC=CC=C1)C1=CC=CC=C1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","1074.337","1073.57386036","6.86","79","7","12","5","27","228.94","C62H75N9O8","InChI=1S/C62H75N9O8/c1-42(65-4)58(72)68-56(50-19-12-7-13-20-50)62(76)70-32-14-21-53(70)60(74)69-57(55(47-15-8-5-9-16-47)48-17-10-6-11-18-48)61(75)67-31-34-78-36-38-79-37-35-77-33-30-66-59(73)51-28-24-46(25-29-51)41-71-43(2)52(40-64)54(44(71)3)49-26-22-45(39-63)23-27-49/h5-6,8-11,15-18,22-29,42,50,53,55-57,65H,7,12-14,19-21,30-38,41H2,1-4H3,(H,66,73)(H,67,75)(H,68,72)(H,69,74)/t42-,53-,56-,57-/m0/s1","DVDLGBJCWMAMRL-IICYZJSVSA-N"
"1069","P10275","AR","cIAP1","","SNIPER(AR)-31","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCNC(=O)C3=CC=C(CN4C(C)=C(C#N)C(C5=CC=C(C#N)C=C5)=C4C)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","967.206","966.446217324","7.08","70","7","13","3","22","200.7","C54H62N8O7S","InChI=1S/C54H62N8O7S/c1-35(57-4)51(64)60-49(41-10-6-5-7-11-41)54(66)61-24-9-14-47(61)53-59-46(34-70-53)50(63)43-12-8-13-44(30-43)69-29-28-68-27-26-67-25-23-58-52(65)42-21-17-39(18-22-42)33-62-36(2)45(32-56)48(37(62)3)40-19-15-38(31-55)16-20-40/h8,12-13,15-22,30,34-35,41,47,49,57H,5-7,9-11,14,23-29,33H2,1-4H3,(H,58,65)(H,60,64)/t35-,47-,49-/m0/s1","XFUPHTLQEMDKEY-IYPQNJMNSA-N"
"1070","P10275","AR","cIAP1","","SNIPER(AR)-60","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCC#CC3=CC=C(CN4C(C)=C(C#N)C(C5=CC=C(C#N)C=C5)=C4C)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","978.229","977.450968356","7.85","71","7","13","2","22","180.83","C56H63N7O7S","InChI=1S/C56H63N7O7S/c1-38(59-4)54(65)61-52(45-12-6-5-7-13-45)56(66)62-25-9-16-50(62)55-60-49(37-71-55)53(64)46-14-8-15-47(33-46)70-32-31-69-30-29-68-28-27-67-26-10-11-41-17-19-43(20-18-41)36-63-39(2)48(35-58)51(40(63)3)44-23-21-42(34-57)22-24-44/h8,14-15,17-24,33,37-38,45,50,52,59H,5-7,9,12-13,16,25-32,36H2,1-4H3,(H,61,65)/t38-,50-,52-/m0/s1","ZVVYDHIAFHJWGP-YJZHHQNSSA-N"
"1071","P10275","AR","cIAP1","","SNIPER(AR)-70","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCCC3=CC=C(CN4C(C)=C(C#N)C(C5=CC=C(C#N)C=C5)=C4C)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","982.261","981.482268484","8.28","71","7","13","2","25","180.83","C56H67N7O7S","InChI=1S/C56H67N7O7S/c1-38(59-4)54(65)61-52(45-12-6-5-7-13-45)56(66)62-25-9-16-50(62)55-60-49(37-71-55)53(64)46-14-8-15-47(33-46)70-32-31-69-30-29-68-28-27-67-26-10-11-41-17-19-43(20-18-41)36-63-39(2)48(35-58)51(40(63)3)44-23-21-42(34-57)22-24-44/h8,14-15,17-24,33,37-38,45,50,52,59H,5-7,9-13,16,25-32,36H2,1-4H3,(H,61,65)/t38-,50-,52-/m0/s1","AOUDBQAAATYINN-YJZHHQNSSA-N"
"1072","P10275","AR","cIAP1","","SNIPER(AR)-51","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCOC3=CC=C(CN4C(C)=C(C#N)C(C5=CC=C(C#N)C=C5)=C4C)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","984.233","983.46153304","7.63","71","7","14","2","25","190.06","C55H65N7O8S","InChI=1S/C55H65N7O8S/c1-37(58-4)53(64)60-51(43-10-6-5-7-11-43)55(65)61-23-9-14-49(61)54-59-48(36-71-54)52(63)44-12-8-13-46(32-44)70-31-29-68-27-25-66-24-26-67-28-30-69-45-21-17-41(18-22-45)35-62-38(2)47(34-57)50(39(62)3)42-19-15-40(33-56)16-20-42/h8,12-13,15-22,32,36-37,43,49,51,58H,5-7,9-11,14,23-31,35H2,1-4H3,(H,60,64)/t37-,49-,51-/m0/s1","YKLNRBANSQLMHA-JWWZLTTOSA-N"
"1073","P10275","AR","cIAP1","","SNIPER(AR)-53","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCOC3=CC=CC(CN4C(C)=C(C#N)C(C5=CC=C(C#N)C=C5)=C4C)=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.7b00168","984.233","983.46153304","7.63","71","7","14","2","25","190.06","C55H65N7O8S","InChI=1S/C55H65N7O8S/c1-37(58-4)53(64)60-51(43-12-6-5-7-13-43)55(65)61-22-10-17-49(61)54-59-48(36-71-54)52(63)44-14-9-16-46(32-44)70-30-28-68-26-24-66-23-25-67-27-29-69-45-15-8-11-41(31-45)35-62-38(2)47(34-57)50(39(62)3)42-20-18-40(33-56)19-21-42/h8-9,11,14-16,18-21,31-32,36-37,43,49,51,58H,5-7,10,12-13,17,22-30,35H2,1-4H3,(H,60,64)/t37-,49-,51-/m0/s1","XCECZUPNPUFBAS-JWWZLTTOSA-N"
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"1086","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCCCCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","881.959","881.30183884","5.43","63","7","10","5","19","216.6","C45H45F2N7O8S","InChI=1S/C45H45F2N7O8S/c1-2-20-63(61,62)53-35-16-15-34(46)39(40(35)47)41(57)33-25-51-42-31(33)21-28(24-50-42)27-11-9-26(10-12-27)23-49-37(55)8-6-4-3-5-7-19-48-29-13-14-30-32(22-29)45(60)54(44(30)59)36-17-18-38(56)52-43(36)58/h9-16,21-22,24-25,36,48,53H,2-8,17-20,23H2,1H3,(H,49,55)(H,50,51)(H,52,56,58)","QSLVROVXRVADOW-UHFFFAOYSA-N"
"1087","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","899.93","899.276018016","2.98","64","7","12","5","20","235.06","C44H43F2N7O10S","InChI=1S/C44H43F2N7O10S/c1-2-19-64(60,61)52-34-10-9-33(45)38(39(34)46)40(56)32-24-50-41-30(32)20-27(23-49-41)26-5-3-25(4-6-26)22-48-36(54)13-15-62-17-18-63-16-14-47-28-7-8-29-31(21-28)44(59)53(43(29)58)35-11-12-37(55)51-42(35)57/h3-10,20-21,23-24,35,47,52H,2,11-19,22H2,1H3,(H,48,54)(H,49,50)(H,51,55,57)","BVTQWELPMBVYEW-UHFFFAOYSA-N"
"1088","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCOCCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","943.983","943.302232764","2.83","67","7","13","5","23","244.29","C46H47F2N7O11S","InChI=1S/C46H47F2N7O11S/c1-2-21-67(62,63)54-36-10-9-35(47)40(41(36)48)42(58)34-26-52-43-32(34)22-29(25-51-43)28-5-3-27(4-6-28)24-50-38(56)13-15-64-17-19-66-20-18-65-16-14-49-30-7-8-31-33(23-30)46(61)55(45(31)60)37-11-12-39(57)53-44(37)59/h3-10,22-23,25-26,37,49,54H,2,11-21,24H2,1H3,(H,50,56)(H,51,52)(H,53,57,59)","TXWYDKZMTKIQPV-UHFFFAOYSA-N"
"1089","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCOCCOCCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","988.036","987.328447512","2.68","70","7","14","5","26","253.52","C48H51F2N7O12S","InChI=1S/C48H51F2N7O12S/c1-2-23-70(64,65)56-38-10-9-37(49)42(43(38)50)44(60)36-28-54-45-34(36)24-31(27-53-45)30-5-3-29(4-6-30)26-52-40(58)13-15-66-17-19-68-21-22-69-20-18-67-16-14-51-32-7-8-33-35(25-32)48(63)57(47(33)62)39-11-12-41(59)55-46(39)61/h3-10,24-25,27-28,39,51,56H,2,11-23,26H2,1H3,(H,52,58)(H,53,54)(H,55,59,61)","DZIOSQHBUIKFOE-UHFFFAOYSA-N"
"1090","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCOCCOCCOCCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1032.089","1031.35466226","2.53","73","7","15","5","29","262.75","C50H55F2N7O13S","InChI=1S/C50H55F2N7O13S/c1-2-25-73(66,67)58-40-10-9-39(51)44(45(40)52)46(62)38-30-56-47-36(38)26-33(29-55-47)32-5-3-31(4-6-32)28-54-42(60)13-15-68-17-19-70-21-23-72-24-22-71-20-18-69-16-14-53-34-7-8-35-37(27-34)50(65)59(49(35)64)41-11-12-43(61)57-48(41)63/h3-10,26-27,29-30,41,53,58H,2,11-25,28H2,1H3,(H,54,60)(H,55,56)(H,57,61,63)","KATJPMPDUGNPFB-UHFFFAOYSA-N"
"1091","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","882.951","882.308321188","3.88","63","8","13","3","14","208.9","C43H44F2N10O7S","InChI=1S/C43H44F2N10O7S/c1-3-20-63(61,62)51-31-10-9-29(44)40(38(31)45)54-23-28(25-21-46-24-47-22-25)39-32(54)11-13-34(49-39)52(2)26-15-18-53(19-16-26)36(57)8-5-17-48-30-7-4-6-27-37(30)43(60)55(42(27)59)33-12-14-35(56)50-41(33)58/h4,6-7,9-11,13,21-24,26,33,48,51H,3,5,8,12,14-20H2,1-2H3,(H,50,56,58)","PUSGXHSTSNJVEW-UHFFFAOYSA-N"
"1092","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","896.978","896.323971252","4.23","64","8","13","3","15","208.9","C44H46F2N10O7S","InChI=1S/C44H46F2N10O7S/c1-3-21-64(62,63)52-32-11-10-30(45)41(39(32)46)55-24-29(26-22-47-25-48-23-26)40-33(55)12-14-35(50-40)53(2)27-16-19-54(20-17-27)37(58)9-4-5-18-49-31-8-6-7-28-38(31)44(61)56(43(28)60)34-13-15-36(57)51-42(34)59/h6-8,10-12,14,22-25,27,34,49,52H,3-5,9,13,15-21H2,1-2H3,(H,51,57,59)","XPSXOXYUSSPDGB-UHFFFAOYSA-N"
"1093","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","911.005","910.339621316","4.59","65","8","13","3","16","208.9","C45H48F2N10O7S","InChI=1S/C45H48F2N10O7S/c1-3-22-65(63,64)53-33-12-11-31(46)42(40(33)47)56-25-30(27-23-48-26-49-24-27)41-34(56)13-15-36(51-41)54(2)28-17-20-55(21-18-28)38(59)10-5-4-6-19-50-32-9-7-8-29-39(32)45(62)57(44(29)61)35-14-16-37(58)52-43(35)60/h7-9,11-13,15,23-26,28,35,50,53H,3-6,10,14,16-22H2,1-2H3,(H,52,58,60)","ZYADZBTUBZNGHA-UHFFFAOYSA-N"
"1094","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","912.977","912.318885872","3.37","65","8","14","3","16","218.13","C44H46F2N10O8S","InChI=1S/C44H46F2N10O8S/c1-3-21-65(62,63)52-32-8-7-30(45)41(39(32)46)55-24-29(26-22-47-25-48-23-26)40-33(55)9-11-35(50-40)53(2)27-13-17-54(18-14-27)37(58)15-19-64-20-16-49-31-6-4-5-28-38(31)44(61)56(43(28)60)34-10-12-36(57)51-42(34)59/h4-9,11,22-25,27,34,49,52H,3,10,12-21H2,1-2H3,(H,51,57,59)","WBMFMROKRSRXGQ-UHFFFAOYSA-N"
"1095","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","925.032","924.35527138","5.13","66","8","13","3","17","208.9","C46H50F2N10O7S","InChI=1S/C46H50F2N10O7S/c1-3-23-66(64,65)54-34-13-12-32(47)43(41(34)48)57-26-31(28-24-49-27-50-25-28)42-35(57)14-16-37(52-42)55(2)29-18-21-56(22-19-29)39(60)11-6-4-5-7-20-51-33-10-8-9-30-40(33)46(63)58(45(30)62)36-15-17-38(59)53-44(36)61/h8-10,12-14,16,24-27,29,36,51,54H,3-7,11,15,17-23H2,1-2H3,(H,53,59,61)","UJAMNYUHLCPTPD-UHFFFAOYSA-N"
"1096","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","939.059","938.370921444","5.68","67","8","13","3","18","208.9","C47H52F2N10O7S","InChI=1S/C47H52F2N10O7S/c1-3-24-67(65,66)55-35-14-13-33(48)44(42(35)49)58-27-32(29-25-50-28-51-26-29)43-36(58)15-17-38(53-43)56(2)30-19-22-57(23-20-30)40(61)12-7-5-4-6-8-21-52-34-11-9-10-31-41(34)47(64)59(46(31)63)37-16-18-39(60)54-45(37)62/h9-11,13-15,17,25-28,30,37,52,55H,3-8,12,16,18-24H2,1-2H3,(H,54,60,62)","PKGSOQUZBQNEQH-UHFFFAOYSA-N"
"1097","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","957.03","956.34510062","3.23","68","8","15","3","19","227.36","C46H50F2N10O9S","InChI=1S/C46H50F2N10O9S/c1-3-23-68(64,65)54-34-8-7-32(47)43(41(34)48)57-26-31(28-24-49-27-50-25-28)42-35(57)9-11-37(52-42)55(2)29-13-17-56(18-14-29)39(60)15-19-66-21-22-67-20-16-51-33-6-4-5-30-40(33)46(63)58(45(30)62)36-10-12-38(59)53-44(36)61/h4-9,11,24-27,29,36,51,54H,3,10,12-23H2,1-2H3,(H,53,59,61)","ZLPZHJPPTVEEAC-UHFFFAOYSA-N"
"1098","P15056","BRAF V600E","CRBN","","P4B","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","15","82","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","12","Inhibition of BRAF V600E","","","5.6","SPR","","","","","","","1.4","0.77","","","900","FP","","","","","","","","","","","","","","","2570","FP","","","","","","","","","","","","","","","71/75/147","Inhibit proliferation of A375/WM266-4/RKO cells","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1045.136","1044.39753012","2.93","74","8","17","3","25","245.82","C50H58F2N10O11S","InChI=1S/C50H58F2N10O11S/c1-3-27-74(68,69)58-38-8-7-36(51)47(45(38)52)61-30-35(32-28-53-31-54-29-32)46-39(61)9-11-41(56-46)59(2)33-13-17-60(18-14-33)43(64)15-19-70-21-23-72-25-26-73-24-22-71-20-16-55-37-6-4-5-34-44(37)50(67)62(49(34)66)40-10-12-42(63)57-48(40)65/h4-9,11,28-31,33,40,55,58H,3,10,12-27H2,1-2H3,(H,57,63,65)","GJCIYFAPQUEGNE-UHFFFAOYSA-N"
"1098","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1045.136","1044.39753012","2.93","74","8","17","3","25","245.82","C50H58F2N10O11S","InChI=1S/C50H58F2N10O11S/c1-3-27-74(68,69)58-38-8-7-36(51)47(45(38)52)61-30-35(32-28-53-31-54-29-32)46-39(61)9-11-41(56-46)59(2)33-13-17-60(18-14-33)43(64)15-19-70-21-23-72-25-26-73-24-22-71-20-16-55-37-6-4-5-34-44(37)50(67)62(49(34)66)40-10-12-42(63)57-48(40)65/h4-9,11,28-31,33,40,55,58H,3,10,12-27H2,1-2H3,(H,57,63,65)","GJCIYFAPQUEGNE-UHFFFAOYSA-N"
"1099","P15056","BRAF V600E","CRBN","","P5B","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","70","82","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","25","Inhibition of BRAF V600E","","","","","","","","","","","","","","","850","FP","","","","","","","","","","","","","","","2170","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1089.189","1088.42374486","2.78","77","8","18","3","28","255.05","C52H62F2N10O12S","InChI=1S/C52H62F2N10O12S/c1-3-29-77(70,71)60-40-8-7-38(53)49(47(40)54)63-32-37(34-30-55-33-56-31-34)48-41(63)9-11-43(58-48)61(2)35-13-17-62(18-14-35)45(66)15-19-72-21-23-74-25-27-76-28-26-75-24-22-73-20-16-57-39-6-4-5-36-46(39)52(69)64(51(36)68)42-10-12-44(65)59-50(42)67/h4-9,11,30-33,35,42,57,60H,3,10,12-29H2,1-2H3,(H,59,65,67)","RQROXFBXOKHLAH-UHFFFAOYSA-N"
"1099","P15056","BRAF V600E","CRBN","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1089.189","1088.42374486","2.78","77","8","18","3","28","255.05","C52H62F2N10O12S","InChI=1S/C52H62F2N10O12S/c1-3-29-77(70,71)60-40-8-7-38(53)49(47(40)54)63-32-37(34-30-55-33-56-31-34)48-41(63)9-11-43(58-48)61(2)35-13-17-62(18-14-35)45(66)15-19-72-21-23-74-25-27-76-28-26-75-24-22-73-20-16-57-39-6-4-5-36-46(39)52(69)64(51(36)68)42-10-12-44(65)59-50(42)67/h4-9,11,30-33,35,42,57,60H,3,10,12-29H2,1-2H3,(H,59,65,67)","RQROXFBXOKHLAH-UHFFFAOYSA-N"
"1100","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1011.187","1010.36305919","5.76","71","7","11","6","19","232.65","C51H56F2N8O8S2","InChI=1S/C51H56F2N8O8S2/c1-6-20-71(68,69)60-39-19-18-38(52)43(44(39)53)45(65)37-26-56-48-36(37)21-34(25-55-48)32-14-10-30(11-15-32)23-54-41(63)8-7-9-42(64)59-47(51(3,4)5)50(67)61-27-35(62)22-40(61)49(66)57-24-31-12-16-33(17-13-31)46-29(2)58-28-70-46/h10-19,21,25-26,28,35,40,47,60,62H,6-9,20,22-24,27H2,1-5H3,(H,54,63)(H,55,56)(H,57,66)(H,59,64)/t35-,40+,47-/m1/s1","ZJCPOMYYYDTFJF-SCJDURHCSA-N"
"1101","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1025.214","1024.37870926","6.12","72","7","11","6","20","232.65","C52H58F2N8O8S2","InChI=1S/C52H58F2N8O8S2/c1-6-21-72(69,70)61-40-20-19-39(53)44(45(40)54)46(66)38-27-57-49-37(38)22-35(26-56-49)33-15-11-31(12-16-33)24-55-42(64)9-7-8-10-43(65)60-48(52(3,4)5)51(68)62-28-36(63)23-41(62)50(67)58-25-32-13-17-34(18-14-32)47-30(2)59-29-71-47/h11-20,22,26-27,29,36,41,48,61,63H,6-10,21,23-25,28H2,1-5H3,(H,55,64)(H,56,57)(H,58,67)(H,60,65)/t36-,41+,48-/m1/s1","JSZKONKRSZPUMG-CDFOKZDLSA-N"
"1102","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(CNC(=O)CCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1041.213","1040.37362388","5.26","73","7","12","6","21","241.88","C52H58F2N8O9S2","InChI=1S/C52H58F2N8O9S2/c1-6-21-73(69,70)61-40-16-15-39(53)44(45(40)54)46(66)38-27-57-49-37(38)22-35(26-56-49)33-11-7-31(8-12-33)24-55-42(64)17-19-71-20-18-43(65)60-48(52(3,4)5)51(68)62-28-36(63)23-41(62)50(67)58-25-32-9-13-34(14-10-32)47-30(2)59-29-72-47/h7-16,22,26-27,29,36,41,48,61,63H,6,17-21,23-25,28H2,1-5H3,(H,55,64)(H,56,57)(H,58,67)(H,60,65)/t36-,41+,48-/m1/s1","CEAYLPBMOKYPIH-CDFOKZDLSA-N"
"1103","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1098.313","1097.44270648","4.96","77","8","15","4","20","234.18","C54H65F2N11O8S2","InChI=1S/C54H65F2N11O8S2/c1-7-24-77(73,74)63-41-13-12-40(55)49(47(41)56)66-30-39(36-27-57-31-58-28-36)48-42(66)14-15-44(61-48)64(6)37-16-20-65(21-17-37)46(70)19-23-75-22-18-45(69)62-51(54(3,4)5)53(72)67-29-38(68)25-43(67)52(71)59-26-34-8-10-35(11-9-34)50-33(2)60-32-76-50/h8-15,27-28,30-32,37-38,43,51,63,68H,7,16-26,29H2,1-6H3,(H,59,71)(H,62,69)/t38-,43+,51-/m1/s1","PTQLGKHVXQXJQX-MJGODALBSA-N"
"1104","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1142.366","1141.46892123","4.81","80","8","16","4","23","243.41","C56H69F2N11O9S2","InChI=1S/C56H69F2N11O9S2/c1-7-26-80(75,76)65-43-13-12-42(57)51(49(43)58)68-32-41(38-29-59-33-60-30-38)50-44(68)14-15-46(63-50)66(6)39-16-20-67(21-17-39)48(72)19-23-78-25-24-77-22-18-47(71)64-53(56(3,4)5)55(74)69-31-40(70)27-45(69)54(73)61-28-36-8-10-37(11-9-36)52-35(2)62-34-79-52/h8-15,29-30,32-34,39-40,45,53,65,70H,7,16-28,31H2,1-6H3,(H,61,73)(H,64,71)/t40-,45+,53-/m1/s1","SKILXDOLZNZZFN-USLBEQMTSA-N"
"1105","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1186.419","1185.49513598","4.66","83","8","17","4","26","252.64","C58H73F2N11O10S2","InChI=1S/C58H73F2N11O10S2/c1-7-28-83(77,78)67-45-13-12-44(59)53(51(45)60)70-34-43(40-31-61-35-62-32-40)52-46(70)14-15-48(65-52)68(6)41-16-20-69(21-17-41)50(74)19-23-80-25-27-81-26-24-79-22-18-49(73)66-55(58(3,4)5)57(76)71-33-42(72)29-47(71)56(75)63-30-38-8-10-39(11-9-38)54-37(2)64-36-82-54/h8-15,31-32,34-36,41-42,47,55,67,72H,7,16-30,33H2,1-6H3,(H,63,75)(H,66,73)/t42-,47+,55-/m1/s1","UEECWMDSNPZABC-MDXUJHOYSA-N"
"1106","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1230.472","1229.52135072","4.51","86","8","18","4","29","261.87","C60H77F2N11O11S2","InChI=1S/C60H77F2N11O11S2/c1-7-30-86(79,80)69-47-13-12-46(61)55(53(47)62)72-36-45(42-33-63-37-64-34-42)54-48(72)14-15-50(67-54)70(6)43-16-20-71(21-17-43)52(76)19-23-82-25-27-84-29-28-83-26-24-81-22-18-51(75)68-57(60(3,4)5)59(78)73-35-44(74)31-49(73)58(77)65-32-40-8-10-41(11-9-40)56-39(2)66-38-85-56/h8-15,33-34,36-38,43-44,49,57,69,74H,7,16-32,35H2,1-6H3,(H,65,77)(H,68,75)/t44-,49+,57-/m1/s1","FFRMYNSJXNXLED-ZPPJDHJYSA-N"
"1106","P15056","BRAF V600E","VHL","","VH-PEG4-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","100","40","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","67","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1230.472","1229.52135072","4.51","86","8","18","4","29","261.87","C60H77F2N11O11S2","InChI=1S/C60H77F2N11O11S2/c1-7-30-86(79,80)69-47-13-12-46(61)55(53(47)62)72-36-45(42-33-63-37-64-34-42)54-48(72)14-15-50(67-54)70(6)43-16-20-71(21-17-43)52(76)19-23-82-25-27-84-29-28-83-26-24-81-22-18-51(75)68-57(60(3,4)5)59(78)73-35-44(74)31-49(73)58(77)65-32-40-8-10-41(11-9-40)56-39(2)66-38-85-56/h8-15,33-34,36-38,43-44,49,57,69,74H,7,16-32,35H2,1-6H3,(H,65,77)(H,68,75)/t44-,49+,57-/m1/s1","FFRMYNSJXNXLED-ZPPJDHJYSA-N"
"1107","P15056","BRAF V600E","VHL","","","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)=CC=C32)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02083","1274.525","1273.54756547","4.37","89","8","19","4","32","271.1","C62H81F2N11O12S2","InChI=1S/C62H81F2N11O12S2/c1-7-32-89(81,82)71-49-13-12-48(63)57(55(49)64)74-38-47(44-35-65-39-66-36-44)56-50(74)14-15-52(69-56)72(6)45-16-20-73(21-17-45)54(78)19-23-84-25-27-86-29-31-87-30-28-85-26-24-83-22-18-53(77)70-59(62(3,4)5)61(80)75-37-46(76)33-51(75)60(79)67-34-42-8-10-43(11-9-42)58-41(2)68-40-88-58/h8-15,35-36,38-40,45-46,51,59,71,76H,7,16-34,37H2,1-6H3,(H,67,79)(H,70,77)/t46-,51+,59-/m1/s1","CWEJDBKQPPYBJZ-KYLXKTIOSA-N"
"1108","P04035","HMGCR","CRBN","","P13A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1027.12","1026.42873293","5.27","75","8","15","6","25","256.54","C55H59FN8O11","InChI=1S/C55H59FN8O11/c1-33(2)50-49(53(71)58-37-10-4-3-5-11-37)47(51(34-16-18-36(56)19-17-34)63(50)24-22-39(65)30-40(66)31-46(68)69)35-9-6-13-41(29-35)75-26-8-12-38-32-62(61-60-38)25-28-74-27-23-57-43-15-7-14-42-48(43)55(73)64(54(42)72)44-20-21-45(67)59-52(44)70/h3-7,9-11,13-19,29,32-33,39-40,44,57,65-66H,8,12,20-28,30-31H2,1-2H3,(H,58,71)(H,68,69)(H,59,67,70)/t39-,40-,44?/m1/s1","KOPPBUIQHDCVSF-FPWGYEBVSA-N"
"1109","P04035","HMGCR","CRBN","","P14A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1041.147","1040.44438299","5.62","76","8","15","6","26","256.54","C56H61FN8O11","InChI=1S/C56H61FN8O11/c1-34(2)51-50(54(72)59-38-11-4-3-5-12-38)48(52(35-17-19-37(57)20-18-35)64(51)25-23-40(66)31-41(67)32-47(69)70)36-10-8-14-42(30-36)76-27-7-6-13-39-33-63(62-61-39)26-29-75-28-24-58-44-16-9-15-43-49(44)56(74)65(55(43)73)45-21-22-46(68)60-53(45)71/h3-5,8-12,14-20,30,33-34,40-41,45,58,66-67H,6-7,13,21-29,31-32H2,1-2H3,(H,59,72)(H,69,70)(H,60,68,71)/t40-,41-,45?/m1/s1","LYZQONNTSQMVGJ-WGFAKLPBSA-N"
"1110","P04035","HMGCR","CRBN","","P15A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1055.174","1054.46003306","5.98","77","8","15","6","27","256.54","C57H63FN8O11","InChI=1S/C57H63FN8O11/c1-35(2)52-51(55(73)60-39-12-5-3-6-13-39)49(53(36-18-20-38(58)21-19-36)65(52)26-24-41(67)32-42(68)33-48(70)71)37-11-9-15-43(31-37)77-28-8-4-7-14-40-34-64(63-62-40)27-30-76-29-25-59-45-17-10-16-44-50(45)57(75)66(56(44)74)46-22-23-47(69)61-54(46)72/h3,5-6,9-13,15-21,31,34-35,41-42,46,59,67-68H,4,7-8,14,22-30,32-33H2,1-2H3,(H,60,73)(H,70,71)(H,61,69,72)/t41-,42-,46?/m1/s1","JMLYHOMYNWELEV-RFIMGWBHSA-N"
"1111","P04035","HMGCR","CRBN","","P16A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1071.173","1070.45494768","5.12","78","8","16","6","28","265.77","C57H63FN8O12","InChI=1S/C57H63FN8O12/c1-35(2)52-51(55(73)60-39-10-4-3-5-11-39)49(53(36-16-18-38(58)19-17-36)65(52)24-22-41(67)32-42(68)33-48(70)71)37-9-6-13-43(31-37)78-26-8-12-40-34-64(63-62-40)25-28-77-30-29-76-27-23-59-45-15-7-14-44-50(45)57(75)66(56(44)74)46-20-21-47(69)61-54(46)72/h3-7,9-11,13-19,31,34-35,41-42,46,59,67-68H,8,12,20-30,32-33H2,1-2H3,(H,60,73)(H,70,71)(H,61,69,72)/t41-,42-,46?/m1/s1","PAYQRGVUYUNIDJ-RFIMGWBHSA-N"
"1112","P04035","HMGCR","CRBN","","P17A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1085.2","1084.47059774","5.48","79","8","16","6","29","265.77","C58H65FN8O12","InChI=1S/C58H65FN8O12/c1-36(2)53-52(56(74)61-40-11-4-3-5-12-40)50(54(37-17-19-39(59)20-18-37)66(53)25-23-42(68)33-43(69)34-49(71)72)38-10-8-14-44(32-38)79-27-7-6-13-41-35-65(64-63-41)26-29-78-31-30-77-28-24-60-46-16-9-15-45-51(46)58(76)67(57(45)75)47-21-22-48(70)62-55(47)73/h3-5,8-12,14-20,32,35-36,42-43,47,60,68-69H,6-7,13,21-31,33-34H2,1-2H3,(H,61,74)(H,71,72)(H,62,70,73)/t42-,43-,47?/m1/s1","LFNFPNZCEJIEOS-VDKNZPKNSA-N"
"1113","P04035","HMGCR","CRBN","","P18A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1099.227","1098.4862478","5.83","80","8","16","6","30","265.77","C59H67FN8O12","InChI=1S/C59H67FN8O12/c1-37(2)54-53(57(75)62-41-12-5-3-6-13-41)51(55(38-18-20-40(60)21-19-38)67(54)26-24-43(69)34-44(70)35-50(72)73)39-11-9-15-45(33-39)80-28-8-4-7-14-42-36-66(65-64-42)27-30-79-32-31-78-29-25-61-47-17-10-16-46-52(47)59(77)68(58(46)76)48-22-23-49(71)63-56(48)74/h3,5-6,9-13,15-21,33,36-37,43-44,48,61,69-70H,4,7-8,14,22-32,34-35H2,1-2H3,(H,62,75)(H,72,73)(H,63,71,74)/t43-,44-,48?/m1/s1","BCTTUKOMPZRYHS-OGVMARDASA-N"
"1114","P04035","HMGCR","CRBN","","P19A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1115.226","1114.48116242","4.97","81","8","17","6","31","275.0","C59H67FN8O13","InChI=1S/C59H67FN8O13/c1-37(2)54-53(57(75)62-41-10-4-3-5-11-41)51(55(38-16-18-40(60)19-17-38)67(54)24-22-43(69)34-44(70)35-50(72)73)39-9-6-13-45(33-39)81-26-8-12-42-36-66(65-64-42)25-28-79-30-32-80-31-29-78-27-23-61-47-15-7-14-46-52(47)59(77)68(58(46)76)48-20-21-49(71)63-56(48)74/h3-7,9-11,13-19,33,36-37,43-44,48,61,69-70H,8,12,20-32,34-35H2,1-2H3,(H,62,75)(H,72,73)(H,63,71,74)/t43-,44-,48?/m1/s1","YHXVDJNFXLNLSO-OGVMARDASA-N"
"1115","P04035","HMGCR","CRBN","","P20A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1129.253","1128.49681249","5.33","82","8","17","6","32","275.0","C60H69FN8O13","InChI=1S/C60H69FN8O13/c1-38(2)55-54(58(76)63-42-11-4-3-5-12-42)52(56(39-17-19-41(61)20-18-39)68(55)25-23-44(70)35-45(71)36-51(73)74)40-10-8-14-46(34-40)82-27-7-6-13-43-37-67(66-65-43)26-29-80-31-33-81-32-30-79-28-24-62-48-16-9-15-47-53(48)60(78)69(59(47)77)49-21-22-50(72)64-57(49)75/h3-5,8-12,14-20,34,37-38,44-45,49,62,70-71H,6-7,13,21-33,35-36H2,1-2H3,(H,63,76)(H,73,74)(H,64,72,75)/t44-,45-,49?/m1/s1","UHFHFZUJWIFRPV-OEUTXLNUSA-N"
"1116","P04035","HMGCR","CRBN","","P21A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","1800","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1143.28","1142.51246255","5.68","83","8","17","6","33","275.0","C61H71FN8O13","InChI=1S/C61H71FN8O13/c1-39(2)56-55(59(77)64-43-12-5-3-6-13-43)53(57(40-18-20-42(62)21-19-40)69(56)26-24-45(71)36-46(72)37-52(74)75)41-11-9-15-47(35-41)83-28-8-4-7-14-44-38-68(67-66-44)27-30-81-32-34-82-33-31-80-29-25-63-49-17-10-16-48-54(49)61(79)70(60(48)78)50-22-23-51(73)65-58(50)76/h3,5-6,9-13,15-21,35,38-39,45-46,50,63,71-72H,4,7-8,14,22-34,36-37H2,1-2H3,(H,64,77)(H,74,75)(H,65,73,76)/t45-,46-,50?/m1/s1","VQPHUFKUCJQDDO-SRQCOUMPSA-N"
"1117","P04035","HMGCR","CRBN","","P22A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","100","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1159.279","1158.50737717","4.82","84","8","18","6","34","284.23","C61H71FN8O14","InChI=1S/C61H71FN8O14/c1-39(2)56-55(59(77)64-43-10-4-3-5-11-43)53(57(40-16-18-42(62)19-17-40)69(56)24-22-45(71)36-46(72)37-52(74)75)41-9-6-13-47(35-41)84-26-8-12-44-38-68(67-66-44)25-28-81-30-32-83-34-33-82-31-29-80-27-23-63-49-15-7-14-48-54(49)61(79)70(60(48)78)50-20-21-51(73)65-58(50)76/h3-7,9-11,13-19,35,38-39,45-46,50,63,71-72H,8,12,20-34,36-37H2,1-2H3,(H,64,77)(H,74,75)(H,65,73,76)/t45-,46-,50?/m1/s1","JGEJZAWLMMDNEZ-SRQCOUMPSA-N"
"1118","P04035","HMGCR","CRBN","","P23A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","400","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1173.306","1172.52302724","5.18","85","8","18","6","35","284.23","C62H73FN8O14","InChI=1S/C62H73FN8O14/c1-40(2)57-56(60(78)65-44-11-4-3-5-12-44)54(58(41-17-19-43(63)20-18-41)70(57)25-23-46(72)37-47(73)38-53(75)76)42-10-8-14-48(36-42)85-27-7-6-13-45-39-69(68-67-45)26-29-82-31-33-84-35-34-83-32-30-81-28-24-64-50-16-9-15-49-55(50)62(80)71(61(49)79)51-21-22-52(74)66-59(51)77/h3-5,8-12,14-20,36,39-40,46-47,51,64,72-73H,6-7,13,21-35,37-38H2,1-2H3,(H,65,78)(H,75,76)(H,66,74,77)/t46-,47-,51?/m1/s1","FGHBFYYPECSTEQ-CFQHIMGQSA-N"
"1119","P04035","HMGCR","CRBN","","P24A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","500","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1187.333","1186.5386773","5.54","86","8","18","6","36","284.23","C63H75FN8O14","InChI=1S/C63H75FN8O14/c1-41(2)58-57(61(79)66-45-12-5-3-6-13-45)55(59(42-18-20-44(64)21-19-42)71(58)26-24-47(73)38-48(74)39-54(76)77)43-11-9-15-49(37-43)86-28-8-4-7-14-46-40-70(69-68-46)27-30-83-32-34-85-36-35-84-33-31-82-29-25-65-51-17-10-16-50-56(51)63(81)72(62(50)80)52-22-23-53(75)67-60(52)78/h3,5-6,9-13,15-21,37,40-41,47-48,52,65,73-74H,4,7-8,14,22-36,38-39H2,1-2H3,(H,66,79)(H,76,77)(H,67,75,78)/t47-,48-,52?/m1/s1","IIAPDULZKPEHMU-FPALUEFMSA-N"
"1120","P04035","HMGCR","CRBN","","P25A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","200","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1203.332","1202.53359192","4.68","87","8","19","6","37","293.46","C63H75FN8O15","InChI=1S/C63H75FN8O15/c1-41(2)58-57(61(79)66-45-10-4-3-5-11-45)55(59(42-16-18-44(64)19-17-42)71(58)24-22-47(73)38-48(74)39-54(76)77)43-9-6-13-49(37-43)87-26-8-12-46-40-70(69-68-46)25-28-83-30-32-85-34-36-86-35-33-84-31-29-82-27-23-65-51-15-7-14-50-56(51)63(81)72(62(50)80)52-20-21-53(75)67-60(52)78/h3-7,9-11,13-19,37,40-41,47-48,52,65,73-74H,8,12,20-36,38-39H2,1-2H3,(H,66,79)(H,76,77)(H,67,75,78)/t47-,48-,52?/m1/s1","JLBAXXGSFOPYED-FPALUEFMSA-N"
"1121","P04035","HMGCR","CRBN","","P26A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1217.359","1216.54924198","5.03","88","8","19","6","38","293.46","C64H77FN8O15","InChI=1S/C64H77FN8O15/c1-42(2)59-58(62(80)67-46-11-4-3-5-12-46)56(60(43-17-19-45(65)20-18-43)72(59)25-23-48(74)39-49(75)40-55(77)78)44-10-8-14-50(38-44)88-27-7-6-13-47-41-71(70-69-47)26-29-84-31-33-86-35-37-87-36-34-85-32-30-83-28-24-66-52-16-9-15-51-57(52)64(82)73(63(51)81)53-21-22-54(76)68-61(53)79/h3-5,8-12,14-20,38,41-42,48-49,53,66,74-75H,6-7,13,21-37,39-40H2,1-2H3,(H,67,80)(H,77,78)(H,68,76,79)/t48-,49-,53?/m1/s1","UVFPGFDLMAJEOI-MOHJDXDLSA-N"
"1122","P04035","HMGCR","CRBN","","P27A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","600","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1231.386","1230.56489205","5.39","89","8","19","6","39","293.46","C65H79FN8O15","InChI=1S/C65H79FN8O15/c1-43(2)60-59(63(81)68-47-12-5-3-6-13-47)57(61(44-18-20-46(66)21-19-44)73(60)26-24-49(75)40-50(76)41-56(78)79)45-11-9-15-51(39-45)89-28-8-4-7-14-48-42-72(71-70-48)27-30-85-32-34-87-36-38-88-37-35-86-33-31-84-29-25-67-53-17-10-16-52-58(53)65(83)74(64(52)82)54-22-23-55(77)69-62(54)80/h3,5-6,9-13,15-21,39,42-43,49-50,54,67,75-76H,4,7-8,14,22-38,40-41H2,1-2H3,(H,68,81)(H,78,79)(H,69,77,80)/t49-,50-,54?/m1/s1","TWQUUKPKPBHTJN-VTRKPICJSA-N"
"1123","P04035","HMGCR","CRBN","","P13A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1025.148","1024.44946837","6.56","75","8","14","6","25","247.31","C56H61FN8O10","InChI=1S/C56H61FN8O10/c1-34(2)51-50(54(72)59-38-14-7-6-8-15-38)48(52(35-19-21-37(57)22-20-35)64(51)28-25-40(66)30-41(67)31-47(69)70)36-13-11-16-42(29-36)75-33-39-32-63(62-61-39)27-10-5-3-4-9-26-58-44-18-12-17-43-49(44)56(74)65(55(43)73)45-23-24-46(68)60-53(45)71/h6-8,11-22,29,32,34,40-41,45,58,66-67H,3-5,9-10,23-28,30-31,33H2,1-2H3,(H,59,72)(H,69,70)(H,60,68,71)/t40-,41-,45?/m1/s1","MNHDUGMULBCGBO-WGFAKLPBSA-N"
"1124","P04035","HMGCR","CRBN","","P14A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","400","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1039.175","1038.46511844","6.84","76","8","14","6","26","247.31","C57H63FN8O10","InChI=1S/C57H63FN8O10/c1-35(2)52-51(55(73)60-39-14-6-5-7-15-39)49(53(36-20-22-38(58)23-21-36)65(52)29-26-41(67)32-42(68)33-48(70)71)37-13-10-17-43(31-37)76-30-12-16-40-34-64(63-62-40)28-9-4-3-8-27-59-45-19-11-18-44-50(45)57(75)66(56(44)74)46-24-25-47(69)61-54(46)72/h5-7,10-11,13-15,17-23,31,34-35,41-42,46,59,67-68H,3-4,8-9,12,16,24-30,32-33H2,1-2H3,(H,60,73)(H,70,71)(H,61,69,72)/t41-,42-,46?/m1/s1","ZSYCSQSVLORGPQ-RFIMGWBHSA-N"
"1125","P04035","HMGCR","CRBN","","P15A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","200","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1053.202","1052.4807685","7.38","77","8","14","6","27","247.31","C58H65FN8O10","InChI=1S/C58H65FN8O10/c1-36(2)53-52(56(74)61-40-15-7-6-8-16-40)50(54(37-21-23-39(59)24-22-37)66(53)30-27-42(68)33-43(69)34-49(71)72)38-14-11-18-44(32-38)77-31-13-17-41-35-65(64-63-41)29-10-5-3-4-9-28-60-46-20-12-19-45-51(46)58(76)67(57(45)75)47-25-26-48(70)62-55(47)73/h6-8,11-12,14-16,18-24,32,35-36,42-43,47,60,68-69H,3-5,9-10,13,17,25-31,33-34H2,1-2H3,(H,61,74)(H,71,72)(H,62,70,73)/t42-,43-,47?/m1/s1","SSIVFTARUYZQRR-VDKNZPKNSA-N"
"1126","P04035","HMGCR","CRBN","","P16A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","300","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1067.229","1066.49641856","7.74","78","8","14","6","28","247.31","C59H67FN8O10","InChI=1S/C59H67FN8O10/c1-37(2)54-53(57(75)62-41-16-7-6-8-17-41)51(55(38-22-24-40(60)25-23-38)67(54)31-28-43(69)34-44(70)35-50(72)73)39-15-13-19-45(33-39)78-32-12-9-18-42-36-66(65-64-42)30-11-5-3-4-10-29-61-47-21-14-20-46-52(47)59(77)68(58(46)76)48-26-27-49(71)63-56(48)74/h6-8,13-17,19-25,33,36-37,43-44,48,61,69-70H,3-5,9-12,18,26-32,34-35H2,1-2H3,(H,62,75)(H,72,73)(H,63,71,74)/t43-,44-,48?/m1/s1","QSIGDMGYYLASQS-OGVMARDASA-N"
"1127","P04035","HMGCR","CRBN","","P17A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","400","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1081.256","1080.51206863","8.1","79","8","14","6","29","247.31","C60H69FN8O10","InChI=1S/C60H69FN8O10/c1-38(2)55-54(58(76)63-42-17-8-6-9-18-42)52(56(39-23-25-41(61)26-24-39)68(55)32-29-44(70)35-45(71)36-51(73)74)40-16-14-20-46(34-40)79-33-13-7-10-19-43-37-67(66-65-43)31-12-5-3-4-11-30-62-48-22-15-21-47-53(48)60(78)69(59(47)77)49-27-28-50(72)64-57(49)75/h6,8-9,14-18,20-26,34,37-38,44-45,49,62,70-71H,3-5,7,10-13,19,27-33,35-36H2,1-2H3,(H,63,76)(H,73,74)(H,64,72,75)/t44-,45-,49?/m1/s1","LYZGJWGMLFFWSX-OEUTXLNUSA-N"
"1128","P04035","HMGCR","CRBN","","P18A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","300","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1095.283","1094.52771869","8.64","80","8","14","6","30","247.31","C61H71FN8O10","InChI=1S/C61H71FN8O10/c1-39(2)56-55(59(77)64-43-18-10-8-11-19-43)53(57(40-24-26-42(62)27-25-40)69(56)33-30-45(71)36-46(72)37-52(74)75)41-17-15-21-47(35-41)80-34-14-7-4-9-20-44-38-68(67-66-44)32-13-6-3-5-12-31-63-49-23-16-22-48-54(49)61(79)70(60(48)78)50-28-29-51(73)65-58(50)76/h8,10-11,15-19,21-27,35,38-39,45-46,50,63,71-72H,3-7,9,12-14,20,28-34,36-37H2,1-2H3,(H,64,77)(H,74,75)(H,65,73,76)/t45-,46-,50?/m1/s1","YLSNBWKVPICJNZ-SRQCOUMPSA-N"
"1129","P04035","HMGCR","CRBN","","P19A1","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCCCC3=CN(CCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","500","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1109.31","1108.54336876","9.18","81","8","14","6","31","247.31","C62H73FN8O10","InChI=1S/C62H73FN8O10/c1-40(2)57-56(60(78)65-44-19-11-9-12-20-44)54(58(41-25-27-43(63)28-26-41)70(57)34-31-46(72)37-47(73)38-53(75)76)42-18-16-22-48(36-42)81-35-15-8-3-5-10-21-45-39-69(68-67-45)33-14-7-4-6-13-32-64-50-24-17-23-49-55(50)62(80)71(61(49)79)51-29-30-52(74)66-59(51)77/h9,11-12,16-20,22-28,36,39-40,46-47,51,64,72-73H,3-8,10,13-15,21,29-35,37-38H2,1-2H3,(H,65,78)(H,75,76)(H,66,74,77)/t46-,47-,51?/m1/s1","CIOOKQVNPLZLAN-CFQHIMGQSA-N"
"1130","P04035","HMGCR","CRBN","","P19AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1115.226","1114.48116242","4.42","81","8","17","6","31","275.0","C59H67FN8O13","InChI=1S/C59H67FN8O13/c1-37(2)54-53(57(75)62-41-9-4-3-5-10-41)52(55(38-13-15-40(60)16-14-38)67(54)23-21-44(69)34-45(70)35-51(72)73)39-8-6-12-46(32-39)81-25-7-11-43-36-66(65-64-43)24-27-79-29-31-80-30-28-78-26-22-61-42-17-18-47-48(33-42)59(77)68(58(47)76)49-19-20-50(71)63-56(49)74/h3-6,8-10,12-18,32-33,36-37,44-45,49,61,69-70H,7,11,19-31,34-35H2,1-2H3,(H,62,75)(H,72,73)(H,63,71,74)/t44-,45-,49?/m1/s1","FLZOWPIEHOMVRX-OEUTXLNUSA-N"
"1131","P04035","HMGCR","CRBN","","P20AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1129.253","1128.49681249","4.78","82","8","17","6","32","275.0","C60H69FN8O13","InChI=1S/C60H69FN8O13/c1-38(2)55-54(58(76)63-42-10-4-3-5-11-42)53(56(39-14-16-41(61)17-15-39)68(55)24-22-45(70)35-46(71)36-52(73)74)40-9-8-13-47(33-40)82-26-7-6-12-44-37-67(66-65-44)25-28-80-30-32-81-31-29-79-27-23-62-43-18-19-48-49(34-43)60(78)69(59(48)77)50-20-21-51(72)64-57(50)75/h3-5,8-11,13-19,33-34,37-38,45-46,50,62,70-71H,6-7,12,20-32,35-36H2,1-2H3,(H,63,76)(H,73,74)(H,64,72,75)/t45-,46-,50?/m1/s1","SGYUWZDXRBHEKP-SRQCOUMPSA-N"
"1132","P04035","HMGCR","CRBN","","P21AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1143.28","1142.51246255","5.13","83","8","17","6","33","275.0","C61H71FN8O13","InChI=1S/C61H71FN8O13/c1-39(2)56-55(59(77)64-43-11-5-3-6-12-43)54(57(40-15-17-42(62)18-16-40)69(56)25-23-46(71)36-47(72)37-53(74)75)41-10-9-14-48(34-41)83-27-8-4-7-13-45-38-68(67-66-45)26-29-81-31-33-82-32-30-80-28-24-63-44-19-20-49-50(35-44)61(79)70(60(49)78)51-21-22-52(73)65-58(51)76/h3,5-6,9-12,14-20,34-35,38-39,46-47,51,63,71-72H,4,7-8,13,21-33,36-37H2,1-2H3,(H,64,77)(H,74,75)(H,65,73,76)/t46-,47-,51?/m1/s1","XSBGEHVFSGCQMH-CFQHIMGQSA-N"
"1133","P04035","HMGCR","CRBN","","P22AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","300","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1159.279","1158.50737717","4.27","84","8","18","6","34","284.23","C61H71FN8O14","InChI=1S/C61H71FN8O14/c1-39(2)56-55(59(77)64-43-9-4-3-5-10-43)54(57(40-13-15-42(62)16-14-40)69(56)23-21-46(71)36-47(72)37-53(74)75)41-8-6-12-48(34-41)84-25-7-11-45-38-68(67-66-45)24-27-81-29-31-83-33-32-82-30-28-80-26-22-63-44-17-18-49-50(35-44)61(79)70(60(49)78)51-19-20-52(73)65-58(51)76/h3-6,8-10,12-18,34-35,38-39,46-47,51,63,71-72H,7,11,19-33,36-37H2,1-2H3,(H,64,77)(H,74,75)(H,65,73,76)/t46-,47-,51?/m1/s1","FEPLBHREWCSACK-CFQHIMGQSA-N"
"1134","P04035","HMGCR","CRBN","","P23AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1173.306","1172.52302724","4.63","85","8","18","6","35","284.23","C62H73FN8O14","InChI=1S/C62H73FN8O14/c1-40(2)57-56(60(78)65-44-10-4-3-5-11-44)55(58(41-14-16-43(63)17-15-41)70(57)24-22-47(72)37-48(73)38-54(75)76)42-9-8-13-49(35-42)85-26-7-6-12-46-39-69(68-67-46)25-28-82-30-32-84-34-33-83-31-29-81-27-23-64-45-18-19-50-51(36-45)62(80)71(61(50)79)52-20-21-53(74)66-59(52)77/h3-5,8-11,13-19,35-36,39-40,47-48,52,64,72-73H,6-7,12,20-34,37-38H2,1-2H3,(H,65,78)(H,75,76)(H,66,74,77)/t47-,48-,52?/m1/s1","LKXPCVSVQQEPRK-FPALUEFMSA-N"
"1135","P04035","HMGCR","CRBN","","P24AM","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1187.333","1186.5386773","4.99","86","8","18","6","36","284.23","C63H75FN8O14","InChI=1S/C63H75FN8O14/c1-41(2)58-57(61(79)66-45-11-5-3-6-12-45)56(59(42-15-17-44(64)18-16-42)71(58)25-23-48(73)38-49(74)39-55(76)77)43-10-9-14-50(36-43)86-27-8-4-7-13-47-40-70(69-68-47)26-29-83-31-33-85-35-34-84-32-30-82-28-24-65-46-19-20-51-52(37-46)63(81)72(62(51)80)53-21-22-54(75)67-60(53)78/h3,5-6,9-12,14-20,36-37,40-41,48-49,53,65,73-74H,4,7-8,13,21-35,38-39H2,1-2H3,(H,66,79)(H,76,77)(H,67,75,78)/t48-,49-,53?/m1/s1","METKOBDLEKDPEQ-MOHJDXDLSA-N"
"1136","P04035","HMGCR","CRBN","","L13A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1008.117","1007.42291928","4.98","74","8","13","5","22","227.44","C56H58FN7O10","InChI=1S/C56H58FN7O10/c1-35(2)52-51(55(71)58-40-13-4-3-5-14-40)50(53(37-18-20-39(57)21-19-37)63(52)25-24-42(65)31-43(66)32-49(68)69)38-11-6-16-44(30-38)74-28-9-15-41-33-62(61-60-41)26-29-73-27-8-12-36-10-7-17-45-46(36)34-64(56(45)72)47-22-23-48(67)59-54(47)70/h3-7,10-11,13-14,16-21,30,33,35,42-43,47,65-66H,9,15,22-29,31-32,34H2,1-2H3,(H,58,71)(H,68,69)(H,59,67,70)/t42-,43-,47?/m1/s1","ICDOXFOPMPLNMJ-VDKNZPKNSA-N"
"1137","P04035","HMGCR","CRBN","","L14A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1022.144","1021.43856934","5.33","75","8","13","5","23","227.44","C57H60FN7O10","InChI=1S/C57H60FN7O10/c1-36(2)53-52(56(72)59-41-14-4-3-5-15-41)51(54(38-19-21-40(58)22-20-38)64(53)27-25-43(66)32-44(67)33-50(69)70)39-12-6-17-45(31-39)75-30-9-16-42-34-63(62-61-42)26-10-29-74-28-8-13-37-11-7-18-46-47(37)35-65(57(46)73)48-23-24-49(68)60-55(48)71/h3-7,11-12,14-15,17-22,31,34,36,43-44,48,66-67H,9-10,16,23-30,32-33,35H2,1-2H3,(H,59,72)(H,69,70)(H,60,68,71)/t43-,44-,48?/m1/s1","DVLGRXKVQLBKEM-OGVMARDASA-N"
"1138","P04035","HMGCR","CRBN","","L15A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1036.171","1035.4542194","5.69","76","8","13","5","24","227.44","C58H62FN7O10","InChI=1S/C58H62FN7O10/c1-37(2)54-53(57(73)60-42-15-4-3-5-16-42)52(55(39-20-22-41(59)23-21-39)65(54)28-26-44(67)33-45(68)34-51(70)71)40-13-8-18-46(32-40)76-31-11-17-43-35-64(63-62-43)27-6-7-29-75-30-10-14-38-12-9-19-47-48(38)36-66(58(47)74)49-24-25-50(69)61-56(49)72/h3-5,8-9,12-13,15-16,18-23,32,35,37,44-45,49,67-68H,6-7,11,17,24-31,33-34,36H2,1-2H3,(H,60,73)(H,70,71)(H,61,69,72)/t44-,45-,49?/m1/s1","USDKDQYXGONXDX-OEUTXLNUSA-N"
"1139","P04035","HMGCR","CRBN","","L16A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","300","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1050.198","1049.46986947","6.05","77","8","13","5","25","227.44","C59H64FN7O10","InChI=1S/C59H64FN7O10/c1-38(2)55-54(58(74)61-43-16-5-3-6-17-43)53(56(40-21-23-42(60)24-22-40)66(55)29-27-45(68)34-46(69)35-52(71)72)41-14-9-19-47(33-41)77-32-12-18-44-36-65(64-63-44)28-7-4-8-30-76-31-11-15-39-13-10-20-48-49(39)37-67(59(48)75)50-25-26-51(70)62-57(50)73/h3,5-6,9-10,13-14,16-17,19-24,33,36,38,45-46,50,68-69H,4,7-8,12,18,25-32,34-35,37H2,1-2H3,(H,61,74)(H,71,72)(H,62,70,73)/t45-,46-,50?/m1/s1","RXFBLQWZSSSQDX-SRQCOUMPSA-N"
"1140","P04035","HMGCR","CRBN","","L17A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCCCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","200","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1064.225","1063.48551953","6.41","78","8","13","5","26","227.44","C60H66FN7O10","InChI=1S/C60H66FN7O10/c1-39(2)56-55(59(75)62-44-17-6-5-7-18-44)54(57(41-22-24-43(61)25-23-41)67(56)30-28-46(69)35-47(70)36-53(72)73)42-15-10-20-48(34-42)78-33-13-19-45-37-66(65-64-45)29-8-3-4-9-31-77-32-12-16-40-14-11-21-49-50(40)38-68(60(49)76)51-26-27-52(71)63-58(51)74/h5-7,10-11,14-15,17-18,20-25,34,37,39,46-47,51,69-70H,3-4,8-9,13,19,26-33,35-36,38H2,1-2H3,(H,62,75)(H,72,73)(H,63,71,74)/t46-,47-,51?/m1/s1","XENQODBRMXLGFU-CFQHIMGQSA-N"
"1141","P04035","HMGCR","CRBN","","L18A","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCCCCCCOCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O","700","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1078.252","1077.5011696","6.95","79","8","13","5","27","227.44","C61H68FN7O10","InChI=1S/C61H68FN7O10/c1-40(2)57-56(60(76)63-45-18-7-6-8-19-45)55(58(42-23-25-44(62)26-24-42)68(57)31-29-47(70)36-48(71)37-54(73)74)43-16-11-21-49(35-43)79-34-14-20-46-38-67(66-65-46)30-9-4-3-5-10-32-78-33-13-17-41-15-12-22-50-51(41)39-69(61(50)77)52-27-28-53(72)64-59(52)75/h6-8,11-12,15-16,18-19,21-26,35,38,40,47-48,52,70-71H,3-5,9-10,14,20,27-34,36-37,39H2,1-2H3,(H,63,76)(H,73,74)(H,64,72,75)/t47-,48-,52?/m1/s1","UOMHGMSXAWPEFB-FPALUEFMSA-N"
"1142","P04035","HMGCR","CRBN","","L13AR","CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(C2=CC=CC(OCCCC3=CN(CCOCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)=C2)=C(C2=CC=C(F)C=C2)N1CC[C@@H](O)C[C@@H](O)CC(=O)O",">3000","","Degradation of HMGCR in SRD15 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00339","1012.149","1011.4542194","5.4","74","8","13","5","25","227.44","C56H62FN7O10","InChI=1S/C56H62FN7O10/c1-35(2)52-51(55(71)58-40-13-4-3-5-14-40)50(53(37-18-20-39(57)21-19-37)63(52)25-24-42(65)31-43(66)32-49(68)69)38-11-6-16-44(30-38)74-28-9-15-41-33-62(61-60-41)26-29-73-27-8-12-36-10-7-17-45-46(36)34-64(56(45)72)47-22-23-48(67)59-54(47)70/h3-7,10-11,13-14,16-21,30,33,35,42-43,47,65-66H,8-9,12,15,22-29,31-32,34H2,1-2H3,(H,58,71)(H,68,69)(H,59,67,70)/t42-,43-,47?/m1/s1","DMTQJVYKMUNQSL-VDKNZPKNSA-N"
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"1152","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01528","764.499","764.106715276","4.65","47","5","9","5","13","157.97","C31H28F3IN6O6","InChI=1S/C31H28F3IN6O6/c32-19-7-6-18(27(26(19)34)38-21-8-5-16(35)15-20(21)33)28(43)40-47-14-2-11-36-12-13-37-22-4-1-3-17-25(22)31(46)41(30(17)45)23-9-10-24(42)39-29(23)44/h1,3-8,15,23,36-38H,2,9-14H2,(H,40,43)(H,39,42,44)","RRMNATGTRRMSTA-UHFFFAOYSA-N"
"1152","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b01528","764.499","764.106715276","4.65","47","5","9","5","13","157.97","C31H28F3IN6O6","InChI=1S/C31H28F3IN6O6/c32-19-7-6-18(27(26(19)34)38-21-8-5-16(35)15-20(21)33)28(43)40-47-14-2-11-36-12-13-37-22-4-1-3-17-25(22)31(46)41(30(17)45)23-9-10-24(42)39-29(23)44/h1,3-8,15,23,36-38H,2,9-14H2,(H,40,43)(H,39,42,44)","RRMNATGTRRMSTA-UHFFFAOYSA-N"
"1153","P36507","MEK2","VHL","","MS432","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","17/9.3/11","","Degradation of MEK2 in HT-29/SK-MEL-28/COLO 205 cells after 24 h treatment","","","590","IC50 of MEK2 was tested using the HotSpot kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130/83/34","Inhibit proliferation of HT-29/SK-MEL-28/COLO 205 cells","","","","","","","","","","","10.1021/acs.jmedchem.9b01528","1076.078","1075.37138646","10.42","68","5","10","6","25","174.02","C50H65F3IN7O6S","InChI=1S/C50H65F3IN7O6S/c1-31(33-16-18-34(19-17-33)45-32(2)56-30-68-45)57-48(65)41-28-36(62)29-61(41)49(66)46(50(3,4)5)59-42(63)15-12-10-8-6-7-9-11-13-24-55-25-14-26-67-60-47(64)37-21-22-38(51)43(53)44(37)58-40-23-20-35(54)27-39(40)52/h16-23,27,30-31,36,41,46,55,58,62H,6-15,24-26,28-29H2,1-5H3,(H,57,65)(H,59,63)(H,60,64)/t31-,36+,41-,46+/m0/s1","KCBAMQOKOLXLOX-BSZYMOERSA-N"
"1153","Q02750","MEK1","VHL","","MS432","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","31/31/18","","Degradation of MEK1 in HT-29/SK-MEL-28/COLO 205 cells after 24 h treatment","","","1500","IC50 of MEK1 was tested using the HotSpot kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130/83/34","Inhibit proliferation of HT-29/SK-MEL-28/COLO 205 cells","","","","","","","","","","","10.1021/acs.jmedchem.9b01528","1076.078","1075.37138646","10.42","68","5","10","6","25","174.02","C50H65F3IN7O6S","InChI=1S/C50H65F3IN7O6S/c1-31(33-16-18-34(19-17-33)45-32(2)56-30-68-45)57-48(65)41-28-36(62)29-61(41)49(66)46(50(3,4)5)59-42(63)15-12-10-8-6-7-9-11-13-24-55-25-14-26-67-60-47(64)37-21-22-38(51)43(53)44(37)58-40-23-20-35(54)27-39(40)52/h16-23,27,30-31,36,41,46,55,58,62H,6-15,24-26,28-29H2,1-5H3,(H,57,65)(H,59,63)(H,60,64)/t31-,36+,41-,46+/m0/s1","KCBAMQOKOLXLOX-BSZYMOERSA-N"
"1154","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","3.41","88.01","Degradation of HDAC6 in MM1S cells after 6 h treatment","62.1/81.3","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","737.774","737.292159208","2.28","54","6","12","5","15","217.19","C37H39N9O8","InChI=1S/C37H39N9O8/c1-2-3-17-44(21-23-7-9-24(10-8-23)33(48)42-53)37(52)39-25-11-13-27(14-12-25)54-19-18-45-22-26(41-43-45)20-38-29-6-4-5-28-32(29)36(51)46(35(28)50)30-15-16-31(47)40-34(30)49/h4-14,22,30,38,53H,2-3,15-21H2,1H3,(H,39,52)(H,42,48)(H,40,47,49)","YVMSHPWOPPUCHZ-UHFFFAOYSA-N"
"1155","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","67.3/84.1","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","751.801","751.307809272","2.64","55","6","12","5","16","217.19","C38H41N9O8","InChI=1S/C38H41N9O8/c1-2-3-18-45(22-24-8-10-25(11-9-24)34(49)43-54)38(53)40-26-12-14-28(15-13-26)55-20-5-19-46-23-27(42-44-46)21-39-30-7-4-6-29-33(30)37(52)47(36(29)51)31-16-17-32(48)41-35(31)50/h4,6-15,23,31,39,54H,2-3,5,16-22H2,1H3,(H,40,53)(H,43,49)(H,41,48,50)","BCUINMHRBBUKKX-UHFFFAOYSA-N"
"1156","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","64.3/85","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","765.828","765.323459336","2.99","56","6","12","5","17","217.19","C39H43N9O8","InChI=1S/C39H43N9O8/c1-2-3-19-46(23-25-9-11-26(12-10-25)35(50)44-55)39(54)41-27-13-15-29(16-14-27)56-21-5-4-20-47-24-28(43-45-47)22-40-31-8-6-7-30-34(31)38(53)48(37(30)52)32-17-18-33(49)42-36(32)51/h6-16,24,32,40,55H,2-5,17-23H2,1H3,(H,41,54)(H,44,50)(H,42,49,51)","WTEQNAJWLZRTQJ-UHFFFAOYSA-N"
"1157","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","1.64","86.26","Degradation of HDAC6 in MM1S cells after 6 h treatment","74.9/82.7","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","8.7","IC50 of HDAC6 was determined using a fluorescence-based assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","74.9","Inhibit proliferation of MM1S cells","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","779.855","779.3391094","3.35","57","6","12","5","18","217.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-2-3-20-47(24-26-10-12-27(13-11-26)36(51)45-56)40(55)42-28-14-16-30(17-15-28)57-22-6-4-5-21-48-25-29(44-46-48)23-41-32-9-7-8-31-35(32)39(54)49(38(31)53)33-18-19-34(50)43-37(33)52/h7-17,25,33,41,56H,2-6,18-24H2,1H3,(H,42,55)(H,45,51)(H,43,50,52)","DQGQXFRCIYCGOE-UHFFFAOYSA-N"
"1157","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","2.2/18","86/45","Degradation of HDAC6 in MM1S/Mouse 4935 cells after 4/6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","74.9","Inhibit proliferation of MM1S cells","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00046","779.855","779.3391094","3.35","57","6","12","5","18","217.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-2-3-20-47(24-26-10-12-27(13-11-26)36(51)45-56)40(55)42-28-14-16-30(17-15-28)57-22-6-4-5-21-48-25-29(44-46-48)23-41-32-9-7-8-31-35(32)39(54)49(38(31)53)33-18-19-34(50)43-37(33)52/h7-17,25,33,41,56H,2-6,18-24H2,1H3,(H,42,55)(H,45,51)(H,43,50,52)","DQGQXFRCIYCGOE-UHFFFAOYSA-N"
"1158","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","66.1/77.8","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","793.882","793.354759464","3.71","58","6","12","5","19","217.19","C41H47N9O8","InChI=1S/C41H47N9O8/c1-2-3-21-48(25-27-11-13-28(14-12-27)37(52)46-57)41(56)43-29-15-17-31(18-16-29)58-23-7-5-4-6-22-49-26-30(45-47-49)24-42-33-10-8-9-32-36(33)40(55)50(39(32)54)34-19-20-35(51)44-38(34)53/h8-18,26,34,42,57H,2-7,19-25H2,1H3,(H,43,56)(H,46,52)(H,44,51,53)","XTVGDZXMUJCKHJ-UHFFFAOYSA-N"
"1159","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCN2C=C(CCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","49.3/81.8","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","751.801","751.307809272","2.74","55","6","12","5","16","217.19","C38H41N9O8","InChI=1S/C38H41N9O8/c1-2-3-19-45(22-24-7-9-25(10-8-24)34(49)43-54)38(53)40-26-11-13-28(14-12-26)55-21-20-46-23-27(42-44-46)17-18-39-30-6-4-5-29-33(30)37(52)47(36(29)51)31-15-16-32(48)41-35(31)50/h4-14,23,31,39,54H,2-3,15-22H2,1H3,(H,40,53)(H,43,49)(H,41,48,50)","HNMZDQNWKVLUEV-UHFFFAOYSA-N"
"1160","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCN2C=C(CCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","64.8/84.2","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","765.828","765.323459336","3.1","56","6","12","5","17","217.19","C39H43N9O8","InChI=1S/C39H43N9O8/c1-2-3-20-46(23-25-8-10-26(11-9-25)35(50)44-55)39(54)41-27-12-14-29(15-13-27)56-22-5-21-47-24-28(43-45-47)18-19-40-31-7-4-6-30-34(31)38(53)48(37(30)52)32-16-17-33(49)42-36(32)51/h4,6-15,24,32,40,55H,2-3,5,16-23H2,1H3,(H,41,54)(H,44,50)(H,42,49,51)","OFJLYSWADWFONC-UHFFFAOYSA-N"
"1161","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCN2C=C(CCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","71.7/79.2","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","779.855","779.3391094","3.45","57","6","12","5","18","217.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-2-3-21-47(24-26-9-11-27(12-10-26)36(51)45-56)40(55)42-28-13-15-30(16-14-28)57-23-5-4-22-48-25-29(44-46-48)19-20-41-32-8-6-7-31-35(32)39(54)49(38(31)53)33-17-18-34(50)43-37(33)52/h6-16,25,33,41,56H,2-5,17-24H2,1H3,(H,42,55)(H,45,51)(H,43,50,52)","WIOFXZIGATYRQF-UHFFFAOYSA-N"
"1162","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCN2C=C(CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","2.54","86.3","Degradation of HDAC6 in MM1S cells after 6 h treatment","70.6/83.1","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","765.828","765.323459336","3.1","56","6","12","5","17","217.19","C39H43N9O8","InChI=1S/C39H43N9O8/c1-2-3-20-46(23-25-9-11-26(12-10-25)35(50)44-55)39(54)41-27-13-15-29(16-14-27)56-22-21-47-24-28(43-45-47)6-5-19-40-31-8-4-7-30-34(31)38(53)48(37(30)52)32-17-18-33(49)42-36(32)51/h4,7-16,24,32,40,55H,2-3,5-6,17-23H2,1H3,(H,41,54)(H,44,50)(H,42,49,51)","HKHMBOOYLKOYAW-UHFFFAOYSA-N"
"1163","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCN2C=C(CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","45.6/77.3","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","779.855","779.3391094","3.45","57","6","12","5","18","217.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-2-3-21-47(24-26-10-12-27(13-11-26)36(51)45-56)40(55)42-28-14-16-30(17-15-28)57-23-6-22-48-25-29(44-46-48)7-5-20-41-32-9-4-8-31-35(32)39(54)49(38(31)53)33-18-19-34(50)43-37(33)52/h4,8-17,25,33,41,56H,2-3,5-7,18-24H2,1H3,(H,42,55)(H,45,51)(H,43,50,52)","IOEXOASXZJXISI-UHFFFAOYSA-N"
"1164","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCN2C=C(CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1","","","","50.9/75.7","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","793.882","793.354759464","3.81","58","6","12","5","19","217.19","C41H47N9O8","InChI=1S/C41H47N9O8/c1-2-3-22-48(25-27-11-13-28(14-12-27)37(52)46-57)41(56)43-29-15-17-31(18-16-29)58-24-5-4-23-49-26-30(45-47-49)8-7-21-42-33-10-6-9-32-36(33)40(55)50(39(32)54)34-19-20-35(51)44-38(34)53/h6,9-18,26,34,42,57H,2-5,7-8,19-25H2,1H3,(H,43,56)(H,46,52)(H,44,51,53)","BZYXYQCMBVHDMK-UHFFFAOYSA-N"
"1165","Q9UBN7","HDAC6","CRBN","","","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCN2C=C(CNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)N=N2)C=C1","","","","57.1/81.4","% HDAC6 degradation in MM1S cells after 6 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b00516","737.774","737.292159208","1.73","54","6","12","5","15","217.19","C37H39N9O8","InChI=1S/C37H39N9O8/c1-2-3-16-44(21-23-4-6-24(7-5-23)33(48)42-53)37(52)39-25-8-11-28(12-9-25)54-18-17-45-22-27(41-43-45)20-38-26-10-13-29-30(19-26)36(51)46(35(29)50)31-14-15-32(47)40-34(31)49/h4-13,19,22,31,38,53H,2-3,14-18,20-21H2,1H3,(H,39,52)(H,42,48)(H,40,47,49)","DUCAFNHYXLXMLW-UHFFFAOYSA-N"
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"1187","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=C2SC(C(=N)NC2CCS(=O)(=O)CC2)=C3)=CC=C1OCC(=O)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","13.5","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","48.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201611281","903.993","903.25676188","1.26","63","7","15","5","16","261.46","C42H45N7O12S2","InChI=1S/C42H45N7O12S2/c1-48-20-27(37-26(40(48)54)19-32(62-37)38(43)46-24-12-16-63(57,58)17-13-24)23-8-10-29(31(18-23)59-2)60-21-34(51)44-14-3-4-15-45-35(52)22-61-30-7-5-6-25-36(30)42(56)49(41(25)55)28-9-11-33(50)47-39(28)53/h5-8,10,18-20,24,28H,3-4,9,11-17,21-22H2,1-2H3,(H2,43,46)(H,44,51)(H,45,52)(H,47,50,53)","LOLHUPGCPDURJG-UHFFFAOYSA-N"
"1188","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=C2SC(C(=N)NC2CCS(=O)(=O)CC2)=C3)=CC=C1OCC(=O)NCCCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","18.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","43.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201611281","960.101","959.319362136","3.06","67","7","15","5","20","261.46","C46H53N7O12S2","InChI=1S/C46H53N7O12S2/c1-52-24-31(41-30(44(52)58)23-36(66-41)42(47)50-28-16-20-67(61,62)21-17-28)27-12-14-33(35(22-27)63-2)64-25-38(55)48-18-7-5-3-4-6-8-19-49-39(56)26-65-34-11-9-10-29-40(34)46(60)53(45(29)59)32-13-15-37(54)51-43(32)57/h9-12,14,22-24,28,32H,3-8,13,15-21,25-26H2,1-2H3,(H2,47,50)(H,48,55)(H,49,56)(H,51,54,57)","XAPSXVDWYVIBID-UHFFFAOYSA-N"
"1189","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=C2SC(C(=N)NC2CCS(=O)(=O)CC2)=C3)=CC=C1OCC(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","36.5","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","49.5","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201611281","1036.152","1035.33540612","0.81","72","7","18","5","25","289.15","C48H57N7O15S2","InChI=1S/C48H57N7O15S2/c1-54-26-33(43-32(46(54)60)25-38(71-43)44(49)52-30-12-22-72(63,64)23-13-30)29-8-10-35(37(24-29)65-2)69-27-40(57)50-14-4-16-66-18-20-68-21-19-67-17-5-15-51-41(58)28-70-36-7-3-6-31-42(36)48(62)55(47(31)61)34-9-11-39(56)53-45(34)59/h3,6-8,10,24-26,30,34H,4-5,9,11-23,27-28H2,1-2H3,(H2,49,52)(H,50,57)(H,51,58)(H,53,56,59)","QQDHYEORVFCZOL-UHFFFAOYSA-N"
"1190","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=C2SC(C(=N)NC2CCS(=O)(=O)CC2)=C3)=CC=C1OCC(=O)NCCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","30","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","20.1","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201611281","874.995","874.266598292","2.63","61","7","14","4","16","232.36","C42H46N6O11S2","InChI=1S/C42H46N6O11S2/c1-47-22-28(37-27(40(47)52)21-33(60-37)38(43)45-25-14-18-61(55,56)19-15-25)24-10-12-30(32(20-24)57-2)59-23-35(50)44-16-5-3-4-6-17-58-31-9-7-8-26-36(31)42(54)48(41(26)53)29-11-13-34(49)46-39(29)51/h7-10,12,20-22,25,29H,3-6,11,13-19,23H2,1-2H3,(H2,43,45)(H,44,50)(H,46,49,51)","KUQBYZITZXQWFL-UHFFFAOYSA-N"
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"1204","P24941","CDK2","CRBN","","TMX-1117","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","5.1","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","887.746","886.18678418","1.99","58","6","14","6","17","264.22","C36H40BrFN10O9S","InChI=1S/C36H40BrFN10O9S/c37-22-19-42-36(46-32(22)44-25-6-2-4-23(38)30(25)31(39)51)43-20-9-14-47(15-10-20)58(55,56)18-13-41-27(49)11-16-57-17-12-40-24-5-1-3-21-29(24)35(54)48(34(21)53)26-7-8-28(50)45-33(26)52/h1-6,19-20,26,40H,7-18H2,(H2,39,51)(H,41,49)(H,45,50,52)(H2,42,43,44,46)","HIDWZGVHAREHIX-UHFFFAOYSA-N"
"1205","P24941","CDK2","CRBN","","TMX-1128","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","4.9","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","932.783","931.197014516","1.28","61","6","15","5","20","270.65","C38H43BrFN9O11S","InChI=1S/C38H43BrFN9O11S/c39-24-21-43-38(47-34(24)45-26-5-2-4-25(40)32(26)33(41)52)44-22-9-13-48(14-10-22)61(56,57)20-12-42-29(50)11-15-58-16-17-59-18-19-60-28-6-1-3-23-31(28)37(55)49(36(23)54)27-7-8-30(51)46-35(27)53/h1-6,21-22,27H,7-20H2,(H2,41,52)(H,42,50)(H,46,51,53)(H2,43,44,45,47)","VXWDMHSGJUKYIH-UHFFFAOYSA-N"
"1206","P24941","CDK2","CRBN","","TMX-1111","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","6.4","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","1020.889","1019.24944401","0.98","67","6","17","5","26","289.11","C42H51BrFN9O13S","InChI=1S/C42H51BrFN9O13S/c43-28-25-47-42(51-38(28)49-30-5-2-4-29(44)36(30)37(45)56)48-26-9-13-52(14-10-26)67(60,61)24-12-46-33(54)11-15-62-16-17-63-18-19-64-20-21-65-22-23-66-32-6-1-3-27-35(32)41(59)53(40(27)58)31-7-8-34(55)50-39(31)57/h1-6,25-26,31H,7-24H2,(H2,45,56)(H,46,54)(H,50,55,57)(H2,47,48,49,51)","QWSKWTFDILWZDE-UHFFFAOYSA-N"
"1207","P24941","CDK2","CRBN","","TMX-1146","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","7.3","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","1197.101","1195.354303","0.39","79","6","21","5","38","326.03","C50H67BrFN9O17S","InChI=1S/C50H67BrFN9O17S/c51-36-33-55-50(59-46(36)57-38-5-2-4-37(52)44(38)45(53)64)56-34-9-13-60(14-10-34)79(68,69)32-12-54-41(62)11-15-70-16-17-71-18-19-72-20-21-73-22-23-74-24-25-75-26-27-76-28-29-77-30-31-78-40-6-1-3-35-43(40)49(67)61(48(35)66)39-7-8-42(63)58-47(39)65/h1-6,33-34,39H,7-32H2,(H2,53,64)(H,54,62)(H,58,63,65)(H2,55,56,57,59)","VLEXMESUINLIQB-UHFFFAOYSA-N"
"1208","P24941","CDK2","CRBN","","TMX-1169","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","20.5","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","886.758","885.191535212","2.65","58","6","13","5","17","252.19","C37H41BrFN9O9S","InChI=1S/C37H41BrFN9O9S/c38-23-20-42-37(46-33(23)44-25-8-5-7-24(39)31(25)32(40)51)43-21-13-16-47(17-14-21)58(55,56)19-15-41-28(49)10-2-1-3-18-57-27-9-4-6-22-30(27)36(54)48(35(22)53)26-11-12-29(50)45-34(26)52/h4-9,20-21,26H,1-3,10-19H2,(H2,40,51)(H,41,49)(H,45,50,52)(H2,42,43,44,46)","PNCTYDLOKOQJRO-UHFFFAOYSA-N"
"1209","P24941","CDK2","CRBN","","TMX-1162","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","17.1","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202004087","914.812","913.22283534","3.73","60","6","13","5","19","252.19","C39H45BrFN9O9S","InChI=1S/C39H45BrFN9O9S/c40-25-22-44-39(48-35(25)46-27-10-7-9-26(41)33(27)34(42)53)45-23-15-18-49(19-16-23)60(57,58)21-17-43-30(51)12-4-2-1-3-5-20-59-29-11-6-8-24-32(29)38(56)50(37(24)55)28-13-14-31(52)47-36(28)54/h6-11,22-23,28H,1-5,12-21H2,(H2,42,53)(H,43,51)(H,47,52,54)(H2,44,45,46,48)","BYFUWGZSJUCQQV-UHFFFAOYSA-N"
"1210","P24941","CDK2","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","28.7","IC50 of CDK2/cyclin A was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96.6/33.3/53","Inhibit growth of OVCAR8/OVSAHO/FUOV1 cells","","","","","","","10.1002/anie.202004087","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","P11802","CDK4","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","458","IC50 of CDK4/cyclin D1 was tested by the Adapta assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96.6/33.3/53","Inhibit growth of OVCAR8/OVSAHO/FUOV1 cells","","","","","","","10.1002/anie.202004087","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","Q00535","CDK5","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","16.1","IC50 of CDK5/p25 was tested by the Z'-LYTE assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96.6/33.3/53","Inhibit growth of OVCAR8/OVSAHO/FUOV1 cells","","","","","","","10.1002/anie.202004087","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","Q00534","CDK6","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","78","IC50 of CDK6/cyclin D1 was tested by the Adapta assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96.6/33.3/53","Inhibit growth of OVCAR8/OVSAHO/FUOV1 cells","","","","","","","10.1002/anie.202004087","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","O14965","AURKA","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","P06493","CDK1","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
"1210","P45983","MAPK8","CRBN","","TMX-1160","NC(=O)C1=C(F)C=CC=C1NC1=NC(NC2CCN(S(=O)(=O)CCNC(=O)CCCCCCCCOC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=NC=C1Br","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","928.839","927.238485404","4.27","61","6","13","5","20","252.19","C40H47BrFN9O9S","InChI=1S/C40H47BrFN9O9S/c41-26-23-45-40(49-36(26)47-28-11-8-10-27(42)34(28)35(43)54)46-24-16-19-50(20-17-24)61(58,59)22-18-44-31(52)13-5-3-1-2-4-6-21-60-30-12-7-9-25-33(30)39(57)51(38(25)56)29-14-15-32(53)48-37(29)55/h7-12,23-24,29H,1-6,13-22H2,(H2,43,54)(H,44,52)(H,48,53,55)(H2,45,46,47,49)","RVBRYNIJOYPZIA-UHFFFAOYSA-N"
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"1213","Q8TD19","NEK9","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1213","Q8TDR2","STK35","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1213","Q96GD4","AURKB","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1213","Q96PY6","NEK1","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1213","Q9BYT3","STK33","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
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"1213","Q9UHD2","TBK1","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1213","Q9Y616","IRAK3","CRBN","","TMX-2174","CC1=CC(NC2=NC=C(Br)C(NC3=CC=CC(F)=C3C(N)=O)=N2)=CC=C1S(=O)(=O)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","970.832","969.21266458","3.35","64","6","16","6","24","271.6","C41H45BrFN9O11S","InChI=1S/C41H45BrFN9O11S/c1-24-22-25(48-41-46-23-27(42)37(51-41)49-30-7-3-5-28(43)35(30)36(44)54)8-10-32(24)64(58,59)47-13-15-61-17-19-63-21-20-62-18-16-60-14-12-45-29-6-2-4-26-34(29)40(57)52(39(26)56)31-9-11-33(53)50-38(31)55/h2-8,10,22-23,31,45,47H,9,11-21H2,1H3,(H2,44,54)(H,50,53,55)(H2,46,48,49,51)","JVMUJMDAZUXTJQ-UHFFFAOYSA-N"
"1214","O60885","BRD4","CRBN","","","CCS(=O)(=O)NC1=CC=C(OC2=CC=C(F)C=C2F)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CN(CCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N2)[NH]3)=C1","","","","","","2.7","IC50 of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","165/4090/6470","Inhibit proliferation of BxPC3/DLD-1/HCT-116 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.103817","926.916","926.26176492","0.73","66","8","14","5","16","257.81","C43H40F2N10O10S","InChI=1S/C43H40F2N10O10S/c1-3-66(62,63)51-24-8-11-35(65-36-10-7-23(44)15-31(36)45)27(16-24)29-20-53(2)43(61)39-28(29)17-33(48-39)40(58)46-18-25-19-54(52-50-25)13-14-64-22-38(57)47-32-6-4-5-26-30(32)21-55(42(26)60)34-9-12-37(56)49-41(34)59/h4-8,10-11,15-17,19-20,34,48,51H,3,9,12-14,18,21-22H2,1-2H3,(H,46,58)(H,47,57)(H,49,56,59)","OCIQBTCUSJZXTD-UHFFFAOYSA-N"
"1215","O60885","BRD4","CRBN","","","CCS(=O)(=O)NC1=CC=C(OC2=CC=C(F)C=C2F)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CN(CCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N2)[NH]3)=C1","","","","","","3.4","IC50 of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","245/5960/2220","Inhibit proliferation of BxPC3/DLD-1/HCT-116 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.103817","970.969","970.287979668","0.59","69","8","15","5","19","267.04","C45H44F2N10O11S","InChI=1S/C45H44F2N10O11S/c1-3-69(64,65)53-26-8-11-37(68-38-10-7-25(46)17-33(38)47)29(18-26)31-22-55(2)45(63)41-30(31)19-35(50-41)42(60)48-20-27-21-56(54-52-27)13-14-66-15-16-67-24-40(59)49-34-6-4-5-28-32(34)23-57(44(28)62)36-9-12-39(58)51-43(36)61/h4-8,10-11,17-19,21-22,36,50,53H,3,9,12-16,20,23-24H2,1-2H3,(H,48,60)(H,49,59)(H,51,58,61)","CTSOQZLNQMKNFT-UHFFFAOYSA-N"
"1216","O60885","BRD4","CRBN","","","CCS(=O)(=O)NC1=CC=C(OC2=CC=C(F)C=C2F)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CN(CCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N2)[NH]3)=C1","","","","","","3.7","IC50 of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4138/2040/4390","Inhibit proliferation of BxPC3/DLD-1/HCT-116 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.103817","1015.022","1014.31419442","0.44","72","8","16","5","22","276.27","C47H48F2N10O12S","InChI=1S/C47H48F2N10O12S/c1-3-72(66,67)55-28-8-11-39(71-40-10-7-27(48)19-35(40)49)31(20-28)33-24-57(2)47(65)43-32(33)21-37(52-43)44(62)50-22-29-23-58(56-54-29)13-14-68-15-16-69-17-18-70-26-42(61)51-36-6-4-5-30-34(36)25-59(46(30)64)38-9-12-41(60)53-45(38)63/h4-8,10-11,19-21,23-24,38,52,55H,3,9,12-18,22,25-26H2,1-2H3,(H,50,62)(H,51,61)(H,53,60,63)","KLSSHHHRIKNTPE-UHFFFAOYSA-N"
"1217","O60885","BRD4","CRBN","","","CCS(=O)(=O)NC1=CC=C(OC2=CC=C(F)C=C2F)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CN(CCOCCOCCOCCOCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N2)[NH]3)=C1","","","","","","12","IC50 of BRD4 BD1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000/>10000","Inhibit proliferation of BxPC3/DLD-1/HCT-116 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.103817","1059.075","1058.34040916","0.29","75","8","17","5","25","285.5","C49H52F2N10O13S","InChI=1S/C49H52F2N10O13S/c1-3-75(68,69)57-30-8-11-41(74-42-10-7-29(50)21-37(42)51)33(22-30)35-26-59(2)49(67)45-34(35)23-39(54-45)46(64)52-24-31-25-60(58-56-31)13-14-70-15-16-71-17-18-72-19-20-73-28-44(63)53-38-6-4-5-32-36(38)27-61(48(32)66)40-9-12-43(62)55-47(40)65/h4-8,10-11,21-23,25-26,40,54,57H,3,9,12-20,24,27-28H2,1-2H3,(H,52,64)(H,53,63)(H,55,62,65)","RSOBNYDBEYGKRU-UHFFFAOYSA-N"
"1218","P00533","EGFR","CRBN","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CCOCCOCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1425/1874/1388","Inhibit proliferation of PC9/HCC827/H1975 cells","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127167","872.984","872.396958624","2.58","64","7","14","4","20","201.59","C46H52N10O8","InChI=1S/C46H52N10O8/c1-6-41(57)49-35-24-36(51-46-47-17-16-34(50-46)31-26-55(4)37-13-8-7-10-29(31)37)40(62-5)25-39(35)54(3)19-18-53(2)20-21-63-22-23-64-28-43(59)48-33-12-9-11-30-32(33)27-56(45(30)61)38-14-15-42(58)52-44(38)60/h6-13,16-17,24-26,38H,1,14-15,18-23,27-28H2,2-5H3,(H,48,59)(H,49,57)(H,47,50,51)(H,52,58,60)","WOALWHLORCCRQM-UHFFFAOYSA-N"
"1219","P00533","EGFR","CRBN","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CCOCCOCCOCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1117/1611/1698","Inhibit proliferation of PC9/HCC827/H1975 cells","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127167","917.037","916.423173372","2.44","67","7","15","4","23","210.82","C48H56N10O9","InChI=1S/C48H56N10O9/c1-6-43(59)51-37-26-38(53-48-49-17-16-36(52-48)33-28-57(4)39-13-8-7-10-31(33)39)42(64-5)27-41(37)56(3)19-18-55(2)20-21-65-22-23-66-24-25-67-30-45(61)50-35-12-9-11-32-34(35)29-58(47(32)63)40-14-15-44(60)54-46(40)62/h6-13,16-17,26-28,40H,1,14-15,18-25,29-30H2,2-5H3,(H,50,61)(H,51,59)(H,49,52,53)(H,54,60,62)","SLRLENALOHTBGF-UHFFFAOYSA-N"
"1220","P00533","EGFR","CRBN","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CCOCCOCCOCCOCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","161","68","Degradation of EGFR in PC9 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","413/1344/657","Inhibit proliferation of PC9/HCC827/H1975 cells","","","","","","","","","","","","","","","10.1016/j.bmcl.2020.127167","961.09","960.44938812","2.29","70","7","16","4","26","220.05","C50H60N10O10","InChI=1S/C50H60N10O10/c1-6-45(61)53-39-28-40(55-50-51-17-16-38(54-50)35-30-59(4)41-13-8-7-10-33(35)41)44(66-5)29-43(39)58(3)19-18-57(2)20-21-67-22-23-68-24-25-69-26-27-70-32-47(63)52-37-12-9-11-34-36(37)31-60(49(34)65)42-14-15-46(62)56-48(42)64/h6-13,16-17,28-30,42H,1,14-15,18-27,31-32H2,2-5H3,(H,52,63)(H,53,61)(H,51,54,55)(H,56,62,64)","MVXHKLZUALKPTB-UHFFFAOYSA-N"
"1221","P25440","BRD2","CRBN","","BETd-246","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCOCCOCCOCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.878/3.328","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","946.035","945.41333696","4.56","69","9","17","5","23","259.05","C48H55N11O10","InChI=1S/C48H55N11O10/c1-5-58-37(25-33(56-58)28-11-12-28)52-43-41-30-24-36(65-4)31(39-26(2)57-69-27(39)3)23-34(30)51-42(41)54-44(55-43)46(62)50-16-8-18-67-20-22-68-21-19-66-17-7-15-49-32-10-6-9-29-40(32)48(64)59(47(29)63)35-13-14-38(60)53-45(35)61/h6,9-10,23-25,28,35,49H,5,7-8,11-22H2,1-4H3,(H,50,62)(H,53,60,61)(H2,51,52,54,55)","XEJMFVWHCPNMRS-UHFFFAOYSA-N"
"1221","Q15059","BRD3","CRBN","","BETd-246","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCOCCOCCOCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.878/3.328","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","946.035","945.41333696","4.56","69","9","17","5","23","259.05","C48H55N11O10","InChI=1S/C48H55N11O10/c1-5-58-37(25-33(56-58)28-11-12-28)52-43-41-30-24-36(65-4)31(39-26(2)57-69-27(39)3)23-34(30)51-42(41)54-44(55-43)46(62)50-16-8-18-67-20-22-68-21-19-66-17-7-15-49-32-10-6-9-29-40(32)48(64)59(47(29)63)35-13-14-38(60)53-45(35)61/h6,9-10,23-25,28,35,49H,5,7-8,11-22H2,1-4H3,(H,50,62)(H,53,60,61)(H2,51,52,54,55)","XEJMFVWHCPNMRS-UHFFFAOYSA-N"
"1221","O60885","BRD4","CRBN","","BETd-246","CCN1N=C(C2CC2)C=C1NC1=NC(C(=O)NCCCOCCOCCOCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=NC2=C1C1=CC(OC)=C(C3=C(C)ON=C3C)C=C1[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.878/3.328","Inhibit viability of MDA-MB-468/MDA-MB-231 cells","","","","","","","","","","","","","10.1158/0008-5472.CAN-16-2622","946.035","945.41333696","4.56","69","9","17","5","23","259.05","C48H55N11O10","InChI=1S/C48H55N11O10/c1-5-58-37(25-33(56-58)28-11-12-28)52-43-41-30-24-36(65-4)31(39-26(2)57-69-27(39)3)23-34(30)51-42(41)54-44(55-43)46(62)50-16-8-18-67-20-22-68-21-19-66-17-7-15-49-32-10-6-9-29-40(32)48(64)59(47(29)63)35-13-14-38(60)53-45(35)61/h6,9-10,23-25,28,35,49H,5,7-8,11-22H2,1-4H3,(H,50,62)(H,53,60,61)(H2,51,52,54,55)","XEJMFVWHCPNMRS-UHFFFAOYSA-N"
"1222","Q06187","BTK","CRBN","","DD-03-007","CC1=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=CC=C1C1=CN(C)C(=O)C(NC2=CC=C(C(=O)N3CCN(CCOCCOCCNC(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=N1","","","","","","5.6","IC50 of BTK was tested by the FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","44.3/193/203","Inhibit proliferation of TMD8/Maver-1/Granta-519 cells","","","","","","","","","10.1182/blood-2018-07-862953","1023.161","1022.46503818","4.11","75","8","15","5","19","242.71","C55H62N10O10","InChI=1S/C55H62N10O10/c1-34-39(8-6-10-41(34)60-49(68)35-12-16-37(17-13-35)55(2,3)4)43-33-62(5)54(73)48(59-43)58-38-18-14-36(15-19-38)51(70)64-25-23-63(24-26-64)27-29-75-31-30-74-28-22-56-46(67)32-57-42-11-7-9-40-47(42)53(72)65(52(40)71)44-20-21-45(66)61-50(44)69/h6-19,33,44,57H,20-32H2,1-5H3,(H,56,67)(H,58,59)(H,60,68)(H,61,66,69)","WJTPGDDRKBADCH-UHFFFAOYSA-N"
"1222","Q06187","BTK C481S","CRBN","","DD-03-007","CC1=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=CC=C1C1=CN(C)C(=O)C(NC2=CC=C(C(=O)N3CCN(CCOCCOCCNC(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","149","Inhibit proliferation of TMD8 cells with C481S BTK","","","","","","","","","10.1182/blood-2018-07-862953","1023.161","1022.46503818","4.11","75","8","15","5","19","242.71","C55H62N10O10","InChI=1S/C55H62N10O10/c1-34-39(8-6-10-41(34)60-49(68)35-12-16-37(17-13-35)55(2,3)4)43-33-62(5)54(73)48(59-43)58-38-18-14-36(15-19-38)51(70)64-25-23-63(24-26-64)27-29-75-31-30-74-28-22-56-46(67)32-57-42-11-7-9-40-47(42)53(72)65(52(40)71)44-20-21-45(66)61-50(44)69/h6-19,33,44,57H,20-32H2,1-5H3,(H,56,67)(H,58,59)(H,60,68)(H,61,66,69)","WJTPGDDRKBADCH-UHFFFAOYSA-N"
"1223","Q06187","BTK","CRBN","","DD-03-171","CC1=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=CC=C1C1=CN(C)C(=O)C(NC2=CC=C(C(=O)N3CCN(CCCCCCNC(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=N1","","","","","","5.1","IC50 of BTK was tested by the FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12/29.2/47.7","Inhibit proliferation of Mino/TMD8/Maver-1 cells","","","","","","","","","10.1182/blood-2018-07-862953","991.163","990.475208944","5.83","73","8","13","5","17","224.25","C55H62N10O8","InChI=1S/C55H62N10O8/c1-34-39(12-10-14-41(34)60-49(68)35-16-20-37(21-17-35)55(2,3)4)43-33-62(5)54(73)48(59-43)58-38-22-18-36(19-23-38)51(70)64-30-28-63(29-31-64)27-9-7-6-8-26-56-46(67)32-57-42-15-11-13-40-47(42)53(72)65(52(40)71)44-24-25-45(66)61-50(44)69/h10-23,33,44,57H,6-9,24-32H2,1-5H3,(H,56,67)(H,58,59)(H,60,68)(H,61,66,69)","QBPVFCNYKUENHU-UHFFFAOYSA-N"
"1223","Q06187","BTK C481S","CRBN","","DD-03-171","CC1=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=CC=C1C1=CN(C)C(=O)C(NC2=CC=C(C(=O)N3CCN(CCCCCCNC(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","128","Inhibit proliferation of TMD8 cells with C481S BTK","","","","","","","","","10.1182/blood-2018-07-862953","991.163","990.475208944","5.83","73","8","13","5","17","224.25","C55H62N10O8","InChI=1S/C55H62N10O8/c1-34-39(12-10-14-41(34)60-49(68)35-16-20-37(21-17-35)55(2,3)4)43-33-62(5)54(73)48(59-43)58-38-22-18-36(19-23-38)51(70)64-30-28-63(29-31-64)27-9-7-6-8-26-56-46(67)32-57-42-15-11-13-40-47(42)53(72)65(52(40)71)44-24-25-45(66)61-50(44)69/h10-23,33,44,57H,6-9,24-32H2,1-5H3,(H,56,67)(H,58,59)(H,60,68)(H,61,66,69)","QBPVFCNYKUENHU-UHFFFAOYSA-N"
"1224","Q06187","BTK","CRBN","","DD-04-118","CC1=C(NC(=O)C2=CC=C(C(C)(C)C)C=C2)C=CC=C1C1=CN(C)C(=O)C(NC2=CC=C(C(=O)N3CCN(CCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=N1","","","","","","4.1","IC50 of BTK was tested by the FRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","69","Inhibit proliferation of Mino cells","","","","","","","","","10.1182/blood-2018-07-862953","992.147","991.459224532","5.27","73","8","13","4","17","221.45","C55H61N9O9","InChI=1S/C55H61N9O9/c1-34-39(12-10-14-41(34)59-49(67)35-16-20-37(21-17-35)55(2,3)4)42-32-61(5)54(72)48(58-42)57-38-22-18-36(19-23-38)51(69)63-30-28-62(29-31-63)27-9-7-6-8-26-56-46(66)33-73-44-15-11-13-40-47(44)53(71)64(52(40)70)43-24-25-45(65)60-50(43)68/h10-23,32,43H,6-9,24-31,33H2,1-5H3,(H,56,66)(H,57,58)(H,59,67)(H,60,65,68)","AHCLMQBWEKUSQP-UHFFFAOYSA-N"
"1225","P19634","SLC9A1","CRBN","","d9A-1","CC1=CC(C2=CC=C(C(=O)NCCOCCOCCOCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2N2CCC(C3=C(C)N=C[NH]3)CC2)=CC=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.003","881.959","881.375969084","3.0","64","7","12","4","20","210.59","C46H52FN7O10","InChI=1S/C46H52FN7O10/c1-28-24-31(7-9-35(28)47)33-8-6-32(25-37(33)53-16-12-30(13-17-53)42-29(2)50-27-51-42)43(57)49-15-19-62-21-23-63-22-20-61-18-14-48-40(56)26-64-38-5-3-4-34-41(38)46(60)54(45(34)59)36-10-11-39(55)52-44(36)58/h3-9,24-25,27,30,36H,10-23,26H2,1-2H3,(H,48,56)(H,49,57)(H,50,51)(H,52,55,58)","FFZKONSEIMSMBL-UHFFFAOYSA-N"
"1226","P19634","SLC9A1","CRBN","","d9A-2","CC1=CC(C2=CC=C(C(=O)NCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2N2CCC(C3=C(C)N=C[NH]3)CC2)=CC=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.003","867.976","867.396704528","4.07","63","7","12","4","21","193.52","C46H54FN7O9","InChI=1S/C46H54FN7O9/c1-29-26-32(7-9-36(29)47)34-8-6-33(27-39(34)53-16-12-31(13-17-53)42-30(2)50-28-51-42)43(56)49-15-19-61-21-23-63-25-24-62-22-20-60-18-14-48-37-5-3-4-35-41(37)46(59)54(45(35)58)38-10-11-40(55)52-44(38)57/h3-9,26-28,31,38,48H,10-25H2,1-2H3,(H,49,56)(H,50,51)(H,52,55,57)","WMBSSRAFHKGIRA-UHFFFAOYSA-N"
"1226","Q9UBY0","SLC9A2","CRBN","","d9A-2","CC1=CC(C2=CC=C(C(=O)NCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2N2CCC(C3=C(C)N=C[NH]3)CC2)=CC=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.003","867.976","867.396704528","4.07","63","7","12","4","21","193.52","C46H54FN7O9","InChI=1S/C46H54FN7O9/c1-29-26-32(7-9-36(29)47)34-8-6-33(27-39(34)53-16-12-31(13-17-53)42-30(2)50-28-51-42)43(56)49-15-19-61-21-23-63-25-24-62-22-20-60-18-14-48-37-5-3-4-35-41(37)46(59)54(45(35)58)38-10-11-40(55)52-44(38)57/h3-9,26-28,31,38,48H,10-25H2,1-2H3,(H,49,56)(H,50,51)(H,52,55,57)","WMBSSRAFHKGIRA-UHFFFAOYSA-N"
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"1241","P30291","Wee1","CRBN","","ZNL-02-012","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC(=O)CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","7.28","IC50 was tested using the FRET-based LanthaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.10.013","959.078","958.444971436","2.85","70","8","18","5","22","247.48","C49H58N12O9","InChI=1S/C49H58N12O9/c1-4-21-59-45(65)35-31-52-48(56-43(35)61(59)39-11-6-10-38(54-39)49(2,3)68)53-32-12-14-33(15-13-32)58-25-23-57(24-26-58)22-7-19-51-40(62)18-27-69-29-30-70-28-20-50-36-9-5-8-34-42(36)47(67)60(46(34)66)37-16-17-41(63)55-44(37)64/h4-6,8-15,31,37,50,68H,1,7,16-30H2,2-3H3,(H,51,62)(H,52,53,56)(H,55,63,64)","NHIWHRKKGDYXOD-UHFFFAOYSA-N"
"1242","P30291","Wee1","CRBN","","ZNL-02-047","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","3.18","IC50 was tested using the FRET-based LanthaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.10.013","918.025","917.41842234","3.09","67","8","18","4","21","227.61","C47H55N11O9","InChI=1S/C47H55N11O9/c1-4-18-56-43(61)34-30-49-46(53-41(34)58(56)38-10-6-9-37(51-38)47(2,3)64)50-31-11-13-32(14-12-31)55-21-19-54(20-22-55)23-25-66-27-29-67-28-26-65-24-17-48-35-8-5-7-33-40(35)45(63)57(44(33)62)36-15-16-39(59)52-42(36)60/h4-14,30,36,48,64H,1,15-29H2,2-3H3,(H,49,50,53)(H,52,59,60)","DJSFTHSIUXGJCR-UHFFFAOYSA-N"
"1243","P30291","Wee1","CRBN","","ZNL-02-040","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","4.46","IC50 was tested using the FRET-based LanthaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.10.013","841.974","841.402378352","4.96","62","8","15","4","16","199.92","C45H51N11O6","InChI=1S/C45H51N11O6/c1-4-22-54-41(59)32-28-47-44(51-39(32)56(54)36-14-10-13-35(49-36)45(2,3)62)48-29-15-17-30(18-16-29)53-26-24-52(25-27-53)23-8-6-5-7-21-46-33-12-9-11-31-38(33)43(61)55(42(31)60)34-19-20-37(57)50-40(34)58/h4,9-18,28,34,46,62H,1,5-8,19-27H2,2-3H3,(H,47,48,51)(H,50,57,58)","SCNBREAWLBQCQQ-UHFFFAOYSA-N"
"1244","P30291","Wee1","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","3.58","IC50 was tested using the FRET-based LanthaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","390","Inhibit proliferation of MOLT4 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2019.10.013","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","O96013","PAK4","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","P41743","PRKCI","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q15118","PDK1","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q15119","PDK2","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q15120","PDK3","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q8NI60","COQ8A","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q8TEA7","TBCK","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1244","Q9HBH9","MKNK2","CRBN","","ZNL-02-096","C=CCN1C(=O)C2=CN=C(NC3=CC=C(N4CCN(CCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N=C2N1C1=CC=CC(C(C)(C)O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","799.893","799.35542816","3.89","59","8","15","4","13","199.92","C42H45N11O6","InChI=1S/C42H45N11O6/c1-4-19-51-38(56)29-25-44-41(48-36(29)53(51)33-11-6-10-32(46-33)42(2,3)59)45-26-12-14-27(15-13-26)50-23-21-49(22-24-50)20-7-18-43-30-9-5-8-28-35(30)40(58)52(39(28)57)31-16-17-34(54)47-37(31)55/h4-6,8-15,25,31,43,59H,1,7,16-24H2,2-3H3,(H,44,45,48)(H,47,54,55)","LZUDSNUROXNVPH-UHFFFAOYSA-N"
"1245","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC=C(CN3CCCCC3C(=O)NCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Br)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","905.847","904.279524628","5.3","62","7","9","4","16","183.32","C47H49BrN6O8","InChI=1S/C47H49BrN6O8/c1-29-32(12-7-13-33(29)31-10-3-2-4-11-31)28-62-39-21-19-30(26-35(39)48)27-53-25-6-5-16-37(53)44(58)50-24-23-49-40(55)17-9-18-41(56)51-36-15-8-14-34-43(36)47(61)54(46(34)60)38-20-22-42(57)52-45(38)59/h2-4,7-8,10-15,19,21,26,37-38H,5-6,9,16-18,20,22-25,27-28H2,1H3,(H,49,55)(H,50,58)(H,51,56)(H,52,57,59)","FBCJICWWIKXIAA-UHFFFAOYSA-N"
"1246","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC=C(CN3CCCCC3C(=O)N3CCN(C(=O)CCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2Br)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","931.885","930.295174692","5.44","64","8","9","2","13","165.74","C49H51BrN6O8","InChI=1S/C49H51BrN6O8/c1-31-34(12-7-13-35(31)33-10-3-2-4-11-33)30-64-41-21-19-32(28-37(41)50)29-55-23-6-5-16-40(55)48(62)54-26-24-53(25-27-54)44(59)18-9-17-42(57)51-38-15-8-14-36-45(38)49(63)56(47(36)61)39-20-22-43(58)52-46(39)60/h2-4,7-8,10-15,19,21,28,39-40H,5-6,9,16-18,20,22-27,29-30H2,1H3,(H,51,57)(H,52,58,60)","DVGUKTMKOVUSFP-UHFFFAOYSA-N"
"1247","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC=C(CN3CCCCC3C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Br)C=CC=C1C1=CC=CC=C1","","","","","","197.4","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","820.785","819.263146292","7.28","56","7","8","3","14","137.15","C44H46BrN5O6","InChI=1S/C44H46BrN5O6/c1-28-31(13-9-14-32(28)30-11-3-2-4-12-30)27-56-38-20-18-29(25-34(38)45)26-49-24-8-5-17-36(49)41(52)47-23-7-6-22-46-35-16-10-15-33-40(35)44(55)50(43(33)54)37-19-21-39(51)48-42(37)53/h2-4,9-16,18,20,25,36-37,46H,5-8,17,19,21-24,26-27H2,1H3,(H,47,52)(H,48,51,53)","JPNHWPLRVODHHH-UHFFFAOYSA-N"
"1248","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","122.5","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","992.53","991.367153988","6.42","72","8","11","4","19","216.34","C55H54ClN7O9","InChI=1S/C55H54ClN7O9/c1-34-38(15-8-16-40(34)37-13-3-2-4-14-37)33-72-47-29-46(71-32-36-12-7-11-35(27-36)30-57)39(28-42(47)56)31-62-26-6-5-19-44(62)52(67)59-25-24-58-48(64)20-10-21-49(65)60-43-18-9-17-41-51(43)55(70)63(54(41)69)45-22-23-50(66)61-53(45)68/h2-4,7-9,11-18,27-29,44-45H,5-6,10,19-26,31-33H2,1H3,(H,58,64)(H,59,67)(H,60,65)(H,61,66,68)","IBGWLSYPVQSCKO-UHFFFAOYSA-N"
"1249","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","120.8","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1020.584","1019.39845412","7.13","74","8","11","4","21","216.34","C57H58ClN7O9","InChI=1S/C57H58ClN7O9/c1-36-40(17-10-18-42(36)39-15-3-2-4-16-39)35-74-49-31-48(73-34-38-14-9-13-37(29-38)32-59)41(30-44(49)58)33-64-28-8-5-21-46(64)54(69)61-27-7-6-26-60-50(66)22-12-23-51(67)62-45-20-11-19-43-53(45)57(72)65(56(43)71)47-24-25-52(68)63-55(47)70/h2-4,9-11,13-20,29-31,46-47H,5-8,12,21-28,33-35H2,1H3,(H,60,66)(H,61,69)(H,62,67)(H,63,68,70)","MHQSWUKMILRRKQ-UHFFFAOYSA-N"
"1250","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1006.557","1005.38280405","6.77","73","8","11","4","20","216.34","C56H56ClN7O9","InChI=1S/C56H56ClN7O9/c1-35-39(16-8-17-41(35)38-14-3-2-4-15-38)34-73-48-30-47(72-33-37-13-7-12-36(28-37)31-58)40(29-43(48)57)32-63-27-6-5-20-45(63)53(68)60-26-11-25-59-49(65)21-10-22-50(66)61-44-19-9-18-42-52(44)56(71)64(55(42)70)46-23-24-51(67)62-54(46)69/h2-4,7-9,12-19,28-30,45-46H,5-6,10-11,20-27,32-34H2,1H3,(H,59,65)(H,60,68)(H,61,66)(H,62,67,69)","QVMCSZVCGQFZSQ-UHFFFAOYSA-N"
"1251","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1034.611","1033.41410418","7.49","75","8","11","4","22","216.34","C58H60ClN7O9","InChI=1S/C58H60ClN7O9/c1-37-41(18-11-19-43(37)40-16-4-2-5-17-40)36-75-50-32-49(74-35-39-15-10-14-38(30-39)33-60)42(31-45(50)59)34-65-29-9-6-22-47(65)55(70)62-28-8-3-7-27-61-51(67)23-13-24-52(68)63-46-21-12-20-44-54(46)58(73)66(57(44)72)48-25-26-53(69)64-56(48)71/h2,4-5,10-12,14-21,30-32,47-48H,3,6-9,13,22-29,34-36H2,1H3,(H,61,67)(H,62,70)(H,63,68)(H,64,69,71)","MWDUACUKYPCNHO-UHFFFAOYSA-N"
"1252","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCCC(=O)NC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","101.9","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","992.53","991.367153988","5.87","72","8","11","4","19","216.34","C55H54ClN7O9","InChI=1S/C55H54ClN7O9/c1-34-38(14-8-15-41(34)37-12-3-2-4-13-37)33-72-48-29-47(71-32-36-11-7-10-35(26-36)30-57)39(27-44(48)56)31-62-25-6-5-16-45(62)52(67)59-24-23-58-49(64)17-9-18-50(65)60-40-19-20-42-43(28-40)55(70)63(54(42)69)46-21-22-51(66)61-53(46)68/h2-4,7-8,10-15,19-20,26-29,45-46H,5-6,9,16-18,21-25,31-33H2,1H3,(H,58,64)(H,59,67)(H,60,65)(H,61,66,68)","YCKLBSIGHUDTTG-UHFFFAOYSA-N"
"1253","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)N3CCN(C(=O)CCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","26.1","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000/>10000","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1018.568","1017.38280405","6.56","74","9","11","2","16","198.76","C57H56ClN7O9","InChI=1S/C57H56ClN7O9/c1-36-40(15-8-16-42(36)39-13-3-2-4-14-39)35-74-49-31-48(73-34-38-12-7-11-37(29-38)32-59)41(30-44(49)58)33-64-24-6-5-19-47(64)56(71)63-27-25-62(26-28-63)52(68)21-10-20-50(66)60-45-18-9-17-43-53(45)57(72)65(55(43)70)46-22-23-51(67)61-54(46)69/h2-4,7-9,11-18,29-31,46-47H,5-6,10,19-28,33-35H2,1H3,(H,60,66)(H,61,67,69)","PRPSPZGKZARAFU-UHFFFAOYSA-N"
"1254","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)N3CCN(C(=O)CCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","44.5","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000/9700","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1004.541","1003.36715399","6.2","73","9","11","2","15","198.76","C56H54ClN7O9","InChI=1S/C56H54ClN7O9/c1-35-39(14-8-15-41(35)38-12-3-2-4-13-38)34-73-48-30-47(72-33-37-11-7-10-36(28-37)31-58)40(29-43(48)57)32-63-23-6-5-18-46(63)55(70)62-26-24-61(25-27-62)51(67)22-21-49(65)59-44-17-9-16-42-52(44)56(71)64(54(42)69)45-19-20-50(66)60-53(45)68/h2-4,7-17,28-30,45-46H,5-6,18-27,32-34H2,1H3,(H,59,65)(H,60,66,68)","KATNSYBIFNRRCF-UHFFFAOYSA-N"
"1255","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","117.6","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","879.414","878.319475524","7.69","64","8","10","3","15","170.17","C50H47ClN6O7","InChI=1S/C50H47ClN6O7/c1-31-35(14-8-15-37(31)34-12-3-2-4-13-34)30-64-44-26-43(63-29-33-11-7-10-32(24-33)27-52)36(25-39(44)51)28-56-23-6-5-18-41(56)47(59)54-22-21-53-40-17-9-16-38-46(40)50(62)57(49(38)61)42-19-20-45(58)55-48(42)60/h2-4,7-17,24-26,41-42,53H,5-6,18-23,28-30H2,1H3,(H,54,59)(H,55,58,60)","ZBBYDEFLHUSCHV-UHFFFAOYSA-N"
"1256","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","97.3","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","893.441","892.335125588","8.04","65","8","10","3","16","170.17","C51H49ClN6O7","InChI=1S/C51H49ClN6O7/c1-32-36(15-8-16-38(32)35-13-3-2-4-14-35)31-65-45-27-44(64-30-34-12-7-11-33(25-34)28-53)37(26-40(45)52)29-57-24-6-5-19-42(57)48(60)55-23-10-22-54-41-18-9-17-39-47(41)51(63)58(50(39)62)43-20-21-46(59)56-49(43)61/h2-4,7-9,11-18,25-27,42-43,54H,5-6,10,19-24,29-31H2,1H3,(H,55,60)(H,56,59,61)","ZVOUAGAHQPRZQW-UHFFFAOYSA-N"
"1257","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","52.8","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8200/>10000/10500","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","907.468","906.350775652","8.4","66","8","10","3","17","170.17","C52H51ClN6O7","InChI=1S/C52H51ClN6O7/c1-33-37(16-10-17-39(33)36-14-3-2-4-15-36)32-66-46-28-45(65-31-35-13-9-12-34(26-35)29-54)38(27-41(46)53)30-58-25-8-5-20-43(58)49(61)56-24-7-6-23-55-42-19-11-18-40-48(42)52(64)59(51(40)63)44-21-22-47(60)57-50(44)62/h2-4,9-19,26-28,43-44,55H,5-8,20-25,30-32H2,1H3,(H,56,61)(H,57,60,62)","IGUOGNZQKFFAQJ-UHFFFAOYSA-N"
"1258","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","170.9","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","921.495","920.366425716","8.76","67","8","10","3","18","170.17","C53H53ClN6O7","InChI=1S/C53H53ClN6O7/c1-34-38(17-11-18-40(34)37-15-4-2-5-16-37)33-67-47-29-46(66-32-36-14-10-13-35(27-36)30-55)39(28-42(47)54)31-59-26-9-6-21-44(59)50(62)57-25-8-3-7-24-56-43-20-12-19-41-49(43)53(65)60(52(41)64)45-22-23-48(61)58-51(45)63/h2,4-5,10-20,27-29,44-45,56H,3,6-9,21-26,31-33H2,1H3,(H,57,62)(H,58,61,63)","LQCPCJZOJVAXGI-UHFFFAOYSA-N"
"1259","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","935.522","934.38207578","9.11","68","8","10","3","19","170.17","C54H55ClN6O7","InChI=1S/C54H55ClN6O7/c1-35-39(18-12-19-41(35)38-16-5-4-6-17-38)34-68-48-30-47(67-33-37-15-11-14-36(28-37)31-56)40(29-43(48)55)32-60-27-10-7-22-45(60)51(63)58-26-9-3-2-8-25-57-44-21-13-20-42-50(44)54(66)61(53(42)65)46-23-24-49(62)59-52(46)64/h4-6,11-21,28-30,45-46,57H,2-3,7-10,22-27,32-34H2,1H3,(H,58,63)(H,59,62,64)","WCPQGPDJSVLANY-UHFFFAOYSA-N"
"1260","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","","98.8","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","978.503","977.351503924","6.06","71","8","11","4","18","216.34","C54H52ClN7O9","InChI=1S/C54H52ClN7O9/c1-33-37(14-8-15-39(33)36-12-3-2-4-13-36)32-71-46-28-45(70-31-35-11-7-10-34(26-35)29-56)38(27-41(46)55)30-61-25-6-5-18-43(61)51(66)58-24-23-57-47(63)21-22-48(64)59-42-17-9-16-40-50(42)54(69)62(53(40)68)44-19-20-49(65)60-52(44)67/h2-4,7-17,26-28,43-44H,5-6,18-25,30-32H2,1H3,(H,57,63)(H,58,66)(H,59,64)(H,60,65,67)","GFUUJGFYXCWGAI-UHFFFAOYSA-N"
"1261","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)COCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=CC=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","994.502","993.346418544","6.11","72","8","12","4","19","225.57","C54H52ClN7O10","InChI=1S/C54H52ClN7O10/c1-33-37(14-8-15-39(33)36-12-3-2-4-13-36)30-72-46-26-45(71-29-35-11-7-10-34(24-35)27-56)38(25-41(46)55)28-61-23-6-5-18-43(61)51(66)58-22-21-57-48(64)31-70-32-49(65)59-42-17-9-16-40-50(42)54(69)62(53(40)68)44-19-20-47(63)60-52(44)67/h2-4,7-17,24-26,43-44H,5-6,18-23,28-32H2,1H3,(H,57,64)(H,58,66)(H,59,65)(H,60,63,67)","IZBUJGWQHWMFAF-UHFFFAOYSA-N"
"1262","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1050.566","1049.37263329","6.13","76","9","13","4","19","234.8","C57H56ClN7O11","InChI=1S/C57H56ClN7O11/c1-34-38(10-5-11-40(34)37-17-19-46-49(28-37)74-25-24-73-46)33-76-48-29-47(75-32-36-9-4-8-35(26-36)30-59)39(27-42(48)58)31-64-23-3-2-14-44(64)54(69)61-22-21-60-50(66)15-7-16-51(67)62-43-13-6-12-41-53(43)57(72)65(56(41)71)45-18-20-52(68)63-55(45)70/h4-6,8-13,17,19,26-29,44-45H,2-3,7,14-16,18,20-25,31-33H2,1H3,(H,60,66)(H,61,69)(H,62,67)(H,63,68,70)","LCRABQSOXRDSSX-UHFFFAOYSA-N"
"1263","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCCC(=O)NC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1050.566","1049.37263329","5.58","76","9","13","4","19","234.8","C57H56ClN7O11","InChI=1S/C57H56ClN7O11/c1-34-38(9-5-10-41(34)37-14-18-47-50(27-37)74-24-23-73-47)33-76-49-29-48(75-32-36-8-4-7-35(25-36)30-59)39(26-44(49)58)31-64-22-3-2-11-45(64)54(69)61-21-20-60-51(66)12-6-13-52(67)62-40-15-16-42-43(28-40)57(72)65(56(42)71)46-17-19-53(68)63-55(46)70/h4-5,7-10,14-16,18,25-29,45-46H,2-3,6,11-13,17,19-24,31-33H2,1H3,(H,60,66)(H,61,69)(H,62,67)(H,63,68,70)","WLLGUIOFCHSFOU-UHFFFAOYSA-N"
"1264","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)COCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1052.538","1051.35189785","5.82","76","9","14","4","19","244.03","C56H54ClN7O12","InChI=1S/C56H54ClN7O12/c1-33-37(9-5-10-39(33)36-14-16-45-48(25-36)74-22-21-73-45)30-76-47-26-46(75-29-35-8-4-7-34(23-35)27-58)38(24-41(47)57)28-63-20-3-2-13-43(63)53(68)60-19-18-59-50(66)31-72-32-51(67)61-42-12-6-11-40-52(42)56(71)64(55(40)70)44-15-17-49(65)62-54(44)69/h4-12,14,16,23-26,43-44H,2-3,13,15,17-22,28-32H2,1H3,(H,59,66)(H,60,68)(H,61,67)(H,62,65,69)","NTLREMVPQSYZOY-UHFFFAOYSA-N"
"1265","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC(=O)CCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1036.539","1035.35698323","5.78","75","9","13","4","18","234.8","C56H54ClN7O11","InChI=1S/C56H54ClN7O11/c1-33-37(9-5-10-39(33)36-14-16-45-48(27-36)73-24-23-72-45)32-75-47-28-46(74-31-35-8-4-7-34(25-35)29-58)38(26-41(47)57)30-63-22-3-2-13-43(63)53(68)60-21-20-59-49(65)18-19-50(66)61-42-12-6-11-40-52(42)56(71)64(55(40)70)44-15-17-51(67)62-54(44)69/h4-12,14,16,25-28,43-44H,2-3,13,15,17-24,30-32H2,1H3,(H,59,65)(H,60,68)(H,61,66)(H,62,67,69)","UZZMLPPVAUHGNZ-UHFFFAOYSA-N"
"1266","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)N3CCN(C(=O)CCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","39.2","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000/>10000","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1076.604","1075.38828336","6.27","78","10","13","2","16","217.22","C59H58ClN7O11","InChI=1S/C59H58ClN7O11/c1-36-40(10-5-11-42(36)39-17-19-48-51(30-39)76-27-26-75-48)35-78-50-31-49(77-34-38-9-4-8-37(28-38)32-61)41(29-44(50)60)33-66-21-3-2-14-47(66)58(73)65-24-22-64(23-25-65)54(70)16-7-15-52(68)62-45-13-6-12-43-55(45)59(74)67(57(43)72)46-18-20-53(69)63-56(46)71/h4-6,8-13,17,19,28-31,46-47H,2-3,7,14-16,18,20-27,33-35H2,1H3,(H,62,68)(H,63,69,71)","CJIXMPCTSMEQPG-UHFFFAOYSA-N"
"1267","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)N3CCN(C(=O)CCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","25.2","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9200/>10000/>10000","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","1062.577","1061.37263329","5.92","77","10","13","2","15","217.22","C58H56ClN7O11","InChI=1S/C58H56ClN7O11/c1-35-39(9-5-10-41(35)38-14-16-47-50(29-38)75-26-25-74-47)34-77-49-30-48(76-33-37-8-4-7-36(27-37)31-60)40(28-43(49)59)32-65-20-3-2-13-46(65)57(72)64-23-21-63(22-24-64)53(69)19-18-51(67)61-44-12-6-11-42-54(44)58(73)66(56(42)71)45-15-17-52(68)62-55(45)70/h4-12,14,16,27-30,45-46H,2-3,13,15,17-26,32-34H2,1H3,(H,61,67)(H,62,68,70)","PLURHKMLHQEKQO-UHFFFAOYSA-N"
"1268","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","143.7","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","937.45","936.324954828","7.4","68","9","12","3","15","188.63","C52H49ClN6O9","InChI=1S/C52H49ClN6O9/c1-31-35(9-5-10-37(31)34-14-16-43-46(25-34)66-22-21-65-43)30-68-45-26-44(67-29-33-8-4-7-32(23-33)27-54)36(24-39(45)53)28-58-20-3-2-13-41(58)49(61)56-19-18-55-40-12-6-11-38-48(40)52(64)59(51(38)63)42-15-17-47(60)57-50(42)62/h4-12,14,16,23-26,41-42,55H,2-3,13,15,17-22,28-30H2,1H3,(H,56,61)(H,57,60,62)","ADOZDDAGMZKREV-UHFFFAOYSA-N"
"1269","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","135.2","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","951.477","950.340604892","7.76","69","9","12","3","16","188.63","C53H51ClN6O9","InChI=1S/C53H51ClN6O9/c1-32-36(10-5-11-38(32)35-15-17-44-47(26-35)67-23-22-66-44)31-69-46-27-45(68-30-34-9-4-8-33(24-34)28-55)37(25-40(46)54)29-59-21-3-2-14-42(59)50(62)57-20-7-19-56-41-13-6-12-39-49(41)53(65)60(52(39)64)43-16-18-48(61)58-51(43)63/h4-6,8-13,15,17,24-27,42-43,56H,2-3,7,14,16,18-23,29-31H2,1H3,(H,57,62)(H,58,61,63)","JVDWTHPBJDWEHM-UHFFFAOYSA-N"
"1270","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","102.7","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000/>10000","Inhibit growth of A549/MDA-MB-231/H1299 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","965.504","964.356254956","8.12","70","9","12","3","17","188.63","C54H53ClN6O9","InChI=1S/C54H53ClN6O9/c1-33-37(11-7-12-39(33)36-16-18-45-48(27-36)68-24-23-67-45)32-70-47-28-46(69-31-35-10-6-9-34(25-35)29-56)38(26-41(47)55)30-60-22-5-2-15-43(60)51(63)58-21-4-3-20-57-42-14-8-13-40-50(42)54(66)61(53(40)65)44-17-19-49(62)59-52(44)64/h6-14,16,18,25-28,43-44,57H,2-5,15,17,19-24,30-32H2,1H3,(H,58,63)(H,59,62,64)","RQVFCCRANBVRKS-UHFFFAOYSA-N"
"1271","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","","193.2","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","979.531","978.37190502","8.47","71","9","12","3","18","188.63","C55H55ClN6O9","InChI=1S/C55H55ClN6O9/c1-34-38(12-8-13-40(34)37-17-19-46-49(28-37)69-25-24-68-46)33-71-48-29-47(70-32-36-11-7-10-35(26-36)30-57)39(27-42(48)56)31-61-23-6-3-16-44(61)52(64)59-22-5-2-4-21-58-43-15-9-14-41-51(43)55(67)62(54(41)66)45-18-20-50(63)60-53(45)65/h7-15,17,19,26-29,44-45,58H,2-6,16,18,20-25,31-33H2,1H3,(H,59,64)(H,60,63,65)","VUPZXNWHDOWXOY-UHFFFAOYSA-N"
"1272","Q9NZQ7","PD-L1","CRBN","","","CC1=C(COC2=CC(OCC3=CC=CC(C#N)=C3)=C(CN3CCCCC3C(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2Cl)C=CC=C1C1=CC=C2OCCOC2=C1","","","","","",">200","IC50 of PD-1/PD-L1 interaction was tested by the HTRF binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112377","993.558","992.387555084","8.83","72","9","12","3","19","188.63","C56H57ClN6O9","InChI=1S/C56H57ClN6O9/c1-35-39(13-9-14-41(35)38-18-20-47-50(29-38)70-26-25-69-47)34-72-49-30-48(71-33-37-12-8-11-36(27-37)31-58)40(28-43(49)57)32-62-24-7-4-17-45(62)53(65)60-23-6-3-2-5-22-59-44-16-10-15-42-52(44)56(68)63(55(42)67)46-19-21-51(64)61-54(46)66/h8-16,18,20,27-30,45-46,59H,2-7,17,19,21-26,32-34H2,1H3,(H,60,65)(H,61,64,66)","DZYHLBQKUNTNSV-UHFFFAOYSA-N"
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"1278","Q07817","BCL-xL","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1959","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1554.401","1552.58343561","13.85","106","11","18","4","30","240.07","C78H96ClF3N10O10S4","InChI=1S/C78H96ClF3N10O10S4/c1-53(83-4)73(95)86-71(55-15-7-5-8-16-55)76(97)92-36-14-21-68(92)75-85-67(52-104-75)72(94)57-17-13-18-62(47-57)102-46-12-11-22-70(93)91-44-38-88(39-45-91)37-34-60(51-103-63-19-9-6-10-20-63)84-66-32-31-64(48-69(66)105(98,99)78(80,81)82)106(100,101)87-74(96)56-25-29-61(30-26-56)90-42-40-89(41-43-90)50-58-49-77(2,3)35-33-65(58)54-23-27-59(79)28-24-54/h6,9-10,13,17-20,23-32,47-48,52-53,55,60,68,71,83-84H,5,7-8,11-12,14-16,21-22,33-46,49-51H2,1-4H3,(H,86,95)(H,87,96)/t53-,60+,68-,71-/m0/s1","QHCPQQHKYXICND-RYMMRGPKSA-N"
"1279","Q07817","BCL-xL","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1568.428","1566.59908568","14.21","107","11","18","4","31","240.07","C79H98ClF3N10O10S4","InChI=1S/C79H98ClF3N10O10S4/c1-54(84-4)74(96)87-72(56-16-8-5-9-17-56)77(98)93-37-15-22-69(93)76-86-68(53-105-76)73(95)58-18-14-19-63(48-58)103-47-13-7-12-23-71(94)92-45-39-89(40-46-92)38-35-61(52-104-64-20-10-6-11-21-64)85-67-33-32-65(49-70(67)106(99,100)79(81,82)83)107(101,102)88-75(97)57-26-30-62(31-27-57)91-43-41-90(42-44-91)51-59-50-78(2,3)36-34-66(59)55-24-28-60(80)29-25-55/h6,10-11,14,18-21,24-33,48-49,53-54,56,61,69,72,84-85H,5,7-9,12-13,15-17,22-23,34-47,50-52H2,1-4H3,(H,87,96)(H,88,97)/t54-,61+,69-,72-/m0/s1","WNAVTZLZKVJXLN-FUIOHLFTSA-N"
"1280","Q07817","BCL-xL","cIAP1","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCCCCCC(=O)N3CCN(CC[C@H](CSC4=CC=CC=C4)NC4=CC=C(S(=O)(=O)NC(=O)C5=CC=C(N6CCN(CC7=C(C8=CC=C(Cl)C=C8)CCC(C)(C)C7)CC6)C=C5)C=C4S(=O)(=O)C(F)(F)F)CC3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1582.455","1580.61473574","14.75","108","11","18","4","32","240.07","C80H100ClF3N10O10S4","InChI=1S/C80H100ClF3N10O10S4/c1-55(85-4)75(97)88-73(57-17-9-7-10-18-57)78(99)94-38-16-23-70(94)77-87-69(54-106-77)74(96)59-19-15-20-64(49-59)104-48-14-6-5-13-24-72(95)93-46-40-90(41-47-93)39-36-62(53-105-65-21-11-8-12-22-65)86-68-34-33-66(50-71(68)107(100,101)80(82,83)84)108(102,103)89-76(98)58-27-31-63(32-28-58)92-44-42-91(43-45-92)52-60-51-79(2,3)37-35-67(60)56-25-29-61(81)30-26-56/h8,11-12,15,19-22,25-34,49-50,54-55,57,62,70,73,85-86H,5-7,9-10,13-14,16-18,23-24,35-48,51-53H2,1-4H3,(H,88,97)(H,89,98)/t55-,62+,70-,73-/m0/s1","VNCDCUWAAVDYLQ-XPBVACSYSA-N"
"1281","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCOCCOCC5=CN(CCCC(=O)N6CCN(CC[C@H](CSC7=CC=CC=C7)NC7=CC=C(S(=O)(=O)NC(=O)C8=CC=C(N9CCN(CC%10=C(C%11=CC=C(Cl)C=C%11)CCC(C)(C)C%10)CC9)C=C8)C=C7S(=O)(=O)C(F)(F)F)CC6)N=N5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","153","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1683.495","1681.69140582","10.42","116","12","22","5","34","297.61","C83H107ClF3N13O13S3","InChI=1S/C83H107ClF3N13O13S3/c1-56(88-6)77(102)91-72-31-43-113-75-51-82(4,5)76(100(75)80(72)105)79(104)90-70-15-10-12-59-48-65(25-27-69(59)70)112-47-46-110-44-45-111-54-63-53-99(94-92-63)33-11-16-74(101)98-41-35-95(36-42-98)34-30-62(55-114-66-13-8-7-9-14-66)89-71-28-26-67(49-73(71)115(106,107)83(85,86)87)116(108,109)93-78(103)58-19-23-64(24-20-58)97-39-37-96(38-40-97)52-60-50-81(2,3)32-29-68(60)57-17-21-61(84)22-18-57/h7-9,13-14,17-28,48-49,53,56,62,70,72,75-76,88-89H,10-12,15-16,29-47,50-52,54-55H2,1-6H3,(H,90,104)(H,91,102)(H,93,103)/t56-,62+,70+,72-,75-,76+/m0/s1","UPBIPOXDWGANOD-HTZTZTFKSA-N"
"1282","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCOCCOCCOCC5=CN(CCCC(=O)N6CCN(CC[C@H](CSC7=CC=CC=C7)NC7=CC=C(S(=O)(=O)NC(=O)C8=CC=C(N9CCN(CC%10=C(C%11=CC=C(Cl)C=C%11)CCC(C)(C)C%10)CC9)C=C8)C=C7S(=O)(=O)C(F)(F)F)CC6)N=N5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","119","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1727.548","1725.71762057","10.28","119","12","23","5","37","306.84","C85H111ClF3N13O14S3","InChI=1S/C85H111ClF3N13O14S3/c1-58(90-6)79(104)93-74-31-43-116-77-53-84(4,5)78(102(77)82(74)107)81(106)92-72-15-10-12-61-50-67(25-27-71(61)72)115-49-48-113-45-44-112-46-47-114-56-65-55-101(96-94-65)33-11-16-76(103)100-41-35-97(36-42-100)34-30-64(57-117-68-13-8-7-9-14-68)91-73-28-26-69(51-75(73)118(108,109)85(87,88)89)119(110,111)95-80(105)60-19-23-66(24-20-60)99-39-37-98(38-40-99)54-62-52-83(2,3)32-29-70(62)59-17-21-63(86)22-18-59/h7-9,13-14,17-28,50-51,55,58,64,72,74,77-78,90-91H,10-12,15-16,29-49,52-54,56-57H2,1-6H3,(H,92,106)(H,93,104)(H,95,105)/t58-,64+,72+,74-,77-,78+/m0/s1","IJLRIBMZFPNAQW-MJURQWTQSA-N"
"1283","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCOCCOCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","100","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1574.363","1572.6274086","10.93","108","11","19","5","30","266.9","C78H100ClF3N10O13S3","InChI=1S/C78H100ClF3N10O13S3/c1-52(83-6)72(94)86-67-29-40-105-70-48-77(4,5)71(92(70)75(67)97)74(96)85-65-14-10-11-55-45-60(23-25-64(55)65)104-44-43-102-41-42-103-50-69(93)91-38-32-88(33-39-91)31-28-58(51-106-61-12-8-7-9-13-61)84-66-26-24-62(46-68(66)107(98,99)78(80,81)82)108(100,101)87-73(95)54-17-21-59(22-18-54)90-36-34-89(35-37-90)49-56-47-76(2,3)30-27-63(56)53-15-19-57(79)20-16-53/h7-9,12-13,15-26,45-46,52,58,65,67,70-71,83-84H,10-11,14,27-44,47-51H2,1-6H3,(H,85,96)(H,86,94)(H,87,95)/t52-,58+,65+,67-,70-,71+/m0/s1","BRJDFKWZINUDBT-WRSXDRJZSA-N"
"1284","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCOCCOCCOCCOCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","70","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1662.469","1660.6798381","10.64","114","11","21","5","36","285.36","C82H108ClF3N10O15S3","InChI=1S/C82H108ClF3N10O15S3/c1-56(87-6)76(98)90-71-29-40-111-74-52-81(4,5)75(96(74)79(71)101)78(100)89-69-14-10-11-59-49-64(23-25-68(59)69)110-48-47-108-44-43-106-41-42-107-45-46-109-54-73(97)95-38-32-92(33-39-95)31-28-62(55-112-65-12-8-7-9-13-65)88-70-26-24-66(50-72(70)113(102,103)82(84,85)86)114(104,105)91-77(99)58-17-21-63(22-18-58)94-36-34-93(35-37-94)53-60-51-80(2,3)30-27-67(60)57-15-19-61(83)20-16-57/h7-9,12-13,15-26,49-50,56,62,69,71,74-75,87-88H,10-11,14,27-48,51-55H2,1-6H3,(H,89,100)(H,90,98)(H,91,99)/t56-,62+,69+,71-,74-,75+/m0/s1","VVWLLVZOEYUPFB-GRHHIWKCSA-N"
"1285","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","62","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1514.311","1512.60627923","11.49","104","11","17","5","26","248.44","C76H96ClF3N10O11S3","InChI=1S/C76H96ClF3N10O11S3/c1-50(81-6)70(92)84-65-31-43-101-68-47-75(4,5)69(90(68)73(65)95)72(94)83-63-15-10-12-53-44-58(25-27-62(53)63)100-42-11-16-67(91)89-40-34-86(35-41-89)33-30-56(49-102-59-13-8-7-9-14-59)82-64-28-26-60(45-66(64)103(96,97)76(78,79)80)104(98,99)85-71(93)52-19-23-57(24-20-52)88-38-36-87(37-39-88)48-54-46-74(2,3)32-29-61(54)51-17-21-55(77)22-18-51/h7-9,13-14,17-28,44-45,50,56,63,65,68-69,81-82H,10-12,15-16,29-43,46-49H2,1-6H3,(H,83,94)(H,84,92)(H,85,93)/t50-,56+,63+,65-,68-,69+/m0/s1","HHMCHRRZMCHLLA-PYINPHMPSA-N"
"1286","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCCCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","76","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1528.338","1526.6219293","11.85","105","11","17","5","27","248.44","C77H98ClF3N10O11S3","InChI=1S/C77H98ClF3N10O11S3/c1-51(82-6)71(93)85-66-32-44-102-69-48-76(4,5)70(91(69)74(66)96)73(95)84-64-16-12-13-54-45-59(26-28-63(54)64)101-43-11-10-17-68(92)90-41-35-87(36-42-90)34-31-57(50-103-60-14-8-7-9-15-60)83-65-29-27-61(46-67(65)104(97,98)77(79,80)81)105(99,100)86-72(94)53-20-24-58(25-21-53)89-39-37-88(38-40-89)49-55-47-75(2,3)33-30-62(55)52-18-22-56(78)23-19-52/h7-9,14-15,18-29,45-46,51,57,64,66,69-70,82-83H,10-13,16-17,30-44,47-50H2,1-6H3,(H,84,95)(H,85,93)(H,86,94)/t51-,57+,64+,66-,69-,70+/m0/s1","RMLTUDISHNCFGE-GOENFTANSA-N"
"1287","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCCCCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","127","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1542.365","1540.63757936","12.2","106","11","17","5","28","248.44","C78H100ClF3N10O11S3","InChI=1S/C78H100ClF3N10O11S3/c1-52(83-6)72(94)86-67-33-45-103-70-49-77(4,5)71(92(70)75(67)97)74(96)85-65-17-13-14-55-46-60(27-29-64(55)65)102-44-12-8-11-18-69(93)91-42-36-88(37-43-91)35-32-58(51-104-61-15-9-7-10-16-61)84-66-30-28-62(47-68(66)105(98,99)78(80,81)82)106(100,101)87-73(95)54-21-25-59(26-22-54)90-40-38-89(39-41-90)50-56-48-76(2,3)34-31-63(56)53-19-23-57(79)24-20-53/h7,9-10,15-16,19-30,46-47,52,58,65,67,70-71,83-84H,8,11-14,17-18,31-45,48-51H2,1-6H3,(H,85,96)(H,86,94)(H,87,95)/t52-,58+,65+,67-,70-,71+/m0/s1","HHEYBRDGLDWZDW-WRSXDRJZSA-N"
"1288","Q07817","BCL-xL","XIAP","","","CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@@H](C(=O)N[C@@H]3CCCC4=CC(OCCCCCCC(=O)N5CCN(CC[C@H](CSC6=CC=CC=C6)NC6=CC=C(S(=O)(=O)NC(=O)C7=CC=C(N8CCN(CC9=C(C%10=CC=C(Cl)C=C%10)CCC(C)(C)C9)CC8)C=C7)C=C6S(=O)(=O)C(F)(F)F)CC5)=CC=C43)N2C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","274","Inhibit viability of MyLa 1929 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112397","1556.392","1554.65322942","12.74","107","11","17","5","29","248.44","C79H102ClF3N10O11S3","InChI=1S/C79H102ClF3N10O11S3/c1-53(84-6)73(95)87-68-34-46-104-71-50-78(4,5)72(93(71)76(68)98)75(97)86-66-18-14-15-56-47-61(28-30-65(56)66)103-45-13-8-7-12-19-70(94)92-43-37-89(38-44-92)36-33-59(52-105-62-16-10-9-11-17-62)85-67-31-29-63(48-69(67)106(99,100)79(81,82)83)107(101,102)88-74(96)55-22-26-60(27-23-55)91-41-39-90(40-42-91)51-57-49-77(2,3)35-32-64(57)54-20-24-58(80)25-21-54/h9-11,16-17,20-31,47-48,53,59,66,68,71-72,84-85H,7-8,12-15,18-19,32-46,49-52H2,1-6H3,(H,86,97)(H,87,95)(H,88,96)/t53-,59+,66+,68-,71-,72+/m0/s1","CZTVZHQDBWIVOB-LRBLUWHQSA-N"
"1289","P09874","PARP1","CRBN","","iRucaparib-TP1","CN(CCCCC1=CN(CCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)CC1=CC=C(C2=C3CCNC(=O)C4=C3C(=CC(F)=C4)[NH]2)C=C1","","N.D.","","","","13.4","IC50 was tested by using a PARP universal chemiluminescent assay kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","789.869","789.339858348","3.65","58","8","11","4","16","183.65","C42H44FN9O6","InChI=1S/C42H44FN9O6/c1-50(23-25-8-10-26(11-9-25)38-29-14-15-45-39(54)31-21-27(43)22-33(46-38)36(29)31)17-3-2-5-28-24-51(49-48-28)18-20-58-19-16-44-32-7-4-6-30-37(32)42(57)52(41(30)56)34-12-13-35(53)47-40(34)55/h4,6-11,21-22,24,34,44,46H,2-3,5,12-20,23H2,1H3,(H,45,54)(H,47,53,55)","AZBXJGJVABZWSA-UHFFFAOYSA-N"
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"1291","P09874","PARP1","CRBN","","iRucaparib-TP3","CN(CCCCC1=CN(CCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)CC1=CC=C(C2=C3CCNC(=O)C4=C3C(=CC(F)=C4)[NH]2)C=C1","","","","","","18.3","IC50 was tested by using a PARP universal chemiluminescent assay kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","877.975","877.392287844","3.36","64","8","13","4","22","202.11","C46H52FN9O8","InChI=1S/C46H52FN9O8/c1-54(27-29-8-10-30(11-9-29)42-33-14-15-49-43(58)35-25-31(47)26-37(50-42)40(33)35)17-3-2-5-32-28-55(53-52-32)18-20-63-22-24-64-23-21-62-19-16-48-36-7-4-6-34-41(36)46(61)56(45(34)60)38-12-13-39(57)51-44(38)59/h4,6-11,25-26,28,38,48,50H,2-3,5,12-24,27H2,1H3,(H,49,58)(H,51,57,59)","WOCUITLZAXIDDD-UHFFFAOYSA-N"
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"1299","Q9Y6F1","PARP3","CRBN","","iRucaparib-AP5","CN(CCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1=CC=C(C2=C3CCNC(=O)C4=C3C(=CC(F)=C4)[NH]2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","842.922","842.365070052","2.66","61","7","12","4","23","189.86","C44H51FN6O10","InChI=1S/C44H51FN6O10/c1-50(27-28-5-7-29(8-6-28)40-31-11-12-47-41(53)33-25-30(45)26-35(48-40)38(31)33)14-16-58-18-20-60-22-24-61-23-21-59-19-17-57-15-13-46-34-4-2-3-32-39(34)44(56)51(43(32)55)36-9-10-37(52)49-42(36)54/h2-8,25-26,36,46,48H,9-24,27H2,1H3,(H,47,53)(H,49,52,54)","CDKSZVJXSCKNQN-UHFFFAOYSA-N"
"1299","P09874","PARP1","CRBN","","iRucaparib-AP5","CN(CCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1=CC=C(C2=C3CCNC(=O)C4=C3C(=CC(F)=C4)[NH]2)C=C1","35.7","90","Degradation of PARP1 in Primary Cardiomyocytes after 24 h treatment","","","24.6","IC50 was tested by using a PARP universal chemiluminescent assay kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","842.922","842.365070052","2.66","61","7","12","4","23","189.86","C44H51FN6O10","InChI=1S/C44H51FN6O10/c1-50(27-28-5-7-29(8-6-28)40-31-11-12-47-41(53)33-25-30(45)26-35(48-40)38(31)33)14-16-58-18-20-60-22-24-61-23-21-59-19-17-57-15-13-46-34-4-2-3-32-39(34)44(56)51(43(32)55)36-9-10-37(52)49-42(36)54/h2-8,25-26,36,46,48H,9-24,27H2,1H3,(H,47,53)(H,49,52,54)","CDKSZVJXSCKNQN-UHFFFAOYSA-N"
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"1300","P09874","PARP1","CRBN","","iRucaparib-AP6","CN(CCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1=CC=C(C2=C3CCNC(=O)C4=C3C(=CC(F)=C4)[NH]2)C=C1","81.8","92","Degradation of PARP1 in Primary Cardiomyocytes after 24 h treatment","","","28.5","IC50 was tested by using a PARP universal chemiluminescent assay kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","886.975","886.3912848","2.51","64","7","13","4","26","199.09","C46H55FN6O11","InChI=1S/C46H55FN6O11/c1-52(29-30-5-7-31(8-6-30)42-33-11-12-49-43(55)35-27-32(47)28-37(50-42)40(33)35)14-16-60-18-20-62-22-24-64-26-25-63-23-21-61-19-17-59-15-13-48-36-4-2-3-34-41(36)46(58)53(45(34)57)38-9-10-39(54)51-44(38)56/h2-8,27-28,38,48,50H,9-26,29H2,1H3,(H,49,55)(H,51,54,56)","YHMDCINUVWULST-UHFFFAOYSA-N"
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"1306","Q9UGN5","PARP2","CRBN","","iVeliparib-AP6","C[C@]1(C2=NC3=C(C(N)=O)C=CC=C3[NH]2)CCCN1CCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","62.8","","Degradation of PARP2 in HeLa cells after 24 h treatment","","","21.1","IC50 was tested by using a PARP2 chemiluminescent assay kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0379-2","807.902","807.380305516","0.5","58","6","14","4","25","225.97","C40H53N7O11","InChI=1S/C40H53N7O11/c1-40(39-43-30-8-3-6-28(35(41)49)34(30)45-39)11-4-13-46(40)14-16-54-18-20-56-22-24-58-26-25-57-23-21-55-19-17-53-15-12-42-29-7-2-5-27-33(29)38(52)47(37(27)51)31-9-10-32(48)44-36(31)50/h2-3,5-8,31,42H,4,9-26H2,1H3,(H2,41,49)(H,43,45)(H,44,48,50)/t31?,40-/m1/s1","XLGCZZCLPNSQNH-YMURELKOSA-N"
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"1328","Q9UBN7","HDAC6","CRBN","","YZ273","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCN2C=C(CNCC3=CC=C(C4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.008","855.997","855.406795036","3.86","63","7","11","5","20","200.12","C47H53N9O7","InChI=1S/C47H53N9O7/c1-2-3-24-54(29-33-12-16-35(17-13-33)44(58)52-62)47(61)49-36-18-20-38(21-19-36)63-26-6-4-5-25-55-30-37(51-53-55)28-48-27-32-10-14-34(15-11-32)39-8-7-9-40-41(39)31-56(46(40)60)42-22-23-43(57)50-45(42)59/h7-21,30,42,48,62H,2-6,22-29,31H2,1H3,(H,49,61)(H,52,58)(H,50,57,59)","RGPCCNVVKKJDCC-UHFFFAOYSA-N"
"1329","Q9UBN7","HDAC6","CRBN","","WH641","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCCN2C=C(CNCC3=CC=C(C4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.008","870.024","869.4224451","4.22","64","7","11","5","21","200.12","C48H55N9O7","InChI=1S/C48H55N9O7/c1-2-3-25-55(30-34-13-17-36(18-14-34)45(59)53-63)48(62)50-37-19-21-39(22-20-37)64-27-7-5-4-6-26-56-31-38(52-54-56)29-49-28-33-11-15-35(16-12-33)40-9-8-10-41-42(40)32-57(47(41)61)43-23-24-44(58)51-46(43)60/h8-22,31,43,49,63H,2-7,23-30,32H2,1H3,(H,50,62)(H,53,59)(H,51,58,60)","HKQNNPXJPQOBPR-UHFFFAOYSA-N"
"1330","Q9UBN7","HDAC6","CRBN","","YZ268","CCCCN(CC1=CC=C(C(=O)NO)C=C1)C(=O)NC1=CC=C(OCCCCCCCN2C=C(CNCC3=CC=C(C4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N=N2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.04.008","884.051","883.438095164","4.76","65","7","11","5","22","200.12","C49H57N9O7","InChI=1S/C49H57N9O7/c1-2-3-26-56(31-35-14-18-37(19-15-35)46(60)54-64)49(63)51-38-20-22-40(23-21-38)65-28-8-6-4-5-7-27-57-32-39(53-55-57)30-50-29-34-12-16-36(17-13-34)41-10-9-11-42-43(41)33-58(48(42)62)44-24-25-45(59)52-47(44)61/h9-23,32,44,50,64H,2-8,24-31,33H2,1H3,(H,51,63)(H,54,60)(H,52,59,61)","WFLGLHJDVMTEJN-UHFFFAOYSA-N"
"1331","","Alpha-tubulin","CRBN","","BJG-02-098","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","341.7","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1193.491","1192.69951437","4.39","85","5","17","5","37","273.25","C62H96N8O15","InChI=1S/C62H96N8O15/c1-13-40(6)54(48(80-11)37-50(72)69-27-18-23-46(69)56(81-12)41(7)57(74)64-42(8)55(73)43-19-15-14-16-20-43)68(10)62(79)52(38(2)3)66-59(76)53(39(4)5)67(9)28-30-83-32-34-85-36-35-84-33-31-82-29-26-63-45-22-17-21-44-51(45)61(78)70(60(44)77)47-24-25-49(71)65-58(47)75/h14-17,19-22,38-42,46-48,52-56,63,73H,13,18,23-37H2,1-12H3,(H,64,74)(H,66,76)(H,65,71,75)/t40-,41+,42+,46-,47?,48+,52-,53-,54-,55+,56+/m0/s1","SNRKZQWVOKOHTM-UMJCIVAUSA-N"
"1331","P07437","Beta-tubulin","CRBN","","BJG-02-098","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","341.7","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1193.491","1192.69951437","4.39","85","5","17","5","37","273.25","C62H96N8O15","InChI=1S/C62H96N8O15/c1-13-40(6)54(48(80-11)37-50(72)69-27-18-23-46(69)56(81-12)41(7)57(74)64-42(8)55(73)43-19-15-14-16-20-43)68(10)62(79)52(38(2)3)66-59(76)53(39(4)5)67(9)28-30-83-32-34-85-36-35-84-33-31-82-29-26-63-45-22-17-21-44-51(45)61(78)70(60(44)77)47-24-25-49(71)65-58(47)75/h14-17,19-22,38-42,46-48,52-56,63,73H,13,18,23-37H2,1-12H3,(H,64,74)(H,66,76)(H,65,71,75)/t40-,41+,42+,46-,47?,48+,52-,53-,54-,55+,56+/m0/s1","SNRKZQWVOKOHTM-UMJCIVAUSA-N"
"1332","","Alpha-tubulin","CRBN","","BJG-02-108","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","Inactive","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1157.549","1156.75115602","9.66","83","5","13","5","35","236.33","C64H100N8O11","InChI=1S/C64H100N8O11/c1-13-42(6)56(50(82-11)39-52(74)71-38-28-33-48(71)58(83-12)43(7)59(76)66-44(8)57(75)45-29-23-22-24-30-45)70(10)64(81)54(40(2)3)68-61(78)55(41(4)5)69(9)37-26-21-19-17-15-14-16-18-20-25-36-65-47-32-27-31-46-53(47)63(80)72(62(46)79)49-34-35-51(73)67-60(49)77/h22-24,27,29-32,40-44,48-50,54-58,65,75H,13-21,25-26,28,33-39H2,1-12H3,(H,66,76)(H,68,78)(H,67,73,77)/t42-,43+,44+,48-,49?,50+,54-,55-,56-,57+,58+/m0/s1","VCAXDAHGPHVHRX-BAPZVFFDSA-N"
"1332","P07437","Beta-tubulin","CRBN","","BJG-02-108","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","Inactive","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1157.549","1156.75115602","9.66","83","5","13","5","35","236.33","C64H100N8O11","InChI=1S/C64H100N8O11/c1-13-42(6)56(50(82-11)39-52(74)71-38-28-33-48(71)58(83-12)43(7)59(76)66-44(8)57(75)45-29-23-22-24-30-45)70(10)64(81)54(40(2)3)68-61(78)55(41(4)5)69(9)37-26-21-19-17-15-14-16-18-20-25-36-65-47-32-27-31-46-53(47)63(80)72(62(46)79)49-34-35-51(73)67-60(49)77/h22-24,27,29-32,40-44,48-50,54-58,65,75H,13-21,25-26,28,33-39H2,1-12H3,(H,66,76)(H,68,78)(H,67,73,77)/t42-,43+,44+,48-,49?,50+,54-,55-,56-,57+,58+/m0/s1","VCAXDAHGPHVHRX-BAPZVFFDSA-N"
"1333","","Alpha-tubulin","CRBN","","BJG-02-095","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","10000","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1171.532","1170.73042058","8.69","84","5","13","5","34","253.4","C64H98N8O12","InChI=1S/C64H98N8O12/c1-13-41(6)56(49(83-11)38-52(75)71-37-27-32-47(71)58(84-12)42(7)59(77)66-43(8)57(76)44-28-22-21-23-29-44)70(10)64(82)54(39(2)3)68-61(79)55(40(4)5)69(9)51(74)33-24-19-17-15-14-16-18-20-25-36-65-46-31-26-30-45-53(46)63(81)72(62(45)80)48-34-35-50(73)67-60(48)78/h21-23,26,28-31,39-43,47-49,54-58,65,76H,13-20,24-25,27,32-38H2,1-12H3,(H,66,77)(H,68,79)(H,67,73,78)/t41-,42+,43+,47-,48?,49+,54-,55-,56-,57+,58+/m0/s1","OXTCTKVCXZYWPJ-BYOFMMMDSA-N"
"1333","P07437","Beta-tubulin","CRBN","","BJG-02-095","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","10000","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1171.532","1170.73042058","8.69","84","5","13","5","34","253.4","C64H98N8O12","InChI=1S/C64H98N8O12/c1-13-41(6)56(49(83-11)38-52(75)71-37-27-32-47(71)58(84-12)42(7)59(77)66-43(8)57(76)44-28-22-21-23-29-44)70(10)64(82)54(39(2)3)68-61(79)55(40(4)5)69(9)51(74)33-24-19-17-15-14-16-18-20-25-36-65-46-31-26-30-45-53(46)63(81)72(62(45)80)48-34-35-50(73)67-60(48)78/h21-23,26,28-31,39-43,47-49,54-58,65,76H,13-20,24-25,27,32-38H2,1-12H3,(H,66,77)(H,68,79)(H,67,73,78)/t41-,42+,43+,47-,48?,49+,54-,55-,56-,57+,58+/m0/s1","OXTCTKVCXZYWPJ-BYOFMMMDSA-N"
"1334","","Alpha-tubulin","CRBN","","BJG-03-088","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","72.8","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1105.385","1104.64708488","4.68","79","5","15","5","31","254.79","C58H88N8O13","InChI=1S/C58H88N8O13/c1-13-36(6)50(44(76-11)33-46(68)65-27-18-23-42(65)52(77-12)37(7)53(70)60-38(8)51(69)39-19-15-14-16-20-39)64(10)58(75)48(34(2)3)62-55(72)49(35(4)5)63(9)28-30-79-32-31-78-29-26-59-41-22-17-21-40-47(41)57(74)66(56(40)73)43-24-25-45(67)61-54(43)71/h14-17,19-22,34-38,42-44,48-52,59,69H,13,18,23-33H2,1-12H3,(H,60,70)(H,62,72)(H,61,67,71)/t36-,37+,38+,42-,43?,44+,48-,49-,50-,51+,52+/m0/s1","JVINRIYOSSAGQQ-KEAWISHESA-N"
"1334","P07437","Beta-tubulin","CRBN","","BJG-03-088","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","72.8","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1105.385","1104.64708488","4.68","79","5","15","5","31","254.79","C58H88N8O13","InChI=1S/C58H88N8O13/c1-13-36(6)50(44(76-11)33-46(68)65-27-18-23-42(65)52(77-12)37(7)53(70)60-38(8)51(69)39-19-15-14-16-20-39)64(10)58(75)48(34(2)3)62-55(72)49(35(4)5)63(9)28-30-79-32-31-78-29-26-59-41-22-17-21-40-47(41)57(74)66(56(40)73)43-24-25-45(67)61-54(43)71/h14-17,19-22,34-38,42-44,48-52,59,69H,13,18,23-33H2,1-12H3,(H,60,70)(H,62,72)(H,61,67,71)/t36-,37+,38+,42-,43?,44+,48-,49-,50-,51+,52+/m0/s1","JVINRIYOSSAGQQ-KEAWISHESA-N"
"1335","","Alpha-tubulin","CRBN","","BJG-02-160","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","466.7","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1149.438","1148.67329962","4.53","82","5","16","5","34","264.02","C60H92N8O14","InChI=1S/C60H92N8O14/c1-13-38(6)52(46(78-11)35-48(70)67-27-18-23-44(67)54(79-12)39(7)55(72)62-40(8)53(71)41-19-15-14-16-20-41)66(10)60(77)50(36(2)3)64-57(74)51(37(4)5)65(9)28-30-81-32-34-82-33-31-80-29-26-61-43-22-17-21-42-49(43)59(76)68(58(42)75)45-24-25-47(69)63-56(45)73/h14-17,19-22,36-40,44-46,50-54,61,71H,13,18,23-35H2,1-12H3,(H,62,72)(H,64,74)(H,63,69,73)/t38-,39+,40+,44-,45?,46+,50-,51-,52-,53+,54+/m0/s1","QRLWEJQTXWHPMO-YTONRHDRSA-N"
"1335","P07437","Beta-tubulin","CRBN","","BJG-02-160","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","466.7","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1149.438","1148.67329962","4.53","82","5","16","5","34","264.02","C60H92N8O14","InChI=1S/C60H92N8O14/c1-13-38(6)52(46(78-11)35-48(70)67-27-18-23-44(67)54(79-12)39(7)55(72)62-40(8)53(71)41-19-15-14-16-20-41)66(10)60(77)50(36(2)3)64-57(74)51(37(4)5)65(9)28-30-81-32-34-82-33-31-80-29-26-61-43-22-17-21-42-49(43)59(76)68(58(42)75)45-24-25-47(69)63-56(45)73/h14-17,19-22,36-40,44-46,50-54,61,71H,13,18,23-35H2,1-12H3,(H,62,72)(H,64,74)(H,63,69,73)/t38-,39+,40+,44-,45?,46+,50-,51-,52-,53+,54+/m0/s1","QRLWEJQTXWHPMO-YTONRHDRSA-N"
"1336","","Alpha-tubulin","CRBN","","BJG-02-164","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","440.3","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1237.544","1236.72572912","4.24","88","5","18","5","40","282.48","C64H100N8O16","InChI=1S/C64H100N8O16/c1-13-42(6)56(50(82-11)39-52(74)71-27-18-23-48(71)58(83-12)43(7)59(76)66-44(8)57(75)45-19-15-14-16-20-45)70(10)64(81)54(40(2)3)68-61(78)55(41(4)5)69(9)28-30-85-32-34-87-36-38-88-37-35-86-33-31-84-29-26-65-47-22-17-21-46-53(47)63(80)72(62(46)79)49-24-25-51(73)67-60(49)77/h14-17,19-22,40-44,48-50,54-58,65,75H,13,18,23-39H2,1-12H3,(H,66,76)(H,68,78)(H,67,73,77)/t42-,43+,44+,48-,49?,50+,54-,55-,56-,57+,58+/m0/s1","WWDSYKAVVVERQX-BAPZVFFDSA-N"
"1336","P07437","Beta-tubulin","CRBN","","BJG-02-164","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","440.3","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1237.544","1236.72572912","4.24","88","5","18","5","40","282.48","C64H100N8O16","InChI=1S/C64H100N8O16/c1-13-42(6)56(50(82-11)39-52(74)71-27-18-23-48(71)58(83-12)43(7)59(76)66-44(8)57(75)45-19-15-14-16-20-45)70(10)64(81)54(40(2)3)68-61(78)55(41(4)5)69(9)28-30-85-32-34-87-36-38-88-37-35-86-33-31-84-29-26-65-47-22-17-21-46-53(47)63(80)72(62(46)79)49-24-25-51(73)67-60(49)77/h14-17,19-22,40-44,48-50,54-58,65,75H,13,18,23-39H2,1-12H3,(H,66,76)(H,68,78)(H,67,73,77)/t42-,43+,44+,48-,49?,50+,54-,55-,56-,57+,58+/m0/s1","WWDSYKAVVVERQX-BAPZVFFDSA-N"
"1337","","Alpha-tubulin","CRBN","","BJG-03-089","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCOCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","58.37","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1383.73","1382.82002343","4.15","98","5","21","5","50","310.17","C71H114N8O19","InChI=1S/C71H114N8O19/c1-13-49(6)63(57(89-11)46-59(81)78-29-18-24-55(78)65(90-12)50(7)66(83)73-51(8)64(82)52-20-15-14-16-21-52)77(10)71(88)61(47(2)3)75-68(85)62(48(4)5)76(9)28-19-30-91-32-34-93-36-38-95-40-42-97-44-45-98-43-41-96-39-37-94-35-33-92-31-27-72-54-23-17-22-53-60(54)70(87)79(69(53)86)56-25-26-58(80)74-67(56)84/h14-17,20-23,47-51,55-57,61-65,72,82H,13,18-19,24-46H2,1-12H3,(H,73,83)(H,75,85)(H,74,80,84)/t49-,50+,51+,55-,56?,57+,61-,62-,63-,64+,65+/m0/s1","SMPBMEBFSPMGRU-AKHISFFYSA-N"
"1337","P07437","Beta-tubulin","CRBN","","BJG-03-089","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)CCCOCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","58.37","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1383.73","1382.82002343","4.15","98","5","21","5","50","310.17","C71H114N8O19","InChI=1S/C71H114N8O19/c1-13-49(6)63(57(89-11)46-59(81)78-29-18-24-55(78)65(90-12)50(7)66(83)73-51(8)64(82)52-20-15-14-16-21-52)77(10)71(88)61(47(2)3)75-68(85)62(48(4)5)76(9)28-19-30-91-32-34-93-36-38-95-40-42-97-44-45-98-43-41-96-39-37-94-35-33-92-31-27-72-54-23-17-22-53-60(54)70(87)79(69(53)86)56-25-26-58(80)74-67(56)84/h14-17,20-23,47-51,55-57,61-65,72,82H,13,18-19,24-46H2,1-12H3,(H,73,83)(H,75,85)(H,74,80,84)/t49-,50+,51+,55-,56?,57+,61-,62-,63-,64+,65+/m0/s1","SMPBMEBFSPMGRU-AKHISFFYSA-N"
"1338","","Alpha-tubulin","CRBN","","BJG-03-097","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","737.3","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1143.478","1142.69912045","7.61","82","5","13","5","32","253.4","C62H94N8O12","InChI=1S/C62H94N8O12/c1-13-39(6)54(47(81-11)36-50(73)69-35-25-30-45(69)56(82-12)40(7)57(75)64-41(8)55(74)42-26-20-19-21-27-42)68(10)62(80)52(37(2)3)66-59(77)53(38(4)5)67(9)49(72)31-22-17-15-14-16-18-23-34-63-44-29-24-28-43-51(44)61(79)70(60(43)78)46-32-33-48(71)65-58(46)76/h19-21,24,26-29,37-41,45-47,52-56,63,74H,13-18,22-23,25,30-36H2,1-12H3,(H,64,75)(H,66,77)(H,65,71,76)/t39-,40+,41+,45-,46?,47+,52-,53-,54-,55+,56+/m0/s1","DVEXOAJPHYJPPM-ZPVPDCIOSA-N"
"1338","P07437","Beta-tubulin","CRBN","","BJG-03-097","CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)C","","N.D.","","","","","","","","","","","","","","","","","","","","737.3","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","1143.478","1142.69912045","7.61","82","5","13","5","32","253.4","C62H94N8O12","InChI=1S/C62H94N8O12/c1-13-39(6)54(47(81-11)36-50(73)69-35-25-30-45(69)56(82-12)40(7)57(75)64-41(8)55(74)42-26-20-19-21-27-42)68(10)62(80)52(37(2)3)66-59(77)53(38(4)5)67(9)49(72)31-22-17-15-14-16-18-23-34-63-44-29-24-28-43-51(44)61(79)70(60(43)78)46-32-33-48(71)65-58(46)76/h19-21,24,26-29,37-41,45-47,52-56,63,74H,13-18,22-23,25,30-36H2,1-12H3,(H,64,75)(H,66,77)(H,65,71,76)/t39-,40+,41+,45-,46?,47+,52-,53-,54-,55+,56+/m0/s1","DVEXOAJPHYJPPM-ZPVPDCIOSA-N"
"1339","","Alpha-tubulin","CRBN","","BJG-03-081","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","999","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","703.745","703.274109132","4.19","51","5","12","2","18","160.19","C37H41N3O11","InChI=1S/C37H41N3O11/c1-45-28-12-10-23(8-9-24-21-30(46-2)34(48-4)31(22-24)47-3)20-29(28)51-19-18-50-17-16-49-15-14-38-26-7-5-6-25-33(26)37(44)40(36(25)43)27-11-13-32(41)39-35(27)42/h5-10,12,20-22,27,38H,11,13-19H2,1-4H3,(H,39,41,42)/b9-8-","IQNMVISUASHIKH-HJWRWDBZSA-N"
"1339","P07437","Beta-tubulin","CRBN","","BJG-03-081","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","999","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","703.745","703.274109132","4.19","51","5","12","2","18","160.19","C37H41N3O11","InChI=1S/C37H41N3O11/c1-45-28-12-10-23(8-9-24-21-30(46-2)34(48-4)31(22-24)47-3)20-29(28)51-19-18-50-17-16-49-15-14-38-26-7-5-6-25-33(26)37(44)40(36(25)43)27-11-13-32(41)39-35(27)42/h5-10,12,20-22,27,38H,11,13-19H2,1-4H3,(H,39,41,42)/b9-8-","IQNMVISUASHIKH-HJWRWDBZSA-N"
"1340","","Alpha-tubulin","CRBN","","BJG-03-033-1","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","1480","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","747.798","747.30032388","4.04","54","5","13","2","21","169.42","C39H45N3O12","InChI=1S/C39H45N3O12/c1-47-30-12-10-25(8-9-26-23-32(48-2)36(50-4)33(24-26)49-3)22-31(30)54-21-20-53-19-18-52-17-16-51-15-14-40-28-7-5-6-27-35(28)39(46)42(38(27)45)29-11-13-34(43)41-37(29)44/h5-10,12,22-24,29,40H,11,13-21H2,1-4H3,(H,41,43,44)/b9-8-","PTQCPYGJDAZZDW-HJWRWDBZSA-N"
"1340","P07437","Beta-tubulin","CRBN","","BJG-03-033-1","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","1480","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","747.798","747.30032388","4.04","54","5","13","2","21","169.42","C39H45N3O12","InChI=1S/C39H45N3O12/c1-47-30-12-10-25(8-9-26-23-32(48-2)36(50-4)33(24-26)49-3)22-31(30)54-21-20-53-19-18-52-17-16-51-15-14-40-28-7-5-6-27-35(28)39(46)42(38(27)45)29-11-13-34(43)41-37(29)44/h5-10,12,22-24,29,40H,11,13-21H2,1-4H3,(H,41,43,44)/b9-8-","PTQCPYGJDAZZDW-HJWRWDBZSA-N"
"1341","","Alpha-tubulin","CRBN","","BJG-02-158","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","571.6","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","791.851","791.326538628","3.89","57","5","14","2","24","178.65","C41H49N3O13","InChI=1S/C41H49N3O13/c1-49-32-12-10-27(8-9-28-25-34(50-2)38(52-4)35(26-28)51-3)24-33(32)57-23-22-56-21-20-55-19-18-54-17-16-53-15-14-42-30-7-5-6-29-37(30)41(48)44(40(29)47)31-11-13-36(45)43-39(31)46/h5-10,12,24-26,31,42H,11,13-23H2,1-4H3,(H,43,45,46)/b9-8-","NDBWIRIDYPKECW-HJWRWDBZSA-N"
"1341","P07437","Beta-tubulin","CRBN","","BJG-02-158","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","571.6","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","791.851","791.326538628","3.89","57","5","14","2","24","178.65","C41H49N3O13","InChI=1S/C41H49N3O13/c1-49-32-12-10-27(8-9-28-25-34(50-2)38(52-4)35(26-28)51-3)24-33(32)57-23-22-56-21-20-55-19-18-54-17-16-53-15-14-42-30-7-5-6-29-37(30)41(48)44(40(29)47)31-11-13-36(45)43-39(31)46/h5-10,12,24-26,31,42H,11,13-23H2,1-4H3,(H,43,45,46)/b9-8-","NDBWIRIDYPKECW-HJWRWDBZSA-N"
"1342","","Alpha-tubulin","CRBN","","BJG-03-033-2","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","654.5","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","835.904","835.352753376","3.74","60","5","15","2","27","187.88","C43H53N3O14","InChI=1S/C43H53N3O14/c1-51-34-12-10-29(8-9-30-27-36(52-2)40(54-4)37(28-30)53-3)26-35(34)60-25-24-59-23-22-58-21-20-57-19-18-56-17-16-55-15-14-44-32-7-5-6-31-39(32)43(50)46(42(31)49)33-11-13-38(47)45-41(33)48/h5-10,12,26-28,33,44H,11,13-25H2,1-4H3,(H,45,47,48)/b9-8-","KQUUOYNOWGJXDC-HJWRWDBZSA-N"
"1342","P07437","Beta-tubulin","CRBN","","BJG-03-033-2","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1OCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","654.5","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","835.904","835.352753376","3.74","60","5","15","2","27","187.88","C43H53N3O14","InChI=1S/C43H53N3O14/c1-51-34-12-10-29(8-9-30-27-36(52-2)40(54-4)37(28-30)53-3)26-35(34)60-25-24-59-23-22-58-21-20-57-19-18-56-17-16-55-15-14-44-32-7-5-6-31-39(32)43(50)46(42(31)49)33-11-13-38(47)45-41(33)48/h5-10,12,26-28,33,44H,11,13-25H2,1-4H3,(H,45,47,48)/b9-8-","KQUUOYNOWGJXDC-HJWRWDBZSA-N"
"1343","","Alpha-tubulin","CRBN","","BJG-03-144","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","3721","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","790.867","790.34252304","3.9","57","5","14","3","24","181.45","C41H50N4O12","InChI=1S/C41H50N4O12/c1-50-33-12-10-27(8-9-28-25-34(51-2)38(53-4)35(26-28)52-3)24-31(33)43-15-17-55-19-21-57-23-22-56-20-18-54-16-14-42-30-7-5-6-29-37(30)41(49)45(40(29)48)32-11-13-36(46)44-39(32)47/h5-10,12,24-26,32,42-43H,11,13-23H2,1-4H3,(H,44,46,47)/b9-8-","WJAYRCUALBRAAI-HJWRWDBZSA-N"
"1343","P07437","Beta-tubulin","CRBN","","BJG-03-144","COC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","3721","IC50 was tested using BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/cells9051083","790.867","790.34252304","3.9","57","5","14","3","24","181.45","C41H50N4O12","InChI=1S/C41H50N4O12/c1-50-33-12-10-27(8-9-28-25-34(51-2)38(53-4)35(26-28)52-3)24-31(33)43-15-17-55-19-21-57-23-22-56-20-18-54-16-14-42-30-7-5-6-29-37(30)41(49)45(40(29)48)32-11-13-36(46)44-39(32)47/h5-10,12,24-26,32,42-43H,11,13-23H2,1-4H3,(H,44,46,47)/b9-8-","WJAYRCUALBRAAI-HJWRWDBZSA-N"
"1344","P10636","Tau","CRBN","","QC-01-175","O=C(CCC1=CC=C2C(=C1)[NH]C1=CC=NC=C12)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","75/95","Degradation of total tau/P-tau in A152T neurons after 24 h treatment","","","","","","","1200/1700/2500","Kd of Tau WT/A152T/P301L was tested using BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.7554/eLife.45457","626.67","626.248897428","1.96","46","6","9","4","14","171.82","C33H34N6O7","InChI=1S/C33H34N6O7/c40-28(8-5-20-4-6-21-23-19-34-11-10-24(23)37-26(21)18-20)36-13-15-46-17-16-45-14-12-35-25-3-1-2-22-30(25)33(44)39(32(22)43)27-7-9-29(41)38-31(27)42/h1-4,6,10-11,18-19,27,35,37H,5,7-9,12-17H2,(H,36,40)(H,38,41,42)","NWTCZTAQSRLSCP-UHFFFAOYSA-N"
"1345","Q16186","Rpn13","CRBN","","WL40","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCC(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N4C/C(=C\C5=CC=C(Cl)C(Cl)=C5)C(=O)/C(=C/C5=CC=C(Cl)C(Cl)=C5)C4)=C3C2=O)C(=O)N1","","95","Degradation of Rpn13 in MM.1S after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","95-170","Inhibit proliferation of all CD138+ patient cells","","","","","","","","","","","","","","","10.1038/s41375-019-0467-z","1019.763","1017.20770342","6.87","69","7","11","3","20","189.75","C50H47Cl4N5O10","InChI=1S/C50H47Cl4N5O10/c51-36-11-9-31(25-38(36)53)23-33-28-58(29-34(46(33)62)24-32-10-12-37(52)39(54)26-32)49(65)41(27-30-5-2-1-3-6-30)56-44(61)15-17-67-19-21-69-22-20-68-18-16-55-40-8-4-7-35-45(40)50(66)59(48(35)64)42-13-14-43(60)57-47(42)63/h1-12,23-26,41-42,55H,13-22,27-29H2,(H,56,61)(H,57,60,63)/b33-23+,34-24+/t41-,42?/m0/s1","FCHCFQSKNMEXBI-GJMYQHGSSA-N"
"1346","P08069","IGF-1R","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","672.702","672.244480744","4.48","50","7","12","4","13","176.77","C36H32N8O6","InChI=1S/C36H32N8O6/c45-31-13-12-29(33(46)43-31)44-34(47)26-5-3-7-28(32(26)35(44)48)37-16-17-49-18-19-50-25-10-8-23(9-11-25)41-36-38-15-14-30(42-36)40-24-20-22-4-1-2-6-27(22)39-21-24/h1-11,14-15,20-21,29,37H,12-13,16-19H2,(H,43,45,46)(H2,38,40,41,42)","BLGABOHGKRXYSB-UHFFFAOYSA-N"
"1346","P12931","Src","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","672.702","672.244480744","4.48","50","7","12","4","13","176.77","C36H32N8O6","InChI=1S/C36H32N8O6/c45-31-13-12-29(33(46)43-31)44-34(47)26-5-3-7-28(32(26)35(44)48)37-16-17-49-18-19-50-25-10-8-23(9-11-25)41-36-38-15-14-30(42-36)40-24-20-22-4-1-2-6-27(22)39-21-24/h1-11,14-15,20-21,29,37H,12-13,16-19H2,(H,43,45,46)(H2,38,40,41,42)","BLGABOHGKRXYSB-UHFFFAOYSA-N"
"1347","P08069","IGF-1R","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","716.755","716.270695492","4.33","53","7","13","4","16","186.0","C38H36N8O7","InChI=1S/C38H36N8O7/c47-33-13-12-31(35(48)45-33)46-36(49)28-5-3-7-30(34(28)37(46)50)39-16-17-51-18-19-52-20-21-53-27-10-8-25(9-11-27)43-38-40-15-14-32(44-38)42-26-22-24-4-1-2-6-29(24)41-23-26/h1-11,14-15,22-23,31,39H,12-13,16-21H2,(H,45,47,48)(H2,40,42,43,44)","VQLXJBPQVMWNGC-UHFFFAOYSA-N"
"1347","P12931","Src","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","716.755","716.270695492","4.33","53","7","13","4","16","186.0","C38H36N8O7","InChI=1S/C38H36N8O7/c47-33-13-12-31(35(48)45-33)46-36(49)28-5-3-7-30(34(28)37(46)50)39-16-17-51-18-19-52-20-21-53-27-10-8-25(9-11-27)43-38-40-15-14-32(44-38)42-26-22-24-4-1-2-6-29(24)41-23-26/h1-11,14-15,22-23,31,39H,12-13,16-21H2,(H,45,47,48)(H2,40,42,43,44)","VQLXJBPQVMWNGC-UHFFFAOYSA-N"
"1348","P08069","IGF-1R","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","760.808","760.29691024","4.18","56","7","14","4","19","195.23","C40H40N8O8","InChI=1S/C40H40N8O8/c49-35-13-12-33(37(50)47-35)48-38(51)30-5-3-7-32(36(30)39(48)52)41-16-17-53-18-19-54-20-21-55-22-23-56-29-10-8-27(9-11-29)45-40-42-15-14-34(46-40)44-28-24-26-4-1-2-6-31(26)43-25-28/h1-11,14-15,24-25,33,41H,12-13,16-23H2,(H,47,49,50)(H2,42,44,45,46)","NNFLJXWHNNZGBH-UHFFFAOYSA-N"
"1348","P12931","Src","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOC4=CC=C(NC5=NC=CC(NC6=CN=C7C=CC=CC7=C6)=N5)C=C4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","760.808","760.29691024","4.18","56","7","14","4","19","195.23","C40H40N8O8","InChI=1S/C40H40N8O8/c49-35-13-12-33(37(50)47-35)48-38(51)30-5-3-7-32(36(30)39(48)52)41-16-17-53-18-19-54-20-21-55-22-23-56-29-10-8-27(9-11-29)45-40-42-15-14-34(46-40)44-28-24-26-4-1-2-6-31(26)43-25-28/h1-11,14-15,24-25,33,41H,12-13,16-23H2,(H,47,49,50)(H2,42,44,45,46)","NNFLJXWHNNZGBH-UHFFFAOYSA-N"
"1349","P08069","IGF-1R","CRBN","","CPR3","CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=N2)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.3/4.2","Inhibit growth of MCF7/A549 cells","","","","","","","","","","","","","","","10.3390/molecules25081948","625.646","625.239729712","3.24","46","6","12","5","13","192.56","C31H31N9O6","InChI=1S/C31H31N9O6/c1-18-17-25(39-38-18)35-24-11-12-33-31(36-24)34-19-5-7-20(8-6-19)46-16-15-45-14-13-32-22-4-2-3-21-27(22)30(44)40(29(21)43)23-9-10-26(41)37-28(23)42/h2-8,11-12,17,23,32H,9-10,13-16H2,1H3,(H,37,41,42)(H3,33,34,35,36,38,39)","YEBGDZYCAZJQHH-UHFFFAOYSA-N"
"1349","P12931","Src","CRBN","","CPR3","CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=N2)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.3/4.2","Inhibit growth of MCF7/A549 cells","","","","","","","","","","","","","","","10.3390/molecules25081948","625.646","625.239729712","3.24","46","6","12","5","13","192.56","C31H31N9O6","InChI=1S/C31H31N9O6/c1-18-17-25(39-38-18)35-24-11-12-33-31(36-24)34-19-5-7-20(8-6-19)46-16-15-45-14-13-32-22-4-2-3-21-27(22)30(44)40(29(21)43)23-9-10-26(41)37-28(23)42/h2-8,11-12,17,23,32H,9-10,13-16H2,1H3,(H,37,41,42)(H3,33,34,35,36,38,39)","YEBGDZYCAZJQHH-UHFFFAOYSA-N"
"1350","P08069","IGF-1R","CRBN","","CPR4","CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=N2)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.7/7.6","Inhibit growth of MCF7/A549 cells","","","","","","","","","","","","","","","10.3390/molecules25081948","669.699","669.26594446","3.09","49","6","13","5","16","201.79","C33H35N9O7","InChI=1S/C33H35N9O7/c1-20-19-27(41-40-20)37-26-11-12-35-33(38-26)36-21-5-7-22(8-6-21)49-18-17-48-16-15-47-14-13-34-24-4-2-3-23-29(24)32(46)42(31(23)45)25-9-10-28(43)39-30(25)44/h2-8,11-12,19,25,34H,9-10,13-18H2,1H3,(H,39,43,44)(H3,35,36,37,38,40,41)","KSJXWXGDPRCSIV-UHFFFAOYSA-N"
"1350","P12931","Src","CRBN","","CPR4","CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=N2)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.7/7.6","Inhibit growth of MCF7/A549 cells","","","","","","","","","","","","","","","10.3390/molecules25081948","669.699","669.26594446","3.09","49","6","13","5","16","201.79","C33H35N9O7","InChI=1S/C33H35N9O7/c1-20-19-27(41-40-20)37-26-11-12-35-33(38-26)36-21-5-7-22(8-6-21)49-18-17-48-16-15-47-14-13-34-24-4-2-3-23-29(24)32(46)42(31(23)45)25-9-10-28(43)39-30(25)44/h2-8,11-12,19,25,34H,9-10,13-18H2,1H3,(H,39,43,44)(H3,35,36,37,38,40,41)","KSJXWXGDPRCSIV-UHFFFAOYSA-N"
"1351","P08069","IGF-1R","CRBN","","","CC1=CC(NC2=NC(NC3=CC=C(OCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2Cl)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","660.091","659.20075736","3.87","47","6","12","5","13","192.56","C31H30ClN9O6","InChI=1S/C31H30ClN9O6/c1-17-15-24(40-39-17)36-27-21(32)16-34-31(38-27)35-18-5-7-19(8-6-18)47-14-13-46-12-11-33-22-4-2-3-20-26(22)30(45)41(29(20)44)23-9-10-25(42)37-28(23)43/h2-8,15-16,23,33H,9-14H2,1H3,(H,37,42,43)(H3,34,35,36,38,39,40)","IOHSXHAPQQQUGP-UHFFFAOYSA-N"
"1351","P12931","Src","CRBN","","","CC1=CC(NC2=NC(NC3=CC=C(OCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2Cl)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","660.091","659.20075736","3.87","47","6","12","5","13","192.56","C31H30ClN9O6","InChI=1S/C31H30ClN9O6/c1-17-15-24(40-39-17)36-27-21(32)16-34-31(38-27)35-18-5-7-19(8-6-18)47-14-13-46-12-11-33-22-4-2-3-20-26(22)30(45)41(29(20)44)23-9-10-25(42)37-28(23)43/h2-8,15-16,23,33H,9-14H2,1H3,(H,37,42,43)(H3,34,35,36,38,39,40)","IOHSXHAPQQQUGP-UHFFFAOYSA-N"
"1352","P08069","IGF-1R","CRBN","","","CC1=CC(NC2=NC(NC3=CC=C(OCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2Cl)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","704.144","703.226972108","3.72","50","6","13","5","16","201.79","C33H34ClN9O7","InChI=1S/C33H34ClN9O7/c1-19-17-26(42-41-19)38-29-23(34)18-36-33(40-29)37-20-5-7-21(8-6-20)50-16-15-49-14-13-48-12-11-35-24-4-2-3-22-28(24)32(47)43(31(22)46)25-9-10-27(44)39-30(25)45/h2-8,17-18,25,35H,9-16H2,1H3,(H,39,44,45)(H3,36,37,38,40,41,42)","UYDSYJMBAOFSTK-UHFFFAOYSA-N"
"1352","P12931","Src","CRBN","","","CC1=CC(NC2=NC(NC3=CC=C(OCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C2Cl)=N[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","704.144","703.226972108","3.72","50","6","13","5","16","201.79","C33H34ClN9O7","InChI=1S/C33H34ClN9O7/c1-19-17-26(42-41-19)38-29-23(34)18-36-33(40-29)37-20-5-7-21(8-6-20)50-16-15-49-14-13-48-12-11-35-24-4-2-3-22-28(24)32(47)43(31(22)46)25-9-10-27(44)39-30(25)45/h2-8,17-18,25,35H,9-16H2,1H3,(H,39,44,45)(H3,36,37,38,40,41,42)","UYDSYJMBAOFSTK-UHFFFAOYSA-N"
"1353","P08069","IGF-1R","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCNC1=CC=C(OCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","738.205","737.247707552","4.36","53","7","13","4","15","195.69","C37H36ClN9O6","InChI=1S/C37H36ClN9O6/c38-23-7-5-22(6-8-23)32-31-33(39)42-21-43-34(31)46(45-32)17-2-15-40-24-9-11-25(12-10-24)53-20-19-52-18-16-41-27-4-1-3-26-30(27)37(51)47(36(26)50)28-13-14-29(48)44-35(28)49/h1,3-12,21,28,40-41H,2,13-20H2,(H2,39,42,43)(H,44,48,49)","XWGDNKJJVPSPJY-UHFFFAOYSA-N"
"1353","P12931","Src","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCNC1=CC=C(OCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","738.205","737.247707552","4.36","53","7","13","4","15","195.69","C37H36ClN9O6","InChI=1S/C37H36ClN9O6/c38-23-7-5-22(6-8-23)32-31-33(39)42-21-43-34(31)46(45-32)17-2-15-40-24-9-11-25(12-10-24)53-20-19-52-18-16-41-27-4-1-3-26-30(27)37(51)47(36(26)50)28-13-14-29(48)44-35(28)49/h1,3-12,21,28,40-41H,2,13-20H2,(H2,39,42,43)(H,44,48,49)","XWGDNKJJVPSPJY-UHFFFAOYSA-N"
"1354","P08069","IGF-1R","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCNC1=CC=C(OCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","782.258","781.2739223","4.21","56","7","14","4","18","204.92","C39H40ClN9O7","InChI=1S/C39H40ClN9O7/c40-25-7-5-24(6-8-25)34-33-35(41)44-23-45-36(33)48(47-34)17-2-15-42-26-9-11-27(12-10-26)56-22-21-55-20-19-54-18-16-43-29-4-1-3-28-32(29)39(53)49(38(28)52)30-13-14-31(50)46-37(30)51/h1,3-12,23,30,42-43H,2,13-22H2,(H2,41,44,45)(H,46,50,51)","ZOQUWFJXKUZLHH-UHFFFAOYSA-N"
"1354","P12931","Src","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCNC1=CC=C(OCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","782.258","781.2739223","4.21","56","7","14","4","18","204.92","C39H40ClN9O7","InChI=1S/C39H40ClN9O7/c40-25-7-5-24(6-8-25)34-33-35(41)44-23-45-36(33)48(47-34)17-2-15-42-26-9-11-27(12-10-26)56-22-21-55-20-19-54-18-16-43-29-4-1-3-28-32(29)39(53)49(38(28)52)30-13-14-31(50)46-37(30)51/h1,3-12,23,30,42-43H,2,13-22H2,(H2,41,44,45)(H,46,50,51)","ZOQUWFJXKUZLHH-UHFFFAOYSA-N"
"1355","P08069","IGF-1R","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCN1C=C(CNC2=CC=C(OCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","819.283","818.280404648","3.59","59","8","16","4","17","226.4","C40H39ClN12O6","InChI=1S/C40H39ClN12O6/c41-25-7-5-24(6-8-25)35-34-36(42)45-23-46-37(34)52(49-35)17-2-16-51-22-27(48-50-51)21-44-26-9-11-28(12-10-26)59-20-19-58-18-15-43-30-4-1-3-29-33(30)40(57)53(39(29)56)31-13-14-32(54)47-38(31)55/h1,3-12,22-23,31,43-44H,2,13-21H2,(H2,42,45,46)(H,47,54,55)","YEBIAPTXRZULTM-UHFFFAOYSA-N"
"1355","P12931","Src","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCN1C=C(CNC2=CC=C(OCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","819.283","818.280404648","3.59","59","8","16","4","17","226.4","C40H39ClN12O6","InChI=1S/C40H39ClN12O6/c41-25-7-5-24(6-8-25)35-34-36(42)45-23-46-37(34)52(49-35)17-2-16-51-22-27(48-50-51)21-44-26-9-11-28(12-10-26)59-20-19-58-18-15-43-30-4-1-3-29-33(30)40(57)53(39(29)56)31-13-14-32(54)47-38(31)55/h1,3-12,22-23,31,43-44H,2,13-21H2,(H2,42,45,46)(H,47,54,55)","YEBIAPTXRZULTM-UHFFFAOYSA-N"
"1356","P08069","IGF-1R","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCN1C=C(CNC2=CC=C(OCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","863.336","862.306619396","3.44","62","8","17","4","20","235.63","C42H43ClN12O7","InChI=1S/C42H43ClN12O7/c43-27-7-5-26(6-8-27)37-36-38(44)47-25-48-39(36)54(51-37)17-2-16-53-24-29(50-52-53)23-46-28-9-11-30(12-10-28)62-22-21-61-20-19-60-18-15-45-32-4-1-3-31-35(32)42(59)55(41(31)58)33-13-14-34(56)49-40(33)57/h1,3-12,24-25,33,45-46H,2,13-23H2,(H2,44,47,48)(H,49,56,57)","UPKHTGRZRRRAME-UHFFFAOYSA-N"
"1356","P12931","Src","CRBN","","","NC1=NC=NC2=C1C(C1=CC=C(Cl)C=C1)=NN2CCCN1C=C(CNC2=CC=C(OCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25081948","863.336","862.306619396","3.44","62","8","17","4","20","235.63","C42H43ClN12O7","InChI=1S/C42H43ClN12O7/c43-27-7-5-26(6-8-27)37-36-38(44)47-25-48-39(36)54(51-37)17-2-16-53-24-29(50-52-53)23-46-28-9-11-30(12-10-28)62-22-21-61-20-19-60-18-15-45-32-4-1-3-31-35(32)42(59)55(41(31)58)33-13-14-34(56)49-40(33)57/h1,3-12,24-25,33,45-46H,2,13-23H2,(H2,44,47,48)(H,49,56,57)","UPKHTGRZRRRAME-UHFFFAOYSA-N"
"1357","","NS3","CRBN","","DGY-03-081","CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C1=CN=C(C(=O)NCCCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=N1)C1CCCCC1)C(C)(C)C)C(=O)C(=O)NC1CC1","669","","Degradation of NS3 in Huh7.5 cells after 4 h treatment","","","385","Inhibition of NS3","","","","","","","","","","","","","","","","","576","EC50 was tested using a BRD4 BRD2-eGFP-mCherry reporter assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3069","IC50 of antiviral activity against HCV in Huh7.5 cells","","","","","","","","","","","","","","","10.1038/s41467-019-11429-w","1064.299","1063.58548766","5.17","77","8","13","7","23","287.17","C56H77N11O10","InChI=1S/C56H77N11O10/c1-5-15-39(46(69)53(75)61-34-22-23-34)62-52(74)45-35-19-13-18-33(35)30-67(45)55(77)47(56(2,3)4)65-51(73)44(32-16-9-8-10-17-32)64-49(71)41-29-59-40(28-60-41)48(70)58-27-12-7-6-11-26-57-38-21-14-20-36-37(38)31-66(54(36)76)42-24-25-43(68)63-50(42)72/h14,20-21,28-29,32-35,39,42,44-45,47,57H,5-13,15-19,22-27,30-31H2,1-4H3,(H,58,70)(H,61,75)(H,62,74)(H,64,71)(H,65,73)(H,63,68,72)/t33-,35-,39-,42?,44-,45-,47+/m0/s1","KJEYLCKKOBCAHO-KSESKIPOSA-N"
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"1368","Q06187","BTK","CRBN","","","C=CC(=O)N1C[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C[C@H]1C(=O)NCCCCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","909.061","908.433344132","7.71","67","8","13","4","21","223.84","C50H56N10O7","InChI=1S/C50H56N10O7/c1-2-41(62)58-30-33(60-46-43(45(51)54-31-55-46)44(57-60)32-21-23-35(24-22-32)67-34-17-12-11-13-18-34)29-39(58)47(63)53-28-15-10-8-6-4-3-5-7-9-14-27-52-37-20-16-19-36-42(37)50(66)59(49(36)65)38-25-26-40(61)56-48(38)64/h2,11-13,16-24,31,33,38-39,52H,1,3-10,14-15,25-30H2,(H,53,63)(H2,51,54,55)(H,56,61,64)/t33-,38?,39-/m0/s1","GCASCEBFNIUXDL-KJJQOZBJSA-N"
"1369","Q06187","BTK","CRBN","","","C=CC(=O)N[C@@H](CCC(=O)OCCOCCOCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1091.026","1090.34326629","3.69","79","7","16","7","23","311.62","C53H49F3N10O13","InChI=1S/C53H49F3N10O13/c1-3-41(67)64-39(15-18-44(70)79-22-21-77-19-20-78-28-43(69)63-38-12-6-11-36-45(38)51(76)66(50(36)75)40-16-17-42(68)65-49(40)74)48(73)60-32-9-5-10-33(24-32)62-52-57-26-35(27-58-52)61-47(72)37-25-34(14-13-29(37)2)59-46(71)30-7-4-8-31(23-30)53(54,55)56/h3-14,23-27,39-40H,1,15-22,28H2,2H3,(H,59,71)(H,60,73)(H,61,72)(H,63,69)(H,64,67)(H,57,58,62)(H,65,68,74)/t39-,40?/m0/s1","PCXTWXFSFHDOEM-KLBOFATRSA-N"
"1370","Q06187","BTK","CRBN","","","C=CC(=O)N[C@@H](CCC(=O)OCCOCCOCCOCCOCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1179.132","1178.39569578","3.39","85","7","18","7","29","330.08","C57H57F3N10O15","InChI=1S/C57H57F3N10O15/c1-3-45(71)68-43(15-18-48(74)85-26-25-83-22-21-81-19-20-82-23-24-84-32-47(73)67-42-12-6-11-40-49(42)55(80)70(54(40)79)44-16-17-46(72)69-53(44)78)52(77)64-36-9-5-10-37(28-36)66-56-61-30-39(31-62-56)65-51(76)41-29-38(14-13-33(41)2)63-50(75)34-7-4-8-35(27-34)57(58,59)60/h3-14,27-31,43-44H,1,15-26,32H2,2H3,(H,63,75)(H,64,77)(H,65,76)(H,67,73)(H,68,71)(H,61,62,66)(H,69,72,78)/t43-,44?/m0/s1","JOQYNKATGRALEV-XASUVLGYSA-N"
"1371","Q06187","BTK","CRBN","","","C=CC(=O)N[C@@H](CCC(=O)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1016.007","1015.35885678","4.9","74","7","13","8","20","278.89","C51H48F3N11O9","InChI=1S/C51H48F3N11O9/c1-3-40(66)63-38(17-19-41(67)56-22-5-4-21-55-37-14-8-13-35-43(37)49(74)65(48(35)73)39-18-20-42(68)64-47(39)72)46(71)60-31-11-7-12-32(24-31)62-50-57-26-34(27-58-50)61-45(70)36-25-33(16-15-28(36)2)59-44(69)29-9-6-10-30(23-29)51(52,53)54/h3,6-16,23-27,38-39,55H,1,4-5,17-22H2,2H3,(H,56,67)(H,59,69)(H,60,71)(H,61,70)(H,63,66)(H,57,58,62)(H,64,68,72)/t38-,39?/m0/s1","FANGQAUCOUNFLH-SQTCDLSVSA-N"
"1372","Q06187","BTK","CRBN","","","C=CC(=O)N[C@@H](CCC(=O)NCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","186","IC50 was tested by the HTRF KinEase assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1072.115","1071.42145703","6.7","78","7","13","8","24","278.89","C55H56F3N11O9","InChI=1S/C55H56F3N11O9/c1-3-44(70)67-42(21-23-45(71)60-26-9-7-5-4-6-8-25-59-41-18-12-17-39-47(41)53(78)69(52(39)77)43-22-24-46(72)68-51(43)76)50(75)64-35-15-11-16-36(28-35)66-54-61-30-38(31-62-54)65-49(74)40-29-37(20-19-32(40)2)63-48(73)33-13-10-14-34(27-33)55(56,57)58/h3,10-20,27-31,42-43,59H,1,4-9,21-26H2,2H3,(H,60,71)(H,63,73)(H,64,75)(H,65,74)(H,67,70)(H,61,62,66)(H,68,72,76)/t42-,43?/m0/s1","NWODTWNJDJJNBY-ZAGGQVEOSA-N"
"1373","Q06187","BTK","VHL","","","C=CC(=O)N1C[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C[C@H]1C(=O)OCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","136","88","Degradation of BTK in K562 cells after 18 h treatment","","","39","IC50 was tested by the HTRF KinEase assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1029.19","1028.42145912","4.99","74","8","17","4","20","255.55","C53H60N10O10S","InChI=1S/C53H60N10O10S/c1-6-43(66)61-27-36(63-49-44(48(54)56-30-57-49)45(60-63)34-16-18-39(19-17-34)73-38-10-8-7-9-11-38)24-41(61)52(69)72-23-22-70-20-21-71-29-42(65)59-47(53(3,4)5)51(68)62-28-37(64)25-40(62)50(67)55-26-33-12-14-35(15-13-33)46-32(2)58-31-74-46/h6-19,30-31,36-37,40-41,47,64H,1,20-29H2,2-5H3,(H,55,67)(H,59,65)(H2,54,56,57)/t36-,37+,40-,41-,47+/m0/s1","JQIURFOHEWHROK-WNKYWPOYSA-N"
"1373","P51451","BLK","VHL","","","C=CC(=O)N1C[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C[C@H]1C(=O)OCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","220","75","Degradation of BLK in Ramos cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1029.19","1028.42145912","4.99","74","8","17","4","20","255.55","C53H60N10O10S","InChI=1S/C53H60N10O10S/c1-6-43(66)61-27-36(63-49-44(48(54)56-30-57-49)45(60-63)34-16-18-39(19-17-34)73-38-10-8-7-9-11-38)24-41(61)52(69)72-23-22-70-20-21-71-29-42(65)59-47(53(3,4)5)51(68)62-28-37(64)25-40(62)50(67)55-26-33-12-14-35(15-13-33)46-32(2)58-31-74-46/h6-19,30-31,36-37,40-41,47,64H,1,20-29H2,2-5H3,(H,55,67)(H,59,65)(H2,54,56,57)/t36-,37+,40-,41-,47+/m0/s1","JQIURFOHEWHROK-WNKYWPOYSA-N"
"1374","Q06187","BTK","VHL","","","C=CC(=O)N[C@@H](CCC(=O)NCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1243.424","1242.52962758","7.92","89","7","14","9","27","294.94","C64H73F3N12O9S","InChI=1S/C64H73F3N12O9S/c1-7-52(81)77-50(59(86)74-44-17-14-18-45(30-44)76-62-70-34-47(35-71-62)75-58(85)49-31-46(25-20-38(49)2)73-57(84)42-15-13-16-43(29-42)64(65,66)67)26-27-53(82)68-28-12-10-8-9-11-19-54(83)78-56(63(4,5)6)61(88)79-36-48(80)32-51(79)60(87)69-33-40-21-23-41(24-22-40)55-39(3)72-37-89-55/h7,13-18,20-25,29-31,34-35,37,48,50-51,56,80H,1,8-12,19,26-28,32-33,36H2,2-6H3,(H,68,82)(H,69,87)(H,73,84)(H,74,86)(H,75,85)(H,77,81)(H,78,83)(H,70,71,76)/t48-,50+,51+,56-/m1/s1","MFLHDWYBZIKFHQ-QNOKFCAYSA-N"
"1375","Q06187","BTK","VHL","","","CCC(=O)N1C[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C[C@H]1C(=O)OCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","2657","IC50 was tested by the HTRF KinEase assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1031.206","1030.43710918","4.87","74","8","17","4","20","255.55","C53H62N10O10S","InChI=1S/C53H62N10O10S/c1-6-43(66)61-27-36(63-49-44(48(54)56-30-57-49)45(60-63)34-16-18-39(19-17-34)73-38-10-8-7-9-11-38)24-41(61)52(69)72-23-22-70-20-21-71-29-42(65)59-47(53(3,4)5)51(68)62-28-37(64)25-40(62)50(67)55-26-33-12-14-35(15-13-33)46-32(2)58-31-74-46/h7-19,30-31,36-37,40-41,47,64H,6,20-29H2,1-5H3,(H,55,67)(H,59,65)(H2,54,56,57)/t36-,37+,40-,41-,47+/m0/s1","SBPISOPLAQWPMK-WNKYWPOYSA-N"
"1376","Q06187","BTK","CRBN","","","CCC(=O)N[C@@H](CCC(=O)NCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC(NC2=NC=C(NC(=O)C3=CC(NC(=O)C4=CC=CC(C(F)(F)F)=C4)=CC=C3C)C=N2)=C1","","","","","","415","IC50 was tested by the HTRF KinEase assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/c9cc08238g","1074.131","1073.4371071","6.58","78","7","13","8","24","278.89","C55H58F3N11O9","InChI=1S/C55H58F3N11O9/c1-3-44(70)67-42(21-23-45(71)60-26-9-7-5-4-6-8-25-59-41-18-12-17-39-47(41)53(78)69(52(39)77)43-22-24-46(72)68-51(43)76)50(75)64-35-15-11-16-36(28-35)66-54-61-30-38(31-62-54)65-49(74)40-29-37(20-19-32(40)2)63-48(73)33-13-10-14-34(27-33)55(56,57)58/h10-20,27-31,42-43,59H,3-9,21-26H2,1-2H3,(H,60,71)(H,63,73)(H,64,75)(H,65,74)(H,67,70)(H,61,62,66)(H,68,72,76)/t42-,43?/m0/s1","WMTHTEGTLNZUNZ-ZAGGQVEOSA-N"
"1377","P49336","CDK8","CRBN","","","CN(CCCCCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)[C@H]1CC[C@@]2(C)C(CC[C@@H]3C2CC[C@]2(C)[C@@H](C4=CC=C5C=CN=CC5=C4)CC[C@@H]32)C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.8b00011","860.153","859.524784928","9.58","63","9","9","2","17","130.17","C52H69N5O6","InChI=1S/C52H69N5O6/c1-51-22-19-38(32-37(51)13-14-39-42-16-15-41(52(42,2)23-20-43(39)51)35-12-11-34-21-24-53-33-36(34)31-35)56(3)26-6-4-5-7-27-62-29-30-63-28-25-54-44-10-8-9-40-47(44)50(61)57(49(40)60)45-17-18-46(58)55-48(45)59/h8-12,21,24,31,33,37-39,41-43,45,54H,4-7,13-20,22-23,25-30,32H2,1-3H3,(H,55,58,59)/t37?,38-,39-,41+,42-,43?,45?,51-,52+/m0/s1","SKQVKRNHHYLQNC-VUCSNLQTSA-N"
"1378","P49336","CDK8","CRBN","","JH-XI-10-02","CN(C(=O)CCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)[C@H]1CC[C@@]2(C)C(CC[C@@H]3C2CC[C@]2(C)[C@@H](C4=CC=C5C=CN=CC5=C4)CC[C@@H]32)C1","","","","","","159","Inhibition of CDK8","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.8b00011","920.161","919.509528788","7.25","67","9","11","2","19","165.7","C53H69N5O9","InChI=1S/C53H69N5O9/c1-52-19-15-38(32-37(52)9-10-39-42-12-11-41(53(42,2)20-16-43(39)52)35-8-7-34-17-21-54-33-36(34)31-35)57(3)47(60)18-23-64-25-27-66-29-30-67-28-26-65-24-22-55-44-6-4-5-40-48(44)51(63)58(50(40)62)45-13-14-46(59)56-49(45)61/h4-8,17,21,31,33,37-39,41-43,45,55H,9-16,18-20,22-30,32H2,1-3H3,(H,56,59,61)/t37?,38-,39-,41+,42-,43?,45?,52-,53+/m0/s1","JECHBTRAPARMGI-KMIZWFMDSA-N"
"1379","P49336","CDK8","CRBN","","","CN(C(=O)CCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)[C@H]1CC[C@@]2(C)C(CC[C@@H]3C2CC[C@]2(C)[C@@H](C4=CC=C5C=CN=CC5=C4)CC[C@@H]32)C1","","N.D.","","","","192","Inhibition of CDK8","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.8b00011","832.055","831.457099292","7.54","61","9","9","2","13","147.24","C49H61N5O7","InChI=1S/C49H61N5O7/c1-48-19-15-34(28-33(48)9-10-35-38-12-11-37(49(38,2)20-16-39(35)48)31-8-7-30-17-21-50-29-32(30)27-31)53(3)43(56)18-23-60-25-26-61-24-22-51-40-6-4-5-36-44(40)47(59)54(46(36)58)41-13-14-42(55)52-45(41)57/h4-8,17,21,27,29,33-35,37-39,41,51H,9-16,18-20,22-26,28H2,1-3H3,(H,52,55,57)/t33?,34-,35-,37+,38-,39?,41?,48-,49+/m0/s1","HQBAVLKUBWVLAK-MEBGMWHLSA-N"
"1380","Q06187","BTK","CRBN","","NC-1","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCOCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","2.2","97","Degradation of BTK in Mino cells after 24 h treatment","","","16","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.9b13907","947.059","946.422504676","3.81","69","8","16","2","25","228.86","C50H58N8O11","InChI=1S/C50H58N8O11/c51-46-44-45(34-16-18-37(19-17-34)69-36-11-4-3-5-12-36)55-58(47(44)53-33-52-46)35-10-9-22-56(32-35)42(60)15-6-1-2-7-23-64-24-25-65-26-27-66-28-29-67-30-31-68-40-14-8-13-38-43(40)50(63)57(49(38)62)39-20-21-41(59)54-48(39)61/h3-5,8,11-14,16-19,33,35,39H,1-2,6-7,9-10,15,20-32H2,(H2,51,52,53)(H,54,59,61)/t35-,39?/m1/s1","QSLUWEWRUWTRBT-QQKHLPPFSA-N"
"1381","Q06187","BTK","CRBN","","IR-1","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)/C=C/COCCOCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","8.6","91","Degradation of BTK in Mino cells after 24 h treatment","","","2","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.9b13907","947.015","946.386119168","2.37","69","8","17","2","24","238.09","C49H54N8O12","InChI=1S/C49H54N8O12/c50-45-43-44(33-13-15-36(16-14-33)69-35-8-2-1-3-9-35)54-57(46(43)52-32-51-45)34-7-5-19-55(31-34)41(59)12-6-20-63-21-22-64-23-24-65-25-26-66-27-28-67-29-30-68-39-11-4-10-37-42(39)49(62)56(48(37)61)38-17-18-40(58)53-47(38)60/h1-4,6,8-16,32,34,38H,5,7,17-31H2,(H2,50,51,52)(H,53,58,60)/b12-6+/t34-,38?/m1/s1","AWOLTJZICWTLFS-AHDGVXFFSA-N"
"1382","Q06187","BTK","CRBN","","IR-2","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)/C=C/CCCCOCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","1.9","88","Degradation of BTK in Mino cells after 24 h treatment","","","14","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.9b13907","945.043","944.406854612","3.69","69","8","16","2","24","228.86","C50H56N8O11","InChI=1S/C50H56N8O11/c51-46-44-45(34-16-18-37(19-17-34)69-36-11-4-3-5-12-36)55-58(47(44)53-33-52-46)35-10-9-22-56(32-35)42(60)15-6-1-2-7-23-64-24-25-65-26-27-66-28-29-67-30-31-68-40-14-8-13-38-43(40)50(63)57(49(38)62)39-20-21-41(59)54-48(39)61/h3-6,8,11-19,33,35,39H,1-2,7,9-10,20-32H2,(H2,51,52,53)(H,54,59,61)/b15-6+/t35-,39?/m1/s1","ZJJZBBBSQKVNHL-BYBNZYMESA-N"
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"1393","Q06187","BTK","CRBN","","RC-0h","N#C/C(=C/CCC1=CN(CCOCCOCCOC(=O)NCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.9b13907","1036.076","1035.39874952","2.61","76","9","20","3","22","303.23","C52H53N13O11","InChI=1S/C52H53N13O11/c53-29-34(49(68)62-21-6-9-36(31-62)65-47-44(46(54)56-32-57-47)45(60-65)33-14-16-38(17-15-33)76-37-10-2-1-3-11-37)7-4-8-35-30-63(61-59-35)22-24-72-25-26-73-27-28-75-52(71)55-20-23-74-41-13-5-12-39-43(41)51(70)64(50(39)69)40-18-19-42(66)58-48(40)67/h1-3,5,7,10-17,30,32,36,40H,4,6,8-9,18-28,31H2,(H,55,71)(H2,54,56,57)(H,58,66,67)/b34-7-/t36-,40?/m1/s1","WTOVIXLJDYFDNO-TWTNBJNSSA-N"
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"1395","Q06187","BTK","CRBN","","RC-0j","N#C/C(=C/CCC1=CN(CCOCCOCCOCCOCCOCCOC(=O)NCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.9b13907","1168.235","1167.47739376","2.17","85","9","23","3","31","330.92","C58H65N13O14","InChI=1S/C58H65N13O14/c59-35-40(55(74)68-21-6-9-42(37-68)71-53-50(52(60)62-38-63-53)51(66-71)39-14-16-44(17-15-39)85-43-10-2-1-3-11-43)7-4-8-41-36-69(67-65-41)22-24-78-25-26-79-27-28-80-29-30-81-31-32-82-33-34-84-58(77)61-20-23-83-47-13-5-12-45-49(47)57(76)70(56(45)75)46-18-19-48(72)64-54(46)73/h1-3,5,7,10-17,36,38,42,46H,4,6,8-9,18-34,37H2,(H,61,77)(H2,60,62,63)(H,64,72,73)/b40-7-/t42-,46?/m1/s1","VJMJOGCKUHVNKH-WLHAHUJPSA-N"
"1396","O60885","BRD4","RNF4","","CCW 28-3","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCOC1=CC=C(OC3=CC=C(N(CC4=CC=CC=C4)C(=O)CCl)C=C3)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.8b01083","821.831","820.236530184","8.68","57","7","9","1","15","110.94","C44H42Cl2N6O4S","InChI=1S/C44H42Cl2N6O4S/c1-28-29(2)57-44-41(28)42(32-11-13-33(46)14-12-32)48-38(43-50-49-30(3)52(43)44)25-39(53)47-23-7-8-24-55-35-19-21-37(22-20-35)56-36-17-15-34(16-18-36)51(40(54)26-45)27-31-9-5-4-6-10-31/h4-6,9-22,38H,7-8,23-27H2,1-3H3,(H,47,53)/t38-/m0/s1","WSSWVTZWODGGCO-LHEWISCISA-N"
"1397","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","65.6","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","126.9","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","831.735","830.169238472","4.9","57","7","9","5","12","203.71","C40H36Cl2N6O8S","InChI=1S/C40H36Cl2N6O8S/c1-20-31(18-25-24-17-22(11-12-29(24)46-36(25)50)57(55,56)19-26-27(41)8-6-9-28(26)42)45-21(2)34(20)38(52)44-16-4-3-15-43-30-10-5-7-23-35(30)40(54)48(39(23)53)32-13-14-33(49)47-37(32)51/h5-12,17-18,32,43,45H,3-4,13-16,19H2,1-2H3,(H,44,52)(H,46,50)(H,47,49,51)/b25-18-","FJPAZPYNAOAUBR-BWAHOGKJSA-N"
"1398","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","162.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3983","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","845.762","844.184888536","5.26","58","7","9","5","13","203.71","C41H38Cl2N6O8S","InChI=1S/C41H38Cl2N6O8S/c1-21-32(19-26-25-18-23(12-13-30(25)47-37(26)51)58(56,57)20-27-28(42)9-7-10-29(27)43)46-22(2)35(21)39(53)45-17-5-3-4-16-44-31-11-6-8-24-36(31)41(55)49(40(24)54)33-14-15-34(50)48-38(33)52/h6-13,18-19,33,44,46H,3-5,14-17,20H2,1-2H3,(H,45,53)(H,47,51)(H,48,50,52)/b26-19-","OJIFIHZOVWXFKN-XHPQRKPJSA-N"
"1399","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","92","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1347","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","859.789","858.2005386","5.61","59","7","9","5","14","203.71","C42H40Cl2N6O8S","InChI=1S/C42H40Cl2N6O8S/c1-22-33(20-27-26-19-24(13-14-31(26)48-38(27)52)59(57,58)21-28-29(43)10-8-11-30(28)44)47-23(2)36(22)40(54)46-18-6-4-3-5-17-45-32-12-7-9-25-37(32)42(56)50(41(25)55)34-15-16-35(51)49-39(34)53/h7-14,19-20,34,45,47H,3-6,15-18,21H2,1-2H3,(H,46,54)(H,48,52)(H,49,51,53)/b27-20-","IPUAUTLUOXRXBD-OOAXWGSJSA-N"
"1400","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","89.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7146","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","847.734","846.164153092","4.04","58","7","10","5","13","212.94","C40H36Cl2N6O9S","InChI=1S/C40H36Cl2N6O9S/c1-20-31(18-25-24-17-22(9-10-29(24)46-36(25)50)58(55,56)19-26-27(41)6-4-7-28(26)42)45-21(2)34(20)38(52)44-14-16-57-15-13-43-30-8-3-5-23-35(30)40(54)48(39(23)53)32-11-12-33(49)47-37(32)51/h3-10,17-18,32,43,45H,11-16,19H2,1-2H3,(H,44,52)(H,46,50)(H,47,49,51)/b25-18-","CGIZJKLJZULKRJ-BWAHOGKJSA-N"
"1401","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","33.1","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","634.9","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","891.787","890.19036784","3.89","61","7","11","5","16","222.17","C42H40Cl2N6O10S","InChI=1S/C42H40Cl2N6O10S/c1-22-33(20-27-26-19-24(9-10-31(26)48-38(27)52)61(57,58)21-28-29(43)6-4-7-30(28)44)47-23(2)36(22)40(54)46-14-16-60-18-17-59-15-13-45-32-8-3-5-25-37(32)42(56)50(41(25)55)34-11-12-35(51)49-39(34)53/h3-10,19-20,34,45,47H,11-18,21H2,1-2H3,(H,46,54)(H,48,52)(H,49,51,53)/b27-20-","XXOYGYSMONBBSL-OOAXWGSJSA-N"
"1402","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","121.3","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2272","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","831.735","830.169238472","4.35","57","7","9","5","12","203.71","C40H36Cl2N6O8S","InChI=1S/C40H36Cl2N6O8S/c1-20-32(18-26-25-17-23(9-11-31(25)46-36(26)50)57(55,56)19-28-29(41)6-5-7-30(28)42)45-21(2)35(20)38(52)44-15-4-3-14-43-22-8-10-24-27(16-22)40(54)48(39(24)53)33-12-13-34(49)47-37(33)51/h5-11,16-18,33,43,45H,3-4,12-15,19H2,1-2H3,(H,44,52)(H,46,50)(H,47,49,51)/b26-18-","BMGMTYRURVHRCO-ITYLOYPMSA-N"
"1403","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","69.1","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.7b00969","845.762","844.184888536","4.71","58","7","9","5","13","203.71","C41H38Cl2N6O8S","InChI=1S/C41H38Cl2N6O8S/c1-21-33(19-27-26-18-24(10-12-32(26)47-37(27)51)58(56,57)20-29-30(42)7-6-8-31(29)43)46-22(2)36(21)39(53)45-16-5-3-4-15-44-23-9-11-25-28(17-23)41(55)49(40(25)54)34-13-14-35(50)48-38(34)52/h6-12,17-19,34,44,46H,3-5,13-16,20H2,1-2H3,(H,45,53)(H,47,51)(H,48,50,52)/b27-19-","NEEGBTUUVQFERC-DIBXZPPDSA-N"
"1404","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","32","Kd was determined by KdELECT","","","","","","","","","","","222.8","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","203","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","859.789","858.2005386","5.06","59","7","9","5","14","203.71","C42H40Cl2N6O8S","InChI=1S/C42H40Cl2N6O8S/c1-22-34(20-28-27-19-25(11-13-33(27)48-38(28)52)59(57,58)21-30-31(43)8-7-9-32(30)44)47-23(2)37(22)40(54)46-17-6-4-3-5-16-45-24-10-12-26-29(18-24)42(56)50(41(26)55)35-14-15-36(51)49-39(35)53/h7-13,18-20,35,45,47H,3-6,14-17,21H2,1-2H3,(H,46,54)(H,48,52)(H,49,51,53)/b28-20-","QPKXJIBPFUZACW-RRAHZORUSA-N"
"1405","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","271","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5441","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","887.843","886.231838728","6.15","61","7","9","5","16","203.71","C44H44Cl2N6O8S","InChI=1S/C44H44Cl2N6O8S/c1-24-36(22-30-29-21-27(13-15-35(29)50-40(30)54)61(59,60)23-32-33(45)10-9-11-34(32)46)49-25(2)39(24)42(56)48-19-8-6-4-3-5-7-18-47-26-12-14-28-31(20-26)44(58)52(43(28)57)37-16-17-38(53)51-41(37)55/h9-15,20-22,37,47,49H,3-8,16-19,23H2,1-2H3,(H,48,56)(H,50,54)(H,51,53,55)/b30-22-","LQEMUVVPBROAPO-SWKFRHMKSA-N"
"1406","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","121.3","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2855","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","847.734","846.164153092","3.49","58","7","10","5","13","212.94","C40H36Cl2N6O9S","InChI=1S/C40H36Cl2N6O9S/c1-20-32(18-26-25-17-23(7-9-31(25)46-36(26)50)58(55,56)19-28-29(41)4-3-5-30(28)42)45-21(2)35(20)38(52)44-13-15-57-14-12-43-22-6-8-24-27(16-22)40(54)48(39(24)53)33-10-11-34(49)47-37(33)51/h3-9,16-18,33,43,45H,10-15,19H2,1-2H3,(H,44,52)(H,46,50)(H,47,49,51)/b26-18-","ZXRBZDUGWZPILK-ITYLOYPMSA-N"
"1407","P08581","c-Met","CRBN","","","CC1=C(C(=O)NCCOCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(S(=O)(=O)CC4=C(Cl)C=CC=C4Cl)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","98.5","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1175","Inhibit proliferation of EBC-1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","891.787","890.19036784","3.34","61","7","11","5","16","222.17","C42H40Cl2N6O10S","InChI=1S/C42H40Cl2N6O10S/c1-22-34(20-28-27-19-25(7-9-33(27)48-38(28)52)61(57,58)21-30-31(43)4-3-5-32(30)44)47-23(2)37(22)40(54)46-13-15-60-17-16-59-14-12-45-24-6-8-26-29(18-24)42(56)50(41(26)55)35-10-11-36(51)49-39(35)53/h3-9,18-20,35,45,47H,10-17,21H2,1-2H3,(H,46,54)(H,48,52)(H,49,51,53)/b28-20-","CKRITRWQMXDFMT-RRAHZORUSA-N"
"1408","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","88.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1628/3666","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","684.681","684.234390236","1.79","50","6","8","5","11","195.87","C35H33FN6O8","InChI=1S/C35H33FN6O8/c1-17-24(15-22-21-14-19(36)8-9-23(21)40-31(22)45)39-18(2)29(17)33(47)38-13-4-3-12-37-28(44)16-50-26-7-5-6-20-30(26)35(49)42(34(20)48)25-10-11-27(43)41-32(25)46/h5-9,14-15,25,39H,3-4,10-13,16H2,1-2H3,(H,37,44)(H,38,47)(H,40,45)(H,41,43,46)/b22-15-","LOCVJAKDHSYKJE-JCMHNJIXSA-N"
"1409","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","98.2","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","756.9/1653","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","740.789","740.296990492","3.59","54","6","8","5","15","195.87","C39H41FN6O8","InChI=1S/C39H41FN6O8/c1-21-28(19-26-25-18-23(40)12-13-27(25)44-35(26)49)43-22(2)33(21)37(51)42-17-8-6-4-3-5-7-16-41-32(48)20-54-30-11-9-10-24-34(30)39(53)46(38(24)52)29-14-15-31(47)45-36(29)50/h9-13,18-19,29,43H,3-8,14-17,20H2,1-2H3,(H,41,48)(H,42,51)(H,44,49)(H,45,47,50)/b26-19-","IDASPANZGIUDDY-XHPQRKPJSA-N"
"1410","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCOCCOCCOCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","50","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","923.4/3692","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","816.84","816.31303448","1.35","59","6","11","5","20","223.56","C41H45FN6O11","InChI=1S/C41H45FN6O11/c1-23-30(21-28-27-20-25(42)8-9-29(27)46-37(28)51)45-24(2)35(23)39(53)44-13-5-15-57-17-19-58-18-16-56-14-4-12-43-34(50)22-59-32-7-3-6-26-36(32)41(55)48(40(26)54)31-10-11-33(49)47-38(31)52/h3,6-9,20-21,31,45H,4-5,10-19,22H2,1-2H3,(H,43,50)(H,44,53)(H,46,51)(H,47,49,52)/b28-21-","UZGXKRBUYVKBEY-HFTWOUSFSA-N"
"1411","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","58.5","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","126.2/687.3","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","654.699","654.26021106","3.73","48","6","7","5","11","169.57","C35H35FN6O6","InChI=1S/C35H35FN6O6/c1-18-26(17-23-22-16-20(36)10-11-24(22)40-31(23)44)39-19(2)29(18)33(46)38-15-6-4-3-5-14-37-25-9-7-8-21-30(25)35(48)42(34(21)47)27-12-13-28(43)41-32(27)45/h7-11,16-17,27,37,39H,3-6,12-15H2,1-2H3,(H,38,46)(H,40,44)(H,41,43,45)/b23-17-","VXBLUAKQWQJPAD-QJOMJCCJSA-N"
"1412","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","112.1","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","786.3/2495","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","682.753","682.291511188","4.81","50","6","7","5","13","169.57","C37H39FN6O6","InChI=1S/C37H39FN6O6/c1-20-28(19-25-24-18-22(38)12-13-26(24)42-33(25)46)41-21(2)31(20)35(48)40-17-8-6-4-3-5-7-16-39-27-11-9-10-23-32(27)37(50)44(36(23)49)29-14-15-30(45)43-34(29)47/h9-13,18-19,29,39,41H,3-8,14-17H2,1-2H3,(H,40,48)(H,42,46)(H,43,45,47)/b25-19-","ITHPDQUNEOFFFC-PLRJNAJWSA-N"
"1413","P10721","c-KIT","CRBN","","","CCN(CCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CCNC(=O)C1=C(C)[NH]C(/C=C2\C(=O)NC3=CC=C(F)C=C23)=C1C","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","463.3/2369","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","753.876","753.365010476","5.21","55","6","8","5","17","172.81","C41H48FN7O6","InChI=1S/C41H48FN7O6/c1-4-48(21-19-44-39(53)35-24(2)32(45-25(35)3)23-29-28-22-26(42)14-15-30(28)46-37(29)51)20-10-8-6-5-7-9-18-43-31-13-11-12-27-36(31)41(55)49(40(27)54)33-16-17-34(50)47-38(33)52/h11-15,22-23,33,43,45H,4-10,16-21H2,1-3H3,(H,44,53)(H,46,51)(H,47,50,52)/b29-23-","FGJBRLKBVFBDNO-FAJYDZGRSA-N"
"1414","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC(=O)C2=CC=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","163.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","398.1/1014","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","815.903","815.344275032","5.58","60","7","8","6","16","198.67","C45H46FN7O7","InChI=1S/C45H46FN7O7/c1-25-35(23-32-31-22-29(46)16-17-33(31)51-41(32)56)50-26(2)38(25)43(58)48-21-8-6-4-3-5-7-20-47-40(55)28-14-12-27(13-15-28)24-49-34-11-9-10-30-39(34)45(60)53(44(30)59)36-18-19-37(54)52-42(36)57/h9-17,22-23,36,49-50H,3-8,18-21,24H2,1-2H3,(H,47,55)(H,48,58)(H,51,56)(H,52,54,57)/b32-23-","LTOUXIMRKVFBLW-SJIPCVTESA-N"
"1415","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCNC(=O)C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","125.4","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","581.1/601","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","682.709","682.25512568","2.47","50","6","7","5","11","186.64","C36H35FN6O7","InChI=1S/C36H35FN6O7/c1-18-27(17-24-23-16-21(37)8-10-26(23)41-32(24)46)40-19(2)30(18)34(48)39-14-6-4-3-5-13-38-31(45)20-7-9-22-25(15-20)36(50)43(35(22)49)28-11-12-29(44)42-33(28)47/h7-10,15-17,28,40H,3-6,11-14H2,1-2H3,(H,38,45)(H,39,48)(H,41,46)(H,42,44,47)/b24-17-","JKJVDUVIFSWNLW-ULJHMMPZSA-N"
"1416","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC(=O)C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","201.8","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","488.8/191","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","710.763","710.286425808","3.55","52","6","7","5","13","186.64","C38H39FN6O7","InChI=1S/C38H39FN6O7/c1-20-29(19-26-25-18-23(39)10-12-28(25)43-34(26)48)42-21(2)32(20)36(50)41-16-8-6-4-3-5-7-15-40-33(47)22-9-11-24-27(17-22)38(52)45(37(24)51)30-13-14-31(46)44-35(30)49/h9-12,17-19,30,42H,3-8,13-16H2,1-2H3,(H,40,47)(H,41,50)(H,43,48)(H,44,46,49)/b26-19-","NVHORQOXCJIZIP-XHPQRKPJSA-N"
"1417","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","166.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","68.7/134.7","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","640.672","640.244560996","2.82","47","6","7","5","10","169.57","C34H33FN6O6","InChI=1S/C34H33FN6O6/c1-17-26(16-23-22-14-19(35)6-9-25(22)39-30(23)43)38-18(2)29(17)32(45)37-13-5-3-4-12-36-20-7-8-21-24(15-20)34(47)41(33(21)46)27-10-11-28(42)40-31(27)44/h6-9,14-16,27,36,38H,3-5,10-13H2,1-2H3,(H,37,45)(H,39,43)(H,40,42,44)/b23-16-","DRKUZMFKYGOVRX-KQWNVCNZSA-N"
"1418","P10721","c-KIT","CRBN","","MI-389","CC1=C(C(=O)NCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","0.55","Kd was determined by KdELECT","","","","","","","","","","","48.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41.3/21.3","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","654.699","654.26021106","3.18","48","6","7","5","11","169.57","C35H35FN6O6","InChI=1S/C35H35FN6O6/c1-18-27(17-24-23-15-20(36)7-10-26(23)40-31(24)44)39-19(2)30(18)33(46)38-14-6-4-3-5-13-37-21-8-9-22-25(16-21)35(48)42(34(22)47)28-11-12-29(43)41-32(28)45/h7-10,15-17,28,37,39H,3-6,11-14H2,1-2H3,(H,38,46)(H,40,44)(H,41,43,45)/b24-17-","MHYXTNHNIYFMTQ-ULJHMMPZSA-N"
"1419","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","95.6","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3577/1327","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","682.753","682.291511188","4.26","50","6","7","5","13","169.57","C37H39FN6O6","InChI=1S/C37H39FN6O6/c1-20-29(19-26-25-17-22(38)9-12-28(25)42-33(26)46)41-21(2)32(20)35(48)40-16-8-6-4-3-5-7-15-39-23-10-11-24-27(18-23)37(50)44(36(24)49)30-13-14-31(45)43-34(30)47/h9-12,17-19,30,39,41H,3-8,13-16H2,1-2H3,(H,40,48)(H,42,46)(H,43,45,47)/b26-19-","XBRQMDPTNOTCOX-XHPQRKPJSA-N"
"1420","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCCCCCCCNC(=O)C2=CC=C(CNC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","97.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","388.4/1405","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","815.903","815.344275032","5.03","60","7","8","6","16","198.67","C45H46FN7O7","InChI=1S/C45H46FN7O7/c1-25-36(23-33-32-21-29(46)13-16-35(32)51-41(33)56)50-26(2)39(25)43(58)48-20-8-6-4-3-5-7-19-47-40(55)28-11-9-27(10-12-28)24-49-30-14-15-31-34(22-30)45(60)53(44(31)59)37-17-18-38(54)52-42(37)57/h9-16,21-23,37,49-50H,3-8,17-20,24H2,1-2H3,(H,47,55)(H,48,58)(H,51,56)(H,52,54,57)/b33-23-","NQYMDTVJBQVMJS-SNCSUOKWSA-N"
"1421","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","271.7","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","226.6/1177","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","642.644","642.223825552","1.6","47","6","8","5","10","178.8","C33H31FN6O7","InChI=1S/C33H31FN6O7/c1-16-25(15-22-21-13-18(34)3-6-24(21)38-29(22)42)37-17(2)28(16)31(44)36-10-12-47-11-9-35-19-4-5-20-23(14-19)33(46)40(32(20)45)26-7-8-27(41)39-30(26)43/h3-6,13-15,26,35,37H,7-12H2,1-2H3,(H,36,44)(H,38,42)(H,39,41,43)/b22-15-","KXNAXDRQLDYTGB-JCMHNJIXSA-N"
"1422","P10721","c-KIT","CRBN","","","CC1=C(C(=O)NCCOCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C(C)=C(/C=C2\C(=O)NC3=CC=C(F)C=C23)[NH]1","","N.D.","","","","","","","","","","","","","","","","","","","","216.9","IC50 was tested using the AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","326.4/1873","Inhibit proliferation of GIST-T1/Kasumi 1 cells","","","","","","","","","","","","","10.1021/acschembio.7b00969","686.697","686.2500403","1.45","50","6","9","5","13","188.03","C35H35FN6O8","InChI=1S/C35H35FN6O8/c1-18-27(17-24-23-15-20(36)3-6-26(23)40-31(24)44)39-19(2)30(18)33(46)38-10-12-50-14-13-49-11-9-37-21-4-5-22-25(16-21)35(48)42(34(22)47)28-7-8-29(43)41-32(28)45/h3-6,15-17,28,37,39H,7-14H2,1-2H3,(H,38,46)(H,40,44)(H,41,43,45)/b24-17-","OOJOCFBXSPWHCW-ULJHMMPZSA-N"
"1423","P11802","CDK4","VHL","","YX-2-79","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CC5=CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","1159.385","1158.54330557","2.74","83","9","21","4","24","283.35","C58H74N14O10S","InChI=1S/C58H74N14O10S/c1-36-45-31-61-57(65-53(45)72(42-9-7-8-10-42)55(78)50(36)38(3)73)63-47-16-15-43(30-59-47)68-17-19-69(20-18-68)49(76)27-41-32-70(67-66-41)21-22-80-23-24-81-25-26-82-34-48(75)64-52(58(4,5)6)56(79)71-33-44(74)28-46(71)54(77)60-29-39-11-13-40(14-12-39)51-37(2)62-35-83-51/h11-16,30-32,35,42,44,46,52,74H,7-10,17-29,33-34H2,1-6H3,(H,60,77)(H,64,75)(H,59,61,63,65)/t44-,46+,52-/m1/s1","ATLPEDDHTZYPHP-NQAAHTNFSA-N"
"1423","Q00534","CDK6","VHL","","YX-2-79","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CC5=CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)N=N5)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","176.8","Inhibition of CDK6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","1159.385","1158.54330557","2.74","83","9","21","4","24","283.35","C58H74N14O10S","InChI=1S/C58H74N14O10S/c1-36-45-31-61-57(65-53(45)72(42-9-7-8-10-42)55(78)50(36)38(3)73)63-47-16-15-43(30-59-47)68-17-19-69(20-18-68)49(76)27-41-32-70(67-66-41)21-22-80-23-24-81-25-26-82-34-48(75)64-52(58(4,5)6)56(79)71-33-44(74)28-46(71)54(77)60-29-39-11-13-40(14-12-39)51-37(2)62-35-83-51/h11-16,30-32,35,42,44,46,52,74H,7-10,17-29,33-34H2,1-6H3,(H,60,77)(H,64,75)(H,59,61,63,65)/t44-,46+,52-/m1/s1","ATLPEDDHTZYPHP-NQAAHTNFSA-N"
"1424","P11802","CDK4","CRBN","","AC-1-027","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CN(C)CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","875.944","875.371472148","1.03","64","8","16","3","14","238.44","C44H49N11O9","InChI=1S/C44H49N11O9/c1-25-30-22-47-44(50-39(30)54(27-7-4-5-8-27)42(62)37(25)26(2)56)48-33-13-11-28(21-46-33)52-17-19-53(20-18-52)36(59)23-51(3)16-15-45-35(58)24-64-32-10-6-9-29-38(32)43(63)55(41(29)61)31-12-14-34(57)49-40(31)60/h6,9-11,13,21-22,27,31H,4-5,7-8,12,14-20,23-24H2,1-3H3,(H,45,58)(H,49,57,60)(H,46,47,48,50)","ZIYSXKYRVACHBF-UHFFFAOYSA-N"
"1424","Q00534","CDK6","CRBN","","AC-1-027","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CN(C)CCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","41.94","Inhibition of CDK6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","875.944","875.371472148","1.03","64","8","16","3","14","238.44","C44H49N11O9","InChI=1S/C44H49N11O9/c1-25-30-22-47-44(50-39(30)54(27-7-4-5-8-27)42(62)37(25)26(2)56)48-33-13-11-28(21-46-33)52-17-19-53(20-18-52)36(59)23-51(3)16-15-45-35(58)24-64-32-10-6-9-29-38(32)43(63)55(41(29)61)31-12-14-34(57)49-40(31)60/h6,9-11,13,21-22,27,31H,4-5,7-8,12,14-20,23-24H2,1-3H3,(H,45,58)(H,49,57,60)(H,46,47,48,50)","ZIYSXKYRVACHBF-UHFFFAOYSA-N"
"1425","P11802","CDK4","CRBN","","AC-1-112","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNCCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","994.076","993.434466328","0.12","72","8","19","4","23","274.92","C49H59N11O12","InChI=1S/C49H59N11O12/c1-30-35-27-53-49(56-44(35)59(32-6-3-4-7-32)47(67)42(30)31(2)61)54-38-12-10-33(26-52-38)57-16-18-58(19-17-57)41(64)28-50-14-20-69-22-24-71-25-23-70-21-15-51-40(63)29-72-37-9-5-8-34-43(37)48(68)60(46(34)66)36-11-13-39(62)55-45(36)65/h5,8-10,12,26-27,32,36,50H,3-4,6-7,11,13-25,28-29H2,1-2H3,(H,51,63)(H,55,62,65)(H,52,53,54,56)","MPIQTZCPVQTCBR-UHFFFAOYSA-N"
"1425","Q00534","CDK6","CRBN","","AC-1-112","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNCCOCCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","1142","Inhibition of CDK6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","994.076","993.434466328","0.12","72","8","19","4","23","274.92","C49H59N11O12","InChI=1S/C49H59N11O12/c1-30-35-27-53-49(56-44(35)59(32-6-3-4-7-32)47(67)42(30)31(2)61)54-38-12-10-33(26-52-38)57-16-18-58(19-17-57)41(64)28-50-14-20-69-22-24-71-25-23-70-21-15-51-40(63)29-72-37-9-5-8-34-43(37)48(68)60(46(34)66)36-11-13-39(62)55-45(36)65/h5,8-10,12,26-27,32,36,50H,3-4,6-7,11,13-25,28-29H2,1-2H3,(H,51,63)(H,55,62,65)(H,52,53,54,56)","MPIQTZCPVQTCBR-UHFFFAOYSA-N"
"1426","P11802","CDK4","CRBN","","YX-2-107","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","0.69","Inhibition of CDK4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","95","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","889.971","889.387122212","1.27","65","8","16","4","16","247.23","C45H51N11O9","InChI=1S/C45H51N11O9/c1-26-31-23-49-45(52-40(31)55(28-8-3-4-9-28)43(63)38(26)27(2)57)50-34-14-12-29(22-48-34)53-18-20-54(21-19-53)37(60)24-46-16-5-6-17-47-36(59)25-65-33-11-7-10-30-39(33)44(64)56(42(30)62)32-13-15-35(58)51-41(32)61/h7,10-12,14,22-23,28,32,46H,3-6,8-9,13,15-21,24-25H2,1-2H3,(H,47,59)(H,51,58,61)(H,48,49,50,52)","JNYCZFGLJGFFEL-UHFFFAOYSA-N"
"1426","Q00534","CDK6","CRBN","","YX-2-107","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","4.4","Inhibition of CDK6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","95","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","889.971","889.387122212","1.27","65","8","16","4","16","247.23","C45H51N11O9","InChI=1S/C45H51N11O9/c1-26-31-23-49-45(52-40(31)55(28-8-3-4-9-28)43(63)38(26)27(2)57)50-34-14-12-29(22-48-34)53-18-20-54(21-19-53)37(60)24-46-16-5-6-17-47-36(59)25-65-33-11-7-10-30-39(33)44(64)56(42(30)62)32-13-15-35(58)51-41(32)61/h7,10-12,14,22-23,28,32,46H,3-6,8-9,13,15-21,24-25H2,1-2H3,(H,47,59)(H,51,58,61)(H,48,49,50,52)","JNYCZFGLJGFFEL-UHFFFAOYSA-N"
"1427","P11802","CDK4","MDM2","","YX-2-233","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@](C)(C2=CC=C(Cl)C=C2)[C@@](C)(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCN(C)CC(=O)N2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","1209.338","1207.56533261","8.47","86","10","15","2","17","194.04","C65H79Cl2N13O6","InChI=1S/C65H79Cl2N13O6/c1-10-86-53-37-46(63(4,5)6)19-25-51(53)59-73-64(7,44-15-20-47(66)21-16-44)65(8,45-17-22-48(67)23-18-45)80(59)62(85)78-31-29-75(30-32-78)40-55(82)68-27-28-74(9)41-56(83)77-35-33-76(34-36-77)50-24-26-54(69-38-50)71-61-70-39-52-42(2)57(43(3)81)60(84)79(58(52)72-61)49-13-11-12-14-49/h15-26,37-39,49H,10-14,27-36,40-41H2,1-9H3,(H,68,82)(H,69,70,71,72)/t64-,65+/m0/s1","IGNFCLYXCYPVEB-NXURCQBISA-N"
"1427","Q00534","CDK6","MDM2","","YX-2-233","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@](C)(C2=CC=C(Cl)C=C2)[C@@](C)(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCN(C)CC(=O)N2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1182/blood.2019003604","1209.338","1207.56533261","8.47","86","10","15","2","17","194.04","C65H79Cl2N13O6","InChI=1S/C65H79Cl2N13O6/c1-10-86-53-37-46(63(4,5)6)19-25-51(53)59-73-64(7,44-15-20-47(66)21-16-44)65(8,45-17-22-48(67)23-18-45)80(59)62(85)78-31-29-75(30-32-78)40-55(82)68-27-28-74(9)41-56(83)77-35-33-76(34-36-77)50-24-26-54(69-38-50)71-61-70-39-52-42(2)57(43(3)81)60(84)79(58(52)72-61)49-13-11-12-14-49/h15-26,37-39,49H,10-14,27-36,40-41H2,1-9H3,(H,68,82)(H,69,70,71,72)/t64-,65+/m0/s1","IGNFCLYXCYPVEB-NXURCQBISA-N"
"1428","P11802","CDK4","CRBN","","AC-2-011","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCNC(=O)COC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","108","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","835.873","835.336584536","2.69","61","8","14","3","13","196.88","C42H43F2N11O6","InChI=1S/C42H43F2N11O6/c1-23(2)54-24(3)48-38-28(43)17-26(18-31(38)54)37-29(44)20-47-42(51-37)49-33-9-7-25(19-46-33)21-53-15-13-52(14-16-53)12-11-45-35(57)22-61-32-6-4-5-27-36(32)41(60)55(40(27)59)30-8-10-34(56)50-39(30)58/h4-7,9,17-20,23,30H,8,10-16,21-22H2,1-3H3,(H,45,57)(H,50,56,58)(H,46,47,49,51)","PGCGKHXKSFRMSG-UHFFFAOYSA-N"
"1428","Q00534","CDK6","CRBN","","AC-2-011","CC1=NC2=C(F)C=C(C3=NC(NC4=CC=C(CN5CCN(CCNC(=O)COC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=N4)=NC=C3F)C=C2N1C(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","108","Reduce S phase in BV173 cells","","","","","","","","","","","","","","","10.1182/blood.2019003604","835.873","835.336584536","2.69","61","8","14","3","13","196.88","C42H43F2N11O6","InChI=1S/C42H43F2N11O6/c1-23(2)54-24(3)48-38-28(43)17-26(18-31(38)54)37-29(44)20-47-42(51-37)49-33-9-7-25(19-46-33)21-53-15-13-52(14-16-53)12-11-45-35(57)22-61-32-6-4-5-27-36(32)41(60)55(40(27)59)30-8-10-34(56)50-39(30)58/h4-7,9,17-20,23,30H,8,10-16,21-22H2,1-3H3,(H,45,57)(H,50,56,58)(H,46,47,49,51)","PGCGKHXKSFRMSG-UHFFFAOYSA-N"
"1429","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCCOC3=CC=C(N4C(=O)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/51-70","Degradation of AR in LNCaP/VCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","1004.142","1003.41253216","6.85","71","6","12","3","21","203.73","C51H60F3N7O9S","InChI=1S/C51H60F3N7O9S/c1-32-43(71-31-57-32)34-13-11-33(12-14-34)28-56-45(64)41-26-38(62)29-59(41)46(65)44(49(2,3)4)58-42(63)30-69-23-10-22-68-21-8-7-9-24-70-39-19-17-36(18-20-39)61-48(67)60(47(66)50(61,5)6)37-16-15-35(27-55)40(25-37)51(52,53)54/h11-20,25,31,38,41,44,62H,7-10,21-24,26,28-30H2,1-6H3,(H,56,64)(H,58,63)/t38-,41+,44-/m1/s1","JAJUSXSEHHKCEK-UMWCMSNQSA-N"
"1430","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCN3CCC(C4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","<=501","51-70","Degradation of AR in LNCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","1045.264","1044.42132302","6.98","73","7","12","3","18","180.67","C53H63F3N8O7S2","InChI=1S/C53H63F3N8O7S2/c1-33-45(73-32-59-33)37-10-8-34(9-11-37)29-58-47(67)43-27-41(65)30-62(43)48(68)46(51(2,3)4)60-44(66)31-71-24-7-23-70-25-22-61-20-18-36(19-21-61)35-12-15-39(16-13-35)64-50(72)63(49(69)52(64,5)6)40-17-14-38(28-57)42(26-40)53(54,55)56/h8-17,26,32,36,41,43,46,65H,7,18-25,27,29-31H2,1-6H3,(H,58,67)(H,60,66)/t41-,43+,46-/m1/s1","FDBSHOXCSNLRGD-LASKKICZSA-N"
"1431","P10275","AR","VHL","","","CC(C)(C)[C@H](NC(=O)COCCCCCOC1=CC=C(C(=O)N[C@H]2C(C)(C)[C@H](OC3=CC=C(C#N)C(Cl)=C3)C2(C)C)C=C1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=CN=CS2)C=C1","<=50",">=71","Degradation of AR in LNCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","941.592","940.396011592","8.11","66","6","11","4","19","192.21","C50H61ClN6O8S","InChI=1S/C50H61ClN6O8S/c1-48(2,3)42(45(62)57-28-35(58)23-39(57)44(61)54-26-31-11-13-32(14-12-31)40-27-53-30-66-40)55-41(59)29-63-21-9-8-10-22-64-36-18-15-33(16-19-36)43(60)56-46-49(4,5)47(50(46,6)7)65-37-20-17-34(25-52)38(51)24-37/h11-20,24,27,30,35,39,42,46-47,58H,8-10,21-23,26,28-29H2,1-7H3,(H,54,61)(H,55,59)(H,56,60)/t35-,39+,42-,46-,47-/m1/s1","AMPBLCGZRAITTM-RRMXYVBQSA-N"
"1432","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCNC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(Cl)=C5)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","<=50",">=71","Degradation of AR in LNCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","968.662","967.443296132","8.92","68","6","11","5","19","195.01","C52H66ClN7O7S","InChI=1S/C52H66ClN7O7S/c1-31(33-13-15-34(16-14-33)43-32(2)56-30-68-43)57-46(64)41-25-38(61)28-60(41)47(65)44(50(3,4)5)58-42(62)29-66-24-12-10-11-23-55-37-20-17-35(18-21-37)45(63)59-48-51(6,7)49(52(48,8)9)67-39-22-19-36(27-54)40(53)26-39/h13-22,26,30-31,38,41,44,48-49,55,61H,10-12,23-25,28-29H2,1-9H3,(H,57,64)(H,58,62)(H,59,63)/t31-,38+,41-,44+,48-,49-/m0/s1","JQTRUKZGCBXQDD-IWHLCMBKSA-N"
"1433","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCC3=CC=C(C4=CC=C(C(=O)N[C@H]5C(C)(C)[C@H](OC6=CC=C(C#N)C(Cl)=C6)C5(C)C)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","<=50",">=71","Degradation of AR in LNCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","973.637","972.401096972","9.35","69","7","10","4","16","182.98","C54H61ClN6O7S","InChI=1S/C54H61ClN6O7S/c1-32-45(69-31-58-32)37-15-11-34(12-16-37)28-57-48(65)43-25-40(62)29-61(43)49(66)46(52(2,3)4)59-44(63)30-67-24-23-33-9-13-35(14-10-33)36-17-19-38(20-18-36)47(64)60-50-53(5,6)51(54(50,7)8)68-41-22-21-39(27-56)42(55)26-41/h9-22,26,31,40,43,46,50-51,62H,23-25,28-30H2,1-8H3,(H,57,65)(H,59,63)(H,60,64)/t40-,43+,46-,50-,51-/m1/s1","GPLDNHBAUYMIMT-XUDCYVGASA-N"
"1434","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC3=CC=C(OC(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(Cl)=C5)C4(C)C)C=C3)C(C)(C)C)C=C2)OC=N1","<=50",">=71","Degradation of AR in LNCaP cells after 2-4 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00115","883.443","882.37190502","6.95","63","6","11","4","14","205.35","C47H55ClN6O9","InChI=1S/C47H55ClN6O9/c1-27-38(61-26-51-27)30-13-9-28(10-14-30)22-50-40(57)36-19-32(55)23-54(36)41(58)39(45(2,3)4)52-37(56)25-60-24-29-11-16-33(17-12-29)63-44(59)53-42-46(5,6)43(47(42,7)8)62-34-18-15-31(21-49)35(48)20-34/h9-18,20,26,32,36,39,42-43,55H,19,22-25H2,1-8H3,(H,50,57)(H,52,56)(H,53,59)/t32-,36+,39-,42-,43-/m1/s1","VEFDAFDSPLDCMS-RCOCDALESA-N"
"1435","P10636","Tau","CRBN","","","O=C(CCC1=CC=C2C(=C1)[NH]C1=CC=NC=C12)NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fncel.2022.801179","582.617","582.22268268","2.11","43","6","8","4","11","162.59","C31H30N6O6","InChI=1S/C31H30N6O6/c38-26(8-5-18-4-6-19-21-17-32-11-10-22(21)35-24(19)16-18)34-13-15-43-14-12-33-23-3-1-2-20-28(23)31(42)37(30(20)41)25-7-9-27(39)36-29(25)40/h1-4,6,10-11,16-17,25,33,35H,5,7-9,12-15H2,(H,34,38)(H,36,39,40)","UPGAGRPHBZAYPF-UHFFFAOYSA-N"
"1436","P10636","Tau","CRBN","","","O=C(CCC1=CC=C2C(=C1)[NH]C1=CC=NC=C12)NCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fncel.2022.801179","670.723","670.275112176","1.82","49","6","10","4","17","181.05","C35H38N6O8","InChI=1S/C35H38N6O8/c42-30(8-5-22-4-6-23-25-21-36-11-10-26(25)39-28(23)20-22)38-13-15-48-17-19-49-18-16-47-14-12-37-27-3-1-2-24-32(27)35(46)41(34(24)45)29-7-9-31(43)40-33(29)44/h1-4,6,10-11,20-21,29,37,39H,5,7-9,12-19H2,(H,38,42)(H,40,43,44)","GEDCNVZETKRDEH-UHFFFAOYSA-N"
"1437","P10636","Tau","CRBN","","","O=C(CCC1=CC=C2C(=C1)[NH]C1=CC=NC=C12)NCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fncel.2022.801179","758.829","758.327541672","1.52","55","6","12","4","23","199.51","C39H46N6O10","InChI=1S/C39H46N6O10/c46-34(8-5-26-4-6-27-29-25-40-11-10-30(29)43-32(27)24-26)42-13-15-52-17-19-54-21-23-55-22-20-53-18-16-51-14-12-41-31-3-1-2-28-36(31)39(50)45(38(28)49)33-7-9-35(47)44-37(33)48/h1-4,6,10-11,24-25,33,41,43H,5,7-9,12-23H2,(H,42,46)(H,44,47,48)","SSTPDHWYGNBSTG-UHFFFAOYSA-N"
"1438","P10636","Tau","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCNC(=O)CCC3=CC=C4C(=C3)[NH]C3=CC=NC=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fncel.2022.801179","870.086","869.414582848","3.8","62","6","11","5","21","197.1","C46H59N7O8S","InChI=1S/C46H59N7O8S/c1-29(32-8-10-33(11-9-32)42-30(2)49-28-62-42)50-44(57)39-25-34(54)27-53(39)45(58)43(46(3,4)5)52-41(56)15-18-59-20-22-61-23-21-60-19-17-48-40(55)13-7-31-6-12-35-36-26-47-16-14-37(36)51-38(35)24-31/h6,8-12,14,16,24,26,28-29,34,39,43,51,54H,7,13,15,17-23,25,27H2,1-5H3,(H,48,55)(H,50,57)(H,52,56)/t29-,34+,39-,43+/m0/s1","GYZYGOGAACVEIQ-VQPBIZFXSA-N"
"1439","P10636","Tau","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCNC(=O)CCC3=CC=C4C(=C3)[NH]C3=CC=NC=C34)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fncel.2022.801179","958.192","957.467012344","3.51","68","6","13","5","27","215.56","C50H67N7O10S","InChI=1S/C50H67N7O10S/c1-33(36-8-10-37(11-9-36)46-34(2)53-32-68-46)54-48(61)43-29-38(58)31-57(43)49(62)47(50(3,4)5)56-45(60)15-18-63-20-22-65-24-26-67-27-25-66-23-21-64-19-17-52-44(59)13-7-35-6-12-39-40-30-51-16-14-41(40)55-42(39)28-35/h6,8-12,14,16,28,30,32-33,38,43,47,55,58H,7,13,15,17-27,29,31H2,1-5H3,(H,52,59)(H,54,61)(H,56,60)/t33-,38+,43-,47+/m0/s1","LBRDAKDQKOYPTH-BJKIJGRPSA-N"
"1440","O60885","BRD4","CRBN","","Degronimer 1","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCCCCN1CCN(C3=CC=C(NC4CCC(=O)NC4=O)C=C3)CC1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","<10000","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00042","798.458","797.360235204","6.64","56","7","11","3","15","136.85","C42H52ClN9O3S","InChI=1S/C42H52ClN9O3S/c1-27-28(2)56-42-38(27)39(30-10-12-31(43)13-11-30)46-35(40-49-48-29(3)52(40)42)26-37(54)44-20-8-6-4-5-7-9-21-50-22-24-51(25-23-50)33-16-14-32(15-17-33)45-34-18-19-36(53)47-41(34)55/h10-17,34-35,45H,4-9,18-26H2,1-3H3,(H,44,54)(H,47,53,55)/t34?,35-/m0/s1","KAFZWFVFEFZAKD-HTIIIDOHSA-N"
"1441","O60885","BRD4","CRBN","","Degronimer 2","CC1=NN=C2N1C1=CC=C(C3=CN(CCCCCCN4CCN(C5=CC=C(NC6CCC(=O)NC6=O)C=C5)CC4)N=C3)C=C1C(C1=CC=C(Cl)C=C1)=NC21CC1","","","","","","","","","","","","","","","","","","","","","","","","","","<10000","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00042","771.37","770.357198424","5.72","56","9","11","2","12","125.57","C43H47ClN10O2","InChI=1S/C43H47ClN10O2/c1-29-49-50-42-43(18-19-43)48-40(30-6-9-33(44)10-7-30)36-26-31(8-16-38(36)54(29)42)32-27-45-53(28-32)21-5-3-2-4-20-51-22-24-52(25-23-51)35-13-11-34(12-14-35)46-37-15-17-39(55)47-41(37)56/h6-14,16,26-28,37,46H,2-5,15,17-25H2,1H3,(H,47,55,56)","CYZNLZCEQIHJMZ-UHFFFAOYSA-N"
"1442","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(OCCCCCOCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00424","798.337","797.319141176","7.18","57","6","10","3","17","176.16","C43H48ClN5O8","InChI=1S/C43H48ClN5O8/c1-42(2)40(43(3,4)41(42)57-29-17-14-27(25-45)31(44)24-29)48-36(51)26-12-15-28(16-13-26)56-23-7-5-6-21-55-22-9-20-46-32-11-8-10-30-35(32)39(54)49(38(30)53)33-18-19-34(50)47-37(33)52/h8,10-17,24,33,40-41,46H,5-7,9,18-23H2,1-4H3,(H,48,51)(H,47,50,52)/t33?,40-,41-","QSPCDHGSGMVDJL-IVBVVVCDSA-N"
"1443","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2=CC=C(OCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00424","822.866","822.244738564","7.33","59","7","9","2","12","152.15","C43H37F3N6O6S","InChI=1S/C43H37F3N6O6S/c1-42(2)40(57)50(29-16-11-27(24-47)32(23-29)43(44,45)46)41(59)52(42)28-14-9-25(10-15-28)26-12-17-30(18-13-26)58-22-5-3-4-21-48-33-8-6-7-31-36(33)39(56)51(38(31)55)34-19-20-35(53)49-37(34)54/h6-18,23,34,48H,3-5,19-22H2,1-2H3,(H,49,53,54)","LTNVQSMHVCBXCG-UHFFFAOYSA-N"
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"1451","Q9NWZ3","IRAK4","CRBN","","","NCC1=NN(C2=CC=C(C(=O)NCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C=C1NC(=O)C1=COC(C2=CC=NC(NCC(F)(F)F)=C2)=N1","","","",">50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","887.833","887.29625652","2.36","64","7","16","6","19","267.03","C41H40F3N11O9","InChI=1S/C41H40F3N11O9/c42-41(43,44)22-49-32-18-24(10-11-47-32)38-51-30(21-64-38)36(58)50-29-20-54(53-28(29)19-45)25-6-4-23(5-7-25)35(57)48-13-15-63-17-16-62-14-12-46-27-3-1-2-26-34(27)40(61)55(39(26)60)31-8-9-33(56)52-37(31)59/h1-7,10-11,18,20-21,31,46H,8-9,12-17,19,22,45H2,(H,47,49)(H,48,57)(H,50,58)(H,52,56,59)","GMSYMVWHCWNMPW-UHFFFAOYSA-N"
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"1456","Q9NWZ3","IRAK4","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC4CCN(CCOCCOCCNC(=O)C5=CC=C(N6C=C(NC(=O)C7=COC(C8=CC=NC(NCC(F)(F)F)=C8)=N7)C(C(F)F)=N6)C=C5)CC4)=C3C2=O)C(=O)N1","","","",">50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","991.932","991.340013152","4.16","71","8","16","5","20","244.25","C46H46F5N11O9","InChI=1S/C46H46F5N11O9/c47-39(48)38-32(56-41(65)33-24-71-43(57-33)27-10-13-52-35(22-27)54-25-46(49,50)51)23-61(59-38)29-6-4-26(5-7-29)40(64)53-14-18-69-20-21-70-19-17-60-15-11-28(12-16-60)55-31-3-1-2-30-37(31)45(68)62(44(30)67)34-8-9-36(63)58-42(34)66/h1-7,10,13,22-24,28,34,39,55H,8-9,11-12,14-21,25H2,(H,52,54)(H,53,64)(H,56,65)(H,58,63,66)","NEDLOBIINPJVJR-UHFFFAOYSA-N"
"1457","Q9NWZ3","IRAK4","CRBN","","","NC(=O)C1=NN(C2=CC=C(CNCC3CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CCO3)C=C2)C=C1NC(=O)C1=COC(C2=CC=NC(NCC(F)(F)F)=C2)=N1","","","",">50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","942.913","942.33845568","2.65","68","8","17","6","19","270.27","C44H45F3N12O9","InChI=1S/C44H45F3N12O9/c45-44(46,47)24-52-34-18-26(10-11-51-34)41-54-32(23-68-41)39(62)53-31-22-58(56-37(31)38(48)61)27-6-4-25(5-7-27)19-49-20-28-21-57(14-17-67-28)13-16-66-15-12-50-30-3-1-2-29-36(30)43(65)59(42(29)64)33-8-9-35(60)55-40(33)63/h1-7,10-11,18,22-23,28,33,49-50H,8-9,12-17,19-21,24H2,(H2,48,61)(H,51,52)(H,53,62)(H,55,60,63)","LHRPSSVRMZOELN-UHFFFAOYSA-N"
"1458","Q9NWZ3","IRAK4","CRBN","","","CN(CCOCCOCCCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1)CC1=CC=C(N2C=C(NC(=O)C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)C(C(N)=O)=N2)C=C1","","","","20-50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","872.94","872.360573116","2.95","64","8","15","4","21","246.21","C45H48N10O9","InChI=1S/C45H48N10O9/c1-53(16-18-63-20-19-62-17-2-3-27-8-11-32-33(21-27)45(61)55(44(32)60)36-12-13-38(56)51-42(36)59)24-29-6-9-31(10-7-29)54-25-34(39(52-54)40(46)57)49-41(58)35-26-64-43(50-35)30-14-15-47-37(22-30)48-23-28-4-5-28/h6-11,14-15,21-22,25-26,28,36H,2-5,12-13,16-20,23-24H2,1H3,(H2,46,57)(H,47,48)(H,49,58)(H,51,56,59)","QHTRGRVSPWMPCL-UHFFFAOYSA-N"
"1459","Q9NWZ3","IRAK4","CRBN","","","CN(CCOCCOCCCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1)CC1=CC=C(N2C=C(NC(=O)C3=COC(C4=CC=NC=C4)=N3)C(C(N)=O)=N2)C=C1","","","","20-50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","803.833","803.302723892","1.89","59","7","14","3","18","234.18","C41H41N9O9","InChI=1S/C41H41N9O9/c1-48(16-18-58-20-19-57-17-2-3-25-6-9-29-30(21-25)41(56)50(40(29)55)33-10-11-34(51)46-38(33)54)22-26-4-7-28(8-5-26)49-23-31(35(47-49)36(42)52)44-37(53)32-24-59-39(45-32)27-12-14-43-15-13-27/h4-9,12-15,21,23-24,33H,2-3,10-11,16-20,22H2,1H3,(H2,42,52)(H,44,53)(H,46,51,54)","NDFHKKBPNSXZOS-UHFFFAOYSA-N"
"1460","Q9NWZ3","IRAK4","CRBN","","","CN(CCOCCCC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1=CC=C(N2C=C(NC(=O)C3=COC(C4=CC=NC(NCC5CC5)=C4)=N3)C(C(N)=O)=N2)C=C1","","","","20-50/>50/>50","% IRAK4 degradation in OCILY-10 cells after 4 h treatment at 10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00423","828.887","828.334358368","3.1","61","8","14","4","18","236.98","C43H44N10O8","InChI=1S/C43H44N10O8/c1-51(17-19-60-18-3-5-27-4-2-6-30-36(27)43(59)53(42(30)58)33-13-14-35(54)49-40(33)57)22-26-9-11-29(12-10-26)52-23-31(37(50-52)38(44)55)47-39(56)32-24-61-41(48-32)28-15-16-45-34(20-28)46-21-25-7-8-25/h2,4,6,9-12,15-16,20,23-25,33H,3,5,7-8,13-14,17-19,21-22H2,1H3,(H2,44,55)(H,45,46)(H,47,56)(H,49,54,57)","XTPZACBHGSKXJI-UHFFFAOYSA-N"
"1461","Q9NWZ3","IRAK4","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(OCCOCCOCCN4CCN(CC5=CC=C6N=C(NC(=O)C7=CC=CC(C(F)(F)F)=C7)N([C@H]7CC[C@@H](CO)CC7)C6=C5)CC4)C=C3C2=O)C(=O)N1","<30",">70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","903.956","903.377860904","3.46","65","8","13","3","17","184.87","C46H52F3N7O9","InChI=1S/C46H52F3N7O9/c47-46(48,49)32-3-1-2-31(25-32)41(59)52-45-50-37-11-6-30(24-39(37)55(45)33-7-4-29(28-57)5-8-33)27-54-16-14-53(15-17-54)18-19-63-20-21-64-22-23-65-34-9-10-35-36(26-34)44(62)56(43(35)61)38-12-13-40(58)51-42(38)60/h1-3,6,9-11,24-26,29,33,38,57H,4-5,7-8,12-23,27-28H2,(H,50,52,59)(H,51,58,60)/t29-,33+,38?","DRSGINHARUFRQE-CDUPFHCPSA-N"
"1462","Q9NWZ3","IRAK4","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(OCCOCCOCCOCCN4CCN(CC5=CC=C6N=C(NC(=O)C7=CC=CC(C(F)(F)F)=C7)N([C@H]7CC[C@@H](CO)CC7)C6=C5)CC4)C=C3C2=O)C(=O)N1","<30",">70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","948.009","947.404075652","3.31","68","8","14","3","20","194.1","C48H56F3N7O10","InChI=1S/C48H56F3N7O10/c49-48(50,51)34-3-1-2-33(27-34)43(61)54-47-52-39-11-6-32(26-41(39)57(47)35-7-4-31(30-59)5-8-35)29-56-16-14-55(15-17-56)18-19-65-20-21-66-22-23-67-24-25-68-36-9-10-37-38(28-36)46(64)58(45(37)63)40-12-13-42(60)53-44(40)62/h1-3,6,9-11,26-28,31,35,40,59H,4-5,7-8,12-25,29-30H2,(H,52,54,61)(H,53,60,62)/t31-,35+,40?","ADNQFJRANZZPKY-RGDYMFDWSA-N"
"1463","Q9NWZ3","IRAK4","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(N4CCC(CN5CCN(CC6=CC=C7N=C(NC(=O)C8=CC=CC(C(F)(F)F)=C8)N([C@H]8CC[C@@H](CO)CC8)C7=C6)CC5)CC4)C=C3C2=O)C(=O)N1","<30",">70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","868.958","868.388366012","4.65","63","9","11","3","10","160.42","C46H51F3N8O6","InChI=1S/C46H51F3N8O6/c47-46(48,49)32-3-1-2-31(23-32)41(60)52-45-50-37-11-6-30(22-39(37)56(45)33-7-4-29(27-58)5-8-33)26-54-20-18-53(19-21-54)25-28-14-16-55(17-15-28)34-9-10-35-36(24-34)44(63)57(43(35)62)38-12-13-40(59)51-42(38)61/h1-3,6,9-11,22-24,28-29,33,38,58H,4-5,7-8,12-21,25-27H2,(H,50,52,60)(H,51,59,61)/t29-,33+,38?","RJDRFOSUZYUZBV-CDUPFHCPSA-N"
"1464","Q9NWZ3","IRAK4","CRBN","","","COC1=CC2=NN(C3CCN(CCOCCOC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)C=C2C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1","<30","50-70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","763.73","763.257745772","2.78","55","7","12","2","12","174.29","C37H36F3N7O8","InChI=1S/C37H36F3N7O8/c1-53-30-19-27-21(17-28(30)42-33(49)26-3-2-4-31(41-26)37(38,39)40)20-46(44-27)22-9-11-45(12-10-22)13-14-54-15-16-55-23-5-6-24-25(18-23)36(52)47(35(24)51)29-7-8-32(48)43-34(29)50/h2-6,17-20,22,29H,7-16H2,1H3,(H,42,49)(H,43,48,50)","XXKSDGIIEAJWCB-UHFFFAOYSA-N"
"1465","Q9NWZ3","IRAK4","CRBN","","","COC1=CC2=NN(C3CCN(CCOCCOC4=CC=C5CN(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)C=C2C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1","<30","50-70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","749.747","749.278481216","2.83","54","7","11","2","12","157.22","C37H38F3N7O7","InChI=1S/C37H38F3N7O7/c1-52-31-19-28-23(17-29(31)42-34(49)27-3-2-4-32(41-27)37(38,39)40)21-47(44-28)24-9-11-45(12-10-24)13-14-53-15-16-54-25-6-5-22-20-46(36(51)26(22)18-25)30-7-8-33(48)43-35(30)50/h2-6,17-19,21,24,30H,7-16,20H2,1H3,(H,42,49)(H,43,48,50)","KSDCGXPRMXBENQ-UHFFFAOYSA-N"
"1466","Q9NWZ3","IRAK4","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(OC4CCC(CN5CCN(CC6=CC=C7N=C(NC(=O)C8=CC=CC(C(F)(F)F)=C8)N([C@H]8CC[C@@H](CO)CC8)C7=C6)CC5)CC4)C=C3C2=O)C(=O)N1","30-100",">70","Degradation of IRAK4 in MCF7 cells","","","<30","IC50 was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00385","883.969","883.388031664","5.28","64","9","11","3","11","166.41","C47H52F3N7O7","InChI=1S/C47H52F3N7O7/c48-47(49,50)32-3-1-2-31(23-32)42(60)53-46-51-38-15-8-30(22-40(38)56(46)33-9-4-29(27-58)5-10-33)26-55-20-18-54(19-21-55)25-28-6-11-34(12-7-28)64-35-13-14-36-37(24-35)45(63)57(44(36)62)39-16-17-41(59)52-43(39)61/h1-3,8,13-15,22-24,28-29,33-34,39,58H,4-7,9-12,16-21,25-27H2,(H,51,53,60)(H,52,59,61)/t28?,29-,33+,34?,39?","LGAMKMQUDXCHFO-RIOIAMSCSA-N"
"1467","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.3","","Degradation of ERalpha in MCF7 cells","","","0.8","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","1005.214","1004.46931876","7.29","71","7","11","4","21","167.58","C53H67F3N6O8S","InChI=1S/C53H67F3N6O8S/c1-31-23-39-38-11-9-10-12-42(38)59-46(39)47(62(31)29-53(7,8)56)45-40(54)25-37(26-41(45)55)70-22-21-68-18-17-67-19-20-69-28-44(64)60-49(52(4,5)6)51(66)61-27-36(63)24-43(61)50(65)58-32(2)34-13-15-35(16-14-34)48-33(3)57-30-71-48/h9-16,25-26,30-32,36,43,47,49,59,63H,17-24,27-29H2,1-8H3,(H,58,65)(H,60,64)/t31-,32+,36-,43+,47-,49-/m1/s1","WNWBHGDKGOSOKU-QIINAUKOSA-N"
"1468","P03372","ER","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.4","","Degradation of ERalpha in MCF7 cells","","","0.5","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","961.161","960.443104016","7.39","68","7","10","4","19","158.35","C51H63F3N6O7S","InChI=1S/C51H63F3N6O7S/c1-30-21-37-36-11-8-9-12-40(36)57-44(37)45(60(30)28-51(6,7)54)43-38(52)23-35(24-39(43)53)67-20-19-65-17-10-18-66-27-42(62)58-47(50(3,4)5)49(64)59-26-34(61)22-41(59)48(63)55-25-32-13-15-33(16-14-32)46-31(2)56-29-68-46/h8-9,11-16,23-24,29-30,34,41,45,47,57,61H,10,17-22,25-28H2,1-7H3,(H,55,63)(H,58,62)/t30-,34-,41+,45-,47-/m1/s1","WNJYGPJDJPCRJH-GSXDKGEZSA-N"
"1469","P03372","ER","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.3","","Degradation of ERalpha in MCF7 cells","","","0.7","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","991.187","990.4536687","6.89","70","7","11","4","21","167.58","C52H65F3N6O8S","InChI=1S/C52H65F3N6O8S/c1-31-22-38-37-10-8-9-11-41(37)58-45(38)46(61(31)29-52(6,7)55)44-39(53)24-36(25-40(44)54)69-21-20-67-17-16-66-18-19-68-28-43(63)59-48(51(3,4)5)50(65)60-27-35(62)23-42(60)49(64)56-26-33-12-14-34(15-13-33)47-32(2)57-30-70-47/h8-15,24-25,30-31,35,42,46,48,58,62H,16-23,26-29H2,1-7H3,(H,56,64)(H,59,63)/t31-,35-,42+,46-,48-/m1/s1","WWSBSFVKXFRDJO-DXALMRNBSA-N"
"1470","P03372","ER","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.4","","Degradation of ERalpha in MCF7 cells","","","0.6","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","975.188","974.45875408","7.75","69","7","10","4","20","158.35","C52H65F3N6O7S","InChI=1S/C52H65F3N6O7S/c1-31-22-38-37-12-8-9-13-41(37)58-45(38)46(61(31)29-52(6,7)55)44-39(53)24-36(25-40(44)54)68-21-11-19-66-18-10-20-67-28-43(63)59-48(51(3,4)5)50(65)60-27-35(62)23-42(60)49(64)56-26-33-14-16-34(17-15-33)47-32(2)57-30-69-47/h8-9,12-17,24-25,30-31,35,42,46,48,58,62H,10-11,18-23,26-29H2,1-7H3,(H,56,64)(H,59,63)/t31-,35-,42+,46-,48-/m1/s1","PMXVLCRRMGVGJX-DXALMRNBSA-N"
"1471","P03372","ER","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCC(F)(F)CCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.8","","Degradation of ERalpha in MCF7 cells","","","0.5","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","1025.195","1024.45556052","8.42","72","7","10","4","21","158.35","C53H65F5N6O7S","InChI=1S/C53H65F5N6O7S/c1-31-22-38-37-10-8-9-11-41(37)61-45(38)46(64(31)29-52(6,7)56)44-39(54)24-36(25-40(44)55)71-19-17-53(57,58)16-18-69-20-21-70-28-43(66)62-48(51(3,4)5)50(68)63-27-35(65)23-42(63)49(67)59-26-33-12-14-34(15-13-33)47-32(2)60-30-72-47/h8-15,24-25,30-31,35,42,46,48,61,65H,16-23,26-29H2,1-7H3,(H,59,67)(H,62,66)/t31-,35-,42+,46-,48-/m1/s1","KEOMTDRIBPAOQE-DXALMRNBSA-N"
"1472","P03372","ER","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCCCCOC3=CC(F)=C([C@@H]4C5=C(C[C@@H](C)N4CC(C)(C)F)C4=CC=CC=C4[NH]5)C(F)=C3)C(C)(C)C)C=C2)SC=N1","0.6","","Degradation of ERalpha in MCF7 cells","","","0.5","IC50 of ERalpha was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00397","1003.242","1002.49005421","8.51","71","7","10","4","21","158.35","C54H69F3N6O7S","InChI=1S/C54H69F3N6O7S/c1-32-24-40-39-14-10-11-15-43(39)60-47(40)48(63(32)30-54(7,8)57)46-41(55)26-38(27-42(46)56)70-21-13-9-12-20-68-22-23-69-29-45(65)61-50(53(4,5)6)52(67)62-28-37(64)25-44(62)51(66)59-33(2)35-16-18-36(19-17-35)49-34(3)58-31-71-49/h10-11,14-19,26-27,31-33,37,44,48,50,60,64H,9,12-13,20-25,28-30H2,1-8H3,(H,59,66)(H,61,65)/t32-,33+,37-,44+,48-,50-/m1/s1","KCIXKNDPNDCWMB-GXXILBQTSA-N"
"1473","P00533","EGFR","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<500","Inhibit proliferation of T790M/L858R transformed Ba/F3 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00283","969.09","968.352710864","3.86","70","9","14","3","20","209.12","C51H52N8O10S","InChI=1S/C51H52N8O10S/c60-42-16-15-41(46(62)54-42)59-49(65)38-7-4-8-40(44(38)50(59)66)52-18-25-68-27-29-69-28-26-67-24-17-43(61)57-22-20-56(21-23-57)37-13-11-33(12-14-37)35-9-10-36-32-58(48(64)39(36)31-35)45(34-5-2-1-3-6-34)47(63)55-51-53-19-30-70-51/h1-14,19,30-31,41,45,52H,15-18,20-29,32H2,(H,53,55,63)(H,54,60,62)","YQIWOKJOFFNGOJ-UHFFFAOYSA-N"
"1473","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","126","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","969.09","968.352710864","3.86","70","9","14","3","20","209.12","C51H52N8O10S","InChI=1S/C51H52N8O10S/c60-42-16-15-41(46(62)54-42)59-49(65)38-7-4-8-40(44(38)50(59)66)52-18-25-68-27-29-69-28-26-67-24-17-43(61)57-22-20-56(21-23-57)37-13-11-33(12-14-37)35-9-10-36-32-58(48(64)39(36)31-35)45(34-5-2-1-3-6-34)47(63)55-51-53-19-30-70-51/h1-14,19,30-31,41,45,52H,15-18,20-29,32H2,(H,53,55,63)(H,54,60,62)","YQIWOKJOFFNGOJ-UHFFFAOYSA-N"
"1474","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","161","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","941.08","940.357796244","4.47","68","9","14","3","20","192.05","C50H52N8O9S","InChI=1S/C50H52N8O9S/c59-42-16-15-41(45(60)53-42)58-48(63)38-7-4-8-40(43(38)49(58)64)51-17-24-65-26-28-67-29-27-66-25-23-55-19-21-56(22-20-55)37-13-11-33(12-14-37)35-9-10-36-32-57(47(62)39(36)31-35)44(34-5-2-1-3-6-34)46(61)54-50-52-18-30-68-50/h1-14,18,30-31,41,44,51H,15-17,19-29,32H2,(H,52,54,61)(H,53,59,60)","DXDCJEWJBVJABL-UHFFFAOYSA-N"
"1475","P00533","EGFR","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<500","Inhibit proliferation of T790M/L858R transformed Ba/F3 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00283","985.133","984.384010992","4.32","71","9","15","3","23","201.28","C52H56N8O10S","InChI=1S/C52H56N8O10S/c61-44-16-15-43(47(62)55-44)60-50(65)40-7-4-8-42(45(40)51(60)66)53-17-24-67-26-28-69-30-31-70-29-27-68-25-23-57-19-21-58(22-20-57)39-13-11-35(12-14-39)37-9-10-38-34-59(49(64)41(38)33-37)46(36-5-2-1-3-6-36)48(63)56-52-54-18-32-71-52/h1-14,18,32-33,43,46,53H,15-17,19-31,34H2,(H,54,56,63)(H,55,61,62)","LWCGWAABACSQFJ-UHFFFAOYSA-N"
"1476","P00533","EGFR L858R/T790M","CRBN","","DDC-01-163","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)=C3C2=O)C(=O)N1","","","","","","45","IC50 of L858R/T790M EGFR was assessed using HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","10.1002/anie.202003500","942.068","941.353045212","3.73","68","9","15","3","20","204.94","C49H51N9O9S","InChI=1S/C49H51N9O9S/c59-41-14-12-39(44(60)53-41)58-47(63)36-7-4-8-38(42(36)48(58)64)50-15-22-65-24-26-67-27-25-66-23-21-55-17-19-56(20-18-55)40-13-11-34(30-52-40)33-9-10-35-31-57(46(62)37(35)29-33)43(32-5-2-1-3-6-32)45(61)54-49-51-16-28-68-49/h1-11,13,16,28-30,39,43,50H,12,14-15,17-27,31H2,(H,51,54,61)(H,53,59,60)","QVOJDGYNXIRHHU-UHFFFAOYSA-N"
"1476","P00533","EGFR L858R/T790M/C797S","CRBN","","DDC-01-163","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41","Inhibit proliferation of L858R/T790M/C797S EGFR-Ba/F3 cells","","","","","","","","","","","","","10.1002/anie.202003500","942.068","941.353045212","3.73","68","9","15","3","20","204.94","C49H51N9O9S","InChI=1S/C49H51N9O9S/c59-41-14-12-39(44(60)53-41)58-47(63)36-7-4-8-38(42(36)48(58)64)50-15-22-65-24-26-67-27-25-66-23-21-55-17-19-56(20-18-55)40-13-11-34(30-52-40)33-9-10-35-31-57(46(62)37(35)29-33)43(32-5-2-1-3-6-32)45(61)54-49-51-16-28-68-49/h1-11,13,16,28-30,39,43,50H,12,14-15,17-27,31H2,(H,51,54,61)(H,53,59,60)","QVOJDGYNXIRHHU-UHFFFAOYSA-N"
"1476","P00533","EGFR L858R/T790M/L718Q","CRBN","","DDC-01-163","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28","Inhibit proliferation of L858R/T790M/L718Q EGFR-Ba/F3 cells","","","","","","","","","","","","","10.1002/anie.202003500","942.068","941.353045212","3.73","68","9","15","3","20","204.94","C49H51N9O9S","InChI=1S/C49H51N9O9S/c59-41-14-12-39(44(60)53-41)58-47(63)36-7-4-8-38(42(36)48(58)64)50-15-22-65-24-26-67-27-25-66-23-21-55-17-19-56(20-18-55)40-13-11-34(30-52-40)33-9-10-35-31-57(46(62)37(35)29-33)43(32-5-2-1-3-6-32)45(61)54-49-51-16-28-68-49/h1-11,13,16,28-30,39,43,50H,12,14-15,17-27,31H2,(H,51,54,61)(H,53,59,60)","QVOJDGYNXIRHHU-UHFFFAOYSA-N"
"1477","Q9UM73","ALK","CRBN","","CZ40-53","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CC(=O)NCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00296","1090.698","1089.4396673","6.07","76","7","18","5","28","258.05","C53H68ClN9O12S","InChI=1S/C53H68ClN9O12S/c1-33(2)75-44-30-38(35(5)29-42(44)59-53-57-31-39(54)49(61-53)58-40-10-6-7-12-45(40)76(69,70)34(3)4)36-15-19-62(20-16-36)32-47(65)56-18-22-72-24-26-74-28-27-73-25-23-71-21-17-55-41-11-8-9-37-48(41)52(68)63(51(37)67)43-13-14-46(64)60-50(43)66/h6-12,29-31,33-34,36,43,55H,13-28,32H2,1-5H3,(H,56,65)(H,60,64,66)(H2,57,58,59,61)","QTBMHRVZWBBKIB-UHFFFAOYSA-N"
"1478","Q9UM73","ALK","VHL","","HC58-98","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(C(=O)COCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00296","1144.859","1143.46885925","8.59","79","7","16","5","22","243.61","C57H74ClN9O10S2","InChI=1S/C57H74ClN9O10S2/c1-33(2)77-47-27-42(35(5)25-45(47)63-56-59-28-43(58)53(65-56)62-44-13-11-12-14-48(44)79(73,74)34(3)4)39-19-21-66(22-20-39)50(70)31-76-24-23-75-30-49(69)64-52(57(8,9)10)55(72)67-29-41(68)26-46(67)54(71)61-36(6)38-15-17-40(18-16-38)51-37(7)60-32-78-51/h11-18,25,27-28,32-34,36,39,41,46,52,68H,19-24,26,29-31H2,1-10H3,(H,61,71)(H,64,69)(H2,59,62,63,65)/t36-,41+,46-,52+/m0/s1","WIVMQRFHGMKBNK-FFXVWJLRSA-N"
"1479","Q9UM73","ALK","VHL","","HC58-99","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(C(=O)CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00296","1098.834","1097.46337994","9.05","76","7","14","5","19","225.15","C56H72ClN9O8S2","InChI=1S/C56H72ClN9O8S2/c1-32(2)74-46-28-41(34(5)26-44(46)62-55-58-29-42(57)52(64-55)61-43-14-11-12-15-47(43)76(72,73)33(3)4)38-22-24-65(25-23-38)49(69)17-13-16-48(68)63-51(56(8,9)10)54(71)66-30-40(67)27-45(66)53(70)60-35(6)37-18-20-39(21-19-37)50-36(7)59-31-75-50/h11-12,14-15,18-21,26,28-29,31-33,35,38,40,45,51,67H,13,16-17,22-25,27,30H2,1-10H3,(H,60,70)(H,63,68)(H2,58,61,62,64)/t35-,40+,45-,51+/m0/s1","OLQKKOBOIAQEBA-RJKOKIJFSA-N"
"1480","P01116","KRAS","VHL","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/>=50/>=50","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","1223.867","1222.50883015","7.33","86","8","17","5","27","250.45","C62H76ClFN10O11S","InChI=1S/C62H76ClFN10O11S/c1-8-51(78)72-19-21-73(22-20-72)58-47-34-48(63)53(46-32-43(75)31-42-11-9-10-12-45(42)46)54(64)55(47)69-61(70-58)65-18-17-52(79)71(7)23-24-82-25-26-83-27-28-84-29-30-85-36-50(77)68-57(62(4,5)6)60(81)74-35-44(76)33-49(74)59(80)67-38(2)40-13-15-41(16-14-40)56-39(3)66-37-86-56/h8-16,31-32,34,37-38,44,49,57,75-76H,1,17-30,33,35-36H2,2-7H3,(H,67,80)(H,68,77)(H,65,69,70)/t38-,44+,49-,57+/m0/s1","SZXPSAFGLXHHHB-UGZMMWHZSA-N"
"1481","P01116","KRAS","VHL","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/>=50/>=50","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","1267.92","1266.5350449","7.19","89","8","18","5","30","259.68","C64H80ClFN10O12S","InChI=1S/C64H80ClFN10O12S/c1-8-53(80)74-19-21-75(22-20-74)60-49-36-50(65)55(48-34-45(77)33-44-11-9-10-12-47(44)48)56(66)57(49)71-63(72-60)67-18-17-54(81)73(7)23-24-84-25-26-85-27-28-86-29-30-87-31-32-88-38-52(79)70-59(64(4,5)6)62(83)76-37-46(78)35-51(76)61(82)69-40(2)42-13-15-43(16-14-42)58-41(3)68-39-89-58/h8-16,33-34,36,39-40,46,51,59,77-78H,1,17-32,35,37-38H2,2-7H3,(H,69,82)(H,70,79)(H,67,71,72)/t40-,46+,51-,59+/m0/s1","FIFSEXYOESMAAZ-FWWWWKFMSA-N"
"1482","P01116","KRAS","CRBN","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/25-50/25-50","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","994.478","993.358794796","5.4","71","8","15","4","21","225.17","C50H53ClFN9O10","InChI=1S/C50H53ClFN9O10/c1-3-40(64)59-16-18-60(19-17-59)46-35-29-36(51)42(34-28-31(62)27-30-7-4-5-8-32(30)34)44(52)45(35)56-50(57-46)54-14-13-41(65)58(2)20-22-70-24-26-71-25-23-69-21-15-53-37-10-6-9-33-43(37)49(68)61(48(33)67)38-11-12-39(63)55-47(38)66/h3-10,27-29,38,53,62H,1,11-26H2,2H3,(H,54,56,57)(H,55,63,66)","LBWOFJWPPVDIKM-UHFFFAOYSA-N"
"1483","P01116","KRAS","VHL","","","C=CC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/25-50/25-50","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","1193.841","1192.49826547","7.38","84","8","16","5","25","241.22","C61H74ClFN10O10S","InChI=1S/C61H74ClFN10O10S/c1-8-50(77)71-20-22-72(23-21-71)57-46-34-47(62)52(45-32-42(74)31-41-11-9-10-12-44(41)45)53(63)54(46)68-60(69-57)64-19-17-51(78)70(7)24-26-82-28-30-83-29-27-81-25-18-49(76)67-56(61(4,5)6)59(80)73-35-43(75)33-48(73)58(79)66-37(2)39-13-15-40(16-14-39)55-38(3)65-36-84-55/h8-16,31-32,34,36-37,43,48,56,74-75H,1,17-30,33,35H2,2-7H3,(H,66,79)(H,67,76)(H,64,68,69)/t37-,43+,48-,56+/m0/s1","KYNLICKDOYXLDI-YLTIUYMNSA-N"
"1484","P01116","KRAS","CRBN","","","CCC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCOCCOC3=CC=C4C(=O)N(C5CCC(=O)NC5=O)CC4=C3)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/25-50/25-50","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","1027.548","1026.40541064","4.62","73","8","15","3","24","214.53","C52H60ClFN8O11","InChI=1S/C52H60ClFN8O11/c1-3-44(65)60-14-16-61(17-15-60)49-40-31-41(53)46(39-30-35(63)28-33-6-4-5-7-37(33)39)47(54)48(40)57-52(58-49)55-13-12-45(66)59(2)18-19-69-20-21-70-22-23-71-24-25-72-26-27-73-36-8-9-38-34(29-36)32-62(51(38)68)42-10-11-43(64)56-50(42)67/h4-9,28-31,42,63H,3,10-27,32H2,1-2H3,(H,55,57,58)(H,56,64,67)","WDEFLCUOWXEZNQ-UHFFFAOYSA-N"
"1485","P01116","KRAS","VHL","","","CCC(=O)N1CCN(C2=NC(NCCC(=O)N(C)CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C(F)C(C4=CC(O)=CC5=CC=CC=C45)=C(Cl)C=C23)CC1","","","","<25/<25/<25","% KRAS degradation in H2023 cells at 300/1000/3000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00584","1225.883","1224.52448022","7.21","86","8","17","5","27","250.45","C62H78ClFN10O11S","InChI=1S/C62H78ClFN10O11S/c1-8-51(78)72-19-21-73(22-20-72)58-47-34-48(63)53(46-32-43(75)31-42-11-9-10-12-45(42)46)54(64)55(47)69-61(70-58)65-18-17-52(79)71(7)23-24-82-25-26-83-27-28-84-29-30-85-36-50(77)68-57(62(4,5)6)60(81)74-35-44(76)33-49(74)59(80)67-38(2)40-13-15-41(16-14-40)56-39(3)66-37-86-56/h9-16,31-32,34,37-38,44,49,57,75-76H,8,17-30,33,35-36H2,1-7H3,(H,67,80)(H,68,77)(H,65,69,70)/t38-,44+,49-,57+/m0/s1","LLQQVMLZWGPUJC-UGZMMWHZSA-N"
"1486","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","4/0","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","948.617","947.370148256","4.31","65","6","14","7","15","250.89","C45H58ClN11O6S2","InChI=1S/C45H58ClN11O6S2/c1-25(27-10-12-28(13-11-27)38-26(2)51-24-64-38)52-41(62)31-20-29(58)23-57(31)43(63)39(44(3,4)5)55-34(59)14-17-49-35(60)21-36(61)53-30-8-7-9-32(37(30)46)65-42-40(47)54-33(22-50-42)56-18-15-45(6,48)16-19-56/h7-13,22,24-25,29,31,39,58H,14-21,23,48H2,1-6H3,(H2,47,54)(H,49,60)(H,52,62)(H,53,61)(H,55,59)/t25-,29+,31-,39+/m0/s1","IUEGADZTGLSZDJ-ISGKUXFXSA-N"
"1487","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","9/7","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","962.644","961.38579832","4.67","66","6","14","7","16","250.89","C46H60ClN11O6S2","InChI=1S/C46H60ClN11O6S2/c1-26(28-12-14-29(15-13-28)39-27(2)52-25-65-39)53-42(63)32-21-30(59)24-58(32)44(64)40(45(3,4)5)56-35(60)11-8-18-50-36(61)22-37(62)54-31-9-7-10-33(38(31)47)66-43-41(48)55-34(23-51-43)57-19-16-46(6,49)17-20-57/h7,9-10,12-15,23,25-26,30,32,40,59H,8,11,16-22,24,49H2,1-6H3,(H2,48,55)(H,50,61)(H,53,63)(H,54,62)(H,56,60)/t26-,30+,32-,40+/m0/s1","BSUPZQFUKPWPOE-FUEJLLDSSA-N"
"1488","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","13/6","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","976.671","975.401448384","5.03","67","6","14","7","17","250.89","C47H62ClN11O6S2","InChI=1S/C47H62ClN11O6S2/c1-27(29-13-15-30(16-14-29)40-28(2)53-26-66-40)54-43(64)33-22-31(60)25-59(33)45(65)41(46(3,4)5)57-36(61)12-7-8-19-51-37(62)23-38(63)55-32-10-9-11-34(39(32)48)67-44-42(49)56-35(24-52-44)58-20-17-47(6,50)18-21-58/h9-11,13-16,24,26-27,31,33,41,60H,7-8,12,17-23,25,50H2,1-6H3,(H2,49,56)(H,51,62)(H,54,64)(H,55,63)(H,57,61)/t27-,31+,33-,41+/m0/s1","OCFFPCZLJBIURT-TVBSSPMISA-N"
"1489","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","0/3","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","990.698","989.417098448","5.38","68","6","14","7","18","250.89","C48H64ClN11O6S2","InChI=1S/C48H64ClN11O6S2/c1-28(30-14-16-31(17-15-30)41-29(2)54-27-67-41)55-44(65)34-23-32(61)26-60(34)46(66)42(47(3,4)5)58-37(62)13-8-7-9-20-52-38(63)24-39(64)56-33-11-10-12-35(40(33)49)68-45-43(50)57-36(25-53-45)59-21-18-48(6,51)19-22-59/h10-12,14-17,25,27-28,32,34,42,61H,7-9,13,18-24,26,51H2,1-6H3,(H2,50,57)(H,52,63)(H,55,65)(H,56,64)(H,58,62)/t28-,32+,34-,42+/m0/s1","LYNHJTOOUICSOZ-ZEUHRWFYSA-N"
"1490","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","0/0","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1004.725","1003.43274851","5.93","69","6","14","7","19","250.89","C49H66ClN11O6S2","InChI=1S/C49H66ClN11O6S2/c1-29(31-15-17-32(18-16-31)42-30(2)55-28-68-42)56-45(66)35-24-33(62)27-61(35)47(67)43(48(3,4)5)59-38(63)14-9-7-8-10-21-53-39(64)25-40(65)57-34-12-11-13-36(41(34)50)69-46-44(51)58-37(26-54-46)60-22-19-49(6,52)20-23-60/h11-13,15-18,26,28-29,33,35,43,62H,7-10,14,19-25,27,52H2,1-6H3,(H2,51,58)(H,53,64)(H,56,66)(H,57,65)(H,59,63)/t29-,33+,35-,43+/m0/s1","MYBHAEJFKMYUTJ-XGCQBFBTSA-N"
"1491","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","20/14","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1018.752","1017.44839858","6.47","70","6","14","7","20","250.89","C50H68ClN11O6S2","InChI=1S/C50H68ClN11O6S2/c1-30(32-16-18-33(19-17-32)43-31(2)56-29-69-43)57-46(67)36-25-34(63)28-62(36)48(68)44(49(3,4)5)60-39(64)15-10-8-7-9-11-22-54-40(65)26-41(66)58-35-13-12-14-37(42(35)51)70-47-45(52)59-38(27-55-47)61-23-20-50(6,53)21-24-61/h12-14,16-19,27,29-30,34,36,44,63H,7-11,15,20-26,28,53H2,1-6H3,(H2,52,59)(H,54,65)(H,57,67)(H,58,66)(H,60,64)/t30-,34+,36-,44+/m0/s1","RFEUYCHUHZJDIJ-DNEWJPCRSA-N"
"1492","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","81/80","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1032.779","1031.46404864","7.01","71","6","14","7","21","250.89","C51H70ClN11O6S2","InChI=1S/C51H70ClN11O6S2/c1-31(33-17-19-34(20-18-33)44-32(2)57-30-70-44)58-47(68)37-26-35(64)29-63(37)49(69)45(50(3,4)5)61-40(65)16-11-9-7-8-10-12-23-55-41(66)27-42(67)59-36-14-13-15-38(43(36)52)71-48-46(53)60-39(28-56-48)62-24-21-51(6,54)22-25-62/h13-15,17-20,28,30-31,35,37,45,64H,7-12,16,21-27,29,54H2,1-6H3,(H2,53,60)(H,55,66)(H,58,68)(H,59,67)(H,61,65)/t31-,35+,37-,45+/m0/s1","YFSTWJMDUBQIPP-CQHNPHACSA-N"
"1493","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1046.806","1045.4796987","7.55","72","6","14","7","22","250.89","C52H72ClN11O6S2","InChI=1S/C52H72ClN11O6S2/c1-32(34-18-20-35(21-19-34)45-33(2)58-31-71-45)59-48(69)38-27-36(65)30-64(38)50(70)46(51(3,4)5)62-41(66)17-12-10-8-7-9-11-13-24-56-42(67)28-43(68)60-37-15-14-16-39(44(37)53)72-49-47(54)61-40(29-57-49)63-25-22-52(6,55)23-26-63/h14-16,18-21,29,31-32,36,38,46,65H,7-13,17,22-28,30,55H2,1-6H3,(H2,54,61)(H,56,67)(H,59,69)(H,60,68)(H,62,66)/t32-,36+,38-,46+/m0/s1","GPRBATDTNWJZKP-ZIWVEPLMSA-N"
"1494","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1060.833","1059.49534877","8.09","73","6","14","7","23","250.89","C53H74ClN11O6S2","InChI=1S/C53H74ClN11O6S2/c1-33(35-19-21-36(22-20-35)46-34(2)59-32-72-46)60-49(70)39-28-37(66)31-65(39)51(71)47(52(3,4)5)63-42(67)18-13-11-9-7-8-10-12-14-25-57-43(68)29-44(69)61-38-16-15-17-40(45(38)54)73-50-48(55)62-41(30-58-50)64-26-23-53(6,56)24-27-64/h15-17,19-22,30,32-33,37,39,47,66H,7-14,18,23-29,31,56H2,1-6H3,(H2,55,62)(H,57,68)(H,60,70)(H,61,69)(H,63,67)/t33-,37+,39-,47+/m0/s1","BAAPXKIFXITYMU-DPUKGUKXSA-N"
"1495","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNC(=O)CC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/93","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","300","Inhibit growth of KYSE520 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1074.86","1073.51099883","8.63","74","6","14","7","24","250.89","C54H76ClN11O6S2","InChI=1S/C54H76ClN11O6S2/c1-34(36-20-22-37(23-21-36)47-35(2)60-33-73-47)61-50(71)40-29-38(67)32-66(40)52(72)48(53(3,4)5)64-43(68)19-14-12-10-8-7-9-11-13-15-26-58-44(69)30-45(70)62-39-17-16-18-41(46(39)55)74-51-49(56)63-42(31-59-51)65-27-24-54(6,57)25-28-65/h16-18,20-23,31,33-34,38,40,48,67H,7-15,19,24-30,32,57H2,1-6H3,(H2,56,63)(H,58,69)(H,61,71)(H,62,70)(H,64,68)/t34-,38+,40-,48+/m0/s1","CIOBPXATFROPAB-OLMXAHAKSA-N"
"1496","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)CCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1074.86","1073.51099883","7.28","74","6","14","7","24","250.89","C54H76ClN11O6S2","InChI=1S/C54H76ClN11O6S2/c1-34(36-19-21-37(22-20-36)47-35(2)60-33-73-47)61-50(71)40-30-38(67)32-66(40)52(72)48(53(3,4)5)64-44(69)18-13-11-9-7-8-10-12-14-27-58-43(68)23-24-45(70)62-39-16-15-17-41(46(39)55)74-51-49(56)63-42(31-59-51)65-28-25-54(6,57)26-29-65/h15-17,19-22,31,33-34,38,40,48,67H,7-14,18,23-30,32,57H2,1-6H3,(H2,56,63)(H,58,68)(H,61,71)(H,62,70)(H,64,69)/t34-,38+,40-,48+/m0/s1","WMKAYLVXHJOUAH-OLMXAHAKSA-N"
"1497","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNC(=O)CCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1088.887","1087.5266489","7.82","75","6","14","7","25","250.89","C55H78ClN11O6S2","InChI=1S/C55H78ClN11O6S2/c1-35(37-20-22-38(23-21-37)48-36(2)61-34-74-48)62-51(72)41-31-39(68)33-67(41)53(73)49(54(3,4)5)65-45(70)19-14-12-10-8-7-9-11-13-15-28-59-44(69)24-25-46(71)63-40-17-16-18-42(47(40)56)75-52-50(57)64-43(32-60-52)66-29-26-55(6,58)27-30-66/h16-18,20-23,32,34-35,39,41,49,68H,7-15,19,24-31,33,58H2,1-6H3,(H2,57,64)(H,59,69)(H,62,72)(H,63,71)(H,65,70)/t35-,39+,41-,49+/m0/s1","WCYILWGVRFKHNJ-YHWLSQNXSA-N"
"1498","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNC(=O)CCCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1102.914","1101.54229896","8.18","76","6","14","7","26","250.89","C56H80ClN11O6S2","InChI=1S/C56H80ClN11O6S2/c1-36(38-23-25-39(26-24-38)49-37(2)62-35-75-49)63-52(73)42-32-40(69)34-68(42)54(74)50(55(3,4)5)66-47(72)20-14-12-10-8-7-9-11-13-15-29-60-45(70)21-17-22-46(71)64-41-18-16-19-43(48(41)57)76-53-51(58)65-44(33-61-53)67-30-27-56(6,59)28-31-67/h16,18-19,23-26,33,35-36,40,42,50,69H,7-15,17,20-22,27-32,34,59H2,1-6H3,(H2,58,65)(H,60,70)(H,63,73)(H,64,71)(H,66,72)/t36-,40+,42-,50+/m0/s1","HHTDPKNXGUKAHR-WQFCSRJTSA-N"
"1499","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)CCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","80/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1080.776","1079.4487925","3.15","74","6","17","7","24","278.58","C51H70ClN11O9S2","InChI=1S/C51H70ClN11O9S2/c1-31(33-10-12-34(13-11-33)44-32(2)57-30-73-44)58-47(68)37-26-35(64)28-63(37)49(69)45(50(3,4)5)61-42(67)29-72-25-24-71-23-22-70-21-18-55-40(65)14-15-41(66)59-36-8-7-9-38(43(36)52)74-48-46(53)60-39(27-56-48)62-19-16-51(6,54)17-20-62/h7-13,27,30-31,35,37,45,64H,14-26,28-29,54H2,1-6H3,(H2,53,60)(H,55,65)(H,58,68)(H,59,66)(H,61,67)/t31-,35+,37-,45+/m0/s1","NKCAYORTFFXZIT-CQHNPHACSA-N"
"1500","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCNC(=O)CCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","32/87","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1094.803","1093.46444256","3.05","75","6","17","7","25","278.58","C52H72ClN11O9S2","InChI=1S/C52H72ClN11O9S2/c1-32(34-10-12-35(13-11-34)45-33(2)58-31-74-45)59-48(69)38-28-36(65)30-64(38)50(70)46(51(3,4)5)62-43(68)16-22-71-24-26-73-27-25-72-23-19-56-41(66)14-15-42(67)60-37-8-7-9-39(44(37)53)75-49-47(54)61-40(29-57-49)63-20-17-52(6,55)18-21-63/h7-13,29,31-32,36,38,46,65H,14-28,30,55H2,1-6H3,(H2,54,61)(H,56,66)(H,59,69)(H,60,67)(H,62,68)/t32-,36+,38-,46+/m0/s1","WTLCMZCJJKANHP-ZIWVEPLMSA-N"
"1501","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)CCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","53/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1138.856","1137.49065731","2.91","78","6","18","7","28","287.81","C54H76ClN11O10S2","InChI=1S/C54H76ClN11O10S2/c1-34(36-10-12-37(13-11-36)47-35(2)60-33-77-47)61-50(71)40-30-38(67)32-66(40)52(72)48(53(3,4)5)64-45(70)16-22-73-24-26-75-28-29-76-27-25-74-23-19-58-43(68)14-15-44(69)62-39-8-7-9-41(46(39)55)78-51-49(56)63-42(31-59-51)65-20-17-54(6,57)18-21-65/h7-13,31,33-34,38,40,48,67H,14-30,32,57H2,1-6H3,(H2,56,63)(H,58,68)(H,61,71)(H,62,69)(H,64,70)/t34-,38+,40-,48+/m0/s1","LHLMBOONNIHUQA-OLMXAHAKSA-N"
"1502","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCN3CCN(CC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)CC3)C(C)(C)C)C=C2)SC=N1","","","","85/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1101.93","1100.55828337","7.97","76","7","15","6","23","228.27","C56H81ClN12O5S2","InChI=1S/C56H81ClN12O5S2/c1-37(39-19-21-40(22-20-39)49-38(2)61-36-75-49)62-52(73)43-32-41(70)34-69(43)54(74)50(55(3,4)5)65-46(71)18-13-11-9-7-8-10-12-14-25-66-28-30-67(31-29-66)35-47(72)63-42-16-15-17-44(48(42)57)76-53-51(58)64-45(33-60-53)68-26-23-56(6,59)24-27-68/h15-17,19-22,33,36-37,41,43,50,70H,7-14,18,23-32,34-35,59H2,1-6H3,(H2,58,64)(H,62,73)(H,63,72)(H,65,71)/t37-,41+,43-,50+/m0/s1","KIPZFAMCWADNHW-LXTXEPIWSA-N"
"1503","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCN3CCN(CC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)CC3)C(C)(C)C)C=C2)SC=N1","","","","80/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1115.957","1114.57393344","8.52","77","7","15","6","24","228.27","C57H83ClN12O5S2","InChI=1S/C57H83ClN12O5S2/c1-38(40-20-22-41(23-21-40)50-39(2)62-37-76-50)63-53(74)44-33-42(71)35-70(44)55(75)51(56(3,4)5)66-47(72)19-14-12-10-8-7-9-11-13-15-26-67-29-31-68(32-30-67)36-48(73)64-43-17-16-18-45(49(43)58)77-54-52(59)65-46(34-61-54)69-27-24-57(6,60)25-28-69/h16-18,20-23,34,37-38,42,44,51,71H,7-15,19,24-33,35-36,60H2,1-6H3,(H2,59,65)(H,63,74)(H,64,73)(H,66,72)/t38-,42+,44-,51+/m0/s1","BHZJIXQENKLQJI-YDTJZDNNSA-N"
"1504","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC(=O)NC3=CC=CC(SC4=NC=C(N5CCC(C)(N)CC5)N=C4N)=C3Cl)C(C)(C)C)C=C2)SC=N1","","","","62/90","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1059.889","1058.53648531","10.38","73","6","13","6","25","221.79","C55H79ClN10O5S2","InChI=1S/C55H79ClN10O5S2/c1-36(38-24-26-39(27-25-38)48-37(2)60-35-72-48)61-51(70)42-32-40(67)34-66(42)53(71)49(54(3,4)5)64-46(69)23-18-16-14-12-10-8-7-9-11-13-15-17-22-45(68)62-41-20-19-21-43(47(41)56)73-52-50(57)63-44(33-59-52)65-30-28-55(6,58)29-31-65/h19-21,24-27,33,35-36,40,42,49,67H,7-18,22-23,28-32,34,58H2,1-6H3,(H2,57,63)(H,61,70)(H,62,68)(H,64,69)/t36-,40+,42-,49+/m0/s1","GCZODTDGXUMZAE-MRAFNQPSSA-N"
"1505","Q06124","SHP2","VHL","","SHP2-D26","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCN3CCN(C(=O)CCC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)CC3)C(C)(C)C)C=C2)SC=N1","6/2.6","","Degradation of SHP2 in KYSE520/MV4;11 cells after 12 h treatment",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","660/9.9","Inhibit growth of KYSE520/MV4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1115.913","1114.53754793","6.19","77","7","15","6","22","245.34","C56H79ClN12O6S2","InChI=1S/C56H79ClN12O6S2/c1-36(38-17-19-39(20-18-38)49-37(2)61-35-76-49)62-52(74)42-32-40(70)34-69(42)54(75)50(55(3,4)5)65-45(71)16-11-9-7-8-10-12-25-66-28-30-68(31-29-66)47(73)22-21-46(72)63-41-14-13-15-43(48(41)57)77-53-51(58)64-44(33-60-53)67-26-23-56(6,59)24-27-67/h13-15,17-20,33,35-36,40,42,50,70H,7-12,16,21-32,34,59H2,1-6H3,(H2,58,64)(H,62,74)(H,63,72)(H,65,71)/t36-,40+,42-,50+/m0/s1","XJSPAQRZSJUBLB-WQFCSRJTSA-N"
"1506","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCN3CCN(C(=O)CCC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)CC3)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1129.94","1128.55319799","6.73","78","7","15","6","23","245.34","C57H81ClN12O6S2","InChI=1S/C57H81ClN12O6S2/c1-37(39-18-20-40(21-19-39)50-38(2)62-36-77-50)63-53(75)43-33-41(71)35-70(43)55(76)51(56(3,4)5)66-46(72)17-12-10-8-7-9-11-13-26-67-29-31-69(32-30-67)48(74)23-22-47(73)64-42-15-14-16-44(49(42)58)78-54-52(59)65-45(34-61-54)68-27-24-57(6,60)25-28-68/h14-16,18-21,34,36-37,41,43,51,71H,7-13,17,22-33,35,60H2,1-6H3,(H2,59,65)(H,63,75)(H,64,73)(H,66,72)/t37-,41+,43-,51+/m0/s1","BXQHTANMKACEKS-KLBUFCEUSA-N"
"1507","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCOC3=CC=C(NC(=O)CCC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)C=C3)C(C)(C)C)C=C2)SC=N1","","","",">95/>95","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1124.876","1123.49026339","7.18","78","7","15","7","23","260.12","C57H74ClN11O7S2","InChI=1S/C57H74ClN11O7S2/c1-35(37-16-18-38(19-17-37)50-36(2)62-34-77-50)63-53(74)43-31-40(70)33-69(43)55(75)51(56(3,4)5)67-46(71)15-10-8-7-9-11-30-76-41-22-20-39(21-23-41)64-47(72)24-25-48(73)65-42-13-12-14-44(49(42)58)78-54-52(59)66-45(32-61-54)68-28-26-57(6,60)27-29-68/h12-14,16-23,32,34-35,40,43,51,70H,7-11,15,24-31,33,60H2,1-6H3,(H2,59,66)(H,63,74)(H,64,72)(H,65,73)(H,67,71)/t35-,40+,43-,51+/m0/s1","CPTKIRPFOIQTHG-ICUABTHASA-N"
"1508","Q06124","SHP2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCN3CCN(CCCCNC(=O)CCC(=O)NC4=CC=CC(SC5=NC=C(N6CCC(C)(N)CC6)N=C5N)=C4Cl)CC3)C(C)(C)C)C=C2)SC=N1","","","","0/82","% SHP2 degradation in KYSE520 cells after 6 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00471","1130.928","1129.54844696","4.77","78","7","16","7","23","257.37","C56H80ClN13O6S2","InChI=1S/C56H80ClN13O6S2/c1-36(38-15-17-39(18-16-38)49-37(2)62-35-77-49)63-52(75)42-32-40(71)34-70(42)54(76)50(55(3,4)5)66-46(73)14-7-9-24-67-28-30-68(31-29-67)25-10-8-23-60-45(72)19-20-47(74)64-41-12-11-13-43(48(41)57)78-53-51(58)65-44(33-61-53)69-26-21-56(6,59)22-27-69/h11-13,15-18,33,35-36,40,42,50,71H,7-10,14,19-32,34,59H2,1-6H3,(H2,58,65)(H,60,72)(H,63,75)(H,64,74)(H,66,73)/t36-,40+,42-,50+/m0/s1","UCRQERODCAEDKT-WQFCSRJTSA-N"
"1509","Q05397","FAK","CRBN","","FC-11","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","0.31/0.08/0.33","","Degradation of FAK in TM3/PA1/MDA-MB-436 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","949.93","949.290125584","2.19","67","7","18","5","20","273.96","C41H42F3N13O9S","InChI=1S/C41H42F3N13O9S/c1-55(67(2,63)64)35-24(5-4-14-46-35)21-47-34-28(41(42,43)44)22-48-40(52-34)50-26-10-8-25(9-11-26)49-36(59)30-23-56(54-53-30)16-18-66-20-19-65-17-15-45-29-7-3-6-27-33(29)39(62)57(38(27)61)31-12-13-32(58)51-37(31)60/h3-11,14,22-23,31,45H,12-13,15-21H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","RZKZQCHSKWKOAJ-UHFFFAOYSA-N"
"1509","Q05397","FAK","CRBN","","FC-11","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","0.37/0.04","","Degradation of FAK in LNCaP/Ramos cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","949.93","949.290125584","2.19","67","7","18","5","20","273.96","C41H42F3N13O9S","InChI=1S/C41H42F3N13O9S/c1-55(67(2,63)64)35-24(5-4-14-46-35)21-47-34-28(41(42,43)44)22-48-40(52-34)50-26-10-8-25(9-11-26)49-36(59)30-23-56(54-53-30)16-18-66-20-19-65-17-15-45-29-7-3-6-27-33(29)39(62)57(38(27)61)31-12-13-32(58)51-37(31)60/h3-11,14,22-23,31,45H,12-13,15-21H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","RZKZQCHSKWKOAJ-UHFFFAOYSA-N"
"1509","Q05397","FAK","CRBN","","FC-11","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","1.3/0.4","","Degradation of Fak in primary Sertoli/germ cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1007/s13238-020-00732-8","949.93","949.290125584","2.19","67","7","18","5","20","273.96","C41H42F3N13O9S","InChI=1S/C41H42F3N13O9S/c1-55(67(2,63)64)35-24(5-4-14-46-35)21-47-34-28(41(42,43)44)22-48-40(52-34)50-26-10-8-25(9-11-26)49-36(59)30-23-56(54-53-30)16-18-66-20-19-65-17-15-45-29-7-3-6-27-33(29)39(62)57(38(27)61)31-12-13-32(58)51-37(31)60/h3-11,14,22-23,31,45H,12-13,15-21H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","RZKZQCHSKWKOAJ-UHFFFAOYSA-N"
"1510","","BCR-ABL","CRBN","","Azo-PROTAC-2C","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCOC3=CC=C(/N=N/C4=CC=C(C(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)C=C4)C=C3)CC2)=N1","391","","Degradation of BCR-ABL in K562 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02058","953.486","952.29942584","6.81","68","9","15","4","14","215.81","C48H45ClN12O6S","InChI=1S/C48H45ClN12O6S/c1-28-5-3-7-36(49)43(28)56-46(65)39-26-50-48(68-39)54-40-25-41(52-29(2)51-40)60-21-19-59(20-22-60)23-24-67-33-15-13-32(14-16-33)58-57-31-11-9-30(10-12-31)44(63)53-37-8-4-6-34-35(37)27-61(47(34)66)38-17-18-42(62)55-45(38)64/h3-16,25-26,38H,17-24,27H2,1-2H3,(H,53,63)(H,56,65)(H,55,62,64)(H,50,51,52,54)/b58-57+","QYPFNLRIBGXFNO-UPRQXYPZSA-N"
"1511","","BCR-ABL","CRBN","","Azo-PROTAC-3C","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCOC3=CC=C(/N=N/C4=CC=C(C(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)C=C4)C=C3)CC2)=N1","114","","Degradation of BCR-ABL in K562 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02058","967.513","966.315075904","7.16","69","9","15","4","15","215.81","C49H47ClN12O6S","InChI=1S/C49H47ClN12O6S/c1-29-6-3-8-37(50)44(29)57-47(66)40-27-51-49(69-40)55-41-26-42(53-30(2)52-41)61-23-21-60(22-24-61)20-5-25-68-34-16-14-33(15-17-34)59-58-32-12-10-31(11-13-32)45(64)54-38-9-4-7-35-36(38)28-62(48(35)67)39-18-19-43(63)56-46(39)65/h3-4,6-17,26-27,39H,5,18-25,28H2,1-2H3,(H,54,64)(H,57,66)(H,56,63,65)(H,51,52,53,55)/b59-58+","QTQHNLIFWIPLAX-NTDNRIHLSA-N"
"1512","","BCR-ABL","CRBN","","Azo-PROTAC-4C","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCOC3=CC=C(/N=N/C4=CC=C(C(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)C=C4)C=C3)CC2)=N1","62","","Degradation of BCR-ABL in K562 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","68","Inhibit proliferation of K562 cells","28","Inhibit viability of K562 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02058","981.54","980.330725968","7.52","70","9","15","4","16","215.81","C50H49ClN12O6S","InChI=1S/C50H49ClN12O6S/c1-30-7-5-9-38(51)45(30)58-48(67)41-28-52-50(70-41)56-42-27-43(54-31(2)53-42)62-24-22-61(23-25-62)21-3-4-26-69-35-17-15-34(16-18-35)60-59-33-13-11-32(12-14-33)46(65)55-39-10-6-8-36-37(39)29-63(49(36)68)40-19-20-44(64)57-47(40)66/h5-18,27-28,40H,3-4,19-26,29H2,1-2H3,(H,55,65)(H,58,67)(H,57,64,66)(H,52,53,54,56)/b60-59+","DYBUXZNKVNIICM-BCLHHTJESA-N"
"1513","","BCR-ABL","CRBN","","Azo-PROTAC-5C","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCOC3=CC=C(/N=N/C4=CC=C(C(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)C=C4)C=C3)CC2)=N1",">500","","Degradation of BCR-ABL in K562 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02058","995.567","994.346376032","7.88","71","9","15","4","17","215.81","C51H51ClN12O6S","InChI=1S/C51H51ClN12O6S/c1-31-8-6-10-39(52)46(31)59-49(68)42-29-53-51(71-42)57-43-28-44(55-32(2)54-43)63-25-23-62(24-26-63)22-4-3-5-27-70-36-18-16-35(17-19-36)61-60-34-14-12-33(13-15-34)47(66)56-40-11-7-9-37-38(40)30-64(50(37)69)41-20-21-45(65)58-48(41)67/h6-19,28-29,41H,3-5,20-27,30H2,1-2H3,(H,56,66)(H,59,68)(H,58,65,67)(H,53,54,55,57)/b61-60+","OGTSSFRBYDKZEX-OGAWRBAASA-N"
"1514","","BCR-ABL","CRBN","","Azo-PROTAC-6C","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCCOC3=CC=C(/N=N/C4=CC=C(C(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)C=C4)C=C3)CC2)=N1",">500","","Degradation of BCR-ABL in K562 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.9b02058","1009.594","1008.3620261","8.24","72","9","15","4","18","215.81","C52H53ClN12O6S","InChI=1S/C52H53ClN12O6S/c1-32-9-7-11-40(53)47(32)60-50(69)43-30-54-52(72-43)58-44-29-45(56-33(2)55-44)64-26-24-63(25-27-64)23-5-3-4-6-28-71-37-19-17-36(18-20-37)62-61-35-15-13-34(14-16-35)48(67)57-41-12-8-10-38-39(41)31-65(51(38)70)42-21-22-46(66)59-49(42)68/h7-20,29-30,42H,3-6,21-28,31H2,1-2H3,(H,57,67)(H,60,69)(H,59,66,68)(H,54,55,56,58)/b62-61+","FRVLEPNINKRXPD-AIDPXTNXSA-N"
"1515","P25440","BRD2","VHL","","photoPROTAC-1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3=CC(F)=C(/N=N/C4=C(F)C=C(C(=O)NC[C@@H]5N=C(C6=CC=C(Cl)C=C6)C6=C(SC(C)=C6C)N6C(C)=NN=C56)C=C4F)C(F)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.9b00713","1108.645","1107.30624626","9.24","77","9","14","4","13","208.52","C54H50ClF4N11O5S2","InChI=1S/C54H50ClF4N11O5S2/c1-25-27(3)77-53-42(25)43(30-12-14-34(55)15-13-30)63-40(48-68-65-28(4)70(48)53)22-61-49(72)32-16-36(56)44(37(57)17-32)66-67-45-38(58)18-33(19-39(45)59)50(73)64-47(54(5,6)7)52(75)69-23-35(71)20-41(69)51(74)60-21-29-8-10-31(11-9-29)46-26(2)62-24-76-46/h8-19,24,35,40-41,47,71H,20-23H2,1-7H3,(H,60,74)(H,61,72)(H,64,73)/b67-66+/t35-,40+,41+,47-/m1/s1","MKRXFVVTMRJGBY-QYYMYARESA-N"
"1516","P25440","BRD2","CRBN","","PHOTAC-I-1","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","907.41","906.267457016","4.28","64","8","15","3","14","220.16","C44H43ClN10O8S","InChI=1S/C44H43ClN10O8S/c1-22-23(2)64-44-38(22)39(25-9-11-26(45)12-10-25)48-31(41-53-50-24(3)55(41)44)19-36(57)46-15-16-47-37(58)21-63-40-33(61-4)17-27(18-34(40)62-5)51-52-30-8-6-7-28-29(30)20-54(43(28)60)32-13-14-35(56)49-42(32)59/h6-12,17-18,31-32H,13-16,19-21H2,1-5H3,(H,46,57)(H,47,58)(H,49,56,59)/b52-51+/t31-,32?/m0/s1","LQCVQUVQOKDZMA-XVPPCTQSSA-N"
"1516","Q15059","BRD3","CRBN","","PHOTAC-I-1","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","907.41","906.267457016","4.28","64","8","15","3","14","220.16","C44H43ClN10O8S","InChI=1S/C44H43ClN10O8S/c1-22-23(2)64-44-38(22)39(25-9-11-26(45)12-10-25)48-31(41-53-50-24(3)55(41)44)19-36(57)46-15-16-47-37(58)21-63-40-33(61-4)17-27(18-34(40)62-5)51-52-30-8-6-7-28-29(30)20-54(43(28)60)32-13-14-35(56)49-42(32)59/h6-12,17-18,31-32H,13-16,19-21H2,1-5H3,(H,46,57)(H,47,58)(H,49,56,59)/b52-51+/t31-,32?/m0/s1","LQCVQUVQOKDZMA-XVPPCTQSSA-N"
"1516","O60885","BRD4","CRBN","","PHOTAC-I-1","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","907.41","906.267457016","4.28","64","8","15","3","14","220.16","C44H43ClN10O8S","InChI=1S/C44H43ClN10O8S/c1-22-23(2)64-44-38(22)39(25-9-11-26(45)12-10-25)48-31(41-53-50-24(3)55(41)44)19-36(57)46-15-16-47-37(58)21-63-40-33(61-4)17-27(18-34(40)62-5)51-52-30-8-6-7-28-29(30)20-54(43(28)60)32-13-14-35(56)49-42(32)59/h6-12,17-18,31-32H,13-16,19-21H2,1-5H3,(H,46,57)(H,47,58)(H,49,56,59)/b52-51+/t31-,32?/m0/s1","LQCVQUVQOKDZMA-XVPPCTQSSA-N"
"1517","P25440","BRD2","CRBN","","PHOTAC-I-2","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","921.437","920.28310708","4.64","65","8","15","3","15","220.16","C45H45ClN10O8S","InChI=1S/C45H45ClN10O8S/c1-23-24(2)65-45-39(23)40(26-10-12-27(46)13-11-26)49-32(42-54-51-25(3)56(42)45)20-37(58)47-16-7-17-48-38(59)22-64-41-34(62-4)18-28(19-35(41)63-5)52-53-31-9-6-8-29-30(31)21-55(44(29)61)33-14-15-36(57)50-43(33)60/h6,8-13,18-19,32-33H,7,14-17,20-22H2,1-5H3,(H,47,58)(H,48,59)(H,50,57,60)/b53-52+/t32-,33?/m0/s1","TWLVSZYPENTZJC-HNKSWKDBSA-N"
"1517","Q15059","BRD3","CRBN","","PHOTAC-I-2","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","921.437","920.28310708","4.64","65","8","15","3","15","220.16","C45H45ClN10O8S","InChI=1S/C45H45ClN10O8S/c1-23-24(2)65-45-39(23)40(26-10-12-27(46)13-11-26)49-32(42-54-51-25(3)56(42)45)20-37(58)47-16-7-17-48-38(59)22-64-41-34(62-4)18-28(19-35(41)63-5)52-53-31-9-6-8-29-30(31)21-55(44(29)61)33-14-15-36(57)50-43(33)60/h6,8-13,18-19,32-33H,7,14-17,20-22H2,1-5H3,(H,47,58)(H,48,59)(H,50,57,60)/b53-52+/t32-,33?/m0/s1","TWLVSZYPENTZJC-HNKSWKDBSA-N"
"1517","O60885","BRD4","CRBN","","PHOTAC-I-2","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","921.437","920.28310708","4.64","65","8","15","3","15","220.16","C45H45ClN10O8S","InChI=1S/C45H45ClN10O8S/c1-23-24(2)65-45-39(23)40(26-10-12-27(46)13-11-26)49-32(42-54-51-25(3)56(42)45)20-37(58)47-16-7-17-48-38(59)22-64-41-34(62-4)18-28(19-35(41)63-5)52-53-31-9-6-8-29-30(31)21-55(44(29)61)33-14-15-36(57)50-43(33)60/h6,8-13,18-19,32-33H,7,14-17,20-22H2,1-5H3,(H,47,58)(H,48,59)(H,50,57,60)/b53-52+/t32-,33?/m0/s1","TWLVSZYPENTZJC-HNKSWKDBSA-N"
"1518","P25440","BRD2","CRBN","","PHOTAC-I-3","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","88.5","Inhibit viability of RS4;11 cells under pulsed 390nm irradiation","","","","","","","","","","","","","10.1126/sciadv.aay5064","935.464","934.298757144","5.0","66","8","15","3","16","220.16","C46H47ClN10O8S","InChI=1S/C46H47ClN10O8S/c1-24-25(2)66-46-40(24)41(27-11-13-28(47)14-12-27)50-33(43-55-52-26(3)57(43)46)21-38(59)48-17-6-7-18-49-39(60)23-65-42-35(63-4)19-29(20-36(42)64-5)53-54-32-10-8-9-30-31(32)22-56(45(30)62)34-15-16-37(58)51-44(34)61/h8-14,19-20,33-34H,6-7,15-18,21-23H2,1-5H3,(H,48,59)(H,49,60)(H,51,58,61)/b54-53+/t33-,34?/m0/s1","SGZZPSOQAWRZGE-RCBZUBGNSA-N"
"1518","Q15059","BRD3","CRBN","","PHOTAC-I-3","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","88.5","Inhibit viability of RS4;11 cells under pulsed 390nm irradiation","","","","","","","","","","","","","10.1126/sciadv.aay5064","935.464","934.298757144","5.0","66","8","15","3","16","220.16","C46H47ClN10O8S","InChI=1S/C46H47ClN10O8S/c1-24-25(2)66-46-40(24)41(27-11-13-28(47)14-12-27)50-33(43-55-52-26(3)57(43)46)21-38(59)48-17-6-7-18-49-39(60)23-65-42-35(63-4)19-29(20-36(42)64-5)53-54-32-10-8-9-30-31(32)22-56(45(30)62)34-15-16-37(58)51-44(34)61/h8-14,19-20,33-34H,6-7,15-18,21-23H2,1-5H3,(H,48,59)(H,49,60)(H,51,58,61)/b54-53+/t33-,34?/m0/s1","SGZZPSOQAWRZGE-RCBZUBGNSA-N"
"1518","O60885","BRD4","CRBN","","PHOTAC-I-3","COC1=CC(/N=N/C2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=CC(OC)=C1OCC(=O)NCCCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","88.5","Inhibit viability of RS4;11 cells under pulsed 390nm irradiation","","","","","","","","","","","","","10.1126/sciadv.aay5064","935.464","934.298757144","5.0","66","8","15","3","16","220.16","C46H47ClN10O8S","InChI=1S/C46H47ClN10O8S/c1-24-25(2)66-46-40(24)41(27-11-13-28(47)14-12-27)50-33(43-55-52-26(3)57(43)46)21-38(59)48-17-6-7-18-49-39(60)23-65-42-35(63-4)19-29(20-36(42)64-5)53-54-32-10-8-9-30-31(32)22-56(45(30)62)34-15-16-37(58)51-44(34)61/h8-14,19-20,33-34H,6-7,15-18,21-23H2,1-5H3,(H,48,59)(H,49,60)(H,51,58,61)/b54-53+/t33-,34?/m0/s1","SGZZPSOQAWRZGE-RCBZUBGNSA-N"
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"1528","O60885","BRD4","CRBN","","PHOTAC-I-13","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@@H](CC(=O)NC1=CC=C3/N=N\C4=CC=C(NC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4CCC3=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","935.423","934.241242268","6.0","67","10","14","3","9","218.77","C48H39ClN10O7S","InChI=1S/C48H39ClN10O7S/c1-23-24(2)67-48-41(23)43(26-9-11-29(49)12-10-26)52-35(44-57-54-25(3)58(44)48)21-39(61)50-30-13-15-33-27(19-30)7-8-28-20-31(14-16-34(28)56-55-33)51-40(62)22-66-37-6-4-5-32-42(37)47(65)59(46(32)64)36-17-18-38(60)53-45(36)63/h4-6,9-16,19-20,35-36H,7-8,17-18,21-22H2,1-3H3,(H,50,61)(H,51,62)(H,53,60,63)/b56-55-/t35-,36?/m1/s1","LZTPVXATJDYENS-LTDQXGDMSA-N"
"1529","P62942","FKBP12","CRBN","","PHOTAC-II-1","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCNC(=O)COC2=C(OC)C=C(/N=N/C3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","1104.224","1103.48516451","6.61","80","7","17","3","26","268.46","C58H69N7O15","InChI=1S/C58H69N7O15/c1-8-58(2,3)53(69)56(72)64-27-10-9-18-43(64)57(73)80-44(22-19-35-20-23-45(74-4)46(28-35)75-5)36-14-11-15-38(29-36)78-33-50(67)59-25-13-26-60-51(68)34-79-52-47(76-6)30-37(31-48(52)77-7)62-63-41-17-12-16-39-40(41)32-65(55(39)71)42-21-24-49(66)61-54(42)70/h11-12,14-17,20,23,28-31,42-44H,8-10,13,18-19,21-22,24-27,32-34H2,1-7H3,(H,59,67)(H,60,68)(H,61,66,70)/b63-62+/t42?,43-,44+/m0/s1","GEZKTBXHVGULHM-LKHQGNJTSA-N"
"1530","P62942","FKBP12","CRBN","","PHOTAC-II-2","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCCNC(=O)COC2=C(OC)C=C(/N=N/C3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","1118.251","1117.50081457","6.97","81","7","17","3","27","268.46","C59H71N7O15","InChI=1S/C59H71N7O15/c1-8-59(2,3)54(70)57(73)65-28-12-9-19-44(65)58(74)81-45(23-20-36-21-24-46(75-4)47(29-36)76-5)37-15-13-16-39(30-37)79-34-51(68)60-26-10-11-27-61-52(69)35-80-53-48(77-6)31-38(32-49(53)78-7)63-64-42-18-14-17-40-41(42)33-66(56(40)72)43-22-25-50(67)62-55(43)71/h13-18,21,24,29-32,43-45H,8-12,19-20,22-23,25-28,33-35H2,1-7H3,(H,60,68)(H,61,69)(H,62,67,71)/b64-63+/t43?,44-,45+/m0/s1","ZIINLNWQOBVXNW-MMWJDCCRSA-N"
"1531","P62942","FKBP12","CRBN","","PHOTAC-II-3","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCCCNC(=O)COC2=C(OC)C=C(/N=N/C3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","1132.278","1131.51646464","7.33","82","7","17","3","28","268.46","C60H73N7O15","InChI=1S/C60H73N7O15/c1-8-60(2,3)55(71)58(74)66-29-13-10-20-45(66)59(75)82-46(24-21-37-22-25-47(76-4)48(30-37)77-5)38-16-14-17-40(31-38)80-35-52(69)61-27-11-9-12-28-62-53(70)36-81-54-49(78-6)32-39(33-50(54)79-7)64-65-43-19-15-18-41-42(43)34-67(57(41)73)44-23-26-51(68)63-56(44)72/h14-19,22,25,30-33,44-46H,8-13,20-21,23-24,26-29,34-36H2,1-7H3,(H,61,69)(H,62,70)(H,63,68,72)/b65-64+/t44?,45-,46+/m0/s1","OXBMGUVLUAAETN-KKOYCJNQSA-N"
"1532","P62942","FKBP12","CRBN","","PHOTAC-II-4","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCCCCNC(=O)COC2=C(OC)C=C(/N=N/C3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","1146.305","1145.5321147","7.68","83","7","17","3","29","268.46","C61H75N7O15","InChI=1S/C61H75N7O15/c1-8-61(2,3)56(72)59(75)67-30-14-11-21-46(67)60(76)83-47(25-22-38-23-26-48(77-4)49(31-38)78-5)39-17-15-18-41(32-39)81-36-53(70)62-28-12-9-10-13-29-63-54(71)37-82-55-50(79-6)33-40(34-51(55)80-7)65-66-44-20-16-19-42-43(44)35-68(58(42)74)45-24-27-52(69)64-57(45)73/h15-20,23,26,31-34,45-47H,8-14,21-22,24-25,27-30,35-37H2,1-7H3,(H,62,70)(H,63,71)(H,64,69,73)/b66-65+/t45?,46-,47+/m0/s1","ZFGGYSBFWRYKTG-HPELKYJRSA-N"
"1533","P62942","FKBP12","CRBN","","PHOTAC-II-5","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCNC(=O)COC2=CC=C(/N=N/C3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/sciadv.aay5064","1030.145","1029.44838508","6.31","75","7","15","3","23","250.0","C55H63N7O13","InChI=1S/C55H63N7O13/c1-6-55(2,3)50(66)53(69)61-28-8-7-15-43(61)54(70)75-44(23-16-34-17-24-45(71-4)46(29-34)72-5)35-11-9-12-38(30-35)74-33-49(65)57-27-26-56-48(64)32-73-37-20-18-36(19-21-37)59-60-41-14-10-13-39-40(41)31-62(52(39)68)42-22-25-47(63)58-51(42)67/h9-14,17-21,24,29-30,42-44H,6-8,15-16,22-23,25-28,31-33H2,1-5H3,(H,56,64)(H,57,65)(H,58,63,67)/b60-59+/t42?,43-,44+/m0/s1","DEFVIDIMHDJUKH-MNXULEANSA-N"
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"1535","O60885","BRD4","VHL","6SIS","macroPROTAC-1","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOCCOC3=C2)SC=N1","25-125","","Degradation of BRD4 in HeLa cells after 4/18 h treatment","","","","","","","180","Kd of BRD4 BD2 was tested by ITC","","","-9.2","-6.25","-2.7","ITC in BRD4 BD2","","","","","","","","","47","ITC","33","FP","-10","-6.7","-3.3","ITC","","","","","","","","","2","Kd between VHL and the complex of protac and BRD4 BD2 was tested by ITC","","","-11.9","-10.9","-1","ITC between VHL and PROTAC:BRD4 BD2","","","","","","","640/300","Inhibit proliferation of 22RV1/MV4;11 cells","","","","","","","","","","","","","10.1002/anie.201914396","1118.777","1117.41682368","4.48","77","8","18","4","5","239.18","C54H68ClN9O11S2","InChI=1S/C54H68ClN9O11S2/c1-31-33(3)77-53-46(31)47(35-10-12-38(55)13-11-35)59-41(50-62-61-34(4)64(50)53)24-44(66)58-39-27-72-17-14-70-16-19-74-29-45(67)60-49(54(5,6)7)52(69)63-26-40(65)23-42(63)51(68)56-25-37-9-8-36(48-32(2)57-30-76-48)22-43(37)75-21-20-71-15-18-73-28-39/h8-13,22,30,39-42,49,65H,14-21,23-29H2,1-7H3,(H,56,68)(H,58,66)(H,60,67)/t39-,40+,41-,42-,49+/m0/s1","GMEHQGWGMMKWAX-NIQMDXQVSA-N"
"1535","P25440","BRD2","VHL","","macroPROTAC-1","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOCCOC3=C2)SC=N1",">125","","Degradation of BRD2 in HeLa cells after 4/18 h treatment","","","","","","","743","Kd of BRD2 BD1 was tested by ITC","","","-8.4","-9.6","1.2","ITC in BRD2 BD1","","","","","","","","","47","ITC","33","FP","-10","-6.7","-3.3","ITC","","","","","","","","","70","Kd between VHL and the complex of protac and BRD2 BD1 was tested by ITC","","","-9.9","-4.8","-5","ITC between VHL and PROTAC:BRD2 BD1","","","","","","","640/300","Inhibit proliferation of 22RV1/MV4;11 cells","","","","","","","","","","","","","10.1002/anie.201914396","1118.777","1117.41682368","4.48","77","8","18","4","5","239.18","C54H68ClN9O11S2","InChI=1S/C54H68ClN9O11S2/c1-31-33(3)77-53-46(31)47(35-10-12-38(55)13-11-35)59-41(50-62-61-34(4)64(50)53)24-44(66)58-39-27-72-17-14-70-16-19-74-29-45(67)60-49(54(5,6)7)52(69)63-26-40(65)23-42(63)51(68)56-25-37-9-8-36(48-32(2)57-30-76-48)22-43(37)75-21-20-71-15-18-73-28-39/h8-13,22,30,39-42,49,65H,14-21,23-29H2,1-7H3,(H,56,68)(H,58,66)(H,60,67)/t39-,40+,41-,42-,49+/m0/s1","GMEHQGWGMMKWAX-NIQMDXQVSA-N"
"1535","Q15059","BRD3","VHL","","macroPROTAC-1","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOCCOC3=C2)SC=N1",">125","","Degradation of BRD3 in HeLa cells after 4/18 h treatment","","","","","","","","","","","","","","","","","","","","","","","47","ITC","33","FP","-10","-6.7","-3.3","ITC","","","","","","","","","","","","","","","","","","","","","","","640/300","Inhibit proliferation of 22RV1/MV4;11 cells","","","","","","","","","","","","","10.1002/anie.201914396","1118.777","1117.41682368","4.48","77","8","18","4","5","239.18","C54H68ClN9O11S2","InChI=1S/C54H68ClN9O11S2/c1-31-33(3)77-53-46(31)47(35-10-12-38(55)13-11-35)59-41(50-62-61-34(4)64(50)53)24-44(66)58-39-27-72-17-14-70-16-19-74-29-45(67)60-49(54(5,6)7)52(69)63-26-40(65)23-42(63)51(68)56-25-37-9-8-36(48-32(2)57-30-76-48)22-43(37)75-21-20-71-15-18-73-28-39/h8-13,22,30,39-42,49,65H,14-21,23-29H2,1-7H3,(H,56,68)(H,58,66)(H,60,67)/t39-,40+,41-,42-,49+/m0/s1","GMEHQGWGMMKWAX-NIQMDXQVSA-N"
"1536","P25440","BRD2","VHL","","macroPROTAC-2","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOC3=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201914396","1074.724","1073.39060893","4.63","74","8","17","4","5","229.95","C52H64ClN9O10S2","InChI=1S/C52H64ClN9O10S2/c1-29-31(3)74-51-44(29)45(33-10-12-36(53)13-11-33)57-39(48-60-59-32(4)62(48)51)22-42(64)56-37-25-69-16-14-68-15-17-71-27-43(65)58-47(52(5,6)7)50(67)61-24-38(63)21-40(61)49(66)54-23-35-9-8-34(46-30(2)55-28-73-46)20-41(35)72-19-18-70-26-37/h8-13,20,28,37-40,47,63H,14-19,21-27H2,1-7H3,(H,54,66)(H,56,64)(H,58,65)/t37-,38+,39-,40-,47+/m0/s1","FDMPFPBAHZXCOY-NNZXRONMSA-N"
"1536","Q15059","BRD3","VHL","","macroPROTAC-2","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOC3=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201914396","1074.724","1073.39060893","4.63","74","8","17","4","5","229.95","C52H64ClN9O10S2","InChI=1S/C52H64ClN9O10S2/c1-29-31(3)74-51-44(29)45(33-10-12-36(53)13-11-33)57-39(48-60-59-32(4)62(48)51)22-42(64)56-37-25-69-16-14-68-15-17-71-27-43(65)58-47(52(5,6)7)50(67)61-24-38(63)21-40(61)49(66)54-23-35-9-8-34(46-30(2)55-28-73-46)20-41(35)72-19-18-70-26-37/h8-13,20,28,37-40,47,63H,14-19,21-27H2,1-7H3,(H,54,66)(H,56,64)(H,58,65)/t37-,38+,39-,40-,47+/m0/s1","FDMPFPBAHZXCOY-NNZXRONMSA-N"
"1536","O60885","BRD4","VHL","","macroPROTAC-2","CC1=C(C2=CC=C3CNC(=O)[C@@H]4C[C@@H](O)CN4C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOC[C@H](NC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)COCCOC3=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.201914396","1074.724","1073.39060893","4.63","74","8","17","4","5","229.95","C52H64ClN9O10S2","InChI=1S/C52H64ClN9O10S2/c1-29-31(3)74-51-44(29)45(33-10-12-36(53)13-11-33)57-39(48-60-59-32(4)62(48)51)22-42(64)56-37-25-69-16-14-68-15-17-71-27-43(65)58-47(52(5,6)7)50(67)61-24-38(63)21-40(61)49(66)54-23-35-9-8-34(46-30(2)55-28-73-46)20-41(35)72-19-18-70-26-37/h8-13,20,28,37-40,47,63H,14-19,21-27H2,1-7H3,(H,54,66)(H,56,64)(H,58,65)/t37-,38+,39-,40-,47+/m0/s1","FDMPFPBAHZXCOY-NNZXRONMSA-N"
"1537","Q06187","BTK","CRBN","","MT-797","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","787.834","787.307809272","2.89","58","8","14","3","14","213.2","C41H41N9O8","InChI=1S/C41H41N9O8/c42-37-35-36(25-9-11-28(12-10-25)58-27-5-2-1-3-6-27)47-50(38(35)44-24-43-37)26-15-17-48(18-16-26)19-20-56-21-22-57-23-33(52)45-30-8-4-7-29-34(30)41(55)49(40(29)54)31-13-14-32(51)46-39(31)53/h1-12,24,26,31H,13-23H2,(H,45,52)(H2,42,43,44)(H,46,51,53)","VIHNRRRMTAYCFU-UHFFFAOYSA-N"
"1538","P00533","EGFR L858R/T790M","CRBN","","JBJ-07-038","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC(F)=CC=C8O)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","19","IC50 of L858R/T790M EGFR was assessed using HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","477","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","10.1002/anie.202003500","975.069","974.343289052","4.21","70","9","15","4","20","212.28","C50H51FN8O10S","InChI=1S/C50H51FN8O10S/c51-34-8-12-41(60)38(29-34)44(46(63)55-50-53-15-27-70-50)58-30-33-5-4-32(28-37(33)47(58)64)31-6-9-35(10-7-31)57-18-16-56(17-19-57)20-22-68-24-26-69-25-23-67-21-14-52-39-3-1-2-36-43(39)49(66)59(48(36)65)40-11-13-42(61)54-45(40)62/h1-10,12,15,27-29,40,44,52,60H,11,13-14,16-26,30H2,(H,53,55,63)(H,54,61,62)","YJHQLBPJGVDMDW-UHFFFAOYSA-N"
"1539","Q06187","BTK","CRBN","","MT-783","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2C1CCN(CCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.8b00391","743.781","743.281594524","3.03","55","8","13","3","11","203.97","C39H37N9O7","InChI=1S/C39H37N9O7/c40-35-33-34(23-9-11-26(12-10-23)55-25-5-2-1-3-6-25)45-48(36(33)42-22-41-35)24-15-17-46(18-16-24)19-20-54-21-31(50)43-28-8-4-7-27-32(28)39(53)47(38(27)52)29-13-14-30(49)44-37(29)51/h1-12,22,24,29H,13-21H2,(H,43,50)(H2,40,41,42)(H,44,49,51)","MCJQJGRMVWSQFS-UHFFFAOYSA-N"
"1540","P00533","EGFR L858R/T790M","CRBN","","JBJ-07-200","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC(F)=CC=C8F)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","390","IC50 of L858R/T790M EGFR was assessed using HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","153","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","10.1002/anie.202003500","977.06","976.33895262","4.67","70","9","14","3","20","192.05","C50H50F2N8O9S","InChI=1S/C50H50F2N8O9S/c51-34-8-11-39(52)38(29-34)44(46(63)56-50-54-15-27-70-50)59-30-33-5-4-32(28-37(33)47(59)64)31-6-9-35(10-7-31)58-18-16-57(17-19-58)20-22-68-24-26-69-25-23-67-21-14-53-40-3-1-2-36-43(40)49(66)60(48(36)65)41-12-13-42(61)55-45(41)62/h1-11,15,27-29,41,44,53H,12-14,16-26,30H2,(H,54,56,63)(H,55,61,62)","WHLIZTUDKDTXIF-UHFFFAOYSA-N"
"1541","P00533","EGFR L858R/T790M","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCOCCNC(=O)CN1CCN(C2=CC=C(C3=CC=C4CN(C(C(=O)NC5=NC=CS5)C5=CC=CC=C5)C(=O)C4=C3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","1056.168","1055.38473926","2.6","76","9","16","4","24","247.45","C54H57N9O12S","InChI=1S/C54H57N9O12S/c64-44-16-15-42(49(67)58-44)63-52(70)40-7-4-8-43(47(40)53(63)71)75-34-46(66)56-18-25-73-27-29-74-28-26-72-24-17-55-45(65)33-60-20-22-61(23-21-60)39-13-11-35(12-14-39)37-9-10-38-32-62(51(69)41(38)31-37)48(36-5-2-1-3-6-36)50(68)59-54-57-19-30-76-54/h1-14,19,30-31,42,48H,15-18,20-29,32-34H2,(H,55,65)(H,56,66)(H,57,59,68)(H,58,64,67)","SGYWRAOXWISULN-UHFFFAOYSA-N"
"1542","P00533","EGFR L858R/T790M","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCNC(=O)CN1CCN(C2=CC=C(C3=CC=C4CN(C(C(=O)NC5=NC=CS5)C5=CC=CC=C5)C(=O)C4=C3)C=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","952.063","951.337395148","3.75","69","9","13","4","17","219.76","C50H49N9O9S","InChI=1S/C50H49N9O9S/c60-40-18-17-38(45(63)54-40)59-48(66)36-9-6-10-39(43(36)49(59)67)68-30-42(62)52-20-5-4-19-51-41(61)29-56-22-24-57(25-23-56)35-15-13-31(14-16-35)33-11-12-34-28-58(47(65)37(34)27-33)44(32-7-2-1-3-8-32)46(64)55-50-53-21-26-69-50/h1-3,6-16,21,26-27,38,44H,4-5,17-20,22-25,28-30H2,(H,51,61)(H,52,62)(H,53,55,64)(H,54,60,63)","DRFUYHRFDSPHBM-UHFFFAOYSA-N"
"1543","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","865.029","864.341752256","6.34","63","9","11","3","15","164.36","C48H48N8O6S","InChI=1S/C48H48N8O6S/c57-40-20-19-39(43(58)51-40)56-46(61)36-11-8-12-38(41(36)47(56)62)49-21-6-1-2-7-23-53-24-26-54(27-25-53)35-17-15-31(16-18-35)33-13-14-34-30-55(45(60)37(34)29-33)42(32-9-4-3-5-10-32)44(59)52-48-50-22-28-63-48/h3-5,8-18,22,28-29,39,42,49H,1-2,6-7,19-21,23-27,30H2,(H,50,52,59)(H,51,57,58)","PILAFINNPPGQBT-UHFFFAOYSA-N"
"1544","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","893.083","892.373052384","7.42","65","9","11","3","17","164.36","C50H52N8O6S","InChI=1S/C50H52N8O6S/c59-42-22-21-41(45(60)53-42)58-48(63)38-13-10-14-40(43(38)49(58)64)51-23-8-3-1-2-4-9-25-55-26-28-56(29-27-55)37-19-17-33(18-20-37)35-15-16-36-32-57(47(62)39(36)31-35)44(34-11-6-5-7-12-34)46(61)54-50-52-24-30-65-50/h5-7,10-20,24,30-31,41,44,51H,1-4,8-9,21-23,25-29,32H2,(H,52,54,61)(H,53,59,60)","OARWNJPFFUUHMW-UHFFFAOYSA-N"
"1545","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","880.984","880.300281368","4.16","64","9","12","3","14","190.66","C47H44N8O8S","InChI=1S/C47H44N8O8S/c56-38-16-15-37(42(58)50-38)55-45(61)34-7-4-8-36(40(34)46(55)62)48-18-25-63-24-17-39(57)53-22-20-52(21-23-53)33-13-11-29(12-14-33)31-9-10-32-28-54(44(60)35(32)27-31)41(30-5-2-1-3-6-30)43(59)51-47-49-19-26-64-47/h1-14,19,26-27,37,41,48H,15-18,20-25,28H2,(H,49,51,59)(H,50,56,58)","MPSFLLYYUBBAEB-UHFFFAOYSA-N"
"1546","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","925.037","924.326496116","4.01","67","9","13","3","17","199.89","C49H48N8O9S","InChI=1S/C49H48N8O9S/c58-40-16-15-39(44(60)52-40)57-47(63)36-7-4-8-38(42(36)48(57)64)50-18-25-66-27-26-65-24-17-41(59)55-22-20-54(21-23-55)35-13-11-31(12-14-35)33-9-10-34-30-56(46(62)37(34)29-33)43(32-5-2-1-3-6-32)45(61)53-49-51-19-28-67-49/h1-14,19,28-29,39,43,50H,15-18,20-27,30H2,(H,51,53,61)(H,52,58,60)","BHOFOVKVHRLVFH-UHFFFAOYSA-N"
"1547","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","1013.143","1012.37892561","3.72","73","9","15","3","23","218.35","C53H56N8O11S","InChI=1S/C53H56N8O11S/c62-44-16-15-43(48(64)56-44)61-51(67)40-7-4-8-42(46(40)52(61)68)54-18-25-70-27-29-72-31-30-71-28-26-69-24-17-45(63)59-22-20-58(21-23-59)39-13-11-35(12-14-39)37-9-10-38-34-60(50(66)41(38)33-37)47(36-5-2-1-3-6-36)49(65)57-53-55-19-32-73-53/h1-14,19,32-33,43,47,54H,15-18,20-31,34H2,(H,55,57,65)(H,56,62,64)","RQWUUMNUWMTZQD-UHFFFAOYSA-N"
"1548","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","1057.196","1056.40514036","3.57","76","9","16","3","26","227.58","C55H60N8O12S","InChI=1S/C55H60N8O12S/c64-46-16-15-45(50(66)58-46)63-53(69)42-7-4-8-44(48(42)54(63)70)56-18-25-72-27-29-74-31-33-75-32-30-73-28-26-71-24-17-47(65)61-22-20-60(21-23-61)41-13-11-37(12-14-41)39-9-10-40-36-62(52(68)43(40)35-39)49(38-5-2-1-3-6-38)51(67)59-55-57-19-34-76-55/h1-14,19,34-35,45,49,56H,15-18,20-33,36H2,(H,57,59,67)(H,58,64,66)","NQLZSRAQWCFGSA-UHFFFAOYSA-N"
"1549","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","897.027","896.331581496","4.62","65","9","13","3","17","182.82","C48H48N8O8S","InChI=1S/C48H48N8O8S/c57-40-16-15-39(43(58)51-40)56-46(61)36-7-4-8-38(41(36)47(56)62)49-17-24-63-26-27-64-25-23-53-19-21-54(22-20-53)35-13-11-31(12-14-35)33-9-10-34-30-55(45(60)37(34)29-33)42(32-5-2-1-3-6-32)44(59)52-48-50-18-28-65-48/h1-14,18,28-29,39,42,49H,15-17,19-27,30H2,(H,50,52,59)(H,51,57,58)","LCRBAPSWBSEBAG-UHFFFAOYSA-N"
"1550","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8O)C(=O)C7=C6)C=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","958.067","957.347959832","3.38","69","9","16","4","20","225.17","C49H51N9O10S","InChI=1S/C49H51N9O10S/c59-39-7-2-1-4-34(39)43(45(62)54-49-51-15-27-69-49)57-30-33-9-8-31(28-36(33)46(57)63)32-10-12-40(52-29-32)56-18-16-55(17-19-56)20-22-67-24-26-68-25-23-66-21-14-50-37-6-3-5-35-42(37)48(65)58(47(35)64)38-11-13-41(60)53-44(38)61/h1-10,12,15,27-29,38,43,50,59H,11,13-14,16-26,30H2,(H,51,54,62)(H,53,60,61)","JTOYENRLVILXMD-UHFFFAOYSA-N"
"1551","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","898.015","897.326830464","3.33","65","9","14","3","17","195.71","C47H47N9O8S","InChI=1S/C47H47N9O8S/c57-40-13-11-38(42(58)51-40)56-45(61)35-10-9-34(27-37(35)46(56)62)48-14-21-63-23-24-64-22-20-53-16-18-54(19-17-53)39-12-8-32(28-50-39)31-6-7-33-29-55(44(60)36(33)26-31)41(30-4-2-1-3-5-30)43(59)52-47-49-15-25-65-47/h1-10,12,15,25-28,38,41,48H,11,13-14,16-24,29H2,(H,49,52,59)(H,51,57,58)","QHQDVRLNEVZTFS-UHFFFAOYSA-N"
"1552","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","942.068","941.353045212","3.18","68","9","15","3","20","204.94","C49H51N9O9S","InChI=1S/C49H51N9O9S/c59-42-13-11-40(44(60)53-42)58-47(63)37-10-9-36(29-39(37)48(58)64)50-14-21-65-23-25-67-26-24-66-22-20-55-16-18-56(19-17-55)41-12-8-34(30-52-41)33-6-7-35-31-57(46(62)38(35)28-33)43(32-4-2-1-3-5-32)45(61)54-49-51-15-27-68-49/h1-10,12,15,27-30,40,43,50H,11,13-14,16-26,31H2,(H,51,54,61)(H,53,59,60)","SSCWZTSBNMMURN-UHFFFAOYSA-N"
"1553","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(OCCOCCOCCOCCN4CCN(C5=CC=C(C6=CC=C7CN(C(C(=O)NC8=NC=CS8)C8=CC=CC=C8)C(=O)C7=C6)C=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2070","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","943.052","942.3370608","3.17","68","9","15","2","20","202.14","C49H50N8O10S","InChI=1S/C49H50N8O10S/c58-41-14-12-38(44(59)52-41)57-47(62)36-7-4-8-39(42(36)48(57)63)67-27-26-66-25-24-65-23-22-64-21-20-54-16-18-55(19-17-54)40-13-11-34(30-51-40)33-9-10-35-31-56(46(61)37(35)29-33)43(32-5-2-1-3-6-32)45(60)53-49-50-15-28-68-49/h1-11,13,15,28-30,38,43H,12,14,16-27,31H2,(H,50,53,60)(H,52,58,59)","WWOKCOMOIMLOBV-UHFFFAOYSA-N"
"1554","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCN3CCN(C4=CC=C(C5=CC=C6CN(C(C(=O)NC7=NC=CS7)C7=CC=CC=C7)C(=O)C6=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","1083.351","1082.45065107","5.46","77","9","15","4","21","211.76","C57H66N10O8S2","InChI=1S/C57H66N10O8S2/c1-37-50(77-36-61-37)40-12-10-38(11-13-40)32-60-52(70)46-31-44(68)35-66(46)55(73)51(57(2,3)4)62-48(69)18-25-74-27-28-75-26-24-64-20-22-65(23-21-64)47-17-16-42(33-59-47)41-14-15-43-34-67(54(72)45(43)30-41)49(39-8-6-5-7-9-39)53(71)63-56-58-19-29-76-56/h5-17,19,29-30,33,36,44,46,49,51,68H,18,20-28,31-32,34-35H2,1-4H3,(H,60,70)(H,62,69)(H,58,63,71)/t44-,46+,49?,51-/m1/s1","BJESFCSPXPZXNP-ZSIHQRNSSA-N"
"1555","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCN3CCN(C4=CC=C(C5=CC=C6CN(C(C(=O)NC7=NC=CS7)C7=CC=CC=C7)C(=O)C6=C5)C=N4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of L858R/T790M EGFR-Ba/F3 cells","","","","","","","","","","","","","","","10.1002/anie.202003500","1127.404","1126.47686582","5.32","80","9","16","4","24","220.99","C59H70N10O9S2","InChI=1S/C59H70N10O9S2/c1-39-52(80-38-63-39)42-12-10-40(11-13-42)34-62-54(72)48-33-46(70)37-68(48)57(75)53(59(2,3)4)64-50(71)18-25-76-27-29-78-30-28-77-26-24-66-20-22-67(23-21-66)49-17-16-44(35-61-49)43-14-15-45-36-69(56(74)47(45)32-43)51(41-8-6-5-7-9-41)55(73)65-58-60-19-31-79-58/h5-17,19,31-32,35,38,46,48,51,53,70H,18,20-30,33-34,36-37H2,1-4H3,(H,62,72)(H,64,71)(H,60,65,73)/t46-,48+,51?,53-/m1/s1","KPMNKWKMJWXUGN-RLMRRVSWSA-N"
"1556","P10275","AR","CRBN","","","CC(O)(COC1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1)C(=O)NC1=CC=C(C#N)C(C(F)(F)F)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00194","812.751","812.251657348","2.34","58","5","13","3","20","212.05","C39H39F3N4O12","InChI=1S/C39H39F3N4O12/c1-38(52,37(51)44-25-6-5-24(22-43)29(21-25)39(40,41)42)23-58-27-9-7-26(8-10-27)56-19-17-54-15-13-53-14-16-55-18-20-57-31-4-2-3-28-33(31)36(50)46(35(28)49)30-11-12-32(47)45-34(30)48/h2-10,21,30,52H,11-20,23H2,1H3,(H,44,51)(H,45,47,48)","YBUGJPSHLSZKIC-UHFFFAOYSA-N"
"1557","P10275","AR","CRBN","","","CC(O)(COC1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2CN([C@H]2CCC(=O)NC2=O)C3=O)C=C1)C(=O)NC1=CC=C(C#N)C(C(F)(F)F)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00194","798.768","798.272392792","2.39","57","5","12","3","20","194.98","C39H41F3N4O11","InChI=1S/C39H41F3N4O11/c1-38(51,37(50)44-26-6-5-25(22-43)31(21-26)39(40,41)42)24-57-28-9-7-27(8-10-28)55-19-17-53-15-13-52-14-16-54-18-20-56-33-4-2-3-29-30(33)23-46(36(29)49)32-11-12-34(47)45-35(32)48/h2-10,21,32,51H,11-20,23-24H2,1H3,(H,44,50)(H,45,47,48)/t32-,38?/m0/s1","WXTXTGAJJSPHBT-MDYKADOQSA-N"
"1558","P10275","AR","CRBN","","","CN1C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=O)C1(C)C1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00194","821.762","821.251991696","2.76","59","6","12","1","17","194.11","C40H38F3N5O11","InChI=1S/C40H38F3N5O11/c1-39(37(53)47(38(54)46(39)2)26-9-6-24(23-44)29(22-26)40(41,42)43)25-7-10-27(11-8-25)58-20-18-56-16-14-55-15-17-57-19-21-59-31-5-3-4-28-33(31)36(52)48(35(28)51)30-12-13-32(49)45-34(30)50/h3-11,22,30H,12-21H2,1-2H3,(H,45,49,50)","KUEVRVOQPNNRMD-UHFFFAOYSA-N"
"1559","P10275","AR","CRBN","","","CN1C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=O)C1(C)C1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2CN([C@H]2CCC(=O)NC2=O)C3=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00194","807.779","807.27272714","2.82","58","6","11","1","17","177.04","C40H40F3N5O10","InChI=1S/C40H40F3N5O10/c1-39(37(52)48(38(53)46(39)2)27-9-6-25(23-44)31(22-27)40(41,42)43)26-7-10-28(11-8-26)57-20-18-55-16-14-54-15-17-56-19-21-58-33-5-3-4-29-30(33)24-47(36(29)51)32-12-13-34(49)45-35(32)50/h3-11,22,32H,12-21,24H2,1-2H3,(H,45,49,50)/t32-,39?/m0/s1","YDVIYZOBGOZUAN-DKHGMYDOSA-N"
"1560","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","1.7","Compounds were administered at 10000 nM and incubated for 2 h","14.1","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acsmedchemlett.0c00194","837.83","837.229148076","3.63","59","6","12","1","17","177.04","C40H38F3N5O10S","InChI=1S/C40H38F3N5O10S/c1-39(2)37(53)46(26-7-6-24(23-44)29(22-26)40(41,42)43)38(59)48(39)25-8-10-27(11-9-25)57-20-18-55-16-14-54-15-17-56-19-21-58-31-5-3-4-28-33(31)36(52)47(35(28)51)30-12-13-32(49)45-34(30)50/h3-11,22,30H,12-21H2,1-2H3,(H,45,49,50)","AWZDAIQLULBEES-UHFFFAOYSA-N"
"1561","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(OCCOCCOCCOCCOC2=CC=CC3=C2CN([C@H]2CCC(=O)NC2=O)C3=O)C=C1","10","33","Degradation of AR in LNCaP cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00194","823.847","823.24988352","3.68","58","6","11","1","17","159.97","C40H40F3N5O9S","InChI=1S/C40H40F3N5O9S/c1-39(2)37(52)47(27-7-6-25(23-44)31(22-27)40(41,42)43)38(58)48(39)26-8-10-28(11-9-26)56-20-18-54-16-14-53-15-17-55-19-21-57-33-5-3-4-29-30(33)24-46(36(29)51)32-12-13-34(49)45-35(32)50/h3-11,22,32H,12-21,24H2,1-2H3,(H,45,49,50)/t32-/m0/s1","OHIHMSVOYVOFIW-YTTGMZPUSA-N"
"1562","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","25","IC50 was assessed using a radio-ligand displacement assay","","","","","11","Ki was assessed using a radio-ligand displacement assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","<2.7","Compounds were administered at 10000 nM and incubated for 2 h","1.4","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acsmedchemlett.0c00194","1006.183","1005.37403848","7.09","70","6","12","3","20","186.66","C50H58F3N7O8S2","InChI=1S/C50H58F3N7O8S2/c1-31-42(70-30-56-31)33-12-10-32(11-13-33)27-55-44(63)40-25-37(61)28-58(40)45(64)43(48(2,3)4)57-41(62)29-67-22-9-21-66-20-7-8-23-68-38-18-16-35(17-19-38)60-47(69)59(46(65)49(60,5)6)36-15-14-34(26-54)39(24-36)50(51,52)53/h10-19,24,30,37,40,43,61H,7-9,20-23,25,27-29H2,1-6H3,(H,55,63)(H,57,62)/t37-,40+,43-/m1/s1","UYAKVNKOLXEIRY-AKCINUCUSA-N"
"1563","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC(F)(F)C(F)(F)C(F)(F)COCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","0.26","Compounds were administered at 10000 nM and incubated for 2 h","<0.79","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acsmedchemlett.0c00194","1128.15","1127.33315767","8.39","77","6","12","3","21","186.66","C51H54F9N7O8S2","InChI=1S/C51H54F9N7O8S2/c1-29-40(77-28-63-29)31-10-8-30(9-11-31)23-62-42(70)38-21-35(68)24-65(38)43(71)41(46(2,3)4)64-39(69)25-74-27-49(54,55)51(59,60)48(52,53)26-73-18-7-19-75-36-16-14-33(15-17-36)67-45(76)66(44(72)47(67,5)6)34-13-12-32(22-61)37(20-34)50(56,57)58/h8-17,20,28,35,38,41,68H,7,18-19,21,23-27H2,1-6H3,(H,62,70)(H,64,69)/t35-,38+,41-/m1/s1","YQJIYEVGJLJDLM-LFHXYJAASA-N"
"1564","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","<0.69","Compounds were administered at 10000 nM and incubated for 2 h","8.6","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acsmedchemlett.0c00194","1022.182","1021.3689531","5.77","71","6","13","3","21","195.89","C50H58F3N7O9S2","InChI=1S/C50H58F3N7O9S2/c1-31-42(71-30-56-31)33-9-7-32(8-10-33)28-55-44(63)40-26-37(61)29-58(40)45(64)43(48(2,3)4)57-41(62)17-18-66-19-20-67-21-22-68-23-24-69-38-15-13-35(14-16-38)60-47(70)59(46(65)49(60,5)6)36-12-11-34(27-54)39(25-36)50(51,52)53/h7-16,25,30,37,40,43,61H,17-24,26,28-29H2,1-6H3,(H,55,63)(H,57,62)/t37-,40+,43-/m1/s1","AHPZKNARQBAMMU-AKCINUCUSA-N"
"1565","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOC3=CC=C(C4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","","","","","10.1021/acsmedchemlett.0c00194","1010.174","1009.34782373","8.15","71","7","11","3","16","177.43","C52H54F3N7O7S2","InChI=1S/C52H54F3N7O7S2/c1-31-44(71-30-58-31)35-10-8-32(9-11-35)27-57-46(65)42-25-39(63)28-60(42)47(66)45(50(2,3)4)59-43(64)29-68-22-7-23-69-40-20-15-34(16-21-40)33-12-17-37(18-13-33)62-49(70)61(48(67)51(62,5)6)38-19-14-36(26-56)41(24-38)52(53,54)55/h8-21,24,30,39,42,45,63H,7,22-23,25,27-29H2,1-6H3,(H,57,65)(H,59,64)/t39-,42+,45-/m1/s1","KJDKEFBHSCTTPP-BZPYCXPJSA-N"
"1566","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC(F)(F)COC3=CC=C(C4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","","","","","10.1021/acsmedchemlett.0c00194","1046.154","1045.3289801","8.46","73","7","11","3","16","177.43","C52H52F5N7O7S2","InChI=1S/C52H52F5N7O7S2/c1-30-43(73-29-60-30)34-9-7-31(8-10-34)24-59-45(67)41-22-38(65)25-62(41)46(68)44(49(2,3)4)61-42(66)26-70-27-51(53,54)28-71-39-19-14-33(15-20-39)32-11-16-36(17-12-32)64-48(72)63(47(69)50(64,5)6)37-18-13-35(23-58)40(21-37)52(55,56)57/h7-21,29,38,41,44,65H,22,24-28H2,1-6H3,(H,59,67)(H,61,66)/t38-,41+,44-/m1/s1","OZXVJHIDCIBXAC-UMWCMSNQSA-N"
"1567","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCC(F)(F)C(F)(F)COC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","<0.11","Compounds were administered at 10000 nM and incubated for 2 h","0.33","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acsmedchemlett.0c00194","1078.143","1077.33635123","7.72","74","6","12","3","20","186.66","C50H54F7N7O8S2","InChI=1S/C50H54F7N7O8S2/c1-29-40(74-28-60-29)31-10-8-30(9-11-31)23-59-42(67)38-21-35(65)24-62(38)43(68)41(46(2,3)4)61-39(66)25-70-18-7-19-71-26-48(51,52)49(53,54)27-72-36-16-14-33(15-17-36)64-45(73)63(44(69)47(64,5)6)34-13-12-32(22-58)37(20-34)50(55,56)57/h8-17,20,28,35,38,41,65H,7,18-19,21,23-27H2,1-6H3,(H,59,67)(H,61,66)/t35-,38+,41-/m1/s1","DRPPHAFHVRTMSO-LFHXYJAASA-N"
"1568","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(C(F)(F)F)=C5)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","","","","","10.1021/acsmedchemlett.0c00194","1005.17","1004.43293326","7.45","71","6","12","4","20","201.44","C52H63F3N6O9S","InChI=1S/C52H63F3N6O9S/c1-31-42(71-30-58-31)33-11-9-32(10-12-33)28-57-45(65)40-25-36(62)29-61(40)46(66)43(49(2,3)4)59-41(63)19-20-67-21-22-68-23-24-69-37-16-13-34(14-17-37)44(64)60-47-50(5,6)48(51(47,7)8)70-38-18-15-35(27-56)39(26-38)52(53,54)55/h9-18,26,30,36,40,43,47-48,62H,19-25,28-29H2,1-8H3,(H,57,65)(H,59,63)(H,60,64)/t36-,40+,43-,47-,48-/m1/s1","NPIUSCVAQUBJKH-FNMWGEBHSA-N"
"1569","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOC3=CC=C(C(=O)N[C@H]4C(C)(C)[C@H](OC5=CC=C(C#N)C(C(F)(F)F)=C5)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","11","IC50 was assessed using a radio-ligand displacement assay","","","","","5","Ki was assessed using a radio-ligand displacement assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 5 h","","","","","10.1021/acsmedchemlett.0c00194","989.171","988.438018636","8.76","70","6","11","4","19","192.21","C52H63F3N6O8S","InChI=1S/C52H63F3N6O8S/c1-31-42(70-30-58-31)33-14-12-32(13-15-33)27-57-45(65)40-24-36(62)28-61(40)46(66)43(49(2,3)4)59-41(63)29-67-22-10-9-11-23-68-37-19-16-34(17-20-37)44(64)60-47-50(5,6)48(51(47,7)8)69-38-21-18-35(26-56)39(25-38)52(53,54)55/h12-21,25,30,36,40,43,47-48,62H,9-11,22-24,27-29H2,1-8H3,(H,57,65)(H,59,63)(H,60,64)/t36-,40+,43-,47-,48-/m1/s1","PMJLFYUAIWZLAX-FNMWGEBHSA-N"
"1570","P37840","Alpha-syn","VHL","","","CNC1=CC=C(C2=NC3=CC=C(OCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3S2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","829.058","828.333890004","6.22","58","6","12","4","17","164.24","C43H52N6O7S2","InChI=1S/C43H52N6O7S2/c1-26(28-7-9-29(10-8-28)38-27(2)45-25-57-38)46-40(52)35-21-32(50)23-49(35)42(53)39(43(3,4)5)48-37(51)24-55-18-17-54-19-20-56-33-15-16-34-36(22-33)58-41(47-34)30-11-13-31(44-6)14-12-30/h7-16,22,25-26,32,35,39,44,50H,17-21,23-24H2,1-6H3,(H,46,52)(H,48,51)/t26-,32+,35-,39+/m0/s1","HEFCGIGBHUUZJR-GNAZCYGUSA-N"
"1571","P37840","Alpha-syn","VHL","","","CNC1=CC=C(C2=NC3=CC=C(OCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3S2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","961.217","960.412534248","5.77","67","6","15","4","26","191.93","C49H64N6O10S2","InChI=1S/C49H64N6O10S2/c1-32(34-7-9-35(10-8-34)44-33(2)51-31-66-44)52-46(58)41-27-38(56)29-55(41)48(59)45(49(3,4)5)54-43(57)30-64-24-23-62-20-19-60-17-18-61-21-22-63-25-26-65-39-15-16-40-42(28-39)67-47(53-40)36-11-13-37(50-6)14-12-36/h7-16,28,31-32,38,41,45,50,56H,17-27,29-30H2,1-6H3,(H,52,58)(H,54,57)/t32-,38+,41-,45+/m0/s1","RSKMHCDWHUBUGY-NLMYEZHISA-N"
"1572","P37840","Alpha-syn","VHL","","","CNC1=CC=C(C2=NC3=CC=C(OCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3S2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","1005.27","1004.438749","5.63","70","6","16","4","29","201.16","C51H68N6O11S2","InChI=1S/C51H68N6O11S2/c1-34(36-7-9-37(10-8-36)46-35(2)53-33-69-46)54-48(60)43-29-40(58)31-57(43)50(61)47(51(3,4)5)56-45(59)32-67-26-25-65-22-21-63-18-17-62-19-20-64-23-24-66-27-28-68-41-15-16-42-44(30-41)70-49(55-42)38-11-13-39(52-6)14-12-38/h7-16,30,33-34,40,43,47,52,58H,17-29,31-32H2,1-6H3,(H,54,60)(H,56,59)/t34-,40+,43-,47+/m0/s1","QABBEPRQMRXJDK-JNKORLQQSA-N"
"1573","P37840","Alpha-syn","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOC3=CC=C(CN4C(=O)/C(=C/C=C/C5=CC=C([N+](=O)[O-])C=C5)C5=CC=CC=C54)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","971.146","970.393513056","7.24","70","7","12","3","20","202.77","C53H58N6O10S","InChI=1S/C53H58N6O10S/c1-34(38-17-19-39(20-18-38)48-35(2)54-33-70-48)55-50(62)46-29-41(60)31-58(46)52(64)49(53(3,4)5)56-47(61)32-68-26-25-67-27-28-69-42-23-15-37(16-24-42)30-57-45-12-7-6-10-43(45)44(51(57)63)11-8-9-36-13-21-40(22-14-36)59(65)66/h6-24,33-34,41,46,49,60H,25-32H2,1-5H3,(H,55,62)(H,56,61)/b9-8+,44-11+/t34-,41+,46-,49+/m0/s1","CUQYZGPJZCRSOA-MFKJCPINSA-N"
"1574","P37840","Alpha-syn","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(N4CCN(CCCO[C@H]5C[C@H](OC6=CC=C7NC8=CC=C([N+](=O)[O-])C=C8SC7=C6)C5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","712.785","712.231533112","4.07","51","8","12","2","10","163.66","C36H36N6O8S","InChI=1S/C36H36N6O8S/c43-33-9-8-30(34(44)38-33)41-35(45)26-5-2-21(16-27(26)36(41)46)40-13-11-39(12-14-40)10-1-15-49-24-18-25(19-24)50-23-4-7-29-32(20-23)51-31-17-22(42(47)48)3-6-28(31)37-29/h2-7,16-17,20,24-25,30,37H,1,8-15,18-19H2,(H,38,43,44)/t24-,25-,30?","OECPJMFABVRWAQ-BIBMFLLGSA-N"
"1575","P37840","Alpha-syn","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CN3CCN(CCN4CCC(O[C@H]5C[C@H](OC6=CC=C7NC8=CC=C([N+](=O)[O-])C=C8SC7=C6)C5)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00192","1010.297","1009.4554021","6.84","71","9","15","4","16","194.98","C52H67N9O8S2","InChI=1S/C52H67N9O8S2/c1-32(34-6-8-35(9-7-34)48-33(2)53-31-70-48)54-50(64)44-25-37(62)29-60(44)51(65)49(52(3,4)5)56-47(63)30-59-22-20-58(21-23-59)19-18-57-16-14-38(15-17-57)68-40-26-41(27-40)69-39-11-13-43-46(28-39)71-45-24-36(61(66)67)10-12-42(45)55-43/h6-13,24,28,31-32,37-38,40-41,44,49,55,62H,14-23,25-27,29-30H2,1-5H3,(H,54,64)(H,56,63)/t32-,37+,40-,41-,44-,49+/m0/s1","VHYUWQJHBQNSIP-YGGGOKCSSA-N"
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"1576","Q16620","TRKB","CRBN","","CPD-053","O=C1CCC(N2C(=O)C3=CC=CC(NCCCC(=O)N4CCN(C5=CC=C(C(=O)NC6=N[NH]C7=CC=C(CC8=CC(F)=CC(F)=C8)C=C67)C(NC6CCOCC6)=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.5","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","887.945","887.356651284","5.91","65","9","11","5","13","198.17","C47H47F2N9O7","InChI=1S/C47H47F2N9O7/c48-29-22-28(23-30(49)25-29)21-27-6-9-36-35(24-27)43(55-54-36)53-44(61)33-8-7-32(26-38(33)51-31-12-19-65-20-13-31)56-15-17-57(18-16-56)41(60)5-2-14-50-37-4-1-3-34-42(37)47(64)58(46(34)63)39-10-11-40(59)52-45(39)62/h1,3-4,6-9,22-26,31,39,50-51H,2,5,10-21H2,(H,52,59,62)(H2,53,54,55,61)","XIQKGMBOWICGJW-UHFFFAOYSA-N"
"1576","Q16288","TRKC","CRBN","","CPD-053","O=C1CCC(N2C(=O)C3=CC=CC(NCCCC(=O)N4CCN(C5=CC=C(C(=O)NC6=N[NH]C7=CC=C(CC8=CC(F)=CC(F)=C8)C=C67)C(NC6CCOCC6)=C5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.5","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","887.945","887.356651284","5.91","65","9","11","5","13","198.17","C47H47F2N9O7","InChI=1S/C47H47F2N9O7/c48-29-22-28(23-30(49)25-29)21-27-6-9-36-35(24-27)43(55-54-36)53-44(61)33-8-7-32(26-38(33)51-31-12-19-65-20-13-31)56-15-17-57(18-16-56)41(60)5-2-14-50-37-4-1-3-34-42(37)47(64)58(46(34)63)39-10-11-40(59)52-45(39)62/h1,3-4,6-9,22-26,31,39,50-51H,2,5,10-21H2,(H,52,59,62)(H2,53,54,55,61)","XIQKGMBOWICGJW-UHFFFAOYSA-N"
"1577","P04629","TRKA","CRBN","","CPD-141","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C(=O)NC6=N[NH]C7=CC=C(CC8=CC(F)=CC(F)=C8)C=C67)C(NC6CCOCC6)=C5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.6","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","1050.13","1049.44586021","4.41","76","9","15","5","24","235.09","C54H61F2N9O11","InChI=1S/C54H61F2N9O11/c55-36-28-35(29-37(56)31-36)27-34-1-6-45-44(30-34)50(62-61-45)60-51(68)42-5-3-40(33-46(42)58-38-9-17-72-18-10-38)63-13-15-64(16-14-63)49(67)11-19-73-21-23-75-25-26-76-24-22-74-20-12-57-39-2-4-41-43(32-39)54(71)65(53(41)70)47-7-8-48(66)59-52(47)69/h1-6,28-33,38,47,57-58H,7-27H2,(H,59,66,69)(H2,60,61,62,68)","WZZQEDKZQHBYFG-UHFFFAOYSA-N"
"1577","Q16620","TRKB","CRBN","","CPD-141","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C(=O)NC6=N[NH]C7=CC=C(CC8=CC(F)=CC(F)=C8)C=C67)C(NC6CCOCC6)=C5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.6","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","1050.13","1049.44586021","4.41","76","9","15","5","24","235.09","C54H61F2N9O11","InChI=1S/C54H61F2N9O11/c55-36-28-35(29-37(56)31-36)27-34-1-6-45-44(30-34)50(62-61-45)60-51(68)42-5-3-40(33-46(42)58-38-9-17-72-18-10-38)63-13-15-64(16-14-63)49(67)11-19-73-21-23-75-25-26-76-24-22-74-20-12-57-39-2-4-41-43(32-39)54(71)65(53(41)70)47-7-8-48(66)59-52(47)69/h1-6,28-33,38,47,57-58H,7-27H2,(H,59,66,69)(H2,60,61,62,68)","WZZQEDKZQHBYFG-UHFFFAOYSA-N"
"1577","Q16288","TRKC","CRBN","","CPD-141","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=C(C(=O)NC6=N[NH]C7=CC=C(CC8=CC(F)=CC(F)=C8)C=C67)C(NC6CCOCC6)=C5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.6","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","1050.13","1049.44586021","4.41","76","9","15","5","24","235.09","C54H61F2N9O11","InChI=1S/C54H61F2N9O11/c55-36-28-35(29-37(56)31-36)27-34-1-6-45-44(30-34)50(62-61-45)60-51(68)42-5-3-40(33-46(42)58-38-9-17-72-18-10-38)63-13-15-64(16-14-63)49(67)11-19-73-21-23-75-25-26-76-24-22-74-20-12-57-39-2-4-41-43(32-39)54(71)65(53(41)70)47-7-8-48(66)59-52(47)69/h1-6,28-33,38,47,57-58H,7-27H2,(H,59,66,69)(H2,60,61,62,68)","WZZQEDKZQHBYFG-UHFFFAOYSA-N"
"1578","P04629","TRKA","CRBN","","CPD-145","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","799.868","799.335441664","3.02","59","9","13","3","11","177.48","C42H42FN11O5","InChI=1S/C42H42FN11O5/c43-27-5-1-4-26(22-27)32-7-3-17-52(32)37-13-12-35-46-24-34(54(35)49-37)31-6-2-8-36(47-31)51-20-18-50(19-21-51)25-39(56)45-16-15-44-28-9-10-29-30(23-28)42(59)53(41(29)58)33-11-14-38(55)48-40(33)57/h1-2,4-6,8-10,12-13,22-24,32-33,44H,3,7,11,14-21,25H2,(H,45,56)(H,48,55,57)/t32-,33?/m1/s1","VTETXVUOPFSTLY-KWRHIPAJSA-N"
"1578","Q16620","TRKB","CRBN","","CPD-145","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","799.868","799.335441664","3.02","59","9","13","3","11","177.48","C42H42FN11O5","InChI=1S/C42H42FN11O5/c43-27-5-1-4-26(22-27)32-7-3-17-52(32)37-13-12-35-46-24-34(54(35)49-37)31-6-2-8-36(47-31)51-20-18-50(19-21-51)25-39(56)45-16-15-44-28-9-10-29-30(23-28)42(59)53(41(29)58)33-11-14-38(55)48-40(33)57/h1-2,4-6,8-10,12-13,22-24,32-33,44H,3,7,11,14-21,25H2,(H,45,56)(H,48,55,57)/t32-,33?/m1/s1","VTETXVUOPFSTLY-KWRHIPAJSA-N"
"1578","Q16288","TRKC","CRBN","","CPD-145","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","799.868","799.335441664","3.02","59","9","13","3","11","177.48","C42H42FN11O5","InChI=1S/C42H42FN11O5/c43-27-5-1-4-26(22-27)32-7-3-17-52(32)37-13-12-35-46-24-34(54(35)49-37)31-6-2-8-36(47-31)51-20-18-50(19-21-51)25-39(56)45-16-15-44-28-9-10-29-30(23-28)42(59)53(41(29)58)33-11-14-38(55)48-40(33)57/h1-2,4-6,8-10,12-13,22-24,32-33,44H,3,7,11,14-21,25H2,(H,45,56)(H,48,55,57)/t32-,33?/m1/s1","VTETXVUOPFSTLY-KWRHIPAJSA-N"
"1579","P04629","TRKA","CRBN","","CPD-181","O=C1CCC(N2C(=O)C3=CC=C(NCCN4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.4","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","742.816","742.313977948","3.68","55","9","12","2","9","148.38","C40H39FN10O4","InChI=1S/C40H39FN10O4/c41-26-5-1-4-25(22-26)31-7-3-16-49(31)36-13-12-34-43-24-33(51(34)46-36)30-6-2-8-35(44-30)48-20-18-47(19-21-48)17-15-42-27-9-10-28-29(23-27)40(55)50(39(28)54)32-11-14-37(52)45-38(32)53/h1-2,4-6,8-10,12-13,22-24,31-32,42H,3,7,11,14-21H2,(H,45,52,53)/t31-,32?/m1/s1","APRUIDKBAJQJRN-XGDNGBMYSA-N"
"1579","Q16620","TRKB","CRBN","","CPD-181","O=C1CCC(N2C(=O)C3=CC=C(NCCN4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.4","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","742.816","742.313977948","3.68","55","9","12","2","9","148.38","C40H39FN10O4","InChI=1S/C40H39FN10O4/c41-26-5-1-4-25(22-26)31-7-3-16-49(31)36-13-12-34-43-24-33(51(34)46-36)30-6-2-8-35(44-30)48-20-18-47(19-21-48)17-15-42-27-9-10-28-29(23-27)40(55)50(39(28)54)32-11-14-37(52)45-38(32)53/h1-2,4-6,8-10,12-13,22-24,31-32,42H,3,7,11,14-21H2,(H,45,52,53)/t31-,32?/m1/s1","APRUIDKBAJQJRN-XGDNGBMYSA-N"
"1579","Q16288","TRKC","CRBN","","CPD-181","O=C1CCC(N2C(=O)C3=CC=C(NCCN4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.4","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","742.816","742.313977948","3.68","55","9","12","2","9","148.38","C40H39FN10O4","InChI=1S/C40H39FN10O4/c41-26-5-1-4-25(22-26)31-7-3-16-49(31)36-13-12-34-43-24-33(51(34)46-36)30-6-2-8-35(44-30)48-20-18-47(19-21-48)17-15-42-27-9-10-28-29(23-27)40(55)50(39(28)54)32-11-14-37(52)45-38(32)53/h1-2,4-6,8-10,12-13,22-24,31-32,42H,3,7,11,14-21H2,(H,45,52,53)/t31-,32?/m1/s1","APRUIDKBAJQJRN-XGDNGBMYSA-N"
"1580","P04629","TRKA","CRBN","","CPD-085","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.8","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","3.43","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-6-1-5-28(25-29)33-10-4-18-54(33)38-14-13-36-48-26-35(56(36)51-38)31-8-3-11-37(49-31)53-21-19-52(20-22-53)27-40(58)47-17-24-62-23-16-46-32-9-2-7-30-41(32)44(61)55(43(30)60)34-12-15-39(57)50-42(34)59/h1-3,5-9,11,13-14,25-26,33-34,46H,4,10,12,15-24,27H2,(H,47,58)(H,50,57,59)/t33-,34?/m1/s1","FFBYSKPSTCKKSY-BONSOQDYSA-N"
"1580","Q16620","TRKB","CRBN","","CPD-085","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.8","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","3.43","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-6-1-5-28(25-29)33-10-4-18-54(33)38-14-13-36-48-26-35(56(36)51-38)31-8-3-11-37(49-31)53-21-19-52(20-22-53)27-40(58)47-17-24-62-23-16-46-32-9-2-7-30-41(32)44(61)55(43(30)60)34-12-15-39(57)50-42(34)59/h1-3,5-9,11,13-14,25-26,33-34,46H,4,10,12,15-24,27H2,(H,47,58)(H,50,57,59)/t33-,34?/m1/s1","FFBYSKPSTCKKSY-BONSOQDYSA-N"
"1580","Q16288","TRKC","CRBN","","CPD-085","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.8","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","3.43","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-6-1-5-28(25-29)33-10-4-18-54(33)38-14-13-36-48-26-35(56(36)51-38)31-8-3-11-37(49-31)53-21-19-52(20-22-53)27-40(58)47-17-24-62-23-16-46-32-9-2-7-30-41(32)44(61)55(43(30)60)34-12-15-39(57)50-42(34)59/h1-3,5-9,11,13-14,25-26,33-34,46H,4,10,12,15-24,27H2,(H,47,58)(H,50,57,59)/t33-,34?/m1/s1","FFBYSKPSTCKKSY-BONSOQDYSA-N"
"1581","P04629","TRKA","CRBN","","CPD-143","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","2.88","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-5-1-4-28(24-29)34-7-3-17-54(34)39-13-12-37-48-26-36(56(37)51-39)33-6-2-8-38(49-33)53-20-18-52(19-21-53)27-41(58)47-16-23-62-22-15-46-30-9-10-31-32(25-30)44(61)55(43(31)60)35-11-14-40(57)50-42(35)59/h1-2,4-6,8-10,12-13,24-26,34-35,46H,3,7,11,14-23,27H2,(H,47,58)(H,50,57,59)/t34-,35?/m1/s1","WKCSJTXSYCNHBY-IFDNYZKCSA-N"
"1581","Q16620","TRKB","CRBN","","CPD-143","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","2.88","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-5-1-4-28(24-29)34-7-3-17-54(34)39-13-12-37-48-26-36(56(37)51-39)33-6-2-8-38(49-33)53-20-18-52(19-21-53)27-41(58)47-16-23-62-22-15-46-30-9-10-31-32(25-30)44(61)55(43(31)60)35-11-14-40(57)50-42(35)59/h1-2,4-6,8-10,12-13,24-26,34-35,46H,3,7,11,14-23,27H2,(H,47,58)(H,50,57,59)/t34-,35?/m1/s1","WKCSJTXSYCNHBY-IFDNYZKCSA-N"
"1581","Q16288","TRKC","CRBN","","CPD-143","O=C(CN1CCN(C2=CC=CC(C3=CN=C4C=CC(N5CCC[C@@H]5C5=CC=CC(F)=C5)=NN34)=N2)CC1)NCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","843.921","843.361656412","2.88","62","9","14","3","14","186.71","C44H46FN11O6","InChI=1S/C44H46FN11O6/c45-29-5-1-4-28(24-29)34-7-3-17-54(34)39-13-12-37-48-26-36(56(37)51-39)33-6-2-8-38(49-33)53-20-18-52(19-21-53)27-41(58)47-16-23-62-22-15-46-30-9-10-31-32(25-30)44(61)55(43(31)60)35-11-14-40(57)50-42(35)59/h1-2,4-6,8-10,12-13,24-26,34-35,46H,3,7,11,14-23,27H2,(H,47,58)(H,50,57,59)/t34-,35?/m1/s1","WKCSJTXSYCNHBY-IFDNYZKCSA-N"
"1582","P04629","TRKA","CRBN","","CPD-159","O=C1CCC(N2C(=O)C3=CC=C(NCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","798.88","798.340192696","3.79","59","9","12","2","11","165.45","C43H43FN10O5","InChI=1S/C43H43FN10O5/c44-28-7-3-6-27(24-28)33-9-5-19-52(33)38-16-15-36-46-26-35(54(36)49-38)32-8-4-10-37(47-32)50-20-22-51(23-21-50)40(56)11-1-2-18-45-29-12-13-30-31(25-29)43(59)53(42(30)58)34-14-17-39(55)48-41(34)57/h3-4,6-8,10,12-13,15-16,24-26,33-34,45H,1-2,5,9,11,14,17-23H2,(H,48,55,57)/t33-,34?/m1/s1","ATSQWPUJIXUSHQ-BONSOQDYSA-N"
"1582","Q16620","TRKB","CRBN","","CPD-159","O=C1CCC(N2C(=O)C3=CC=C(NCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","798.88","798.340192696","3.79","59","9","12","2","11","165.45","C43H43FN10O5","InChI=1S/C43H43FN10O5/c44-28-7-3-6-27(24-28)33-9-5-19-52(33)38-16-15-36-46-26-35(54(36)49-38)32-8-4-10-37(47-32)50-20-22-51(23-21-50)40(56)11-1-2-18-45-29-12-13-30-31(25-29)43(59)53(42(30)58)34-14-17-39(55)48-41(34)57/h3-4,6-8,10,12-13,15-16,24-26,33-34,45H,1-2,5,9,11,14,17-23H2,(H,48,55,57)/t33-,34?/m1/s1","ATSQWPUJIXUSHQ-BONSOQDYSA-N"
"1582","Q16288","TRKC","CRBN","","CPD-159","O=C1CCC(N2C(=O)C3=CC=C(NCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","798.88","798.340192696","3.79","59","9","12","2","11","165.45","C43H43FN10O5","InChI=1S/C43H43FN10O5/c44-28-7-3-6-27(24-28)33-9-5-19-52(33)38-16-15-36-46-26-35(54(36)49-38)32-8-4-10-37(47-32)50-20-22-51(23-21-50)40(56)11-1-2-18-45-29-12-13-30-31(25-29)43(59)53(42(30)58)34-14-17-39(55)48-41(34)57/h3-4,6-8,10,12-13,15-16,24-26,33-34,45H,1-2,5,9,11,14,17-23H2,(H,48,55,57)/t33-,34?/m1/s1","ATSQWPUJIXUSHQ-BONSOQDYSA-N"
"1583","P04629","TRKA","CRBN","","CPD-211","O=C1CCC(N2C(=O)C3=CC=C(N4CC(C(=O)N5CCN(C6=CC=CC(C7=CN=C8C=CC(N9CCC[C@@H]9C9=CC=CC(F)=C9)=NN78)=N6)CC5)C4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","782.837","782.308892568","3.02","58","10","12","1","7","156.66","C42H39FN10O5","InChI=1S/C42H39FN10O5/c43-27-5-1-4-25(20-27)32-7-3-15-51(32)37-13-12-35-44-22-34(53(35)47-37)31-6-2-8-36(45-31)48-16-18-49(19-17-48)40(56)26-23-50(24-26)28-9-10-29-30(21-28)42(58)52(41(29)57)33-11-14-38(54)46-39(33)55/h1-2,4-6,8-10,12-13,20-22,26,32-33H,3,7,11,14-19,23-24H2,(H,46,54,55)/t32-,33?/m1/s1","KBDADBOMDMRDQP-KWRHIPAJSA-N"
"1583","Q16620","TRKB","CRBN","","CPD-211","O=C1CCC(N2C(=O)C3=CC=C(N4CC(C(=O)N5CCN(C6=CC=CC(C7=CN=C8C=CC(N9CCC[C@@H]9C9=CC=CC(F)=C9)=NN78)=N6)CC5)C4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","782.837","782.308892568","3.02","58","10","12","1","7","156.66","C42H39FN10O5","InChI=1S/C42H39FN10O5/c43-27-5-1-4-25(20-27)32-7-3-15-51(32)37-13-12-35-44-22-34(53(35)47-37)31-6-2-8-36(45-31)48-16-18-49(19-17-48)40(56)26-23-50(24-26)28-9-10-29-30(21-28)42(58)52(41(29)57)33-11-14-38(54)46-39(33)55/h1-2,4-6,8-10,12-13,20-22,26,32-33H,3,7,11,14-19,23-24H2,(H,46,54,55)/t32-,33?/m1/s1","KBDADBOMDMRDQP-KWRHIPAJSA-N"
"1583","Q16288","TRKC","CRBN","","CPD-211","O=C1CCC(N2C(=O)C3=CC=C(N4CC(C(=O)N5CCN(C6=CC=CC(C7=CN=C8C=CC(N9CCC[C@@H]9C9=CC=CC(F)=C9)=NN78)=N6)CC5)C4)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Cell viability was determined using CellTiter-Glo assay kit","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00235","782.837","782.308892568","3.02","58","10","12","1","7","156.66","C42H39FN10O5","InChI=1S/C42H39FN10O5/c43-27-5-1-4-25(20-27)32-7-3-15-51(32)37-13-12-35-44-22-34(53(35)47-37)31-6-2-8-36(45-31)48-16-18-49(19-17-48)40(56)26-23-50(24-26)28-9-10-29-30(21-28)42(58)52(41(29)57)33-11-14-38(54)46-39(33)55/h1-2,4-6,8-10,12-13,20-22,26,32-33H,3,7,11,14-19,23-24H2,(H,46,54,55)/t32-,33?/m1/s1","KBDADBOMDMRDQP-KWRHIPAJSA-N"
"1584","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCCOC3=CC=C(N4C(=S)N(C5=CN=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/51-70","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1021.198","1020.38493751","6.71","71","6","13","3","21","199.55","C50H59F3N8O8S2","InChI=1S/C50H59F3N8O8S2/c1-31-42(71-30-57-31)33-13-11-32(12-14-33)26-56-44(64)40-24-36(62)28-59(40)45(65)43(48(2,3)4)58-41(63)29-68-21-10-20-67-19-8-7-9-22-69-37-17-15-34(16-18-37)61-47(70)60(46(66)49(61,5)6)35-23-38(50(51,52)53)39(25-54)55-27-35/h11-18,23,27,30,36,40,43,62H,7-10,19-22,24,26,28-29H2,1-6H3,(H,56,64)(H,58,63)/t36-,40+,43-/m1/s1","SGTVGCRQPJCKNZ-QIWIAYTASA-N"
"1585","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3F)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/51-70","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1052.227","1051.39591679","7.95","73","6","12","3","21","186.66","C52H61F4N7O8S2","InChI=1S/C52H61F4N7O8S2/c1-31(33-12-14-34(15-13-33)44-32(2)58-30-73-44)59-46(66)41-26-38(64)28-61(41)47(67)45(50(3,4)5)60-43(65)29-70-22-11-21-69-20-9-8-10-23-71-42-19-18-37(25-40(42)53)63-49(72)62(48(68)51(63,6)7)36-17-16-35(27-57)39(24-36)52(54,55)56/h12-19,24-25,30-31,38,41,45,64H,8-11,20-23,26,28-29H2,1-7H3,(H,59,66)(H,60,65)/t31-,38+,41-,45+/m0/s1","FLLKKIZFEMVEEL-OZSPHOIVSA-N"
"1586","P10275","AR","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCCOC3=C(F)C=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3F)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/51-70","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1070.217","1069.38649498","8.05","74","6","12","3","21","186.66","C52H60F5N7O8S2","InChI=1S/C52H60F5N7O8S2/c1-30(32-12-14-33(15-13-32)44-31(2)59-29-74-44)60-46(67)41-25-37(65)27-62(41)47(68)45(50(3,4)5)61-42(66)28-71-20-11-19-70-18-9-8-10-21-72-43-39(53)23-36(24-40(43)54)64-49(73)63(48(69)51(64,6)7)35-17-16-34(26-58)38(22-35)52(55,56)57/h12-17,22-24,29-30,37,41,45,65H,8-11,18-21,25,27-28H2,1-7H3,(H,60,67)(H,61,66)/t30-,37+,41-,45+/m0/s1","DKNBVZGJLBYCQJ-YCDRFOERSA-N"
"1587","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3F)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/>=71","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1024.173","1023.36461666","7.19","71","6","12","3","20","186.66","C50H57F4N7O8S2","InChI=1S/C50H57F4N7O8S2/c1-30-42(71-29-57-30)32-12-10-31(11-13-32)26-56-44(64)39-24-36(62)27-59(39)45(65)43(48(2,3)4)58-41(63)28-68-20-9-19-67-18-7-8-21-69-40-17-16-35(23-38(40)51)61-47(70)60(46(66)49(61,5)6)34-15-14-33(25-55)37(22-34)50(52,53)54/h10-17,22-23,29,36,39,43,62H,7-9,18-21,24,26-28H2,1-6H3,(H,56,64)(H,58,63)/t36-,39+,43-/m1/s1","HVIFXYXSTAVNJM-IPQHXDNUSA-N"
"1588","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCOC3=CC=C(N4C(=S)N(C5=CN=C(C#N)C(C(F)(F)F)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/>=71","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1007.171","1006.36928744","6.35","70","6","13","3","20","199.55","C49H57F3N8O8S2","InChI=1S/C49H57F3N8O8S2/c1-30-41(70-29-56-30)32-12-10-31(11-13-32)25-55-43(63)39-23-35(61)27-58(39)44(64)42(47(2,3)4)57-40(62)28-67-20-9-19-66-18-7-8-21-68-36-16-14-33(15-17-36)60-46(69)59(45(65)48(60,5)6)34-22-37(49(50,51)52)38(24-53)54-26-34/h10-17,22,26,29,35,39,42,61H,7-9,18-21,23,25,27-28H2,1-6H3,(H,55,63)(H,57,62)/t35-,39+,42-/m1/s1","QRYUVTSBJUTMOL-DCFQOXSYSA-N"
"1589","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCOC3=CC=C(N4C(=S)N(C5=CC=C(C#N)C(Cl)=C5)C(=O)C4(C)C)C=C3)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/>=71","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","972.631","971.347681496","6.83","67","6","12","3","20","186.66","C49H58ClN7O8S2","InChI=1S/C49H58ClN7O8S2/c1-31-42(67-30-53-31)33-12-10-32(11-13-33)27-52-44(60)40-25-37(58)28-55(40)45(61)43(48(2,3)4)54-41(59)29-64-22-9-21-63-20-7-8-23-65-38-18-16-35(17-19-38)57-47(66)56(46(62)49(57,5)6)36-15-14-34(26-51)39(50)24-36/h10-19,24,30,37,40,43,58H,7-9,20-23,25,27-29H2,1-6H3,(H,52,60)(H,54,59)/t37-,40+,43-/m1/s1","HTGWWWOBPGTSLC-AKCINUCUSA-N"
"1590","P10275","AR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCCCOC3=CC=C(C4=CC=C(N5C(=S)N(C6=CC=C(C#N)C(C(F)(F)F)=C6)C(=O)C5(C)C)C=C4)C=C3)C(C)(C)C)C=C2)SC=N1","<=50/<=50",">=71/>=71","Degradation of AR in LNCaP/VCaP cells using ELISA assay (DC50: 15min, Dmax: 4h)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00236","1082.281","1081.4053386","8.72","76","7","12","3","21","186.66","C56H62F3N7O8S2","InChI=1S/C56H62F3N7O8S2/c1-35-48(76-34-62-35)39-12-10-36(11-13-39)31-61-50(69)46-29-43(67)32-64(46)51(70)49(54(2,3)4)63-47(68)33-73-26-9-25-72-24-7-8-27-74-44-22-17-38(18-23-44)37-14-19-41(20-15-37)66-53(75)65(52(71)55(66,5)6)42-21-16-40(30-60)45(28-42)56(57,58)59/h10-23,28,34,43,46,49,67H,7-9,24-27,29,31-33H2,1-6H3,(H,61,69)(H,63,68)/t43-,46+,49-/m1/s1","IACCNUDTPQOEHL-YWIAGSDQSA-N"
"1591","O60885","BRD4","RNF114","","XH1","COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](C4=C(C5=CC=C(C(=O)NCCOCCOCCOCCNC(=O)C[C@@H]6N=C(C7=CC=C(Cl)C=C7)C7=C(SC(C)=C7C)N7C(C)=NN=C67)C=C5)OC=C4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0304-8","1143.757","1142.42262026","5.73","81","11","17","2","20","221.0","C61H67ClN6O12S","InChI=1S/C61H67ClN6O12S/c1-32-34(3)81-57-48(32)50(36-13-15-39(62)16-14-36)65-42(55-67-66-35(4)68(55)57)30-46(70)63-20-23-75-25-27-77-28-26-76-24-21-64-56(72)38-11-9-37(10-12-38)51-40(18-22-78-51)41-29-43-49(33(41)2)61(7)44(31-47(71)74-8)60(6)45(69)17-19-59(5)53(60)52(54(61)79-43)80-58(59)73/h9-19,22,41-44,52-54H,20-21,23-31H2,1-8H3,(H,63,70)(H,64,72)/t41-,42+,43-,44-,52-,53+,54-,59-,60+,61-/m1/s1","VYNDSTZRZJDPTE-ZVWHKAQLSA-N"
"1592","O60885","BRD4","RNF114","","XH2","COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](C4=C(C5=CC=C(C(=O)NCCCNC(=O)C[C@@H]6N=C(C7=CC=C(Cl)C=C7)C7=C(SC(C)=C7C)N7C(C)=NN=C67)C=C5)OC=C4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23","","","","","","","","","","","","","","","","","","","","","","240","Gel-based ABPP analysis of XH2 against RNF114","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-019-0304-8","1025.625","1024.35962608","6.53","73","11","14","2","12","193.31","C56H57ClN6O9S","InChI=1S/C56H57ClN6O9S/c1-27-29(3)73-52-43(27)45(31-14-16-34(57)17-15-31)60-37(50-62-61-30(4)63(50)52)25-41(65)58-21-9-22-59-51(67)33-12-10-32(11-13-33)46-35(19-23-70-46)36-24-38-44(28(36)2)56(7)39(26-42(66)69-8)55(6)40(64)18-20-54(5)48(55)47(49(56)71-38)72-53(54)68/h10-20,23,36-39,47-49H,9,21-22,24-26H2,1-8H3,(H,58,65)(H,59,67)/t36-,37+,38-,39-,47-,48+,49-,54-,55+,56-/m1/s1","ZXEGZGQJIKUAAS-XZGJJXKASA-N"
"1593","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","30000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","216","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","81000/68000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","652.712","652.275780872","2.67","48","6","11","3","11","177.39","C34H36N8O6","InChI=1S/C34H36N8O6/c1-19-10-12-22(13-11-19)42-21(3)28-20(2)38-40(34(48)30(28)39-42)18-5-9-26(43)36-17-6-16-35-24-8-4-7-23-29(24)33(47)41(32(23)46)25-14-15-27(44)37-31(25)45/h4,7-8,10-13,25,35H,5-6,9,14-18H2,1-3H3,(H,36,43)(H,37,44,45)","JEEWMQSGYNEVAR-UHFFFAOYSA-N"
"1594","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","25000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","30","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","76000/51000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","666.739","666.291430936","3.02","49","6","11","3","12","177.39","C35H38N8O6","InChI=1S/C35H38N8O6/c1-20-11-13-23(14-12-20)43-22(3)29-21(2)39-41(35(49)31(29)40-43)19-7-10-27(44)37-18-5-4-17-36-25-9-6-8-24-30(25)34(48)42(33(24)47)26-15-16-28(45)38-32(26)46/h6,8-9,11-14,26,36H,4-5,7,10,15-19H2,1-3H3,(H,37,44)(H,38,45,46)","QAIXUYJWVALFLV-UHFFFAOYSA-N"
"1595","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","22000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","29","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17000/32000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","680.766","680.307081","3.38","50","6","11","3","13","177.39","C36H40N8O6","InChI=1S/C36H40N8O6/c1-21-12-14-24(15-13-21)44-23(3)30-22(2)40-42(36(50)32(30)41-44)20-8-11-28(45)38-19-6-4-5-18-37-26-10-7-9-25-31(26)35(49)43(34(25)48)27-16-17-29(46)39-33(27)47/h7,9-10,12-15,27,37H,4-6,8,11,16-20H2,1-3H3,(H,38,45)(H,39,46,47)","JJAOWBPHOQZIJX-UHFFFAOYSA-N"
"1596","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","15000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","17","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15000/19000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","694.793","694.322731064","3.74","51","6","11","3","14","177.39","C37H42N8O6","InChI=1S/C37H42N8O6/c1-22-13-15-25(16-14-22)45-24(3)31-23(2)41-43(37(51)33(31)42-45)21-9-12-29(46)39-20-7-5-4-6-19-38-27-11-8-10-26-32(27)36(50)44(35(26)49)28-17-18-30(47)40-34(28)48/h8,10-11,13-16,28,38H,4-7,9,12,17-21H2,1-3H3,(H,39,46)(H,40,47,48)","KVPIXXSMHHXIPO-UHFFFAOYSA-N"
"1597","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","14000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","14","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12000/20000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","708.82","708.338381128","4.28","52","6","11","3","15","177.39","C38H44N8O6","InChI=1S/C38H44N8O6/c1-23-14-16-26(17-15-23)46-25(3)32-24(2)42-44(38(52)34(32)43-46)22-10-13-30(47)40-21-8-6-4-5-7-20-39-28-12-9-11-27-33(28)37(51)45(36(27)50)29-18-19-31(48)41-35(29)49/h9,11-12,14-17,29,39H,4-8,10,13,18-22H2,1-3H3,(H,40,47)(H,41,48,49)","ASYJUBLYCMRVHZ-UHFFFAOYSA-N"
"1598","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","3600","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","9","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8000/8000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","0.37","Compounds were administered at 10000 nM and incubated for 2 h","12.84","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acs.jmedchem.0c00929","722.847","722.354031192","4.82","53","6","11","3","16","177.39","C39H46N8O6","InChI=1S/C39H46N8O6/c1-24-15-17-27(18-16-24)47-26(3)33-25(2)43-45(39(53)35(33)44-47)23-11-14-31(48)41-22-9-7-5-4-6-8-21-40-29-13-10-12-28-34(29)38(52)46(37(28)51)30-19-20-32(49)42-36(30)50/h10,12-13,15-18,30,40H,4-9,11,14,19-23H2,1-3H3,(H,41,48)(H,42,49,50)","UETAXZPCBATLJC-UHFFFAOYSA-N"
"1599","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","30000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","160","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","58000/25000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","726.791","726.312560304","2.01","53","6","13","3","16","195.85","C37H42N8O8","InChI=1S/C37H42N8O8/c1-22-9-11-25(12-10-22)45-24(3)31-23(2)41-43(37(51)33(31)42-45)17-5-8-29(46)39-16-19-53-21-20-52-18-15-38-27-7-4-6-26-32(27)36(50)44(35(26)49)28-13-14-30(47)40-34(28)48/h4,6-7,9-12,28,38H,5,8,13-21H2,1-3H3,(H,39,46)(H,40,47,48)","CSOBFSQKJUVRAA-UHFFFAOYSA-N"
"1600","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCOCCOCCOCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=C(C)C3=C2C)C=C1","10000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","70","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26000/23000","Inhibit growth of SW480/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","798.898","798.37007518","2.58","58","6","14","3","21","205.08","C41H50N8O9","InChI=1S/C41H50N8O9/c1-26-11-13-29(14-12-26)49-28(3)35-27(2)45-47(41(55)37(35)46-49)19-5-10-33(50)43-18-7-21-57-23-25-58-24-22-56-20-6-17-42-31-9-4-8-30-36(31)40(54)48(39(30)53)32-15-16-34(51)44-38(32)52/h4,8-9,11-14,32,42H,5-7,10,15-25H2,1-3H3,(H,43,50)(H,44,51,52)","GIFCUWIWLNHZIP-UHFFFAOYSA-N"
"1601","O43924","PDEdelta","CRBN","","","CC1=CC=C(N2N=C3C(=O)N(CCCC(=O)NCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)N=C(C)C3=C2C)C=C1","5000","","Degradation of PDEdelta in SW480 cells after 24 h treatment","","","","","","","8","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7000","Inhibit growth of SW480 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00929","722.847","722.354031192","4.27","53","6","11","3","16","177.39","C39H46N8O6","InChI=1S/C39H46N8O6/c1-24-12-15-28(16-13-24)47-26(3)34-25(2)43-45(39(53)35(34)44-47)22-10-11-32(48)41-21-9-7-5-4-6-8-20-40-27-14-17-29-30(23-27)38(52)46(37(29)51)31-18-19-33(49)42-36(31)50/h12-17,23,31,40H,4-11,18-22H2,1-3H3,(H,41,48)(H,42,49,50)","OBUJFXGGFPXSOS-UHFFFAOYSA-N"
"1602","","BCR-ABL","CRBN","","P10lm","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1",">10000","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1","P10lm","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","916.016","915.392876288","3.39","68","9","15","4","16","229.64","C49H49N13O6","InChI=1S/C49H49N13O6/c1-31-10-15-35(27-40(31)55-49-52-20-18-38(54-49)34-5-4-19-50-28-34)53-45(65)33-13-11-32(12-14-33)29-59-23-25-60(26-24-59)43(64)9-2-6-36-30-61(58-57-36)22-21-51-39-8-3-7-37-44(39)48(68)62(47(37)67)41-16-17-42(63)56-46(41)66/h3-5,7-8,10-15,18-20,27-28,30,41,51H,2,6,9,16-17,21-26,29H2,1H3,(H,53,65)(H,52,54,55)(H,56,63,66)","SNRWLRVLHXFKNR-UHFFFAOYSA-N"
"1603","","BCR-ABL","CRBN","","P13lm","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1",">10000","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","P13lm","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","960.069","959.419091036","3.25","71","9","16","4","19","238.87","C51H53N13O7","InChI=1S/C51H53N13O7/c1-33-10-15-37(29-42(33)57-51-54-20-18-40(56-51)36-5-4-19-52-30-36)55-47(67)35-13-11-34(12-14-35)31-61-22-24-62(25-23-61)45(66)9-2-6-38-32-63(60-59-38)26-28-71-27-21-53-41-8-3-7-39-46(41)50(70)64(49(39)69)43-16-17-44(65)58-48(43)68/h3-5,7-8,10-15,18-20,29-30,32,43,53H,2,6,9,16-17,21-28,31H2,1H3,(H,55,67)(H,54,56,57)(H,58,65,68)","WEVFCVSACWLJHM-UHFFFAOYSA-N"
"1604","","BCR-ABL","CRBN","","P16lm","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1",">10000","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3","P16lm","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1004.122","1003.44530578","3.1","74","9","17","4","22","248.1","C53H57N13O8","InChI=1S/C53H57N13O8/c1-35-10-15-39(31-44(35)59-53-56-20-18-42(58-53)38-5-4-19-54-32-38)57-49(69)37-13-11-36(12-14-37)33-63-22-24-64(25-23-63)47(68)9-2-6-40-34-65(62-61-40)26-28-74-30-29-73-27-21-55-43-8-3-7-41-48(43)52(72)66(51(41)71)45-16-17-46(67)60-50(45)70/h3-5,7-8,10-15,18-20,31-32,34,45,55H,2,6,9,16-17,21-30,33H2,1H3,(H,57,69)(H,56,58,59)(H,60,67,70)","BCRKJNDKDHEKKG-UHFFFAOYSA-N"
"1605","","BCR-ABL","CRBN","","P19lm","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1",">10000","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4","P19lm","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1048.175","1047.47152053","2.95","77","9","18","4","25","257.33","C55H61N13O9","InChI=1S/C55H61N13O9/c1-37-10-15-41(33-46(37)61-55-58-20-18-44(60-55)40-5-4-19-56-34-40)59-51(71)39-13-11-38(12-14-39)35-65-22-24-66(25-23-65)49(70)9-2-6-42-36-67(64-63-42)26-28-76-30-32-77-31-29-75-27-21-57-45-8-3-7-43-50(45)54(74)68(53(43)73)47-16-17-48(69)62-52(47)72/h3-5,7-8,10-15,18-20,33-34,36,47,57H,2,6,9,16-17,21-32,35H2,1H3,(H,59,71)(H,58,60,61)(H,62,69,72)","VUQOGXGCYSGFPE-UHFFFAOYSA-N"
"1606","","BCR-ABL","CRBN","","P20lm","CC1=CC=C(NC(=O)C2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)C=C1NC1=NC=CC(C2=CC=CN=C2)=N1",">10000","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5","P20lm","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1092.228","1091.49773528","2.8","80","9","19","4","28","266.56","C57H65N13O10","InChI=1S/C57H65N13O10/c1-39-10-15-43(35-48(39)63-57-60-20-18-46(62-57)42-5-4-19-58-36-42)61-53(73)41-13-11-40(12-14-41)37-67-22-24-68(25-23-67)51(72)9-2-6-44-38-69(66-65-44)26-28-78-30-32-80-34-33-79-31-29-77-27-21-59-47-8-3-7-45-52(47)56(76)70(55(45)75)49-16-17-50(71)64-54(49)74/h3-5,7-8,10-15,18-20,35-36,38,49,59H,2,6,9,16-17,21-34,37H2,1H3,(H,61,73)(H,60,62,63)(H,64,71,74)","FVRDYNQXLKNCEW-UHFFFAOYSA-N"
"1607","","BCR-ABL","CRBN","","P10D","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)CC2)=N1","56","","Degradation of BCR-ABL in K562 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6","P10D","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","880.392","879.279024744","4.15","62","8","16","4","14","229.64","C41H42ClN13O6S","InChI=1S/C41H42ClN13O6S/c1-23-6-3-9-27(42)36(23)49-38(59)30-21-44-41(62-30)47-31-20-32(46-24(2)45-31)52-16-18-53(19-17-52)34(57)11-4-7-25-22-54(51-50-25)15-14-43-28-10-5-8-26-35(28)40(61)55(39(26)60)29-12-13-33(56)48-37(29)58/h3,5-6,8-10,20-22,29,43H,4,7,11-19H2,1-2H3,(H,49,59)(H,48,56,58)(H,44,45,46,47)","UDYKDIVYTSSTMR-UHFFFAOYSA-N"
"1608","","BCR-ABL","CRBN","","P13D","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)CC2)=N1","56","","Degradation of BCR-ABL in K562 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7","P13D","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","924.445","923.305239492","4.0","65","8","17","4","17","238.87","C43H46ClN13O7S","InChI=1S/C43H46ClN13O7S/c1-25-6-3-9-29(44)38(25)51-40(61)32-23-46-43(65-32)49-33-22-34(48-26(2)47-33)54-15-17-55(18-16-54)36(59)11-4-7-27-24-56(53-52-27)19-21-64-20-14-45-30-10-5-8-28-37(30)42(63)57(41(28)62)31-12-13-35(58)50-39(31)60/h3,5-6,8-10,22-24,31,45H,4,7,11-21H2,1-2H3,(H,51,61)(H,50,58,60)(H,46,47,48,49)","VCNRYEXPDDIZFJ-UHFFFAOYSA-N"
"1609","","BCR-ABL","CRBN","","P16D","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)CC2)=N1","20","","Degradation of BCR-ABL in K562 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8","P16D","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","968.498","967.33145424","3.85","68","8","18","4","20","248.1","C45H50ClN13O8S","InChI=1S/C45H50ClN13O8S/c1-27-6-3-9-31(46)40(27)53-42(63)34-25-48-45(68-34)51-35-24-36(50-28(2)49-35)56-15-17-57(18-16-56)38(61)11-4-7-29-26-58(55-54-29)19-21-67-23-22-66-20-14-47-32-10-5-8-30-39(32)44(65)59(43(30)64)33-12-13-37(60)52-41(33)62/h3,5-6,8-10,24-26,33,47H,4,7,11-23H2,1-2H3,(H,53,63)(H,52,60,62)(H,48,49,50,51)","POLFXDZCPIISDB-UHFFFAOYSA-N"
"1610","","BCR-ABL","CRBN","","P19D","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)CC2)=N1","56","","Degradation of BCR-ABL in K562 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9","P19D","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1012.551","1011.35766899","3.71","71","8","19","4","23","257.33","C47H54ClN13O9S","InChI=1S/C47H54ClN13O9S/c1-29-6-3-9-33(48)42(29)55-44(65)36-27-50-47(71-36)53-37-26-38(52-30(2)51-37)58-15-17-59(18-16-58)40(63)11-4-7-31-28-60(57-56-31)19-21-69-23-25-70-24-22-68-20-14-49-34-10-5-8-32-41(34)46(67)61(45(32)66)35-12-13-39(62)54-43(35)64/h3,5-6,8-10,26-28,35,49H,4,7,11-25H2,1-2H3,(H,55,65)(H,54,62,64)(H,50,51,52,53)","HBLQGFOSQLTPDJ-UHFFFAOYSA-N"
"1611","","BCR-ABL","CRBN","","P22D","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)CC2)=N1","10","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.2","Inhibit viability of K562 cells","10","P22D","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1056.604","1055.38388374","3.56","74","8","20","4","26","266.56","C49H58ClN13O10S","InChI=1S/C49H58ClN13O10S/c1-31-6-3-9-35(50)44(31)57-46(67)38-29-52-49(74-38)55-39-28-40(54-32(2)53-39)60-15-17-61(18-16-60)42(65)11-4-7-33-30-62(59-58-33)19-21-71-23-25-73-27-26-72-24-22-70-20-14-51-36-10-5-8-34-43(36)48(69)63(47(34)68)37-12-13-41(64)56-45(37)66/h3,5-6,8-10,28-30,37,51H,4,7,11-27H2,1-2H3,(H,57,67)(H,56,64,66)(H,52,53,54,55)","BCHARVWLDCVBSQ-UHFFFAOYSA-N"
"1612","","BCR-ABL","CRBN","","P10As","O=C1CCC(N2C(=O)C3=CC=CC(NCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1",">625","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11","P10As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","885.289","884.272125708","3.46","63","8","14","5","16","238.53","C41H39ClF2N12O7","InChI=1S/C41H39ClF2N12O7/c42-41(43,44)63-27-9-7-24(8-10-27)49-37(59)23-19-29(30-13-15-47-52-30)36(46-20-23)54-17-14-25(21-54)48-33(57)6-1-3-26-22-55(53-51-26)18-16-45-31-5-2-4-28-35(31)40(62)56(39(28)61)32-11-12-34(58)50-38(32)60/h2,4-5,7-10,13,15,19-20,22,25,32,45H,1,3,6,11-12,14,16-18,21H2,(H,47,52)(H,48,57)(H,49,59)(H,50,58,60)/t25-,32?/m1/s1","KHHQVHBDTLVQLY-LYYPKXFYSA-N"
"1613","","BCR-ABL","CRBN","","P13As","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1","400","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","P13As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","929.342","928.298340456","3.31","66","8","15","5","19","247.76","C43H43ClF2N12O8","InChI=1S/C43H43ClF2N12O8/c44-43(45,46)66-29-9-7-26(8-10-29)51-39(61)25-21-31(32-13-15-49-54-32)38(48-22-25)56-17-14-27(23-56)50-35(59)6-1-3-28-24-57(55-53-28)18-20-65-19-16-47-33-5-2-4-30-37(33)42(64)58(41(30)63)34-11-12-36(60)52-40(34)62/h2,4-5,7-10,13,15,21-22,24,27,34,47H,1,3,6,11-12,14,16-20,23H2,(H,49,54)(H,50,59)(H,51,61)(H,52,60,62)/t27-,34?/m1/s1","NIHYSKAIKSWAKC-RVLHTLCESA-N"
"1614","","BCR-ABL","CRBN","","P16As","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1","300","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13","P16As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","973.395","972.324555204","3.16","69","8","16","5","22","256.99","C45H47ClF2N12O9","InChI=1S/C45H47ClF2N12O9/c46-45(47,48)69-31-9-7-28(8-10-31)53-41(63)27-23-33(34-13-15-51-56-34)40(50-24-27)58-17-14-29(25-58)52-37(61)6-1-3-30-26-59(57-55-30)18-20-68-22-21-67-19-16-49-35-5-2-4-32-39(35)44(66)60(43(32)65)36-11-12-38(62)54-42(36)64/h2,4-5,7-10,13,15,23-24,26,29,36,49H,1,3,6,11-12,14,16-22,25H2,(H,51,56)(H,52,61)(H,53,63)(H,54,62,64)/t29-,36?/m1/s1","STRPXCHXMXBMQI-NDPHRHSWSA-N"
"1615","","BCR-ABL","CRBN","","P19As","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1","200","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","121","Inhibit viability of K562 cells","14","P19As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1017.448","1016.35076995","3.01","72","8","17","5","25","266.22","C47H51ClF2N12O10","InChI=1S/C47H51ClF2N12O10/c48-47(49,50)72-33-9-7-30(8-10-33)55-43(65)29-25-35(36-13-15-53-58-36)42(52-26-29)60-17-14-31(27-60)54-39(63)6-1-3-32-28-61(59-57-32)18-20-70-22-24-71-23-21-69-19-16-51-37-5-2-4-34-41(37)46(68)62(45(34)67)38-11-12-40(64)56-44(38)66/h2,4-5,7-10,13,15,25-26,28,31,38,51H,1,3,6,11-12,14,16-24,27H2,(H,53,58)(H,54,63)(H,55,65)(H,56,64,66)/t31-,38?/m1/s1","LUCAXHCIOIVJQP-LERZKORDSA-N"
"1615","","BCR-ABL T315I","CRBN","","P19As","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1020","Inhibit viability of BaF3 BCR-ABL(T315I) cells","14","P19As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1017.448","1016.35076995","3.01","72","8","17","5","25","266.22","C47H51ClF2N12O10","InChI=1S/C47H51ClF2N12O10/c48-47(49,50)72-33-9-7-30(8-10-33)55-43(65)29-25-35(36-13-15-53-58-36)42(52-26-29)60-17-14-31(27-60)54-39(63)6-1-3-32-28-61(59-57-32)18-20-70-22-24-71-23-21-69-19-16-51-37-5-2-4-34-41(37)46(68)62(45(34)67)38-11-12-40(64)56-44(38)66/h2,4-5,7-10,13,15,25-26,28,31,38,51H,1,3,6,11-12,14,16-24,27H2,(H,53,58)(H,54,63)(H,55,65)(H,56,64,66)/t31-,38?/m1/s1","LUCAXHCIOIVJQP-LERZKORDSA-N"
"1616","","BCR-ABL","CRBN","","P22As","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCN4C=C(CCCC(=O)N[C@@H]5CCN(C6=NC=C(C(=O)NC7=CC=C(OC(F)(F)Cl)C=C7)C=C6C6=N[NH]C=C6)C5)N=N4)=C3C2=O)C(=O)N1","500","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15","P22As","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1061.501","1060.3769847","2.87","75","8","18","5","28","275.45","C49H55ClF2N12O11","InChI=1S/C49H55ClF2N12O11/c50-49(51,52)75-35-9-7-32(8-10-35)57-45(67)31-27-37(38-13-15-55-60-38)44(54-28-31)62-17-14-33(29-62)56-41(65)6-1-3-34-30-63(61-59-34)18-20-72-22-24-74-26-25-73-23-21-71-19-16-53-39-5-2-4-36-43(39)48(70)64(47(36)69)40-11-12-42(66)58-46(40)68/h2,4-5,7-10,13,15,27-28,30,33,40,53H,1,3,6,11-12,14,16-26,29H2,(H,55,60)(H,56,65)(H,57,67)(H,58,66,68)/t33-,40?/m1/s1","PSIJYAOLNAWKKI-DGRXGLRRSA-N"
"1617","","BCR-ABL","CRBN","","P10P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","625","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16","P10P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","954.971","954.35371182","3.99","70","9","14","3","13","209.13","C49H45F3N12O6","InChI=1S/C49H45F3N12O6/c1-30-10-11-32(25-31(30)13-15-36-27-54-41-8-4-18-55-64(36)41)45(67)56-34-14-12-33(38(26-34)49(50,51)52)28-60-21-23-61(24-22-60)43(66)9-2-5-35-29-62(59-58-35)20-19-53-39-7-3-6-37-44(39)48(70)63(47(37)69)40-16-17-42(65)57-46(40)68/h3-4,6-8,10-12,14,18,25-27,29,40,53H,2,5,9,16-17,19-24,28H2,1H3,(H,56,67)(H,57,65,68)","VKWNMNNQSSMQIS-UHFFFAOYSA-N"
"1618","","BCR-ABL","CRBN","","P13P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","70","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17","P13P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","999.024","998.379926568","3.84","73","9","15","3","16","218.36","C51H49F3N12O7","InChI=1S/C51H49F3N12O7/c1-32-10-11-34(27-33(32)13-15-38-29-56-43-8-4-18-57-66(38)43)47(69)58-36-14-12-35(40(28-36)51(52,53)54)30-62-20-22-63(23-21-62)45(68)9-2-5-37-31-64(61-60-37)24-26-73-25-19-55-41-7-3-6-39-46(41)50(72)65(49(39)71)42-16-17-44(67)59-48(42)70/h3-4,6-8,10-12,14,18,27-29,31,42,55H,2,5,9,16-17,19-26,30H2,1H3,(H,58,69)(H,59,67,70)","VCIZNIVXZWDIOC-UHFFFAOYSA-N"
"1619","","BCR-ABL","CRBN","","P16P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","70","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18","P16P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1043.077","1042.40614132","3.7","76","9","16","3","19","227.59","C53H53F3N12O8","InChI=1S/C53H53F3N12O8/c1-34-10-11-36(29-35(34)13-15-40-31-58-45-8-4-18-59-68(40)45)49(71)60-38-14-12-37(42(30-38)53(54,55)56)32-64-20-22-65(23-21-64)47(70)9-2-5-39-33-66(63-62-39)24-26-76-28-27-75-25-19-57-43-7-3-6-41-48(43)52(74)67(51(41)73)44-16-17-46(69)61-50(44)72/h3-4,6-8,10-12,14,18,29-31,33,44,57H,2,5,9,16-17,19-28,32H2,1H3,(H,60,71)(H,61,69,72)","ZFZXSTQIIIMNAX-UHFFFAOYSA-N"
"1620","","BCR-ABL","CRBN","","P19P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","20","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.5","Inhibit viability of K562 cells","19","P19P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1087.13","1086.43235606","3.55","79","9","17","3","22","236.82","C55H57F3N12O9","InChI=1S/C55H57F3N12O9/c1-36-10-11-38(31-37(36)13-15-42-33-60-47-8-4-18-61-70(42)47)51(73)62-40-14-12-39(44(32-40)55(56,57)58)34-66-20-22-67(23-21-66)49(72)9-2-5-41-35-68(65-64-41)24-26-78-28-30-79-29-27-77-25-19-59-45-7-3-6-43-50(45)54(76)69(53(43)75)46-16-17-48(71)63-52(46)74/h3-4,6-8,10-12,14,18,31-33,35,46,59H,2,5,9,16-17,19-30,34H2,1H3,(H,62,73)(H,63,71,74)","SVYYVGZMWJYFIE-UHFFFAOYSA-N"
"1620","","BCR-ABL E255K","CRBN","","P19P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.5","Inhibit viability of K562 cells","19","P19P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1087.13","1086.43235606","3.55","79","9","17","3","22","236.82","C55H57F3N12O9","InChI=1S/C55H57F3N12O9/c1-36-10-11-38(31-37(36)13-15-42-33-60-47-8-4-18-61-70(42)47)51(73)62-40-14-12-39(44(32-40)55(56,57)58)34-66-20-22-67(23-21-66)49(72)9-2-5-41-35-68(65-64-41)24-26-78-28-30-79-29-27-77-25-19-59-45-7-3-6-43-50(45)54(76)69(53(43)75)46-16-17-48(71)63-52(46)74/h3-4,6-8,10-12,14,18,31-33,35,46,59H,2,5,9,16-17,19-30,34H2,1H3,(H,62,73)(H,63,71,74)","SVYYVGZMWJYFIE-UHFFFAOYSA-N"
"1620","","BCR-ABL H396R","CRBN","","P19P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.5","Inhibit viability of K562 cells","19","P19P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1087.13","1086.43235606","3.55","79","9","17","3","22","236.82","C55H57F3N12O9","InChI=1S/C55H57F3N12O9/c1-36-10-11-38(31-37(36)13-15-42-33-60-47-8-4-18-61-70(42)47)51(73)62-40-14-12-39(44(32-40)55(56,57)58)34-66-20-22-67(23-21-66)49(72)9-2-5-41-35-68(65-64-41)24-26-78-28-30-79-29-27-77-25-19-59-45-7-3-6-43-50(45)54(76)69(53(43)75)46-16-17-48(71)63-52(46)74/h3-4,6-8,10-12,14,18,31-33,35,46,59H,2,5,9,16-17,19-30,34H2,1H3,(H,62,73)(H,63,71,74)","SVYYVGZMWJYFIE-UHFFFAOYSA-N"
"1620","","BCR-ABL T315I","CRBN","","P19P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","","","","","","13.1","IC50 was tested on KinaseProfiler by Eurofins","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28.5","Inhibit viability of BaF3 BCR-ABL(T315I) cells","19","P19P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1087.13","1086.43235606","3.55","79","9","17","3","22","236.82","C55H57F3N12O9","InChI=1S/C55H57F3N12O9/c1-36-10-11-38(31-37(36)13-15-42-33-60-47-8-4-18-61-70(42)47)51(73)62-40-14-12-39(44(32-40)55(56,57)58)34-66-20-22-67(23-21-66)49(72)9-2-5-41-35-68(65-64-41)24-26-78-28-30-79-29-27-77-25-19-59-45-7-3-6-43-50(45)54(76)69(53(43)75)46-16-17-48(71)63-52(46)74/h3-4,6-8,10-12,14,18,31-33,35,46,59H,2,5,9,16-17,19-30,34H2,1H3,(H,62,73)(H,63,71,74)","SVYYVGZMWJYFIE-UHFFFAOYSA-N"
"1620","","BCR-ABL V468F","CRBN","","P19P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.5","Inhibit viability of K562 cells","19","P19P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1087.13","1086.43235606","3.55","79","9","17","3","22","236.82","C55H57F3N12O9","InChI=1S/C55H57F3N12O9/c1-36-10-11-38(31-37(36)13-15-42-33-60-47-8-4-18-61-70(42)47)51(73)62-40-14-12-39(44(32-40)55(56,57)58)34-66-20-22-67(23-21-66)49(72)9-2-5-41-35-68(65-64-41)24-26-78-28-30-79-29-27-77-25-19-59-45-7-3-6-43-50(45)54(76)69(53(43)75)46-16-17-48(71)63-52(46)74/h3-4,6-8,10-12,14,18,31-33,35,46,59H,2,5,9,16-17,19-30,34H2,1H3,(H,62,73)(H,63,71,74)","SVYYVGZMWJYFIE-UHFFFAOYSA-N"
"1621","","BCR-ABL","CRBN","","P22P","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(C(=O)CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2C=CC=NN12","70","","Degradation of BCR-ABL in K562 cells after 32 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20","P22P","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1131.183","1130.45857081","3.4","82","9","18","3","25","246.05","C57H61F3N12O10","InChI=1S/C57H61F3N12O10/c1-38-10-11-40(33-39(38)13-15-44-35-62-49-8-4-18-63-72(44)49)53(75)64-42-14-12-41(46(34-42)57(58,59)60)36-68-20-22-69(23-21-68)51(74)9-2-5-43-37-70(67-66-43)24-26-80-28-30-82-32-31-81-29-27-79-25-19-61-47-7-3-6-45-52(47)56(78)71(55(45)77)48-16-17-50(73)65-54(48)76/h3-4,6-8,10-12,14,18,33-35,37,48,61H,2,5,9,16-17,19-32,36H2,1H3,(H,64,75)(H,65,73,76)","OCHJOGLRDDWDLC-UHFFFAOYSA-N"
"1622","","BCR-ABL T315I","CRBN","","P22D1","CC1=CC=CC(/C=C/C2=CN=C(NC3=CC(N4CCN(C(=O)CCCC5=CN(CCOCCOCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)=NC(C)=N3)S2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","61000","Inhibit viability of BaF3 BCR-ABL(T315I) cells","50","P22D1","","","","","","","","","","","10.1021/acs.jmedchem.0c00967","1005.172","1004.4326925","4.07","72","8","19","3","26","237.46","C50H60N12O9S","InChI=1S/C50H60N12O9S/c1-34-6-3-7-36(30-34)12-13-38-32-52-50(72-38)55-42-31-43(54-35(2)53-42)59-17-19-60(20-18-59)45(64)11-4-8-37-33-61(58-57-37)21-23-69-25-27-71-29-28-70-26-24-68-22-16-51-40-10-5-9-39-46(40)49(67)62(48(39)66)41-14-15-44(63)56-47(41)65/h3,5-7,9-10,12-13,30-33,41,51H,4,8,11,14-29H2,1-2H3,(H,56,63,65)(H,52,53,54,55)/b13-12+","PSDDLUXQUHQEQH-OUKQBFOZSA-N"
"1623","","BCR-ABL","RNF114","","BT1","COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](C4=C(C5=CC=C(C(=O)NCCOCCOCCOCCN6CCN(C7=CC(NC8=NC=C(C(=O)NC9=C(C)C=CC=C9Cl)S8)=NC(C)=N7)CC6)C=C5)OC=C4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00348","1187.814","1186.46006839","6.71","84","11","19","3","22","235.11","C62H71ClN8O12S","InChI=1S/C62H71ClN8O12S/c1-35-9-8-10-42(63)51(35)69-57(75)44-34-65-59(84-44)68-47-33-48(67-37(3)66-47)71-21-19-70(20-22-71)23-26-79-28-30-80-29-27-78-25-18-64-56(74)39-13-11-38(12-14-39)52-40(16-24-81-52)41-31-43-50(36(41)2)62(6)45(32-49(73)77-7)61(5)46(72)15-17-60(4)54(61)53(55(62)82-43)83-58(60)76/h8-17,24,33-34,41,43,45,53-55H,18-23,25-32H2,1-7H3,(H,64,74)(H,69,75)(H,65,66,67,68)/t41-,43-,45-,53-,54+,55-,60-,61+,62-/m1/s1","WAFYDELZGOGNCH-JKSYLMTJSA-N"
"1624","","BCR-ABL","RNF114","","BT2","COC(=O)C[C@H]1[C@]2(C)C3=C(C)[C@H](C4=C(C5=CC=C(C(=O)NCCCN6CCN(C7=CC(NC8=NC=C(C(=O)NC9=C(C)C=CC=C9Cl)S8)=NC(C)=N7)CC6)C=C5)OC=C4)C[C@H]3O[C@@H]2[C@@H]2OC(=O)[C@]3(C)C=CC(=O)[C@@]1(C)[C@@H]23","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00348","1069.682","1068.39707421","7.51","76","11","16","3","14","207.42","C57H61ClN8O9S","InChI=1S/C57H61ClN8O9S/c1-30-10-8-11-37(58)46(30)64-52(70)39-29-60-54(76-39)63-42-28-43(62-32(3)61-42)66-23-21-65(22-24-66)20-9-19-59-51(69)34-14-12-33(13-15-34)47-35(17-25-73-47)36-26-38-45(31(36)2)57(6)40(27-44(68)72-7)56(5)41(67)16-18-55(4)49(56)48(50(57)74-38)75-53(55)71/h8,10-18,25,28-29,36,38,40,48-50H,9,19-24,26-27H2,1-7H3,(H,59,69)(H,64,70)(H,60,61,62,63)/t36-,38-,40-,48-,49+,50-,55-,56+,57-/m1/s1","XUZXLRFVXQYIBM-XXVFOTPMSA-N"
"1625","Q16539","p38alpha","CRBN","","NR-1a","CC1=CC=C(C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","790.618","789.160966968","5.4","53","6","9","3","12","155.91","C38H34BrF2N5O7","InChI=1S/C38H34BrF2N5O7/c1-20-8-9-22(17-29(20)45-21(2)16-30(33(39)38(45)52)53-19-23-10-11-24(40)18-26(23)41)34(48)43-15-4-3-14-42-27-7-5-6-25-32(27)37(51)46(36(25)50)28-12-13-31(47)44-35(28)49/h5-11,16-18,28,42H,3-4,12-15,19H2,1-2H3,(H,43,48)(H,44,47,49)","LHHPTQQCNHZVCC-UHFFFAOYSA-N"
"1626","Q16539","p38alpha","CRBN","","NR-2a","CC1=CC=C(C(=O)NCCCCNC(=O)C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","818.628","817.155881588","4.14","55","6","9","3","12","172.98","C39H34BrF2N5O8","InChI=1S/C39H34BrF2N5O8/c1-20-5-6-23(17-30(20)46-21(2)15-31(33(40)39(46)54)55-19-24-7-9-25(41)18-28(24)42)35(50)44-14-4-3-13-43-34(49)22-8-10-26-27(16-22)38(53)47(37(26)52)29-11-12-32(48)45-36(29)51/h5-10,15-18,29H,3-4,11-14,19H2,1-2H3,(H,43,49)(H,44,50)(H,45,48,51)","FRACMJZWOFXASS-UHFFFAOYSA-N"
"1627","Q16539","p38alpha","CRBN","","NR-1b","CC1=CC=C(C(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","850.67","849.182096336","4.39","57","6","11","3","16","174.37","C40H38BrF2N5O9","InChI=1S/C40H38BrF2N5O9/c1-22-6-7-24(19-31(22)47-23(2)18-32(35(41)40(47)54)57-21-25-8-9-26(42)20-28(25)43)36(50)45-13-15-56-17-16-55-14-12-44-29-5-3-4-27-34(29)39(53)48(38(27)52)30-10-11-33(49)46-37(30)51/h3-9,18-20,30,44H,10-17,21H2,1-2H3,(H,45,50)(H,46,49,51)","LPYXIUXMVADWJU-UHFFFAOYSA-N"
"1628","Q16539","p38alpha","CRBN","","NR-2b","CC1=CC=C(C(=O)NCCOCCOCCNC(=O)C2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","878.68","877.177010956","3.13","59","6","11","3","16","191.44","C41H38BrF2N5O10","InChI=1S/C41H38BrF2N5O10/c1-22-3-4-25(19-32(22)48-23(2)17-33(35(42)41(48)56)59-21-26-5-7-27(43)20-30(26)44)37(52)46-12-14-58-16-15-57-13-11-45-36(51)24-6-8-28-29(18-24)40(55)49(39(28)54)31-9-10-34(50)47-38(31)53/h3-8,17-20,31H,9-16,21H2,1-2H3,(H,45,51)(H,46,52)(H,47,50,53)","OIZOWFZTQYNJAJ-UHFFFAOYSA-N"
"1629","Q16539","p38alpha","CRBN","","NR-1c","CC1=CC=C(C(=O)NCCOCCOCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","1026.882","1025.28695533","3.8","69","6","15","3","28","211.29","C48H54BrF2N5O13","InChI=1S/C48H54BrF2N5O13/c1-30-6-7-32(27-39(30)55-31(2)26-40(43(49)48(55)62)69-29-33-8-9-34(50)28-36(33)51)44(58)53-13-15-64-17-19-66-21-23-68-25-24-67-22-20-65-18-16-63-14-12-52-37-5-3-4-35-42(37)47(61)56(46(35)60)38-10-11-41(57)54-45(38)59/h3-9,26-28,38,52H,10-25,29H2,1-2H3,(H,53,58)(H,54,57,59)","RHYZBIMBCHCVPO-UHFFFAOYSA-N"
"1630","Q16539","p38alpha","CRBN","","NR-3a","CC1=CC=C(C(=O)NCCCCC2=CN(CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","1017.882","1016.28795837","4.65","69","7","15","3","24","214.31","C48H51BrF2N8O10","InChI=1S/C48H51BrF2N8O10/c1-29-9-10-31(25-39(29)58-30(2)24-40(43(49)48(58)65)69-28-32-11-12-33(50)26-36(32)51)44(61)53-15-4-3-6-34-27-57(56-55-34)17-19-67-21-23-68-22-20-66-18-16-52-37-8-5-7-35-42(37)47(64)59(46(35)63)38-13-14-41(60)54-45(38)62/h5,7-12,24-27,38,52H,3-4,6,13-23,28H2,1-2H3,(H,53,61)(H,54,60,62)","FOKIZZKHPYXPGZ-UHFFFAOYSA-N"
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"1644","Q16539","p38alpha","CRBN","","NR-7g","CC1=CC=C(C(=O)NCCCCC2=CN(CCCC(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","984.856","983.277728036","5.05","67","7","13","4","20","215.72","C47H48BrF2N9O8","InChI=1S/C47H48BrF2N9O8/c1-27-12-13-29(23-37(27)58-28(2)22-38(42(48)47(58)66)67-26-30-14-15-31(49)24-34(30)50)43(62)53-18-4-3-8-32-25-57(56-55-32)21-6-11-39(60)52-20-7-19-51-35-10-5-9-33-41(35)46(65)59(45(33)64)36-16-17-40(61)54-44(36)63/h5,9-10,12-15,22-25,36,51H,3-4,6-8,11,16-21,26H2,1-2H3,(H,52,60)(H,53,62)(H,54,61,63)","FAYFXFOCNDQPDJ-UHFFFAOYSA-N"
"1645","Q15759","p38beta","CRBN","","NR-7h","CC1=CC=C(C(=O)NCCCCC2=CN(CCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","48.47/48.9","","Degradation of p38beta in T47D/MB-MDA-231 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","998.883","997.2933781","5.41","68","7","13","4","21","215.72","C48H50BrF2N9O8","InChI=1S/C48H50BrF2N9O8/c1-28-13-14-30(24-38(28)59-29(2)23-39(43(49)48(59)67)68-27-31-15-16-32(50)25-35(31)51)44(63)54-21-4-3-9-33-26-58(57-56-33)22-8-12-40(61)53-20-6-5-19-52-36-11-7-10-34-42(36)47(66)60(46(34)65)37-17-18-41(62)55-45(37)64/h7,10-11,13-16,23-26,37,52H,3-6,8-9,12,17-22,27H2,1-2H3,(H,53,61)(H,54,63)(H,55,62,64)","BEMLUUUHZPFCBS-UHFFFAOYSA-N"
"1645","Q16539","p38alpha","CRBN","","NR-7h","CC1=CC=C(C(=O)NCCCCC2=CN(CCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","24/27.2","","Degradation of p38alpha in T47D/MB-MDA-231 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","998.883","997.2933781","5.41","68","7","13","4","21","215.72","C48H50BrF2N9O8","InChI=1S/C48H50BrF2N9O8/c1-28-13-14-30(24-38(28)59-29(2)23-39(43(49)48(59)67)68-27-31-15-16-32(50)25-35(31)51)44(63)54-21-4-3-9-33-26-58(57-56-33)22-8-12-40(61)53-20-6-5-19-52-36-11-7-10-34-42(36)47(66)60(46(34)65)37-17-18-41(62)55-45(37)64/h7,10-11,13-16,23-26,37,52H,3-6,8-9,12,17-22,27H2,1-2H3,(H,53,61)(H,54,63)(H,55,62,64)","BEMLUUUHZPFCBS-UHFFFAOYSA-N"
"1646","Q16539","p38alpha","CRBN","","NR-7i","CC1=CC=C(C(=O)NCCCCC2=CN(CC[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","1114.015","1112.35670663","6.24","76","7","15","5","22","254.05","C53H59BrF2N10O10","InChI=1S/C53H59BrF2N10O10/c1-30-14-15-32(26-41(30)65-31(2)25-42(45(54)51(65)73)75-29-33-16-17-34(55)27-37(33)56)46(68)58-22-7-6-11-35-28-64(63-62-35)24-20-39(60-52(74)76-53(3,4)5)47(69)59-23-9-8-21-57-38-13-10-12-36-44(38)50(72)66(49(36)71)40-18-19-43(67)61-48(40)70/h10,12-17,25-28,39-40,57H,6-9,11,18-24,29H2,1-5H3,(H,58,68)(H,59,69)(H,60,74)(H,61,67,70)/t39-,40?/m0/s1","PVYVOBKFADDYJK-KLBOFATRSA-N"
"1647","Q16539","p38alpha","CRBN","","NR-7j","CC1=CC=C(C(=O)NCCCCC2=CN(CC[C@H]([NH3+])C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)C=C1N1C(C)=CC(OCC2=CC=C(F)C=C2F)=C(Br)C1=O.[Cl-]","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112451","1050.359","1048.28095484","5.4","70","7","13","5","21","243.36","C48H52BrClF2N10O8","InChI=1S/C48H51BrF2N10O8.ClH/c1-27-11-12-29(23-38(27)60-28(2)22-39(42(49)48(60)68)69-26-30-13-14-31(50)24-34(30)51)43(63)54-19-4-3-8-32-25-59(58-57-32)21-17-35(52)44(64)55-20-6-5-18-53-36-10-7-9-33-41(36)47(67)61(46(33)66)37-15-16-40(62)56-45(37)65;/h7,9-14,22-25,35,37,53H,3-6,8,15-21,26,52H2,1-2H3,(H,54,63)(H,55,64)(H,56,62,65);1H/t35-,37?;/m0./s1","QSKODCKADWQMNF-IEQDCBNCSA-N"
"1648","","BCR-ABL","VHL","","GMB-805","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCNC3=NC=C(C(=O)NC4=CC=C(OC(F)(F)Cl)C=C4)C=C3C3=CC=N[NH]3)C(C)(C)C)C=C2)SC=N1","30","","Degradation of BCR-ABL in K562 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","169","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1039/d0cc02201b","894.402","893.289749932","5.35","62","6","12","6","17","212.79","C42H46ClF2N9O7S","InChI=1S/C42H46ClF2N9O7S/c1-24-35(62-23-49-24)26-7-5-25(6-8-26)19-48-39(58)33-18-29(55)21-54(33)40(59)36(41(2,3)4)52-34(56)22-60-16-15-46-37-31(32-13-14-50-53-32)17-27(20-47-37)38(57)51-28-9-11-30(12-10-28)61-42(43,44)45/h5-14,17,20,23,29,33,36,55H,15-16,18-19,21-22H2,1-4H3,(H,46,47)(H,48,58)(H,50,53)(H,51,57)(H,52,56)/t29-,33+,36-/m1/s1","ZZAMCOWPQNSLBF-CPIPLPSASA-N"
"1649","Q07817","BCL-xL","VHL","6ZHC","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCC#CC3=CC=C(OCCCC4=C(C(=O)O)N=C(N5CCC6=CC=CC(C(=O)NC7=NC8=CC=CC=C8S7)=C6C5)S4)C=C3)C(C)(C)C)C=C2)SC=N1","4.8","76","Degradation of BCL-xL in THP-1 cells after 24 h treatment","","","0.6","IC50 was tested by HTRF assay","","","","","","","","","","","","","","","190","SPR","","","","","","","","","","","","","","","290","Titrations of PROTAC over an immobilised VCB surface in the presence of BCL-xL (SPR)","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.0c00266","1329.631","1328.49561224","8.07","93","9","20","5","34","271.66","C68H80N8O14S3","InChI=1S/C68H80N8O14S3/c1-45-60(91-44-70-45)49-20-16-47(17-21-49)41-69-63(80)55-40-50(77)42-76(55)64(81)61(68(2,3)4)72-58(78)25-29-85-31-33-87-35-37-89-39-38-88-36-34-86-32-30-84-27-8-10-46-18-22-51(23-19-46)90-28-9-15-57-59(65(82)83)73-67(93-57)75-26-24-48-11-7-12-52(53(48)43-75)62(79)74-66-71-54-13-5-6-14-56(54)92-66/h5-7,11-14,16-23,44,50,55,61,77H,9,15,24-43H2,1-4H3,(H,69,80)(H,72,78)(H,82,83)(H,71,74,79)/t50-,55+,61-/m1/s1","LOJJAKUNUJJOKC-MXEISZGISA-N"
"1650","Q06187","BTK","CRBN","","","NC(=O)C1=C(N)N([C@@H]2CCCN(C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)N=C1C1=CC=C(OC2=CC=C(F)C=C2F)C=C1","9.6","","Degradation of BTK in Ramos cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1073/pnas.1803662115","1109.147","1108.45648447","2.32","79","7","20","4","34","295.12","C53H66F2N8O16","InChI=1S/C53H66F2N8O16/c54-36-8-12-43(40(55)33-36)79-38-9-6-35(7-10-38)47-46(49(57)65)48(56)63(60-47)37-3-2-15-61(34-37)53(69)78-32-31-77-30-29-76-28-27-75-26-25-74-24-23-73-22-21-72-20-19-71-18-17-70-16-14-58-41-5-1-4-39-45(41)52(68)62(51(39)67)42-11-13-44(64)59-50(42)66/h1,4-10,12,33,37,42,58H,2-3,11,13-32,34,56H2,(H2,57,65)(H,59,64,66)/t37-,42?/m1/s1","YOXZTCCVXQIAMP-SZUYGLCUSA-N"
"1651","P25440","BRD2","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","37","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","116","ITC","","","-9.46","-4.07","-5.39","ITC","","","","","","","","","","","","","","","","","","","","","","","575/676","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1651","P25440","BRD2","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","104","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1651","Q15059","BRD3","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","104","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1651","O60885","BRD4","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","104","SPR","","","","","","","","","","","","","","","465","Kd between VHL and the complex of protac and BRD4 BD2 was tested by SPR","","","","","","","3000000","1","0.8","SPR between VHL and BRD4 BD2:PROTAC","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1651","Q15059","BRD3","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","158","74","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","116","ITC","","","-9.46","-4.07","-5.39","ITC","","","","","","","","","","","","","","","","","","","","","","","575/676","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1651","O60885","BRD4","VHL","","MZP-61","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","126/200","94/78","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","3","Kd of BRD4 BD2 was tested by ITC","","","-11.7","-10","-1.71","ITC in BRD4 BD2","","","","","","","","","116","ITC","","","-9.46","-4.07","-5.39","ITC","","","","","","","","","781","Kd between VHL and the complex of protac and BRD4 BD2 was tested by ITC","","","-8.33","-7.02","-1.31","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","575/676","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","992.64","991.406910624","6.71","70","7","11","5","18","191.53","C53H62ClN7O8S","InChI=1S/C53H62ClN7O8S/c1-32-25-44(58-41-18-16-40(54)17-19-41)43-26-39(15-20-45(43)61(32)34(3)62)36-11-13-38(14-12-36)50(65)55-21-22-68-23-24-69-30-47(64)59-49(53(4,5)6)52(67)60-29-42(63)27-46(60)51(66)56-28-35-7-9-37(10-8-35)48-33(2)57-31-70-48/h7-20,26,31-32,42,44,46,49,58,63H,21-25,27-30H2,1-6H3,(H,55,65)(H,56,66)(H,59,64)/t32-,42+,44+,46-,49+/m0/s1","AIFXAXRMMBWMAG-OVLUFEKXSA-N"
"1652","P25440","BRD2","VHL","","MZP-54","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","43","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","105","ITC","","","-9.52","-6.18","-3.34","ITC","","","","","","","","","","","","","","","","","","","","","","","49/269","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1036.693","1035.43312537","6.56","73","7","12","5","21","200.76","C55H66ClN7O9S","InChI=1S/C55H66ClN7O9S/c1-34-27-46(60-43-18-16-42(56)17-19-43)45-28-41(15-20-47(45)63(34)36(3)64)38-11-13-40(14-12-38)52(67)57-21-22-70-23-24-71-25-26-72-32-49(66)61-51(55(4,5)6)54(69)62-31-44(65)29-48(62)53(68)58-30-37-7-9-39(10-8-37)50-35(2)59-33-73-50/h7-20,28,33-34,44,46,48,51,60,65H,21-27,29-32H2,1-6H3,(H,57,67)(H,58,68)(H,61,66)/t34-,44+,46+,48-,51+/m0/s1","FYSWLIFIYIVHPI-DDWISSAJSA-N"
"1652","Q15059","BRD3","VHL","","MZP-54","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","50","91","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","105","ITC","","","-9.52","-6.18","-3.34","ITC","","","","","","","","","","","","","","","","","","","","","","","49/269","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1036.693","1035.43312537","6.56","73","7","12","5","21","200.76","C55H66ClN7O9S","InChI=1S/C55H66ClN7O9S/c1-34-27-46(60-43-18-16-42(56)17-19-43)45-28-41(15-20-47(45)63(34)36(3)64)38-11-13-40(14-12-38)52(67)57-21-22-70-23-24-71-25-26-72-32-49(66)61-51(55(4,5)6)54(69)62-31-44(65)29-48(62)53(68)58-30-37-7-9-39(10-8-37)50-35(2)59-33-73-50/h7-20,28,33-34,44,46,48,51,60,65H,21-27,29-32H2,1-6H3,(H,57,67)(H,58,68)(H,61,66)/t34-,44+,46+,48-,51+/m0/s1","FYSWLIFIYIVHPI-DDWISSAJSA-N"
"1652","O60885","BRD4","VHL","","MZP-54","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","8/25","98/95","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","4","Kd of BRD4 BD2 was tested by ITC","","","-11.5","-9.74","-1.73","ITC in BRD4 BD2","","","","","","","","","105","ITC","","","-9.52","-6.18","-3.34","ITC","","","","","","","","","228","Kd between VHL and the complex of protac and BRD4 BD2 was tested by ITC","","","-9.06","-6.9","-2.16","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","49/269","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1036.693","1035.43312537","6.56","73","7","12","5","21","200.76","C55H66ClN7O9S","InChI=1S/C55H66ClN7O9S/c1-34-27-46(60-43-18-16-42(56)17-19-43)45-28-41(15-20-47(45)63(34)36(3)64)38-11-13-40(14-12-38)52(67)57-21-22-70-23-24-71-25-26-72-32-49(66)61-51(55(4,5)6)54(69)62-31-44(65)29-48(62)53(68)58-30-37-7-9-39(10-8-37)50-35(2)59-33-73-50/h7-20,28,33-34,44,46,48,51,60,65H,21-27,29-32H2,1-6H3,(H,57,67)(H,58,68)(H,61,66)/t34-,44+,46+,48-,51+/m0/s1","FYSWLIFIYIVHPI-DDWISSAJSA-N"
"1653","P25440","BRD2","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","26","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","45/5","Kd of BRD2 BD1/2 was tested by ITC","","","-10/-11.3","-11.9/-10.1","1.86/-1.19","ITC in BRD2 BD1/2","","","","","","","","","109","ITC","","","-9.5","-8.01","-1.5","ITC","","","","","","","","","328/384","Kd between VHL and the complex of protac and BRD2 BD1/2 was tested by ITC","","","-8.95/-8.8","-4.76/-7.77","-4.19/-1.02","ITC between VHL and BRD2 BD1/2:PROTAC","","","","","","","83/427","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1653","P25440","BRD2","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","69","SPR","","","","","","","270000","0.015","48","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1653","Q15059","BRD3","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","69","SPR","","","","","","","270000","0.015","48","SPR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1653","O60885","BRD4","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","69","SPR","","","","","","","270000","0.015","48","SPR","","","","","185","Kd between VHL and the complex of protac and BRD4 BD2 was tested by SPR","","","","","","","2700000","0.47","1.5","SPR between VHL and BRD4 BD2:PROTAC","","","","","","","","","","","","","","","","","10.1021/acschembio.9b00092","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1653","Q15059","BRD3","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","20","92","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","39/11","Kd of BRD3 BD1/2 was tested by ITC","","","-10.1/-10.9","-13.3/-13.9","3.2/3","ITC in BRD3 BD1/2","","","","","","","","","109","ITC","","","-9.5","-8.01","-1.5","ITC","","","","","","","","","152/434","Kd between VHL and the complex of protac and BRD3 BD1/2 was tested by ITC","","","-9.31/-8.71","-4.13/-7.33","-5.18/-1.37","ITC between VHL and BRD3 BD1/2:PROTAC","","","","","","","83/427","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1653","O60885","BRD4","VHL","","MZP-55","CC(=O)N1C2=CC=C(C3=CC=C(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)C=C3)C=C2[C@H](NC2=CC=C(Cl)C=C2)C[C@@H]1C","8/32","95/93","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","39/8","Kd of BRD4 BD1/2 was tested by ITC","","","-10.3/-11.1","-11.9/-10.8","1.6/-0.33","ITC in BRD4 BD1/2","","","","","","","","","109","ITC","","","-9.5","-8.01","-1.5","ITC","","","","","","","","","221/183","Kd between VHL and the complex of protac and BRD4 BD1/2 was tested by ITC","","","-9.11/-9.2","-2.47/-7.58","-6.63/-1.62","ITC between VHL and BRD4 BD1/2:PROTAC","","","","","","","83/427","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","1080.746","1079.45934012","6.41","76","7","13","5","24","209.99","C57H70ClN7O10S","InChI=1S/C57H70ClN7O10S/c1-36-29-48(62-45-18-16-44(58)17-19-45)47-30-43(15-20-49(47)65(36)38(3)66)40-11-13-42(14-12-40)54(69)59-21-22-72-23-24-73-25-26-74-27-28-75-34-51(68)63-53(57(4,5)6)56(71)64-33-46(67)31-50(64)55(70)60-32-39-7-9-41(10-8-39)52-37(2)61-35-76-52/h7-20,30,35-36,46,48,50,53,62,67H,21-29,31-34H2,1-6H3,(H,59,69)(H,60,70)(H,63,68)/t36-,46+,48+,50-,53+/m0/s1","UHWNJFZTYJNBAN-HYXXSBGTSA-N"
"1654","P25440","BRD2","VHL","","MZ4","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","631","93","Degradation of BRD2 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","147","ITC","","","-9.34","-5.72","-3.61","ITC","","","","","","","","","","","","","","","","","","","","","","","178/1445","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","958.608","957.343264812","5.11","66","7","14","4","17","202.26","C47H56ClN9O7S2","InChI=1S/C47H56ClN9O7S2/c1-26-28(3)66-46-39(26)40(31-12-14-33(48)15-13-31)52-35(43-55-54-29(4)57(43)46)21-37(59)49-16-17-63-18-19-64-24-38(60)53-42(47(5,6)7)45(62)56-23-34(58)20-36(56)44(61)50-22-30-8-10-32(11-9-30)41-27(2)51-25-65-41/h8-15,25,34-36,42,58H,16-24H2,1-7H3,(H,49,59)(H,50,61)(H,53,60)/t34-,35+,36+,42-/m1/s1","UAQDCZFGBBSHLT-PBSGCNNPSA-N"
"1654","Q15059","BRD3","VHL","","MZ4","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","316","97","Degradation of BRD3 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","147","ITC","","","-9.34","-5.72","-3.61","ITC","","","","","","","","","","","","","","","","","","","","","","","178/1445","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","958.608","957.343264812","5.11","66","7","14","4","17","202.26","C47H56ClN9O7S2","InChI=1S/C47H56ClN9O7S2/c1-26-28(3)66-46-39(26)40(31-12-14-33(48)15-13-31)52-35(43-55-54-29(4)57(43)46)21-37(59)49-16-17-63-18-19-64-24-38(60)53-42(47(5,6)7)45(62)56-23-34(58)20-36(56)44(61)50-22-30-8-10-32(11-9-30)41-27(2)51-25-65-41/h8-15,25,34-36,42,58H,16-24H2,1-7H3,(H,49,59)(H,50,61)(H,53,60)/t34-,35+,36+,42-/m1/s1","UAQDCZFGBBSHLT-PBSGCNNPSA-N"
"1654","O60885","BRD4","VHL","","MZ4","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","100/100","96/97","Degradation of BRD4 short/long in HeLa cells after 24 h treatment","","","","","","","17","ITC in BRD4 BD2","","","-10.6","-11.2","-0.65","ITC in BRD4 BD2","","","","","","","","","147","ITC","","","-9.34","-5.72","-3.61","ITC","","","","","","","","","26","Kd between VHL and MZ4-BRD4 BD2 was tested by ITC","","","-10.4","-5.36","-5.05","ITC between VHL and BRD4 BD2:PROTAC","","","","","","","178/1445","Inhibit proliferation of MV4;11/HL60 cells","","","","","","","","","","","","","10.1021/acs.jmedchem.6b01912","958.608","957.343264812","5.11","66","7","14","4","17","202.26","C47H56ClN9O7S2","InChI=1S/C47H56ClN9O7S2/c1-26-28(3)66-46-39(26)40(31-12-14-33(48)15-13-31)52-35(43-55-54-29(4)57(43)46)21-37(59)49-16-17-63-18-19-64-24-38(60)53-42(47(5,6)7)45(62)56-23-34(58)20-36(56)44(61)50-22-30-8-10-32(11-9-30)41-27(2)51-25-65-41/h8-15,25,34-36,42,58H,16-24H2,1-7H3,(H,49,59)(H,50,61)(H,53,60)/t34-,35+,36+,42-/m1/s1","UAQDCZFGBBSHLT-PBSGCNNPSA-N"
"1655","Q05397","FAK","CRBN","","BI-3663","COC1=CC(C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","158/50/13","79/93/93","Degradation of Fak in HLE/HuH-7/SNU-423 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">25119/>25119/19953","Inhibit proliferation of HLE/HuH-7/SNU-423 cells","","","","","","","","","","","1","Compounds were administered at 10000 nM and incubated for 2 h","17","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acs.jmedchem.8b01826","917.851","917.284354444","2.93","66","7","15","4","20","242.78","C44H42F3N7O12","InChI=1S/C44H42F3N7O12/c1-62-33-22-25(8-10-28(33)51-43-49-23-27(44(45,46)47)40(53-43)66-32-7-2-4-24-9-12-31(55)36(24)32)38(58)48-15-17-64-19-21-65-20-18-63-16-14-35(57)50-29-6-3-5-26-37(29)42(61)54(41(26)60)30-11-13-34(56)52-39(30)59/h2-8,10,22-23,30H,9,11-21H2,1H3,(H,48,58)(H,50,57)(H,49,51,53)(H,52,56,59)","ADTXLFJKQHYGPM-UHFFFAOYSA-N"
"1655","Q05397","FAK","CRBN","","BI-3663","COC1=CC(C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","251/32/32","50/89/89","Degradation of Fak in HUH-1/HepG2/SK-Hep-1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25119/>25119/1585","Inhibit proliferation of HUH-1/HepG2/SK-Hep-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","917.851","917.284354444","2.93","66","7","15","4","20","242.78","C44H42F3N7O12","InChI=1S/C44H42F3N7O12/c1-62-33-22-25(8-10-28(33)51-43-49-23-27(44(45,46)47)40(53-43)66-32-7-2-4-24-9-12-31(55)36(24)32)38(58)48-15-17-64-19-21-65-20-18-63-16-14-35(57)50-29-6-3-5-26-37(29)42(61)54(41(26)60)30-11-13-34(56)52-39(30)59/h2-8,10,22-23,30H,9,11-21H2,1H3,(H,48,58)(H,50,57)(H,49,51,53)(H,52,56,59)","ADTXLFJKQHYGPM-UHFFFAOYSA-N"
"1655","Q05397","FAK","CRBN","","BI-3663","COC1=CC(C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","27/13/25","95/96/90","Degradation of Fak in A549/Hep3B2.1-7/SNU-387 cells after 18 h treatment","","","18","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">25119/25119","Inhibit proliferation of SNU-387/Hep3B2.1-7 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","917.851","917.284354444","2.93","66","7","15","4","20","242.78","C44H42F3N7O12","InChI=1S/C44H42F3N7O12/c1-62-33-22-25(8-10-28(33)51-43-49-23-27(44(45,46)47)40(53-43)66-32-7-2-4-24-9-12-31(55)36(24)32)38(58)48-15-17-64-19-21-65-20-18-63-16-14-35(57)50-29-6-3-5-26-37(29)42(61)54(41(26)60)30-11-13-34(56)52-39(30)59/h2-8,10,22-23,30H,9,11-21H2,1H3,(H,48,58)(H,50,57)(H,49,51,53)(H,52,56,59)","ADTXLFJKQHYGPM-UHFFFAOYSA-N"
"1655","Q05397","FAK","CRBN","","BI-3663","COC1=CC(C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","398/3/13","30/95/90","Degradation of Fak in HLF/SNU-398/HUCCT1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">25119/>25119/>25119","Inhibit proliferation of HLF/SNU-398/HUCCT1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","917.851","917.284354444","2.93","66","7","15","4","20","242.78","C44H42F3N7O12","InChI=1S/C44H42F3N7O12/c1-62-33-22-25(8-10-28(33)51-43-49-23-27(44(45,46)47)40(53-43)66-32-7-2-4-24-9-12-31(55)36(24)32)38(58)48-15-17-64-19-21-65-20-18-63-16-14-35(57)50-29-6-3-5-26-37(29)42(61)54(41(26)60)30-11-13-34(56)52-39(30)59/h2-8,10,22-23,30H,9,11-21H2,1H3,(H,48,58)(H,50,57)(H,49,51,53)(H,52,56,59)","ADTXLFJKQHYGPM-UHFFFAOYSA-N"
"1656","Q05397","FAK","VHL","","BI-0319","COC1=CC(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","243/631/32","80/59/98","Degradation of Fak in A549/Hep3B2.1-7/SNU-387 cells after 18 h treatment","","","19","Inhibition of Fak","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5012/6310","Inhibit proliferation of SNU-387/Hep3B2.1-7 cells","","","","","","","","","","","<1","Compounds were administered at 10000 nM and incubated for 2 h","11","Compounds were administered at 10000 nM and incubated for 2 h","10.1021/acs.jmedchem.8b01826","1061.15","1060.39761037","5.49","75","7","16","5","23","241.76","C52H59F3N8O11S","InChI=1S/C52H59F3N8O11S/c1-30-44(75-29-59-30)33-11-9-31(10-12-33)25-57-47(68)38-24-35(64)27-63(38)49(69)45(51(2,3)4)61-42(66)28-73-22-21-72-20-19-71-18-17-56-46(67)34-13-15-37(41(23-34)70-5)60-50-58-26-36(52(53,54)55)48(62-50)74-40-8-6-7-32-14-16-39(65)43(32)40/h6-13,15,23,26,29,35,38,45,64H,14,16-22,24-25,27-28H2,1-5H3,(H,56,67)(H,57,68)(H,61,66)(H,58,60,62)/t35-,38+,45-/m1/s1","UVVQLQQNGHYTOL-JIVXZRRKSA-N"
"1656","Q05397","FAK","VHL","","BI-0319","COC1=CC(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","25/100/79","85/79/87","Degradation of Fak in HLE/HuH-7/SNU-423 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10000/3981/6310","Inhibit proliferation of HLE/HuH-7/SNU-423 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","1061.15","1060.39761037","5.49","75","7","16","5","23","241.76","C52H59F3N8O11S","InChI=1S/C52H59F3N8O11S/c1-30-44(75-29-59-30)33-11-9-31(10-12-33)25-57-47(68)38-24-35(64)27-63(38)49(69)45(51(2,3)4)61-42(66)28-73-22-21-72-20-19-71-18-17-56-46(67)34-13-15-37(41(23-34)70-5)60-50-58-26-36(52(53,54)55)48(62-50)74-40-8-6-7-32-14-16-39(65)43(32)40/h6-13,15,23,26,29,35,38,45,64H,14,16-22,24-25,27-28H2,1-5H3,(H,56,67)(H,57,68)(H,61,66)(H,58,60,62)/t35-,38+,45-/m1/s1","UVVQLQQNGHYTOL-JIVXZRRKSA-N"
"1656","Q05397","FAK","VHL","","BI-0319","COC1=CC(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","40/10/126","66/99/86","Degradation of Fak in HLF/SNU-398/HUCCT1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">25119/7943/6310","Inhibit proliferation of HLF/SNU-398/HUCCT1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","1061.15","1060.39761037","5.49","75","7","16","5","23","241.76","C52H59F3N8O11S","InChI=1S/C52H59F3N8O11S/c1-30-44(75-29-59-30)33-11-9-31(10-12-33)25-57-47(68)38-24-35(64)27-63(38)49(69)45(51(2,3)4)61-42(66)28-73-22-21-72-20-19-71-18-17-56-46(67)34-13-15-37(41(23-34)70-5)60-50-58-26-36(52(53,54)55)48(62-50)74-40-8-6-7-32-14-16-39(65)43(32)40/h6-13,15,23,26,29,35,38,45,64H,14,16-22,24-25,27-28H2,1-5H3,(H,56,67)(H,57,68)(H,61,66)(H,58,60,62)/t35-,38+,45-/m1/s1","UVVQLQQNGHYTOL-JIVXZRRKSA-N"
"1656","Q05397","FAK","VHL","","BI-0319","COC1=CC(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1NC1=NC=C(C(F)(F)F)C(OC2=CC=CC3=C2C(=O)CC3)=N1","79/631/126","79/65/87","Degradation of Fak in HUH-1/HepG2/SK-Hep-1 cells after 18 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19953/>25119/7943","Inhibit proliferation of HUH-1/HepG2/SK-Hep-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.8b01826","1061.15","1060.39761037","5.49","75","7","16","5","23","241.76","C52H59F3N8O11S","InChI=1S/C52H59F3N8O11S/c1-30-44(75-29-59-30)33-11-9-31(10-12-33)25-57-47(68)38-24-35(64)27-63(38)49(69)45(51(2,3)4)61-42(66)28-73-22-21-72-20-19-71-18-17-56-46(67)34-13-15-37(41(23-34)70-5)60-50-58-26-36(52(53,54)55)48(62-50)74-40-8-6-7-32-14-16-39(65)43(32)40/h6-13,15,23,26,29,35,38,45,64H,14,16-22,24-25,27-28H2,1-5H3,(H,56,67)(H,57,68)(H,61,66)(H,58,60,62)/t35-,38+,45-/m1/s1","UVVQLQQNGHYTOL-JIVXZRRKSA-N"
"1657","P01116","KRAS G12C","VHL","","LC-1","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCC(=O)NCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","","30","Degradation of KRAS G12C in NCI-H2030 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/1300","Inhibit viability of NCI-H2030/NCI-H23 cells","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1233.91","1232.54079898","6.02","87","9","17","4","25","248.02","C63H78ClFN12O9S","InChI=1S/C63H78ClFN12O9S/c1-40(65)60(82)76-28-27-75(35-45(76)18-22-66)58-48-19-25-74(51-13-7-10-43-9-6-12-49(64)55(43)51)37-50(48)70-62(72-58)86-38-46-11-8-24-73(46)26-20-53(79)67-23-30-85-32-31-84-29-21-54(80)71-57(63(3,4)5)61(83)77-36-47(78)33-52(77)59(81)68-34-42-14-16-44(17-15-42)56-41(2)69-39-87-56/h6-7,9-10,12-17,39,45-47,52,57,78H,1,8,11,18-21,23-38H2,2-5H3,(H,67,79)(H,68,81)(H,71,80)/t45-,46-,47+,52-,57+/m0/s1","AQGODMPACFJSJH-DRLKIAAISA-N"
"1658","P01116","KRAS G12C","VHL","","LC-2","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","250/520","90/40","Degradation of KRAS G12C in NCI-H23/NCI-H358 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1132.805","1131.49312051","7.27","80","9","15","3","20","209.69","C59H71ClFN11O7S","InChI=1S/C59H71ClFN11O7S/c1-37(61)56(76)71-27-26-70(32-42(71)19-22-62)54-45-20-25-69(48-14-7-11-40-10-6-13-46(60)51(40)48)34-47(45)65-58(67-54)79-35-43-12-8-23-68(43)24-9-28-78-29-21-50(74)66-53(59(3,4)5)57(77)72-33-44(73)30-49(72)55(75)63-31-39-15-17-41(18-16-39)52-38(2)64-36-80-52/h6-7,10-11,13-18,36,42-44,49,53,73H,1,8-9,12,19-21,23-35H2,2-5H3,(H,63,75)(H,66,74)/t42-,43-,44+,49-,53+/m0/s1","ZCGQZLKPUVGCBQ-HLMPTVQRSA-N"
"1658","P01116","KRAS G12C","VHL","","LC-2","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","590/320/760","80/75/90","Degradation of KRAS G12C in NCI-H2030/MIA PaCa-2/SW1573 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3800/2900","Inhibit viability of NCI-H2030/NCI-H23 cells","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1132.805","1131.49312051","7.27","80","9","15","3","20","209.69","C59H71ClFN11O7S","InChI=1S/C59H71ClFN11O7S/c1-37(61)56(76)71-27-26-70(32-42(71)19-22-62)54-45-20-25-69(48-14-7-11-40-10-6-13-46(60)51(40)48)34-47(45)65-58(67-54)79-35-43-12-8-23-68(43)24-9-28-78-29-21-50(74)66-53(59(3,4)5)57(77)72-33-44(73)30-49(72)55(75)63-31-39-15-17-41(18-16-39)52-38(2)64-36-80-52/h6-7,10-11,13-18,36,42-44,49,53,73H,1,8-9,12,19-21,23-35H2,2-5H3,(H,63,75)(H,66,74)/t42-,43-,44+,49-,53+/m0/s1","ZCGQZLKPUVGCBQ-HLMPTVQRSA-N"
"1659","P01116","KRAS G12C","VHL","","LC-3","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCC(=O)NCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","640","85","Degradation of KRAS G12C in NCI-H2030 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1145.804","1144.48836948","6.31","81","9","15","4","19","229.56","C59H70ClFN12O7S","InChI=1S/C59H70ClFN12O7S/c1-36(61)56(78)72-28-27-71(31-41(72)18-22-62)54-44-20-25-70(47-13-7-10-39-9-6-12-45(60)51(39)47)33-46(44)66-58(68-54)80-34-42-11-8-24-69(42)26-21-49(75)63-23-19-50(76)67-53(59(3,4)5)57(79)73-32-43(74)29-48(73)55(77)64-30-38-14-16-40(17-15-38)52-37(2)65-35-81-52/h6-7,9-10,12-17,35,41-43,48,53,74H,1,8,11,18-21,23-34H2,2-5H3,(H,63,75)(H,64,77)(H,67,76)/t41-,42-,43+,48-,53+/m0/s1","QSJKPPVXARILLJ-GYUTUTRISA-N"
"1660","P01116","KRAS G12C","VHL","","LC-4","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","880","90","Degradation of KRAS G12C in SW1573 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1146.832","1145.50877058","7.63","81","9","15","3","21","209.69","C60H73ClFN11O7S","InChI=1S/C60H73ClFN11O7S/c1-38(62)57(77)72-28-27-71(33-43(72)20-23-63)55-46-21-26-70(49-15-9-12-41-11-8-14-47(61)52(41)49)35-48(46)66-59(68-55)80-36-44-13-10-25-69(44)24-6-7-29-79-30-22-51(75)67-54(60(3,4)5)58(78)73-34-45(74)31-50(73)56(76)64-32-40-16-18-42(19-17-40)53-39(2)65-37-81-53/h8-9,11-12,14-19,37,43-45,50,54,74H,1,6-7,10,13,20-22,24-36H2,2-5H3,(H,64,76)(H,67,75)/t43-,44-,45+,50-,54+/m0/s1","ZTFKFELOBVAACZ-JCKBJUPWSA-N"
"1661","P01116","KRAS G12C","VHL","","LC-5","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N",">10000","50","Degradation of KRAS G12C in SW1573 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1162.831","1161.5036852","6.77","82","9","16","3","22","218.92","C60H73ClFN11O8S","InChI=1S/C60H73ClFN11O8S/c1-38(62)57(77)72-25-24-71(33-43(72)18-21-63)55-46-19-23-70(49-13-7-10-41-9-6-12-47(61)52(41)49)35-48(46)66-59(68-55)81-36-44-11-8-22-69(44)26-28-80-30-29-79-27-20-51(75)67-54(60(3,4)5)58(78)73-34-45(74)31-50(73)56(76)64-32-40-14-16-42(17-15-40)53-39(2)65-37-82-53/h6-7,9-10,12-17,37,43-45,50,54,74H,1,8,11,18-20,22-36H2,2-5H3,(H,64,76)(H,67,75)/t43-,44-,45+,50-,54+/m0/s1","LHQBPRGJSOSPMT-JCKBJUPWSA-N"
"1662","P01116","KRAS G12C","VHL","","LC-6","C=C(F)C(=O)N1CCN(C2=NC(OC[C@@H]3CCCN3CCC(=O)NCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=NC3=C2CCN(C2=CC=CC4=CC=CC(Cl)=C24)C3)C[C@@H]1CC#N","","35","Degradation of KRAS G12C in NCI-H2030 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acscentsci.0c00411","1189.857","1188.51458423","6.17","84","9","16","4","22","238.79","C61H74ClFN12O8S","InChI=1S/C61H74ClFN12O8S/c1-38(63)58(80)74-28-27-73(33-43(74)18-22-64)56-46-19-25-72(49-13-7-10-41-9-6-12-47(62)53(41)49)35-48(46)68-60(70-56)83-36-44-11-8-24-71(44)26-20-51(77)65-23-30-82-29-21-52(78)69-55(61(3,4)5)59(81)75-34-45(76)31-50(75)57(79)66-32-40-14-16-42(17-15-40)54-39(2)67-37-84-54/h6-7,9-10,12-17,37,43-45,50,55,76H,1,8,11,18-21,23-36H2,2-5H3,(H,65,77)(H,66,79)(H,69,78)/t43-,44-,45+,50-,55+/m0/s1","ATYRLOQATKCPHD-CMBJQHFKSA-N"
"1663","P09874","PARP1","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","765.755","765.255853952","0.95","56","7","10","3","11","208.25","C39H36FN7O9","InChI=1S/C39H36FN7O9/c40-27-11-10-22(20-28-23-5-1-2-6-24(23)35(51)44-43-28)19-26(27)37(53)46-17-15-45(16-18-46)33(50)9-4-14-41-32(49)21-56-30-8-3-7-25-34(30)39(55)47(38(25)54)29-12-13-31(48)42-36(29)52/h1-3,5-8,10-11,19,29H,4,9,12-18,20-21H2,(H,41,49)(H,44,51)(H,42,48,52)","BTYCTSUTHLZLSM-UHFFFAOYSA-N"
"1664","P09874","PARP1","CRBN","","","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9400/>10000","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","793.809","793.28715408","1.67","58","7","10","3","13","208.25","C41H40FN7O9","InChI=1S/C41H40FN7O9/c42-29-13-12-24(22-30-25-7-3-4-8-26(25)37(53)46-45-30)21-28(29)39(55)48-19-17-47(18-20-48)35(52)11-2-1-5-16-43-34(51)23-58-32-10-6-9-27-36(32)41(57)49(40(27)56)31-14-15-33(50)44-38(31)54/h3-4,6-10,12-13,21,31H,1-2,5,11,14-20,22-23H2,(H,43,51)(H,46,53)(H,44,50,54)","JJLZWXLWGFJDBN-UHFFFAOYSA-N"
"1665","P09874","PARP1","CRBN","","","O=C(CCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5300/>10000","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","850.861","850.308617796","0.56","62","7","11","4","15","237.35","C43H43FN8O10","InChI=1S/C43H43FN8O10/c44-30-13-12-25(23-31-26-6-1-2-7-27(26)39(57)49-48-31)22-29(30)41(59)51-20-18-50(19-21-51)37(56)11-5-17-45-34(53)10-4-16-46-36(55)24-62-33-9-3-8-28-38(33)43(61)52(42(28)60)32-14-15-35(54)47-40(32)58/h1-3,6-9,12-13,22,32H,4-5,10-11,14-21,23-24H2,(H,45,53)(H,46,55)(H,49,57)(H,47,54,58)","KYSBUKQWFIVFLZ-UHFFFAOYSA-N"
"1666","P09874","PARP1","CRBN","","","O=C(CCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1900/8700","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","878.915","878.339917924","1.27","64","7","11","4","17","237.35","C45H47FN8O10","InChI=1S/C45H47FN8O10/c46-32-15-14-27(25-33-28-8-3-4-9-29(28)41(59)51-50-33)24-31(32)43(61)53-22-20-52(21-23-53)39(58)13-7-19-47-36(55)12-2-1-5-18-48-38(57)26-64-35-11-6-10-30-40(35)45(63)54(44(30)62)34-16-17-37(56)49-42(34)60/h3-4,6,8-11,14-15,24,34H,1-2,5,7,12-13,16-23,25-26H2,(H,47,55)(H,48,57)(H,51,59)(H,49,56,60)","WSSGMPYWFKPMIC-UHFFFAOYSA-N"
"1667","P09874","PARP1","CRBN","","","O=C(CCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1200/3100","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","878.915","878.339917924","1.27","64","7","11","4","17","237.35","C45H47FN8O10","InChI=1S/C45H47FN8O10/c46-32-15-14-27(25-33-28-8-3-4-9-29(28)41(59)51-50-33)24-31(32)43(61)53-22-20-52(21-23-53)39(58)13-2-1-5-18-47-36(55)12-7-19-48-38(57)26-64-35-11-6-10-30-40(35)45(63)54(44(30)62)34-16-17-37(56)49-42(34)60/h3-4,6,8-11,14-15,24,34H,1-2,5,7,12-13,16-23,25-26H2,(H,47,55)(H,48,57)(H,51,59)(H,49,56,60)","PTSMENJQCHOOPF-UHFFFAOYSA-N"
"1668","P09874","PARP1","CRBN","","","O=C(CCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","950/1500","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","906.969","906.371218052","1.99","66","7","11","4","19","237.35","C47H51FN8O10","InChI=1S/C47H51FN8O10/c48-34-17-16-29(27-35-30-10-5-6-11-31(30)43(61)53-52-35)26-33(34)45(63)55-24-22-54(23-25-55)41(60)15-4-2-8-20-49-38(57)14-3-1-7-21-50-40(59)28-66-37-13-9-12-32-42(37)47(65)56(46(32)64)36-18-19-39(58)51-44(36)62/h5-6,9-13,16-17,26,36H,1-4,7-8,14-15,18-25,27-28H2,(H,49,57)(H,50,59)(H,53,61)(H,51,58,62)","QKNJOGDPIXORAH-UHFFFAOYSA-N"
"1669","P09874","PARP1","CRBN","","","O=C(CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2200/7100","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","877.931","877.355902336","1.84","64","7","11","5","17","240.15","C45H48FN9O9","InChI=1S/C45H48FN9O9/c46-32-15-14-27(25-34-28-8-3-4-9-29(28)41(60)52-51-34)24-31(32)43(62)54-22-20-53(21-23-54)39(59)13-2-1-5-18-47-36(56)12-7-19-48-38(58)26-49-33-11-6-10-30-40(33)45(64)55(44(30)63)35-16-17-37(57)50-42(35)61/h3-4,6,8-11,14-15,24,35,49H,1-2,5,7,12-13,16-23,25-26H2,(H,47,56)(H,48,58)(H,52,60)(H,50,57,61)","MRZKHTBPTNPWLG-UHFFFAOYSA-N"
"1670","P09874","PARP1","CRBN","","","O=C(CCCCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1700/2200","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","905.985","905.387202464","2.55","66","7","11","5","19","240.15","C47H52FN9O9","InChI=1S/C47H52FN9O9/c48-34-17-16-29(27-36-30-10-5-6-11-31(30)43(62)54-53-36)26-33(34)45(64)56-24-22-55(23-25-56)41(61)15-4-2-8-20-49-38(58)14-3-1-7-21-50-40(60)28-51-35-13-9-12-32-42(35)47(66)57(46(32)65)37-18-19-39(59)52-44(37)63/h5-6,9-13,16-17,26,37,51H,1-4,7-8,14-15,18-25,27-28H2,(H,49,58)(H,50,60)(H,54,62)(H,52,59,63)","JXGRCLZSACFPIY-UHFFFAOYSA-N"
"1671","P09874","PARP1","CRBN","","","O=C(CCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000/>10000","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","792.825","792.303138492","1.78","58","7","10","4","13","211.05","C41H41FN8O8","InChI=1S/C41H41FN8O8/c42-29-13-12-24(23-31-25-6-1-2-7-26(25)37(54)47-46-31)22-28(29)39(56)49-20-18-48(19-21-49)35(53)11-4-3-10-33(51)44-17-16-43-30-9-5-8-27-36(30)41(58)50(40(27)57)32-14-15-34(52)45-38(32)55/h1-2,5-9,12-13,22,32,43H,3-4,10-11,14-21,23H2,(H,44,51)(H,47,54)(H,45,52,55)","PWDSZMLXEPMBDO-UHFFFAOYSA-N"
"1672","P09874","PARP1","CRBN","","","O=C(CCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","830/4100","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","820.879","820.33443862","2.86","60","7","10","4","15","211.05","C43H45FN8O8","InChI=1S/C43H45FN8O8/c44-31-15-14-26(25-33-27-8-5-6-9-28(27)39(56)49-48-33)24-30(31)41(58)51-22-20-50(21-23-51)37(55)13-4-2-1-3-12-35(53)46-19-18-45-32-11-7-10-29-38(32)43(60)52(42(29)59)34-16-17-36(54)47-40(34)57/h5-11,14-15,24,34,45H,1-4,12-13,16-23,25H2,(H,46,53)(H,49,56)(H,47,54,57)","TYQOLJVWTXQEFS-UHFFFAOYSA-N"
"1673","P09874","PARP1","CRBN","","","O=C(CCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","123/495","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","848.933","848.365738748","3.94","62","7","10","4","17","211.05","C45H49FN8O8","InChI=1S/C45H49FN8O8/c46-33-17-16-28(27-35-29-10-7-8-11-30(29)41(58)51-50-35)26-32(33)43(60)53-24-22-52(23-25-53)39(57)15-6-4-2-1-3-5-14-37(55)48-21-20-47-34-13-9-12-31-40(34)45(62)54(44(31)61)36-18-19-38(56)49-42(36)59/h7-13,16-17,26,36,47H,1-6,14-15,18-25,27H2,(H,48,55)(H,51,58)(H,49,56,59)","NRXQGGQADVPQBD-UHFFFAOYSA-N"
"1674","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","29/264","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","862.96","862.381388812","4.48","63","7","10","4","18","211.05","C46H51FN8O8","InChI=1S/C46H51FN8O8/c47-34-18-17-29(28-36-30-11-8-9-12-31(30)42(59)52-51-36)27-33(34)44(61)54-25-23-53(24-26-54)40(58)16-7-5-3-1-2-4-6-15-38(56)49-22-21-48-35-14-10-13-32-41(35)46(63)55(45(32)62)37-19-20-39(57)50-43(37)60/h8-14,17-18,27,37,48H,1-7,15-16,19-26,28H2,(H,49,56)(H,52,59)(H,50,57,60)","HWUJFLQBRISMOB-UHFFFAOYSA-N"
"1675","P09874","PARP1","CRBN","","SK-575","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","0.384/0.512/0.263",">99/>99/>99","Degradation of PARP1 in HCC1937/22RV1/MDA-MB-468 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8410/12300/4360","Inhibit growth of HCC1937/22RV1/MDA-MB-468 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","876.987","876.397038876","5.03","64","7","10","4","19","211.05","C47H53FN8O8","InChI=1S/C47H53FN8O8/c48-35-19-18-30(29-37-31-12-9-10-13-32(31)43(60)53-52-37)28-34(35)45(62)55-26-24-54(25-27-55)41(59)17-8-6-4-2-1-3-5-7-16-39(57)50-23-22-49-36-15-11-14-33-42(36)47(64)56(46(33)63)38-20-21-40(58)51-44(38)61/h9-15,18-19,28,38,49H,1-8,16-17,20-27,29H2,(H,50,57)(H,53,60)(H,51,58,61)","HPBWDZVXFSTVMR-UHFFFAOYSA-N"
"1675","P09874","PARP1","CRBN","","SK-575","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","0.578/1.08/0.228",">99/>99/>99","Degradation of PARP1 in PC-3/LNCaP/MDA-MB-231 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5140/1440/4790","Inhibit growth of PC-3/LNCaP/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","876.987","876.397038876","5.03","64","7","10","4","19","211.05","C47H53FN8O8","InChI=1S/C47H53FN8O8/c48-35-19-18-30(29-37-31-12-9-10-13-32(31)43(60)53-52-37)28-34(35)45(62)55-26-24-54(25-27-55)41(59)17-8-6-4-2-1-3-5-7-16-39(57)50-23-22-49-36-15-11-14-33-42(36)47(64)56(46(33)63)38-20-21-40(58)51-44(38)61/h9-15,18-19,28,38,49H,1-8,16-17,20-27,29H2,(H,50,57)(H,53,60)(H,51,58,61)","HPBWDZVXFSTVMR-UHFFFAOYSA-N"
"1675","P09874","PARP1","CRBN","","SK-575","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","1.26/6.72/0.509",">99/>99/>99","Degradation of PARP1 in MDA-MB-436/Capan-1/SW620 cells after 24 h treatment","","","2.3","IC50 was tested using a PARP1 activity assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19/56/5130","Inhibit growth of MDA-MB-436/Capan-1/SW620 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","876.987","876.397038876","5.03","64","7","10","4","19","211.05","C47H53FN8O8","InChI=1S/C47H53FN8O8/c48-35-19-18-30(29-37-31-12-9-10-13-32(31)43(60)53-52-37)28-34(35)45(62)55-26-24-54(25-27-55)41(59)17-8-6-4-2-1-3-5-7-16-39(57)50-23-22-49-36-15-11-14-33-42(36)47(64)56(46(33)63)38-20-21-40(58)51-44(38)61/h9-15,18-19,28,38,49H,1-8,16-17,20-27,29H2,(H,50,57)(H,53,60)(H,51,58,61)","HPBWDZVXFSTVMR-UHFFFAOYSA-N"
"1676","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21/87","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","891.014","890.41268894","5.57","65","7","10","4","20","211.05","C48H55FN8O8","InChI=1S/C48H55FN8O8/c49-36-20-19-31(30-38-32-13-10-11-14-33(32)44(61)54-53-38)29-35(36)46(63)56-27-25-55(26-28-56)42(60)18-9-7-5-3-1-2-4-6-8-17-40(58)51-24-23-50-37-16-12-15-34-43(37)48(65)57(47(34)64)39-21-22-41(59)52-45(39)62/h10-16,19-20,29,39,50H,1-9,17-18,21-28,30H2,(H,51,58)(H,54,61)(H,52,59,62)","VYUINQXVAZLNDI-UHFFFAOYSA-N"
"1677","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25/118","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","905.041","904.428339004","6.11","66","7","10","4","21","211.05","C49H57FN8O8","InChI=1S/C49H57FN8O8/c50-37-21-20-32(31-39-33-14-11-12-15-34(33)45(62)55-54-39)30-36(37)47(64)57-28-26-56(27-29-57)43(61)19-10-8-6-4-2-1-3-5-7-9-18-41(59)52-25-24-51-38-17-13-16-35-44(38)49(66)58(48(35)65)40-22-23-42(60)53-46(40)63/h11-17,20-21,30,40,51H,1-10,18-19,22-29,31H2,(H,52,59)(H,55,62)(H,53,60,63)","WTSVLYSMIRPZJM-UHFFFAOYSA-N"
"1678","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39/131","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","905.041","904.428339004","5.74","66","7","10","4","21","211.05","C49H57FN8O8","InChI=1S/C49H57FN8O8/c50-37-21-20-32(31-39-33-14-9-10-15-34(33)45(62)55-54-39)30-36(37)47(64)57-28-26-56(27-29-57)43(61)19-8-6-4-2-1-3-5-7-18-41(59)52-25-12-11-24-51-38-17-13-16-35-44(38)49(66)58(48(35)65)40-22-23-42(60)53-46(40)63/h9-10,13-17,20-21,30,40,51H,1-8,11-12,18-19,22-29,31H2,(H,52,59)(H,55,62)(H,53,60,63)","RSEHHFRVWZFJCI-UHFFFAOYSA-N"
"1679","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42/110","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","933.095","932.459639132","6.45","68","7","10","4","23","211.05","C51H61FN8O8","InChI=1S/C51H61FN8O8/c52-39-23-22-34(33-41-35-16-11-12-17-36(35)47(64)57-56-41)32-38(39)49(66)59-30-28-58(29-31-59)45(63)21-10-6-4-2-1-3-5-9-20-43(61)54-27-14-8-7-13-26-53-40-19-15-18-37-46(40)51(68)60(50(37)67)42-24-25-44(62)55-48(42)65/h11-12,15-19,22-23,32,42,53H,1-10,13-14,20-21,24-31,33H2,(H,54,61)(H,57,64)(H,55,62,65)","MWQDZCRKEUWJTB-UHFFFAOYSA-N"
"1680","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","47/120","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","921.04","920.423253624","4.88","67","7","11","4","22","220.28","C49H57FN8O9","InChI=1S/C49H57FN8O9/c50-37-19-18-32(31-39-33-12-9-10-13-34(33)45(62)55-54-39)30-36(37)47(64)57-26-24-56(25-27-57)43(61)17-8-6-4-2-1-3-5-7-16-41(59)52-23-29-67-28-22-51-38-15-11-14-35-44(38)49(66)58(48(35)65)40-20-21-42(60)53-46(40)63/h9-15,18-19,30,40,51H,1-8,16-17,20-29,31H2,(H,52,59)(H,55,62)(H,53,60,63)","XBRQJGDNKCUJBA-UHFFFAOYSA-N"
"1681","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","64/134","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","965.093","964.449468372","4.73","70","7","12","4","25","229.51","C51H61FN8O10","InChI=1S/C51H61FN8O10/c52-39-19-18-34(33-41-35-12-9-10-13-36(35)47(64)57-56-41)32-38(39)49(66)59-26-24-58(25-27-59)45(63)17-8-6-4-2-1-3-5-7-16-43(61)54-23-29-70-31-30-69-28-22-53-40-15-11-14-37-46(40)51(68)60(50(37)67)42-20-21-44(62)55-48(42)65/h9-15,18-19,32,42,53H,1-8,16-17,20-31,33H2,(H,54,61)(H,57,64)(H,55,62,65)","ZSRMSRWPRDTNRK-UHFFFAOYSA-N"
"1682","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCCOCCOCCOCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","65/154","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","1037.2","1036.50698325","5.3","75","7","13","4","30","238.74","C55H69FN8O11","InChI=1S/C55H69FN8O11/c56-43-21-20-38(37-45-39-14-9-10-15-40(39)51(68)61-60-45)36-42(43)53(70)63-28-26-62(27-29-63)49(67)19-8-6-4-2-1-3-5-7-18-47(65)58-25-13-31-74-33-35-75-34-32-73-30-12-24-57-44-17-11-16-41-50(44)55(72)64(54(41)71)46-22-23-48(66)59-52(46)69/h9-11,14-17,20-21,36,46,57H,1-8,12-13,18-19,22-35,37H2,(H,58,65)(H,61,68)(H,59,66,69)","JWWFHTXLXMDQCD-UHFFFAOYSA-N"
"1683","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35/159","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","876.987","876.397038876","4.47","64","7","10","4","19","211.05","C47H53FN8O8","InChI=1S/C47H53FN8O8/c48-37-18-15-30(28-38-32-11-9-10-12-33(32)43(60)53-52-38)27-36(37)45(62)55-25-23-54(24-26-55)42(59)14-8-6-4-2-1-3-5-7-13-40(57)50-22-21-49-31-16-17-34-35(29-31)47(64)56(46(34)63)39-19-20-41(58)51-44(39)61/h9-12,15-18,27,29,39,49H,1-8,13-14,19-26,28H2,(H,50,57)(H,53,60)(H,51,58,61)","PXZCZPPSJPGZNX-UHFFFAOYSA-N"
"1684","P09874","PARP1","CRBN","","","O=C(CCCCCCCCCCC(=O)N1CCN(C(=O)C2=CC(CC3=N[NH]C(=O)C4=CC=CC=C34)=CC=C2F)CC1)NCCNC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","92/194","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","863.004","862.41777432","4.53","63","7","9","4","19","193.98","C47H55FN8O7","InChI=1S/C47H55FN8O7/c48-37-19-18-31(29-39-32-12-9-10-13-33(32)44(60)53-52-39)28-35(37)46(62)55-26-24-54(25-27-55)43(59)17-8-6-4-2-1-3-5-7-16-41(57)50-23-22-49-38-15-11-14-34-36(38)30-56(47(34)63)40-20-21-42(58)51-45(40)61/h9-15,18-19,28,40,49H,1-8,16-17,20-27,29-30H2,(H,50,57)(H,53,60)(H,51,58,61)","CZPBCFZPTYBEHY-UHFFFAOYSA-N"
"1685","P09874","PARP1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)N3CCN(C(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","54/87","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","991.244","990.483745704","7.36","71","7","10","4","20","198.0","C54H67FN8O7S","InChI=1S/C54H67FN8O7S/c1-35-48(71-34-57-35)38-22-19-36(20-23-38)32-56-51(68)45-31-39(64)33-63(45)53(70)49(54(2,3)4)58-46(65)17-11-9-7-5-6-8-10-12-18-47(66)61-25-27-62(28-26-61)52(69)42-29-37(21-24-43(42)55)30-44-40-15-13-14-16-41(40)50(67)60-59-44/h13-16,19-24,29,34,39,45,49,64H,5-12,17-18,25-28,30-33H2,1-4H3,(H,56,68)(H,58,65)(H,60,67)/t39-,45+,49-/m1/s1","KMYNQEXDNUVOBZ-QZUXPVMFSA-N"
"1686","P09874","PARP1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)CCCCCCCCCCC(=O)N3CCN(C(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1200/1600","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","1048.296","1047.50520942","6.71","75","7","11","5","22","227.1","C56H70FN9O8S","InChI=1S/C56H70FN9O8S/c1-36-50(75-35-60-36)39-22-19-37(20-23-39)32-59-53(72)46-31-40(67)34-66(46)55(74)51(56(2,3)4)61-48(69)33-58-47(68)17-11-9-7-5-6-8-10-12-18-49(70)64-25-27-65(28-26-64)54(73)43-29-38(21-24-44(43)57)30-45-41-15-13-14-16-42(41)52(71)63-62-45/h13-16,19-24,29,35,40,46,51,67H,5-12,17-18,25-28,30-34H2,1-4H3,(H,58,68)(H,59,72)(H,61,69)(H,63,71)/t40-,46+,51-/m1/s1","VDMFUELIRGBPHD-DEYDXPIJSA-N"
"1687","P09874","PARP1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)CCCCCCCCCCC(=O)N3CCN(C(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","680/870","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","1076.35","1075.53650955","6.97","77","7","11","5","24","227.1","C58H74FN9O8S","InChI=1S/C58H74FN9O8S/c1-38-52(77-37-62-38)41-24-21-39(22-25-41)35-61-55(74)48-34-42(69)36-68(48)57(76)53(58(2,3)4)63-50(71)19-15-27-60-49(70)18-11-9-7-5-6-8-10-12-20-51(72)66-28-30-67(31-29-66)56(75)45-32-40(23-26-46(45)59)33-47-43-16-13-14-17-44(43)54(73)65-64-47/h13-14,16-17,21-26,32,37,42,48,53,69H,5-12,15,18-20,27-31,33-36H2,1-4H3,(H,60,70)(H,61,74)(H,63,71)(H,65,73)/t42-,48+,53-/m1/s1","VYCNLFMCPKZXRR-UBSCPIRJSA-N"
"1688","P09874","PARP1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCNC(=O)CCCCCCCCCCC(=O)N3CCN(C(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","120/170","Inhibit growth of MDA-MB-436/Capan-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c00821","1104.404","1103.56780968","7.68","79","7","11","5","26","227.1","C60H78FN9O8S","InChI=1S/C60H78FN9O8S/c1-40-54(79-39-64-40)43-26-23-41(24-27-43)37-63-57(76)50-36-44(71)38-70(50)59(78)55(60(2,3)4)65-52(73)21-13-11-17-29-62-51(72)20-12-9-7-5-6-8-10-14-22-53(74)68-30-32-69(33-31-68)58(77)47-34-42(25-28-48(47)61)35-49-45-18-15-16-19-46(45)56(75)67-66-49/h15-16,18-19,23-28,34,39,44,50,55,71H,5-14,17,20-22,29-33,35-38H2,1-4H3,(H,62,72)(H,63,76)(H,65,73)(H,67,75)/t44-,50+,55-/m1/s1","BLRXMETYTMSLHB-SJZQNCIOSA-N"
"1689","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","15/45/93","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","756.799","756.293242504","3.72","56","9","12","2","8","165.45","C40H37FN10O5","InChI=1S/C40H37FN10O5/c41-25-6-1-5-24(21-25)29-10-4-16-49(29)34-14-13-32-43-22-31(51(32)46-34)27-8-3-11-33(44-27)47-17-19-48(20-18-47)36(53)23-42-28-9-2-7-26-37(28)40(56)50(39(26)55)30-12-15-35(52)45-38(30)54/h1-3,5-9,11,13-14,21-22,29-30,42H,4,10,12,15-20,23H2,(H,45,52,54)/t29-,30?/m1/s1","FPRAOLVAUXBFAM-IDCGIGBZSA-N"
"1690","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","9/15/65","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","770.826","770.308892568","3.62","57","9","12","2","9","165.45","C41H39FN10O5","InChI=1S/C41H39FN10O5/c42-26-6-1-5-25(23-26)30-10-4-18-50(30)35-14-13-33-44-24-32(52(33)47-35)28-8-3-11-34(45-28)48-19-21-49(22-20-48)37(54)16-17-43-29-9-2-7-27-38(29)41(57)51(40(27)56)31-12-15-36(53)46-39(31)55/h1-3,5-9,11,13-14,23-24,30-31,43H,4,10,12,15-22H2,(H,46,53,55)/t30-,31?/m1/s1","YICPFQIGJSEBNS-PBBFAOSKSA-N"
"1691","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","12/63/94","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","784.853","784.324542632","3.98","58","9","12","2","10","165.45","C42H41FN10O5","InChI=1S/C42H41FN10O5/c43-27-7-1-6-26(24-27)31-11-5-19-51(31)36-16-15-34-45-25-33(53(34)48-36)29-9-3-12-35(46-29)49-20-22-50(23-21-49)38(55)13-4-18-44-30-10-2-8-28-39(30)42(58)52(41(28)57)32-14-17-37(54)47-40(32)56/h1-3,6-10,12,15-16,24-25,31-32,44H,4-5,11,13-14,17-23H2,(H,47,54,56)/t31-,32?/m1/s1","PQXMLGVMAGAZND-XGDNGBMYSA-N"
"1692","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","20/69/93","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","798.88","798.340192696","4.34","59","9","12","2","11","165.45","C43H43FN10O5","InChI=1S/C43H43FN10O5/c44-28-8-3-7-27(25-28)32-12-6-20-52(32)37-17-16-35-46-26-34(54(35)49-37)30-10-5-13-36(47-30)50-21-23-51(24-22-50)39(56)14-1-2-19-45-31-11-4-9-29-40(31)43(59)53(42(29)58)33-15-18-38(55)48-41(33)57/h3-5,7-11,13,16-17,25-26,32-33,45H,1-2,6,12,14-15,18-24H2,(H,48,55,57)/t32-,33?/m1/s1","FRMFOBIMNHXGPY-KWRHIPAJSA-N"
"1693","P04629","TRKA","CRBN","","CG416","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","0.48/1.26","","Degradation of TPM3-TRKA/TRKA in KM12/HEL cells after 6 h treatment","18/65/96","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","2.1","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.4","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","812.907","812.35584276","4.69","60","9","12","2","12","165.45","C44H45FN10O5","InChI=1S/C44H45FN10O5/c45-29-9-4-8-28(26-29)33-13-7-21-53(33)38-18-17-36-47-27-35(55(36)50-38)31-11-6-14-37(48-31)51-22-24-52(25-23-51)40(57)15-2-1-3-20-46-32-12-5-10-30-41(32)44(60)54(43(30)59)34-16-19-39(56)49-42(34)58/h4-6,8-12,14,17-18,26-27,33-34,46H,1-3,7,13,15-16,19-25H2,(H,49,56,58)/t33-,34?/m1/s1","YTPXNCADDOOFPA-BONSOQDYSA-N"
"1693","Q16620","TRKB","CRBN","","CG416","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","111.9","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.4","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","812.907","812.35584276","4.69","60","9","12","2","12","165.45","C44H45FN10O5","InChI=1S/C44H45FN10O5/c45-29-9-4-8-28(26-29)33-13-7-21-53(33)38-18-17-36-47-27-35(55(36)50-38)31-11-6-14-37(48-31)51-22-24-52(25-23-51)40(57)15-2-1-3-20-46-32-12-5-10-30-41(32)44(60)54(43(30)59)34-16-19-39(56)49-42(34)58/h4-6,8-12,14,17-18,26-27,33-34,46H,1-3,7,13,15-16,19-25H2,(H,49,56,58)/t33-,34?/m1/s1","YTPXNCADDOOFPA-BONSOQDYSA-N"
"1693","Q16288","TRKC","CRBN","","CG416","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","18","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.4","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","812.907","812.35584276","4.69","60","9","12","2","12","165.45","C44H45FN10O5","InChI=1S/C44H45FN10O5/c45-29-9-4-8-28(26-29)33-13-7-21-53(33)38-18-17-36-47-27-35(55(36)50-38)31-11-6-14-37(48-31)51-22-24-52(25-23-51)40(57)15-2-1-3-20-46-32-12-5-10-30-41(32)44(60)54(43(30)59)34-16-19-39(56)49-42(34)58/h4-6,8-12,14,17-18,26-27,33-34,46H,1-3,7,13,15-16,19-25H2,(H,49,56,58)/t33-,34?/m1/s1","YTPXNCADDOOFPA-BONSOQDYSA-N"
"1694","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","21/23/90","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","826.934","826.371492824","5.24","61","9","12","2","13","165.45","C45H47FN10O5","InChI=1S/C45H47FN10O5/c46-30-10-5-9-29(27-30)34-14-8-22-54(34)39-19-18-37-48-28-36(56(37)51-39)32-12-7-15-38(49-32)52-23-25-53(26-24-52)41(58)16-3-1-2-4-21-47-33-13-6-11-31-42(33)45(61)55(44(31)60)35-17-20-40(57)50-43(35)59/h5-7,9-13,15,18-19,27-28,34-35,47H,1-4,8,14,16-17,20-26H2,(H,50,57,59)/t34-,35?/m1/s1","FUIPOZKPQFMWHV-IFDNYZKCSA-N"
"1695","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","20/21/83","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","840.961","840.387142888","5.78","62","9","12","2","14","165.45","C46H49FN10O5","InChI=1S/C46H49FN10O5/c47-31-11-6-10-30(28-31)35-15-9-23-55(35)40-20-19-38-49-29-37(57(38)52-40)33-13-8-16-39(50-33)53-24-26-54(27-25-53)42(59)17-4-2-1-3-5-22-48-34-14-7-12-32-43(34)46(62)56(45(32)61)36-18-21-41(58)51-44(36)60/h6-8,10-14,16,19-20,28-29,35-36,48H,1-5,9,15,17-18,21-27H2,(H,51,58,60)/t35-,36?/m1/s1","UUXJQTJKYDQCKR-RERZGLEZSA-N"
"1696","P04629","TRKA","CRBN","","CG428","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","0.36/2.23","","Degradation of TPM3-TRKA/TRKA in KM12/HEL cells after 6 h treatment","46/82/96","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","1","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.9","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","814.879","814.335107316","3.48","60","9","13","2","12","174.68","C43H43FN10O6","InChI=1S/C43H43FN10O6/c44-28-6-1-5-27(25-28)32-10-4-18-52(32)37-14-13-35-46-26-34(54(35)49-37)30-8-3-11-36(47-30)50-19-21-51(22-20-50)39(56)16-23-60-24-17-45-31-9-2-7-29-40(31)43(59)53(42(29)58)33-12-15-38(55)48-41(33)57/h1-3,5-9,11,13-14,25-26,32-33,45H,4,10,12,15-24H2,(H,48,55,57)/t32-,33?/m1/s1","FWANKJAOTQAHHR-KWRHIPAJSA-N"
"1696","Q16620","TRKB","CRBN","","CG428","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","28","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.9","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","814.879","814.335107316","3.48","60","9","13","2","12","174.68","C43H43FN10O6","InChI=1S/C43H43FN10O6/c44-28-6-1-5-27(25-28)32-10-4-18-52(32)37-14-13-35-46-26-34(54(35)49-37)30-8-3-11-36(47-30)50-19-21-51(22-20-50)39(56)16-23-60-24-17-45-31-9-2-7-29-40(31)43(59)53(42(29)58)33-12-15-38(55)48-41(33)57/h1-3,5-9,11,13-14,25-26,32-33,45H,4,10,12,15-24H2,(H,48,55,57)/t32-,33?/m1/s1","FWANKJAOTQAHHR-KWRHIPAJSA-N"
"1696","Q16288","TRKC","CRBN","","CG428","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","4.2","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.9","Inhibit growth of KM12 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","814.879","814.335107316","3.48","60","9","13","2","12","174.68","C43H43FN10O6","InChI=1S/C43H43FN10O6/c44-28-6-1-5-27(25-28)32-10-4-18-52(32)37-14-13-35-46-26-34(54(35)49-37)30-8-3-11-36(47-30)50-19-21-51(22-20-50)39(56)16-23-60-24-17-45-31-9-2-7-29-40(31)43(59)53(42(29)58)33-12-15-38(55)48-41(33)57/h1-3,5-9,11,13-14,25-26,32-33,45H,4,10,12,15-24H2,(H,48,55,57)/t32-,33?/m1/s1","FWANKJAOTQAHHR-KWRHIPAJSA-N"
"1697","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","30/56/95","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","858.932","858.361322064","3.33","63","9","14","2","15","183.91","C45H47FN10O7","InChI=1S/C45H47FN10O7/c46-30-6-1-5-29(27-30)34-10-4-18-54(34)39-14-13-37-48-28-36(56(37)51-39)32-8-3-11-38(49-32)52-19-21-53(22-20-52)41(58)16-23-62-25-26-63-24-17-47-33-9-2-7-31-42(33)45(61)55(44(31)60)35-12-15-40(57)50-43(35)59/h1-3,5-9,11,13-14,27-28,34-35,47H,4,10,12,15-26H2,(H,50,57,59)/t34-,35?/m1/s1","IQQDXLBSPZWBKO-IFDNYZKCSA-N"
"1698","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","22/28/86","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","902.985","902.387536812","3.18","66","9","15","2","18","193.14","C47H51FN10O8","InChI=1S/C47H51FN10O8/c48-32-6-1-5-31(29-32)36-10-4-18-56(36)41-14-13-39-50-30-38(58(39)53-41)34-8-3-11-40(51-34)54-19-21-55(22-20-54)43(60)16-23-64-25-27-66-28-26-65-24-17-49-35-9-2-7-33-44(35)47(63)57(46(33)62)37-12-15-42(59)52-45(37)61/h1-3,5-9,11,13-14,29-30,36-37,49H,4,10,12,15-28H2,(H,52,59,61)/t36-,37?/m1/s1","LYOSHDFVUGOVCI-RKROREJRSA-N"
"1699","P04629","TRKA","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCC(=O)N4CCN(C5=CC=CC(C6=CN=C7C=CC(N8CCC[C@@H]8C8=CC=CC(F)=C8)=NN67)=N5)CC4)=C3C2=O)C(=O)N1","","","","22/40/91","% TPM3-TRKA degradation in KM12 cells after 6 h treatment at 0.1/1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01342","947.038","946.41375156","3.03","69","9","16","2","21","202.37","C49H55FN10O9","InChI=1S/C49H55FN10O9/c50-34-6-1-5-33(31-34)38-10-4-18-58(38)43-14-13-41-52-32-40(60(41)55-43)36-8-3-11-42(53-36)56-19-21-57(22-20-56)45(62)16-23-66-25-27-68-29-30-69-28-26-67-24-17-51-37-9-2-7-35-46(37)49(65)59(48(35)64)39-12-15-44(61)54-47(39)63/h1-3,5-9,11,13-14,31-32,38-39,51H,4,10,12,15-30H2,(H,54,61,63)/t38-,39?/m1/s1","CXNAYSUWWHDMPE-SWGHGFEUSA-N"
"1700","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","21","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1003.281","1002.53609495","4.06","71","7","16","4","23","214.32","C51H74N10O9S","InChI=1S/C51H74N10O9S/c1-34(2)41-15-16-61-45(41)48(53-32-55-61)56-38-11-13-39(14-12-38)58-17-19-59(20-18-58)44(64)31-70-26-24-68-22-21-67-23-25-69-30-43(63)57-47(51(4,5)6)50(66)60-29-40(62)27-42(60)49(65)52-28-36-7-9-37(10-8-36)46-35(3)54-33-71-46/h7-10,15-16,32-34,38-40,42,47,62H,11-14,17-31H2,1-6H3,(H,52,65)(H,57,63)(H,53,55,56)/t38-,39+,40-,42+,47-/m1/s1","YUNOOMHEHSHBTQ-HFXLYGLKSA-N"
"1701","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","51","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1047.334","1046.5623097","3.91","74","7","17","4","26","223.55","C53H78N10O10S","InChI=1S/C53H78N10O10S/c1-36(2)43-15-16-63-47(43)50(55-34-57-63)58-40-11-13-41(14-12-40)60-17-19-61(20-18-60)46(66)33-73-28-26-71-24-22-69-21-23-70-25-27-72-32-45(65)59-49(53(4,5)6)52(68)62-31-42(64)29-44(62)51(67)54-30-38-7-9-39(10-8-38)48-37(3)56-35-74-48/h7-10,15-16,34-36,40-42,44,49,64H,11-14,17-33H2,1-6H3,(H,54,67)(H,59,65)(H,55,57,58)/t40-,41+,42-,44+,49-/m1/s1","YWAJRORGSSQFFP-KMXBHADPSA-N"
"1702","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","33","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1091.387","1090.58852444","3.76","77","7","18","4","29","232.78","C55H82N10O11S","InChI=1S/C55H82N10O11S/c1-38(2)45-15-16-65-49(45)52(57-36-59-65)60-42-11-13-43(14-12-42)62-17-19-63(20-18-62)48(68)35-76-30-28-74-26-24-72-22-21-71-23-25-73-27-29-75-34-47(67)61-51(55(4,5)6)54(70)64-33-44(66)31-46(64)53(69)56-32-40-7-9-41(10-8-40)50-39(3)58-37-77-50/h7-10,15-16,36-38,42-44,46,51,66H,11-14,17-35H2,1-6H3,(H,56,69)(H,61,67)(H,57,59,60)/t42-,43+,44-,46+,51-/m1/s1","WJWGGDOUIMBBCZ-HPEYPNPYSA-N"
"1703","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","34","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","801.946","801.41735972","2.43","58","7","14","3","18","189.04","C41H55N9O8","InChI=1S/C41H55N9O8/c1-27(2)30-12-15-49-37(30)38(43-26-44-49)45-28-6-8-29(9-7-28)47-16-18-48(19-17-47)35(52)13-20-56-22-24-58-25-23-57-21-14-42-32-5-3-4-31-36(32)41(55)50(40(31)54)33-10-11-34(51)46-39(33)53/h3-5,12,15,26-29,33,42H,6-11,13-14,16-25H2,1-2H3,(H,43,44,45)(H,46,51,53)/t28-,29+,33?","NWCABRYLZNBNEV-ZWEIZTMOSA-N"
"1704","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","50","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","845.999","845.443574468","2.28","61","7","15","3","21","198.27","C43H59N9O9","InChI=1S/C43H59N9O9/c1-29(2)32-12-15-51-39(32)40(45-28-46-51)47-30-6-8-31(9-7-30)49-16-18-50(19-17-49)37(54)13-20-58-22-24-60-26-27-61-25-23-59-21-14-44-34-5-3-4-33-38(34)43(57)52(42(33)56)35-10-11-36(53)48-41(35)55/h3-5,12,15,28-31,35,44H,6-11,13-14,16-27H2,1-2H3,(H,45,46,47)(H,48,53,55)/t30-,31+,35?","VKOYXFKXWUQAMB-XRCHNQPISA-N"
"1705","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","33","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","890.052","889.469789216","2.13","64","7","16","3","24","207.5","C45H63N9O10","InChI=1S/C45H63N9O10/c1-31(2)34-12-15-53-41(34)42(47-30-48-53)49-32-6-8-33(9-7-32)51-16-18-52(19-17-51)39(56)13-20-60-22-24-62-26-28-64-29-27-63-25-23-61-21-14-46-36-5-3-4-35-40(36)45(59)54(44(35)58)37-10-11-38(55)50-43(37)57/h3-5,12,15,30-33,37,46H,6-11,13-14,16-29H2,1-2H3,(H,47,48,49)(H,50,55,57)/t32-,33+,37?","ZVCUEMSDCKWDQY-MBSVEICTSA-N"
"1706","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNC(=O)CCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","24","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1000.281","999.536429296","3.5","71","7","15","5","21","224.96","C51H73N11O8S","InChI=1S/C51H73N11O8S/c1-33(2)40-17-19-62-45(40)48(54-31-56-62)57-37-11-13-38(14-12-37)59-20-22-60(23-21-59)44(66)16-15-42(64)52-18-24-69-25-26-70-30-43(65)58-47(51(4,5)6)50(68)61-29-39(63)27-41(61)49(67)53-28-35-7-9-36(10-8-35)46-34(3)55-32-71-46/h7-10,17,19,31-33,37-39,41,47,63H,11-16,18,20-30H2,1-6H3,(H,52,64)(H,53,67)(H,58,65)(H,54,56,57)/t37-,38+,39-,41+,47-/m1/s1","GABSFUATYGLJFI-RKIHMSOOSA-N"
"1707","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)CCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","25","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1044.334","1043.56264404","3.35","74","7","16","5","24","234.19","C53H77N11O9S","InChI=1S/C53H77N11O9S/c1-35(2)42-17-19-64-47(42)50(56-33-58-64)59-39-11-13-40(14-12-39)61-20-22-62(23-21-61)46(68)16-15-44(66)54-18-24-71-25-26-72-27-28-73-32-45(67)60-49(53(4,5)6)52(70)63-31-41(65)29-43(63)51(69)55-30-37-7-9-38(10-8-37)48-36(3)57-34-74-48/h7-10,17,19,33-35,39-41,43,49,65H,11-16,18,20-32H2,1-6H3,(H,54,66)(H,55,69)(H,60,67)(H,56,58,59)/t39-,40+,41-,43+,49-/m1/s1","IFCPJXPVZMDESB-OVKKYJFHSA-N"
"1708","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)CCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","19","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","1088.387","1087.58885879","3.21","77","7","17","5","27","243.42","C55H81N11O10S","InChI=1S/C55H81N11O10S/c1-37(2)44-17-19-66-49(44)52(58-35-60-66)61-41-11-13-42(14-12-41)63-20-22-64(23-21-63)48(70)16-15-46(68)56-18-24-73-25-26-74-27-28-75-29-30-76-34-47(69)62-51(55(4,5)6)54(72)65-33-43(67)31-45(65)53(71)57-32-39-7-9-40(10-8-39)50-38(3)59-36-77-50/h7-10,17,19,35-37,41-43,45,51,67H,11-16,18,20-34H2,1-6H3,(H,56,68)(H,57,71)(H,62,69)(H,58,60,61)/t41-,42+,43-,45+,51-/m1/s1","LFOIIHKYBYUQAR-SSBGEIKESA-N"
"1709","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNC(=O)CCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","15","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","940.229","939.515299928","4.06","67","7","13","5","17","206.5","C49H69N11O6S","InChI=1S/C49H69N11O6S/c1-31(2)38-19-21-60-43(38)46(52-29-54-60)55-35-13-15-36(16-14-35)57-22-24-58(25-23-57)42(64)18-17-40(62)50-20-7-8-41(63)56-45(49(4,5)6)48(66)59-28-37(61)26-39(59)47(65)51-27-33-9-11-34(12-10-33)44-32(3)53-30-67-44/h9-12,19,21,29-31,35-37,39,45,61H,7-8,13-18,20,22-28H2,1-6H3,(H,50,62)(H,51,65)(H,56,63)(H,52,54,55)/t35-,36+,37-,39+,45-/m1/s1","GQOXYAWWUOXXBT-QXJHHGFPSA-N"
"1710","Q9Y616","IRAK3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCNC(=O)CCC(=O)N3CCN([C@H]4CC[C@@H](NC5=NC=NN6C=CC(C(C)C)=C56)CC4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","5.9","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","982.31","981.56225012","5.31","70","7","13","5","20","206.5","C52H75N11O6S","InChI=1S/C52H75N11O6S/c1-34(2)41-22-24-63-46(41)49(55-32-57-63)58-38-16-18-39(19-17-38)60-25-27-61(28-26-60)45(67)21-20-43(65)53-23-10-8-7-9-11-44(66)59-48(52(4,5)6)51(69)62-31-40(64)29-42(62)50(68)54-30-36-12-14-37(15-13-36)47-35(3)56-33-70-47/h12-15,22,24,32-34,38-40,42,48,64H,7-11,16-21,23,25-31H2,1-6H3,(H,53,65)(H,54,68)(H,59,66)(H,55,57,58)/t38-,39+,40-,42+,48-/m1/s1","PDSUGWAIWCZKFS-SRCMZFQMSA-N"
"1711","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)NCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","10","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","828.972","828.428258752","1.82","60","7","14","4","18","208.91","C42H56N10O8","InChI=1S/C42H56N10O8/c1-27(2)30-14-17-51-38(30)39(45-26-46-51)47-28-6-8-29(9-7-28)49-18-20-50(21-19-49)36(55)13-12-34(53)44-16-23-60-25-24-59-22-15-43-32-5-3-4-31-37(32)42(58)52(41(31)57)33-10-11-35(54)48-40(33)56/h3-5,14,17,26-29,33,43H,6-13,15-16,18-25H2,1-2H3,(H,44,53)(H,45,46,47)(H,48,54,56)/t28-,29+,33?","KDSWYNPXRVTAIR-ZWEIZTMOSA-N"
"1712","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","21","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","873.025","872.4544735","1.67","63","7","15","4","21","218.14","C44H60N10O9","InChI=1S/C44H60N10O9/c1-29(2)32-14-17-53-40(32)41(47-28-48-53)49-30-6-8-31(9-7-30)51-18-20-52(21-19-51)38(57)13-12-36(55)46-16-23-62-25-27-63-26-24-61-22-15-45-34-5-3-4-33-39(34)44(60)54(43(33)59)35-10-11-37(56)50-42(35)58/h3-5,14,17,28-31,35,45H,6-13,15-16,18-27H2,1-2H3,(H,46,55)(H,47,48,49)(H,50,56,58)/t30-,31+,35?","NACJXPBPXDVAEF-XRCHNQPISA-N"
"1713","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)NCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","22","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","917.078","916.480688248","1.53","66","7","16","4","24","227.37","C46H64N10O10","InChI=1S/C46H64N10O10/c1-31(2)34-14-17-55-42(34)43(49-30-50-55)51-32-6-8-33(9-7-32)53-18-20-54(21-19-53)40(59)13-12-38(57)48-16-23-64-25-27-66-29-28-65-26-24-63-22-15-47-36-5-3-4-35-41(36)46(62)56(45(35)61)37-10-11-39(58)52-44(37)60/h3-5,14,17,30-33,37,47H,6-13,15-16,18-29H2,1-2H3,(H,48,57)(H,49,50,51)(H,52,58,60)/t32-,33+,37?","ZWNQTQJUJKYBPF-MBSVEICTSA-N"
"1714","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","13","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","768.92","768.407129384","2.83","56","7","12","4","14","190.45","C40H52N10O6","InChI=1S/C40H52N10O6/c1-25(2)28-16-19-49-36(28)37(43-24-44-49)45-26-8-10-27(11-9-26)47-20-22-48(23-21-47)34(53)15-14-32(51)42-18-4-3-17-41-30-7-5-6-29-35(30)40(56)50(39(29)55)31-12-13-33(52)46-38(31)54/h5-7,16,19,24-27,31,41H,3-4,8-15,17-18,20-23H2,1-2H3,(H,42,51)(H,43,44,45)(H,46,52,54)/t26-,27+,31?","KVMSGNPTEGWHND-DANFTSOSSA-N"
"1715","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)NCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)=NC=NN2C=C1","","","","","","21","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","796.974","796.438429512","3.55","58","7","12","4","16","190.45","C42H56N10O6","InChI=1S/C42H56N10O6/c1-27(2)30-18-21-51-38(30)39(45-26-46-51)47-28-10-12-29(13-11-28)49-22-24-50(25-23-49)36(55)17-16-34(53)44-20-6-4-3-5-19-43-32-9-7-8-31-37(32)42(58)52(41(31)57)33-14-15-35(54)48-40(33)56/h7-9,18,21,26-29,33,43H,3-6,10-17,19-20,22-25H2,1-2H3,(H,44,53)(H,45,46,47)(H,48,54,56)/t28-,29+,33?","QNSXCVHZCXUIBB-ZWEIZTMOSA-N"
"1716","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)N5CCC(CN6CCN(C7=CC=C8C(=O)N(C9CCC(=O)NC9=O)C(=O)C8=C7)CC6)CC5)CC4)CC3)=NC=NN2C=C1","52","74","Degradation of IRAK3 in THP1 cells after 16 h treatment","","","6.3","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","864.065","863.480628672","2.44","63","9","13","2","11","176.11","C46H61N11O6","InChI=1S/C46H61N11O6/c1-30(2)35-15-18-56-42(35)43(47-29-48-56)49-32-3-5-33(6-4-32)52-23-25-55(26-24-52)41(60)12-11-40(59)54-16-13-31(14-17-54)28-51-19-21-53(22-20-51)34-7-8-36-37(27-34)46(63)57(45(36)62)38-9-10-39(58)50-44(38)61/h7-8,15,18,27,29-33,38H,3-6,9-14,16-17,19-26,28H2,1-2H3,(H,47,48,49)(H,50,58,61)/t32-,33+,38?","PVLXFMAKABZOPF-YVLRYLSESA-N"
"1717","Q9Y616","IRAK3","CRBN","","","CC(C)C1=C2C(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)N5CCC(CCN6CCN(C7=CC=C8C(=O)N(C9CCC(=O)NC9=O)C(=O)C8=C7)CC6)CC5)CC4)CC3)=NC=NN2C=C1","2","98","Degradation of IRAK3 in THP1 cells after 16 h treatment","","","4.9","LanthaScreen Eu IRAK3 binding displacement assay using an Alexa Fluor conjugate","","","34","Kd apparent of IRAK3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01125","878.092","877.496278736","2.8","64","9","13","2","12","176.11","C47H63N11O6","InChI=1S/C47H63N11O6/c1-31(2)36-16-20-57-43(36)44(48-30-49-57)50-33-3-5-34(6-4-33)53-25-27-56(28-26-53)42(61)12-11-41(60)55-18-14-32(15-19-55)13-17-52-21-23-54(24-22-52)35-7-8-37-38(29-35)47(64)58(46(37)63)39-9-10-40(59)51-45(39)62/h7-8,16,20,29-34,39H,3-6,9-15,17-19,21-28H2,1-2H3,(H,48,49,50)(H,51,59,62)/t33-,34+,39?","ZUODKONSNNHSAJ-AMLBMYBGSA-N"
"1718","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","935.808","935.21488582","6.33","58","5","10","6","16","174.02","C40H45F3IN7O6S","InChI=1S/C40H45F3IN7O6S/c1-22-35(58-21-47-22)24-8-6-23(7-9-24)18-46-38(55)31-17-26(52)20-51(31)39(56)36(40(2,3)4)49-32(53)19-45-14-5-15-57-50-37(54)27-11-12-28(41)33(43)34(27)48-30-13-10-25(44)16-29(30)42/h6-13,16,21,26,31,36,45,48,52H,5,14-15,17-20H2,1-4H3,(H,46,55)(H,49,53)(H,50,54)/t26-,31+,36-/m1/s1","VAFUQEDSLNNXFH-IWYIWRMPSA-N"
"1718","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","935.808","935.21488582","6.33","58","5","10","6","16","174.02","C40H45F3IN7O6S","InChI=1S/C40H45F3IN7O6S/c1-22-35(58-21-47-22)24-8-6-23(7-9-24)18-46-38(55)31-17-26(52)20-51(31)39(56)36(40(2,3)4)49-32(53)19-45-14-5-15-57-50-37(54)27-11-12-28(41)33(43)34(27)48-30-13-10-25(44)16-29(30)42/h6-13,16,21,26,31,36,45,48,52H,5,14-15,17-20H2,1-4H3,(H,46,55)(H,49,53)(H,50,54)/t26-,31+,36-/m1/s1","VAFUQEDSLNNXFH-IWYIWRMPSA-N"
"1719","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5000","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","949.835","949.230535884","6.24","59","5","10","6","17","174.02","C41H47F3IN7O6S","InChI=1S/C41H47F3IN7O6S/c1-23-36(59-22-48-23)25-8-6-24(7-9-25)20-47-39(56)32-19-27(53)21-52(32)40(57)37(41(2,3)4)50-33(54)14-16-46-15-5-17-58-51-38(55)28-11-12-29(42)34(44)35(28)49-31-13-10-26(45)18-30(31)43/h6-13,18,22,27,32,37,46,49,53H,5,14-17,19-21H2,1-4H3,(H,47,56)(H,50,54)(H,51,55)/t27-,32+,37-/m1/s1","IXOJNHREQPOHJW-WAKPVKDYSA-N"
"1719","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5000","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","949.835","949.230535884","6.24","59","5","10","6","17","174.02","C41H47F3IN7O6S","InChI=1S/C41H47F3IN7O6S/c1-23-36(59-22-48-23)25-8-6-24(7-9-25)20-47-39(56)32-19-27(53)21-52(32)40(57)37(41(2,3)4)50-33(54)14-16-46-15-5-17-58-51-38(55)28-11-12-29(42)34(44)35(28)49-31-13-10-26(45)18-30(31)43/h6-13,18,22,27,32,37,46,49,53H,5,14-17,19-21H2,1-4H3,(H,47,56)(H,50,54)(H,51,55)/t27-,32+,37-/m1/s1","IXOJNHREQPOHJW-WAKPVKDYSA-N"
"1720","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","963.862","963.246185948","6.59","60","5","10","6","18","174.02","C42H49F3IN7O6S","InChI=1S/C42H49F3IN7O6S/c1-24-37(60-23-49-24)26-10-8-25(9-11-26)21-48-40(57)33-20-28(54)22-53(33)41(58)38(42(2,3)4)51-34(55)7-5-16-47-17-6-18-59-52-39(56)29-13-14-30(43)35(45)36(29)50-32-15-12-27(46)19-31(32)44/h8-15,19,23,28,33,38,47,50,54H,5-7,16-18,20-22H2,1-4H3,(H,48,57)(H,51,55)(H,52,56)/t28-,33+,38-/m1/s1","UVUAUFSMHKODMC-ZXHANESPSA-N"
"1720","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","963.862","963.246185948","6.59","60","5","10","6","18","174.02","C42H49F3IN7O6S","InChI=1S/C42H49F3IN7O6S/c1-24-37(60-23-49-24)26-10-8-25(9-11-26)21-48-40(57)33-20-28(54)22-53(33)41(58)38(42(2,3)4)51-34(55)7-5-16-47-17-6-18-59-52-39(56)29-13-14-30(43)35(45)36(29)50-32-15-12-27(46)19-31(32)44/h8-15,19,23,28,33,38,47,50,54H,5-7,16-18,20-22H2,1-4H3,(H,48,57)(H,51,55)(H,52,56)/t28-,33+,38-/m1/s1","UVUAUFSMHKODMC-ZXHANESPSA-N"
"1721","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3000","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","977.889","977.261836012","6.95","61","5","10","6","19","174.02","C43H51F3IN7O6S","InChI=1S/C43H51F3IN7O6S/c1-25-38(61-24-50-25)27-11-9-26(10-12-27)22-49-41(58)34-21-29(55)23-54(34)42(59)39(43(2,3)4)52-35(56)8-5-6-17-48-18-7-19-60-53-40(57)30-14-15-31(44)36(46)37(30)51-33-16-13-28(47)20-32(33)45/h9-16,20,24,29,34,39,48,51,55H,5-8,17-19,21-23H2,1-4H3,(H,49,58)(H,52,56)(H,53,57)/t29-,34+,39-/m1/s1","OHNDPHUIDAWOKL-MTAGQQIASA-N"
"1721","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3000","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","977.889","977.261836012","6.95","61","5","10","6","19","174.02","C43H51F3IN7O6S","InChI=1S/C43H51F3IN7O6S/c1-25-38(61-24-50-25)27-11-9-26(10-12-27)22-49-41(58)34-21-29(55)23-54(34)42(59)39(43(2,3)4)52-35(56)8-5-6-17-48-18-7-19-60-53-40(57)30-14-15-31(44)36(46)37(30)51-33-16-13-28(47)20-32(33)45/h9-16,20,24,29,34,39,48,51,55H,5-8,17-19,21-23H2,1-4H3,(H,49,58)(H,52,56)(H,53,57)/t29-,34+,39-/m1/s1","OHNDPHUIDAWOKL-MTAGQQIASA-N"
"1722","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","991.916","991.277486076","7.31","62","5","10","6","20","174.02","C44H53F3IN7O6S","InChI=1S/C44H53F3IN7O6S/c1-26-39(62-25-51-26)28-12-10-27(11-13-28)23-50-42(59)35-22-30(56)24-55(35)43(60)40(44(2,3)4)53-36(57)9-6-5-7-18-49-19-8-20-61-54-41(58)31-15-16-32(45)37(47)38(31)52-34-17-14-29(48)21-33(34)46/h10-17,21,25,30,35,40,49,52,56H,5-9,18-20,22-24H2,1-4H3,(H,50,59)(H,53,57)(H,54,58)/t30-,35+,40-/m1/s1","WIVRCFRBDBRSLQ-LMKVZTAHSA-N"
"1722","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","991.916","991.277486076","7.31","62","5","10","6","20","174.02","C44H53F3IN7O6S","InChI=1S/C44H53F3IN7O6S/c1-26-39(62-25-51-26)28-12-10-27(11-13-28)23-50-42(59)35-22-30(56)24-55(35)43(60)40(44(2,3)4)53-36(57)9-6-5-7-18-49-19-8-20-61-54-41(58)31-15-16-32(45)37(47)38(31)52-34-17-14-29(48)21-33(34)46/h10-17,21,25,30,35,40,49,52,56H,5-9,18-20,22-24H2,1-4H3,(H,50,59)(H,53,57)(H,54,58)/t30-,35+,40-/m1/s1","WIVRCFRBDBRSLQ-LMKVZTAHSA-N"
"1723","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1019.97","1019.3087862","8.39","64","5","10","6","22","174.02","C46H57F3IN7O6S","InChI=1S/C46H57F3IN7O6S/c1-28-41(64-27-53-28)30-14-12-29(13-15-30)25-52-44(61)37-24-32(58)26-57(37)45(62)42(46(2,3)4)55-38(59)11-8-6-5-7-9-20-51-21-10-22-63-56-43(60)33-17-18-34(47)39(49)40(33)54-36-19-16-31(50)23-35(36)48/h12-19,23,27,32,37,42,51,54,58H,5-11,20-22,24-26H2,1-4H3,(H,52,61)(H,55,59)(H,56,60)/t32-,37+,42-/m1/s1","QQHRBAFJHPQTSL-DDMJSYEZSA-N"
"1723","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1019.97","1019.3087862","8.39","64","5","10","6","22","174.02","C46H57F3IN7O6S","InChI=1S/C46H57F3IN7O6S/c1-28-41(64-27-53-28)30-14-12-29(13-15-30)25-52-44(61)37-24-32(58)26-57(37)45(62)42(46(2,3)4)55-38(59)11-8-6-5-7-9-20-51-21-10-22-63-56-43(60)33-17-18-34(47)39(49)40(33)54-36-19-16-31(50)23-35(36)48/h12-19,23,27,32,37,42,51,54,58H,5-11,20-22,24-26H2,1-4H3,(H,52,61)(H,55,59)(H,56,60)/t32-,37+,42-/m1/s1","QQHRBAFJHPQTSL-DDMJSYEZSA-N"
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"1725","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1048.024","1047.34008633","9.47","66","5","10","6","24","174.02","C48H61F3IN7O6S","InChI=1S/C48H61F3IN7O6S/c1-30-43(66-29-55-30)32-16-14-31(15-17-32)27-54-46(63)39-26-34(60)28-59(39)47(64)44(48(2,3)4)57-40(61)13-10-8-6-5-7-9-11-22-53-23-12-24-65-58-45(62)35-19-20-36(49)41(51)42(35)56-38-21-18-33(52)25-37(38)50/h14-21,25,29,34,39,44,53,56,60H,5-13,22-24,26-28H2,1-4H3,(H,54,63)(H,57,61)(H,58,62)/t34-,39+,44-/m1/s1","QYHUXMHVDIGTRN-SVJXQAPASA-N"
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"1726","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4000","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","979.861","979.241100568","6.18","61","5","11","6","19","183.25","C42H49F3IN7O7S","InChI=1S/C42H49F3IN7O7S/c1-24-37(61-23-49-24)26-8-6-25(7-9-26)20-48-40(57)33-19-28(54)21-53(33)41(58)38(42(2,3)4)51-34(55)22-59-17-15-47-14-5-16-60-52-39(56)29-11-12-30(43)35(45)36(29)50-32-13-10-27(46)18-31(32)44/h6-13,18,23,28,33,38,47,50,54H,5,14-17,19-22H2,1-4H3,(H,48,57)(H,51,55)(H,52,56)/t28-,33+,38-/m1/s1","XYXFEXLHGFVNSN-ZXHANESPSA-N"
"1727","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","993.888","993.256750632","6.09","62","5","11","6","20","183.25","C43H51F3IN7O7S","InChI=1S/C43H51F3IN7O7S/c1-25-38(62-24-50-25)27-8-6-26(7-9-27)22-49-41(58)34-21-29(55)23-54(34)42(59)39(43(2,3)4)52-35(56)14-18-60-19-16-48-15-5-17-61-53-40(57)30-11-12-31(44)36(46)37(30)51-33-13-10-28(47)20-32(33)45/h6-13,20,24,29,34,39,48,51,55H,5,14-19,21-23H2,1-4H3,(H,49,58)(H,52,56)(H,53,57)/t29-,34+,39-/m1/s1","KDOCRWQSKXDVBF-MTAGQQIASA-N"
"1727","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","993.888","993.256750632","6.09","62","5","11","6","20","183.25","C43H51F3IN7O7S","InChI=1S/C43H51F3IN7O7S/c1-25-38(62-24-50-25)27-8-6-26(7-9-27)22-49-41(58)34-21-29(55)23-54(34)42(59)39(43(2,3)4)52-35(56)14-18-60-19-16-48-15-5-17-61-53-40(57)30-11-12-31(44)36(46)37(30)51-33-13-10-28(47)20-32(33)45/h6-13,20,24,29,34,39,48,51,55H,5,14-19,21-23H2,1-4H3,(H,49,58)(H,52,56)(H,53,57)/t29-,34+,39-/m1/s1","KDOCRWQSKXDVBF-MTAGQQIASA-N"
"1728","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1600","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1023.914","1023.26731532","6.04","64","5","12","6","22","192.48","C44H53F3IN7O8S","InChI=1S/C44H53F3IN7O8S/c1-26-39(64-25-51-26)28-8-6-27(7-9-28)22-50-42(59)35-21-30(56)23-55(35)43(60)40(44(2,3)4)53-36(57)24-62-19-18-61-17-15-49-14-5-16-63-54-41(58)31-11-12-32(45)37(47)38(31)52-34-13-10-29(48)20-33(34)46/h6-13,20,25,30,35,40,49,52,56H,5,14-19,21-24H2,1-4H3,(H,50,59)(H,53,57)(H,54,58)/t30-,35+,40-/m1/s1","CRNDTESOFYODGS-LMKVZTAHSA-N"
"1728","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1600","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1023.914","1023.26731532","6.04","64","5","12","6","22","192.48","C44H53F3IN7O8S","InChI=1S/C44H53F3IN7O8S/c1-26-39(64-25-51-26)28-8-6-27(7-9-28)22-50-42(59)35-21-30(56)23-55(35)43(60)40(44(2,3)4)53-36(57)24-62-19-18-61-17-15-49-14-5-16-63-54-41(58)31-11-12-32(45)37(47)38(31)52-34-13-10-29(48)20-33(34)46/h6-13,20,25,30,35,40,49,52,56H,5,14-19,21-24H2,1-4H3,(H,50,59)(H,53,57)(H,54,58)/t30-,35+,40-/m1/s1","CRNDTESOFYODGS-LMKVZTAHSA-N"
"1729","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1600","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1037.941","1037.28296538","5.94","65","5","12","6","23","192.48","C45H55F3IN7O8S","InChI=1S/C45H55F3IN7O8S/c1-27-40(65-26-52-27)29-8-6-28(7-9-29)24-51-43(60)36-23-31(57)25-56(36)44(61)41(45(2,3)4)54-37(58)14-18-62-20-21-63-19-16-50-15-5-17-64-55-42(59)32-11-12-33(46)38(48)39(32)53-35-13-10-30(49)22-34(35)47/h6-13,22,26,31,36,41,50,53,57H,5,14-21,23-25H2,1-4H3,(H,51,60)(H,54,58)(H,55,59)/t31-,36+,41-/m1/s1","CHPPTNJZJOJKPI-KSEFXOEKSA-N"
"1729","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1600","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1037.941","1037.28296538","5.94","65","5","12","6","23","192.48","C45H55F3IN7O8S","InChI=1S/C45H55F3IN7O8S/c1-27-40(65-26-52-27)29-8-6-28(7-9-29)24-51-43(60)36-23-31(57)25-56(36)44(61)41(45(2,3)4)54-37(58)14-18-62-20-21-63-19-16-50-15-5-17-64-55-42(59)32-11-12-33(46)38(48)39(32)53-35-13-10-30(49)22-34(35)47/h6-13,22,26,31,36,41,50,53,57H,5,14-21,23-25H2,1-4H3,(H,51,60)(H,54,58)(H,55,59)/t31-,36+,41-/m1/s1","CHPPTNJZJOJKPI-KSEFXOEKSA-N"
"1730","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3300","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1081.994","1081.30918013","5.79","68","5","13","6","26","201.71","C47H59F3IN7O9S","InChI=1S/C47H59F3IN7O9S/c1-29-42(68-28-54-29)31-8-6-30(7-9-31)26-53-45(62)38-25-33(59)27-58(38)46(63)43(47(2,3)4)56-39(60)14-18-64-20-22-66-23-21-65-19-16-52-15-5-17-67-57-44(61)34-11-12-35(48)40(50)41(34)55-37-13-10-32(51)24-36(37)49/h6-13,24,28,33,38,43,52,55,59H,5,14-23,25-27H2,1-4H3,(H,53,62)(H,56,60)(H,57,61)/t33-,38+,43-/m1/s1","KNWJCHOPRHPEQX-TZSMONEZSA-N"
"1730","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3300","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1081.994","1081.30918013","5.79","68","5","13","6","26","201.71","C47H59F3IN7O9S","InChI=1S/C47H59F3IN7O9S/c1-29-42(68-28-54-29)31-8-6-30(7-9-31)26-53-45(62)38-25-33(59)27-58(38)46(63)43(47(2,3)4)56-39(60)14-18-64-20-22-66-23-21-65-19-16-52-15-5-17-67-57-44(61)34-11-12-35(48)40(50)41(34)55-37-13-10-32(51)24-36(37)49/h6-13,24,28,33,38,43,52,55,59H,5,14-23,25-27H2,1-4H3,(H,53,62)(H,56,60)(H,57,61)/t33-,38+,43-/m1/s1","KNWJCHOPRHPEQX-TZSMONEZSA-N"
"1731","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1700","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1126.047","1125.33539488","5.64","71","5","14","6","29","210.94","C49H63F3IN7O10S","InChI=1S/C49H63F3IN7O10S/c1-31-44(71-30-56-31)33-8-6-32(7-9-33)28-55-47(64)40-27-35(61)29-60(40)48(65)45(49(2,3)4)58-41(62)14-18-66-20-22-68-24-25-69-23-21-67-19-16-54-15-5-17-70-59-46(63)36-11-12-37(50)42(52)43(36)57-39-13-10-34(53)26-38(39)51/h6-13,26,30,35,40,45,54,57,61H,5,14-25,27-29H2,1-4H3,(H,55,64)(H,58,62)(H,59,63)/t35-,40+,45-/m1/s1","YJQIIACMVVCZCD-RIXQQIMYSA-N"
"1731","P36507","MEK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1700","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1126.047","1125.33539488","5.64","71","5","14","6","29","210.94","C49H63F3IN7O10S","InChI=1S/C49H63F3IN7O10S/c1-31-44(71-30-56-31)33-8-6-32(7-9-33)28-55-47(64)40-27-35(61)29-60(40)48(65)45(49(2,3)4)58-41(62)14-18-66-20-22-68-24-25-69-23-21-67-19-16-54-15-5-17-70-59-46(63)36-11-12-37(50)42(52)43(36)57-39-13-10-34(53)26-38(39)51/h6-13,26,30,35,40,45,54,57,61H,5,14-25,27-29H2,1-4H3,(H,55,64)(H,58,62)(H,59,63)/t35-,40+,45-/m1/s1","YJQIIACMVVCZCD-RIXQQIMYSA-N"
"1732","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","240","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1062.051","1061.3557364","9.87","67","5","10","6","24","174.02","C49H63F3IN7O6S","InChI=1S/C49H63F3IN7O6S/c1-30(32-15-17-33(18-16-32)44-31(2)55-29-67-44)56-47(64)40-27-35(61)28-60(40)48(65)45(49(3,4)5)58-41(62)14-11-9-7-6-8-10-12-23-54-24-13-25-66-59-46(63)36-20-21-37(50)42(52)43(36)57-39-22-19-34(53)26-38(39)51/h15-22,26,29-30,35,40,45,54,57,61H,6-14,23-25,27-28H2,1-5H3,(H,56,64)(H,58,62)(H,59,63)/t30-,35+,40-,45+/m0/s1","HFHKWFVACYSURQ-ALNHQPHUSA-N"
"1732","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","240","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1062.051","1061.3557364","9.87","67","5","10","6","24","174.02","C49H63F3IN7O6S","InChI=1S/C49H63F3IN7O6S/c1-30(32-15-17-33(18-16-32)44-31(2)55-29-67-44)56-47(64)40-27-35(61)28-60(40)48(65)45(49(3,4)5)58-41(62)14-11-9-7-6-8-10-12-23-54-24-13-25-66-59-46(63)36-20-21-37(50)42(52)43(36)57-39-22-19-34(53)26-38(39)51/h15-22,26,29-30,35,40,45,54,57,61H,6-14,23-25,27-28H2,1-5H3,(H,56,64)(H,58,62)(H,59,63)/t30-,35+,40-,45+/m0/s1","HFHKWFVACYSURQ-ALNHQPHUSA-N"
"1733","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","99","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.96","69","5","10","6","26","174.02","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)57-31-69-46)58-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)60-43(64)16-13-11-9-7-6-8-10-12-14-25-56-26-15-27-68-61-48(65)38-22-23-39(52)44(54)45(38)59-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,56,59,63H,6-16,25-27,29-30H2,1-5H3,(H,58,66)(H,60,64)(H,61,65)/t32-,37+,42-,47+/m0/s1","NDGCJOXPPUMBSE-IJSQUPEFSA-N"
"1733","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","99","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.96","69","5","10","6","26","174.02","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)57-31-69-46)58-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)60-43(64)16-13-11-9-7-6-8-10-12-14-25-56-26-15-27-68-61-48(65)38-22-23-39(52)44(54)45(38)59-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,56,59,63H,6-16,25-27,29-30H2,1-5H3,(H,58,66)(H,60,64)(H,61,65)/t32-,37+,42-,47+/m0/s1","NDGCJOXPPUMBSE-IJSQUPEFSA-N"
"1734","P36507","MEK2","VHL","","MS928","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCN(C)CCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","8/6","","Degradation of MEK2 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","1400","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32/56/360","Inhibit proliferation of HT-29/SK-MEL-28/SUDHL1 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.88","69","5","10","5","25","165.23","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)56-31-69-46)57-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)59-43(64)16-13-11-9-7-8-10-12-14-25-61(6)26-15-27-68-60-48(65)38-22-23-39(52)44(54)45(38)58-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,58,63H,7-16,25-27,29-30H2,1-6H3,(H,57,66)(H,59,64)(H,60,65)/t32-,37+,42-,47+/m0/s1","DXMOVGRUXPNRRX-IJSQUPEFSA-N"
"1734","Q02750","MEK1","VHL","","MS928","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCN(C)CCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","18/16","","Degradation of MEK1 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","400","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32/56/360","Inhibit proliferation of HT-29/SK-MEL-28/SUDHL1 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.88","69","5","10","5","25","165.23","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)56-31-69-46)57-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)59-43(64)16-13-11-9-7-8-10-12-14-25-61(6)26-15-27-68-60-48(65)38-22-23-39(52)44(54)45(38)58-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,58,63H,7-16,25-27,29-30H2,1-6H3,(H,57,66)(H,59,64)(H,60,65)/t32-,37+,42-,47+/m0/s1","DXMOVGRUXPNRRX-IJSQUPEFSA-N"
"1735","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","55","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1076.078","1075.37138646","10.23","68","5","10","6","25","174.02","C50H65F3IN7O6S","InChI=1S/C50H65F3IN7O6S/c1-31(33-16-18-34(19-17-33)45-32(2)56-30-68-45)57-48(65)41-28-36(62)29-61(41)49(66)46(50(3,4)5)59-42(63)15-11-9-7-6-8-10-12-24-55-25-13-14-26-67-60-47(64)37-21-22-38(51)43(53)44(37)58-40-23-20-35(54)27-39(40)52/h16-23,27,30-31,36,41,46,55,58,62H,6-15,24-26,28-29H2,1-5H3,(H,57,65)(H,59,63)(H,60,64)/t31-,36+,41-,46+/m0/s1","KIGICGZPLSFUKD-BSZYMOERSA-N"
"1735","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","55","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1076.078","1075.37138646","10.23","68","5","10","6","25","174.02","C50H65F3IN7O6S","InChI=1S/C50H65F3IN7O6S/c1-31(33-16-18-34(19-17-33)45-32(2)56-30-68-45)57-48(65)41-28-36(62)29-61(41)49(66)46(50(3,4)5)59-42(63)15-11-9-7-6-8-10-12-24-55-25-13-14-26-67-60-47(64)37-21-22-38(51)43(53)44(37)58-40-23-20-35(54)27-39(40)52/h16-23,27,30-31,36,41,46,55,58,62H,6-15,24-26,28-29H2,1-5H3,(H,57,65)(H,59,63)(H,60,64)/t31-,36+,41-,46+/m0/s1","KIGICGZPLSFUKD-BSZYMOERSA-N"
"1736","Q02750","MEK1","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.77","69","5","10","6","26","174.02","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)57-31-69-46)58-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)60-43(64)16-12-10-8-6-7-9-11-13-25-56-26-14-15-27-68-61-48(65)38-22-23-39(52)44(54)45(38)59-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,56,59,63H,6-16,25-27,29-30H2,1-5H3,(H,58,66)(H,60,64)(H,61,65)/t32-,37+,42-,47+/m0/s1","ANWAQLVYRKSECQ-IJSQUPEFSA-N"
"1736","P36507","MEK2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1090.105","1089.38703652","10.77","69","5","10","6","26","174.02","C51H67F3IN7O6S","InChI=1S/C51H67F3IN7O6S/c1-32(34-17-19-35(20-18-34)46-33(2)57-31-69-46)58-49(66)42-29-37(63)30-62(42)50(67)47(51(3,4)5)60-43(64)16-12-10-8-6-7-9-11-13-25-56-26-14-15-27-68-61-48(65)38-22-23-39(52)44(54)45(38)59-41-24-21-36(55)28-40(41)53/h17-24,28,31-32,37,42,47,56,59,63H,6-16,25-27,29-30H2,1-5H3,(H,58,66)(H,60,64)(H,61,65)/t32-,37+,42-,47+/m0/s1","ANWAQLVYRKSECQ-IJSQUPEFSA-N"
"1737","P36507","MEK2","VHL","","MS934","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","9/4","","Degradation of MEK2 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","2000","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","23/40/330","Inhibit proliferation of HT-29/SK-MEL-28/SUDHL1 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1104.132","1103.40268659","11.31","70","5","10","6","27","174.02","C52H69F3IN7O6S","InChI=1S/C52H69F3IN7O6S/c1-33(35-18-20-36(21-19-35)47-34(2)58-32-70-47)59-50(67)43-30-38(64)31-63(43)51(68)48(52(3,4)5)61-44(65)17-13-11-9-7-6-8-10-12-14-26-57-27-15-16-28-69-62-49(66)39-23-24-40(53)45(55)46(39)60-42-25-22-37(56)29-41(42)54/h18-25,29,32-33,38,43,48,57,60,64H,6-17,26-28,30-31H2,1-5H3,(H,59,67)(H,61,65)(H,62,66)/t33-,38+,43-,48+/m0/s1","DYLGPTDXXUWFMK-ARFQKLFXSA-N"
"1737","Q02750","MEK1","VHL","","MS934","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCNCCCCONC(=O)C3=CC=C(F)C(F)=C3NC3=CC=C(I)C=C3F)C(C)(C)C)C=C2)SC=N1","18/10","","Degradation of MEK1 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","400","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","23/40/330","Inhibit proliferation of HT-29/SK-MEL-28/SUDHL1 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","1104.132","1103.40268659","11.31","70","5","10","6","27","174.02","C52H69F3IN7O6S","InChI=1S/C52H69F3IN7O6S/c1-33(35-18-20-36(21-19-35)47-34(2)58-32-70-47)59-50(67)43-30-38(64)31-63(43)51(68)48(52(3,4)5)61-44(65)17-13-11-9-7-6-8-10-12-14-26-57-27-15-16-28-69-62-49(66)39-23-24-40(53)45(55)46(39)60-42-25-22-37(56)29-41(42)54/h18-25,29,32-33,38,43,48,57,60,64H,6-17,26-28,30-31H2,1-5H3,(H,59,67)(H,61,65)(H,62,66)/t33-,38+,43-,48+/m0/s1","DYLGPTDXXUWFMK-ARFQKLFXSA-N"
"1738","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","778.526","778.12236534","5.01","48","5","9","5","14","157.97","C32H30F3IN6O6","InChI=1S/C32H30F3IN6O6/c33-20-8-7-19(28(27(20)35)39-22-9-6-17(36)16-21(22)34)29(44)41-48-15-3-13-37-12-2-14-38-23-5-1-4-18-26(23)32(47)42(31(18)46)24-10-11-25(43)40-30(24)45/h1,4-9,16,24,37-39H,2-3,10-15H2,(H,41,44)(H,40,43,45)","IDWNHWLTKUAOPL-UHFFFAOYSA-N"
"1738","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","778.526","778.12236534","5.01","48","5","9","5","14","157.97","C32H30F3IN6O6","InChI=1S/C32H30F3IN6O6/c33-20-8-7-19(28(27(20)35)39-22-9-6-17(36)16-21(22)34)29(44)41-48-15-3-13-37-12-2-14-38-23-5-1-4-18-26(23)32(47)42(31(18)46)24-10-11-25(43)40-30(24)45/h1,4-9,16,24,37-39H,2-3,10-15H2,(H,41,44)(H,40,43,45)","IDWNHWLTKUAOPL-UHFFFAOYSA-N"
"1739","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1900","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","792.553","792.138015404","5.37","49","5","9","5","15","157.97","C33H32F3IN6O6","InChI=1S/C33H32F3IN6O6/c34-21-9-8-20(29(28(21)36)40-23-10-7-18(37)17-22(23)35)30(45)42-49-16-4-14-38-13-1-2-15-39-24-6-3-5-19-27(24)33(48)43(32(19)47)25-11-12-26(44)41-31(25)46/h3,5-10,17,25,38-40H,1-2,4,11-16H2,(H,42,45)(H,41,44,46)","DDHBKUPAQGUHKF-UHFFFAOYSA-N"
"1739","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1900","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","792.553","792.138015404","5.37","49","5","9","5","15","157.97","C33H32F3IN6O6","InChI=1S/C33H32F3IN6O6/c34-21-9-8-20(29(28(21)36)40-23-10-7-18(37)17-22(23)35)30(45)42-49-16-4-14-38-13-1-2-15-39-24-6-3-5-19-27(24)33(48)43(32(19)47)25-11-12-26(44)41-31(25)46/h3,5-10,17,25,38-40H,1-2,4,11-16H2,(H,42,45)(H,41,44,46)","DDHBKUPAQGUHKF-UHFFFAOYSA-N"
"1740","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","806.58","806.153665468","5.72","50","5","9","5","16","157.97","C34H34F3IN6O6","InChI=1S/C34H34F3IN6O6/c35-22-10-9-21(30(29(22)37)41-24-11-8-19(38)18-23(24)36)31(46)43-50-17-5-15-39-14-2-1-3-16-40-25-7-4-6-20-28(25)34(49)44(33(20)48)26-12-13-27(45)42-32(26)47/h4,6-11,18,26,39-41H,1-3,5,12-17H2,(H,43,46)(H,42,45,47)","IUCUJNPGHKEFJR-UHFFFAOYSA-N"
"1740","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","806.58","806.153665468","5.72","50","5","9","5","16","157.97","C34H34F3IN6O6","InChI=1S/C34H34F3IN6O6/c35-22-10-9-21(30(29(22)37)41-24-11-8-19(38)18-23(24)36)31(46)43-50-17-5-15-39-14-2-1-3-16-40-25-7-4-6-20-28(25)34(49)44(33(20)48)26-12-13-27(45)42-32(26)47/h4,6-11,18,26,39-41H,1-3,5,12-17H2,(H,43,46)(H,42,45,47)","IUCUJNPGHKEFJR-UHFFFAOYSA-N"
"1741","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","820.607","820.169315532","6.08","51","5","9","5","17","157.97","C35H36F3IN6O6","InChI=1S/C35H36F3IN6O6/c36-23-11-10-22(31(30(23)38)42-25-12-9-20(39)19-24(25)37)32(47)44-51-18-6-16-40-15-3-1-2-4-17-41-26-8-5-7-21-29(26)35(50)45(34(21)49)27-13-14-28(46)43-33(27)48/h5,7-12,19,27,40-42H,1-4,6,13-18H2,(H,44,47)(H,43,46,48)","YFVGVGBOBWUSEB-UHFFFAOYSA-N"
"1741","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3800","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","820.607","820.169315532","6.08","51","5","9","5","17","157.97","C35H36F3IN6O6","InChI=1S/C35H36F3IN6O6/c36-23-11-10-22(31(30(23)38)42-25-12-9-20(39)19-24(25)37)32(47)44-51-18-6-16-40-15-3-1-2-4-17-41-26-8-5-7-21-29(26)35(50)45(34(21)49)27-13-14-28(46)43-33(27)48/h5,7-12,19,27,40-42H,1-4,6,13-18H2,(H,44,47)(H,43,46,48)","YFVGVGBOBWUSEB-UHFFFAOYSA-N"
"1742","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","834.634","834.184965596","6.62","52","5","9","5","18","157.97","C36H38F3IN6O6","InChI=1S/C36H38F3IN6O6/c37-24-12-11-23(32(31(24)39)43-26-13-10-21(40)20-25(26)38)33(48)45-52-19-7-17-41-16-4-2-1-3-5-18-42-27-9-6-8-22-30(27)36(51)46(35(22)50)28-14-15-29(47)44-34(28)49/h6,8-13,20,28,41-43H,1-5,7,14-19H2,(H,45,48)(H,44,47,49)","ITTKTYPKRSJYTR-UHFFFAOYSA-N"
"1742","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","834.634","834.184965596","6.62","52","5","9","5","18","157.97","C36H38F3IN6O6","InChI=1S/C36H38F3IN6O6/c37-24-12-11-23(32(31(24)39)43-26-13-10-21(40)20-25(26)38)33(48)45-52-19-7-17-41-16-4-2-1-3-5-18-42-27-9-6-8-22-30(27)36(51)46(35(22)50)28-14-15-29(47)44-34(28)49/h6,8-13,20,28,41-43H,1-5,7,14-19H2,(H,45,48)(H,44,47,49)","ITTKTYPKRSJYTR-UHFFFAOYSA-N"
"1743","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","848.661","848.20061566","7.16","53","5","9","5","19","157.97","C37H40F3IN6O6","InChI=1S/C37H40F3IN6O6/c38-25-13-12-24(33(32(25)40)44-27-14-11-22(41)21-26(27)39)34(49)46-53-20-8-18-42-17-5-3-1-2-4-6-19-43-28-10-7-9-23-31(28)37(52)47(36(23)51)29-15-16-30(48)45-35(29)50/h7,9-14,21,29,42-44H,1-6,8,15-20H2,(H,46,49)(H,45,48,50)","YZCXHPKWIKVFHK-UHFFFAOYSA-N"
"1743","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","848.661","848.20061566","7.16","53","5","9","5","19","157.97","C37H40F3IN6O6","InChI=1S/C37H40F3IN6O6/c38-25-13-12-24(33(32(25)40)44-27-14-11-22(41)21-26(27)39)34(49)46-53-20-8-18-42-17-5-3-1-2-4-6-19-43-28-10-7-9-23-31(28)37(52)47(36(23)51)29-15-16-30(48)45-35(29)50/h7,9-14,21,29,42-44H,1-6,8,15-20H2,(H,46,49)(H,45,48,50)","YZCXHPKWIKVFHK-UHFFFAOYSA-N"
"1744","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1300","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","852.605","852.159144772","4.36","53","5","11","5","19","176.43","C35H36F3IN6O8","InChI=1S/C35H36F3IN6O8/c36-23-7-6-22(31(30(23)38)42-25-8-5-20(39)19-24(25)37)32(47)44-53-14-2-11-40-12-15-51-17-18-52-16-13-41-26-4-1-3-21-29(26)35(50)45(34(21)49)27-9-10-28(46)43-33(27)48/h1,3-8,19,27,40-42H,2,9-18H2,(H,44,47)(H,43,46,48)","SMECJDLOVVUSGP-UHFFFAOYSA-N"
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"1754","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1400","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","808.552","808.132930024","3.95","50","5","10","5","16","167.2","C33H32F3IN6O7","InChI=1S/C33H32F3IN6O7/c34-23-6-5-21(29(28(23)36)40-25-7-2-18(37)16-24(25)35)30(45)42-50-13-1-10-38-11-14-49-15-12-39-19-3-4-20-22(17-19)33(48)43(32(20)47)26-8-9-27(44)41-31(26)46/h2-7,16-17,26,38-40H,1,8-15H2,(H,42,45)(H,41,44,46)","MKOMPERCEWICCM-UHFFFAOYSA-N"
"1754","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1400","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","808.552","808.132930024","3.95","50","5","10","5","16","167.2","C33H32F3IN6O7","InChI=1S/C33H32F3IN6O7/c34-23-6-5-21(29(28(23)36)40-25-7-2-18(37)16-24(25)35)30(45)42-50-13-1-10-38-11-14-49-15-12-39-19-3-4-20-22(17-19)33(48)43(32(20)47)26-8-9-27(44)41-31(26)46/h2-7,16-17,26,38-40H,1,8-15H2,(H,42,45)(H,41,44,46)","MKOMPERCEWICCM-UHFFFAOYSA-N"
"1755","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","852.605","852.159144772","3.81","53","5","11","5","19","176.43","C35H36F3IN6O8","InChI=1S/C35H36F3IN6O8/c36-25-6-5-23(31(30(25)38)42-27-7-2-20(39)18-26(27)37)32(47)44-53-13-1-10-40-11-14-51-16-17-52-15-12-41-21-3-4-22-24(19-21)35(50)45(34(22)49)28-8-9-29(46)43-33(28)48/h2-7,18-19,28,40-42H,1,8-17H2,(H,44,47)(H,43,46,48)","CABLZPWQJLNUNN-UHFFFAOYSA-N"
"1755","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","852.605","852.159144772","3.81","53","5","11","5","19","176.43","C35H36F3IN6O8","InChI=1S/C35H36F3IN6O8/c36-25-6-5-23(31(30(25)38)42-27-7-2-20(39)18-26(27)37)32(47)44-53-13-1-10-40-11-14-51-16-17-52-15-12-41-21-3-4-22-24(19-21)35(50)45(34(22)49)28-8-9-29(46)43-33(28)48/h2-7,18-19,28,40-42H,1,8-17H2,(H,44,47)(H,43,46,48)","CABLZPWQJLNUNN-UHFFFAOYSA-N"
"1756","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","896.658","896.18535952","3.66","56","5","12","5","22","185.66","C37H40F3IN6O9","InChI=1S/C37H40F3IN6O9/c38-27-6-5-25(33(32(27)40)44-29-7-2-22(41)20-28(29)39)34(49)46-56-13-1-10-42-11-14-53-16-18-55-19-17-54-15-12-43-23-3-4-24-26(21-23)37(52)47(36(24)51)30-8-9-31(48)45-35(30)50/h2-7,20-21,30,42-44H,1,8-19H2,(H,46,49)(H,45,48,50)","GBNYVIBYTUNUHG-UHFFFAOYSA-N"
"1756","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","896.658","896.18535952","3.66","56","5","12","5","22","185.66","C37H40F3IN6O9","InChI=1S/C37H40F3IN6O9/c38-27-6-5-25(33(32(27)40)44-29-7-2-22(41)20-28(29)39)34(49)46-56-13-1-10-42-11-14-53-16-18-55-19-17-54-15-12-43-23-3-4-24-26(21-23)37(52)47(36(24)51)30-8-9-31(48)45-35(30)50/h2-7,20-21,30,42-44H,1,8-19H2,(H,46,49)(H,45,48,50)","GBNYVIBYTUNUHG-UHFFFAOYSA-N"
"1757","Q02750","MEK1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","940.711","940.211574268","3.51","59","5","13","5","25","194.89","C39H44F3IN6O10","InChI=1S/C39H44F3IN6O10/c40-29-6-5-27(35(34(29)42)46-31-7-2-24(43)22-30(31)41)36(51)48-59-13-1-10-44-11-14-55-16-18-57-20-21-58-19-17-56-15-12-45-25-3-4-26-28(23-25)39(54)49(38(26)53)32-8-9-33(50)47-37(32)52/h2-7,22-23,32,44-46H,1,8-21H2,(H,48,51)(H,47,50,52)","NDVKGLATBKSGPC-UHFFFAOYSA-N"
"1757","P36507","MEK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","500","Inhibit proliferation of HT-29 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","940.711","940.211574268","3.51","59","5","13","5","25","194.89","C39H44F3IN6O10","InChI=1S/C39H44F3IN6O10/c40-29-6-5-27(35(34(29)42)46-31-7-2-24(43)22-30(31)41)36(51)48-59-13-1-10-44-11-14-55-16-18-57-20-21-58-19-17-56-15-12-45-25-3-4-26-28(23-25)39(54)49(38(26)53)32-8-9-33(50)47-37(32)52/h2-7,22-23,32,44-46H,1,8-21H2,(H,48,51)(H,47,50,52)","NDVKGLATBKSGPC-UHFFFAOYSA-N"
"1758","P36507","MEK2","CRBN","","MS910","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","55/38","","Degradation of MEK2 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","2400","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","300/780","Inhibit proliferation of HT-29/SK-MEL-28 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","984.764","984.237789016","3.36","62","5","14","5","28","204.12","C41H48F3IN6O11","InChI=1S/C41H48F3IN6O11/c42-31-6-5-29(37(36(31)44)48-33-7-2-26(45)24-32(33)43)38(53)50-62-13-1-10-46-11-14-57-16-18-59-20-22-61-23-21-60-19-17-58-15-12-47-27-3-4-28-30(25-27)41(56)51(40(28)55)34-8-9-35(52)49-39(34)54/h2-7,24-25,34,46-48H,1,8-23H2,(H,50,53)(H,49,52,54)","OWWBODSADLTRAR-UHFFFAOYSA-N"
"1758","Q02750","MEK1","CRBN","","MS910","O=C1CCC(N2C(=O)C3=CC=C(NCCOCCOCCOCCOCCOCCNCCCONC(=O)C4=CC=C(F)C(F)=C4NC4=CC=C(I)C=C4F)C=C3C2=O)C(=O)N1","118/94","","Degradation of MEK1 in HT-29/SK-MEL-28 cells after 24 h treatment","","","","","","","660","Kd was assessed using the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","300/780","Inhibit proliferation of HT-29/SK-MEL-28 cells","","","","","","","","","","","10.1021/acs.jmedchem.0c01609","984.764","984.237789016","3.36","62","5","14","5","28","204.12","C41H48F3IN6O11","InChI=1S/C41H48F3IN6O11/c42-31-6-5-29(37(36(31)44)48-33-7-2-26(45)24-32(33)43)38(53)50-62-13-1-10-46-11-14-57-16-18-59-20-22-61-23-21-60-19-17-58-15-12-47-27-3-4-28-30(25-27)41(56)51(40(28)55)34-8-9-35(52)49-39(34)54/h2-7,24-25,34,46-48H,1,8-23H2,(H,50,53)(H,49,52,54)","OWWBODSADLTRAR-UHFFFAOYSA-N"
"1759","Q15910","EZH2","CRBN","","","CC[C@H](C)N1C=C(C)C2=C(C(=O)NCC3=C(C)C=C(C)[NH]C3=O)C=C(C3=CC=C(N4CCN(CCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)N=C3)C=C21","","","","","","5.5","IC50 was assessed by an Alpha-Screen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c02234","855.009","854.411546068","4.91","63","8","11","3","14","179.04","C48H54N8O7","InChI=1S/C48H54N8O7/c1-6-31(5)55-27-29(3)42-35(44(58)50-26-36-28(2)22-30(4)51-45(36)59)23-33(24-38(42)55)32-12-14-40(49-25-32)54-19-17-53(18-20-54)16-7-8-21-63-39-11-9-10-34-43(39)48(62)56(47(34)61)37-13-15-41(57)52-46(37)60/h9-12,14,22-25,27,31,37H,6-8,13,15-21,26H2,1-5H3,(H,50,58)(H,51,59)(H,52,57,60)/t31-,37?/m0/s1","DHRDWOOGPTZPGD-RKBNTCOGSA-N"
"1760","Q15910","EZH2","CRBN","","","CC[C@H](C)N1C=C(C)C2=C(C(=O)NCC3=C(C)C=C(C)[NH]C3=O)C=C(C3=CC=C(N4CCN(CCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)N=C3)C=C21","","","","","","5.8","IC50 was assessed by an Alpha-Screen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c02234","869.036","868.427196132","5.27","64","8","11","3","15","179.04","C49H56N8O7","InChI=1S/C49H56N8O7/c1-6-32(5)56-28-30(3)43-36(45(59)51-27-37-29(2)23-31(4)52-46(37)60)24-34(25-39(43)56)33-13-15-41(50-26-33)55-20-18-54(19-21-55)17-8-7-9-22-64-40-12-10-11-35-44(40)49(63)57(48(35)62)38-14-16-42(58)53-47(38)61/h10-13,15,23-26,28,32,38H,6-9,14,16-22,27H2,1-5H3,(H,51,59)(H,52,60)(H,53,58,61)/t32-,38?/m0/s1","FHFDVRHANUQCAV-MDYKADOQSA-N"
"1761","Q15910","EZH2","CRBN","","","CC[C@H](C)N1C=C(C)C2=C(C(=O)NCC3=C(C)C=C(C)[NH]C3=O)C=C(C3=CC=C(N4CCN(CCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)N=C3)C=C21","","","","","","4","IC50 was assessed by an Alpha-Screen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c02234","883.063","882.442846196","5.62","65","8","11","3","16","179.04","C50H58N8O7","InChI=1S/C50H58N8O7/c1-6-33(5)57-29-31(3)44-37(46(60)52-28-38-30(2)24-32(4)53-47(38)61)25-35(26-40(44)57)34-14-16-42(51-27-34)56-21-19-55(20-22-56)18-9-7-8-10-23-65-41-13-11-12-36-45(41)50(64)58(49(36)63)39-15-17-43(59)54-48(39)62/h11-14,16,24-27,29,33,39H,6-10,15,17-23,28H2,1-5H3,(H,52,60)(H,53,61)(H,54,59,62)/t33-,39?/m0/s1","RLAAXGAAEWLCAE-YNWFVEANSA-N"
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"1777","O14744","PRMT5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","911.099","910.415979816","2.41","65","7","14","6","17","231.55","C46H58N10O8S","InChI=1S/C46H58N10O8S/c1-28-41(65-27-51-28)31-11-9-29(10-12-31)17-47-44(62)37-15-34(57)23-56(37)45(63)42(46(2,3)4)53-39(59)24-64-25-40(60)55-20-33(21-55)52-38-16-36(49-26-50-38)43(61)48-18-35(58)22-54-14-13-30-7-5-6-8-32(30)19-54/h5-12,16,26-27,33-35,37,42,57-58H,13-15,17-25H2,1-4H3,(H,47,62)(H,48,61)(H,53,59)(H,49,50,52)/t34-,35+,37+,42-/m1/s1","YOOOBBOFJGMJHA-LLWUYVORSA-N"
"1778","O14744","PRMT5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","983.206","982.473494692","2.07","70","7","15","6","22","240.78","C50H66N10O9S","InChI=1S/C50H66N10O9S/c1-32-45(70-31-55-32)35-11-9-33(10-12-35)23-51-48(66)41-21-38(61)29-60(41)49(67)46(50(2,3)4)57-43(63)14-17-68-19-20-69-18-15-44(64)59-26-37(27-59)56-42-22-40(53-30-54-42)47(65)52-24-39(62)28-58-16-13-34-7-5-6-8-36(34)25-58/h5-12,22,30-31,37-39,41,46,61-62H,13-21,23-29H2,1-4H3,(H,51,66)(H,52,65)(H,57,63)(H,53,54,56)/t38-,39+,41+,46-/m1/s1","JFHDSHQOCNOJNF-WWMOLYGISA-N"
"1779","O14744","PRMT5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","1027.259","1026.49970944","1.92","73","7","16","6","25","250.01","C52H70N10O10S","InChI=1S/C52H70N10O10S/c1-34-47(73-33-57-34)37-11-9-35(10-12-37)25-53-50(68)43-23-40(63)31-62(43)51(69)48(52(2,3)4)59-45(65)14-17-70-19-21-72-22-20-71-18-15-46(66)61-28-39(29-61)58-44-24-42(55-32-56-44)49(67)54-26-41(64)30-60-16-13-36-7-5-6-8-38(36)27-60/h5-12,24,32-33,39-41,43,48,63-64H,13-23,25-31H2,1-4H3,(H,53,68)(H,54,67)(H,59,65)(H,55,56,58)/t40-,41+,43+,48-/m1/s1","HPLAZGAIUCZNEX-RIRHZFCSSA-N"
"1780","O14744","PRMT5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","993.289","992.530615644","5.79","71","7","13","6","23","222.32","C53H72N10O7S","InChI=1S/C53H72N10O7S/c1-35-48(71-34-58-35)38-20-18-36(19-21-38)26-54-51(69)44-24-41(64)32-63(44)52(70)49(53(2,3)4)60-46(66)16-10-8-6-5-7-9-11-17-47(67)62-29-40(30-62)59-45-25-43(56-33-57-45)50(68)55-27-42(65)31-61-23-22-37-14-12-13-15-39(37)28-61/h12-15,18-21,25,33-34,40-42,44,49,64-65H,5-11,16-17,22-24,26-32H2,1-4H3,(H,54,69)(H,55,68)(H,60,66)(H,56,57,59)/t41-,42+,44+,49-/m1/s1","KNYPQOVXELOVHE-YLOBJFFCSA-N"
"1781","O14744","PRMT5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","1087.311","1086.52083881","1.82","77","7","18","6","29","268.47","C54H74N10O12S","InChI=1S/C54H74N10O12S/c1-36-49(77-35-59-36)39-11-9-37(10-12-39)25-55-52(70)45-23-42(65)31-64(45)53(71)50(54(2,3)4)61-47(67)32-75-21-19-73-17-15-72-16-18-74-20-22-76-33-48(68)63-28-41(29-63)60-46-24-44(57-34-58-46)51(69)56-26-43(66)30-62-14-13-38-7-5-6-8-40(38)27-62/h5-12,24,34-35,41-43,45,50,65-66H,13-23,25-33H2,1-4H3,(H,55,70)(H,56,69)(H,61,67)(H,57,58,60)/t42-,43+,45+,50-/m1/s1","IJHBBPTVQYEAGQ-MSDWBBBCSA-N"
"1782","O14744","PRMT5","VHL","","MS4322","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)N3CC(NC4=CC(C(=O)NC[C@H](O)CN5CCC6=CC=CC=C6C5)=NC=N4)C3)C(C)(C)C)C=C2)SC=N1","1100","74","Degradation of PRMT5 in MCF-7 cells after 6 d treatment","","","18","IC50 was assessed by a human PRMT5/MEP50 radioactive biochemical assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01111","1101.338","1100.53648887","2.22","78","7","18","6","29","268.47","C55H76N10O12S","InChI=1S/C55H76N10O12S/c1-36(38-10-12-40(13-11-38)50-37(2)59-35-78-50)60-53(71)46-24-43(66)31-65(46)54(72)51(55(3,4)5)62-48(68)32-76-22-20-74-18-16-73-17-19-75-21-23-77-33-49(69)64-28-42(29-64)61-47-25-45(57-34-58-47)52(70)56-26-44(67)30-63-15-14-39-8-6-7-9-41(39)27-63/h6-13,25,34-36,42-44,46,51,66-67H,14-24,26-33H2,1-5H3,(H,56,70)(H,60,71)(H,62,68)(H,57,58,61)/t36-,43+,44-,46-,51+/m0/s1","XUJMNOQMXWVXQE-STHBVIMFSA-N"
"1783","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC4=C(C=C3CS(C)(=O)=O)C3=CN(C)C(=O)C5=C3C(=C[NH]5)CN4C3=NC=C(F)C=C3F)C(C)(C)C)C=C2)SC=N1","7.5","98","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","1.1/1.4","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1102.253","1101.39000221","2.66","77","8","16","5","21","256.48","C53H61F2N9O11S2","InChI=1S/C53H61F2N9O11S2/c1-30-46(76-29-60-30)32-9-7-31(8-10-32)21-59-50(68)42-19-36(65)25-64(42)52(70)47(53(2,3)4)61-43(66)27-75-16-15-74-14-13-73-12-11-56-49(67)37-20-41-38(17-33(37)28-77(6,71)72)39-26-62(5)51(69)45-44(39)34(22-57-45)24-63(41)48-40(55)18-35(54)23-58-48/h7-10,17-18,20,22-23,26,29,36,42,47,57,65H,11-16,19,21,24-25,27-28H2,1-6H3,(H,56,67)(H,59,68)(H,61,66)/t36-,42+,47-/m1/s1","GPZQCKOJSPAJES-KFRCLFBHSA-N"
"1784","O60885","BRD4","VHL","7KHH","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)C3=CC4=C(C=C3CS(C)(=O)=O)C3=CN(C)C(=O)C5=C3C(=C[NH]5)CN4C3=NC=C(F)C=C3F)C(C)(C)C)C=C2)SC=N1","0.095","96","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","4.7/4.3","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","613","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.63","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1096.337","1095.45220854","6.78","77","8","13","5","21","228.79","C56H67F2N9O8S2","InChI=1S/C56H67F2N9O8S2/c1-33-49(76-32-63-33)35-18-16-34(17-19-35)25-62-53(71)45-23-39(68)29-67(45)55(73)50(56(2,3)4)64-46(69)15-13-11-9-7-8-10-12-14-20-59-52(70)40-24-44-41(21-36(40)31-77(6,74)75)42-30-65(5)54(72)48-47(42)37(26-60-48)28-66(44)51-43(58)22-38(57)27-61-51/h16-19,21-22,24,26-27,30,32,39,45,50,60,68H,7-15,20,23,25,28-29,31H2,1-6H3,(H,59,70)(H,62,71)(H,64,69)/t39-,45+,50-/m1/s1","VTPSYVSGGUUAFN-GDNJTPAESA-N"
"1785","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C3=CC4=C(C=C3CS(C)(=O)=O)C3=CN(C)C(=O)C5=C3C(=C[NH]5)CN4C3=NC=C(F)C=C3F)C(C)(C)C)C(OC3CCNCC3)=C2)SC=N1","180","99","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","1.2/1.6","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","383","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","220","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1201.386","1200.45841612","2.75","84","9","18","6","23","277.74","C58H70F2N10O12S2","InChI=1S/C58H70F2N10O12S2/c1-33-51(83-32-66-33)34-7-8-35(47(20-34)82-40-9-11-61-12-10-40)24-65-55(74)46-22-39(71)28-70(46)57(76)52(58(2,3)4)67-48(72)30-81-18-17-80-16-15-79-14-13-62-54(73)41-23-45-42(19-36(41)31-84(6,77)78)43-29-68(5)56(75)50-49(43)37(25-63-50)27-69(45)53-44(60)21-38(59)26-64-53/h7-8,19-21,23,25-26,29,32,39-40,46,52,61,63,71H,9-18,22,24,27-28,30-31H2,1-6H3,(H,62,73)(H,65,74)(H,67,72)/t39-,46+,52-/m1/s1","QZSIUKWWOMOSBP-MHQZIYKSSA-N"
"1786","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)C3=CC4=C(C=C3CS(C)(=O)=O)C3=CN(C)C(=O)C5=C3C(=C[NH]5)CN4C3=NC=C(F)C=C3F)C(C)(C)C)C(OC3CCNCC3)=C2)SC=N1","3.4","98","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","2/2.7","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","40","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1195.47","1194.52062245","6.88","84","9","15","6","23","250.05","C61H76F2N10O9S2","InChI=1S/C61H76F2N10O9S2/c1-36-54(83-35-69-36)37-16-17-38(50(24-37)82-43-18-21-64-22-19-43)28-68-58(77)49-26-42(74)32-73(49)60(79)55(61(2,3)4)70-51(75)15-13-11-9-7-8-10-12-14-20-65-57(76)44-27-48-45(23-39(44)34-84(6,80)81)46-33-71(5)59(78)53-52(46)40(29-66-53)31-72(48)56-47(63)25-41(62)30-67-56/h16-17,23-25,27,29-30,33,35,42-43,49,55,64,66,74H,7-15,18-22,26,28,31-32,34H2,1-6H3,(H,65,76)(H,68,77)(H,70,75)/t42-,49+,55-/m1/s1","QJBZJBJONOIDIV-GSTUPHOUSA-N"
"1787","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCC3=CC(N)=CC(OCCNC(=O)C4=CC5=C(C=C4CS(C)(=O)=O)C4=CN(C)C(=O)C6=C4C(=C[NH]6)CN5C4=NC=C(F)C=C4F)=C3)C(C)(C)C)C=C2)SC=N1","2.1","98","Degradation of BRD4 in EOL-1 cells 4 h treatment","","","7.2/8.1","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","91","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1149.313","1148.40598662","4.2","81","9","16","6","19","273.27","C57H62F2N10O10S2","InChI=1S/C57H62F2N10O10S2/c1-31-50(80-30-65-31)34-9-7-32(8-10-34)22-64-54(73)46-20-39(70)26-69(46)56(75)51(57(2,3)4)66-47(71)28-78-13-11-33-15-38(60)19-40(16-33)79-14-12-61-53(72)41-21-45-42(17-35(41)29-81(6,76)77)43-27-67(5)55(74)49-48(43)36(23-62-49)25-68(45)52-44(59)18-37(58)24-63-52/h7-10,15-19,21,23-24,27,30,39,46,51,62,70H,11-14,20,22,25-26,28-29,60H2,1-6H3,(H,61,72)(H,64,73)(H,66,71)/t39-,46+,51-/m1/s1","UNADZUGJDDCVKE-RVLLIKLQSA-N"
"1788","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCC3=CC(O)=CC(OCCNC(=O)C4=CC5=C(C=C4CS(C)(=O)=O)C4=CN(C)C(=O)C6=C4C(=C[NH]6)CN5C4=NC=C(F)C=C4F)=C3)C(C)(C)C)C=C2)SC=N1","1.4","100","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","1.8/1.7","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","229","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01846","1150.297","1149.39000221","4.52","81","9","16","6","19","267.48","C57H61F2N9O11S2","InChI=1S/C57H61F2N9O11S2/c1-31-50(80-30-64-31)34-9-7-32(8-10-34)22-63-54(73)46-20-39(70)26-68(46)56(75)51(57(2,3)4)65-47(71)28-78-13-11-33-15-38(69)19-40(16-33)79-14-12-60-53(72)41-21-45-42(17-35(41)29-81(6,76)77)43-27-66(5)55(74)49-48(43)36(23-61-49)25-67(45)52-44(59)18-37(58)24-62-52/h7-10,15-19,21,23-24,27,30,39,46,51,61,69-70H,11-14,20,22,25-26,28-29H2,1-6H3,(H,60,72)(H,63,73)(H,65,71)/t39-,46+,51-/m1/s1","JQHNOZDZLLPAJF-RVLLIKLQSA-N"
"1789","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(N)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1",">20000","","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","180/56","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5000","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","983.231","982.419350944","3.66","69","7","16","5","20","237.51","C49H62N10O8S2","InChI=1S/C49H62N10O8S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-16-17-65-18-19-66-20-21-67-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-8-10-34(11-9-32)43-29(2)53-27-68-43/h8-15,27,36-38,44,60H,16-26,50H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","XCXZOGOAQQLALD-PYNGZGNASA-N"
"1790","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(C#CCN)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","930","79","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","60/22","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","610","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2600","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1021.28","1020.43500101","3.59","72","7","16","5","20","237.51","C52H64N10O8S2","InChI=1S/C52H64N10O8S2/c1-31-33(3)72-51-44(31)45(37-14-10-35(11-15-37)9-8-18-53)57-40(48-60-59-34(4)62(48)51)26-42(64)54-19-20-68-21-22-69-23-24-70-29-43(65)58-47(52(5,6)7)50(67)61-28-39(63)25-41(61)49(66)55-27-36-12-16-38(17-13-36)46-32(2)56-30-71-46/h10-17,30,39-41,47,63H,18-29,53H2,1-7H3,(H,54,64)(H,55,66)(H,58,65)/t39-,40+,41+,47-/m1/s1","RJYPXJLNNMXFMD-XRFVFAKVSA-N"
"1791","O60885","BRD4","VHL","","","CNCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=C(SC(C)=C2C)N2C(C)=NN=C12)C(C)(C)C","780","99","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","34/10","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","720","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2800","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1075.756","1074.4222434","4.51","74","7","17","5","24","232.75","C52H67ClN10O9S2","InChI=1S/C52H67ClN10O9S2/c1-30-32(3)74-51-44(30)45(34-11-13-37(53)14-12-34)58-39(48-61-60-33(4)63(48)51)25-42(65)55-16-17-69-19-20-70-21-22-71-28-43(66)59-47(52(5,6)7)50(68)62-27-38(64)24-40(62)49(67)56-26-36-10-9-35(46-31(2)57-29-73-46)23-41(36)72-18-15-54-8/h9-14,23,29,38-40,47,54,64H,15-22,24-28H2,1-8H3,(H,55,65)(H,56,67)(H,59,66)/t38-,39+,40+,47-/m1/s1","AFQYUHBTQNKWIU-KVLVHDNBSA-N"
"1792","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C(OC3CCNCC3)=C2)SC=N1","350","100","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","35/11","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","520","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2700","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1101.794","1100.43789347","5.06","76","8","17","5","22","232.75","C54H69ClN10O9S2","InChI=1S/C54H69ClN10O9S2/c1-31-33(3)76-53-46(31)47(35-10-12-38(55)13-11-35)60-41(50-63-62-34(4)65(50)53)26-44(67)57-18-19-71-20-21-72-22-23-73-29-45(68)61-49(54(5,6)7)52(70)64-28-39(66)25-42(64)51(69)58-27-37-9-8-36(48-32(2)59-30-75-48)24-43(37)74-40-14-16-56-17-15-40/h8-13,24,30,39-42,49,56,66H,14-23,25-29H2,1-7H3,(H,57,67)(H,58,69)(H,61,68)/t39-,41+,42+,49-/m1/s1","FOJOYRKGPBBUCX-BCSSRTCSSA-N"
"1793","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCC3=CC(N)=CC(OCCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)=C3)C(C)(C)C)C=C2)SC=N1","85","98","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","208/69","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","135","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1300","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1049.721","1048.38546397","6.51","73","8","15","5","18","228.28","C53H61ClN10O7S2","InChI=1S/C53H61ClN10O7S2/c1-29-31(3)73-52-45(29)46(35-12-14-37(54)15-13-35)59-41(49-62-61-32(4)64(49)52)24-43(66)56-17-19-71-40-21-34(20-38(55)22-40)16-18-70-27-44(67)60-48(53(5,6)7)51(69)63-26-39(65)23-42(63)50(68)57-25-33-8-10-36(11-9-33)47-30(2)58-28-72-47/h8-15,20-22,28,39,41-42,48,65H,16-19,23-27,55H2,1-7H3,(H,56,66)(H,57,68)(H,60,67)/t39-,41+,42+,48-/m1/s1","BVEMTZIKXNJFIM-NMNKMPBPSA-N"
"1794","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COC[C@@H]3CNC[C@H](COCCNC(=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C5=C(SC(C)=C5C)N5C(C)=NN=C45)C3)C(C)(C)C)C=C2)SC=N1","280","88","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","12/6.4","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","570","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3800","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1041.742","1040.4167641","5.33","72","8","15","5","18","214.29","C52H65ClN10O7S2","InChI=1S/C52H65ClN10O7S2/c1-29-31(3)72-51-44(29)45(36-12-14-38(53)15-13-36)58-40(48-61-60-32(4)63(48)51)20-42(65)55-16-17-69-25-34-18-35(22-54-21-34)26-70-27-43(66)59-47(52(5,6)7)50(68)62-24-39(64)19-41(62)49(67)56-23-33-8-10-37(11-9-33)46-30(2)57-28-71-46/h8-15,28,34-35,39-41,47,54,64H,16-27H2,1-7H3,(H,55,65)(H,56,67)(H,59,66)/t34-,35+,39-,40+,41+,47-/m1/s1","XYRCFJBQFAIJBP-MFCIJMLGSA-N"
"1795","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCC3=CC(N)=CC(CCOCCOCC#CC4=CC=C(C5=N[C@@H](CC6=NC=CS6)C6=NN=C(C)N6C6=C5C(C)=C(C)S6)C=C4)=C3)C(C)(C)C)C=C2)SC=N1","87","100","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","55/40","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","440","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","480","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1107.442","1106.43289283","7.89","78","9","16","4","19","212.07","C59H66N10O6S3","InChI=1S/C59H66N10O6S3/c1-35-37(3)78-58-51(35)52(64-47(31-50-61-21-26-76-50)55-67-66-38(4)69(55)58)43-15-10-39(11-16-43)9-8-22-74-24-25-75-23-20-42-27-41(28-45(60)29-42)14-19-49(71)65-54(59(5,6)7)57(73)68-33-46(70)30-48(68)56(72)62-32-40-12-17-44(18-13-40)53-36(2)63-34-77-53/h10-13,15-18,21,26-29,34,46-48,54,70H,14,19-20,22-25,30-33,60H2,1-7H3,(H,62,72)(H,65,71)/t46-,47+,48+,54-/m1/s1","MXYBZGJJYHQKSU-OSCONUCQSA-N"
"1796","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCC3=CC(N)=CC(CCOCCOCC#CC4=CC=C(C5=N[C@@H](CC(=O)NCCS(=O)(=O)O)C6=NN=C(C)N6C6=C5C(C)=C(C)S6)C=C4)=C3)C(C)(C)C)C=C2)SC=N1","6500","100","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","18/13","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11000","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","1175.47","1174.44385144","5.0","82","8","17","6","22","282.65","C59H70N10O10S3","InChI=1S/C59H70N10O10S3/c1-35-37(3)81-58-51(35)52(64-47(55-67-66-38(4)69(55)58)31-50(72)61-21-26-82(75,76)77)43-15-10-39(11-16-43)9-8-22-78-24-25-79-23-20-42-27-41(28-45(60)29-42)14-19-49(71)65-54(59(5,6)7)57(74)68-33-46(70)30-48(68)56(73)62-32-40-12-17-44(18-13-40)53-36(2)63-34-80-53/h10-13,15-18,27-29,34,46-48,54,70H,14,19-26,30-33,60H2,1-7H3,(H,61,72)(H,62,73)(H,65,71)(H,75,76,77)/t46-,47+,48+,54-/m1/s1","JSCBAQVBPQZYHJ-OSCONUCQSA-N"
"1797","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC#CC#CCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","7.2","99","Degradation of BRD4 in PC3-S1 cells after 4 h treatment","","","62/24","IC50 of BRD4 BD1/BD2 was tested by TR-FRET","","","","","","","","","","","","","","","470","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","67","Inhibit proliferation of PC3-S1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.0c01845","962.599","961.317050064","5.71","67","7","13","4","13","193.03","C49H52ClN9O6S2","InChI=1S/C49H52ClN9O6S2/c1-28-30(3)67-48-41(28)42(33-16-18-35(50)19-17-33)54-37(45-57-56-31(4)59(45)48)23-39(61)51-20-10-8-9-11-21-65-26-40(62)55-44(49(5,6)7)47(64)58-25-36(60)22-38(58)46(63)52-24-32-12-14-34(15-13-32)43-29(2)53-27-66-43/h12-19,27,36-38,44,60H,20-26H2,1-7H3,(H,51,61)(H,52,63)(H,55,62)/t36-,37+,38+,44-/m1/s1","FXEIENSZGMCCEE-PYNGZGNASA-N"
"1798","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","776.773","776.289380248","4.06","56","6","11","4","13","193.72","C38H39F3N8O7","InChI=1S/C38H39F3N8O7/c1-5-56-27-19-23-26(18-24(27)46-32(51)22-10-7-11-28(44-22)38(39,40)41)48(4)29(45-23)14-15-37(2,3)36(55)43-17-16-42-21-9-6-8-20-31(21)35(54)49(34(20)53)25-12-13-30(50)47-33(25)52/h6-11,18-19,25,42H,5,12-17H2,1-4H3,(H,43,55)(H,46,51)(H,47,50,52)","NRWFFPQGMFSFQM-UHFFFAOYSA-N"
"1799","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","790.8","790.305030312","4.42","57","6","11","4","14","193.72","C39H41F3N8O7","InChI=1S/C39H41F3N8O7/c1-5-57-28-20-24-27(19-25(28)47-33(52)23-11-7-12-29(45-23)39(40,41)42)49(4)30(46-24)15-16-38(2,3)37(56)44-18-8-17-43-22-10-6-9-21-32(22)36(55)50(35(21)54)26-13-14-31(51)48-34(26)53/h6-7,9-12,19-20,26,43H,5,8,13-18H2,1-4H3,(H,44,56)(H,47,52)(H,48,51,53)","GFJJTULDZFOWDS-UHFFFAOYSA-N"
"1800","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","804.827","804.320680376","4.78","58","6","11","4","15","193.72","C40H43F3N8O7","InChI=1S/C40H43F3N8O7/c1-5-58-29-21-25-28(20-26(29)48-34(53)24-12-9-13-30(46-24)40(41,42)43)50(4)31(47-25)16-17-39(2,3)38(57)45-19-7-6-18-44-23-11-8-10-22-33(23)37(56)51(36(22)55)27-14-15-32(52)49-35(27)54/h8-13,20-21,27,44H,5-7,14-19H2,1-4H3,(H,45,57)(H,48,53)(H,49,52,54)","WZOCYUIHCJWDCN-UHFFFAOYSA-N"
"1801","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","818.854","818.33633044","5.13","59","6","11","4","16","193.72","C41H45F3N8O7","InChI=1S/C41H45F3N8O7/c1-5-59-30-22-26-29(21-27(30)49-35(54)25-13-10-14-31(47-25)41(42,43)44)51(4)32(48-26)17-18-40(2,3)39(58)46-20-8-6-7-19-45-24-12-9-11-23-34(24)38(57)52(37(23)56)28-15-16-33(53)50-36(28)55/h9-14,21-22,28,45H,5-8,15-20H2,1-4H3,(H,46,58)(H,49,54)(H,50,53,55)","WXFYHPZKCQMNPI-UHFFFAOYSA-N"
"1802","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","832.881","832.351980504","5.49","60","6","11","4","17","193.72","C42H47F3N8O7","InChI=1S/C42H47F3N8O7/c1-5-60-31-23-27-30(22-28(31)50-36(55)26-14-11-15-32(48-26)42(43,44)45)52(4)33(49-27)18-19-41(2,3)40(59)47-21-9-7-6-8-20-46-25-13-10-12-24-35(25)39(58)53(38(24)57)29-16-17-34(54)51-37(29)56/h10-15,22-23,29,46H,5-9,16-21H2,1-4H3,(H,47,59)(H,50,55)(H,51,54,56)","NNHCYILMHUGOAG-UHFFFAOYSA-N"
"1803","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCCCCCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","846.908","846.367630568","6.03","61","6","11","4","18","193.72","C43H49F3N8O7","InChI=1S/C43H49F3N8O7/c1-5-61-32-24-28-31(23-29(32)51-37(56)27-15-12-16-33(49-27)43(44,45)46)53(4)34(50-28)19-20-42(2,3)41(60)48-22-10-8-6-7-9-21-47-26-14-11-13-25-36(26)40(59)54(39(25)58)30-17-18-35(55)52-38(30)57/h11-16,23-24,30,47H,5-10,17-22H2,1-4H3,(H,48,60)(H,51,56)(H,52,55,57)","UYJDCNGDEFZNHZ-UHFFFAOYSA-N"
"1804","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCOCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","820.826","820.315594996","3.91","59","6","12","4","16","202.95","C40H43F3N8O8","InChI=1S/C40H43F3N8O8/c1-5-59-29-21-25-28(20-26(29)48-34(53)24-10-7-11-30(46-24)40(41,42)43)50(4)31(47-25)14-15-39(2,3)38(57)45-17-19-58-18-16-44-23-9-6-8-22-33(23)37(56)51(36(22)55)27-12-13-32(52)49-35(27)54/h6-11,20-21,27,44H,5,12-19H2,1-4H3,(H,45,57)(H,48,53)(H,49,52,54)","GCUKHYXCNUZAKQ-UHFFFAOYSA-N"
"1805","Q9NWZ3","IRAK4","CRBN","","","CCOC1=CC2=C(C=C1NC(=O)C1=CC=CC(C(F)(F)F)=N1)N(C)C(CCC(C)(C)C(=O)NCCOCCOCCNC1=CC=CC3=C1C(=O)N(C1CCC(=O)NC1=O)C3=O)=N2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4600/7600","Inhibit proliferation of OCI-LY10/TMD8 cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00474","864.879","864.341809744","3.77","62","6","13","4","19","212.18","C42H47F3N8O9","InChI=1S/C42H47F3N8O9/c1-5-62-31-23-27-30(22-28(31)50-36(55)26-10-7-11-32(48-26)42(43,44)45)52(4)33(49-27)14-15-41(2,3)40(59)47-17-19-61-21-20-60-18-16-46-25-9-6-8-24-35(25)39(58)53(38(24)57)29-12-13-34(54)51-37(29)56/h6-11,22-23,29,46H,5,12-21H2,1-4H3,(H,47,59)(H,50,55)(H,51,54,56)","NOBOQMWAZRMLTM-UHFFFAOYSA-N"
"1806","Q05397","FAK","CRBN","","FC-1","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","37/71","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","920.892","920.274809868","0.95","65","7","18","5","18","277.62","C39H39F3N14O8S","InChI=1S/C39H39F3N14O8S/c1-54(65(2,62)63)33-28(43-12-13-45-33)20-46-32-26(39(40,41)42)19-48-38(51-32)49-23-8-6-22(7-9-23)34(58)47-18-24-21-55(53-52-24)15-17-64-16-14-44-27-5-3-4-25-31(27)37(61)56(36(25)60)29-10-11-30(57)50-35(29)59/h3-9,12-13,19,21,29,44H,10-11,14-18,20H2,1-2H3,(H,47,58)(H,50,57,59)(H2,46,48,49,51)","ZCIGAWLQIQHALM-UHFFFAOYSA-N"
"1807","Q05397","FAK","CRBN","","FC-2","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","32/60","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","964.945","964.301024616","0.8","68","7","19","5","21","286.85","C41H43F3N14O9S","InChI=1S/C41H43F3N14O9S/c1-56(68(2,64)65)35-30(45-12-13-47-35)22-48-34-28(41(42,43)44)21-50-40(53-34)51-25-8-6-24(7-9-25)36(60)49-20-26-23-57(55-54-26)15-17-67-19-18-66-16-14-46-29-5-3-4-27-33(29)39(63)58(38(27)62)31-10-11-32(59)52-37(31)61/h3-9,12-13,21,23,31,46H,10-11,14-20,22H2,1-2H3,(H,49,60)(H,52,59,61)(H2,48,50,51,53)","HFHJPCGVORVJEM-UHFFFAOYSA-N"
"1808","Q05397","FAK","CRBN","","FC-3","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","5/22","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","1008.998","1008.32723936","0.65","71","7","20","5","24","296.08","C43H47F3N14O10S","InChI=1S/C43H47F3N14O10S/c1-58(71(2,66)67)37-32(47-12-13-49-37)24-50-36-30(43(44,45)46)23-52-42(55-36)53-27-8-6-26(7-9-27)38(62)51-22-28-25-59(57-56-28)15-17-69-19-21-70-20-18-68-16-14-48-31-5-3-4-29-35(31)41(65)60(40(29)64)33-10-11-34(61)54-39(33)63/h3-9,12-13,23,25,33,48H,10-11,14-22,24H2,1-2H3,(H,51,62)(H,54,61,63)(H2,50,52,53,55)","SWVYRPQUTONQRV-UHFFFAOYSA-N"
"1809","Q05397","FAK","CRBN","","FC-4","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","55/81","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","919.904","919.2795609","1.98","65","7","17","5","18","264.73","C40H40F3N13O8S","InChI=1S/C40H40F3N13O8S/c1-54(65(2,62)63)34-24(5-4-14-45-34)19-46-33-28(40(41,42)43)21-48-39(51-33)49-25-10-8-23(9-11-25)35(58)47-20-26-22-55(53-52-26)16-18-64-17-15-44-29-7-3-6-27-32(29)38(61)56(37(27)60)30-12-13-31(57)50-36(30)59/h3-11,14,21-22,30,44H,12-13,15-20H2,1-2H3,(H,47,58)(H,50,57,59)(H2,46,48,49,51)","YKYLBDUVVSFNHK-UHFFFAOYSA-N"
"1810","Q05397","FAK","CRBN","","FC-5","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","40/65","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","963.957","963.305775648","1.83","68","7","18","5","21","273.96","C42H44F3N13O9S","InChI=1S/C42H44F3N13O9S/c1-56(68(2,64)65)36-26(5-4-14-47-36)21-48-35-30(42(43,44)45)23-50-41(53-35)51-27-10-8-25(9-11-27)37(60)49-22-28-24-57(55-54-28)16-18-67-20-19-66-17-15-46-31-7-3-6-29-34(31)40(63)58(39(29)62)32-12-13-33(59)52-38(32)61/h3-11,14,23-24,32,46H,12-13,15-22H2,1-2H3,(H,49,60)(H,52,59,61)(H2,48,50,51,53)","PKVORWUTBARDDH-UHFFFAOYSA-N"
"1811","Q05397","FAK","CRBN","","FC-6","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(C(=O)NCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","10/30","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","1008.01","1007.3319904","1.69","71","7","19","5","24","283.19","C44H48F3N13O10S","InChI=1S/C44H48F3N13O10S/c1-58(71(2,66)67)38-28(5-4-14-49-38)23-50-37-32(44(45,46)47)25-52-43(55-37)53-29-10-8-27(9-11-29)39(62)51-24-30-26-59(57-56-30)16-18-69-20-22-70-21-19-68-17-15-48-33-7-3-6-31-36(33)42(65)60(41(31)64)34-12-13-35(61)54-40(34)63/h3-11,14,25-26,34,48H,12-13,15-24H2,1-2H3,(H,51,62)(H,54,61,63)(H2,50,52,53,55)","LCIKYUVWQAEKNS-UHFFFAOYSA-N"
"1812","Q05397","FAK","CRBN","","FC-7","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","32/90","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","906.865","906.259159804","1.31","64","7","18","5","17","277.62","C38H37F3N14O8S","InChI=1S/C38H37F3N14O8S/c1-53(64(2,61)62)32-26(42-12-13-44-32)19-45-31-24(38(39,40)41)18-46-37(50-31)48-22-8-6-21(7-9-22)47-33(57)27-20-54(52-51-27)15-17-63-16-14-43-25-5-3-4-23-30(25)36(60)55(35(23)59)28-10-11-29(56)49-34(28)58/h3-9,12-13,18,20,28,43H,10-11,14-17,19H2,1-2H3,(H,47,57)(H,49,56,58)(H2,45,46,48,50)","ZYXULQSSGRJULY-UHFFFAOYSA-N"
"1813","Q05397","FAK","CRBN","","FC-8","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","71/96","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","950.918","950.285374552","1.16","67","7","19","5","20","286.85","C40H41F3N14O9S","InChI=1S/C40H41F3N14O9S/c1-55(67(2,63)64)34-28(44-12-13-46-34)21-47-33-26(40(41,42)43)20-48-39(52-33)50-24-8-6-23(7-9-24)49-35(59)29-22-56(54-53-29)15-17-66-19-18-65-16-14-45-27-5-3-4-25-32(27)38(62)57(37(25)61)30-10-11-31(58)51-36(30)60/h3-9,12-13,20,22,30,45H,10-11,14-19,21H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","WSSLMXUFNPNQOC-UHFFFAOYSA-N"
"1814","Q05397","FAK","CRBN","","FC-9","CN(C1=NC=CN=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","35/92","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","994.971","994.3115893","1.01","70","7","20","5","23","296.08","C42H45F3N14O10S","InChI=1S/C42H45F3N14O10S/c1-57(70(2,65)66)36-30(46-12-13-48-36)23-49-35-28(42(43,44)45)22-50-41(54-35)52-26-8-6-25(7-9-26)51-37(61)31-24-58(56-55-31)15-17-68-19-21-69-20-18-67-16-14-47-29-5-3-4-27-34(29)40(64)59(39(27)63)32-10-11-33(60)53-38(32)62/h3-9,12-13,22,24,32,47H,10-11,14-21,23H2,1-2H3,(H,51,61)(H,53,60,62)(H2,49,50,52,54)","HJCPWLDOKFFNBA-UHFFFAOYSA-N"
"1815","Q05397","FAK","CRBN","","FC-10","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","40/92","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","905.877","905.263910836","2.34","64","7","17","5","17","264.73","C39H38F3N13O8S","InChI=1S/C39H38F3N13O8S/c1-53(64(2,61)62)33-22(5-4-14-44-33)19-45-32-26(39(40,41)42)20-46-38(50-32)48-24-10-8-23(9-11-24)47-34(57)28-21-54(52-51-28)16-18-63-17-15-43-27-7-3-6-25-31(27)37(60)55(36(25)59)29-12-13-30(56)49-35(29)58/h3-11,14,20-21,29,43H,12-13,15-19H2,1-2H3,(H,47,57)(H,49,56,58)(H2,45,46,48,50)","OMFFNJHWWMOLMP-UHFFFAOYSA-N"
"1816","Q05397","FAK","CRBN","","FC-12","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","46/94","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","993.983","993.316340332","2.05","70","7","19","5","23","283.19","C43H46F3N13O10S","InChI=1S/C43H46F3N13O10S/c1-57(70(2,65)66)37-26(5-4-14-48-37)23-49-36-30(43(44,45)46)24-50-42(54-36)52-28-10-8-27(9-11-28)51-38(61)32-25-58(56-55-32)16-18-68-20-22-69-21-19-67-17-15-47-31-7-3-6-29-35(31)41(64)59(40(29)63)33-12-13-34(60)53-39(33)62/h3-11,14,24-25,33,47H,12-13,15-23H2,1-2H3,(H,51,61)(H,53,60,62)(H2,49,50,52,54)","YBMPYUQIBZJXCZ-UHFFFAOYSA-N"
"1817","Q05397","FAK","CRBN","","FC-13","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","30/82","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","1038.036","1037.34255508","1.9","73","7","20","5","26","292.42","C45H50F3N13O11S","InChI=1S/C45H50F3N13O11S/c1-59(73(2,67)68)39-28(5-4-14-50-39)25-51-38-32(45(46,47)48)26-52-44(56-38)54-30-10-8-29(9-11-30)53-40(63)34-27-60(58-57-34)16-18-70-20-22-72-24-23-71-21-19-69-17-15-49-33-7-3-6-31-37(33)43(66)61(42(31)65)35-12-13-36(62)55-41(35)64/h3-11,14,26-27,35,49H,12-13,15-25H2,1-2H3,(H,53,63)(H,55,62,64)(H2,51,52,54,56)","SDUQBXCEGLRTPJ-UHFFFAOYSA-N"
"1818","Q05397","FAK","CRBN","","FC-14","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","67/93","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","945.986","945.331596472","5.0","67","7","16","5","20","255.5","C43H46F3N13O7S","InChI=1S/C43H46F3N13O7S/c1-57(67(2,65)66)37-26(11-10-21-48-37)23-49-36-30(43(44,45)46)24-50-42(54-36)52-28-16-14-27(15-17-28)51-38(61)32-25-58(56-55-32)22-8-6-4-3-5-7-20-47-31-13-9-12-29-35(31)41(64)59(40(29)63)33-18-19-34(60)53-39(33)62/h9-17,21,24-25,33,47H,3-8,18-20,22-23H2,1-2H3,(H,51,61)(H,53,60,62)(H2,49,50,52,54)","TYDQETWWOPRUFW-UHFFFAOYSA-N"
"1819","Q05397","FAK","CRBN","","FC-15","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCC#CC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","62/90","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","944.91","944.263576488","1.85","67","7","17","4","17","261.93","C42H39F3N12O9S","InChI=1S/C42H39F3N12O9S/c1-55(67(2,63)64)36-26(7-4-16-46-36)22-47-35-30(42(43,44)45)23-48-41(52-35)50-28-12-10-27(11-13-28)49-37(59)31-24-56(54-53-31)17-19-66-21-20-65-18-5-8-25-6-3-9-29-34(25)40(62)57(39(29)61)32-14-15-33(58)51-38(32)60/h3-4,6-7,9-13,16,23-24,32H,14-15,17-22H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","AEQCSXCPHFZTNV-UHFFFAOYSA-N"
"1820","Q05397","FAK","CRBN","","FC-16","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCCCCOCC#CC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","62/90","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","942.938","942.284311932","3.07","67","7","16","4","17","252.7","C43H41F3N12O8S","InChI=1S/C43H41F3N12O8S/c1-56(67(2,64)65)37-27(10-7-19-47-37)23-48-36-31(43(44,45)46)24-49-42(53-36)51-29-15-13-28(14-16-29)50-38(60)32-25-57(55-54-32)20-4-3-5-21-66-22-8-11-26-9-6-12-30-35(26)41(63)58(40(30)62)33-17-18-34(59)52-39(33)61/h6-7,9-10,12-16,19,24-25,33H,3-5,17-18,20-23H2,1-2H3,(H,50,60)(H,52,59,61)(H2,48,49,51,53)","FEZJNHIIMHWZTF-UHFFFAOYSA-N"
"1821","Q05397","FAK","CRBN","","FC-17","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCCCCCCC#CC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","62/90","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","940.966","940.305047376","4.95","67","7","15","4","17","243.47","C44H43F3N12O7S","InChI=1S/C44H43F3N12O7S/c1-57(67(2,65)66)38-28(14-11-22-48-38)24-49-37-32(44(45,46)47)25-50-43(54-37)52-30-18-16-29(17-19-30)51-39(61)33-26-58(56-55-33)23-9-7-5-3-4-6-8-12-27-13-10-15-31-36(27)42(64)59(41(31)63)34-20-21-35(60)53-40(34)62/h10-11,13-19,22,25-26,34H,3-7,9,20-21,23-24H2,1-2H3,(H,51,61)(H,53,60,62)(H2,49,50,52,54)","PBHLTZUVDXLJQZ-UHFFFAOYSA-N"
"1822","Q05397","FAK","CRBN","","FC-18","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCOCCOCCCC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","85/95","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","948.942","948.294876616","2.28","67","7","17","4","20","261.93","C42H43F3N12O9S","InChI=1S/C42H43F3N12O9S/c1-55(67(2,63)64)36-26(7-4-16-46-36)22-47-35-30(42(43,44)45)23-48-41(52-35)50-28-12-10-27(11-13-28)49-37(59)31-24-56(54-53-31)17-19-66-21-20-65-18-5-8-25-6-3-9-29-34(25)40(62)57(39(29)61)32-14-15-33(58)51-38(32)60/h3-4,6-7,9-13,16,23-24,32H,5,8,14-15,17-22H2,1-2H3,(H,49,59)(H,51,58,60)(H2,47,48,50,52)","GNTSSXPDCUGXDV-UHFFFAOYSA-N"
"1823","Q05397","FAK","CRBN","","FC-19","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCCCCOCCCC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","62/90","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","946.97","946.31561206","3.5","67","7","16","4","20","252.7","C43H45F3N12O8S","InChI=1S/C43H45F3N12O8S/c1-56(67(2,64)65)37-27(10-7-19-47-37)23-48-36-31(43(44,45)46)24-49-42(53-36)51-29-15-13-28(14-16-29)50-38(60)32-25-57(55-54-32)20-4-3-5-21-66-22-8-11-26-9-6-12-30-35(26)41(63)58(40(30)62)33-17-18-34(59)52-39(33)61/h6-7,9-10,12-16,19,24-25,33H,3-5,8,11,17-18,20-23H2,1-2H3,(H,50,60)(H,52,59,61)(H2,48,49,51,53)","DRKWCHHTECNTEC-UHFFFAOYSA-N"
"1824","Q05397","FAK","CRBN","","FC-20","CN(C1=NC=CC=C1CNC1=NC(NC2=CC=C(NC(=O)C3=CN(CCCCCCCCCC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O","","","","40/85","% FAK degradation in PA1 cells after 8 h treatment at 1/10 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.9b00372","944.998","944.336347504","5.64","67","7","15","4","20","243.47","C44H47F3N12O7S","InChI=1S/C44H47F3N12O7S/c1-57(67(2,65)66)38-28(14-11-22-48-38)24-49-37-32(44(45,46)47)25-50-43(54-37)52-30-18-16-29(17-19-30)51-39(61)33-26-58(56-55-33)23-9-7-5-3-4-6-8-12-27-13-10-15-31-36(27)42(64)59(41(31)63)34-20-21-35(60)53-40(34)62/h10-11,13-19,22,25-26,34H,3-9,12,20-21,23-24H2,1-2H3,(H,51,61)(H,53,60,62)(H2,49,50,52,54)","WWPUSLMSNQTZNH-UHFFFAOYSA-N"
"1825","Q8IXJ6","SIRT2","CRBN","","TM-P2-Thal","CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)CCOCCOCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC=C1","","","","","","69/170","Inhibit SIRT2 deacetylase/defatty-acylase","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00423","849.108","848.450634008","7.88","60","4","10","5","30","184.27","C45H64N6O8S","InChI=1S/C45H64N6O8S/c1-2-3-4-5-6-7-8-9-10-11-15-24-40(60)46-28-17-16-22-36(42(54)48-33-19-13-12-14-20-33)49-39(53)27-29-58-30-31-59-32-47-35-23-18-21-34-41(35)45(57)51(44(34)56)37-25-26-38(52)50-43(37)55/h12-14,18-21,23,36-37,47H,2-11,15-17,22,24-32H2,1H3,(H,46,60)(H,48,54)(H,49,53)(H,50,52,55)/t36-,37?/m0/s1","YVUHJCIRPWMCBK-NWDJCJOJSA-N"
"1826","Q8IXJ6","SIRT2","CRBN","","TM-P4-Thal","CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)NC1=CC=CC=C1","","","","","","78/110","Inhibit SIRT2 deacetylase/defatty-acylase","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00423","937.214","936.503063504","7.58","66","4","12","5","36","202.73","C49H72N6O10S","InChI=1S/C49H72N6O10S/c1-2-3-4-5-6-7-8-9-10-11-15-24-44(66)50-28-17-16-22-40(46(58)52-37-19-13-12-14-20-37)53-43(57)27-29-62-30-31-63-32-33-64-34-35-65-36-51-39-23-18-21-38-45(39)49(61)55(48(38)60)41-25-26-42(56)54-47(41)59/h12-14,18-21,23,40-41,51H,2-11,15-17,22,24-36H2,1H3,(H,50,66)(H,52,58)(H,53,57)(H,54,56,59)/t40-,41?/m0/s1","YKBLYBLKPUHNLS-KCXVWBLISA-N"
"1827","O60760","HPGDS","CRBN","","PROTAC(H-PGDS)-1","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCC(=O)N4CCN(C(=O)C5CCN(C6=CC=C(NC(=O)C7=CN=C(OC8=CC=CC=C8)N=C7)C=C6)CC5)CC4)=C3C2=O)C(=O)N1","","","","","","320","IC50 was assessed by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00605","1034.137","1033.45453308","1.88","75","8","17","3","26","249.7","C53H63N9O13","InChI=1S/C53H63N9O13/c63-45-14-13-44(49(66)58-45)62-51(68)42-7-4-8-43(47(42)52(62)69)54-18-26-71-28-30-73-32-34-74-33-31-72-29-27-70-25-17-46(64)60-21-23-61(24-22-60)50(67)37-15-19-59(20-16-37)40-11-9-39(10-12-40)57-48(65)38-35-55-53(56-36-38)75-41-5-2-1-3-6-41/h1-12,35-37,44,54H,13-34H2,(H,57,65)(H,58,63,66)","VAAKJPHNXBEVBP-UHFFFAOYSA-N"
"1828","O60760","HPGDS","cIAP1","","SNIPER(H-PGDS)-1","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCC(=O)N3CCN(C(=O)C4CCN(C5=CC=C(NC(=O)C6=CN=C(OC7=CC=CC=C7)N=C6)C=C5)CC4)CC3)=C2)=CS1)C1CCCCC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00605","1113.352","1112.5153595","5.96","80","9","16","3","23","227.06","C59H72N10O10S","InChI=1S/C59H72N10O10S/c1-40(60-2)54(72)65-52(41-11-5-3-6-12-41)58(75)69-24-10-17-50(69)56-64-49(39-80-56)53(71)43-13-9-16-48(35-43)78-34-33-76-31-32-77-38-51(70)67-27-29-68(30-28-67)57(74)42-22-25-66(26-23-42)46-20-18-45(19-21-46)63-55(73)44-36-61-59(62-37-44)79-47-14-7-4-8-15-47/h4,7-9,13-16,18-21,35-37,39-42,50,52,60H,3,5-6,10-12,17,22-34,38H2,1-2H3,(H,63,73)(H,65,72)/t40-,50-,52-/m0/s1","SXXOFFJATGUTIT-FBPQELFASA-N"
"1829","P14902","IDO1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)COCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","746.551","745.161949336","0.72","49","5","13","6","16","221.64","C30H33BrFN9O8","InChI=1S/C30H33BrFN9O8/c31-20-14-17(4-5-21(20)32)35-28(38-46)26-27(40-49-39-26)34-9-8-33-10-11-47-12-13-48-16-25(43)36-22-3-1-2-18-19(22)15-41(30(18)45)23-6-7-24(42)37-29(23)44/h1-5,14,23,33,46H,6-13,15-16H2,(H,34,40)(H,35,38)(H,36,43)(H,37,42,44)","DAEHHDDUURMTNL-UHFFFAOYSA-N"
"1830","P14902","IDO1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)COCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","790.604","789.188164084","0.57","52","5","14","6","19","230.87","C32H37BrFN9O9","InChI=1S/C32H37BrFN9O9/c33-22-16-19(4-5-23(22)34)37-30(40-48)28-29(42-52-41-28)36-9-8-35-10-11-49-12-13-50-14-15-51-18-27(45)38-24-3-1-2-20-21(24)17-43(32(20)47)25-6-7-26(44)39-31(25)46/h1-5,16,25,35,48H,6-15,17-18H2,(H,36,42)(H,37,40)(H,38,45)(H,39,44,46)","KDFPOECSAQSOFF-UHFFFAOYSA-N"
"1831","P14902","IDO1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)COCCOCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)C=CC=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","834.657","833.214378832","0.43","55","5","15","6","22","240.1","C34H41BrFN9O10","InChI=1S/C34H41BrFN9O10/c35-24-18-21(4-5-25(24)36)39-32(42-50)30-31(44-55-43-30)38-9-8-37-10-11-51-12-13-52-14-15-53-16-17-54-20-29(47)40-26-3-1-2-22-23(26)19-45(34(22)49)27-6-7-28(46)41-33(27)48/h1-5,18,27,37,50H,6-17,19-20H2,(H,38,44)(H,39,42)(H,40,47)(H,41,46,48)","VIACJOIWGKKFOO-UHFFFAOYSA-N"
"1832","P14902","IDO1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","790.604","789.188164084","1.85","52","5","15","6","20","230.87","C32H37BrFN9O9","InChI=1S/C32H37BrFN9O9/c33-21-18-19(4-5-22(21)34)38-29(40-48)27-28(42-52-41-27)37-9-8-35-10-12-49-14-16-51-17-15-50-13-11-36-23-3-1-2-20-26(23)32(47)43(31(20)46)24-6-7-25(44)39-30(24)45/h1-5,18,24,35-36,48H,6-17H2,(H,37,42)(H,38,40)(H,39,44,45)","YGDPNFCJJZXQCF-UHFFFAOYSA-N"
"1833","P14902","IDO1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","34270","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","878.71","877.24059358","1.55","58","5","17","6","26","249.33","C36H45BrFN9O11","InChI=1S/C36H45BrFN9O11/c37-25-22-23(4-5-26(25)38)42-33(44-52)31-32(46-58-45-31)41-9-8-39-10-12-53-14-16-55-18-20-57-21-19-56-17-15-54-13-11-40-27-3-1-2-24-30(27)36(51)47(35(24)50)28-6-7-29(48)43-34(28)49/h1-5,22,28,39-40,52H,6-21H2,(H,41,46)(H,42,44)(H,43,48,49)","YDEQEGICAMJAIK-UHFFFAOYSA-N"
"1834","P14902","IDO1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)=C3C2=O)C(=O)N1","2840","93","Degradation of IDO1 in HeLa cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35380","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","966.816","965.293023076","1.26","64","5","19","6","32","267.79","C40H53BrFN9O13","InChI=1S/C40H53BrFN9O13/c41-29-26-27(4-5-30(29)42)46-37(48-56)35-36(50-64-49-35)45-9-8-43-10-12-57-14-16-59-18-20-61-22-24-63-25-23-62-21-19-60-17-15-58-13-11-44-31-3-1-2-28-34(31)40(55)51(39(28)54)32-6-7-33(52)47-38(32)53/h1-5,26,32,43-44,56H,6-25H2,(H,45,50)(H,46,48)(H,47,52,53)","BVQZWOPTIZSOAW-UHFFFAOYSA-N"
"1835","P14902","IDO1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNCCNC4=NON=C4/C(=N\O)NC4=CC=C(F)C(Br)=C4)=C3C2=O)C(=O)N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","37430","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.02.010","1054.922","1053.34545257","0.96","70","5","21","6","38","286.25","C44H61BrFN9O15","InChI=1S/C44H61BrFN9O15/c45-33-30-31(4-5-34(33)46)50-41(52-60)39-40(54-70-53-39)49-9-8-47-10-12-61-14-16-63-18-20-65-22-24-67-26-28-69-29-27-68-25-23-66-21-19-64-17-15-62-13-11-48-35-3-1-2-32-38(35)44(59)55(43(32)58)36-6-7-37(56)51-42(36)57/h1-5,30,36,47-48,60H,6-29H2,(H,49,54)(H,50,52)(H,51,56,57)","WUUYWUDYFMUNCU-UHFFFAOYSA-N"
"1836","Q06124","SHP2","CRBN","","","CC1(NCC2=CN(CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)CCN(C2=CN=C(C3=CC=CC(Cl)=C3Cl)C(N)=N2)CC1","","","","","","306","Inhibition of SHP2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104788","820.739","819.277483456","2.49","57","7","15","4","16","211.82","C38H43Cl2N11O6","InChI=1S/C38H43Cl2N11O6/c1-38(10-13-49(14-11-38)29-21-43-33(34(41)45-29)25-5-2-6-26(39)32(25)40)44-20-23-22-50(48-47-23)15-17-57-19-18-56-16-12-42-27-7-3-4-24-31(27)37(55)51(36(24)54)28-8-9-30(52)46-35(28)53/h2-7,21-22,28,42,44H,8-20H2,1H3,(H2,41,45)(H,46,52,53)","DNYIHARGRNVSNK-UHFFFAOYSA-N"
"1837","Q06124","SHP2","CRBN","","","CC1(NCC2=CN(CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)CCN(C2=CN=C(C3=CC=CC(Cl)=C3Cl)C(N)=N2)CC1","","","","","","945","Inhibition of SHP2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.77","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104788","864.792","863.303698204","2.34","60","7","16","4","19","221.05","C40H47Cl2N11O7","InChI=1S/C40H47Cl2N11O7/c1-40(10-13-51(14-11-40)31-23-45-35(36(43)47-31)27-5-2-6-28(41)34(27)42)46-22-25-24-52(50-49-25)15-17-59-19-21-60-20-18-58-16-12-44-29-7-3-4-26-33(29)39(57)53(38(26)56)30-8-9-32(54)48-37(30)55/h2-7,23-24,30,44,46H,8-22H2,1H3,(H2,43,47)(H,48,54,55)","PBZGDXXAFHXKFL-UHFFFAOYSA-N"
"1838","Q06124","SHP2","CRBN","","","CC1(NCC2=CN(CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)CCN(C2=CN=C(C3=CC=CC(Cl)=C3Cl)C(N)=N2)CC1","","","","","","714","Inhibition of SHP2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.3","Inhibit viability of HeLa cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104788","908.845","907.329912952","2.19","63","7","17","4","22","230.28","C42H51Cl2N11O8","InChI=1S/C42H51Cl2N11O8/c1-42(10-13-53(14-11-42)33-25-47-37(38(45)49-33)29-5-2-6-30(43)36(29)44)48-24-27-26-54(52-51-27)15-17-61-19-21-63-23-22-62-20-18-60-16-12-46-31-7-3-4-28-35(31)41(59)55(40(28)58)32-8-9-34(56)50-39(32)57/h2-7,25-26,32,46,48H,8-24H2,1H3,(H2,45,49)(H,50,56,57)","PVZCLGQITBYVPH-UHFFFAOYSA-N"
"1839","Q06124","SHP2","CRBN","","","CC1(NCC2=CN(CCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)CCN(C2=CN=C(C3=CC=CC(Cl)=C3Cl)C(N)=N2)CC1","","","","","","1084","Inhibition of SHP2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104788","952.898","951.3561277","2.05","66","7","18","4","25","239.51","C44H55Cl2N11O9","InChI=1S/C44H55Cl2N11O9/c1-44(10-13-55(14-11-44)35-27-49-39(40(47)51-35)31-5-2-6-32(45)38(31)46)50-26-29-28-56(54-53-29)15-17-63-19-21-65-23-25-66-24-22-64-20-18-62-16-12-48-33-7-3-4-30-37(33)43(61)57(42(30)60)34-8-9-36(58)52-41(34)59/h2-7,27-28,34,48,50H,8-26H2,1H3,(H2,47,51)(H,52,58,59)","PYJHMAUHLQLEJR-UHFFFAOYSA-N"
"1840","P35348","ADRA1A","CRBN","","","COC1=CC2=NC(N3CCN(C(=O)C4=CN(CCOCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)=NC(N)=C2C=C1OC","4320","","Degradation of ADRA1A in HEK293 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.01.014","741.722","741.2619217","0.07","54","7","16","3","11","246.4","C34H35N11O9","InChI=1S/C34H35N11O9/c1-52-24-14-19-21(15-25(24)53-2)37-34(39-29(19)35)43-10-8-42(9-11-43)32(50)22-16-44(41-40-22)12-13-54-17-27(47)36-20-5-3-4-18-28(20)33(51)45(31(18)49)23-6-7-26(46)38-30(23)48/h3-5,14-16,23H,6-13,17H2,1-2H3,(H,36,47)(H2,35,37,39)(H,38,46,48)","BMEBWCUDRJFZGZ-UHFFFAOYSA-N"
"1841","P35348","ADRA1A","CRBN","","","COC1=CC2=NC(N3CCN(C(=O)C4=CN(CCOCCOCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)=NC(N)=C2C=C1OC","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.01.014","785.775","785.288136448","-0.08","57","7","17","3","14","255.63","C36H39N11O10","InChI=1S/C36H39N11O10/c1-54-26-16-21-23(17-27(26)55-2)39-36(41-31(21)37)45-10-8-44(9-11-45)34(52)24-18-46(43-42-24)12-13-56-14-15-57-19-29(49)38-22-5-3-4-20-30(22)35(53)47(33(20)51)25-6-7-28(48)40-32(25)50/h3-5,16-18,25H,6-15,19H2,1-2H3,(H,38,49)(H2,37,39,41)(H,40,48,50)","CEVJUFMULVFLBY-UHFFFAOYSA-N"
"1842","P35348","ADRA1A","CRBN","","","COC1=CC2=NC(N3CCN(C(=O)C4=CN(CCOCCOCCOCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)=NC(N)=C2C=C1OC","2860","94","Degradation of ADRA1A in HEK293 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6120","Inhibit proliferation of PC-3 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.01.014","829.828","829.314351196","-0.23","60","7","18","3","17","264.86","C38H43N11O11","InChI=1S/C38H43N11O11/c1-56-28-18-23-25(19-29(28)57-2)41-38(43-33(23)39)47-10-8-46(9-11-47)36(54)26-20-48(45-44-26)12-13-58-14-15-59-16-17-60-21-31(51)40-24-5-3-4-22-32(24)37(55)49(35(22)53)27-6-7-30(50)42-34(27)52/h3-5,18-20,27H,6-17,21H2,1-2H3,(H,40,51)(H2,39,41,43)(H,42,50,52)","SFODRSARUJDQSA-UHFFFAOYSA-N"
"1843","Q13547","HDAC1","CRBN","","","O=C(CCCCCCNC(=O)C1=CC=C(NC(=O)COCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1)NO","","","","","","174","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202006725","738.751","738.286070784","-0.3","53","4","12","6","21","247.87","C35H42N6O12","InChI=1S/C35H42N6O12/c42-27-14-13-25(33(47)39-27)41-34(48)24-6-5-7-26(31(24)35(41)49)53-21-29(44)36-16-17-51-18-19-52-20-30(45)38-23-11-9-22(10-12-23)32(46)37-15-4-2-1-3-8-28(43)40-50/h5-7,9-12,25,50H,1-4,8,13-21H2,(H,36,44)(H,37,46)(H,38,45)(H,40,43)(H,39,42,47)","PTJNYVXLFRBJGN-UHFFFAOYSA-N"
"1843","Q92769","HDAC2","CRBN","","","O=C(CCCCCCNC(=O)C1=CC=C(NC(=O)COCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1)NO","","","","","","248","Inhibition of HDAC2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202006725","738.751","738.286070784","-0.3","53","4","12","6","21","247.87","C35H42N6O12","InChI=1S/C35H42N6O12/c42-27-14-13-25(33(47)39-27)41-34(48)24-6-5-7-26(31(24)35(41)49)53-21-29(44)36-16-17-51-18-19-52-20-30(45)38-23-11-9-22(10-12-23)32(46)37-15-4-2-1-3-8-28(43)40-50/h5-7,9-12,25,50H,1-4,8,13-21H2,(H,36,44)(H,37,46)(H,38,45)(H,40,43)(H,39,42,47)","PTJNYVXLFRBJGN-UHFFFAOYSA-N"
"1843","O15379","HDAC3","CRBN","","","O=C(CCCCCCNC(=O)C1=CC=C(NC(=O)COCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1)NO","","","","","","159","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202006725","738.751","738.286070784","-0.3","53","4","12","6","21","247.87","C35H42N6O12","InChI=1S/C35H42N6O12/c42-27-14-13-25(33(47)39-27)41-34(48)24-6-5-7-26(31(24)35(41)49)53-21-29(44)36-16-17-51-18-19-52-20-30(45)38-23-11-9-22(10-12-23)32(46)37-15-4-2-1-3-8-28(43)40-50/h5-7,9-12,25,50H,1-4,8,13-21H2,(H,36,44)(H,37,46)(H,38,45)(H,40,43)(H,39,42,47)","PTJNYVXLFRBJGN-UHFFFAOYSA-N"
"1843","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCNC(=O)C1=CC=C(NC(=O)COCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1)NO","","","","","","27","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202006725","738.751","738.286070784","-0.3","53","4","12","6","21","247.87","C35H42N6O12","InChI=1S/C35H42N6O12/c42-27-14-13-25(33(47)39-27)41-34(48)24-6-5-7-26(31(24)35(41)49)53-21-29(44)36-16-17-51-18-19-52-20-30(45)38-23-11-9-22(10-12-23)32(46)37-15-4-2-1-3-8-28(43)40-50/h5-7,9-12,25,50H,1-4,8,13-21H2,(H,36,44)(H,37,46)(H,38,45)(H,40,43)(H,39,42,47)","PTJNYVXLFRBJGN-UHFFFAOYSA-N"
"1844","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6840","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","688.686","688.226824592","2.43","50","6","12","1","7","188.75","C36H36N2O12","InChI=1S/C36H36N2O12/c1-19(31(44)48-24-9-5-8-22-27(24)30(43)38(29(22)42)23-10-11-26(40)37-28(23)41)7-6-15-34(3)25-14-17-35(33(46)50-34)16-12-21(32(45)47-4)13-18-36(25,35)49-20(2)39/h5-9,12,15,23,25H,10-11,13-14,16-18H2,1-4H3,(H,37,40,41)/b15-6+,19-7+/t23?,25-,34-,35-,36+/m1/s1","UGAAQMHZRGBKQI-YMRORBOUSA-N"
"1845","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O","13850","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12450","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","718.712","718.237389276","2.64","52","6","13","1","9","197.98","C37H38N2O13","InChI=1S/C37H38N2O13/c1-20(32(45)50-19-49-25-9-5-8-23-28(25)31(44)39(30(23)43)24-10-11-27(41)38-29(24)42)7-6-15-35(3)26-14-17-36(34(47)52-35)16-12-22(33(46)48-4)13-18-37(26,36)51-21(2)40/h5-9,12,15,24,26H,10-11,13-14,16-19H2,1-4H3,(H,38,41,42)/b15-6+,20-7+/t24?,26-,35-,36-,37+/m1/s1","LACKEONNEGURRH-UEKFTLLPSA-N"
"1846","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12100","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","732.739","732.25303934","2.54","53","6","13","1","10","197.98","C38H40N2O13","InChI=1S/C38H40N2O13/c1-21(33(46)51-20-19-50-26-9-5-8-24-29(26)32(45)40(31(24)44)25-10-11-28(42)39-30(25)43)7-6-15-36(3)27-14-17-37(35(48)53-36)16-12-23(34(47)49-4)13-18-38(27,37)52-22(2)41/h5-9,12,15,25,27H,10-11,13-14,16-20H2,1-4H3,(H,39,42,43)/b15-6+,21-7+/t25?,27-,36-,37-,38+/m1/s1","WHUXRYAADPSZDQ-AVBJXDJUSA-N"
"1847","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14140","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","746.766","746.268689404","2.9","54","6","13","1","11","197.98","C39H42N2O13","InChI=1S/C39H42N2O13/c1-22(8-6-16-37(3)28-15-18-38(36(49)54-37)17-13-24(35(48)50-4)14-19-39(28,38)53-23(2)42)34(47)52-21-7-20-51-27-10-5-9-25-30(27)33(46)41(32(25)45)26-11-12-29(43)40-31(26)44/h5-6,8-10,13,16,26,28H,7,11-12,14-15,17-21H2,1-4H3,(H,40,43,44)/b16-6+,22-8+/t26?,28-,37-,38-,39+/m1/s1","YPWCKSJHFDZUNO-XAWXCVTDSA-N"
"1848","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","774.82","774.299989532","3.61","56","6","13","1","13","197.98","C41H46N2O13","InChI=1S/C41H46N2O13/c1-24(10-9-18-39(3)30-17-20-40(38(51)56-39)19-15-26(37(50)52-4)16-21-41(30,40)55-25(2)44)36(49)54-23-7-5-6-22-53-29-12-8-11-27-32(29)35(48)43(34(27)47)28-13-14-31(45)42-33(28)46/h8-12,15,18,28,30H,5-7,13-14,16-17,19-23H2,1-4H3,(H,42,45,46)/b18-9+,24-10+/t28?,30-,39-,40-,41+/m1/s1","NPCDHHICMMZLER-JEIKEVFSSA-N"
"1849","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCCCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">40000","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","802.874","802.33128966","4.51","58","6","13","1","15","197.98","C43H50N2O13","InChI=1S/C43H50N2O13/c1-26(12-11-20-41(3)32-19-22-42(40(53)58-41)21-17-28(39(52)54-4)18-23-43(32,42)57-27(2)46)38(51)56-25-9-7-5-6-8-24-55-31-14-10-13-29-34(31)37(50)45(36(29)49)30-15-16-33(47)44-35(30)48/h10-14,17,20,30,32H,5-9,15-16,18-19,21-25H2,1-4H3,(H,44,47,48)/b20-11+,26-12+/t30?,32-,41-,42-,43+/m1/s1","DHWXVGHEJBGGBG-RKRJGGBXSA-N"
"1850","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCOCCOCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4030","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","820.845","820.305468836","2.25","59","6","15","1","16","216.44","C42H48N2O15","InChI=1S/C42H48N2O15/c1-25(7-6-15-40(3)31-14-17-41(39(52)59-40)16-12-27(38(51)53-4)13-18-42(31,41)58-26(2)45)37(50)57-24-22-55-20-19-54-21-23-56-30-9-5-8-28-33(30)36(49)44(35(28)48)29-10-11-32(46)43-34(29)47/h5-9,12,15,29,31H,10-11,13-14,16-24H2,1-4H3,(H,43,46,47)/b15-6+,25-7+/t29?,31-,40-,41-,42+/m1/s1","LIIPDGRRJYPSAT-CUULVINISA-N"
"1851","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)OCCOCCOCCOCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4460","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","864.898","864.331683584","2.1","62","6","16","1","19","225.67","C44H52N2O16","InChI=1S/C44H52N2O16/c1-27(7-6-15-42(3)33-14-17-43(41(54)62-42)16-12-29(40(53)55-4)13-18-44(33,43)61-28(2)47)39(52)60-26-24-58-22-20-56-19-21-57-23-25-59-32-9-5-8-30-35(32)38(51)46(37(30)50)31-10-11-34(48)45-36(31)49/h5-9,12,15,31,33H,10-11,13-14,16-26H2,1-4H3,(H,45,48,49)/b15-6+,27-7+/t31?,33-,42-,43-,44+/m1/s1","KIKGYQSXBONTRB-SLICWOFJSA-N"
"1852","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O","6720","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6230","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","730.771","730.285008164","2.53","53","6","12","3","10","203.58","C38H42N4O11","InChI=1S/C38H42N4O11/c1-21(30(45)40-20-19-39-25-9-5-8-24-29(25)33(48)42(32(24)47)26-10-11-28(44)41-31(26)46)7-6-15-36(3)27-14-17-37(35(50)53-36)16-12-23(34(49)51-4)13-18-38(27,37)52-22(2)43/h5-9,12,15,26-27,39H,10-11,13-14,16-20H2,1-4H3,(H,40,45)(H,41,44,46)/b15-6+,21-7+/t26?,27-,36-,37-,38+/m1/s1","HXOYUWKUTDAHIM-CIDUFYDMSA-N"
"1853","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)NCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7090","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","744.798","744.300658228","2.89","54","6","12","3","11","203.58","C39H44N4O11","InChI=1S/C39H44N4O11/c1-22(8-6-16-37(3)28-15-18-38(36(51)54-37)17-13-24(35(50)52-4)14-19-39(28,38)53-23(2)44)31(46)41-21-7-20-40-26-10-5-9-25-30(26)34(49)43(33(25)48)27-11-12-29(45)42-32(27)47/h5-6,8-10,13,16,27-28,40H,7,11-12,14-15,17-21H2,1-4H3,(H,41,46)(H,42,45,47)/b16-6+,22-8+/t27?,28-,37-,38-,39+/m1/s1","FINCIBVFPLIQGI-IRTJMNHGSA-N"
"1854","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5430","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","758.825","758.316308292","3.24","55","6","12","3","12","203.58","C40H46N4O11","InChI=1S/C40H46N4O11/c1-23(9-8-17-38(3)29-16-19-39(37(52)55-38)18-14-25(36(51)53-4)15-20-40(29,39)54-24(2)45)32(47)42-22-6-5-21-41-27-11-7-10-26-31(27)35(50)44(34(26)49)28-12-13-30(46)43-33(28)48/h7-11,14,17,28-29,41H,5-6,12-13,15-16,18-22H2,1-4H3,(H,42,47)(H,43,46,48)/b17-8+,23-9+/t28?,29-,38-,39-,40+/m1/s1","MBFRJWUVWQWPIJ-IFHYTNTRSA-N"
"1855","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6230","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","786.879","786.34760842","3.96","57","6","12","3","14","203.58","C42H50N4O11","InChI=1S/C42H50N4O11/c1-25(11-10-19-40(3)31-18-21-41(39(54)57-40)20-16-27(38(53)55-4)17-22-42(31,41)56-26(2)47)34(49)44-24-8-6-5-7-23-43-29-13-9-12-28-33(29)37(52)46(36(28)51)30-14-15-32(48)45-35(30)50/h9-13,16,19,30-31,43H,5-8,14-15,17-18,20-24H2,1-4H3,(H,44,49)(H,45,48,50)/b19-10+,25-11+/t30?,31-,40-,41-,42+/m1/s1","JGEQPCIHUWDGBZ-FDGMJWISSA-N"
"1856","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)N1CCN(C2=CC=CC4=C2C(=O)N(C2CCC(=O)NC2=O)C4=O)CC1)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24970","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","756.809","756.300658228","2.07","55","7","12","1","7","186.0","C40H44N4O11","InChI=1S/C40H44N4O11/c1-23(7-6-15-38(3)29-14-17-39(37(52)55-38)16-12-25(36(51)53-4)13-18-40(29,39)54-24(2)45)33(48)43-21-19-42(20-22-43)27-9-5-8-26-31(27)35(50)44(34(26)49)28-10-11-30(46)41-32(28)47/h5-9,12,15,28-29H,10-11,13-14,16-22H2,1-4H3,(H,41,46,47)/b15-6+,23-7+/t28?,29-,38-,39-,40+/m1/s1","UGEBDJFVWGYGBO-DKBIAIPGSA-N"
"1857","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)NC1CCN(C2=CC=CC4=C2C(=O)N(C2CCC(=O)NC2=O)C4=O)CC1)OC3=O","16840","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4770","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","770.836","770.316308292","2.67","56","7","12","2","8","194.79","C41H46N4O11","InChI=1S/C41H46N4O11/c1-23(7-6-17-39(3)30-14-19-40(38(53)56-39)18-12-25(37(52)54-4)13-20-41(30,40)55-24(2)46)33(48)42-26-15-21-44(22-16-26)28-9-5-8-27-32(28)36(51)45(35(27)50)29-10-11-31(47)43-34(29)49/h5-9,12,17,26,29-30H,10-11,13-16,18-22H2,1-4H3,(H,42,48)(H,43,47,49)/b17-6+,23-7+/t29?,30-,39-,40-,41+/m1/s1","LMIYKUREKRMWNT-ZQUWOFLKSA-N"
"1858","P35613","CD147","CRBN","","","COC(=O)C1=CC[C@]23CC[C@@H]([C@@]2(OC(C)=O)CC1)[C@@](C)(/C=C/C=C(\C)C(=O)N1CCC(NC2=CC=CC4=C2C(=O)N(C2CCC(=O)NC2=O)C4=O)CC1)OC3=O",">40000","","Degradation of CD147 in Sk-Mel-28 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28860","Inhibit proliferation of Sk-Mel-28 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2020.104453","770.836","770.316308292","2.71","56","7","12","2","8","194.79","C41H46N4O11","InChI=1S/C41H46N4O11/c1-23(7-6-17-39(3)30-14-19-40(38(53)56-39)18-12-25(37(52)54-4)13-20-41(30,40)55-24(2)46)34(49)44-21-15-26(16-22-44)42-28-9-5-8-27-32(28)36(51)45(35(27)50)29-10-11-31(47)43-33(29)48/h5-9,12,17,26,29-30,42H,10-11,13-16,18-22H2,1-4H3,(H,43,47,48)/b17-6+,23-7+/t29?,30-,39-,40-,41+/m1/s1","JRWNCELYFXURRI-ZQUWOFLKSA-N"
"1859","O15379","HDAC3","CRBN","","HD-TAC1","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","520","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","639.669","639.244146396","1.68","47","5","9","6","12","208.9","C33H33N7O7","InChI=1S/C33H33N7O7/c34-22-7-1-2-8-23(22)38-30(44)19-11-13-20(14-12-19)37-26(41)10-3-4-17-35-28(43)18-36-24-9-5-6-21-29(24)33(47)40(32(21)46)25-15-16-27(42)39-31(25)45/h1-2,5-9,11-14,25,36H,3-4,10,15-18,34H2,(H,35,43)(H,37,41)(H,38,44)(H,39,42,45)","SRCGSXKCMDYLRX-UHFFFAOYSA-N"
"1860","O15379","HDAC3","CRBN","","HD-TAC2","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","1000","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","582.617","582.22268268","2.34","43","5","8","5","10","179.8","C31H30N6O6","InChI=1S/C31H30N6O6/c32-21-7-1-2-8-22(21)35-28(40)18-11-13-19(14-12-18)34-25(38)10-3-4-17-33-23-9-5-6-20-27(23)31(43)37(30(20)42)24-15-16-26(39)36-29(24)41/h1-2,5-9,11-14,24,33H,3-4,10,15-17,32H2,(H,34,38)(H,35,40)(H,36,39,41)","CDVJLYDZKYPQJI-UHFFFAOYSA-N"
"1861","Q92769","HDAC2","CRBN","","HD-TAC3","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","970","Inhibition of HDAC2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","596.644","596.238332744","2.69","44","5","8","5","11","179.8","C32H32N6O6","InChI=1S/C32H32N6O6/c33-22-8-3-4-9-23(22)36-29(41)19-12-14-20(15-13-19)35-26(39)11-2-1-5-18-34-24-10-6-7-21-28(24)32(44)38(31(21)43)25-16-17-27(40)37-30(25)42/h3-4,6-10,12-15,25,34H,1-2,5,11,16-18,33H2,(H,35,39)(H,36,41)(H,37,40,42)","PZFYWPRLDKIIHM-UHFFFAOYSA-N"
"1862","O15379","HDAC3","CRBN","","HD-TAC4","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","870","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","568.59","568.207032616","1.98","42","5","8","5","9","179.8","C30H28N6O6","InChI=1S/C30H28N6O6/c31-20-6-1-2-7-21(20)34-27(39)17-10-12-18(13-11-17)33-24(37)9-4-16-32-22-8-3-5-19-26(22)30(42)36(29(19)41)23-14-15-25(38)35-28(23)40/h1-3,5-8,10-13,23,32H,4,9,14-16,31H2,(H,33,37)(H,34,39)(H,35,38,40)","JDVCZYIRYRWVJK-UHFFFAOYSA-N"
"1863","Q92769","HDAC2","CRBN","","HD-TAC5","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","750","Inhibition of HDAC2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","653.696","653.25979646","2.04","48","5","9","6","13","208.9","C34H35N7O7","InChI=1S/C34H35N7O7/c35-23-8-3-4-9-24(23)39-31(45)20-12-14-21(15-13-20)38-27(42)11-2-1-5-18-36-29(44)19-37-25-10-6-7-22-30(25)34(48)41(33(22)47)26-16-17-28(43)40-32(26)46/h3-4,6-10,12-15,26,37H,1-2,5,11,16-19,35H2,(H,36,44)(H,38,42)(H,39,45)(H,40,43,46)","CRAUZVPYAMLRRZ-UHFFFAOYSA-N"
"1863","O15379","HDAC3","CRBN","","HD-TAC5","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","330","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","653.696","653.25979646","2.04","48","5","9","6","13","208.9","C34H35N7O7","InChI=1S/C34H35N7O7/c35-23-8-3-4-9-24(23)39-31(45)20-12-14-21(15-13-20)38-27(42)11-2-1-5-18-36-29(44)19-37-25-10-6-7-22-30(25)34(48)41(33(22)47)26-16-17-28(43)40-32(26)46/h3-4,6-10,12-15,26,37H,1-2,5,11,16-19,35H2,(H,36,44)(H,38,42)(H,39,45)(H,40,43,46)","CRAUZVPYAMLRRZ-UHFFFAOYSA-N"
"1864","O15379","HDAC3","CRBN","","HD-TAC6","NC1=CC=CC=C1NC(=O)C1=CC=C(NC(=O)CCCNC(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","560","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112800","625.642","625.228496332","1.32","46","5","9","6","11","208.9","C32H31N7O7","InChI=1S/C32H31N7O7/c33-21-6-1-2-7-22(21)37-29(43)18-10-12-19(13-11-18)36-25(40)9-4-16-34-27(42)17-35-23-8-3-5-20-28(23)32(46)39(31(20)45)24-14-15-26(41)38-30(24)44/h1-3,5-8,10-13,24,35H,4,9,14-17,33H2,(H,34,42)(H,36,40)(H,37,43)(H,38,41,44)","DVHSVOTUIFPGKP-UHFFFAOYSA-N"
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"1941","O00418","EEF2K","CRBN","","","CCN1C(=O)N(CC(=O)NCCCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(=O)C2=CC(C(N)=O)=C(N)N=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112505","719.712","719.266338384","-0.49","52","5","14","5","15","276.98","C33H37N9O10","InChI=1S/C33H37N9O10/c1-2-40-28-19(14-18(27(35)46)26(34)39-28)30(48)41(33(40)51)15-23(44)36-12-5-3-4-6-13-37-24(45)16-52-21-9-7-8-17-25(21)32(50)42(31(17)49)20-10-11-22(43)38-29(20)47/h7-9,14,20H,2-6,10-13,15-16H2,1H3,(H2,34,39)(H2,35,46)(H,36,44)(H,37,45)(H,38,43,47)","DCYFPMYKQKKPEC-UHFFFAOYSA-N"
"1942","O00418","EEF2K","CRBN","","","CCN1C(=O)N(CC(=O)NCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(=O)C2=CC(C(N)=O)=C(N)N=C21","","56.7","Degradation of EEF2K in MDA-MB-231 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112505","707.657","707.229952876","-2.07","51","5","15","5","14","286.21","C31H33N9O11","InChI=1S/C31H33N9O11/c1-2-38-26-17(12-16(25(33)44)24(32)37-26)28(46)39(31(38)49)13-21(42)34-8-10-50-11-9-35-22(43)14-51-19-5-3-4-15-23(19)30(48)40(29(15)47)18-6-7-20(41)36-27(18)45/h3-5,12,18H,2,6-11,13-14H2,1H3,(H2,32,37)(H2,33,44)(H,34,42)(H,35,43)(H,36,41,45)","WEFNUHQNBKXKGD-UHFFFAOYSA-N"
"1943","P35968","VEGFR-2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N3N=C(N)C4=C(C5=CC=CC(NC(=O)NC6=CC=CC(C(C)C)=C6)=C5)C=CC=C43)C(C)(C)C)C=C2)SC=N1","","","","","",">1000","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000","Inhibit proliferation of EA.hy926 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","940.184","939.446551672","7.63","68","7","11","6","16","213.67","C52H61N9O6S","InChI=1S/C52H61N9O6S/c1-31(2)35-13-10-15-37(25-35)56-51(67)57-38-16-11-14-36(26-38)40-17-12-18-41-45(40)48(53)59-61(41)44(64)20-9-7-8-19-43(63)58-47(52(4,5)6)50(66)60-29-39(62)27-42(60)49(65)54-28-33-21-23-34(24-22-33)46-32(3)55-30-68-46/h10-18,21-26,30-31,39,42,47,62H,7-9,19-20,27-29H2,1-6H3,(H2,53,59)(H,54,65)(H,58,63)(H2,56,57,67)/t39-,42+,47-/m1/s1","XCMSXWSOOSQEDL-PDZNDIJHSA-N"
"1944","P35968","VEGFR-2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)N3N=C(N)C4=C(C5=CC=CC(NC(=O)NC6=CC=CC(C(C)C)=C6)=C5)C=CC=C43)C(C)(C)C)C=C2)SC=N1","","","","","","208.2","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32793","Inhibit proliferation of EA.hy926 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","1010.319","1009.52480199","10.34","73","7","11","6","21","213.67","C57H71N9O6S","InChI=1S/C57H71N9O6S/c1-36(2)40-18-15-20-42(30-40)61-56(72)62-43-21-16-19-41(31-43)45-22-17-23-46-50(45)53(58)64-66(46)49(69)25-14-12-10-8-7-9-11-13-24-48(68)63-52(57(4,5)6)55(71)65-34-44(67)32-47(65)54(70)59-33-38-26-28-39(29-27-38)51-37(3)60-35-73-51/h15-23,26-31,35-36,44,47,52,67H,7-14,24-25,32-34H2,1-6H3,(H2,58,64)(H,59,70)(H,63,68)(H2,61,62,72)/t44-,47+,52-/m1/s1","VTPFXZHLKQSXQP-FEDPBZRBSA-N"
"1945","P35968","VEGFR-2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCCCCC(=O)N3N=C(N)C4=C(C5=CC=CC(NC(=O)NC6=CC=CC(C(C)C)=C6)=C5)C=CC=C43)C(C)(C)C)C=C2)SC=N1","","","","","",">1000","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000","Inhibit proliferation of EA.hy926 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","1066.427","1065.58740225","12.5","77","7","11","6","25","213.67","C61H79N9O6S","InChI=1S/C61H79N9O6S/c1-40(2)44-22-19-24-46(34-44)65-60(76)66-47-25-20-23-45(35-47)49-26-21-27-50-54(49)57(62)68-70(50)53(73)29-18-16-14-12-10-8-7-9-11-13-15-17-28-52(72)67-56(61(4,5)6)59(75)69-38-48(71)36-51(69)58(74)63-37-42-30-32-43(33-31-42)55-41(3)64-39-77-55/h19-27,30-35,39-40,48,51,56,71H,7-18,28-29,36-38H2,1-6H3,(H2,62,68)(H,63,74)(H,67,72)(H2,65,66,76)/t48-,51+,56-/m1/s1","OBCUABBSQSEGRO-XVODFSIUSA-N"
"1946","P35968","VEGFR-2","VHL","","","CC1=CC=C(F)C(NC(=O)NC2=CC=C(C3=CC=CC4=C3C(N)=NN4C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=C1","","","","","",">1000","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","133248","Inhibit proliferation of EA.hy926 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","930.12","929.405829732","6.97","67","7","11","6","15","213.67","C50H56FN9O6S","InChI=1S/C50H56FN9O6S/c1-29-14-23-37(51)38(24-29)56-49(66)55-34-21-19-32(20-22-34)36-10-9-11-39-43(36)46(52)58-60(39)42(63)13-8-6-7-12-41(62)57-45(50(3,4)5)48(65)59-27-35(61)25-40(59)47(64)53-26-31-15-17-33(18-16-31)44-30(2)54-28-67-44/h9-11,14-24,28,35,40,45,61H,6-8,12-13,25-27H2,1-5H3,(H2,52,58)(H,53,64)(H,57,62)(H2,55,56,66)/t35-,40+,45-/m1/s1","MLMBGRMBVNUKFH-RIXQQIMYSA-N"
"1947","P35968","VEGFR-2","VHL","","","CC1=CC=C(F)C(NC(=O)NC2=CC=C(C3=CC=CC4=C3C(N)=NN4C(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=C1","","","","","","208.7","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","38650","Inhibit proliferation of EA.hy926 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","1000.255","999.484080052","9.67","72","7","11","6","20","213.67","C55H66FN9O6S","InChI=1S/C55H66FN9O6S/c1-34-19-28-42(56)43(29-34)61-54(71)60-39-26-24-37(25-27-39)41-15-14-16-44-48(41)51(57)63-65(44)47(68)18-13-11-9-7-6-8-10-12-17-46(67)62-50(55(3,4)5)53(70)64-32-40(66)30-45(64)52(69)58-31-36-20-22-38(23-21-36)49-35(2)59-33-72-49/h14-16,19-29,33,40,45,50,66H,6-13,17-18,30-32H2,1-5H3,(H2,57,63)(H,58,69)(H,62,67)(H2,60,61,71)/t40-,45+,50-/m1/s1","YZGNCBAFOZBYKS-SHPBXJAASA-N"
"1948","P35968","VEGFR-2","VHL","","","CC1=CC=C(F)C(NC(=O)NC2=CC=C(C3=CC=CC4=C3C(N)=NN4C(=O)CCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=C1","","","","","","80.4","IC50 was assessed by ADP-Glo Kinase Assay Kit","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112654","1056.363","1055.54668031","11.84","76","7","11","6","24","213.67","C59H74FN9O6S","InChI=1S/C59H74FN9O6S/c1-38-23-32-46(60)47(33-38)65-58(75)64-43-30-28-41(29-31-43)45-19-18-20-48-52(45)55(61)67-69(48)51(72)22-17-15-13-11-9-7-6-8-10-12-14-16-21-50(71)66-54(59(3,4)5)57(74)68-36-44(70)34-49(68)56(73)62-35-40-24-26-42(27-25-40)53-39(2)63-37-76-53/h18-20,23-33,37,44,49,54,70H,6-17,21-22,34-36H2,1-5H3,(H2,61,67)(H,62,73)(H,66,71)(H2,64,65,75)/t44-,49+,54-/m1/s1","HAQNOFVRIRROBH-RVQPDCMISA-N"
"1949","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","705.776","705.302329968","3.19","52","7","11","4","11","187.73","C37H39N9O6","InChI=1S/C37H39N9O6/c1-44(2)34(50)26-20-45(23-7-3-4-8-23)31-25(26)19-40-37(43-31)41-22-13-11-21(12-14-22)32(48)39-18-6-17-38-27-10-5-9-24-30(27)36(52)46(35(24)51)28-15-16-29(47)42-33(28)49/h5,9-14,19-20,23,28,38H,3-4,6-8,15-18H2,1-2H3,(H,39,48)(H,40,41,43)(H,42,47,49)","DHGXOLFIWKPSKY-UHFFFAOYSA-N"
"1949","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","705.776","705.302329968","3.19","52","7","11","4","11","187.73","C37H39N9O6","InChI=1S/C37H39N9O6/c1-44(2)34(50)26-20-45(23-7-3-4-8-23)31-25(26)19-40-37(43-31)41-22-13-11-21(12-14-22)32(48)39-18-6-17-38-27-10-5-9-24-30(27)36(52)46(35(24)51)28-15-16-29(47)42-33(28)49/h5,9-14,19-20,23,28,38H,3-4,6-8,15-18H2,1-2H3,(H,39,48)(H,40,41,43)(H,42,47,49)","DHGXOLFIWKPSKY-UHFFFAOYSA-N"
"1949","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","705.776","705.302329968","3.19","52","7","11","4","11","187.73","C37H39N9O6","InChI=1S/C37H39N9O6/c1-44(2)34(50)26-20-45(23-7-3-4-8-23)31-25(26)19-40-37(43-31)41-22-13-11-21(12-14-22)32(48)39-18-6-17-38-27-10-5-9-24-30(27)36(52)46(35(24)51)28-15-16-29(47)42-33(28)49/h5,9-14,19-20,23,28,38H,3-4,6-8,15-18H2,1-2H3,(H,39,48)(H,40,41,43)(H,42,47,49)","DHGXOLFIWKPSKY-UHFFFAOYSA-N"
"1950","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","719.803","719.317980032","3.55","53","7","11","4","12","187.73","C38H41N9O6","InChI=1S/C38H41N9O6/c1-45(2)35(51)27-21-46(24-8-3-4-9-24)32-26(27)20-41-38(44-32)42-23-14-12-22(13-15-23)33(49)40-19-6-5-18-39-28-11-7-10-25-31(28)37(53)47(36(25)52)29-16-17-30(48)43-34(29)50/h7,10-15,20-21,24,29,39H,3-6,8-9,16-19H2,1-2H3,(H,40,49)(H,41,42,44)(H,43,48,50)","NVDXLFSUAZBOOF-UHFFFAOYSA-N"
"1950","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","719.803","719.317980032","3.55","53","7","11","4","12","187.73","C38H41N9O6","InChI=1S/C38H41N9O6/c1-45(2)35(51)27-21-46(24-8-3-4-9-24)32-26(27)20-41-38(44-32)42-23-14-12-22(13-15-23)33(49)40-19-6-5-18-39-28-11-7-10-25-31(28)37(53)47(36(25)52)29-16-17-30(48)43-34(29)50/h7,10-15,20-21,24,29,39H,3-6,8-9,16-19H2,1-2H3,(H,40,49)(H,41,42,44)(H,43,48,50)","NVDXLFSUAZBOOF-UHFFFAOYSA-N"
"1950","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","719.803","719.317980032","3.55","53","7","11","4","12","187.73","C38H41N9O6","InChI=1S/C38H41N9O6/c1-45(2)35(51)27-21-46(24-8-3-4-9-24)32-26(27)20-41-38(44-32)42-23-14-12-22(13-15-23)33(49)40-19-6-5-18-39-28-11-7-10-25-31(28)37(53)47(36(25)52)29-16-17-30(48)43-34(29)50/h7,10-15,20-21,24,29,39H,3-6,8-9,16-19H2,1-2H3,(H,40,49)(H,41,42,44)(H,43,48,50)","NVDXLFSUAZBOOF-UHFFFAOYSA-N"
"1951","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","733.83","733.333630096","3.9","54","7","11","4","13","187.73","C39H43N9O6","InChI=1S/C39H43N9O6/c1-46(2)36(52)28-22-47(25-9-4-5-10-25)33-27(28)21-42-39(45-33)43-24-15-13-23(14-16-24)34(50)41-20-7-3-6-19-40-29-12-8-11-26-32(29)38(54)48(37(26)53)30-17-18-31(49)44-35(30)51/h8,11-16,21-22,25,30,40H,3-7,9-10,17-20H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)","DAKPWYFPFPRALJ-UHFFFAOYSA-N"
"1951","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","733.83","733.333630096","3.9","54","7","11","4","13","187.73","C39H43N9O6","InChI=1S/C39H43N9O6/c1-46(2)36(52)28-22-47(25-9-4-5-10-25)33-27(28)21-42-39(45-33)43-24-15-13-23(14-16-24)34(50)41-20-7-3-6-19-40-29-12-8-11-26-32(29)38(54)48(37(26)53)30-17-18-31(49)44-35(30)51/h8,11-16,21-22,25,30,40H,3-7,9-10,17-20H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)","DAKPWYFPFPRALJ-UHFFFAOYSA-N"
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"1966","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","736.786","736.29691024","2.12","54","7","12","3","13","194.16","C38H40N8O8","InChI=1S/C38H40N8O8/c1-44(2)35(50)27-21-45(24-6-3-4-7-24)32-26(27)20-40-38(43-32)41-23-12-10-22(11-13-23)33(48)39-16-17-53-18-19-54-29-9-5-8-25-31(29)37(52)46(36(25)51)28-14-15-30(47)42-34(28)49/h5,8-13,20-21,24,28H,3-4,6-7,14-19H2,1-2H3,(H,39,48)(H,40,41,43)(H,42,47,49)","XETDDOQGLBQKQF-UHFFFAOYSA-N"
"1967","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","780.839","780.323124988","1.97","57","7","13","3","16","203.39","C40H44N8O9","InChI=1S/C40H44N8O9/c1-46(2)37(52)29-23-47(26-6-3-4-7-26)34-28(29)22-42-40(45-34)43-25-12-10-24(11-13-25)35(50)41-16-17-55-18-19-56-20-21-57-31-9-5-8-27-33(31)39(54)48(38(27)53)30-14-15-32(49)44-36(30)51/h5,8-13,22-23,26,30H,3-4,6-7,14-21H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)","LKDLYIBGDSMWLI-UHFFFAOYSA-N"
"1967","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","780.839","780.323124988","1.97","57","7","13","3","16","203.39","C40H44N8O9","InChI=1S/C40H44N8O9/c1-46(2)37(52)29-23-47(26-6-3-4-7-26)34-28(29)22-42-40(45-34)43-25-12-10-24(11-13-25)35(50)41-16-17-55-18-19-56-20-21-57-31-9-5-8-27-33(31)39(54)48(38(27)53)30-14-15-32(49)44-36(30)51/h5,8-13,22-23,26,30H,3-4,6-7,14-21H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)","LKDLYIBGDSMWLI-UHFFFAOYSA-N"
"1967","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","780.839","780.323124988","1.97","57","7","13","3","16","203.39","C40H44N8O9","InChI=1S/C40H44N8O9/c1-46(2)37(52)29-23-47(26-6-3-4-7-26)34-28(29)22-42-40(45-34)43-25-12-10-24(11-13-25)35(50)41-16-17-55-18-19-56-20-21-57-31-9-5-8-27-33(31)39(54)48(38(27)53)30-14-15-32(49)44-36(30)51/h5,8-13,22-23,26,30H,3-4,6-7,14-21H2,1-2H3,(H,41,50)(H,42,43,45)(H,44,49,51)","LKDLYIBGDSMWLI-UHFFFAOYSA-N"
"1968","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","779.855","779.3391094","2.54","57","7","13","4","16","206.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-47(2)37(53)29-23-48(26-6-3-4-7-26)34-28(29)22-43-40(46-34)44-25-12-10-24(11-13-25)35(51)42-17-19-57-21-20-56-18-16-41-30-9-5-8-27-33(30)39(55)49(38(27)54)31-14-15-32(50)45-36(31)52/h5,8-13,22-23,26,31,41H,3-4,6-7,14-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","SFIDPNAUQKASJV-UHFFFAOYSA-N"
"1968","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","779.855","779.3391094","2.54","57","7","13","4","16","206.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-47(2)37(53)29-23-48(26-6-3-4-7-26)34-28(29)22-43-40(46-34)44-25-12-10-24(11-13-25)35(51)42-17-19-57-21-20-56-18-16-41-30-9-5-8-27-33(30)39(55)49(38(27)54)31-14-15-32(50)45-36(31)52/h5,8-13,22-23,26,31,41H,3-4,6-7,14-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","SFIDPNAUQKASJV-UHFFFAOYSA-N"
"1968","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","779.855","779.3391094","2.54","57","7","13","4","16","206.19","C40H45N9O8","InChI=1S/C40H45N9O8/c1-47(2)37(53)29-23-48(26-6-3-4-7-26)34-28(29)22-43-40(46-34)44-25-12-10-24(11-13-25)35(51)42-17-19-57-21-20-56-18-16-41-30-9-5-8-27-33(30)39(55)49(38(27)54)31-14-15-32(50)45-36(31)52/h5,8-13,22-23,26,31,41H,3-4,6-7,14-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","SFIDPNAUQKASJV-UHFFFAOYSA-N"
"1969","P24941","CDK2","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","97.6/165.9","Inhibit proliferation of B16F10/A375 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","747.857","747.34928016","4.26","55","7","11","4","14","187.73","C40H45N9O6","InChI=1S/C40H45N9O6/c1-47(2)37(53)29-23-48(26-10-5-6-11-26)34-28(29)22-43-40(46-34)44-25-16-14-24(15-17-25)35(51)42-21-8-4-3-7-20-41-30-13-9-12-27-33(30)39(55)49(38(27)54)31-18-19-32(50)45-36(31)52/h9,12-17,22-23,26,31,41H,3-8,10-11,18-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","RPVDFNXGQJRZPG-UHFFFAOYSA-N"
"1969","P11802","CDK4","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","97.6/165.9","Inhibit proliferation of B16F10/A375 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","747.857","747.34928016","4.26","55","7","11","4","14","187.73","C40H45N9O6","InChI=1S/C40H45N9O6/c1-47(2)37(53)29-23-48(26-10-5-6-11-26)34-28(29)22-43-40(46-34)44-25-16-14-24(15-17-25)35(51)42-21-8-4-3-7-20-41-30-13-9-12-27-33(30)39(55)49(38(27)54)31-18-19-32(50)45-36(31)52/h9,12-17,22-23,26,31,41H,3-8,10-11,18-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","RPVDFNXGQJRZPG-UHFFFAOYSA-N"
"1969","Q00534","CDK6","CRBN","","","CN(C)C(=O)C1=CN(C2CCCC2)C2=NC(NC3=CC=C(C(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","97.6/165.9","Inhibit proliferation of B16F10/A375 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112903","747.857","747.34928016","4.26","55","7","11","4","14","187.73","C40H45N9O6","InChI=1S/C40H45N9O6/c1-47(2)37(53)29-23-48(26-10-5-6-11-26)34-28(29)22-43-40(46-34)44-25-16-14-24(15-17-25)35(51)42-21-8-4-3-7-20-41-30-13-9-12-27-33(30)39(55)49(38(27)54)31-18-19-32(50)45-36(31)52/h9,12-17,22-23,26,31,41H,3-8,10-11,18-21H2,1-2H3,(H,42,51)(H,43,44,46)(H,45,50,52)","RPVDFNXGQJRZPG-UHFFFAOYSA-N"
"1970","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","19.3","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","956.567","955.381758496","7.28","67","7","14","5","19","221.13","C48H58ClN9O8S","InChI=1S/C48H58ClN9O8S/c1-28(2)66-39-26-33(30(5)25-37(39)54-48-52-27-34(49)44(56-48)53-35-12-6-7-14-40(35)67(64,65)29(3)4)31-17-22-57(23-18-31)24-19-41(59)51-21-9-8-20-50-36-13-10-11-32-43(36)47(63)58(46(32)62)38-15-16-42(60)55-45(38)61/h6-7,10-14,25-29,31,38,50H,8-9,15-24H2,1-5H3,(H,51,59)(H,55,60,61)(H2,52,53,54,56)","WTWFKTBGRXTKGS-UHFFFAOYSA-N"
"1971","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","15.8","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","984.621","983.413058624","7.99","69","7","14","5","21","221.13","C50H62ClN9O8S","InChI=1S/C50H62ClN9O8S/c1-30(2)68-41-28-35(32(5)27-39(41)56-50-54-29-36(51)46(58-50)55-37-14-8-9-16-42(37)69(66,67)31(3)4)33-19-24-59(25-20-33)26-21-43(61)53-23-11-7-6-10-22-52-38-15-12-13-34-45(38)49(65)60(48(34)64)40-17-18-44(62)57-47(40)63/h8-9,12-16,27-31,33,40,52H,6-7,10-11,17-26H2,1-5H3,(H,53,61)(H,57,62,63)(H2,54,55,56,58)","FYKNFKLDEYWTTI-UHFFFAOYSA-N"
"1972","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","19.8","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1012.675","1011.44435875","9.08","71","7","14","5","23","221.13","C52H66ClN9O8S","InChI=1S/C52H66ClN9O8S/c1-32(2)70-43-30-37(34(5)29-41(43)58-52-56-31-38(53)48(60-52)57-39-16-10-11-18-44(39)71(68,69)33(3)4)35-21-26-61(27-22-35)28-23-45(63)55-25-13-9-7-6-8-12-24-54-40-17-14-15-36-47(40)51(67)62(50(36)66)42-19-20-46(64)59-49(42)65/h10-11,14-18,29-33,35,42,54H,6-9,12-13,19-28H2,1-5H3,(H,55,63)(H,59,64,65)(H2,56,57,58,60)","XRPHCGDUUIKCQP-UHFFFAOYSA-N"
"1973","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","10.2","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/5000/4570","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","972.566","971.376673116","6.42","68","7","15","5","20","230.36","C48H58ClN9O9S","InChI=1S/C48H58ClN9O9S/c1-28(2)67-39-26-33(30(5)25-37(39)54-48-52-27-34(49)44(56-48)53-35-10-6-7-12-40(35)68(64,65)29(3)4)31-15-20-57(21-16-31)22-17-41(59)51-19-24-66-23-18-50-36-11-8-9-32-43(36)47(63)58(46(32)62)38-13-14-42(60)55-45(38)61/h6-12,25-29,31,38,50H,13-24H2,1-5H3,(H,51,59)(H,55,60,61)(H2,52,53,54,56)","WATIOPHMVCWMDU-UHFFFAOYSA-N"
"1974","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","2.3","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","700/2600/2230","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1016.619","1015.40288786","6.27","71","7","16","5","23","239.59","C50H62ClN9O10S","InChI=1S/C50H62ClN9O10S/c1-30(2)70-41-28-35(32(5)27-39(41)56-50-54-29-36(51)46(58-50)55-37-10-6-7-12-42(37)71(66,67)31(3)4)33-15-20-59(21-16-33)22-17-43(61)53-19-24-69-26-25-68-23-18-52-38-11-8-9-34-45(38)49(65)60(48(34)64)40-13-14-44(62)57-47(40)63/h6-12,27-31,33,40,52H,13-26H2,1-5H3,(H,53,61)(H,57,62,63)(H2,54,55,56,58)","NJKOJIFQSVZCTA-UHFFFAOYSA-N"
"1975","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.6","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","300/1600/1180","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1060.672","1059.42910261","6.12","74","7","17","5","26","248.82","C52H66ClN9O11S","InChI=1S/C52H66ClN9O11S/c1-32(2)73-43-30-37(34(5)29-41(43)58-52-56-31-38(53)48(60-52)57-39-10-6-7-12-44(39)74(68,69)33(3)4)35-15-20-61(21-16-35)22-17-45(63)55-19-24-71-26-28-72-27-25-70-23-18-54-40-11-8-9-36-47(40)51(67)62(50(36)66)42-13-14-46(64)59-49(42)65/h6-12,29-33,35,42,54H,13-28H2,1-5H3,(H,55,63)(H,59,64,65)(H2,56,57,58,60)","ZOPCYCAHBPUJFX-UHFFFAOYSA-N"
"1976","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","11.4","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8370/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1104.725","1103.45531736","5.98","77","7","18","5","29","258.05","C54H70ClN9O12S","InChI=1S/C54H70ClN9O12S/c1-34(2)76-45-32-39(36(5)31-43(45)60-54-58-33-40(55)50(62-54)59-41-10-6-7-12-46(41)77(70,71)35(3)4)37-15-20-63(21-16-37)22-17-47(65)57-19-24-73-26-28-75-30-29-74-27-25-72-23-18-56-42-11-8-9-38-49(42)53(69)64(52(38)68)44-13-14-48(66)61-51(44)67/h6-12,31-35,37,44,56H,13-30H2,1-5H3,(H,57,65)(H,61,66,67)(H2,58,59,60,62)","AQXDJARBSWYYTB-UHFFFAOYSA-N"
"1977","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","8.3","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3520/13380/8150","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1013.619","1012.40322221","6.07","71","7","15","6","21","250.23","C50H61ClN10O9S","InChI=1S/C50H61ClN10O9S/c1-29(2)70-40-26-34(31(5)25-38(40)57-50-54-27-35(51)46(59-50)56-36-12-6-7-14-41(36)71(68,69)30(3)4)32-17-22-60(23-18-32)24-19-42(62)53-21-9-8-20-52-28-44(64)55-37-13-10-11-33-45(37)49(67)61(48(33)66)39-15-16-43(63)58-47(39)65/h6-7,10-14,25-27,29-30,32,39,52H,8-9,15-24,28H2,1-5H3,(H,53,62)(H,55,64)(H,58,63,65)(H2,54,56,57,59)","XFOUZMHZPQENDL-UHFFFAOYSA-N"
"1978","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","50.9","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100/5130/4360","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1041.673","1040.43452234","6.79","73","7","15","6","23","250.23","C52H65ClN10O9S","InChI=1S/C52H65ClN10O9S/c1-31(2)72-42-28-36(33(5)27-40(42)59-52-56-29-37(53)48(61-52)58-38-14-8-9-16-43(38)73(70,71)32(3)4)34-19-24-62(25-20-34)26-21-44(64)55-23-11-7-6-10-22-54-30-46(66)57-39-15-12-13-35-47(39)51(69)63(50(35)68)41-17-18-45(65)60-49(41)67/h8-9,12-16,27-29,31-32,34,41,54H,6-7,10-11,17-26,30H2,1-5H3,(H,55,64)(H,57,66)(H,60,65,67)(H2,56,58,59,61)","HGTGIKXPFPUHAE-UHFFFAOYSA-N"
"1979","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","12.8","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2660/>20000/7670","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1069.727","1068.46582247","7.87","75","7","15","6","25","250.23","C54H69ClN10O9S","InChI=1S/C54H69ClN10O9S/c1-33(2)74-44-30-38(35(5)29-42(44)61-54-58-31-39(55)50(63-54)60-40-16-10-11-18-45(40)75(72,73)34(3)4)36-21-26-64(27-22-36)28-23-46(66)57-25-13-9-7-6-8-12-24-56-32-48(68)59-41-17-14-15-37-49(41)53(71)65(52(37)70)43-19-20-47(67)62-51(43)69/h10-11,14-18,29-31,33-34,36,43,56H,6-9,12-13,19-28,32H2,1-5H3,(H,57,66)(H,59,68)(H,62,67,69)(H2,58,60,61,63)","ATCFOXIBVDCOLC-UHFFFAOYSA-N"
"1980","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","4.6","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1830/6730/5780","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1029.618","1028.39813683","5.21","72","7","16","6","22","259.46","C50H61ClN10O10S","InChI=1S/C50H61ClN10O10S/c1-29(2)71-40-26-34(31(5)25-38(40)57-50-54-27-35(51)46(59-50)56-36-10-6-7-12-41(36)72(68,69)30(3)4)32-15-20-60(21-16-32)22-17-42(62)53-19-24-70-23-18-52-28-44(64)55-37-11-8-9-33-45(37)49(67)61(48(33)66)39-13-14-43(63)58-47(39)65/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,53,62)(H,55,64)(H,58,63,65)(H2,54,56,57,59)","AFWZDQCYCBFHOB-UHFFFAOYSA-N"
"1981","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","4.8","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2340/5810/5860","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1073.671","1072.42435158","5.07","75","7","17","6","25","268.69","C52H65ClN10O11S","InChI=1S/C52H65ClN10O11S/c1-31(2)74-42-28-36(33(5)27-40(42)59-52-56-29-37(53)48(61-52)58-38-10-6-7-12-43(38)75(70,71)32(3)4)34-15-20-62(21-16-34)22-17-44(64)55-19-24-73-26-25-72-23-18-54-30-46(66)57-39-11-8-9-35-47(39)51(69)63(50(35)68)41-13-14-45(65)60-49(41)67/h6-12,27-29,31-32,34,41,54H,13-26,30H2,1-5H3,(H,55,64)(H,57,66)(H,60,65,67)(H2,56,58,59,61)","OOLZSXPEPPATOF-UHFFFAOYSA-N"
"1982","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCOCCNCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","5.4","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/12210","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1117.724","1116.45056633","4.92","78","7","18","6","28","277.92","C54H69ClN10O12S","InChI=1S/C54H69ClN10O12S/c1-33(2)77-44-30-38(35(5)29-42(44)61-54-58-31-39(55)50(63-54)60-40-10-6-7-12-45(40)78(72,73)34(3)4)36-15-20-64(21-16-36)22-17-46(66)57-19-24-75-26-28-76-27-25-74-23-18-56-32-48(68)59-41-11-8-9-37-49(41)53(71)65(52(37)70)43-13-14-47(67)62-51(43)69/h6-12,29-31,33-34,36,43,56H,13-28,32H2,1-5H3,(H,57,66)(H,59,68)(H,62,67,69)(H2,58,60,61,63)","LIOVQOVBTZMJAW-UHFFFAOYSA-N"
"1983","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCNCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.5","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/14340/9050","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1027.646","1026.41887228","5.98","72","7","15","6","22","250.23","C51H63ClN10O9S","InChI=1S/C51H63ClN10O9S/c1-30(2)71-41-28-35(32(5)27-39(41)58-51-55-29-36(52)47(60-51)57-37-12-6-7-14-42(37)72(69,70)31(3)4)33-18-24-61(25-19-33)26-20-43(63)54-22-9-8-21-53-23-17-45(65)56-38-13-10-11-34-46(38)50(68)62(49(34)67)40-15-16-44(64)59-48(40)66/h6-7,10-14,27-31,33,40,53H,8-9,15-26H2,1-5H3,(H,54,63)(H,56,65)(H,59,64,66)(H2,55,57,58,60)","ZDDSPYQXQMXKQZ-UHFFFAOYSA-N"
"1984","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCNCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","12.6","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1055.7","1054.4501724","6.69","74","7","15","6","24","250.23","C53H67ClN10O9S","InChI=1S/C53H67ClN10O9S/c1-32(2)73-43-30-37(34(5)29-41(43)60-53-57-31-38(54)49(62-53)59-39-14-8-9-16-44(39)74(71,72)33(3)4)35-20-26-63(27-21-35)28-22-45(65)56-24-11-7-6-10-23-55-25-19-47(67)58-40-15-12-13-36-48(40)52(70)64(51(36)69)42-17-18-46(66)61-50(42)68/h8-9,12-16,29-33,35,42,55H,6-7,10-11,17-28H2,1-5H3,(H,56,65)(H,58,67)(H,61,66,68)(H2,57,59,60,62)","QCNJMGWMJCZUNY-UHFFFAOYSA-N"
"1985","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCNCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.4","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4860/10900/7980","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1043.645","1042.4137869","5.12","73","7","16","6","23","259.46","C51H63ClN10O10S","InChI=1S/C51H63ClN10O10S/c1-30(2)72-41-28-35(32(5)27-39(41)58-51-55-29-36(52)47(60-51)57-37-10-6-7-12-42(37)73(69,70)31(3)4)33-16-22-61(23-17-33)24-18-43(63)54-21-26-71-25-20-53-19-15-45(65)56-38-11-8-9-34-46(38)50(68)62(49(34)67)40-13-14-44(64)59-48(40)66/h6-12,27-31,33,40,53H,13-26H2,1-5H3,(H,54,63)(H,56,65)(H,59,64,66)(H2,55,57,58,60)","GOMBJIHJBAGEMJ-UHFFFAOYSA-N"
"1986","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCNCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.9","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/6010/5520","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1087.698","1086.44000164","4.97","76","7","17","6","26","268.69","C53H67ClN10O11S","InChI=1S/C53H67ClN10O11S/c1-32(2)75-43-30-37(34(5)29-41(43)60-53-57-31-38(54)49(62-53)59-39-10-6-7-12-44(39)76(71,72)33(3)4)35-16-22-63(23-17-35)24-18-45(65)56-21-26-74-28-27-73-25-20-55-19-15-47(67)58-40-11-8-9-36-48(40)52(70)64(51(36)69)42-13-14-46(66)61-50(42)68/h6-12,29-33,35,42,55H,13-28H2,1-5H3,(H,56,65)(H,58,67)(H,61,66,68)(H2,57,59,60,62)","ONEASCOZANGQFF-UHFFFAOYSA-N"
"1987","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","15.8","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1300/>20000/6990","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1014.603","1013.3872378","6.06","71","7","15","5","21","247.43","C50H60ClN9O10S","InChI=1S/C50H60ClN9O10S/c1-29(2)70-40-26-34(31(5)25-37(40)56-50-54-27-35(51)46(58-50)55-36-12-6-7-14-41(36)71(67,68)30(3)4)32-17-22-59(23-18-32)24-19-42(61)52-20-8-9-21-53-44(63)28-69-39-13-10-11-33-45(39)49(66)60(48(33)65)38-15-16-43(62)57-47(38)64/h6-7,10-14,25-27,29-30,32,38H,8-9,15-24,28H2,1-5H3,(H,52,61)(H,53,63)(H,57,62,64)(H2,54,55,56,58)","HAZNCQBWQOMJMN-UHFFFAOYSA-N"
"1988","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","2.1","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/4660/3870","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1042.657","1041.41853793","6.78","73","7","15","5","23","247.43","C52H64ClN9O10S","InChI=1S/C52H64ClN9O10S/c1-31(2)72-42-28-36(33(5)27-39(42)58-52-56-29-37(53)48(60-52)57-38-14-8-9-16-43(38)73(69,70)32(3)4)34-19-24-61(25-20-34)26-21-44(63)54-22-10-6-7-11-23-55-46(65)30-71-41-15-12-13-35-47(41)51(68)62(50(35)67)40-17-18-45(64)59-49(40)66/h8-9,12-16,27-29,31-32,34,40H,6-7,10-11,17-26,30H2,1-5H3,(H,54,63)(H,55,65)(H,59,64,66)(H2,56,57,58,60)","QCPQCHDYVMUQOG-UHFFFAOYSA-N"
"1989","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCCCCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","5.4","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1070.711","1069.44983806","7.86","75","7","15","5","25","247.43","C54H68ClN9O10S","InChI=1S/C54H68ClN9O10S/c1-33(2)74-44-30-38(35(5)29-41(44)60-54-58-31-39(55)50(62-54)59-40-16-10-11-18-45(40)75(71,72)34(3)4)36-21-26-63(27-22-36)28-23-46(65)56-24-12-8-6-7-9-13-25-57-48(67)32-73-43-17-14-15-37-49(43)53(70)64(52(37)69)42-19-20-47(66)61-51(42)68/h10-11,14-18,29-31,33-34,36,42H,6-9,12-13,19-28,32H2,1-5H3,(H,56,65)(H,57,67)(H,61,66,68)(H2,58,59,60,62)","LBODRFWJLBNQFY-UHFFFAOYSA-N"
"1990","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","3.6","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5410/>20000/7940","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1030.602","1029.38215242","5.2","72","7","16","5","22","256.66","C50H60ClN9O11S","InChI=1S/C50H60ClN9O11S/c1-29(2)71-40-26-34(31(5)25-37(40)56-50-54-27-35(51)46(58-50)55-36-10-6-7-12-41(36)72(67,68)30(3)4)32-15-20-59(21-16-32)22-17-42(61)52-18-23-69-24-19-53-44(63)28-70-39-11-8-9-33-45(39)49(66)60(48(33)65)38-13-14-43(62)57-47(38)64/h6-12,25-27,29-30,32,38H,13-24,28H2,1-5H3,(H,52,61)(H,53,63)(H,57,62,64)(H2,54,55,56,58)","NOLCYPGBPCICKH-UHFFFAOYSA-N"
"1991","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.9","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1074.655","1073.40836717","5.05","75","7","17","5","25","265.89","C52H64ClN9O12S","InChI=1S/C52H64ClN9O12S/c1-31(2)74-42-28-36(33(5)27-39(42)58-52-56-29-37(53)48(60-52)57-38-10-6-7-12-43(38)75(69,70)32(3)4)34-15-20-61(21-16-34)22-17-44(63)54-18-23-71-25-26-72-24-19-55-46(65)30-73-41-11-8-9-35-47(41)51(68)62(50(35)67)40-13-14-45(64)59-49(40)66/h6-12,27-29,31-32,34,40H,13-26,30H2,1-5H3,(H,54,63)(H,55,65)(H,59,64,66)(H2,56,57,58,60)","JPVFWDNAZUDPBW-UHFFFAOYSA-N"
"1992","Q9UM73","ALK","CRBN","","","CC1=CC(NC2=NC=C(Cl)C(NC3=CC=CC=C3S(=O)(=O)C(C)C)=N2)=C(OC(C)C)C=C1C1CCN(CCC(=O)NCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","1.5","IC50 was assessed by mobility shift assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">20000/>20000/>20000","Inhibit proliferation of H3122/A549/HeLa cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.113150","1118.708","1117.43458192","4.9","78","7","18","5","28","275.12","C54H68ClN9O13S","InChI=1S/C54H68ClN9O13S/c1-33(2)77-44-30-38(35(5)29-41(44)60-54-58-31-39(55)50(62-54)59-40-10-6-7-12-45(40)78(71,72)34(3)4)36-15-20-63(21-16-36)22-17-46(65)56-18-23-73-25-27-75-28-26-74-24-19-57-48(67)32-76-43-11-8-9-37-49(43)53(70)64(52(37)69)42-13-14-47(66)61-51(42)68/h6-12,29-31,33-34,36,42H,13-28,32H2,1-5H3,(H,56,65)(H,57,67)(H,61,66,68)(H2,58,59,60,62)","HSAJEOKOQMBEGM-UHFFFAOYSA-N"
"1993","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","220","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","824.003","823.428199176","5.59","61","9","12","4","15","169.72","C46H53N11O4","InChI=1S/C46H53N11O4/c58-40(50-37-16-10-15-35-36(37)30-56(44(35)61)39-22-23-41(59)52-43(39)60)17-6-1-2-9-24-54-25-27-55(28-26-54)33-20-18-32(19-21-33)48-45-47-29-38-42(53-45)57(34-13-7-8-14-34)46(51-38)49-31-11-4-3-5-12-31/h3-5,10-12,15-16,18-21,29,34,39H,1-2,6-9,13-14,17,22-28,30H2,(H,49,51)(H,50,58)(H,47,48,53)(H,52,59,60)","WHKCGHLFWIJUOU-UHFFFAOYSA-N"
"1993","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9301","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","824.003","823.428199176","5.59","61","9","12","4","15","169.72","C46H53N11O4","InChI=1S/C46H53N11O4/c58-40(50-37-16-10-15-35-36(37)30-56(44(35)61)39-22-23-41(59)52-43(39)60)17-6-1-2-9-24-54-25-27-55(28-26-54)33-20-18-32(19-21-33)48-45-47-29-38-42(53-45)57(34-13-7-8-14-34)46(51-38)49-31-11-4-3-5-12-31/h3-5,10-12,15-16,18-21,29,34,39H,1-2,6-9,13-14,17,22-28,30H2,(H,49,51)(H,50,58)(H,47,48,53)(H,52,59,60)","WHKCGHLFWIJUOU-UHFFFAOYSA-N"
"1993","P00533","EGFR e19d","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.41","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","824.003","823.428199176","5.59","61","9","12","4","15","169.72","C46H53N11O4","InChI=1S/C46H53N11O4/c58-40(50-37-16-10-15-35-36(37)30-56(44(35)61)39-22-23-41(59)52-43(39)60)17-6-1-2-9-24-54-25-27-55(28-26-54)33-20-18-32(19-21-33)48-45-47-29-38-42(53-45)57(34-13-7-8-14-34)46(51-38)49-31-11-4-3-5-12-31/h3-5,10-12,15-16,18-21,29,34,39H,1-2,6-9,13-14,17,22-28,30H2,(H,49,51)(H,50,58)(H,47,48,53)(H,52,59,60)","WHKCGHLFWIJUOU-UHFFFAOYSA-N"
"1994","P00533","EGFR","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","240","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","838.03","837.44384924","6.13","62","9","12","4","16","169.72","C47H55N11O4","InChI=1S/C47H55N11O4/c59-41(51-38-17-11-16-36-37(38)31-57(45(36)62)40-23-24-42(60)53-44(40)61)18-7-2-1-3-10-25-55-26-28-56(29-27-55)34-21-19-33(20-22-34)49-46-48-30-39-43(54-46)58(35-14-8-9-15-35)47(52-39)50-32-12-5-4-6-13-32/h4-6,11-13,16-17,19-22,30,35,40H,1-3,7-10,14-15,18,23-29,31H2,(H,50,52)(H,51,59)(H,48,49,54)(H,53,60,61)","TWTFDTRUNNZWOY-UHFFFAOYSA-N"
"1994","P00533","EGFR L858R/T790M","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3776","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","838.03","837.44384924","6.13","62","9","12","4","16","169.72","C47H55N11O4","InChI=1S/C47H55N11O4/c59-41(51-38-17-11-16-36-37(38)31-57(45(36)62)40-23-24-42(60)53-44(40)61)18-7-2-1-3-10-25-55-26-28-56(29-27-55)34-21-19-33(20-22-34)49-46-48-30-39-43(54-46)58(35-14-8-9-15-35)47(52-39)50-32-12-5-4-6-13-32/h4-6,11-13,16-17,19-22,30,35,40H,1-3,7-10,14-15,18,23-29,31H2,(H,50,52)(H,51,59)(H,48,49,54)(H,53,60,61)","TWTFDTRUNNZWOY-UHFFFAOYSA-N"
"1994","P00533","EGFR e19d","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCN4CCN(C5=CC=C(NC6=NC=C7N=C(NC8=CC=CC=C8)N(C8CCCC8)C7=N6)C=C5)CC4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.61","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","838.03","837.44384924","6.13","62","9","12","4","16","169.72","C47H55N11O4","InChI=1S/C47H55N11O4/c59-41(51-38-17-11-16-36-37(38)31-57(45(36)62)40-23-24-42(60)53-44(40)61)18-7-2-1-3-10-25-55-26-28-56(29-27-55)34-21-19-33(20-22-34)49-46-48-30-39-43(54-46)58(35-14-8-9-15-35)47(52-39)50-32-12-5-4-6-13-32/h4-6,11-13,16-17,19-22,30,35,40H,1-3,7-10,14-15,18,23-29,31H2,(H,50,52)(H,51,59)(H,48,49,54)(H,53,60,61)","TWTFDTRUNNZWOY-UHFFFAOYSA-N"
"1995","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","245","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","995.312","994.53636972","8.54","72","9","14","5","19","185.77","C55H70N12O4S","InChI=1S/C55H70N12O4S/c1-37-48(72-36-58-37)39-21-19-38(20-22-39)33-56-51(70)46-32-44(68)35-66(46)52(71)49(55(2,3)4)62-47(69)18-10-5-6-13-27-64-28-30-65(31-29-64)42-25-23-41(24-26-42)59-53-57-34-45-50(63-53)67(43-16-11-12-17-43)54(61-45)60-40-14-8-7-9-15-40/h7-9,14-15,19-26,34,36,43-44,46,49,68H,5-6,10-13,16-18,27-33,35H2,1-4H3,(H,56,70)(H,60,61)(H,62,69)(H,57,59,63)/t44-,46+,49-/m1/s1","MCPFQJKJCFMAIH-CRHSMECVSA-N"
"1995","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","126.2","90.3","Degradation of EGFR L858R/T790M in H1975 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","203","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","995.312","994.53636972","8.54","72","9","14","5","19","185.77","C55H70N12O4S","InChI=1S/C55H70N12O4S/c1-37-48(72-36-58-37)39-21-19-38(20-22-39)33-56-51(70)46-32-44(68)35-66(46)52(71)49(55(2,3)4)62-47(69)18-10-5-6-13-27-64-28-30-65(31-29-64)42-25-23-41(24-26-42)59-53-57-34-45-50(63-53)67(43-16-11-12-17-43)54(61-45)60-40-14-8-7-9-15-40/h7-9,14-15,19-26,34,36,43-44,46,49,68H,5-6,10-13,16-18,27-33,35H2,1-4H3,(H,56,70)(H,60,61)(H,62,69)(H,57,59,63)/t44-,46+,49-/m1/s1","MCPFQJKJCFMAIH-CRHSMECVSA-N"
"1995","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","0.51","80.4","Degradation of EGFR del19 in HCC827 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.83","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","995.312","994.53636972","8.54","72","9","14","5","19","185.77","C55H70N12O4S","InChI=1S/C55H70N12O4S/c1-37-48(72-36-58-37)39-21-19-38(20-22-39)33-56-51(70)46-32-44(68)35-66(46)52(71)49(55(2,3)4)62-47(69)18-10-5-6-13-27-64-28-30-65(31-29-64)42-25-23-41(24-26-42)59-53-57-34-45-50(63-53)67(43-16-11-12-17-43)54(61-45)60-40-14-8-7-9-15-40/h7-9,14-15,19-26,34,36,43-44,46,49,68H,5-6,10-13,16-18,27-33,35H2,1-4H3,(H,56,70)(H,60,61)(H,62,69)(H,57,59,63)/t44-,46+,49-/m1/s1","MCPFQJKJCFMAIH-CRHSMECVSA-N"
"1996","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","330","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1009.339","1008.55201978","9.08","73","9","14","5","20","185.77","C56H72N12O4S","InChI=1S/C56H72N12O4S/c1-38-49(73-37-59-38)40-22-20-39(21-23-40)34-57-52(71)47-33-45(69)36-67(47)53(72)50(56(2,3)4)63-48(70)19-11-6-5-7-14-28-65-29-31-66(32-30-65)43-26-24-42(25-27-43)60-54-58-35-46-51(64-54)68(44-17-12-13-18-44)55(62-46)61-41-15-9-8-10-16-41/h8-10,15-16,20-27,35,37,44-45,47,50,69H,5-7,11-14,17-19,28-34,36H2,1-4H3,(H,57,71)(H,61,62)(H,63,70)(H,58,60,64)/t45-,47+,50-/m1/s1","OAEOAAWVWTZNON-KHDRDAPVSA-N"
"1996","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","151.2","80.3","Degradation of EGFR L858R/T790M in H1975 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","970","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1009.339","1008.55201978","9.08","73","9","14","5","20","185.77","C56H72N12O4S","InChI=1S/C56H72N12O4S/c1-38-49(73-37-59-38)40-22-20-39(21-23-40)34-57-52(71)47-33-45(69)36-67(47)53(72)50(56(2,3)4)63-48(70)19-11-6-5-7-14-28-65-29-31-66(32-30-65)43-26-24-42(25-27-43)60-54-58-35-46-51(64-54)68(44-17-12-13-18-44)55(62-46)61-41-15-9-8-10-16-41/h8-10,15-16,20-27,35,37,44-45,47,50,69H,5-7,11-14,17-19,28-34,36H2,1-4H3,(H,57,71)(H,61,62)(H,63,70)(H,58,60,64)/t45-,47+,50-/m1/s1","OAEOAAWVWTZNON-KHDRDAPVSA-N"
"1996","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","3.54","74.8","Degradation of EGFR del19 in HCC827 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.76","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1009.339","1008.55201978","9.08","73","9","14","5","20","185.77","C56H72N12O4S","InChI=1S/C56H72N12O4S/c1-38-49(73-37-59-38)40-22-20-39(21-23-40)34-57-52(71)47-33-45(69)36-67(47)53(72)50(56(2,3)4)63-48(70)19-11-6-5-7-14-28-65-29-31-66(32-30-65)43-26-24-42(25-27-43)60-54-58-35-46-51(64-54)68(44-17-12-13-18-44)55(62-46)61-41-15-9-8-10-16-41/h8-10,15-16,20-27,35,37,44-45,47,50,69H,5-7,11-14,17-19,28-34,36H2,1-4H3,(H,57,71)(H,61,62)(H,63,70)(H,58,60,64)/t45-,47+,50-/m1/s1","OAEOAAWVWTZNON-KHDRDAPVSA-N"
"1997","P00533","EGFR","CRBN","","","CN(CCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2667","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","899.07","898.460227576","3.81","66","9","15","4","19","191.42","C48H58N12O6","InChI=1S/C48H58N12O6/c1-56(32-43(62)52-39-13-7-12-37-38(39)31-59(46(37)64)41-18-19-42(61)54-45(41)63)24-26-65-28-29-66-27-25-57-20-22-58(23-21-57)35-16-14-34(15-17-35)50-47-49-30-40-44(55-47)60(36-10-5-6-11-36)48(53-40)51-33-8-3-2-4-9-33/h2-4,7-9,12-17,30,36,41H,5-6,10-11,18-29,31-32H2,1H3,(H,51,53)(H,52,62)(H,49,50,55)(H,54,61,63)","WHRASSDAJIPBAF-UHFFFAOYSA-N"
"1997","P00533","EGFR L858R/T790M","CRBN","","","CN(CCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1211","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","899.07","898.460227576","3.81","66","9","15","4","19","191.42","C48H58N12O6","InChI=1S/C48H58N12O6/c1-56(32-43(62)52-39-13-7-12-37-38(39)31-59(46(37)64)41-18-19-42(61)54-45(41)63)24-26-65-28-29-66-27-25-57-20-22-58(23-21-57)35-16-14-34(15-17-35)50-47-49-30-40-44(55-47)60(36-10-5-6-11-36)48(53-40)51-33-8-3-2-4-9-33/h2-4,7-9,12-17,30,36,41H,5-6,10-11,18-29,31-32H2,1H3,(H,51,53)(H,52,62)(H,49,50,55)(H,54,61,63)","WHRASSDAJIPBAF-UHFFFAOYSA-N"
"1997","P00533","EGFR e19d","CRBN","","","CN(CCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.39","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","899.07","898.460227576","3.81","66","9","15","4","19","191.42","C48H58N12O6","InChI=1S/C48H58N12O6/c1-56(32-43(62)52-39-13-7-12-37-38(39)31-59(46(37)64)41-18-19-42(61)54-45(41)63)24-26-65-28-29-66-27-25-57-20-22-58(23-21-57)35-16-14-34(15-17-35)50-47-49-30-40-44(55-47)60(36-10-5-6-11-36)48(53-40)51-33-8-3-2-4-9-33/h2-4,7-9,12-17,30,36,41H,5-6,10-11,18-29,31-32H2,1H3,(H,51,53)(H,52,62)(H,49,50,55)(H,54,61,63)","WHRASSDAJIPBAF-UHFFFAOYSA-N"
"1998","P00533","EGFR e19d","CRBN","","","CN(CCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","1.91","82","Degradation of EGFR del19 in HCC827 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","943.123","942.486442324","3.67","69","9","16","4","22","200.65","C50H62N12O7","InChI=1S/C50H62N12O7/c1-58(34-45(64)54-41-13-7-12-39-40(41)33-61(48(39)66)43-18-19-44(63)56-47(43)65)24-26-67-28-30-69-31-29-68-27-25-59-20-22-60(23-21-59)37-16-14-36(15-17-37)52-49-51-32-42-46(57-49)62(38-10-5-6-11-38)50(55-42)53-35-8-3-2-4-9-35/h2-4,7-9,12-17,32,38,43H,5-6,10-11,18-31,33-34H2,1H3,(H,53,55)(H,54,64)(H,51,52,57)(H,56,63,65)","YTBOHZLAPNSENZ-UHFFFAOYSA-N"
"1998","P00533","EGFR","CRBN","","","CN(CCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1856","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","943.123","942.486442324","3.67","69","9","16","4","22","200.65","C50H62N12O7","InChI=1S/C50H62N12O7/c1-58(34-45(64)54-41-13-7-12-39-40(41)33-61(48(39)66)43-18-19-44(63)56-47(43)65)24-26-67-28-30-69-31-29-68-27-25-59-20-22-60(23-21-59)37-16-14-36(15-17-37)52-49-51-32-42-46(57-49)62(38-10-5-6-11-38)50(55-42)53-35-8-3-2-4-9-35/h2-4,7-9,12-17,32,38,43H,5-6,10-11,18-31,33-34H2,1H3,(H,53,55)(H,54,64)(H,51,52,57)(H,56,63,65)","YTBOHZLAPNSENZ-UHFFFAOYSA-N"
"1998","P00533","EGFR L858R/T790M","CRBN","","","CN(CCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3176","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","943.123","942.486442324","3.67","69","9","16","4","22","200.65","C50H62N12O7","InChI=1S/C50H62N12O7/c1-58(34-45(64)54-41-13-7-12-39-40(41)33-61(48(39)66)43-18-19-44(63)56-47(43)65)24-26-67-28-30-69-31-29-68-27-25-59-20-22-60(23-21-59)37-16-14-36(15-17-37)52-49-51-32-42-46(57-49)62(38-10-5-6-11-38)50(55-42)53-35-8-3-2-4-9-35/h2-4,7-9,12-17,32,38,43H,5-6,10-11,18-31,33-34H2,1H3,(H,53,55)(H,54,64)(H,51,52,57)(H,56,63,65)","YTBOHZLAPNSENZ-UHFFFAOYSA-N"
"1999","P00533","EGFR","CRBN","","","CN(CCOCCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2723","Inhibit proliferation of A431 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","987.176","986.512657072","3.52","72","9","17","4","25","209.88","C52H66N12O8","InChI=1S/C52H66N12O8/c1-60(36-47(66)56-43-13-7-12-41-42(43)35-63(50(41)68)45-18-19-46(65)58-49(45)67)24-26-69-28-30-71-32-33-72-31-29-70-27-25-61-20-22-62(23-21-61)39-16-14-38(15-17-39)54-51-53-34-44-48(59-51)64(40-10-5-6-11-40)52(57-44)55-37-8-3-2-4-9-37/h2-4,7-9,12-17,34,40,45H,5-6,10-11,18-33,35-36H2,1H3,(H,55,57)(H,56,66)(H,53,54,59)(H,58,65,67)","YHKWJWJTXQMPOK-UHFFFAOYSA-N"
"1999","P00533","EGFR L858R/T790M","CRBN","","","CN(CCOCCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3336","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","987.176","986.512657072","3.52","72","9","17","4","25","209.88","C52H66N12O8","InChI=1S/C52H66N12O8/c1-60(36-47(66)56-43-13-7-12-41-42(43)35-63(50(41)68)45-18-19-46(65)58-49(45)67)24-26-69-28-30-71-32-33-72-31-29-70-27-25-61-20-22-62(23-21-61)39-16-14-38(15-17-39)54-51-53-34-44-48(59-51)64(40-10-5-6-11-40)52(57-44)55-37-8-3-2-4-9-37/h2-4,7-9,12-17,34,40,45H,5-6,10-11,18-33,35-36H2,1H3,(H,55,57)(H,56,66)(H,53,54,59)(H,58,65,67)","YHKWJWJTXQMPOK-UHFFFAOYSA-N"
"1999","P00533","EGFR e19d","CRBN","","","CN(CCOCCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CC=C5)N(C5CCCC5)C4=N3)C=C2)CC1)CC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.83","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","987.176","986.512657072","3.52","72","9","17","4","25","209.88","C52H66N12O8","InChI=1S/C52H66N12O8/c1-60(36-47(66)56-43-13-7-12-41-42(43)35-63(50(41)68)45-18-19-46(65)58-49(45)67)24-26-69-28-30-71-32-33-72-31-29-70-27-25-61-20-22-62(23-21-61)39-16-14-38(15-17-39)54-51-53-34-44-48(59-51)64(40-10-5-6-11-40)52(57-44)55-37-8-3-2-4-9-37/h2-4,7-9,12-17,34,40,45H,5-6,10-11,18-33,35-36H2,1H3,(H,55,57)(H,56,66)(H,53,54,59)(H,58,65,67)","YHKWJWJTXQMPOK-UHFFFAOYSA-N"
"2000","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","999.3","998.53128434","6.95","72","9","16","5","21","187.16","C54H70N12O5S","InChI=1S/C54H70N12O5S/c1-37-47(72-36-58-37)39-16-14-38(15-17-39)33-56-50(68)46-32-44(67)35-65(46)51(69)48(54(2,3)4)55-22-28-70-30-31-71-29-27-63-23-25-64(26-24-63)42-20-18-41(19-21-42)59-52-57-34-45-49(62-52)66(43-12-8-9-13-43)53(61-45)60-40-10-6-5-7-11-40/h5-7,10-11,14-21,34,36,43-44,46,48,55,67H,8-9,12-13,22-33,35H2,1-4H3,(H,56,68)(H,60,61)(H,57,59,62)/t44-,46+,48-/m1/s1","VKKCYHNIIBYIGZ-IVTDSOLVSA-N"
"2000","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1100","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","999.3","998.53128434","6.95","72","9","16","5","21","187.16","C54H70N12O5S","InChI=1S/C54H70N12O5S/c1-37-47(72-36-58-37)39-16-14-38(15-17-39)33-56-50(68)46-32-44(67)35-65(46)51(69)48(54(2,3)4)55-22-28-70-30-31-71-29-27-63-23-25-64(26-24-63)42-20-18-41(19-21-42)59-52-57-34-45-49(62-52)66(43-12-8-9-13-43)53(61-45)60-40-10-6-5-7-11-40/h5-7,10-11,14-21,34,36,43-44,46,48,55,67H,8-9,12-13,22-33,35H2,1-4H3,(H,56,68)(H,60,61)(H,57,59,62)/t44-,46+,48-/m1/s1","VKKCYHNIIBYIGZ-IVTDSOLVSA-N"
"2000","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","53.49","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","999.3","998.53128434","6.95","72","9","16","5","21","187.16","C54H70N12O5S","InChI=1S/C54H70N12O5S/c1-37-47(72-36-58-37)39-16-14-38(15-17-39)33-56-50(68)46-32-44(67)35-65(46)51(69)48(54(2,3)4)55-22-28-70-30-31-71-29-27-63-23-25-64(26-24-63)42-20-18-41(19-21-42)59-52-57-34-45-49(62-52)66(43-12-8-9-13-43)53(61-45)60-40-10-6-5-7-11-40/h5-7,10-11,14-21,34,36,43-44,46,48,55,67H,8-9,12-13,22-33,35H2,1-4H3,(H,56,68)(H,60,61)(H,57,59,62)/t44-,46+,48-/m1/s1","VKKCYHNIIBYIGZ-IVTDSOLVSA-N"
"2001","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1043.353","1042.55749909","6.81","75","9","17","5","24","196.39","C56H74N12O6S","InChI=1S/C56H74N12O6S/c1-39-49(75-38-60-39)41-16-14-40(15-17-41)35-58-52(70)48-34-46(69)37-67(48)53(71)50(56(2,3)4)57-22-28-72-30-32-74-33-31-73-29-27-65-23-25-66(26-24-65)44-20-18-43(19-21-44)61-54-59-36-47-51(64-54)68(45-12-8-9-13-45)55(63-47)62-42-10-6-5-7-11-42/h5-7,10-11,14-21,36,38,45-46,48,50,57,69H,8-9,12-13,22-35,37H2,1-4H3,(H,58,70)(H,62,63)(H,59,61,64)/t46-,48+,50-/m1/s1","HUPCKZOCINPJII-AJKYVBNFSA-N"
"2001","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2100","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1043.353","1042.55749909","6.81","75","9","17","5","24","196.39","C56H74N12O6S","InChI=1S/C56H74N12O6S/c1-39-49(75-38-60-39)41-16-14-40(15-17-41)35-58-52(70)48-34-46(69)37-67(48)53(71)50(56(2,3)4)57-22-28-72-30-32-74-33-31-73-29-27-65-23-25-66(26-24-65)44-20-18-43(19-21-44)61-54-59-36-47-51(64-54)68(45-12-8-9-13-45)55(63-47)62-42-10-6-5-7-11-42/h5-7,10-11,14-21,36,38,45-46,48,50,57,69H,8-9,12-13,22-35,37H2,1-4H3,(H,58,70)(H,62,63)(H,59,61,64)/t46-,48+,50-/m1/s1","HUPCKZOCINPJII-AJKYVBNFSA-N"
"2001","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","54.38","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1043.353","1042.55749909","6.81","75","9","17","5","24","196.39","C56H74N12O6S","InChI=1S/C56H74N12O6S/c1-39-49(75-38-60-39)41-16-14-40(15-17-41)35-58-52(70)48-34-46(69)37-67(48)53(71)50(56(2,3)4)57-22-28-72-30-32-74-33-31-73-29-27-65-23-25-66(26-24-65)44-20-18-43(19-21-44)61-54-59-36-47-51(64-54)68(45-12-8-9-13-45)55(63-47)62-42-10-6-5-7-11-42/h5-7,10-11,14-21,36,38,45-46,48,50,57,69H,8-9,12-13,22-35,37H2,1-4H3,(H,58,70)(H,62,63)(H,59,61,64)/t46-,48+,50-/m1/s1","HUPCKZOCINPJII-AJKYVBNFSA-N"
"2002","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1087.406","1086.58371384","6.66","78","9","18","5","27","205.62","C58H78N12O7S","InChI=1S/C58H78N12O7S/c1-41-51(78-40-62-41)43-16-14-42(15-17-43)37-60-54(72)50-36-48(71)39-69(50)55(73)52(58(2,3)4)59-22-28-74-30-32-76-34-35-77-33-31-75-29-27-67-23-25-68(26-24-67)46-20-18-45(19-21-46)63-56-61-38-49-53(66-56)70(47-12-8-9-13-47)57(65-49)64-44-10-6-5-7-11-44/h5-7,10-11,14-21,38,40,47-48,50,52,59,71H,8-9,12-13,22-37,39H2,1-4H3,(H,60,72)(H,64,65)(H,61,63,66)/t48-,50+,52-/m1/s1","BPHMNBCRTHSRFO-KPYPFJKESA-N"
"2002","P00533","EGFR L858R/T790M","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2894","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1087.406","1086.58371384","6.66","78","9","18","5","27","205.62","C58H78N12O7S","InChI=1S/C58H78N12O7S/c1-41-51(78-40-62-41)43-16-14-42(15-17-43)37-60-54(72)50-36-48(71)39-69(50)55(73)52(58(2,3)4)59-22-28-74-30-32-76-34-35-77-33-31-75-29-27-67-23-25-68(26-24-67)46-20-18-45(19-21-46)63-56-61-38-49-53(66-56)70(47-12-8-9-13-47)57(65-49)64-44-10-6-5-7-11-44/h5-7,10-11,14-21,38,40,47-48,50,52,59,71H,8-9,12-13,22-37,39H2,1-4H3,(H,60,72)(H,64,65)(H,61,63,66)/t48-,50+,52-/m1/s1","BPHMNBCRTHSRFO-KPYPFJKESA-N"
"2002","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NCCOCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6N=C(NC7=CC=CC=C7)N(C7CCCC7)C6=N5)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","62","Inhibit proliferation of HCC827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2020.112781","1087.406","1086.58371384","6.66","78","9","18","5","27","205.62","C58H78N12O7S","InChI=1S/C58H78N12O7S/c1-41-51(78-40-62-41)43-16-14-42(15-17-43)37-60-54(72)50-36-48(71)39-69(50)55(73)52(58(2,3)4)59-22-28-74-30-32-76-34-35-77-33-31-75-29-27-67-23-25-68(26-24-67)46-20-18-45(19-21-46)63-56-61-38-49-53(66-56)70(47-12-8-9-13-47)57(65-49)64-44-10-6-5-7-11-44/h5-7,10-11,14-21,38,40,47-48,50,52,59,71H,8-9,12-13,22-37,39H2,1-4H3,(H,60,72)(H,64,65)(H,61,63,66)/t48-,50+,52-/m1/s1","BPHMNBCRTHSRFO-KPYPFJKESA-N"
"2003","Q92793","CBP","CRBN","","","CNC(=O)N1CCC2=C(C1)C(N1CCCC3=CC(C4=CN(C)N=C4)=C(C(F)F)C=C31)=NN2C1CCN(C(=O)CCOCCOCCOCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5","Inhibit proliferation of MM1S cells","","","","","","","","","","","10.1016/j.chembiol.2020.12.004","1028.128","1027.47274366","1.57","74","9","16","3","21","224.03","C51H63F2N11O10","InChI=1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42)67/h5-6,26-30,35,42,46,55H,3-4,7-25,31H2,1-2H3,(H,54,70)(H,57,65,67)","ILVRLRGBSSFKIE-UHFFFAOYSA-N"
"2003","Q09472","EP300","CRBN","","","CNC(=O)N1CCC2=C(C1)C(N1CCCC3=CC(C4=CN(C)N=C4)=C(C(F)F)C=C31)=NN2C1CCN(C(=O)CCOCCOCCOCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5","Inhibit proliferation of MM1S cells","","","","","","","","","","","10.1016/j.chembiol.2020.12.004","1028.128","1027.47274366","1.57","74","9","16","3","21","224.03","C51H63F2N11O10","InChI=1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42)67/h5-6,26-30,35,42,46,55H,3-4,7-25,31H2,1-2H3,(H,54,70)(H,57,65,67)","ILVRLRGBSSFKIE-UHFFFAOYSA-N"
"2004","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","46","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","5","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","1016","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","802.849","802.318708304","2.28","59","7","13","5","13","246.61","C41H42N10O8","InChI=1S/C41H42N10O8/c1-22(2)47-29-17-32(50-15-12-25-16-23(18-42)19-46-36(25)50)45-20-28(29)38(55)48-26-8-6-24(7-9-26)37(54)44-14-13-43-34(53)21-59-31-5-3-4-27-35(31)41(58)51(40(27)57)30-10-11-33(52)49-39(30)56/h3-5,12,15-17,19-20,22,24,26,30H,6-11,13-14,21H2,1-2H3,(H,43,53)(H,44,54)(H,45,47)(H,48,55)(H,49,52,56)/t24-,26-,30?","YMXWKCAXGFLWAH-MONLTZSXSA-N"
"2005","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","485","92","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","5","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","490","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","816.876","816.334358368","2.64","60","7","13","5","14","246.61","C42H44N10O8","InChI=1S/C42H44N10O8/c1-23(2)48-30-18-33(51-16-13-26-17-24(19-43)20-47-37(26)51)46-21-29(30)39(56)49-27-9-7-25(8-10-27)38(55)45-15-4-14-44-35(54)22-60-32-6-3-5-28-36(32)42(59)52(41(28)58)31-11-12-34(53)50-40(31)57/h3,5-6,13,16-18,20-21,23,25,27,31H,4,7-12,14-15,22H2,1-2H3,(H,44,54)(H,45,55)(H,46,48)(H,49,56)(H,50,53,57)/t25-,27-,31?","DHVQDOJINANBTP-NYHQYBDOSA-N"
"2006","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","190","93","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","7","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","768","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","830.903","830.350008432","3.0","61","7","13","5","15","246.61","C43H46N10O8","InChI=1S/C43H46N10O8/c1-24(2)49-31-19-34(52-17-14-27-18-25(20-44)21-48-38(27)52)47-22-30(31)40(57)50-28-10-8-26(9-11-28)39(56)46-16-4-3-15-45-36(55)23-61-33-7-5-6-29-37(33)43(60)53(42(29)59)32-12-13-35(54)51-41(32)58/h5-7,14,17-19,21-22,24,26,28,32H,3-4,8-13,15-16,23H2,1-2H3,(H,45,55)(H,46,56)(H,47,49)(H,50,57)(H,51,54,58)/t26-,28-,32?","HTWBTPRKNVRYHW-OAMJFVEXSA-N"
"2007","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCCCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","293","97","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","26","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","1030","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","844.93","844.365658496","3.36","62","7","13","5","16","246.61","C44H48N10O8","InChI=1S/C44H48N10O8/c1-25(2)50-32-20-35(53-18-15-28-19-26(21-45)22-49-39(28)53)48-23-31(32)41(58)51-29-11-9-27(10-12-29)40(57)47-17-5-3-4-16-46-37(56)24-62-34-8-6-7-30-38(34)44(61)54(43(30)60)33-13-14-36(55)52-42(33)59/h6-8,15,18-20,22-23,25,27,29,33H,3-5,9-14,16-17,24H2,1-2H3,(H,46,56)(H,47,57)(H,48,50)(H,51,58)(H,52,55,59)/t27-,29-,33?","NOGGUZVPDPKPMG-SNOFGSQBSA-N"
"2008","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","405","90","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","7","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","609","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","846.902","846.344923052","2.14","62","7","14","5","16","255.84","C43H46N10O9","InChI=1S/C43H46N10O9/c1-24(2)49-31-19-34(52-15-12-27-18-25(20-44)21-48-38(27)52)47-22-30(31)40(57)50-28-8-6-26(7-9-28)39(56)46-14-17-61-16-13-45-36(55)23-62-33-5-3-4-29-37(33)43(60)53(42(29)59)32-10-11-35(54)51-41(32)58/h3-5,12,15,18-19,21-22,24,26,28,32H,6-11,13-14,16-17,23H2,1-2H3,(H,45,55)(H,46,56)(H,47,49)(H,50,57)(H,51,54,58)/t26-,28-,32?","YNNBDJQWDDDBRU-OAMJFVEXSA-N"
"2009","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","7420","71","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","12","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","680","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","890.955","890.3711378","1.99","65","7","15","5","19","265.07","C45H50N10O10","InChI=1S/C45H50N10O10/c1-26(2)51-33-21-36(54-15-12-29-20-27(22-46)23-50-40(29)54)49-24-32(33)42(59)52-30-8-6-28(7-9-30)41(58)48-14-17-64-19-18-63-16-13-47-38(57)25-65-35-5-3-4-31-39(35)45(62)55(44(31)61)34-10-11-37(56)53-43(34)60/h3-5,12,15,20-21,23-24,26,28,30,34H,6-11,13-14,16-19,25H2,1-2H3,(H,47,57)(H,48,58)(H,49,51)(H,52,59)(H,53,56,60)/t28-,30-,34?","OLRLOHZCSMMOCS-BVRPOGDGSA-N"
"2010","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","47","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","19","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","1080","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","935.008","934.397352548","1.84","68","7","16","5","22","274.3","C47H54N10O11","InChI=1S/C47H54N10O11/c1-28(2)53-35-23-38(56-15-12-31-22-29(24-48)25-52-42(31)56)51-26-34(35)44(61)54-32-8-6-30(7-9-32)43(60)50-14-17-66-19-21-67-20-18-65-16-13-49-40(59)27-68-37-5-3-4-33-41(37)47(64)57(46(33)63)36-10-11-39(58)55-45(36)62/h3-5,12,15,22-23,25-26,28,30,32,36H,6-11,13-14,16-21,27H2,1-2H3,(H,49,59)(H,50,60)(H,51,53)(H,54,61)(H,55,58,62)/t30-,32-,36?","GCYQSLZQVIWPNR-LKIQTYDKSA-N"
"2011","Q9NWZ3","IRAK4","CRBN","","","CC(C)NC1=CC(N2C=CC3=CC(C#N)=CN=C32)=NC=C1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","30","Degradation of IRAK4 in HEK293T cells after 24 h treatment","","","18","IC50 was assessed by Caliper biochemistry assay","","","","","","","","","","","","","","","","","","","900","TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.chembiol.2020.08.010","979.061","978.423567296","1.69","71","7","17","5","25","283.53","C49H58N10O12","InChI=1S/C49H58N10O12/c1-30(2)55-37-25-40(58-15-12-33-24-31(26-50)27-54-44(33)58)53-28-36(37)46(63)56-34-8-6-32(7-9-34)45(62)52-14-17-68-19-21-70-23-22-69-20-18-67-16-13-51-42(61)29-71-39-5-3-4-35-43(39)49(66)59(48(35)65)38-10-11-41(60)57-47(38)64/h3-5,12,15,24-25,27-28,30,32,34,38H,6-11,13-14,16-23,29H2,1-2H3,(H,51,61)(H,52,62)(H,53,55)(H,56,63)(H,57,60,64)/t32-,34-,38?","TXUGEBSJIQYPRD-ULRIJCTKSA-N"
"2012","O15379","HDAC3","CRBN","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)COCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C=C1","","","","","","43","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","670.723","670.275112176","2.83","49","5","10","5","16","184.27","C35H38N6O8","InChI=1S/C35H38N6O8/c1-2-16-37-40-32(44)24-8-6-22(7-9-24)23-10-12-25(13-11-23)38-30(43)21-49-20-19-48-18-17-36-27-5-3-4-26-31(27)35(47)41(34(26)46)28-14-15-29(42)39-33(28)45/h3-13,28,36-37H,2,14-21H2,1H3,(H,38,43)(H,40,44)(H,39,42,45)","KVPVXIKCRDVWAF-UHFFFAOYSA-N"
"2013","O15379","HDAC3","CRBN","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)COCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C=C1","","","","","","38","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","714.776","714.301326924","2.68","52","5","11","5","19","193.5","C37H42N6O9","InChI=1S/C37H42N6O9/c1-2-16-39-42-34(46)26-8-6-24(7-9-26)25-10-12-27(13-11-25)40-32(45)23-52-22-21-51-20-19-50-18-17-38-29-5-3-4-28-33(29)37(49)43(36(28)48)30-14-15-31(44)41-35(30)47/h3-13,30,38-39H,2,14-23H2,1H3,(H,40,45)(H,42,46)(H,41,44,47)","BXZABYBAJLFFDG-UHFFFAOYSA-N"
"2014","O15379","HDAC3","CRBN","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)COCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)C=C1","","","","","","72","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","758.829","758.327541672","2.54","55","5","12","5","22","202.73","C39H46N6O10","InChI=1S/C39H46N6O10/c1-2-16-41-44-36(48)28-8-6-26(7-9-28)27-10-12-29(13-11-27)42-34(47)25-55-24-23-54-22-21-53-20-19-52-18-17-40-31-5-3-4-30-35(31)39(51)45(38(30)50)32-14-15-33(46)43-37(32)49/h3-13,32,40-41H,2,14-25H2,1H3,(H,42,47)(H,44,48)(H,43,46,49)","RVVZCFKZBFPOPL-UHFFFAOYSA-N"
"2015","O15379","HDAC3","VHL","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)C=C1","","","","","","140","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","796.007","795.377803416","5.01","57","5","9","6","15","181.86","C43H53N7O6S","InChI=1S/C43H53N7O6S/c1-7-22-45-49-40(54)32-14-10-29(11-15-32)30-16-18-33(19-17-30)47-36(52)20-21-37(53)48-39(43(4,5)6)42(56)50-24-34(51)23-35(50)41(55)46-26(2)28-8-12-31(13-9-28)38-27(3)44-25-57-38/h8-19,25-26,34-35,39,45,51H,7,20-24H2,1-6H3,(H,46,55)(H,47,52)(H,48,53)(H,49,54)/t26-,34+,35-,39+/m0/s1","ZKFSGJOYCIDBEC-JGDCMZFZSA-N"
"2016","O15379","HDAC3","VHL","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)C=C1","","","","","","320","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","824.061","823.409103544","5.73","59","5","9","6","17","181.86","C45H57N7O6S","InChI=1S/C45H57N7O6S/c1-7-24-47-51-42(56)34-18-14-31(15-19-34)32-20-22-35(23-21-32)49-38(54)10-8-9-11-39(55)50-41(45(4,5)6)44(58)52-26-36(53)25-37(52)43(57)48-28(2)30-12-16-33(17-13-30)40-29(3)46-27-59-40/h12-23,27-28,36-37,41,47,53H,7-11,24-26H2,1-6H3,(H,48,57)(H,49,54)(H,50,55)(H,51,56)/t28-,36+,37-,41+/m0/s1","NNXLBEPZRGQLMS-RYJGHSPWSA-N"
"2017","O15379","HDAC3","VHL","","XZ9002","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)C=C1","42","","Degradation of HDAC3 in MDA-MB-468 cells after 14 h treatment","","","350","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2570/3690/6140","Inhibit viability of MDA-MB-468/MDA-MB-231/T47D cells","","","","","","","","","","","","","","","10.1039/d0cc03243c","852.115","851.440403672","6.81","61","5","9","6","19","181.86","C47H61N7O6S","InChI=1S/C47H61N7O6S/c1-7-26-49-53-44(58)36-20-16-33(17-21-36)34-22-24-37(25-23-34)51-40(56)12-10-8-9-11-13-41(57)52-43(47(4,5)6)46(60)54-28-38(55)27-39(54)45(59)50-30(2)32-14-18-35(19-15-32)42-31(3)48-29-61-42/h14-25,29-30,38-39,43,49,55H,7-13,26-28H2,1-6H3,(H,50,59)(H,51,56)(H,52,57)(H,53,58)/t30-,38+,39-,43+/m0/s1","INXGMIWEZJNJOA-NVZKIFIHSA-N"
"2018","O15379","HDAC3","VHL","","","CCCNNC(=O)C1=CC=C(C2=CC=C(NC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)C=C1","","","","","","550","IC50 was assessed by HDAC-Glot I/II Assays","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0cc03243c","880.169","879.4717038","7.89","63","5","9","6","21","181.86","C49H65N7O6S","InChI=1S/C49H65N7O6S/c1-7-28-51-55-46(60)38-22-18-35(19-23-38)36-24-26-39(27-25-36)53-42(58)14-12-10-8-9-11-13-15-43(59)54-45(49(4,5)6)48(62)56-30-40(57)29-41(56)47(61)52-32(2)34-16-20-37(21-17-34)44-33(3)50-31-63-44/h16-27,31-32,40-41,45,51,57H,7-15,28-30H2,1-6H3,(H,52,61)(H,53,58)(H,54,59)(H,55,60)/t32-,40+,41-,45+/m0/s1","DFGBWDYHGYANKS-ZHGKKRJTSA-N"
"2019","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","816.92","816.370743876","3.18","60","8","14","3","13","208.9","C43H48N10O7","InChI=1S/C43H48N10O7/c1-25-30-24-46-43(49-38(30)52(27-9-5-6-10-27)41(59)36(25)26(2)54)47-33-16-14-28(23-45-33)50-19-21-51(22-20-50)35(56)13-4-3-7-18-44-31-12-8-11-29-37(31)42(60)53(40(29)58)32-15-17-34(55)48-39(32)57/h8,11-12,14,16,23-24,27,32,44H,3-7,9-10,13,15,17-22H2,1-2H3,(H,48,55,57)(H,45,46,47,49)","SBQOAVDBMVISJT-UHFFFAOYSA-N"
"2019","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","816.92","816.370743876","3.18","60","8","14","3","13","208.9","C43H48N10O7","InChI=1S/C43H48N10O7/c1-25-30-24-46-43(49-38(30)52(27-9-5-6-10-27)41(59)36(25)26(2)54)47-33-16-14-28(23-45-33)50-19-21-51(22-20-50)35(56)13-4-3-7-18-44-31-12-8-11-29-37(31)42(60)53(40(29)58)32-15-17-34(55)48-39(32)57/h8,11-12,14,16,23-24,27,32,44H,3-7,9-10,13,15,17-22H2,1-2H3,(H,48,55,57)(H,45,46,47,49)","SBQOAVDBMVISJT-UHFFFAOYSA-N"
"2020","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)COCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","848.918","848.360573116","1.91","62","8","16","3","15","227.36","C43H48N10O9","InChI=1S/C43H48N10O9/c1-25-30-23-46-43(49-38(30)52(27-6-3-4-7-27)41(59)36(25)26(2)54)47-33-12-10-28(22-45-33)50-15-17-51(18-16-50)35(56)24-62-21-20-61-19-14-44-31-9-5-8-29-37(31)42(60)53(40(29)58)32-11-13-34(55)48-39(32)57/h5,8-10,12,22-23,27,32,44H,3-4,6-7,11,13-21,24H2,1-2H3,(H,48,55,57)(H,45,46,47,49)","ZIKZMNKRJCLMCF-UHFFFAOYSA-N"
"2020","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)COCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","848.918","848.360573116","1.91","62","8","16","3","15","227.36","C43H48N10O9","InChI=1S/C43H48N10O9/c1-25-30-23-46-43(49-38(30)52(27-6-3-4-7-27)41(59)36(25)26(2)54)47-33-12-10-28(22-45-33)50-15-17-51(18-16-50)35(56)24-62-21-20-61-19-14-44-31-9-5-8-29-37(31)42(60)53(40(29)58)32-11-13-34(55)48-39(32)57/h5,8-10,12,22-23,27,32,44H,3-4,6-7,11,13-21,24H2,1-2H3,(H,48,55,57)(H,45,46,47,49)","ZIKZMNKRJCLMCF-UHFFFAOYSA-N"
"2021","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)COCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","892.971","892.386787864","1.76","65","8","17","3","18","236.59","C45H52N10O10","InChI=1S/C45H52N10O10/c1-27-32-25-48-45(51-40(32)54(29-6-3-4-7-29)43(61)38(27)28(2)56)49-35-12-10-30(24-47-35)52-15-17-53(18-16-52)37(58)26-65-23-22-64-21-20-63-19-14-46-33-9-5-8-31-39(33)44(62)55(42(31)60)34-11-13-36(57)50-41(34)59/h5,8-10,12,24-25,29,34,46H,3-4,6-7,11,13-23,26H2,1-2H3,(H,50,57,59)(H,47,48,49,51)","SSCUDTQISAHARD-UHFFFAOYSA-N"
"2021","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)COCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","892.971","892.386787864","1.76","65","8","17","3","18","236.59","C45H52N10O10","InChI=1S/C45H52N10O10/c1-27-32-25-48-45(51-40(32)54(29-6-3-4-7-29)43(61)38(27)28(2)56)49-35-12-10-30(24-47-35)52-15-17-53(18-16-52)37(58)26-65-23-22-64-21-20-63-19-14-46-33-9-5-8-31-39(33)44(62)55(42(31)60)34-11-13-36(57)50-41(34)59/h5,8-10,12,24-25,29,34,46H,3-4,6-7,11,13-23,26H2,1-2H3,(H,50,57,59)(H,47,48,49,51)","SSCUDTQISAHARD-UHFFFAOYSA-N"
"2022","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","935.052","934.433738056","2.38","68","8","17","3","21","236.59","C48H58N10O10","InChI=1S/C48H58N10O10/c1-30-35-29-51-48(54-43(35)57(32-8-3-4-9-32)46(64)41(30)31(2)59)52-38-15-13-33(28-50-38)55-18-20-56(21-19-55)40(61)12-5-6-22-66-24-26-68-27-25-67-23-17-49-36-11-7-10-34-42(36)47(65)58(45(34)63)37-14-16-39(60)53-44(37)62/h7,10-11,13,15,28-29,32,37,49H,3-6,8-9,12,14,16-27H2,1-2H3,(H,53,60,62)(H,50,51,52,54)","XUTKYZDUTICBNU-UHFFFAOYSA-N"
"2022","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","935.052","934.433738056","2.38","68","8","17","3","21","236.59","C48H58N10O10","InChI=1S/C48H58N10O10/c1-30-35-29-51-48(54-43(35)57(32-8-3-4-9-32)46(64)41(30)31(2)59)52-38-15-13-33(28-50-38)55-18-20-56(21-19-55)40(61)12-5-6-22-66-24-26-68-27-25-67-23-17-49-36-11-7-10-34-42(36)47(65)58(45(34)63)37-14-16-39(60)53-44(37)62/h7,10-11,13,15,28-29,32,37,49H,3-6,8-9,12,14,16-27H2,1-2H3,(H,53,60,62)(H,50,51,52,54)","XUTKYZDUTICBNU-UHFFFAOYSA-N"
"2023","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCC(=O)NCCCOCCCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","990.132","989.475937216","2.49","72","8","17","4","23","256.46","C51H63N11O10","InChI=1S/C51H63N11O10/c1-32-37-31-55-51(58-46(37)61(34-10-3-4-11-34)49(69)44(32)33(2)63)56-40-16-14-35(30-54-40)59-22-24-60(25-23-59)43(66)19-18-41(64)53-21-9-29-72-27-6-5-26-71-28-8-20-52-38-13-7-12-36-45(38)50(70)62(48(36)68)39-15-17-42(65)57-47(39)67/h7,12-14,16,30-31,34,39,52H,3-6,8-11,15,17-29H2,1-2H3,(H,53,64)(H,57,65,67)(H,54,55,56,58)","DHMSRICIWHOFOD-UHFFFAOYSA-N"
"2023","P11802","CDK4","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCC(=O)NCCCOCCCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","990.132","989.475937216","2.49","72","8","17","4","23","256.46","C51H63N11O10","InChI=1S/C51H63N11O10/c1-32-37-31-55-51(58-46(37)61(34-10-3-4-11-34)49(69)44(32)33(2)63)56-40-16-14-35(30-54-40)59-22-24-60(25-23-59)43(66)19-18-41(64)53-21-9-29-72-27-6-5-26-71-28-8-20-52-38-13-7-12-36-45(38)50(70)62(48(36)68)39-15-17-42(65)57-47(39)67/h7,12-14,16,30-31,34,39,52H,3-6,8-11,15,17-29H2,1-2H3,(H,53,64)(H,57,65,67)(H,54,55,56,58)","DHMSRICIWHOFOD-UHFFFAOYSA-N"
"2024","Q00534","CDK6","CRBN","","","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CCCCOCCCCCOCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","989.188","988.517073756","5.03","72","8","16","3","25","227.36","C53H68N10O9","InChI=1S/C53H68N10O9/c1-35-40-34-56-53(59-48(40)62(37-15-6-7-16-37)51(69)46(35)36(2)64)57-43-22-20-38(33-55-43)60-25-27-61(28-26-60)45(66)19-8-13-32-72-31-12-5-11-30-71-29-10-4-3-9-24-54-41-18-14-17-39-47(41)52(70)63(50(39)68)42-21-23-44(65)58-49(42)67/h14,17-18,20,22,33-34,37,42,54H,3-13,15-16,19,21,23-32H2,1-2H3,(H,58,65,67)(H,55,56,57,59)","YJUHHLNRNPHHGU-UHFFFAOYSA-N"
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"2038","P11802","CDK4","VHL","","CST651","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@@H](NC(=O)C5(F)CC5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","20","","Degradation of CDK4 in MM.1S cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","450","Inhibit viability of HEL cells","","","","","","","","","","","","","","","10.1039/d0sc00167h","1094.325","1093.5219221","4.76","78","9","18","4","22","235.57","C56H72FN11O9S","InChI=1S/C56H72FN11O9S/c1-34-42-31-60-54(64-49(42)68(39-9-7-8-10-39)51(72)46(34)36(3)69)62-45-14-13-40(30-58-45)66-19-17-65(18-20-66)21-22-75-23-24-76-25-26-77-44-27-37(47-35(2)61-33-78-47)11-12-38(44)29-59-50(71)43-28-41(70)32-67(43)52(73)48(55(4,5)6)63-53(74)56(57)15-16-56/h11-14,27,30-31,33,39,41,43,48,70H,7-10,15-26,28-29,32H2,1-6H3,(H,59,71)(H,63,74)(H,58,60,62,64)/t41-,43+,48-/m1/s1","WYPMPGWHIPETEB-VZUPZQALSA-N"
"2038","Q00534","CDK6","VHL","","CST651","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@@H](NC(=O)C5(F)CC5)C(C)(C)C)CC4)C=N3)N=C2N(C2CCCC2)C1=O","5.1",">95","Degradation of CDK6 in MM.1S cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","450","Inhibit viability of HEL cells","","","","","","","","","","","","","","","10.1039/d0sc00167h","1094.325","1093.5219221","4.76","78","9","18","4","22","235.57","C56H72FN11O9S","InChI=1S/C56H72FN11O9S/c1-34-42-31-60-54(64-49(42)68(39-9-7-8-10-39)51(72)46(34)36(3)69)62-45-14-13-40(30-58-45)66-19-17-65(18-20-66)21-22-75-23-24-76-25-26-77-44-27-37(47-35(2)61-33-78-47)11-12-38(44)29-59-50(71)43-28-41(70)32-67(43)52(73)48(55(4,5)6)63-53(74)56(57)15-16-56/h11-14,27,30-31,33,39,41,43,48,70H,7-10,15-26,28-29,32H2,1-6H3,(H,59,71)(H,63,74)(H,58,60,62,64)/t41-,43+,48-/m1/s1","WYPMPGWHIPETEB-VZUPZQALSA-N"
"2039","Q00534","CDK6","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](OC2=CC=CC(OCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6C(C)=C(C(C)=O)C(=O)N(C7CCCC7)C6=N5)N=C4)CC3)=C2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","25/82","% CDK6 degradation in MM.1S cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","1182.478","1181.66373798","6.58","86","10","18","4","27","232.94","C65H87N11O10","InChI=1S/C65H87N11O10/c1-43-54-41-68-65(72-60(54)76(48-18-9-10-19-48)63(80)58(43)45(3)77)70-57-25-24-49(40-67-57)74-28-26-73(27-29-74)30-31-82-32-33-83-34-35-84-36-37-85-50-20-13-21-51(38-50)86-52-39-56(62(79)69-55-23-12-17-46-14-8-11-22-53(46)55)75(42-52)64(81)59(47-15-6-5-7-16-47)71-61(78)44(2)66-4/h8,11,13-14,20-22,24-25,38,40-41,44,47-48,52,55-56,59,66H,5-7,9-10,12,15-19,23,26-37,39,42H2,1-4H3,(H,69,79)(H,71,78)(H,67,68,70,72)/t44-,52-,55+,56-,59-/m0/s1","ZGJRSUQTJKRDJL-FFDUWMPJSA-N"
"2039","P11802","CDK4","XIAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](OC2=CC=CC(OCCOCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C6C(C)=C(C(C)=O)C(=O)N(C7CCCC7)C6=N5)N=C4)CC3)=C2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","1182.478","1181.66373798","6.58","86","10","18","4","27","232.94","C65H87N11O10","InChI=1S/C65H87N11O10/c1-43-54-41-68-65(72-60(54)76(48-18-9-10-19-48)63(80)58(43)45(3)77)70-57-25-24-49(40-67-57)74-28-26-73(27-29-74)30-31-82-32-33-83-34-35-84-36-37-85-50-20-13-21-51(38-50)86-52-39-56(62(79)69-55-23-12-17-46-14-8-11-22-53(46)55)75(42-52)64(81)59(47-15-6-5-7-16-47)71-61(78)44(2)66-4/h8,11,13-14,20-22,24-25,38,40-41,44,47-48,52,55-56,59,66H,5-7,9-10,12,15-19,23,26-37,39,42H2,1-4H3,(H,69,79)(H,71,78)(H,67,68,70,72)/t44-,52-,55+,56-,59-/m0/s1","ZGJRSUQTJKRDJL-FFDUWMPJSA-N"
"2040","Q00534","CDK6","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","","","0/0","% CDK6 degradation in MM.1S cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","1221.248","1219.4988701","7.93","86","9","17","4","24","227.19","C63H73Cl2F2N11O8","InChI=1S/C63H73Cl2F2N11O8/c1-38-45-36-71-61(75-57(45)78(42-10-7-8-11-42)60(82)53(38)39(2)79)74-52-19-16-43(35-70-52)77-23-21-76(22-24-77)25-27-85-29-31-86-30-28-84-26-20-69-58(80)40-14-18-49(50(32-40)83-6)72-59(81)56-54(44-12-9-13-47(65)55(44)67)63(37-68,51(73-56)34-62(3,4)5)46-17-15-41(64)33-48(46)66/h9,12-19,32-33,35-36,42,51,54,56,73H,7-8,10-11,20-31,34H2,1-6H3,(H,69,80)(H,72,81)(H,70,71,74,75)/t51-,54-,56+,63-/m0/s1","XRGFJEIUSASXRL-IRRFVDKPSA-N"
"2040","P11802","CDK4","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCCN2CCN(C3=CC=C(NC4=NC=C5C(C)=C(C(C)=O)C(=O)N(C6CCCC6)C5=N4)N=C3)CC2)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","","","0/0","% CDK4 degradation in MM.1S cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1039/d0sc00167h","1221.248","1219.4988701","7.93","86","9","17","4","24","227.19","C63H73Cl2F2N11O8","InChI=1S/C63H73Cl2F2N11O8/c1-38-45-36-71-61(75-57(45)78(42-10-7-8-11-42)60(82)53(38)39(2)79)74-52-19-16-43(35-70-52)77-23-21-76(22-24-77)25-27-85-29-31-86-30-28-84-26-20-69-58(80)40-14-18-49(50(32-40)83-6)72-59(81)56-54(44-12-9-13-47(65)55(44)67)63(37-68,51(73-56)34-62(3,4)5)46-17-15-41(64)33-48(46)66/h9,12-19,32-33,35-36,42,51,54,56,73H,7-8,10-11,20-31,34H2,1-6H3,(H,69,80)(H,72,81)(H,70,71,74,75)/t51-,54-,56+,63-/m0/s1","XRGFJEIUSASXRL-IRRFVDKPSA-N"
"2041","O14965","AURKA","CRBN","","dAURK-4","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","1035.483","1034.337725","4.26","74","8","16","4","24","247.3","C52H52ClFN8O12","InChI=1S/C52H52ClFN8O12/c1-69-39-9-4-8-37(54)45(39)47-36-25-31(53)11-13-33(36)46-30(27-57-47)28-58-52(61-46)59-32-12-14-34(41(26-32)70-2)48(65)56-18-6-20-72-22-24-73-23-21-71-19-5-17-55-43(64)29-74-40-10-3-7-35-44(40)51(68)62(50(35)67)38-15-16-42(63)60-49(38)66/h3-4,7-14,25-26,28,38H,5-6,15-24,27,29H2,1-2H3,(H,55,64)(H,56,65)(H,58,59,61)(H,60,63,66)","AQMSIRIHYNCQKO-UHFFFAOYSA-N"
"2041","Q96GD4","AURKB","CRBN","","dAURK-4","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.cell.2020.10.038","1035.483","1034.337725","4.26","74","8","16","4","24","247.3","C52H52ClFN8O12","InChI=1S/C52H52ClFN8O12/c1-69-39-9-4-8-37(54)45(39)47-36-25-31(53)11-13-33(36)46-30(27-57-47)28-58-52(61-46)59-32-12-14-34(41(26-32)70-2)48(65)56-18-6-20-72-22-24-73-23-21-71-19-5-17-55-43(64)29-74-40-10-3-7-35-44(40)51(68)62(50(35)67)38-15-16-42(63)60-49(38)66/h3-4,7-14,25-26,28,38H,5-6,15-24,27,29H2,1-2H3,(H,55,64)(H,56,65)(H,58,59,61)(H,60,63,66)","AQMSIRIHYNCQKO-UHFFFAOYSA-N"
"2041","O14965","AURKA","CRBN","","JB158","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCCOCCOCCOCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","1035.483","1034.337725","4.26","74","8","16","4","24","247.3","C52H52ClFN8O12","InChI=1S/C52H52ClFN8O12/c1-69-39-9-4-8-37(54)45(39)47-36-25-31(53)11-13-33(36)46-30(27-57-47)28-58-52(61-46)59-32-12-14-34(41(26-32)70-2)48(65)56-18-6-20-72-22-24-73-23-21-71-19-5-17-55-43(64)29-74-40-10-3-7-35-44(40)51(68)62(50(35)67)38-15-16-42(63)60-49(38)66/h3-4,7-14,25-26,28,38H,5-6,15-24,27,29H2,1-2H3,(H,55,64)(H,56,65)(H,58,59,61)(H,60,63,66)","AQMSIRIHYNCQKO-UHFFFAOYSA-N"
"2042","O14965","AURKA","CRBN","","JB159","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","889.297","888.243430696","4.34","64","8","13","4","14","219.61","C45H38ClFN8O9","InChI=1S/C45H38ClFN8O9/c1-62-32-8-4-7-30(47)38(32)40-29-18-24(46)10-12-26(29)39-23(20-50-40)21-51-45(54-39)52-25-11-13-27(34(19-25)63-2)41(58)49-17-5-16-48-36(57)22-64-33-9-3-6-28-37(33)44(61)55(43(28)60)31-14-15-35(56)53-42(31)59/h3-4,6-13,18-19,21,31H,5,14-17,20,22H2,1-2H3,(H,48,57)(H,49,58)(H,51,52,54)(H,53,56,59)","ZSAPKUMUSMSPJX-UHFFFAOYSA-N"
"2043","O14965","AURKA","CRBN","","JB169","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","917.351","916.274730824","5.06","66","8","13","4","16","219.61","C47H42ClFN8O9","InChI=1S/C47H42ClFN8O9/c1-64-34-10-7-9-32(49)40(34)42-31-20-26(48)12-14-28(31)41-25(22-52-42)23-53-47(56-41)54-27-13-15-29(36(21-27)65-2)43(60)51-19-5-3-4-18-50-38(59)24-66-35-11-6-8-30-39(35)46(63)57(45(30)62)33-16-17-37(58)55-44(33)61/h6-15,20-21,23,33H,3-5,16-19,22,24H2,1-2H3,(H,50,59)(H,51,60)(H,53,54,56)(H,55,58,61)","ASENAWSNGBHWMM-UHFFFAOYSA-N"
"2044","O14965","AURKA","CRBN","","JB170","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCOCCOCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","28","","Degradation of AURKA in MV4-11 cells after 6 h treatment","","","","","","","375","ITC","","","","","","","","","","","","","","","6880","ITC","","","","","","","","","","","","","","","183","ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","963.376","962.280210128","3.69","69","8","15","4","19","238.07","C48H44ClFN8O11","InChI=1S/C48H44ClFN8O11/c1-65-35-7-4-6-33(50)41(35)43-32-21-27(49)9-11-29(32)42-26(23-53-43)24-54-48(57-42)55-28-10-12-30(37(22-28)66-2)44(61)52-16-18-68-20-19-67-17-15-51-39(60)25-69-36-8-3-5-31-40(36)47(64)58(46(31)63)34-13-14-38(59)56-45(34)62/h3-12,21-22,24,34H,13-20,23,25H2,1-2H3,(H,51,60)(H,52,61)(H,54,55,57)(H,56,59,62)","GYKNPXCQINZRLL-UHFFFAOYSA-N"
"2045","O14965","AURKA","CRBN","","JB171","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCOCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","919.323","918.25399538","3.84","66","8","14","4","16","228.84","C46H40ClFN8O10","InChI=1S/C46H40ClFN8O10/c1-63-33-7-4-6-31(48)39(33)41-30-19-25(47)9-11-27(30)40-24(21-51-41)22-52-46(55-40)53-26-10-12-28(35(20-26)64-2)42(59)50-16-18-65-17-15-49-37(58)23-66-34-8-3-5-29-38(34)45(62)56(44(29)61)32-13-14-36(57)54-43(32)60/h3-12,19-20,22,32H,13-18,21,23H2,1-2H3,(H,49,58)(H,50,59)(H,52,53,55)(H,54,57,60)","CNOAPBMMLZMAAH-UHFFFAOYSA-N"
"2046","O14965","AURKA","VHL","","JB160","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","1090.676","1089.39855143","6.49","77","8","15","5","21","227.82","C56H61ClFN9O9S","InChI=1S/C56H61ClFN9O9S/c1-32-50(77-31-63-32)34-12-10-33(11-13-34)27-61-53(71)43-26-38(68)30-67(43)54(72)51(56(2,3)4)65-46(69)18-20-75-22-23-76-21-19-59-52(70)40-17-15-37(25-45(40)74-6)64-55-62-29-35-28-60-49(47-42(58)8-7-9-44(47)73-5)41-24-36(57)14-16-39(41)48(35)66-55/h7-17,24-25,29,31,38,43,51,68H,18-23,26-28,30H2,1-6H3,(H,59,70)(H,61,71)(H,65,69)(H,62,64,66)/t38-,43+,51-/m1/s1","IHILQCJMPIODSO-MJGODALBSA-N"
"2047","O14965","AURKA","VHL","","JB161","COC1=CC(NC2=NC=C3CN=C(C4=C(F)C=CC=C4OC)C4=CC(Cl)=CC=C4C3=N2)=CC=C1C(=O)NCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00652-y","1178.782","1177.45098093","6.2","83","8","17","5","27","246.28","C60H69ClFN9O11S","InChI=1S/C60H69ClFN9O11S/c1-36-54(83-35-67-36)38-12-10-37(11-13-38)31-65-57(75)47-30-42(72)34-71(47)58(76)55(60(2,3)4)69-50(73)18-20-79-22-24-81-26-27-82-25-23-80-21-19-63-56(74)44-17-15-41(29-49(44)78-6)68-59-66-33-39-32-64-53(51-46(62)8-7-9-48(51)77-5)45-28-40(61)14-16-43(45)52(39)70-59/h7-17,28-29,33,35,42,47,55,72H,18-27,30-32,34H2,1-6H3,(H,63,74)(H,65,75)(H,69,73)(H,66,68,70)/t42-,47+,55-/m1/s1","DJPBVGROBRCPIN-MDXUJHOYSA-N"
"2048","P15056","BRAF V600E","CRBN","","Pmd-PEG6-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","90","84","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","83","Inhibition of BRAF V600E","","","","","","","","","","","","","","","1180","FP","","","","","","","","","","","","","","","3040","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1133.242","1132.44995961","2.63","80","8","19","3","31","264.28","C54H66F2N10O13S","InChI=1S/C54H66F2N10O13S/c1-3-31-80(72,73)62-42-8-7-40(55)51(49(42)56)65-34-39(36-32-57-35-58-33-36)50-43(65)9-11-45(60-50)63(2)37-13-17-64(18-14-37)47(68)15-19-74-21-23-76-25-27-78-29-30-79-28-26-77-24-22-75-20-16-59-41-6-4-5-38-48(41)54(71)66(53(38)70)44-10-12-46(67)61-52(44)69/h4-9,11,32-35,37,44,59,62H,3,10,12-31H2,1-2H3,(H,61,67,69)","PHBHADRVFSMQAN-UHFFFAOYSA-N"
"2049","P15056","BRAF V600E","CRBN","","Pmd-PEG8-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","45","65","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","85","Inhibition of BRAF V600E","","","","","","","","","","","","","","","1070","FP","","","","","","","","","","","","","","","2980","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1221.348","1220.50238911","2.34","86","8","21","3","37","282.74","C58H74F2N10O15S","InChI=1S/C58H74F2N10O15S/c1-3-35-86(76,77)66-46-8-7-44(59)55(53(46)60)69-38-43(40-36-61-39-62-37-40)54-47(69)9-11-49(64-54)67(2)41-13-17-68(18-14-41)51(72)15-19-78-21-23-80-25-27-82-29-31-84-33-34-85-32-30-83-28-26-81-24-22-79-20-16-63-45-6-4-5-42-52(45)58(75)70(57(42)74)48-10-12-50(71)65-56(48)73/h4-9,11,36-39,41,48,63,66H,3,10,12-35H2,1-2H3,(H,65,71,73)","UGQUDUNSDGAZIO-UHFFFAOYSA-N"
"2050","P15056","BRAF V600E","CRBN","","Pmd-1C-PEG3-1C-2C-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCC(=O)NCCCOCCOCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","100","51","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","82","Inhibition of BRAF V600E","","","","","","","","","","","","","","","1010","FP","","","","","","","","","","","","","","","2460","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1100.216","1099.43972928","3.04","78","8","17","4","27","265.69","C53H63F2N11O11S","InChI=1S/C53H63F2N11O11S/c1-3-29-78(73,74)62-40-10-9-38(54)50(48(40)55)65-32-37(34-30-56-33-57-31-34)49-41(65)11-13-43(60-49)63(2)35-17-21-64(22-18-35)46(69)16-15-44(67)59-20-6-24-76-26-28-77-27-25-75-23-5-19-58-39-8-4-7-36-47(39)53(72)66(52(36)71)42-12-14-45(68)61-51(42)70/h4,7-11,13,30-33,35,42,58,62H,3,5-6,12,14-29H2,1-2H3,(H,59,67)(H,61,68,70)","GVOFKFUVWFBDKE-UHFFFAOYSA-N"
"2051","P15056","BRAF V600E","CRBN","","Pmd-PEG3-3C-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCNC(=O)CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","97","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1036.125","1035.32306552","5.59","72","7","16","5","24","249.24","C48H52F3N9O10S2","InChI=1S/C48H52F3N9O10S2/c1-48(2,3)46-58-40(29-9-5-13-33(39(29)51)59-72(66,67)42-30(49)10-6-11-31(42)50)41(71-46)34-16-20-55-47(56-34)54-19-7-18-53-36(61)17-22-68-24-26-70-27-25-69-23-21-52-32-12-4-8-28-38(32)45(65)60(44(28)64)35-14-15-37(62)57-43(35)63/h4-6,8-13,16,20,35,52,59H,7,14-15,17-19,21-27H2,1-3H3,(H,53,61)(H,54,55,56)(H,57,62,63)","ATHSVXMSBALDKP-UHFFFAOYSA-N"
"2052","P15056","BRAF V600E","CRBN","","Pmd-PEG4-3C-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCNC(=O)CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","122","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1080.178","1079.34928027","5.44","75","7","17","5","27","258.47","C50H56F3N9O11S2","InChI=1S/C50H56F3N9O11S2/c1-50(2,3)48-60-42(31-9-5-13-35(41(31)53)61-75(68,69)44-32(51)10-6-11-33(44)52)43(74-48)36-16-20-57-49(58-36)56-19-7-18-55-38(63)17-22-70-24-26-72-28-29-73-27-25-71-23-21-54-34-12-4-8-30-40(34)47(67)62(46(30)66)37-14-15-39(64)59-45(37)65/h4-6,8-13,16,20,37,54,61H,7,14-15,17-19,21-29H2,1-3H3,(H,55,63)(H,56,57,58)(H,59,64,65)","LPKDZYQNDZPGPP-UHFFFAOYSA-N"
"2053","P15056","BRAF V600E","CRBN","","Pmd-PEG5-3C-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCNC(=O)CCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","99","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1124.231","1123.37549502","5.3","78","7","18","5","30","267.7","C52H60F3N9O12S2","InChI=1S/C52H60F3N9O12S2/c1-52(2,3)50-62-44(33-9-5-13-37(43(33)55)63-78(70,71)46-34(53)10-6-11-35(46)54)45(77-50)38-16-20-59-51(60-38)58-19-7-18-57-40(65)17-22-72-24-26-74-28-30-76-31-29-75-27-25-73-23-21-56-36-12-4-8-32-42(36)49(69)64(48(32)68)39-14-15-41(66)61-47(39)67/h4-6,8-13,16,20,39,56,63H,7,14-15,17-19,21-31H2,1-3H3,(H,57,65)(H,58,59,60)(H,61,66,67)","VIUIPUTXCBUDAQ-UHFFFAOYSA-N"
"2054","P15056","BRAF V600E","CRBN","","Pmd-PEG6-3C-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCNC(=O)CCOCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","199","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1168.284","1167.40170977","5.15","81","7","19","5","33","276.93","C54H64F3N9O13S2","InChI=1S/C54H64F3N9O13S2/c1-54(2,3)52-64-46(35-9-5-13-39(45(35)57)65-81(72,73)48-36(55)10-6-11-37(48)56)47(80-52)40-16-20-61-53(62-40)60-19-7-18-59-42(67)17-22-74-24-26-76-28-30-78-32-33-79-31-29-77-27-25-75-23-21-58-38-12-4-8-34-44(38)51(71)66(50(34)70)41-14-15-43(68)63-49(41)69/h4-6,8-13,16,20,41,58,65H,7,14-15,17-19,21-33H2,1-3H3,(H,59,67)(H,60,61,62)(H,63,68,69)","HLRDXKGGKRYQFI-UHFFFAOYSA-N"
"2055","P15056","BRAF V600E","CRBN","","Pmd-PEG5-PEG5-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCNC(=O)CCOCCOCCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","243","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1415.575","1414.54368254","3.81","98","7","24","6","48","342.95","C65H85F3N10O18S2","InChI=1S/C65H85F3N10O18S2/c1-65(2,3)63-76-57(45-9-5-13-49(56(45)68)77-98(85,86)59-46(66)10-6-11-47(59)67)58(97-63)50-16-21-73-64(74-50)72-20-7-19-70-52(79)17-24-87-28-32-91-36-40-96-43-39-94-35-31-90-27-23-71-53(80)18-25-88-29-33-92-37-41-95-42-38-93-34-30-89-26-22-69-48-12-4-8-44-55(48)62(84)78(61(44)83)51-14-15-54(81)75-60(51)82/h4-6,8-13,16,21,51,69,77H,7,14-15,17-20,22-43H2,1-3H3,(H,70,79)(H,71,80)(H,72,73,74)(H,75,81,82)","CFJXGSRNSVSOHS-UHFFFAOYSA-N"
"2056","P15056","BRAF V600E","CRBN","","Thd-1C-6C-Dab#1","CC(C)(C)C1=NC(C2=CC=CC(NS(=O)(=O)C3=C(F)C=CC=C3F)=C2F)=C(C2=CC=NC(NCCCCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=N2)S1","","","","","","51","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","933.004","932.259736996","6.09","65","7","13","4","17","218.75","C44H43F3N8O8S2","InChI=1S/C44H43F3N8O8S2/c1-44(2,3)42-53-36(25-12-8-15-28(35(25)47)54-65(61,62)38-26(45)13-10-14-27(38)46)37(64-42)29-19-22-50-43(51-29)49-21-7-5-4-6-20-48-33(57)23-63-31-16-9-11-24-34(31)41(60)55(40(24)59)30-17-18-32(56)52-39(30)58/h8-16,19,22,30,54H,4-7,17-18,20-21,23H2,1-3H3,(H,48,57)(H,49,50,51)(H,52,56,58)","ITVNFYFULVBJMW-UHFFFAOYSA-N"
"2057","P15056","BRAF V600E","VHL","","VH-2C-6C-Dab#1","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](NC(=O)CCC(=O)NCCCCCCNC3=NC=CC(C4=C(C5=CC=CC(NS(=O)(=O)C6=C(F)C=CC=C6F)=C5F)N=C(C(C)(C)C)S4)=N3)C(C)(C)C)C=C2)SC=N1","","","","","","73","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1131.383","1130.41519208","8.14","78","7","14","6","22","237.6","C55H65F3N10O7S3","InChI=1S/C55H65F3N10O7S3/c1-32-46(76-31-63-32)34-20-18-33(19-21-34)29-62-50(72)41-28-35(69)30-68(41)51(73)49(54(2,3)4)65-43(71)23-22-42(70)59-25-10-8-9-11-26-60-53-61-27-24-40(64-53)47-45(66-52(77-47)55(5,6)7)36-14-12-17-39(44(36)58)67-78(74,75)48-37(56)15-13-16-38(48)57/h12-21,24,27,31,35,41,49,67,69H,8-11,22-23,25-26,28-30H2,1-7H3,(H,59,70)(H,62,72)(H,65,71)(H,60,61,64)/t35-,41+,49+/m1/s1","XIEAIGUZMCJELK-YZDWGWATSA-N"
"2058","P15056","BRAF V600E","VHL","","VH-PEG4-Dab#2","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCC(=O)N3CCC(C4=NC(C5=CC=CC(NS(=O)(=O)C6=C(F)C=CC=C6F)=C5F)=C(C5=CC=NC(N)=N5)S4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","58","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1235.444","1234.42615069","4.5","85","8","18","5","27","279.72","C58H69F3N10O11S3","InChI=1S/C58H69F3N10O11S3/c1-35-50(83-34-65-35)37-13-11-36(12-14-37)32-64-54(75)45-31-39(72)33-71(45)56(76)53(58(2,3)4)67-46(73)18-23-79-25-27-81-29-30-82-28-26-80-24-19-47(74)70-21-16-38(17-22-70)55-68-49(51(84-55)44-15-20-63-57(62)66-44)40-7-5-10-43(48(40)61)69-85(77,78)52-41(59)8-6-9-42(52)60/h5-15,20,34,38-39,45,53,69,72H,16-19,21-33H2,1-4H3,(H,64,75)(H,67,73)(H2,62,63,66)/t39-,45+,53-/m1/s1","VUMUBHDKMLAWJK-MPSVZJIXSA-N"
"2059","P15056","BRAF V600E","CRBN","","Pmd-PEG3-Dab#2","NC1=NC=CC(C2=C(C3=CC=CC(NS(=O)(=O)C4=C(F)C=CC=C4F)=C3F)N=C(C3CCN(C(=O)CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)S2)=N1","500","50","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","26","Inhibition of BRAF V600E","","","2.6","SPR","","","","","","","1.8","0.4","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1006.055","1005.27611533","3.07","70","8","16","4","20","254.44","C46H46F3N9O10S2","InChI=1S/C46H46F3N9O10S2/c47-29-6-3-7-30(48)41(29)70(64,65)56-32-9-2-5-28(38(32)49)39-40(33-12-16-52-46(50)53-33)69-43(55-39)26-13-18-57(19-14-26)36(60)15-20-66-22-24-68-25-23-67-21-17-51-31-8-1-4-27-37(31)45(63)58(44(27)62)34-10-11-35(59)54-42(34)61/h1-9,12,16,26,34,51,56H,10-11,13-15,17-25H2,(H2,50,52,53)(H,54,59,61)","TTXCLAHYGSGCRI-UHFFFAOYSA-N"
"2060","P15056","BRAF V600E","CRBN","","Pmd-PEG3-Az-C1-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(CC5CN(C(=O)CCOCCOCCOCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)CC4)=CC=C32)=C1F","","N.D.","","","","2","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1070.19","1069.42916459","3.15","76","9","17","3","24","239.83","C52H61F2N11O10S","InChI=1S/C52H61F2N11O10S/c1-3-25-76(71,72)60-40-8-7-38(53)49(47(40)54)64-31-37(34-26-55-32-56-27-34)48-41(64)9-11-43(58-48)61(2)35-13-17-62(18-14-35)28-33-29-63(30-33)45(67)15-19-73-21-23-75-24-22-74-20-16-57-39-6-4-5-36-46(39)52(70)65(51(36)69)42-10-12-44(66)59-50(42)68/h4-9,11,26-27,31-33,35,42,57,60H,3,10,12-25,28-30H2,1-2H3,(H,59,66,68)","LCDUHYBKQVDAET-UHFFFAOYSA-N"
"2061","P15056","BRAF V600E","CRBN","","Pmd-C1-Ph-C1-PPZ-C9-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(CCCCCCCCCC(=O)N5CCN(CC6=CC=C(CNC7=CC=CC8=C7C(=O)N(C7CCC(=O)NC7=O)C8=O)C=C6)CC5)CC4)=CC=C32)=C1F","","N.D.","","","","33","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1155.387","1154.53357008","7.9","83","10","15","3","24","215.38","C61H72F2N12O7S","InChI=1S/C61H72F2N12O7S/c1-3-34-83(81,82)69-49-20-19-47(62)58(56(49)63)74-39-46(43-36-64-40-65-37-43)57-50(74)21-23-52(67-57)70(2)44-25-28-71(29-26-44)27-10-8-6-4-5-7-9-14-54(77)73-32-30-72(31-33-73)38-42-17-15-41(16-18-42)35-66-48-13-11-12-45-55(48)61(80)75(60(45)79)51-22-24-53(76)68-59(51)78/h11-13,15-21,23,36-37,39-40,44,51,66,69H,3-10,14,22,24-35,38H2,1-2H3,(H,68,76,78)","CKYMSWCSFSXJQJ-UHFFFAOYSA-N"
"2062","P15056","BRAF V600E","CRBN","","Pmd-PPZ-C9-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(CCCCCCCCCC(=O)N5CCN(C6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)=CC=C32)=C1F","","N.D.","","","","3","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1036.22","1035.4600708","6.16","74","9","14","2","20","203.35","C53H63F2N11O7S","InChI=1S/C53H63F2N11O7S/c1-3-30-74(72,73)60-40-16-15-39(54)50(48(40)55)65-33-38(35-31-56-34-57-32-35)49-42(65)17-19-44(58-49)61(2)36-21-24-62(25-22-36)23-10-8-6-4-5-7-9-14-46(68)64-28-26-63(27-29-64)41-13-11-12-37-47(41)53(71)66(52(37)70)43-18-20-45(67)59-51(43)69/h11-13,15-17,19,31-34,36,43,60H,3-10,14,18,20-30H2,1-2H3,(H,59,67,69)","KHDFCYGRSVDYNO-UHFFFAOYSA-N"
"2063","P15056","BRAF V600E","CRBN","","Pmd-DODA-C1-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(CC(=O)NCCCOCCCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","25","71","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","25","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1042.18","1041.43424997","4.61","74","8","16","4","25","239.39","C51H61F2N11O9S","InChI=1S/C51H61F2N11O9S/c1-3-27-74(70,71)60-39-12-11-37(52)48(46(39)53)63-30-36(33-28-54-32-55-29-33)47-40(63)13-15-42(58-47)61(2)34-17-21-62(22-18-34)31-44(66)57-20-8-26-73-24-5-4-23-72-25-7-19-56-38-10-6-9-35-45(38)51(69)64(50(35)68)41-14-16-43(65)59-49(41)67/h6,9-13,15,28-30,32,34,41,56,60H,3-5,7-8,14,16-27,31H2,1-2H3,(H,57,66)(H,59,65,67)","DAQQIWJQNSGFLU-UHFFFAOYSA-N"
"2064","P15056","BRAF V600E","CRBN","","Pmd-PEG1-Trz-PEG2-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCN5C=C(COCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)N=N5)CC4)=CC=C32)=C1F","80","72","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","15","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1082.161","1081.40401246","2.31","77","9","19","3","24","267.3","C51H57F2N13O10S","InChI=1S/C51H57F2N13O10S/c1-3-25-77(72,73)60-39-8-7-37(52)48(46(39)53)65-29-36(32-26-54-31-55-27-32)47-40(65)9-11-42(57-47)62(2)34-13-17-63(18-14-34)44(68)15-20-74-23-24-75-22-19-64-28-33(59-61-64)30-76-21-16-56-38-6-4-5-35-45(38)51(71)66(50(35)70)41-10-12-43(67)58-49(41)69/h4-9,11,26-29,31,34,41,56,60H,3,10,12-25,30H2,1-2H3,(H,58,67,69)","VFSRJJPNEQKSQQ-UHFFFAOYSA-N"
"2065","P15056","BRAF V600E","CRBN","","Len(C)PEG4-BI","CCCS(=O)(=O)NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C3=NC(N(C)C4CCN(C(=O)CCOCCOCCOCCOCC#CC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C32)=C1F","50","74","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","90","Inhibition of BRAF V600E","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-0609-7","1026.133","1025.39171646","2.64","73","8","15","2","22","216.72","C51H57F2N9O10S","InChI=1S/C51H57F2N9O10S/c1-3-28-73(67,68)58-41-10-9-40(52)49(47(41)53)61-32-39(35-29-54-33-55-30-35)48-42(61)11-13-44(56-48)59(2)36-15-18-60(19-16-36)46(64)17-21-70-23-25-72-27-26-71-24-22-69-20-5-7-34-6-4-8-37-38(34)31-62(51(37)66)43-12-14-45(63)57-50(43)65/h4,6,8-11,13,29-30,32-33,36,43,58H,3,12,14-28,31H2,1-2H3,(H,57,63,65)","OURGGRRMESLKOS-UHFFFAOYSA-N"
"2066","Q06187","BTK","cIAP1","","BC2P","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOC(=O)N3CCC[C@@H](N4N=C(C5=CC=C(OC6=CC=C(F)C=C6F)C=C5)C(C(N)=O)=C4N)C3)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00686-2","1048.202","1047.50298116","6.68","76","8","13","5","18","234.7","C56H67F2N9O9","InChI=1S/C56H67F2N9O9/c1-33(61-5)52(69)63-49(56(2,3)4)54(71)66-31-37-28-41(21-17-36(37)29-45(66)53(70)62-44-14-8-11-34-10-6-7-13-42(34)44)74-26-24-73-25-27-75-55(72)65-23-9-12-39(32-65)67-50(59)47(51(60)68)48(64-67)35-15-19-40(20-16-35)76-46-22-18-38(57)30-43(46)58/h6-7,10,13,15-22,28,30,33,39,44-45,49,61H,8-9,11-12,14,23-27,29,31-32,59H2,1-5H3,(H2,60,68)(H,62,70)(H,63,69)/t33-,39+,44+,45-,49+/m0/s1","UGRJNHBWVKZNEV-YMMKHCTOSA-N"
"2067","Q06187","BTK","cIAP1","6W7O","BCPyr","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCC3=CN=C(COC(=O)N4CCC[C@@H](N5N=C(C6=CC=C(OC7=CC=C(F)C=C7F)C=C6)C(C(N)=O)=C5N)C4)C=N3)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","800","","Degradation of BTK in THP-1 cells","","","","","","","692","BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","262","BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00686-2","1082.223","1081.49856448","6.05","79","9","14","5","16","251.25","C58H65F2N11O8","InChI=1S/C58H65F2N11O8/c1-33(63-5)54(73)67-51(58(2,3)4)56(75)70-29-37-24-43(21-17-36(37)25-47(70)55(74)66-46-14-8-11-34-10-6-7-13-44(34)46)77-31-39-27-65-40(28-64-39)32-78-57(76)69-23-9-12-41(30-69)71-52(61)49(53(62)72)50(68-71)35-15-19-42(20-16-35)79-48-22-18-38(59)26-45(48)60/h6-7,10,13,15-22,24,26-28,33,41,46-47,51,63H,8-9,11-12,14,23,25,29-32,61H2,1-5H3,(H2,62,72)(H,66,74)(H,67,73)/t33-,41+,46+,47-,51+/m0/s1","PTEVOZUKHQQUNI-DLUJOBAXSA-N"
"2068","Q06187","BTK","IAP","","BCPip","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(CCCC(=O)N2CCC[C@@H](N3N=C(C4=CC=C(OC5=CC=C(F)C=C5F)C=C4)C(C(N)=O)=C3N)C2)CC1","4700","","Degradation of BTK in THP-1 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13750","BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-020-00686-2","983.131","982.413535204","5.47","70","8","13","4","17","211.11","C50H57F3N10O6S","InChI=1S/C50H57F3N10O6S/c1-29(56-2)48(67)58-44(50(68)62-23-4-7-39(62)49-57-38(28-70-49)45(65)32-9-13-33(51)14-10-32)31-19-24-60(25-20-31)21-5-8-41(64)61-22-3-6-35(27-61)63-46(54)42(47(55)66)43(59-63)30-11-16-36(17-12-30)69-40-18-15-34(52)26-37(40)53/h9-18,26,28-29,31,35,39,44,56H,3-8,19-25,27,54H2,1-2H3,(H2,55,66)(H,58,67)/t29-,35+,39-,44-/m0/s1","AAKFJWJWMSEXFZ-MKGGXPFMSA-N"
"2069","P24941","CDK2","CRBN","","CPF1","NC1=NC(NC2=CC=C(S(=O)(=O)NCCOCC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C=C2)=NN1C(=O)C1=C(F)C=CC=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","862.833","862.241698172","2.16","61","7","18","5","18","276.75","C37H36F2N12O9S","InChI=1S/C37H36F2N12O9S/c38-25-4-2-5-26(39)31(25)35(56)51-36(40)45-37(47-51)43-21-7-9-23(10-8-21)61(57,58)42-14-17-60-20-22-19-49(48-46-22)15-18-59-16-13-41-27-6-1-3-24-30(27)34(55)50(33(24)54)28-11-12-29(52)44-32(28)53/h1-10,19,28,41-42H,11-18,20H2,(H,44,52,53)(H3,40,43,45,47)","NPIOYTVJPIMYFJ-UHFFFAOYSA-N"
"2070","P24941","CDK2","CRBN","","CPS1","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","846.909","846.232612796","2.34","59","7","19","5","18","276.75","C36H38N12O9S2","InChI=1S/C36H38N12O9S2/c1-21-11-18-58-30(21)34(53)48-35(37)42-36(44-48)40-22-5-7-24(8-6-22)59(54,55)39-13-16-57-20-23-19-46(45-43-23)14-17-56-15-12-38-26-4-2-3-25-29(26)33(52)47(32(25)51)27-9-10-28(49)41-31(27)50/h2-8,11,18-19,27,38-39H,9-10,12-17,20H2,1H3,(H,41,49,50)(H3,37,40,42,44)","XDXJPYFXKLUQND-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","160/4/9","","Degradation of CDK2 in Pfeiffer/DOHH2/K562 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","22/8","","Degradation of CDK2 in MM.1S/MDA-MB-231 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","38/53/11","","Degradation of CDK2 in Jurkat/MOLT-4/U937 cells after 48 h treatment","","","24","Inhibition of CDK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","43/33/29","","Degradation of CDK2 in Z138/HBL-1/Mino cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","56/13/18","","Degradation of CDK2 in OCI-AML2/OCI-AML3/Ramos cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2071","P24941","CDK2","CRBN","","CPS2","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","61/12/1","","Degradation of CDK2 in Kasumi-1/NB4/MV-4-11 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","890.962","890.258827544","2.19","62","7","20","5","21","285.98","C38H42N12O10S2","InChI=1S/C38H42N12O10S2/c1-23-11-20-61-32(23)36(55)50-37(39)44-38(46-50)42-24-5-7-26(8-6-24)62(56,57)41-13-16-60-22-25-21-48(47-45-25)14-17-59-19-18-58-15-12-40-28-4-2-3-27-31(28)35(54)49(34(27)53)29-9-10-30(51)43-33(29)52/h2-8,11,20-21,29,40-41H,9-10,12-19,22H2,1H3,(H,43,51,52)(H3,39,42,44,46)","BXCPYBFBMAWDDY-UHFFFAOYSA-N"
"2072","P24941","CDK2","CRBN","","CPS3","CC1=C(C(=O)N2N=C(NC3=CC=C(S(=O)(=O)NCCOCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)N=C2N)SC=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00742-5","935.015","934.285042292","2.04","65","7","21","5","24","295.21","C40H46N12O11S2","InChI=1S/C40H46N12O11S2/c1-25-11-22-64-34(25)38(57)52-39(41)46-40(48-52)44-26-5-7-28(8-6-26)65(58,59)43-13-16-63-24-27-23-50(49-47-27)14-17-61-19-21-62-20-18-60-15-12-42-30-4-2-3-29-33(30)37(56)51(36(29)55)31-9-10-32(53)45-35(31)54/h2-8,11,22-23,31,42-43H,9-10,12-21,24H2,1H3,(H,45,53,54)(H3,41,44,46,48)","QCGIJQUINCKXHY-UHFFFAOYSA-N"
"2073","P15056","BRAF V600K","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","","","","","","0.49","IC50 was assessed by radio labeled kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF K601E","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","","","","","","7.84","IC50 was assessed by radio labeled kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF G466E","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF D594N","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","","","","","","5.8/39.2","IC50 was assessed by radio labeled kinase assay/Elisa Kinase inhibition Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF G466V","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","29/23","80/90","Degradation of BRAF G466V in H1666/CAL-12T cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF G469A","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","15","95","Degradation of BRAF G469A in SK-MEL-246 cells","","","0.98","IC50 was assessed by radio labeled kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45","Inhibit growth of SK-MEL-246 cells","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
"2073","P15056","BRAF V600E","VHL","","SJF-0628","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)C=C23)=C1F","6.8","95","Degradation of BRAF V600E in SK-MEL-28 cells","","","1.87/24.4","IC50 was assessed by radio labeled kinase assay/Elisa Kinase inhibition Assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","37/218","Inhibit growth of SK-MEL-28/SK-MEL-239 C4 cells","","","","","","","","","","","","","10.1038/s41467-021-21159-7","1010.203","1009.3790436","6.39","71","8","12","5","16","210.03","C51H57F2N9O7S2","InChI=1S/C51H57F2N9O7S2/c1-6-21-71(68,69)59-40-16-15-39(52)43(44(40)53)45(65)38-26-55-48-37(38)22-34(25-54-48)32-11-13-35(14-12-32)61-19-17-60(18-20-61)28-42(64)58-47(51(3,4)5)50(67)62-27-36(63)23-41(62)49(66)56-24-31-7-9-33(10-8-31)46-30(2)57-29-70-46/h7-16,22,25-26,29,36,41,47,59,63H,6,17-21,23-24,27-28H2,1-5H3,(H,54,55)(H,56,66)(H,58,64)/t36-,41+,47-/m1/s1","MBCAVOCJJAQHHT-FGUOTCRGSA-N"
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"2074","P15056","BRAF V600K","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
"2074","P15056","BRAF K601E","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
"2074","P15056","BRAF G469A","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
"2074","P15056","BRAF G466E","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
"2074","P15056","BRAF D594N","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
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"2074","P15056","BRAF","VHL","","SJF-4604","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","970.134","969.336510096","6.69","68","7","11","5","18","212.78","C49H53F2N7O8S2","InChI=1S/C49H53F2N7O8S2/c1-6-20-68(64,65)57-38-18-17-37(50)41(42(38)51)43(61)36-25-53-46-35(36)21-32(24-52-46)30-13-15-34(16-14-30)66-19-7-8-40(60)56-45(49(3,4)5)48(63)58-26-33(59)22-39(58)47(62)54-23-29-9-11-31(12-10-29)44-28(2)55-27-67-44/h9-18,21,24-25,27,33,39,45,57,59H,6-8,19-20,22-23,26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JAXNJXHPVRNGIK-MDBCNMMHSA-N"
"2075","P15056","BRAF V600E","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF V600K","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF K601E","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF G469A","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF G466E","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF D594N","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF G466V","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2075","P15056","BRAF","VHL","","SJF-8090","CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(OCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)C=C4)C=C23)=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-21159-7","986.133","985.331424716","6.28","69","7","12","5","19","222.01","C49H53F2N7O9S2","InChI=1S/C49H53F2N7O9S2/c1-6-19-69(64,65)57-38-16-15-37(50)41(42(38)51)43(61)36-24-53-46-35(36)20-32(23-52-46)30-11-13-34(14-12-30)67-18-17-66-26-40(60)56-45(49(3,4)5)48(63)58-25-33(59)21-39(58)47(62)54-22-29-7-9-31(10-8-29)44-28(2)55-27-68-44/h7-16,20,23-24,27,33,39,45,57,59H,6,17-19,21-22,25-26H2,1-5H3,(H,52,53)(H,54,62)(H,56,60)/t33-,39+,45-/m1/s1","JKSNWKGGBKCFAX-MDBCNMMHSA-N"
"2076","Q06187","BTK","CRBN","","","CN(CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","6.6","","Degradation of BTK in MOLM-14 cells after 24 h treatment","","","43","Target Engagement IC50 was assessed by NanoBRET assay","","","6.4","Kd was assessed by Eurofins DiscoverX","","","","","","","","","","","250","Target Engagement IC50 was assessed by NanoBRET assay","","","4214","Kd was assessed based on fluorescence quenching after compounds binding to CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","309/82","Inhibit viability of MOLM-14/Mino cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","907.005","906.39254194","3.93","67","8","15","4","15","250.87","C48H50N12O7","InChI=1S/C48H50N12O7/c1-48(2,57(3)22-9-21-51-38(62)26-52-35-14-7-13-34-39(35)47(66)59(46(34)65)36-19-20-37(61)55-44(36)63)24-30(25-49)45(64)58-23-8-10-31(27-58)60-43-40(42(50)53-28-54-43)41(56-60)29-15-17-33(18-16-29)67-32-11-5-4-6-12-32/h4-7,11-18,24,28,31,36,52H,8-10,19-23,26-27H2,1-3H3,(H,51,62)(H2,50,53,54)(H,55,61,63)/b30-24+/t31-,36?/m1/s1","TXZDWTVEZQSZKM-ZLCUCVQPSA-N"
"2077","Q06187","BTK","CRBN","","","CN(CCCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","551","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","921.032","920.408192004","4.29","68","8","15","4","16","250.87","C49H52N12O7","InChI=1S/C49H52N12O7/c1-49(2,58(3)23-8-7-22-52-39(63)27-53-36-15-9-14-35-40(36)48(67)60(47(35)66)37-20-21-38(62)56-45(37)64)25-31(26-50)46(65)59-24-10-11-32(28-59)61-44-41(43(51)54-29-55-44)42(57-61)30-16-18-34(19-17-30)68-33-12-5-4-6-13-33/h4-6,9,12-19,25,29,32,37,53H,7-8,10-11,20-24,27-28H2,1-3H3,(H,52,63)(H2,51,54,55)(H,56,62,64)/b31-25+/t32-,37?/m1/s1","GQMXYTKNDPYNAM-MRRWVVGWSA-N"
"2078","Q06187","BTK","CRBN","","","CN(CCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","344","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","937.031","936.403106624","3.43","69","8","16","4","17","260.1","C49H52N12O8","InChI=1S/C49H52N12O8/c1-49(2,58(3)22-24-68-23-20-52-39(63)27-53-36-13-7-12-35-40(36)48(67)60(47(35)66)37-18-19-38(62)56-45(37)64)25-31(26-50)46(65)59-21-8-9-32(28-59)61-44-41(43(51)54-29-55-44)42(57-61)30-14-16-34(17-15-30)69-33-10-5-4-6-11-33/h4-7,10-17,25,29,32,37,53H,8-9,18-24,27-28H2,1-3H3,(H,52,63)(H2,51,54,55)(H,56,62,64)/b31-25+/t32-,37?/m1/s1","BIWWDWYZABUYOP-MRRWVVGWSA-N"
"2079","Q06187","BTK","CRBN","","RC-4","CN(CCOCCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","628","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","981.084","980.429321372","3.28","72","8","17","4","20","269.33","C51H56N12O9","InChI=1S/C51H56N12O9/c1-51(2,60(3)22-24-71-26-25-70-23-20-54-41(65)29-55-38-13-7-12-37-42(38)50(69)62(49(37)68)39-18-19-40(64)58-47(39)66)27-33(28-52)48(67)61-21-8-9-34(30-61)63-46-43(45(53)56-31-57-46)44(59-63)32-14-16-36(17-15-32)72-35-10-5-4-6-11-35/h4-7,10-17,27,31,34,39,55H,8-9,18-26,29-30H2,1-3H3,(H,54,65)(H2,53,56,57)(H,58,64,66)/b33-27+/t34-,39?/m1/s1","BWYAUYKRNMEXKD-JJKWERHXSA-N"
"2080","Q06187","BTK","CRBN","","RC-5","CN(CCOCCOCCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","765","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","1025.137","1024.45553612","3.13","75","8","18","4","23","278.56","C53H60N12O10","InChI=1S/C53H60N12O10/c1-53(2,29-35(30-54)50(69)63-21-8-9-36(32-63)65-48-45(47(55)58-33-59-48)46(61-65)34-14-16-38(17-15-34)75-37-10-5-4-6-11-37)62(3)22-24-73-26-28-74-27-25-72-23-20-56-43(67)31-57-40-13-7-12-39-44(40)52(71)64(51(39)70)41-18-19-42(66)60-49(41)68/h4-7,10-17,29,33,36,41,57H,8-9,18-28,31-32H2,1-3H3,(H,56,67)(H2,55,58,59)(H,60,66,68)/b35-29+/t36-,41?/m1/s1","SAFAAAUXPIIDAP-CJDLBDMNSA-N"
"2081","Q06187","BTK","CRBN","","RC-6","CN(CCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","892.978","892.376891876","3.57","66","8","15","4","14","250.87","C47H48N12O7","InChI=1S/C47H48N12O7/c1-47(2,56(3)22-20-50-37(61)25-51-34-13-7-12-33-38(34)46(65)58(45(33)64)35-18-19-36(60)54-43(35)62)23-29(24-48)44(63)57-21-8-9-30(26-57)59-42-39(41(49)52-27-53-42)40(55-59)28-14-16-32(17-15-28)66-31-10-5-4-6-11-31/h4-7,10-17,23,27,30,35,51H,8-9,18-22,25-26H2,1-3H3,(H,50,61)(H2,49,52,53)(H,54,60,62)/b29-23+/t30-,35?/m1/s1","ODLVHKLFZMULIA-UJJYFZJBSA-N"
"2082","Q06187","BTK","CRBN","","RC-7","CN(CCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1351","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","863.98","863.386728288","4.94","64","8","14","3","14","221.77","C47H49N11O6","InChI=1S/C47H49N11O6/c1-47(2,55(3)23-8-7-22-50-35-15-9-14-34-38(35)46(63)57(45(34)62)36-20-21-37(59)53-43(36)60)25-30(26-48)44(61)56-24-10-11-31(27-56)58-42-39(41(49)51-28-52-42)40(54-58)29-16-18-33(19-17-29)64-32-12-5-4-6-13-32/h4-6,9,12-19,25,28,31,36,50H,7-8,10-11,20-24,27H2,1-3H3,(H2,49,51,52)(H,53,59,60)/b30-25+/t31-,36?/m1/s1","XZNMJSXBLFMCHZ-UUDKYUENSA-N"
"2083","Q06187","BTK","CRBN","","RC-8","CN(CCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2424","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","849.953","849.371078224","4.59","63","8","14","3","13","221.77","C46H47N11O6","InChI=1S/C46H47N11O6/c1-46(2,54(3)22-9-21-49-34-14-7-13-33-37(34)45(62)56(44(33)61)35-19-20-36(58)52-42(35)59)24-29(25-47)43(60)55-23-8-10-30(26-55)57-41-38(40(48)50-27-51-41)39(53-57)28-15-17-32(18-16-28)63-31-11-5-4-6-12-31/h4-7,11-18,24,27,30,35,49H,8-10,19-23,26H2,1-3H3,(H2,48,50,51)(H,52,58,59)/b29-24+/t30-,35?/m1/s1","HODNTCWUJMAAND-AMUKRWIYSA-N"
"2084","Q06187","BTK","CRBN","","RC-9","CN(CCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","364","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","907.989","907.376557528","3.37","67","8","15","3","15","248.07","C48H49N11O8","InChI=1S/C48H49N11O8/c1-48(2,56(3)22-9-21-51-38(61)27-66-36-14-7-13-34-39(36)47(65)58(46(34)64)35-19-20-37(60)54-44(35)62)24-30(25-49)45(63)57-23-8-10-31(26-57)59-43-40(42(50)52-28-53-43)41(55-59)29-15-17-33(18-16-29)67-32-11-5-4-6-12-32/h4-7,11-18,24,28,31,35H,8-10,19-23,26-27H2,1-3H3,(H,51,61)(H2,50,52,53)(H,54,60,62)/b30-24+/t31-,35?/m1/s1","AQFKXPHYJGPMRE-SQFDJQBRSA-N"
"2085","Q06187","BTK","CRBN","","IRC-1","CN(C/C=C/C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1)CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","130","Target Engagement IC50 was assessed by NanoBRET assay","","","3","Kd was assessed by Eurofins DiscoverX","","","","","","","","","","","860","Target Engagement IC50 was assessed by NanoBRET assay","","","1530","Kd was assessed based on fluorescence quenching after compounds binding to CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","2700/195","Inhibit viability of MOLM-14/Mino cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","853.941","853.365992844","3.41","63","8","14","4","15","227.08","C45H47N11O7","InChI=1S/C45H47N11O7/c1-53(23-8-21-47-36(58)25-48-33-13-5-12-32-38(33)45(62)55(44(32)61)34-19-20-35(57)51-43(34)60)22-7-14-37(59)54-24-6-9-29(26-54)56-42-39(41(46)49-27-50-42)40(52-56)28-15-17-31(18-16-28)63-30-10-3-2-4-11-30/h2-5,7,10-18,27,29,34,48H,6,8-9,19-26H2,1H3,(H,47,58)(H2,46,49,50)(H,51,57,60)/b14-7+/t29-,34?/m1/s1","PKUDGIDHOCLKDL-ALNTYYASSA-N"
"2086","Q06187","BTK","CRBN","","RNC-1","CN(CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)CCCC(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","1270","Target Engagement IC50 was assessed by NanoBRET assay","","","4.7","Kd was assessed by Eurofins DiscoverX","","","","","","","","","","","1690","Target Engagement IC50 was assessed by NanoBRET assay","","","1801","Kd was assessed based on fluorescence quenching after compounds binding to CRBN","","","","","","","","","","","","","","","","","","","","","","","","","","","4134/1017","Inhibit viability of MOLM-14/Mino cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","855.957","855.381642908","3.45","63","8","14","4","16","227.08","C45H49N11O7","InChI=1S/C45H49N11O7/c1-53(23-8-21-47-36(58)25-48-33-13-5-12-32-38(33)45(62)55(44(32)61)34-19-20-35(57)51-43(34)60)22-7-14-37(59)54-24-6-9-29(26-54)56-42-39(41(46)49-27-50-42)40(52-56)28-15-17-31(18-16-28)63-30-10-3-2-4-11-30/h2-5,10-13,15-18,27,29,34,48H,6-9,14,19-26H2,1H3,(H,47,58)(H2,46,49,50)(H,51,57,60)/t29-,34?/m1/s1","GFVDQUVKROMDKX-QMUARQKKSA-N"
"2087","Q06187","BTK","CRBN","","IRC-3","CN(C/C=C/C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1)CCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7225","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","883.967","883.376557528","2.91","65","8","15","4","17","236.31","C46H49N11O8","InChI=1S/C46H49N11O8/c1-54(23-25-64-24-20-48-37(59)26-49-34-12-5-11-33-39(34)46(63)56(45(33)62)35-18-19-36(58)52-44(35)61)21-7-13-38(60)55-22-6-8-30(27-55)57-43-40(42(47)50-28-51-43)41(53-57)29-14-16-32(17-15-29)65-31-9-3-2-4-10-31/h2-5,7,9-17,28,30,35,49H,6,8,18-27H2,1H3,(H,48,59)(H2,47,50,51)(H,52,58,61)/b13-7+/t30-,35?/m1/s1","YEEPDGOQODODMO-XMMXAIJBSA-N"
"2088","Q06187","BTK","CRBN","","RNC-3","CN(CCCC(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1)CCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9279","Inhibit viability of MOLM-14 cells","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","885.983","885.392207592","2.94","65","8","15","4","18","236.31","C46H51N11O8","InChI=1S/C46H51N11O8/c1-54(23-25-64-24-20-48-37(59)26-49-34-12-5-11-33-39(34)46(63)56(45(33)62)35-18-19-36(58)52-44(35)61)21-7-13-38(60)55-22-6-8-30(27-55)57-43-40(42(47)50-28-51-43)41(53-57)29-14-16-32(17-15-29)65-31-9-3-2-4-10-31/h2-5,9-12,14-17,28,30,35,49H,6-8,13,18-27H2,1H3,(H,48,59)(H2,47,50,51)(H,52,58,61)/t30-,35?/m1/s1","ZTZMMPYSFYAYEN-OSRRZMJMSA-N"
"2089","Q06187","BTK","CRBN","","RNC-1-CN-DiMe","CN(CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)CC(C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","930","Target Engagement IC50 was assessed by NanoBRET assay","","","29","Kd was assessed by Eurofins DiscoverX","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","909.021","908.408192004","4.05","67","8","15","4","16","250.87","C48H52N12O7","InChI=1S/C48H52N12O7/c1-48(2,57(3)22-9-21-51-38(62)26-52-35-14-7-13-34-39(35)47(66)59(46(34)65)36-19-20-37(61)55-44(36)63)24-30(25-49)45(64)58-23-8-10-31(27-58)60-43-40(42(50)53-28-54-43)41(56-60)29-15-17-33(18-16-29)67-32-11-5-4-6-12-32/h4-7,11-18,28,30-31,36,52H,8-10,19-24,26-27H2,1-3H3,(H,51,62)(H2,50,53,54)(H,55,61,63)/t30?,31-,36?/m1/s1","PHAZJTZLXOUEHA-RDAJPIIQSA-N"
"2090","Q06187","BTK","CRBN","","IRC-1-DiMe","CN(CCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C/C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","380","Target Engagement IC50 was assessed by NanoBRET assay","","","11","Kd was assessed by Eurofins DiscoverX","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","881.995","881.397292972","4.0","65","8","14","4","15","227.08","C47H51N11O7","InChI=1S/C47H51N11O7/c1-47(2,55(3)24-9-23-49-37(60)26-50-34-14-7-13-33-39(34)46(64)57(45(33)63)35-19-20-36(59)53-44(35)62)22-21-38(61)56-25-8-10-30(27-56)58-43-40(42(48)51-28-52-43)41(54-58)29-15-17-32(18-16-29)65-31-11-5-4-6-12-31/h4-7,11-18,21-22,28,30,35,50H,8-10,19-20,23-27H2,1-3H3,(H,49,60)(H2,48,51,52)(H,53,59,62)/b22-21+/t30-,35?/m1/s1","PIADEZHQUYWJMS-BZCHBZHKSA-N"
"2091","Q06187","BTK","CRBN","","IRC-10","CN(C/C=C/C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1)CCOCCNC(=O)CNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","883.967","883.376557528","2.36","65","8","15","4","17","236.31","C46H49N11O8","InChI=1S/C46H49N11O8/c1-54(22-24-64-23-19-48-38(59)26-49-30-13-16-34-35(25-30)46(63)56(45(34)62)36-17-18-37(58)52-44(36)61)20-6-10-39(60)55-21-5-7-31(27-55)57-43-40(42(47)50-28-51-43)41(53-57)29-11-14-33(15-12-29)65-32-8-3-2-4-9-32/h2-4,6,8-16,25,28,31,36,49H,5,7,17-24,26-27H2,1H3,(H,48,59)(H2,47,50,51)(H,52,58,61)/b10-6+/t31-,36?/m1/s1","CQHUMQBDGCHBTM-KSZXAHAJSA-N"
"2092","Q06187","BTK","CRBN","","RNC-10","CN(CCCC(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1)CCOCCNC(=O)CNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","885.983","885.392207592","2.39","65","8","15","4","18","236.31","C46H51N11O8","InChI=1S/C46H51N11O8/c1-54(22-24-64-23-19-48-38(59)26-49-30-13-16-34-35(25-30)46(63)56(45(34)62)36-17-18-37(58)52-44(36)61)20-6-10-39(60)55-21-5-7-31(27-55)57-43-40(42(47)50-28-51-43)41(53-57)29-11-14-33(15-12-29)65-32-8-3-2-4-9-32/h2-4,8-9,11-16,25,28,31,36,49H,5-7,10,17-24,26-27H2,1H3,(H,48,59)(H2,47,50,51)(H,52,58,61)/t31-,36?/m1/s1","QATOVRKHUKAPNY-RACIXVTASA-N"
"2093","Q06187","BTK","CRBN","","RC-10","CN(CCOCCNC(=O)CNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](N2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C3=C(N)N=CN=C32)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","937.031","936.403106624","2.88","69","8","16","4","17","260.1","C49H52N12O8","InChI=1S/C49H52N12O8/c1-49(2,58(3)21-23-68-22-19-52-40(63)27-53-32-13-16-36-37(24-32)48(67)60(47(36)66)38-17-18-39(62)56-45(38)64)25-31(26-50)46(65)59-20-7-8-33(28-59)61-44-41(43(51)54-29-55-44)42(57-61)30-11-14-35(15-12-30)69-34-9-5-4-6-10-34/h4-6,9-16,24-25,29,33,38,53H,7-8,17-23,27-28H2,1-3H3,(H,52,63)(H2,51,54,55)(H,56,62,64)/b31-25+/t33-,38?/m1/s1","JMEOLGMALDVIFD-PYZUAGNDSA-N"
"2094","P36888","FLT3","CRBN","","IRC-FLT3","CCCNC1=NC(NC2=CC=C(C#N)C=C2)=NC=C1C#CCCCNC(=O)[C@H](C)N(C)C(=O)/C=C/CN(C)CCCNC(=O)CCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","1500","Target Engagement IC50 was assessed by NanoBRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","901.042","900.439492132","3.6","66","5","14","6","22","250.96","C47H56N12O7","InChI=1S/C47H56N12O7/c1-5-23-51-42-33(30-53-47(56-42)54-34-18-16-32(29-48)17-19-34)12-7-6-8-24-52-43(63)31(2)58(4)40(62)15-10-27-57(3)28-11-25-50-38(60)22-26-49-36-14-9-13-35-41(36)46(66)59(45(35)65)37-20-21-39(61)55-44(37)64/h9-10,13-19,30-31,37,49H,5-6,8,11,20-28H2,1-4H3,(H,50,60)(H,52,63)(H,55,61,64)(H2,51,53,54,56)/b15-10+/t31-,37?/m0/s1","IKXCXUREHRCQPF-PPSYJUFYSA-N"
"2095","P36888","FLT3","CRBN","","RNC-FLT3","CCCNC1=NC(NC2=CC=C(C#N)C=C2)=NC=C1C#CCCCNC(=O)[C@H](C)N(C)C(=O)CCCN(C)CCCNC(=O)CCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","10100","Target Engagement IC50 was assessed by NanoBRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","903.058","902.455142196","3.63","66","5","14","6","23","250.96","C47H58N12O7","InChI=1S/C47H58N12O7/c1-5-23-51-42-33(30-53-47(56-42)54-34-18-16-32(29-48)17-19-34)12-7-6-8-24-52-43(63)31(2)58(4)40(62)15-10-27-57(3)28-11-25-50-38(60)22-26-49-36-14-9-13-35-41(36)46(66)59(45(35)65)37-20-21-39(61)55-44(37)64/h9,13-14,16-19,30-31,37,49H,5-6,8,10-11,15,20-28H2,1-4H3,(H,50,60)(H,52,63)(H,55,61,64)(H2,51,53,54,56)/t31-,37?/m0/s1","NKMBYAJGMSVJFN-RKBNTCOGSA-N"
"2096","P36888","FLT3","CRBN","","RC-FLT3","CCCNC1=NC(NC2=CC=C(C#N)C=C2)=NC=C1C#CCCCNC(=O)[C@H](C)N(C)C(=O)/C(C#N)=C/C(C)(C)N(C)CCCNC(=O)CCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","300","Target Engagement IC50 was assessed by NanoBRET assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-17997-6","954.106","953.466041228","4.12","70","5","15","6","22","274.75","C50H59N13O7","InChI=1S/C50H59N13O7/c1-7-23-55-43-34(31-57-49(60-43)58-36-18-16-33(29-51)17-19-36)13-9-8-10-24-56-44(66)32(2)62(6)46(68)35(30-52)28-50(3,4)61(5)27-12-25-54-40(64)22-26-53-38-15-11-14-37-42(38)48(70)63(47(37)69)39-20-21-41(65)59-45(39)67/h11,14-19,28,31-32,39,53H,7-8,10,12,20-27H2,1-6H3,(H,54,64)(H,56,66)(H,59,65,67)(H2,55,57,58,60)/b35-28+/t32-,39?/m0/s1","SVYCMGVSKPMMET-CCTKBRMUSA-N"
"2097","P62942","FKBP12 F36V","VHL","","dTAGV-1","CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC=C1OCC(=O)NCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)C1=CC(OC)=C(OC)C(OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-18377-w","1247.563","1246.62357256","10.09","89","7","16","4","30","242.72","C68H90N6O14S","InChI=1S/C68H90N6O14S/c1-12-49(47-36-57(84-9)61(86-11)58(37-47)85-10)65(79)73-34-20-18-22-51(73)67(81)88-54(31-25-44-26-32-55(82-7)56(35-44)83-8)50-21-16-17-23-53(50)87-40-60(77)69-33-19-14-13-15-24-59(76)72-63(68(4,5)6)66(80)74-39-48(75)38-52(74)64(78)71-42(2)45-27-29-46(30-28-45)62-43(3)70-41-89-62/h16-17,21,23,26-30,32,35-37,41-42,48-49,51-52,54,63,75H,12-15,18-20,22,24-25,31,33-34,38-40H2,1-11H3,(H,69,77)(H,71,78)(H,72,76)/t42-,48+,49-,51-,52-,54+,63+/m0/s1","ANLKEOUWAHUESE-HKVQNHBKSA-N"
"2098","P62942","FKBP12 F36V","VHL","","dTAG-63","CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC=C1OCC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)C1=CC(OC)=C(OC)C(OC)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-020-18377-w","1309.587","1308.62396648","8.14","93","7","19","4","34","270.41","C69H92N6O17S","InChI=1S/C69H92N6O17S/c1-12-50(48-36-58(85-9)62(87-11)59(37-48)86-10)66(80)74-29-16-15-18-52(74)68(82)92-55(26-20-45-21-27-56(83-7)57(35-45)84-8)51-17-13-14-19-54(51)91-41-60(77)70-28-30-88-31-32-89-33-34-90-40-61(78)73-64(69(4,5)6)67(81)75-39-49(76)38-53(75)65(79)72-43(2)46-22-24-47(25-23-46)63-44(3)71-42-93-63/h13-14,17,19,21-25,27,35-37,42-43,49-50,52-53,55,64,76H,12,15-16,18,20,26,28-34,38-41H2,1-11H3,(H,70,77)(H,72,79)(H,73,78)/t43-,49+,50-,52-,53-,55+,64+/m0/s1","QTSHFYXEXAHVCR-DBYQZFFGSA-N"
"2099","P09874","PARP1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCNC(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)C=CC=C3C2=O)C(=O)N1","","","","","","71.3","Inhibition of PARP1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1080/14756366.2020.1804382","680.737","680.275861124","3.21","50","6","7","4","13","170.43","C37H37FN6O6","InChI=1S/C37H37FN6O6/c38-28-15-14-22(20-30-23-9-5-6-10-24(23)35(48)43-42-30)19-26(28)34(47)39-18-7-3-1-2-4-13-32(45)40-29-12-8-11-25-27(29)21-44(37(25)50)31-16-17-33(46)41-36(31)49/h5-6,8-12,14-15,19,31H,1-4,7,13,16-18,20-21H2,(H,39,47)(H,40,45)(H,43,48)(H,41,46,49)","VSGNMJOBOUYLRY-UHFFFAOYSA-N"
"2100","P09874","PARP1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCCCCNC(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)C=CC=C3C2=O)C(=O)N1","5400","","Degradation of PARP1 in SW620 cells after 24 h treatment","","","54.7","Inhibition of PARP1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2900","Inhibit proliferation of SW620 cells","","","","","","","","","","","","","","","10.1080/14756366.2020.1804382","722.818","722.322811316","4.83","53","6","7","4","16","170.43","C40H43FN6O6","InChI=1S/C40H43FN6O6/c41-31-18-17-25(23-33-26-12-8-9-13-27(26)38(51)46-45-33)22-29(31)37(50)42-21-10-6-4-2-1-3-5-7-16-35(48)43-32-15-11-14-28-30(32)24-47(40(28)53)34-19-20-36(49)44-39(34)52/h8-9,11-15,17-18,22,34H,1-7,10,16,19-21,23-24H2,(H,42,50)(H,43,48)(H,46,51)(H,44,49,52)","QFFHUSYJWPTYGI-UHFFFAOYSA-N"
"2101","P09874","PARP1","CRBN","","","O=C1CCC(N2CC3=C(NC(=O)CCCCCCCCCCCNC(=O)C4=CC(CC5=N[NH]C(=O)C6=CC=CC=C56)=CC=C4F)C=CC=C3C2=O)C(=O)N1","6200","","Degradation of PARP1 in SW620 cells after 24 h treatment","","","20.7","Inhibition of PARP1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1080/14756366.2020.1804382","736.845","736.33846138","5.38","54","6","7","4","17","170.43","C41H45FN6O6","InChI=1S/C41H45FN6O6/c42-32-19-18-26(24-34-27-13-9-10-14-28(27)39(52)47-46-34)23-30(32)38(51)43-22-11-7-5-3-1-2-4-6-8-17-36(49)44-33-16-12-15-29-31(33)25-48(41(29)54)35-20-21-37(50)45-40(35)53/h9-10,12-16,18-19,23,35H,1-8,11,17,20-22,24-25H2,(H,43,51)(H,44,49)(H,47,52)(H,45,50,53)","ILGXZNUUIJTUAT-UHFFFAOYSA-N"
"2102","P10275","AR","VHL","","MTX-23","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)COC3=C(F)C(F)=CC=C3C3=CSC(N4CCOCC4)=N3)C(C)(C)C)C=C2)SC=N1","2000","","Degradation of AR in 22Rv1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/1535-7163.MCT-20-0417","882.069","881.341595476","5.35","61","6","12","4","16","175.32","C43H53F2N7O7S2","InChI=1S/C43H53F2N7O7S2/c1-25(27-9-11-28(12-10-27)38-26(2)47-24-61-38)48-40(56)33-20-29(53)21-52(33)41(57)39(43(3,4)5)50-34(54)8-6-7-15-46-35(55)22-59-37-30(13-14-31(44)36(37)45)32-23-60-42(49-32)51-16-18-58-19-17-51/h9-14,23-25,29,33,39,53H,6-8,15-22H2,1-5H3,(H,46,55)(H,48,56)(H,50,54)/t25-,29+,33-,39+/m0/s1","JOZGICGAZBMCJF-JMSDHYLISA-N"
"2102","P10275","AR-V7","VHL","","MTX-23","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCNC(=O)COC3=C(F)C(F)=CC=C3C3=CSC(N4CCOCC4)=N3)C(C)(C)C)C=C2)SC=N1","370","","Degradation of AR-V7 in 22Rv1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/1535-7163.MCT-20-0417","882.069","881.341595476","5.35","61","6","12","4","16","175.32","C43H53F2N7O7S2","InChI=1S/C43H53F2N7O7S2/c1-25(27-9-11-28(12-10-27)38-26(2)47-24-61-38)48-40(56)33-20-29(53)21-52(33)41(57)39(43(3,4)5)50-34(54)8-6-7-15-46-35(55)22-59-37-30(13-14-31(44)36(37)45)32-23-60-42(49-32)51-16-18-58-19-17-51/h9-14,23-25,29,33,39,53H,6-8,15-22H2,1-5H3,(H,46,55)(H,48,56)(H,50,54)/t25-,29+,33-,39+/m0/s1","JOZGICGAZBMCJF-JMSDHYLISA-N"
"2103","Q5S007","LRRK2","CRBN","","","N#CC1=CC=CC(C2=C[NH]C3=NC=NC(N4CCOC(CNC(=O)CCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)=C23)=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","703.716","703.250294396","1.32","52","7","11","4","10","219.58","C36H33N9O7","InChI=1S/C36H33N9O7/c37-15-20-4-1-5-21(14-20)24-17-39-32-31(24)33(41-19-40-32)44-12-13-52-22(18-44)16-38-27(46)8-3-9-28(47)42-25-7-2-6-23-30(25)36(51)45(35(23)50)26-10-11-29(48)43-34(26)49/h1-2,4-7,14,17,19,22,26H,3,8-13,16,18H2,(H,38,46)(H,42,47)(H,39,40,41)(H,43,48,49)","UDYJPOTUXDFZCN-UHFFFAOYSA-N"
"2104","Q5S007","LRRK2","CRBN","","","N#CC1=CC=CC(C2=C[NH]C3=NC=NC(N4CCOC(CC(=O)NCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)=C23)=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","675.706","675.255379776","2.2","50","7","11","4","10","202.51","C35H33N9O6","InChI=1S/C35H33N9O6/c36-16-20-4-1-5-21(14-20)24-17-39-31-30(24)32(41-19-40-31)43-12-13-50-22(18-43)15-28(46)38-11-3-10-37-25-7-2-6-23-29(25)35(49)44(34(23)48)26-8-9-27(45)42-33(26)47/h1-2,4-7,14,17,19,22,26,37H,3,8-13,15,18H2,(H,38,46)(H,39,40,41)(H,42,45,47)","NVQXUHMTYDPLRQ-UHFFFAOYSA-N"
"2105","Q5S007","LRRK2","CRBN","","","N#CC1=CC=CC(C2=C[NH]C3=NC=NC(N4CCOC(C(=O)NCC5CCN(CC(=O)NC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C4)=C23)=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","758.796","758.292493556","1.91","56","8","12","4","9","222.82","C39H38N10O7","InChI=1S/C39H38N10O7/c40-16-23-3-1-4-24(15-23)26-18-41-34-33(26)35(44-21-43-34)48-13-14-56-29(19-48)37(53)42-17-22-9-11-47(12-10-22)20-31(51)45-27-6-2-5-25-32(27)39(55)49(38(25)54)28-7-8-30(50)46-36(28)52/h1-6,15,18,21-22,28-29H,7-14,17,19-20H2,(H,42,53)(H,45,51)(H,41,43,44)(H,46,50,52)","SDBHLHNOMSXRIY-UHFFFAOYSA-N"
"2106","Q5S007","LRRK2","CRBN","","","N#CC1=CC=CC(C2=C[NH]C3=NC=NC(N4CCN(C(=O)CCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C23)=C1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","673.69","673.239729712","1.59","50","7","10","3","8","201.56","C35H31N9O6","InChI=1S/C35H31N9O6/c36-17-20-4-1-5-21(16-20)23-18-37-31-30(23)32(39-19-38-31)43-14-12-42(13-15-43)28(47)9-3-8-26(45)40-24-7-2-6-22-29(24)35(50)44(34(22)49)25-10-11-27(46)41-33(25)48/h1-2,4-7,16,18-19,25H,3,8-15H2,(H,40,45)(H,37,38,39)(H,41,46,48)","ABQYIRMSMUIEPF-UHFFFAOYSA-N"
"2107","Q5S007","LRRK2","CRBN","","","CCNC1=NC(NC2=CC(F)=C(C(=O)N3CCOC(CNC(=O)CCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)C=C2OC)=NC=C1C(F)(F)F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","841.776","841.280686708","2.04","60","6","13","5","14","230.36","C38H39F4N9O9","InChI=1S/C38H39F4N9O9/c1-3-43-32-22(38(40,41)42)17-45-37(49-32)47-25-15-23(39)21(14-27(25)59-2)34(56)50-12-13-60-19(18-50)16-44-28(52)8-5-9-29(53)46-24-7-4-6-20-31(24)36(58)51(35(20)57)26-10-11-30(54)48-33(26)55/h4,6-7,14-15,17,19,26H,3,5,8-13,16,18H2,1-2H3,(H,44,52)(H,46,53)(H,48,54,55)(H2,43,45,47,49)","FMKJLSALAKADSF-UHFFFAOYSA-N"
"2108","Q5S007","LRRK2","CRBN","","","CCNC1=NC(NC2=CC(F)=C(C(=O)NCC3CCN(C(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2OC)=NC=C1C(F)(F)F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","769.713","769.25955734","3.38","55","6","11","5","10","204.06","C35H35F4N9O7","InChI=1S/C35H35F4N9O7/c1-3-40-28-20(35(37,38)39)16-42-33(46-28)43-23-14-21(36)19(13-25(23)55-2)29(50)41-15-17-9-11-47(12-10-17)34(54)44-22-6-4-5-18-27(22)32(53)48(31(18)52)24-7-8-26(49)45-30(24)51/h4-6,13-14,16-17,24H,3,7-12,15H2,1-2H3,(H,41,50)(H,44,54)(H,45,49,51)(H2,40,42,43,46)","SNOZHFUVGZIHHA-UHFFFAOYSA-N"
"2109","Q5S007","LRRK2","CRBN","","","CCNC1=NC(NC2=CC(F)=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2OC)=NC=C1C(F)(F)F","","N.D.","","","","14.69","Inhibition of LRRK2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cmdc.202000872","700.65","700.238093624","4.14","50","5","11","5","13","183.75","C32H32F4N8O6","InChI=1S/C32H32F4N8O6/c1-3-37-26-18(32(34,35)36)15-40-31(43-26)41-21-14-19(33)17(13-23(21)50-2)27(46)39-12-5-4-11-38-20-8-6-7-16-25(20)30(49)44(29(16)48)22-9-10-24(45)42-28(22)47/h6-8,13-15,22,38H,3-5,9-12H2,1-2H3,(H,39,46)(H,42,45,47)(H2,37,40,41,43)","NHYGUXAZZSSUPD-UHFFFAOYSA-N"
"2110","Q13547","HDAC1","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCCCCC(=O)NC1=CC=C(NC(=O)CCCCCCC(=O)NO)C=C1","","","","","","30","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","682.863","682.405398068","2.62","49","2","8","8","23","211.98","C36H54N6O7","InChI=1S/C36H54N6O7/c1-25(2)23-30(41-36(48)34(46)29(37)24-26-13-7-5-8-14-26)35(47)38-22-12-6-11-16-32(44)40-28-20-18-27(19-21-28)39-31(43)15-9-3-4-10-17-33(45)42-49/h5,7-8,13-14,18-21,25,29-30,34,46,49H,3-4,6,9-12,15-17,22-24,37H2,1-2H3,(H,38,47)(H,39,43)(H,40,44)(H,41,48)(H,42,45)/t29-,30+,34+/m1/s1","UWGZLQOSUQIMKV-CRBXJKDESA-N"
"2110","Q9UBN7","HDAC6","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCCCCC(=O)NC1=CC=C(NC(=O)CCCCCCC(=O)NO)C=C1","","","","","","11.5","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","682.863","682.405398068","2.62","49","2","8","8","23","211.98","C36H54N6O7","InChI=1S/C36H54N6O7/c1-25(2)23-30(41-36(48)34(46)29(37)24-26-13-7-5-8-14-26)35(47)38-22-12-6-11-16-32(44)40-28-20-18-27(19-21-28)39-31(43)15-9-3-4-10-17-33(45)42-49/h5,7-8,13-14,18-21,25,29-30,34,46,49H,3-4,6,9-12,15-17,22-24,37H2,1-2H3,(H,38,47)(H,39,43)(H,40,44)(H,41,48)(H,42,45)/t29-,30+,34+/m1/s1","UWGZLQOSUQIMKV-CRBXJKDESA-N"
"2110","Q9BY41","HDAC8","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCCCCC(=O)NC1=CC=C(NC(=O)CCCCCCC(=O)NO)C=C1","","","","","","694","Inhibition of HDAC8","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","682.863","682.405398068","2.62","49","2","8","8","23","211.98","C36H54N6O7","InChI=1S/C36H54N6O7/c1-25(2)23-30(41-36(48)34(46)29(37)24-26-13-7-5-8-14-26)35(47)38-22-12-6-11-16-32(44)40-28-20-18-27(19-21-28)39-31(43)15-9-3-4-10-17-33(45)42-49/h5,7-8,13-14,18-21,25,29-30,34,46,49H,3-4,6,9-12,15-17,22-24,37H2,1-2H3,(H,38,47)(H,39,43)(H,40,44)(H,41,48)(H,42,45)/t29-,30+,34+/m1/s1","UWGZLQOSUQIMKV-CRBXJKDESA-N"
"2111","Q13547","HDAC1","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCCNC(=O)C1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","601.701","601.311163336","0.54","43","2","9","7","19","201.34","C30H43N5O8","InChI=1S/C30H43N5O8/c1-20(2)17-25(34-30(40)26(36)24(31)18-21-7-4-3-5-8-21)29(39)33-12-14-43-16-15-42-13-11-32-27(37)22-9-6-10-23(19-22)28(38)35-41/h3-10,19-20,24-26,36,41H,11-18,31H2,1-2H3,(H,32,37)(H,33,39)(H,34,40)(H,35,38)/t24-,25+,26+/m1/s1","IYGDOPARKDXLDH-ZNZIZOMTSA-N"
"2111","Q9UBN7","HDAC6","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCCNC(=O)C1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","601.701","601.311163336","0.54","43","2","9","7","19","201.34","C30H43N5O8","InChI=1S/C30H43N5O8/c1-20(2)17-25(34-30(40)26(36)24(31)18-21-7-4-3-5-8-21)29(39)33-12-14-43-16-15-42-13-11-32-27(37)22-9-6-10-23(19-22)28(38)35-41/h3-10,19-20,24-26,36,41H,11-18,31H2,1-2H3,(H,32,37)(H,33,39)(H,34,40)(H,35,38)/t24-,25+,26+/m1/s1","IYGDOPARKDXLDH-ZNZIZOMTSA-N"
"2111","Q9BY41","HDAC8","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCCNC(=O)C1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","601.701","601.311163336","0.54","43","2","9","7","19","201.34","C30H43N5O8","InChI=1S/C30H43N5O8/c1-20(2)17-25(34-30(40)26(36)24(31)18-21-7-4-3-5-8-21)29(39)33-12-14-43-16-15-42-13-11-32-27(37)22-9-6-10-23(19-22)28(38)35-41/h3-10,19-20,24-26,36,41H,11-18,31H2,1-2H3,(H,32,37)(H,33,39)(H,34,40)(H,35,38)/t24-,25+,26+/m1/s1","IYGDOPARKDXLDH-ZNZIZOMTSA-N"
"2112","Q13547","HDAC1","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCC(=O)NC1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","587.674","587.295513272","0.47","42","2","9","7","18","201.34","C29H41N5O8","InChI=1S/C29H41N5O8/c1-19(2)15-24(33-29(39)26(36)23(30)16-20-7-4-3-5-8-20)28(38)31-11-12-41-13-14-42-18-25(35)32-22-10-6-9-21(17-22)27(37)34-40/h3-10,17,19,23-24,26,36,40H,11-16,18,30H2,1-2H3,(H,31,38)(H,32,35)(H,33,39)(H,34,37)/t23-,24+,26+/m1/s1","LDXDPRNADIWJKK-USZFVNFHSA-N"
"2112","Q9UBN7","HDAC6","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCC(=O)NC1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","587.674","587.295513272","0.47","42","2","9","7","18","201.34","C29H41N5O8","InChI=1S/C29H41N5O8/c1-19(2)15-24(33-29(39)26(36)23(30)16-20-7-4-3-5-8-20)28(38)31-11-12-41-13-14-42-18-25(35)32-22-10-6-9-21(17-22)27(37)34-40/h3-10,17,19,23-24,26,36,40H,11-16,18,30H2,1-2H3,(H,31,38)(H,32,35)(H,33,39)(H,34,37)/t23-,24+,26+/m1/s1","LDXDPRNADIWJKK-USZFVNFHSA-N"
"2112","Q9BY41","HDAC8","cIAP1","","","CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)NCCOCCOCC(=O)NC1=CC=CC(C(=O)NO)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules25214991","587.674","587.295513272","0.47","42","2","9","7","18","201.34","C29H41N5O8","InChI=1S/C29H41N5O8/c1-19(2)15-24(33-29(39)26(36)23(30)16-20-7-4-3-5-8-20)28(38)31-11-12-41-13-14-42-18-25(35)32-22-10-6-9-21(17-22)27(37)34-40/h3-10,17,19,23-24,26,36,40H,11-16,18,30H2,1-2H3,(H,31,38)(H,32,35)(H,33,39)(H,34,37)/t23-,24+,26+/m1/s1","LDXDPRNADIWJKK-USZFVNFHSA-N"
"2113","Q05397","FAK","CRBN","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2OC)=NC=C1C(F)(F)F","","","",">85/>85","% FAK degradation in PA-TU-8988T cells after 4 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00290","913.955","913.37344422","5.53","66","7","13","5","18","203.64","C46H50F3N9O8","InChI=1S/C46H50F3N9O8/c1-50-42(61)29-10-5-6-12-32(29)53-34-25-38(52-26-31(34)46(47,48)49)54-33-15-14-28(24-37(33)65-2)57-22-20-56(21-23-57)19-8-4-3-7-18-51-40(60)27-66-36-13-9-11-30-41(36)45(64)58(44(30)63)35-16-17-39(59)55-43(35)62/h5-6,9-15,24-26,35H,3-4,7-8,16-23,27H2,1-2H3,(H,50,61)(H,51,60)(H2,52,53,54)(H,55,59,62)","PNWQOAJYGQFEQU-UHFFFAOYSA-N"
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"2126","P03372","ER","CRBN","","","C[C@@H]1CC2=C([NH]C3=CC=CC=C23)[C@@H](C2=CN=C(N3CCC(CN4CCOC5(CC4)CCN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)CC6=C4)CC5)CC3)N=C2)N1CC(C)(C)F","0.4","","Degradation of ERalpha in MCF-7 cells","","","5.3","IC50 of ERalpha was assessed by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00589","846.065","845.47522962","5.0","62","10","10","2","8","130.24","C48H60FN9O4","InChI=1S/C48H60FN9O4/c1-31-24-38-37-6-4-5-7-39(37)52-42(38)43(58(31)30-47(2,3)49)34-26-50-46(51-27-34)56-17-12-32(13-18-56)28-54-19-14-48(62-23-22-54)15-20-55(21-16-48)35-8-9-36-33(25-35)29-57(45(36)61)40-10-11-41(59)53-44(40)60/h4-9,25-27,31-32,40,43,52H,10-24,28-30H2,1-3H3,(H,53,59,60)/t31-,40?,43-/m1/s1","ZDKSTADPBFKRTK-VZGKAOHESA-N"
"2127","P03372","ER","CRBN","","","C[C@@H]1CC2=C([NH]C3=CC=CC=C23)[C@@H](C2=CN=C(N3CCC(CCN4CCOC5(CC4)CCN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)CC6=C4)CC5)CC3)N=C2)N1CC(C)(C)F","0.5","","Degradation of ERalpha in MCF-7 cells","","","2","IC50 of ERalpha was assessed by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00589","860.092","859.490879684","5.35","63","10","10","2","9","130.24","C49H62FN9O4","InChI=1S/C49H62FN9O4/c1-32-26-39-38-6-4-5-7-40(38)53-43(39)44(59(32)31-48(2,3)50)35-28-51-47(52-29-35)57-19-13-33(14-20-57)12-18-55-21-15-49(63-25-24-55)16-22-56(23-17-49)36-8-9-37-34(27-36)30-58(46(37)62)41-10-11-42(60)54-45(41)61/h4-9,27-29,32-33,41,44,53H,10-26,30-31H2,1-3H3,(H,54,60,61)/t32-,41?,44-/m1/s1","LRCKXZMRGJWXQI-GNDFOHGCSA-N"
"2128","P03372","ER","CRBN","","","C[C@@H]1CC2=C([NH]C3=CC=CC=C23)[C@@H](C2=CN=C(N3CCC4(CC3)CC(CN3CC5(CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)CC7=C6)CC5)C3)C4)N=C2)N1CC(C)(C)F","0.4","","Degradation of ERalpha in MCF-7 cells","","","1.9","IC50 of ERalpha was assessed by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00589","842.077","841.480315","5.62","62","11","9","2","8","121.01","C49H60FN9O3","InChI=1S/C49H60FN9O3/c1-31-20-38-37-6-4-5-7-39(37)53-42(38)43(59(31)28-47(2,3)50)34-24-51-46(52-25-34)57-18-12-48(13-19-57)22-32(23-48)26-55-29-49(30-55)14-16-56(17-15-49)35-8-9-36-33(21-35)27-58(45(36)62)40-10-11-41(60)54-44(40)61/h4-9,21,24-25,31-32,40,43,53H,10-20,22-23,26-30H2,1-3H3,(H,54,60,61)/t31-,40?,43-/m1/s1","QFRXPTNFPOHCTQ-VZGKAOHESA-N"
"2129","P03372","ER","CRBN","","","COC1=CC(N2CCN(CC3CCN(C4=NC=C([C@@H]5C6=C(C[C@@H](C)N5CC(C)(C)F)C5=CC=CC=C5[NH]6)C=N4)CC3)CC2)=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2","0.7","","Degradation of ERalpha in MCF-7 cells","","","3.2","IC50 of ERalpha was assessed by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00589","791.973","791.428279428","4.39","58","9","10","2","9","130.24","C44H54FN9O4","InChI=1S/C44H54FN9O4/c1-27-19-33-32-7-5-6-8-34(32)48-39(33)40(54(27)26-44(2,3)45)30-22-46-43(47-23-30)52-13-11-28(12-14-52)24-50-15-17-51(18-16-50)31-20-29-25-53(35-9-10-37(55)49-41(35)56)42(57)38(29)36(21-31)58-4/h5-8,20-23,27-28,35,40,48H,9-19,24-26H2,1-4H3,(H,49,55,56)/t27-,35?,40-/m1/s1","HWCUOPSCISMUJK-IXGPZBLMSA-N"
"2130","P03372","ER","CRBN","","","C[C@@H]1CC2=C([NH]C3=CC=CC=C23)[C@@H](C2=CN=C(OC3CCC4(CC3)CCN(CC3CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)CC6=C5)CC3)CC4)N=C2)N1CC(C)(C)F","0.4","","Degradation of ERalpha in MCF-7 cells","","","2.2","IC50 of ERalpha was assessed by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00589","845.077","844.479980652","6.36","62","10","9","2","9","127.0","C49H61FN8O4","InChI=1S/C49H61FN8O4/c1-31-24-39-38-6-4-5-7-40(38)53-43(39)44(58(31)30-48(2,3)50)34-26-51-47(52-27-34)62-36-12-16-49(17-13-36)18-22-55(23-19-49)28-32-14-20-56(21-15-32)35-8-9-37-33(25-35)29-57(46(37)61)41-10-11-42(59)54-45(41)60/h4-9,25-27,31-32,36,41,44,53H,10-24,28-30H2,1-3H3,(H,54,59,60)/t31-,41?,44-/m1/s1","YVQDCQVRYNZDBP-MPNICMQISA-N"
"2131","P51531","SMARCA2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(OCCN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","41","99","Degradation of SMARCA2 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","950.151","949.43204448","5.44","68","8","14","5","17","208.6","C50H60FN9O7S","InChI=1S/C50H60FN9O7S/c1-31-43(68-30-54-31)33-11-12-34(28-53-46(63)40-26-35(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)16-17-50)42(25-33)67-23-15-32-9-13-36(14-10-32)66-24-22-58-18-20-59(21-19-58)39-27-38(56-57-45(39)52)37-7-5-6-8-41(37)62/h5-14,25,27,30,35,40,44,61-62H,15-24,26,28-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t35-,40+,44-/m1/s1","CVBRBVVZZZJXQO-HOPMZIQWSA-N"
"2131","P51532","SMARCA4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(OCCN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","26","99","Degradation of SMARCA4 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","950.151","949.43204448","5.44","68","8","14","5","17","208.6","C50H60FN9O7S","InChI=1S/C50H60FN9O7S/c1-31-43(68-30-54-31)33-11-12-34(28-53-46(63)40-26-35(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)16-17-50)42(25-33)67-23-15-32-9-13-36(14-10-32)66-24-22-58-18-20-59(21-19-58)39-27-38(56-57-45(39)52)37-7-5-6-8-41(37)62/h5-14,25,27,30,35,40,44,61-62H,15-24,26,28-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t35-,40+,44-/m1/s1","CVBRBVVZZZJXQO-HOPMZIQWSA-N"
"2132","P51531","SMARCA2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCOC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","26","99","Degradation of SMARCA2 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","950.151","949.43204448","5.34","68","8","14","5","17","208.6","C50H60FN9O7S","InChI=1S/C50H60FN9O7S/c1-31-43(68-30-54-31)33-12-13-34(27-53-46(63)40-25-35(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)16-17-50)42(24-33)67-23-7-22-66-36-14-10-32(11-15-36)28-58-18-20-59(21-19-58)39-26-38(56-57-45(39)52)37-8-5-6-9-41(37)62/h5-6,8-15,24,26,30,35,40,44,61-62H,7,16-23,25,27-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t35-,40+,44-/m1/s1","LPYXXDVKMQAWIP-HOPMZIQWSA-N"
"2132","P51532","SMARCA4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCOC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","16","100","Degradation of SMARCA4 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","950.151","949.43204448","5.34","68","8","14","5","17","208.6","C50H60FN9O7S","InChI=1S/C50H60FN9O7S/c1-31-43(68-30-54-31)33-12-13-34(27-53-46(63)40-25-35(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)16-17-50)42(24-33)67-23-7-22-66-36-14-10-32(11-15-36)28-58-18-20-59(21-19-58)39-26-38(56-57-45(39)52)37-8-5-6-9-41(37)62/h5-6,8-15,24,26,30,35,40,44,61-62H,7,16-23,25,27-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t35-,40+,44-/m1/s1","LPYXXDVKMQAWIP-HOPMZIQWSA-N"
"2133","P51531","SMARCA2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","58","90","Degradation of SMARCA2 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","934.152","933.43712986","5.63","67","8","13","5","16","199.37","C50H60FN9O6S","InChI=1S/C50H60FN9O6S/c1-31-43(67-30-54-31)34-15-16-35(27-53-46(63)40-25-36(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)17-18-50)42(24-34)66-23-7-8-32-11-13-33(14-12-32)28-58-19-21-59(22-20-58)39-26-38(56-57-45(39)52)37-9-5-6-10-41(37)62/h5-6,9-16,24,26,30,36,40,44,61-62H,7-8,17-23,25,27-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t36-,40+,44-/m1/s1","KKFAKGWHXAANIL-OTIWGHMISA-N"
"2133","P51532","SMARCA4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C=C3)=C2)SC=N1","25","92","Degradation of SMARCA4 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","934.152","933.43712986","5.63","67","8","13","5","16","199.37","C50H60FN9O6S","InChI=1S/C50H60FN9O6S/c1-31-43(67-30-54-31)34-15-16-35(27-53-46(63)40-25-36(61)29-60(40)47(64)44(49(2,3)4)55-48(65)50(51)17-18-50)42(24-34)66-23-7-8-32-11-13-33(14-12-32)28-58-19-21-59(22-20-58)39-26-38(56-57-45(39)52)37-9-5-6-10-41(37)62/h5-6,9-16,24,26,30,36,40,44,61-62H,7-8,17-23,25,27-29H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t36-,40+,44-/m1/s1","KKFAKGWHXAANIL-OTIWGHMISA-N"
"2134","P51531","SMARCA2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C(F)=C3)=C2)SC=N1","55","95","Degradation of SMARCA2 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","938.115","937.412057984","5.37","67","8","13","5","15","199.37","C49H57F2N9O6S","InChI=1S/C49H57F2N9O6S/c1-29-42(67-28-54-29)31-11-12-32(25-53-45(63)39-23-34(61)27-60(39)46(64)43(48(2,3)4)55-47(65)49(51)14-15-49)41(22-31)66-20-13-30-9-10-33(36(50)21-30)26-58-16-18-59(19-17-58)38-24-37(56-57-44(38)52)35-7-5-6-8-40(35)62/h5-12,21-22,24,28,34,39,43,61-62H,13-20,23,25-27H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t34-,39+,43-/m1/s1","TWFCHBNLUUPMHG-SQKKEFIPSA-N"
"2134","P51532","SMARCA4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCC3=CC=C(CN4CCN(C5=CC(C6=CC=CC=C6O)=NN=C5N)CC4)C(F)=C3)=C2)SC=N1","33","95","Degradation of SMARCA4 in A549 cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.0c00347","938.115","937.412057984","5.37","67","8","13","5","15","199.37","C49H57F2N9O6S","InChI=1S/C49H57F2N9O6S/c1-29-42(67-28-54-29)31-11-12-32(25-53-45(63)39-23-34(61)27-60(39)46(64)43(48(2,3)4)55-47(65)49(51)14-15-49)41(22-31)66-20-13-30-9-10-33(36(50)21-30)26-58-16-18-59(19-17-58)38-24-37(56-57-44(38)52)35-7-5-6-8-40(35)62/h5-12,21-22,24,28,34,39,43,61-62H,13-20,23,25-27H2,1-4H3,(H2,52,57)(H,53,63)(H,55,65)/t34-,39+,43-/m1/s1","TWFCHBNLUUPMHG-SQKKEFIPSA-N"
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"2202","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","77.3/96.9","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","107/107","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","794.913","794.354031192","5.36","59","9","10","3","7","179.02","C45H46N8O6","InChI=1S/C45H46N8O6/c1-4-26-21-30-31(45(2,3)41-39(40(30)56)28-9-8-25(23-46)20-33(28)48-41)22-35(26)51-14-12-27(13-15-51)50-16-18-52(19-17-50)37(55)24-47-32-7-5-6-29-38(32)44(59)53(43(29)58)34-10-11-36(54)49-42(34)57/h5-9,20-22,27,34,47-48H,4,10-19,24H2,1-3H3,(H,49,54,57)","VYAVALFZAUHAMN-UHFFFAOYSA-N"
"2203","Q9UM73","ALK","VHL","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.5","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","1022.33","1021.52480199","7.56","74","9","11","4","14","195.07","C58H71N9O6S","InChI=1S/C58H71N9O6S/c1-8-38-28-43-44(58(6,7)53-50(51(43)71)42-18-15-37(31-59)27-45(42)62-53)30-46(38)65-21-19-40(20-22-65)64-23-25-66(26-24-64)49(70)12-10-9-11-48(69)63-54(57(3,4)5)56(73)67-33-41(68)29-47(67)55(72)60-32-36-13-16-39(17-14-36)52-35(2)61-34-74-52/h13-18,27-28,30,34,40-41,47,54,62,68H,8-12,19-26,29,32-33H2,1-7H3,(H,60,72)(H,63,69)/t41-,47+,54-/m1/s1","JOQZWUYDRUKKKX-NIAYCYJCSA-N"
"2204","Q9UM73","ALK","VHL","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","1078.438","1077.58740225","9.73","78","9","11","4","18","195.07","C62H79N9O6S","InChI=1S/C62H79N9O6S/c1-8-42-32-47-48(62(6,7)57-54(55(47)75)46-22-19-41(35-63)31-49(46)66-57)34-50(42)69-25-23-44(24-26-69)68-27-29-70(30-28-68)53(74)16-14-12-10-9-11-13-15-52(73)67-58(61(3,4)5)60(77)71-37-45(72)33-51(71)59(76)64-36-40-17-20-43(21-18-40)56-39(2)65-38-78-56/h17-22,31-32,34,38,44-45,51,58,66,72H,8-16,23-30,33,36-37H2,1-7H3,(H,64,76)(H,67,73)/t45-,51+,58-/m1/s1","UYNGRWPFAGHOKG-KRBGMXPFSA-N"
"2205","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","30.8","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","813.912","813.348611464","4.38","60","8","11","3","13","194.24","C45H47N7O8","InChI=1S/C45H47N7O8/c1-4-27-23-30-31(45(2,3)41-39(40(30)55)28-9-8-26(25-46)22-33(28)48-41)24-35(27)50-14-16-51(17-15-50)37(54)12-18-59-20-21-60-19-13-47-32-7-5-6-29-38(32)44(58)52(43(29)57)34-10-11-36(53)49-42(34)56/h5-9,22-24,34,47-48H,4,10-21H2,1-3H3,(H,49,53,56)","HNBUMPYCGIBULR-UHFFFAOYSA-N"
"2206","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","902.018","901.40104096","4.08","66","8","13","3","19","212.7","C49H55N7O10","InChI=1S/C49H55N7O10/c1-4-31-27-34-35(49(2,3)45-43(44(34)59)32-9-8-30(29-50)26-37(32)52-45)28-39(31)54-14-16-55(17-15-54)41(58)12-18-63-20-22-65-24-25-66-23-21-64-19-13-51-36-7-5-6-33-42(36)48(62)56(47(33)61)38-10-11-40(57)53-46(38)60/h5-9,26-28,38,51-52H,4,10-25H2,1-3H3,(H,53,57,60)","KNDFMJRNCZGZIH-UHFFFAOYSA-N"
"2207","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(NC(=O)CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","827.939","827.364261528","4.97","61","8","11","4","14","203.03","C46H49N7O8","InChI=1S/C46H49N7O8/c1-4-27-23-31-32(46(2,3)42-40(41(31)56)29-9-8-26(25-47)22-34(29)50-42)24-36(27)52-16-12-28(13-17-52)49-38(55)14-18-60-20-21-61-19-15-48-33-7-5-6-30-39(33)45(59)53(44(30)58)35-10-11-37(54)51-43(35)57/h5-9,22-24,28,35,48,50H,4,10-21H2,1-3H3,(H,49,55)(H,51,54,57)","QLCIFEXEABTBHV-UHFFFAOYSA-N"
"2208","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(NC(=O)CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","916.045","915.416691024","4.68","67","8","13","4","20","221.49","C50H57N7O10","InChI=1S/C50H57N7O10/c1-4-31-27-35-36(50(2,3)46-44(45(35)60)33-9-8-30(29-51)26-38(33)54-46)28-40(31)56-16-12-32(13-17-56)53-42(59)14-18-64-20-22-66-24-25-67-23-21-65-19-15-52-37-7-5-6-34-43(37)49(63)57(48(34)62)39-10-11-41(58)55-47(39)61/h5-9,26-28,32,39,52,54H,4,10-25H2,1-3H3,(H,53,59)(H,55,58,61)","VLDLPRANROJJRL-UHFFFAOYSA-N"
"2209","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","27.4/116.5","","Degradation of ALK in H3122/Karpas 299 cells after 16/48 h treatment","","","13.63","IC50 was tested by TR-FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","62/42","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","711.779","711.280531904","4.77","53","8","9","3","6","175.78","C40H37N7O6","InChI=1S/C40H37N7O6/c1-4-22-17-25-26(40(2,3)36-34(35(25)50)23-9-8-21(19-41)16-28(23)43-36)18-30(22)45-12-14-46(15-13-45)32(49)20-42-27-7-5-6-24-33(27)39(53)47(38(24)52)29-10-11-31(48)44-37(29)51/h5-9,16-18,29,42-43H,4,10-15,20H2,1-3H3,(H,44,48,51)","UMEMOEKJTJMMJN-UHFFFAOYSA-N"
"2209","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","711.779","711.280531904","4.77","53","8","9","3","6","175.78","C40H37N7O6","InChI=1S/C40H37N7O6/c1-4-22-17-25-26(40(2,3)36-34(35(25)50)23-9-8-21(19-41)16-28(23)43-36)18-30(22)45-12-14-46(15-13-45)32(49)20-42-27-7-5-6-24-33(27)39(53)47(38(24)52)29-10-11-31(48)44-37(29)51/h5-9,16-18,29,42-43H,4,10-15,20H2,1-3H3,(H,44,48,51)","UMEMOEKJTJMMJN-UHFFFAOYSA-N"
"2210","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","739.833","739.311832032","5.03","55","8","9","3","8","175.78","C42H41N7O6","InChI=1S/C42H41N7O6/c1-4-24-20-27-28(42(2,3)38-36(37(27)52)25-11-10-23(22-43)19-30(25)45-38)21-32(24)47-15-17-48(18-16-47)34(51)9-6-14-44-29-8-5-7-26-35(29)41(55)49(40(26)54)31-12-13-33(50)46-39(31)53/h5,7-8,10-11,19-21,31,44-45H,4,6,9,12-18H2,1-3H3,(H,46,50,53)","CTTFKCVPGPPVQB-UHFFFAOYSA-N"
"2210","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","77.4/85.9","% ALK degradation in Karpas 299 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","92/66","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","739.833","739.311832032","5.03","55","8","9","3","8","175.78","C42H41N7O6","InChI=1S/C42H41N7O6/c1-4-24-20-27-28(42(2,3)38-36(37(27)52)25-11-10-23(22-43)19-30(25)45-38)21-32(24)47-15-17-48(18-16-47)34(51)9-6-14-44-29-8-5-7-26-35(29)41(55)49(40(26)54)31-12-13-33(50)46-39(31)53/h5,7-8,10-11,19-21,31,44-45H,4,6,9,12-18H2,1-3H3,(H,46,50,53)","CTTFKCVPGPPVQB-UHFFFAOYSA-N"
"2211","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.1","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","767.887","767.34313216","5.74","57","8","9","3","10","175.78","C44H45N7O6","InChI=1S/C44H45N7O6/c1-4-26-22-29-30(44(2,3)40-38(39(29)54)27-13-12-25(24-45)21-32(27)47-40)23-34(26)49-17-19-50(20-18-49)36(53)11-6-5-7-16-46-31-10-8-9-28-37(31)43(57)51(42(28)56)33-14-15-35(52)48-41(33)55/h8-10,12-13,21-23,33,46-47H,4-7,11,14-20H2,1-3H3,(H,48,52,55)","HPWASJPVHGPZEW-UHFFFAOYSA-N"
"2211","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C(=O)CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","55.1/71.6","% ALK degradation in Karpas 299 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","269/245","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","767.887","767.34313216","5.74","57","8","9","3","10","175.78","C44H45N7O6","InChI=1S/C44H45N7O6/c1-4-26-22-29-30(44(2,3)40-38(39(29)54)27-13-12-25(24-45)21-32(27)47-40)23-34(26)49-17-19-50(20-18-49)36(53)11-6-5-7-16-46-31-10-8-9-28-37(31)43(57)51(42(28)56)33-14-15-35(52)48-41(33)55/h8-10,12-13,21-23,33,46-47H,4-7,11,14-20H2,1-3H3,(H,48,52,55)","HPWASJPVHGPZEW-UHFFFAOYSA-N"
"2212","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(NC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13.5","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","725.806","725.296181968","5.37","54","8","9","4","7","184.57","C41H39N7O6","InChI=1S/C41H39N7O6/c1-4-22-17-26-27(41(2,3)37-35(36(26)51)24-9-8-21(19-42)16-29(24)45-37)18-31(22)47-14-12-23(13-15-47)44-33(50)20-43-28-7-5-6-25-34(28)40(54)48(39(25)53)30-10-11-32(49)46-38(30)52/h5-9,16-18,23,30,43,45H,4,10-15,20H2,1-3H3,(H,44,50)(H,46,49,52)","AZPROZKKEDVIBL-UHFFFAOYSA-N"
"2213","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(NC(=O)CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","753.86","753.327482096","5.63","56","8","9","4","9","184.57","C43H43N7O6","InChI=1S/C43H43N7O6/c1-4-24-20-28-29(43(2,3)39-37(38(28)53)26-11-10-23(22-44)19-31(26)47-39)21-33(24)49-17-14-25(15-18-49)46-34(51)9-6-16-45-30-8-5-7-27-36(30)42(56)50(41(27)55)32-12-13-35(52)48-40(32)54/h5,7-8,10-11,19-21,25,32,45,47H,4,6,9,12-18H2,1-3H3,(H,46,51)(H,48,52,54)","HEOXGAMHUFUJRG-UHFFFAOYSA-N"
"2214","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(NC(=O)CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.8","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","781.914","781.358782224","6.34","58","8","9","4","11","184.57","C45H47N7O6","InChI=1S/C45H47N7O6/c1-4-26-22-30-31(45(2,3)41-39(40(30)55)28-13-12-25(24-46)21-33(28)49-41)23-35(26)51-19-16-27(17-20-51)48-36(53)11-6-5-7-18-47-32-10-8-9-29-38(32)44(58)52(43(29)57)34-14-15-37(54)50-42(34)56/h8-10,12-13,21-23,27,34,47,49H,4-7,11,14-20H2,1-3H3,(H,48,53)(H,50,54,56)","JSPASYUPWLXRNY-UHFFFAOYSA-N"
"2215","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","822.967","822.38533132","5.62","61","9","10","3","9","179.02","C47H50N8O6","InChI=1S/C47H50N8O6/c1-4-28-24-32-33(47(2,3)43-41(42(32)58)30-11-10-27(26-48)23-35(30)50-43)25-37(28)53-17-14-29(15-18-53)52-19-21-54(22-20-52)39(57)9-6-16-49-34-8-5-7-31-40(34)46(61)55(45(31)60)36-12-13-38(56)51-44(36)59/h5,7-8,10-11,23-25,29,36,49-50H,4,6,9,12-22H2,1-3H3,(H,51,56,59)","UTASMCZTAQXUGH-UHFFFAOYSA-N"
"2216","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.4","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","851.021","850.416631448","6.33","63","9","10","3","11","179.02","C49H54N8O6","InChI=1S/C49H54N8O6/c1-4-30-26-34-35(49(2,3)45-43(44(34)60)32-13-12-29(28-50)25-37(32)52-45)27-39(30)55-19-16-31(17-20-55)54-21-23-56(24-22-54)41(59)11-6-5-7-18-51-36-10-8-9-33-42(36)48(63)57(47(33)62)38-14-15-40(58)53-46(38)61/h8-10,12-13,25-27,31,38,51-52H,4-7,11,14-24H2,1-3H3,(H,53,58,61)","IONMHLOLDHCTQS-UHFFFAOYSA-N"
"2217","Q9UM73","ALK","CRBN","","SIAIS091","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","6.1","87.7","Degradation of ALK in SR cells","","","4.7","Inhibition of ALK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","780.93","780.374766636","4.86","58","9","9","3","7","161.95","C45H48N8O5","InChI=1S/C45H48N8O5/c1-4-27-21-31-33(45(2,3)42-40(41(31)56)30-9-8-26(23-46)20-35(30)48-42)22-37(27)51-14-12-28(13-15-51)50-16-18-52(19-17-50)39(55)24-47-34-7-5-6-29-32(34)25-53(44(29)58)36-10-11-38(54)49-43(36)57/h5-9,20-22,28,36,47-48H,4,10-19,24-25H2,1-3H3,(H,49,54,57)","BWJIJVUAQRLZRJ-UHFFFAOYSA-N"
"2217","Q9UM73","ALK G1202R","CRBN","","SIAIS091","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","90.5","Inhibition of ALK G1202R","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","780.93","780.374766636","4.86","58","9","9","3","7","161.95","C45H48N8O5","InChI=1S/C45H48N8O5/c1-4-27-21-31-33(45(2,3)42-40(41(31)56)30-9-8-26(23-46)20-35(30)48-42)22-37(27)51-14-12-28(13-15-51)50-16-18-52(19-17-50)39(55)24-47-34-7-5-6-29-32(34)25-53(44(29)58)36-10-11-38(54)49-43(36)57/h5-9,20-22,28,36,47-48H,4,10-19,24-25H2,1-3H3,(H,49,54,57)","BWJIJVUAQRLZRJ-UHFFFAOYSA-N"
"2218","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.3","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","808.984","808.406066764","5.12","60","9","9","3","9","161.95","C47H52N8O5","InChI=1S/C47H52N8O5/c1-4-29-24-33-35(47(2,3)44-42(43(33)58)32-11-10-28(26-48)23-37(32)50-44)25-39(29)53-17-14-30(15-18-53)52-19-21-54(22-20-52)41(57)9-6-16-49-36-8-5-7-31-34(36)27-55(46(31)60)38-12-13-40(56)51-45(38)59/h5,7-8,10-11,23-25,30,38,49-50H,4,6,9,12-22,27H2,1-3H3,(H,51,56,59)","AXOJVHXFLNRTDA-UHFFFAOYSA-N"
"2219","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.7","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","823.011","822.421716828","5.48","61","9","9","3","10","161.95","C48H54N8O5","InChI=1S/C48H54N8O5/c1-4-30-25-34-36(48(2,3)45-43(44(34)59)33-12-11-29(27-49)24-38(33)51-45)26-40(30)54-18-15-31(16-19-54)53-20-22-55(23-21-53)42(58)10-5-6-17-50-37-9-7-8-32-35(37)28-56(47(32)61)39-13-14-41(57)52-46(39)60/h7-9,11-12,24-26,31,39,50-51H,4-6,10,13-23,28H2,1-3H3,(H,52,57,60)","BSFSYUALUWJJCJ-UHFFFAOYSA-N"
"2220","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCCNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","837.038","836.437366892","5.84","62","9","9","3","11","161.95","C49H56N8O5","InChI=1S/C49H56N8O5/c1-4-31-26-35-37(49(2,3)46-44(45(35)60)34-13-12-30(28-50)25-39(34)52-46)27-41(31)55-19-16-32(17-20-55)54-21-23-56(24-22-54)43(59)11-6-5-7-18-51-38-10-8-9-33-36(38)29-57(48(33)62)40-14-15-42(58)53-47(40)61/h8-10,12-13,25-27,32,40,51-52H,4-7,11,14-24,29H2,1-3H3,(H,53,58,61)","GZLNCTCXXOTSHE-UHFFFAOYSA-N"
"2221","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C(=O)CCCCCCNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","851.065","850.453016956","6.38","63","9","9","3","12","161.95","C50H58N8O5","InChI=1S/C50H58N8O5/c1-4-32-27-36-38(50(2,3)47-45(46(36)61)35-14-13-31(29-51)26-40(35)53-47)28-42(32)56-20-17-33(18-21-56)55-22-24-57(25-23-55)44(60)12-7-5-6-8-19-52-39-11-9-10-34-37(39)30-58(49(34)63)41-15-16-43(59)54-48(41)62/h9-11,13-14,26-28,33,41,52-53H,4-8,12,15-25,30H2,1-3H3,(H,54,59,62)","SBFDGYVTPKRUTK-UHFFFAOYSA-N"
"2222","Q9UM73","ALK","CRBN","","SIAIS001","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","3.9","70.3","Degradation of ALK in SR cells","","","3.3","Inhibition of ALK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","789.981","789.400253112","6.4","59","9","8","2","7","132.85","C48H51N7O4","InChI=1S/C48H51N7O4/c1-4-31-26-36-38(48(2,3)45-43(44(36)57)35-13-12-30(28-49)25-39(35)50-45)27-41(31)54-19-16-33(17-20-54)53-23-21-52(22-24-53)18-7-5-6-9-32-10-8-11-34-37(32)29-55(47(34)59)40-14-15-42(56)51-46(40)58/h8,10-13,25-27,33,40,50H,4-5,7,14-24,29H2,1-3H3,(H,51,56,58)","OGAOHACYLUBWJQ-UHFFFAOYSA-N"
"2222","Q9UM73","ALK G1202R","CRBN","","SIAIS001","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","200","","Degradation of ALK G1202R in 293T cells","","","94.6","Inhibition of ALK G1202R","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","789.981","789.400253112","6.4","59","9","8","2","7","132.85","C48H51N7O4","InChI=1S/C48H51N7O4/c1-4-31-26-36-38(48(2,3)45-43(44(36)57)35-13-12-30(28-49)25-39(35)50-45)27-41(31)54-19-16-33(17-20-54)53-23-21-52(22-24-53)18-7-5-6-9-32-10-8-11-34-37(32)29-55(47(34)59)40-14-15-42(56)51-46(40)58/h8,10-13,25-27,33,40,50H,4-5,7,14-24,29H2,1-3H3,(H,51,56,58)","OGAOHACYLUBWJQ-UHFFFAOYSA-N"
"2223","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","804.008","803.415903176","6.76","60","9","8","2","8","132.85","C49H53N7O4","InChI=1S/C49H53N7O4/c1-4-32-27-37-39(49(2,3)46-44(45(37)58)36-14-13-31(29-50)26-40(36)51-46)28-42(32)55-20-17-34(18-21-55)54-24-22-53(23-25-54)19-8-6-5-7-10-33-11-9-12-35-38(33)30-56(48(35)60)41-15-16-43(57)52-47(41)59/h9,11-14,26-28,34,41,51H,4-6,8,15-25,30H2,1-3H3,(H,52,57,59)","IEUADQAAUYBLGF-UHFFFAOYSA-N"
"2224","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.8","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","818.035","817.43155324","7.3","61","9","8","2","9","132.85","C50H55N7O4","InChI=1S/C50H55N7O4/c1-4-33-28-38-40(50(2,3)47-45(46(38)59)37-15-14-32(30-51)27-41(37)52-47)29-43(33)56-21-18-35(19-22-56)55-25-23-54(24-26-55)20-9-7-5-6-8-11-34-12-10-13-36-39(34)31-57(49(36)61)42-16-17-44(58)53-48(42)60/h10,12-15,27-29,35,42,52H,4-7,9,16-26,31H2,1-3H3,(H,53,58,60)","KSGJJBKNCFNWDY-UHFFFAOYSA-N"
"2225","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCCCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.6","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","832.062","831.447203304","7.84","62","9","8","2","10","132.85","C51H57N7O4","InChI=1S/C51H57N7O4/c1-4-34-29-39-41(51(2,3)48-46(47(39)60)38-16-15-33(31-52)28-42(38)53-48)30-44(34)57-22-19-36(20-23-57)56-26-24-55(25-27-56)21-10-8-6-5-7-9-12-35-13-11-14-37-40(35)32-58(50(37)62)43-17-18-45(59)54-49(43)61/h11,13-16,28-30,36,43,53H,4-8,10,17-27,32H2,1-3H3,(H,54,59,61)","MLQQXWVHLDUFNH-UHFFFAOYSA-N"
"2226","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CCCCCCCC#CC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.3","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113335","846.089","845.462853368","8.38","63","9","8","2","11","132.85","C52H59N7O4","InChI=1S/C52H59N7O4/c1-4-35-30-40-42(52(2,3)49-47(48(40)61)39-17-16-34(32-53)29-43(39)54-49)31-45(35)58-23-20-37(21-24-58)57-27-25-56(26-28-57)22-11-9-7-5-6-8-10-13-36-14-12-15-38-41(36)33-59(51(38)63)44-18-19-46(60)55-50(44)62/h12,14-17,29-31,37,44,54H,4-9,11,18-28,33H2,1-3H3,(H,55,60,62)","HERNJZQXRDANCJ-UHFFFAOYSA-N"
"2227","P00533","EGFR L858R/T790M","CRBN","","SIAIS121","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","234.4","Inhibit proliferation of H1975 cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","798.232","797.248850424","4.01","57","7","12","4","13","195.27","C39H37ClFN9O7","InChI=1S/C39H37ClFN9O7/c1-2-32(51)46-29-18-24-28(43-21-44-36(24)45-22-7-8-26(41)25(40)17-22)19-31(29)57-16-4-11-48-12-14-49(15-13-48)34(53)20-42-27-6-3-5-23-35(27)39(56)50(38(23)55)30-9-10-33(52)47-37(30)54/h2-3,5-8,17-19,21,30,42H,1,4,9-16,20H2,(H,46,51)(H,43,44,45)(H,47,52,54)","CNJATHSQDNDLIM-UHFFFAOYSA-N"
"2227","P00533","EGFR e19d","CRBN","","SIAIS121","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.999","Inhibit proliferation of PC9 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","798.232","797.248850424","4.01","57","7","12","4","13","195.27","C39H37ClFN9O7","InChI=1S/C39H37ClFN9O7/c1-2-32(51)46-29-18-24-28(43-21-44-36(24)45-22-7-8-26(41)25(40)17-22)19-31(29)57-16-4-11-48-12-14-49(15-13-48)34(53)20-42-27-6-3-5-23-35(27)39(56)50(38(23)55)30-9-10-33(52)47-37(30)54/h2-3,5-8,17-19,21,30,42H,1,4,9-16,20H2,(H,46,51)(H,43,44,45)(H,47,52,54)","CNJATHSQDNDLIM-UHFFFAOYSA-N"
"2228","P00533","EGFR L858R/T790M","CRBN","","SIAIS122","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","110.4","Inhibit proliferation of H1975 cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","812.259","811.264500488","3.92","58","7","12","4","14","195.27","C40H39ClFN9O7","InChI=1S/C40H39ClFN9O7/c1-2-33(52)47-30-20-25-29(44-22-45-37(25)46-23-7-8-27(42)26(41)19-23)21-32(30)58-18-4-13-49-14-16-50(17-15-49)35(54)11-12-43-28-6-3-5-24-36(28)40(57)51(39(24)56)31-9-10-34(53)48-38(31)55/h2-3,5-8,19-22,31,43H,1,4,9-18H2,(H,47,52)(H,44,45,46)(H,48,53,55)","CYRZHTYQRKEAID-UHFFFAOYSA-N"
"2228","P00533","EGFR e19d","CRBN","","SIAIS122","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9765","Inhibit proliferation of PC9 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","812.259","811.264500488","3.92","58","7","12","4","14","195.27","C40H39ClFN9O7","InChI=1S/C40H39ClFN9O7/c1-2-33(52)47-30-20-25-29(44-22-45-37(25)46-23-7-8-27(42)26(41)19-23)21-32(30)58-18-4-13-49-14-16-50(17-15-49)35(54)11-12-43-28-6-3-5-24-36(28)40(57)51(39(24)56)31-9-10-34(53)48-38(31)55/h2-3,5-8,19-22,31,43H,1,4,9-18H2,(H,47,52)(H,44,45,46)(H,48,53,55)","CYRZHTYQRKEAID-UHFFFAOYSA-N"
"2229","P00533","EGFR L858R/T790M","CRBN","","SIAIS123","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","209.3","Inhibit proliferation of H1975 cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","826.286","825.280150552","4.27","59","7","12","4","15","195.27","C41H41ClFN9O7","InChI=1S/C41H41ClFN9O7/c1-2-34(53)48-31-21-26-30(45-23-46-38(26)47-24-9-10-28(43)27(42)20-24)22-33(31)59-19-5-14-50-15-17-51(18-16-50)36(55)8-4-13-44-29-7-3-6-25-37(29)41(58)52(40(25)57)32-11-12-35(54)49-39(32)56/h2-3,6-7,9-10,20-23,32,44H,1,4-5,8,11-19H2,(H,48,53)(H,45,46,47)(H,49,54,56)","PTYUVGHJRRBMOG-UHFFFAOYSA-N"
"2229","P00533","EGFR e19d","CRBN","","SIAIS123","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.382","Inhibit proliferation of PC9 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","826.286","825.280150552","4.27","59","7","12","4","15","195.27","C41H41ClFN9O7","InChI=1S/C41H41ClFN9O7/c1-2-34(53)48-31-21-26-30(45-23-46-38(26)47-24-9-10-28(43)27(42)20-24)22-33(31)59-19-5-14-50-15-17-51(18-16-50)36(55)8-4-13-44-29-7-3-6-25-37(29)41(58)52(40(25)57)32-11-12-35(54)49-39(32)56/h2-3,6-7,9-10,20-23,32,44H,1,4-5,8,11-19H2,(H,48,53)(H,45,46,47)(H,49,54,56)","PTYUVGHJRRBMOG-UHFFFAOYSA-N"
"2230","P00533","EGFR L858R/T790M","CRBN","","SIAIS124","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35.4","Inhibit proliferation of H1975 cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","840.313","839.295800616","4.63","60","7","12","4","16","195.27","C42H43ClFN9O7","InChI=1S/C42H43ClFN9O7/c1-2-35(54)49-32-22-27-31(46-24-47-39(27)48-25-10-11-29(44)28(43)21-25)23-34(32)60-20-6-15-51-16-18-52(19-17-51)37(56)9-3-4-14-45-30-8-5-7-26-38(30)42(59)53(41(26)58)33-12-13-36(55)50-40(33)57/h2,5,7-8,10-11,21-24,33,45H,1,3-4,6,9,12-20H2,(H,49,54)(H,46,47,48)(H,50,55,57)","DZXXQMUFFJDNFM-UHFFFAOYSA-N"
"2230","P00533","EGFR e19d","CRBN","","SIAIS124","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.4517","Inhibit proliferation of PC9 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","840.313","839.295800616","4.63","60","7","12","4","16","195.27","C42H43ClFN9O7","InChI=1S/C42H43ClFN9O7/c1-2-35(54)49-32-22-27-31(46-24-47-39(27)48-25-10-11-29(44)28(43)21-25)23-34(32)60-20-6-15-51-16-18-52(19-17-51)37(56)9-3-4-14-45-30-8-5-7-26-38(30)42(59)53(41(26)58)33-12-13-36(55)50-40(33)57/h2,5,7-8,10-11,21-24,33,45H,1,3-4,6,9,12-20H2,(H,49,54)(H,46,47,48)(H,50,55,57)","DZXXQMUFFJDNFM-UHFFFAOYSA-N"
"2231","P00533","EGFR L858R/T790M","CRBN","","SIAIS125","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","30-50/100","","Degradation of EGFR L858R/T790M in H1975/(Ba/F3) cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22.1/71.27","Inhibit proliferation of H1975/(Ba/F3) cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","854.34","853.31145068","4.99","61","7","12","4","17","195.27","C43H45ClFN9O7","InChI=1S/C43H45ClFN9O7/c1-2-36(55)50-33-23-28-32(47-25-48-40(28)49-26-11-12-30(45)29(44)22-26)24-35(33)61-21-7-16-52-17-19-53(20-18-52)38(57)10-4-3-5-15-46-31-9-6-8-27-39(31)43(60)54(42(27)59)34-13-14-37(56)51-41(34)58/h2,6,8-9,11-12,22-25,34,46H,1,3-5,7,10,13-21H2,(H,50,55)(H,47,48,49)(H,51,56,58)","UFVWZVUFBJDPFK-UHFFFAOYSA-N"
"2231","P00533","EGFR e19d","CRBN","","SIAIS125","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","100","40","Degradation of EGFR e19d in PC9 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.603/2.123","Inhibit proliferation of PC9/HCC827 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","854.34","853.31145068","4.99","61","7","12","4","17","195.27","C43H45ClFN9O7","InChI=1S/C43H45ClFN9O7/c1-2-36(55)50-33-23-28-32(47-25-48-40(28)49-26-11-12-30(45)29(44)22-26)24-35(33)61-21-7-16-52-17-19-53(20-18-52)38(57)10-4-3-5-15-46-31-9-6-8-27-39(31)43(60)54(42(27)59)34-13-14-37(56)51-41(34)58/h2,6,8-9,11-12,22-25,34,46H,1,3-5,7,10,13-21H2,(H,50,55)(H,47,48,49)(H,51,56,58)","UFVWZVUFBJDPFK-UHFFFAOYSA-N"
"2232","P00533","EGFR L858R/T790M","CRBN","","SIAIS126","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","<30/100","","Degradation of EGFR L858R/T790M in H1975/(Ba/F3) cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","26.52/51.28","Inhibit proliferation of H1975/(Ba/F3) cells expressing EGFR L858R/T790M","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","868.367","867.327100744","5.53","62","7","12","4","18","195.27","C44H47ClFN9O7","InChI=1S/C44H47ClFN9O7/c1-2-37(56)51-34-24-29-33(48-26-49-41(29)50-27-12-13-31(46)30(45)23-27)25-36(34)62-22-8-17-53-18-20-54(21-19-53)39(58)11-5-3-4-6-16-47-32-10-7-9-28-40(32)44(61)55(43(28)60)35-14-15-38(57)52-42(35)59/h2,7,9-10,12-13,23-26,35,47H,1,3-6,8,11,14-22H2,(H,51,56)(H,48,49,50)(H,52,57,59)","YTNYTUGBAXJPBN-UHFFFAOYSA-N"
"2232","P00533","EGFR e19d","CRBN","","SIAIS126","C=CC(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCCCN1CCN(C(=O)CCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","30-100","","Degradation of EGFR e19d in PC9 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.942/1.154","Inhibit proliferation of PC9/HCC827 cells expressing EGFR e19d","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113328","868.367","867.327100744","5.53","62","7","12","4","18","195.27","C44H47ClFN9O7","InChI=1S/C44H47ClFN9O7/c1-2-37(56)51-34-24-29-33(48-26-49-41(29)50-27-12-13-31(46)30(45)23-27)25-36(34)62-22-8-17-53-18-20-54(21-19-53)39(58)11-5-3-4-6-16-47-32-10-7-9-28-40(32)44(61)55(43(28)60)35-14-15-38(57)52-42(35)59/h2,7,9-10,12-13,23-26,35,47H,1,3-6,8,11,14-22H2,(H,51,56)(H,48,49,50)(H,52,57,59)","YTNYTUGBAXJPBN-UHFFFAOYSA-N"
"2233","Q06124","SHP2","CRBN","","","C[C@@H]1OCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","863.398","862.298757144","1.36","60","7","15","6","15","253.3","C40H47ClN10O8S","InChI=1S/C40H47ClN10O8S/c1-22-34(42)40(21-59-22)12-16-50(17-13-40)28-20-46-37(35(43)48-28)60-27-7-3-6-25(33(27)41)47-30(53)11-10-29(52)45-15-19-58-18-14-44-24-5-2-4-23-32(24)39(57)51(38(23)56)26-8-9-31(54)49-36(26)55/h2-7,20,22,26,34,44H,8-19,21,42H2,1H3,(H2,43,48)(H,45,52)(H,47,53)(H,49,54,55)/t22-,26?,34+/m0/s1","NTEAWAIGDXJGEU-OOYZSISKSA-N"
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"2235","Q06124","SHP2","CRBN","","","C[C@@H]1OCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","951.504","950.35118664","1.06","66","7","17","6","21","271.76","C44H55ClN10O10S","InChI=1S/C44H55ClN10O10S/c1-26-38(46)44(25-65-26)12-16-54(17-13-44)32-24-50-41(39(47)52-32)66-31-7-3-6-29(37(31)45)51-34(57)11-10-33(56)49-15-19-63-21-23-64-22-20-62-18-14-48-28-5-2-4-27-36(28)43(61)55(42(27)60)30-8-9-35(58)53-40(30)59/h2-7,24,26,30,38,48H,8-23,25,46H2,1H3,(H2,47,52)(H,49,56)(H,51,57)(H,53,58,59)/t26-,30?,38+/m0/s1","KDRJWUGZSYLXLZ-DLMNIKOYSA-N"
"2236","Q06124","SHP2","CRBN","","ZB-S-29","C[C@@H]1OCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","6.02","","Degradation of SHP2 in MV4;11 cells after 12 h treatment","","","202","Inhibition of SHP2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","207","Inhibit growth of MV4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","979.558","978.382486768","1.77","68","7","17","6","23","271.76","C46H59ClN10O10S","InChI=1S/C46H59ClN10O10S/c1-28-40(48)46(27-67-28)14-18-56(19-15-46)34-26-52-43(41(49)54-34)68-33-9-3-8-31(39(33)47)53-36(59)13-12-35(58)51-17-5-21-65-23-25-66-24-22-64-20-4-16-50-30-7-2-6-29-38(30)45(63)57(44(29)62)32-10-11-37(60)55-42(32)61/h2-3,6-9,26,28,32,40,50H,4-5,10-25,27,48H2,1H3,(H2,49,54)(H,51,58)(H,53,59)(H,55,60,61)/t28-,32?,40+/m0/s1","GOEFYTZABOPTQD-PXUBBKKOSA-N"
"2237","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","861.426","860.319492588","2.03","60","7","14","6","15","244.07","C41H49ClN10O7S","InChI=1S/C41H49ClN10O7S/c1-23-11-12-41(35(23)43)13-17-51(18-14-41)30-22-47-38(36(44)49-30)60-29-4-2-3-27(34(29)42)48-32(54)10-9-31(53)46-16-20-59-19-15-45-24-5-6-25-26(21-24)40(58)52(39(25)57)28-7-8-33(55)50-37(28)56/h2-6,21-23,28,35,45H,7-20,43H2,1H3,(H2,44,49)(H,46,53)(H,48,54)(H,50,55,56)/t23-,28?,35-/m1/s1","JLSNWEMUWWTPIM-KVDRYJSASA-N"
"2238","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","905.479","904.345707336","1.88","63","7","15","6","18","253.3","C43H53ClN10O8S","InChI=1S/C43H53ClN10O8S/c1-25-11-12-43(37(25)45)13-17-53(18-14-43)32-24-49-40(38(46)51-32)63-31-4-2-3-29(36(31)44)50-34(56)10-9-33(55)48-16-20-62-22-21-61-19-15-47-26-5-6-27-28(23-26)42(60)54(41(27)59)30-7-8-35(57)52-39(30)58/h2-6,23-25,30,37,47H,7-22,45H2,1H3,(H2,46,51)(H,48,55)(H,50,56)(H,52,57,58)/t25-,30?,37-/m1/s1","SJNBAQWZKUDNAD-VKZZGODGSA-N"
"2239","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCOCCOCCOCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","949.532","948.371922084","1.73","66","7","16","6","21","262.53","C45H57ClN10O9S","InChI=1S/C45H57ClN10O9S/c1-27-11-12-45(39(27)47)13-17-55(18-14-45)34-26-51-42(40(48)53-34)66-33-4-2-3-31(38(33)46)52-36(58)10-9-35(57)50-16-20-64-22-24-65-23-21-63-19-15-49-28-5-6-29-30(25-28)44(62)56(43(29)61)32-7-8-37(59)54-41(32)60/h2-6,25-27,32,39,49H,7-24,47H2,1H3,(H2,48,53)(H,50,57)(H,52,58)(H,54,59,60)/t27-,32?,39-/m1/s1","MYBIISPDPGYRPZ-DNVIQZPFSA-N"
"2240","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","977.586","976.403222212","2.45","68","7","16","6","23","262.53","C47H61ClN10O9S","InChI=1S/C47H61ClN10O9S/c1-29-13-14-47(41(29)49)15-19-57(20-16-47)36-28-53-44(42(50)55-36)68-35-6-2-5-33(40(35)48)54-38(60)12-11-37(59)52-18-4-22-66-24-26-67-25-23-65-21-3-17-51-30-7-8-31-32(27-30)46(64)58(45(31)63)34-9-10-39(61)56-43(34)62/h2,5-8,27-29,34,41,51H,3-4,9-26,49H2,1H3,(H2,50,55)(H,52,59)(H,54,60)(H,56,61,62)/t29-,34?,41-/m1/s1","BQSXMYVEPJYANW-BTQVGFKXSA-N"
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"2242","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","915.562","914.402828288","5.78","64","7","13","6","19","234.84","C46H59ClN10O6S","InChI=1S/C46H59ClN10O6S/c1-28-19-20-46(40(28)48)21-25-56(26-22-46)34-27-52-43(41(49)54-34)64-33-14-10-13-31(39(33)47)53-36(59)18-17-35(58)51-24-8-6-4-2-3-5-7-23-50-30-12-9-11-29-38(30)45(63)57(44(29)62)32-15-16-37(60)55-42(32)61/h9-14,27-28,32,40,50H,2-8,15-26,48H2,1H3,(H2,49,54)(H,51,58)(H,53,59)(H,55,60,61)/t28-,32?,40-/m1/s1","KIRULSZDUJCBCC-UBGCOWMQSA-N"
"2243","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","929.589","928.418478352","6.32","65","7","13","6","20","234.84","C47H61ClN10O6S","InChI=1S/C47H61ClN10O6S/c1-29-20-21-47(41(29)49)22-26-57(27-23-47)35-28-53-44(42(50)55-35)65-34-15-11-14-32(40(34)48)54-37(60)19-18-36(59)52-25-9-7-5-3-2-4-6-8-24-51-31-13-10-12-30-39(31)46(64)58(45(30)63)33-16-17-38(61)56-43(33)62/h10-15,28-29,33,41,51H,2-9,16-27,49H2,1H3,(H2,50,55)(H,52,59)(H,54,60)(H,56,61,62)/t29-,33?,41-/m1/s1","GUMOJPSLZCHPOG-FAMRHOBNSA-N"
"2244","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","943.616","942.434128416","6.86","66","7","13","6","21","234.84","C48H63ClN10O6S","InChI=1S/C48H63ClN10O6S/c1-30-21-22-48(42(30)50)23-27-58(28-24-48)36-29-54-45(43(51)56-36)66-35-16-12-15-33(41(35)49)55-38(61)20-19-37(60)53-26-10-8-6-4-2-3-5-7-9-25-52-32-14-11-13-31-40(32)47(65)59(46(31)64)34-17-18-39(62)57-44(34)63/h11-16,29-30,34,42,52H,2-10,17-28,50H2,1H3,(H2,51,56)(H,53,60)(H,55,61)(H,57,62,63)/t30-,34?,42-/m1/s1","SLYJATVSAUKPLN-MFIZYCQYSA-N"
"2245","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCCCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","957.643","956.44977848","7.4","67","7","13","6","22","234.84","C49H65ClN10O6S","InChI=1S/C49H65ClN10O6S/c1-31-22-23-49(43(31)51)24-28-59(29-25-49)37-30-55-46(44(52)57-37)67-36-17-13-16-34(42(36)50)56-39(62)21-20-38(61)54-27-11-9-7-5-3-2-4-6-8-10-26-53-33-15-12-14-32-41(33)48(66)60(47(32)65)35-18-19-40(63)58-45(35)64/h12-17,30-31,35,43,53H,2-11,18-29,51H2,1H3,(H2,52,57)(H,54,61)(H,56,62)(H,58,63,64)/t31-,35?,43-/m1/s1","UUYHFDSQSWSESV-SIMGIXQBSA-N"
"2246","Q06124","SHP2","CRBN","","","C[C@@H]1CCC2(CCN(C3=CN=C(SC4=CC=CC(NC(=O)CCC(=O)NCCCCCCCCCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)=C4Cl)C(N)=N3)CC2)[C@@H]1N","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113341","971.67","970.465428544","7.95","68","7","13","6","23","234.84","C50H67ClN10O6S","InChI=1S/C50H67ClN10O6S/c1-32-23-24-50(44(32)52)25-29-60(30-26-50)38-31-56-47(45(53)58-38)68-37-18-14-17-35(43(37)51)57-40(63)22-21-39(62)55-28-12-10-8-6-4-2-3-5-7-9-11-27-54-34-16-13-15-33-42(34)49(67)61(48(33)66)36-19-20-41(64)59-46(36)65/h13-18,31-32,36,44,54H,2-12,19-30,52H2,1H3,(H2,53,58)(H,55,62)(H,57,63)(H,59,64,65)/t32-,36?,44-/m1/s1","PYKJVVQDTNWZFZ-GASGAZPYSA-N"
"2247","Q460N5","PARP14","CRBN","","RBN012811","O=C(CN1CCC(SCC2=NC3=CC(NC4CCCC4)=CC(F)=C3C(=O)[NH]2)CC1)NCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","5","","Degradation of PARP14 in KYSE-270 cells after 24 h treatment","","","12","IC50 was assessed by probe displacement assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/cbic.202100047","788.947","788.347980508","4.53","56","7","11","5","16","185.7","C40H49FN8O6S","InChI=1S/C40H49FN8O6S/c41-28-20-25(44-24-8-3-4-9-24)21-30-36(28)38(53)46-32(45-30)23-56-26-14-18-48(19-15-26)22-34(51)43-17-6-2-1-5-16-42-29-11-7-10-27-35(29)40(55)49(39(27)54)31-12-13-33(50)47-37(31)52/h7,10-11,20-21,24,26,31,42,44H,1-6,8-9,12-19,22-23H2,(H,43,51)(H,45,46,53)(H,47,50,52)","HTRNIXWEXIRUMI-UHFFFAOYSA-N"
"2248","Q9NYV4","CDK12","CRBN","","BSJ-4-80","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","713.195","712.252458584","3.46","51","7","10","4","12","178.72","C36H37ClN8O6","InChI=1S/C36H37ClN8O6/c37-25-18-40-36(43-32(25)24-17-39-26-10-2-1-8-22(24)26)41-21-7-6-16-44(19-21)15-4-3-14-38-30(47)20-51-28-11-5-9-23-31(28)35(50)45(34(23)49)27-12-13-29(46)42-33(27)48/h1-2,5,8-11,17-18,21,27,39H,3-4,6-7,12-16,19-20H2,(H,38,47)(H,40,41,43)(H,42,46,48)/t21-,27?/m1/s1","IPLPZBRRANOVRB-XJQHNOHDSA-N"
"2249","Q9NYV4","CDK12","CRBN","","BSJ-4-79","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","727.222","726.268108648","3.82","52","7","10","4","13","178.72","C37H39ClN8O6","InChI=1S/C37H39ClN8O6/c38-26-19-41-37(44-33(26)25-18-40-27-11-3-2-9-23(25)27)42-22-8-7-17-45(20-22)16-5-1-4-15-39-31(48)21-52-29-12-6-10-24-32(29)36(51)46(35(24)50)28-13-14-30(47)43-34(28)49/h2-3,6,9-12,18-19,22,28,40H,1,4-5,7-8,13-17,20-21H2,(H,39,48)(H,41,42,44)(H,43,47,49)/t22-,28?/m1/s1","GBSJKHPZXSUKHO-WZOMIXFGSA-N"
"2250","Q9NYV4","CDK12","CRBN","","BSJ-4-78","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","741.249","740.283758712","4.17","53","7","10","4","14","178.72","C38H41ClN8O6","InChI=1S/C38H41ClN8O6/c39-27-20-42-38(45-34(27)26-19-41-28-12-4-3-10-24(26)28)43-23-9-8-18-46(21-23)17-6-2-1-5-16-40-32(49)22-53-30-13-7-11-25-33(30)37(52)47(36(25)51)29-14-15-31(48)44-35(29)50/h3-4,7,10-13,19-20,23,29,41H,1-2,5-6,8-9,14-18,21-22H2,(H,40,49)(H,42,43,45)(H,44,48,50)/t23-,29?/m1/s1","VNGAWOXECXVZNH-WIZGVZBGSA-N"
"2251","Q9NYV4","CDK12","CRBN","","BSJ-4-23","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","9","Inhibition of CDK12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","755.276","754.299408776","4.71","54","7","10","4","15","178.72","C39H43ClN8O6","InChI=1S/C39H43ClN8O6/c40-28-21-43-39(46-35(28)27-20-42-29-13-5-4-11-25(27)29)44-24-10-9-19-47(22-24)18-7-3-1-2-6-17-41-33(50)23-54-31-14-8-12-26-34(31)38(53)48(37(26)52)30-15-16-32(49)45-36(30)51/h4-5,8,11-14,20-21,24,30,42H,1-3,6-7,9-10,15-19,22-23H2,(H,41,50)(H,43,44,46)(H,45,49,51)/t24-,30?/m1/s1","GVXKUINUYLVQFZ-DDAUYOFQSA-N"
"2251","Q9NYV4","CDK12 C1039F","CRBN","","BSJ-4-23","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","755.276","754.299408776","4.71","54","7","10","4","15","178.72","C39H43ClN8O6","InChI=1S/C39H43ClN8O6/c40-28-21-43-39(46-35(28)27-20-42-29-13-5-4-11-25(27)29)44-24-10-9-19-47(22-24)18-7-3-1-2-6-17-41-33(50)23-54-31-14-8-12-26-34(31)38(53)48(37(26)52)30-15-16-32(49)45-36(30)51/h4-5,8,11-14,20-21,24,30,42H,1-3,6-7,9-10,15-19,22-23H2,(H,41,50)(H,43,44,46)(H,45,49,51)/t24-,30?/m1/s1","GVXKUINUYLVQFZ-DDAUYOFQSA-N"
"2252","Q9NYV4","CDK12","CRBN","","BSJ-4-98","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","773.247","772.273587952","2.45","55","7","12","4","16","197.18","C38H41ClN8O8","InChI=1S/C38H41ClN8O8/c39-27-20-42-38(45-34(27)26-19-41-28-8-2-1-6-24(26)28)43-23-5-4-13-46(21-23)14-16-54-18-17-53-15-12-40-32(49)22-55-30-9-3-7-25-33(30)37(52)47(36(25)51)29-10-11-31(48)44-35(29)50/h1-3,6-9,19-20,23,29,41H,4-5,10-18,21-22H2,(H,40,49)(H,42,43,45)(H,44,48,50)/t23-,29?/m1/s1","IETJBBZPLGKKMZ-WIZGVZBGSA-N"
"2253","Q9NYV4","CDK12","CRBN","","BSJ-4-26","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCOCCN1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","817.3","816.2998027","2.3","58","7","13","4","19","206.41","C40H45ClN8O9","InChI=1S/C40H45ClN8O9/c41-29-22-44-40(47-36(29)28-21-43-30-8-2-1-6-26(28)30)45-25-5-4-13-48(23-25)14-16-56-18-20-57-19-17-55-15-12-42-34(51)24-58-32-9-3-7-27-35(32)39(54)49(38(27)53)31-10-11-33(50)46-37(31)52/h1-3,6-9,21-22,25,31,43H,4-5,10-20,23-24H2,(H,42,51)(H,44,45,47)(H,46,50,52)/t25-,31?/m1/s1","WZKAMLOXUTULFP-KZQYXEPFSA-N"
"2254","Q9NYV4","CDK12","CRBN","","BSJ-4-71","O=C(COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCC[C@@H](NC2=NC=C(Cl)C(C3=C[NH]C4=CC=CC=C34)=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","755.232","754.263023268","3.21","54","7","10","4","13","195.79","C38H39ClN8O7","InChI=1S/C38H39ClN8O7/c39-26-19-42-38(45-34(26)25-18-41-27-11-4-3-9-23(25)27)43-22-8-7-17-46(20-22)32(50)13-2-1-5-16-40-31(49)21-54-29-12-6-10-24-33(29)37(53)47(36(24)52)28-14-15-30(48)44-35(28)51/h3-4,6,9-12,18-19,22,28,41H,1-2,5,7-8,13-17,20-21H2,(H,40,49)(H,42,43,45)(H,44,48,51)/t22-,28?/m1/s1","BLZHFXKCPPBRAD-WZOMIXFGSA-N"
"2255","Q9NYV4","CDK12","CRBN","","BSJ-4-116","CC(C)S(=O)(=O)C1=CC=CC=C1NC1=NC(N[C@@H]2CCCN(CCCCCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)=NC=C1Cl","","","","","","6","Inhibition of CDK12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","837.4","836.308259208","5.39","58","6","13","4","18","209.1","C40H49ClN8O8S","InChI=1S/C40H49ClN8O8S/c1-25(2)58(55,56)32-16-7-6-14-29(32)45-36-28(41)22-43-40(47-36)44-26-12-11-21-48(23-26)20-9-5-3-4-8-19-42-34(51)24-57-31-15-10-13-27-35(31)39(54)49(38(27)53)30-17-18-33(50)46-37(30)52/h6-7,10,13-16,22,25-26,30H,3-5,8-9,11-12,17-21,23-24H2,1-2H3,(H,42,51)(H,46,50,52)(H2,43,44,45,47)/t26-,30?/m1/s1","YJOJMGTVKMABKQ-FIQOPJFZSA-N"
"2255","Q9NYV4","CDK12 C1039F","CRBN","","BSJ-4-116","CC(C)S(=O)(=O)C1=CC=CC=C1NC1=NC(N[C@@H]2CCCN(CCCCCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)=NC=C1Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41589-021-00765-y","837.4","836.308259208","5.39","58","6","13","4","18","209.1","C40H49ClN8O8S","InChI=1S/C40H49ClN8O8S/c1-25(2)58(55,56)32-16-7-6-14-29(32)45-36-28(41)22-43-40(47-36)44-26-12-11-21-48(23-26)20-9-5-3-4-8-19-42-34(51)24-57-31-15-10-13-27-35(31)39(54)49(38(27)53)30-17-18-33(50)46-37(30)52/h6-7,10,13-16,22,25-26,30H,3-5,8-9,11-12,17-21,23-24H2,1-2H3,(H,42,51)(H,46,50,52)(H2,43,44,45,47)/t26-,30?/m1/s1","YJOJMGTVKMABKQ-FIQOPJFZSA-N"
"2256","P62942","FKBP12","DCAF11","","21-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCOCCOCCOCCCN(C(=O)CCl)C(C(=O)NCC2=CC=CC=C2)C2=CC=C(Cl)C(Cl)=C2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c00990","1154.623","1152.4396215","9.45","79","5","13","2","34","197.57","C59H75Cl3N4O13","InChI=1S/C59H75Cl3N4O13/c1-6-59(2,3)55(69)57(71)65-27-11-10-19-48(65)58(72)79-49(24-20-41-21-25-50(73-4)51(35-41)74-5)43-17-12-18-45(36-43)78-40-52(67)63-26-13-29-75-31-33-77-34-32-76-30-14-28-66(53(68)38-60)54(44-22-23-46(61)47(62)37-44)56(70)64-39-42-15-8-7-9-16-42/h7-9,12,15-18,21-23,25,35-37,48-49,54H,6,10-11,13-14,19-20,24,26-34,38-40H2,1-5H3,(H,63,67)(H,64,70)/t48-,49+,54?/m0/s1","GOMFDWHIAWKFSP-MABACLQESA-N"
"2257","P62942","FKBP12","DCAF11","","10-SLF","CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1=CC=C(OC)C(OC)=C1)C1=CC=CC(OCC(=O)NCCCOCCOCCOCCCN(C(=O)CCl)C(C(=O)NCC2=CC=CC=C2)C2=CC=C(Cl)C=C2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c00990","1120.178","1118.47859385","8.82","78","5","13","2","34","197.57","C59H76Cl2N4O13","InChI=1S/C59H76Cl2N4O13/c1-6-59(2,3)55(68)57(70)64-29-11-10-19-48(64)58(71)78-49(26-20-42-21-27-50(72-4)51(37-42)73-5)45-17-12-18-47(38-45)77-41-52(66)62-28-13-31-74-33-35-76-36-34-75-32-14-30-65(53(67)39-60)54(44-22-24-46(61)25-23-44)56(69)63-40-43-15-8-7-9-16-43/h7-9,12,15-18,21-25,27,37-38,48-49,54H,6,10-11,13-14,19-20,26,28-36,39-41H2,1-5H3,(H,62,66)(H,63,69)/t48-,49+,54?/m0/s1","XVRCAVJOLKVISC-MABACLQESA-N"
"2258","P10275","AR","DCAF11","","21-ARL","CC1(C)[C@H](NC(=O)C2=CC=C(OCC(=O)NCCCOCCOCCOCCCN(C(=O)CCl)C(C(=O)NCC3=CC=CC=C3)C3=CC=C(Cl)C(Cl)=C3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c00990","1027.871","1025.30668919","8.99","69","5","10","3","27","177.55","C51H59Cl4N5O9","InChI=1S/C51H59Cl4N5O9/c1-50(2)48(51(3,4)49(50)69-39-18-14-37(31-56)41(54)29-39)59-46(63)35-12-16-38(17-13-35)68-33-43(61)57-20-8-22-65-24-26-67-27-25-66-23-9-21-60(44(62)30-52)45(36-15-19-40(53)42(55)28-36)47(64)58-32-34-10-6-5-7-11-34/h5-7,10-19,28-29,45,48-49H,8-9,20-27,30,32-33H2,1-4H3,(H,57,61)(H,58,64)(H,59,63)/t45?,48-,49-","OZJVDQBSUCNBIV-QBVMTHEVSA-N"
"2259","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","8/6.9","","Degradation of FLT3-ITD in MOLM-13/MV-4-11 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1/18.7","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","733.761","733.277258092","2.19","54","8","10","5","9","206.69","C38H36FN9O6","InChI=1S/C38H36FN9O6/c39-22-6-4-8-25-31(22)33(40)32(36(52)44-25)34-42-23-11-10-20(19-26(23)43-34)46-15-17-47(18-16-46)29(50)9-1-2-14-41-24-7-3-5-21-30(24)38(54)48(37(21)53)27-12-13-28(49)45-35(27)51/h3-8,10-11,19,27,41H,1-2,9,12-18H2,(H,42,43)(H3,40,44,52)(H,45,49,51)","MSGCDHXTWFWAJI-UHFFFAOYSA-N"
"2260","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","7.4/9.1","","Degradation of FLT3-ITD in MOLM-13/MV-4-11 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.5/9.2","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","747.788","747.292908156","2.54","55","8","10","5","10","206.69","C39H38FN9O6","InChI=1S/C39H38FN9O6/c40-23-7-5-9-26-32(23)34(41)33(37(53)45-26)35-43-24-12-11-21(20-27(24)44-35)47-16-18-48(19-17-47)30(51)10-2-1-3-15-42-25-8-4-6-22-31(25)39(55)49(38(22)54)28-13-14-29(50)46-36(28)52/h4-9,11-12,20,28,42H,1-3,10,13-19H2,(H,43,44)(H3,41,45,53)(H,46,50,52)","LOZMISVXTOAAHE-UHFFFAOYSA-N"
"2261","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130.1/416","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","761.815","761.30855822","3.08","56","8","10","5","11","206.69","C40H40FN9O6","InChI=1S/C40H40FN9O6/c41-24-8-6-10-27-33(24)35(42)34(38(54)46-27)36-44-25-13-12-22(21-28(25)45-36)48-17-19-49(20-18-48)31(52)11-3-1-2-4-16-43-26-9-5-7-23-32(26)40(56)50(39(23)55)29-14-15-30(51)47-37(29)53/h5-10,12-13,21,29,43H,1-4,11,14-20H2,(H,44,45)(H3,42,46,54)(H,47,51,53)","ALAYQUJPTDSVQC-UHFFFAOYSA-N"
"2262","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","705.707","705.245957964","1.2","52","8","10","5","7","206.69","C36H32FN9O6","InChI=1S/C36H32FN9O6/c37-20-4-2-6-23-29(20)31(38)30(34(50)42-23)32-40-21-8-7-18(17-24(21)41-32)45-15-13-44(14-16-45)12-11-27(48)39-22-5-1-3-19-28(22)36(52)46(35(19)51)25-9-10-26(47)43-33(25)49/h1-8,17,25H,9-16H2,(H,39,48)(H,40,41)(H3,38,42,50)(H,43,47,49)","VKKRIGPSDJVYDC-UHFFFAOYSA-N"
"2263","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","419.3/739.4","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","719.734","719.261608028","1.56","53","8","10","5","8","206.69","C37H34FN9O6","InChI=1S/C37H34FN9O6/c38-21-5-2-7-24-30(21)32(39)31(35(51)43-24)33-41-22-10-9-19(18-25(22)42-33)46-16-14-45(15-17-46)13-3-8-27(48)40-23-6-1-4-20-29(23)37(53)47(36(20)52)26-11-12-28(49)44-34(26)50/h1-2,4-7,9-10,18,26H,3,8,11-17H2,(H,40,48)(H,41,42)(H3,39,43,51)(H,44,49,50)","UMQWXLBJOSAXMY-UHFFFAOYSA-N"
"2264","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/726.5","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","733.761","733.277258092","1.92","54","8","10","5","9","206.69","C38H36FN9O6","InChI=1S/C38H36FN9O6/c39-22-6-4-8-25-31(22)33(40)32(36(52)44-25)34-42-23-11-10-20(19-26(23)43-34)47-17-15-46(16-18-47)14-2-1-9-28(49)41-24-7-3-5-21-30(24)38(54)48(37(21)53)27-12-13-29(50)45-35(27)51/h3-8,10-11,19,27H,1-2,9,12-18H2,(H,41,49)(H,42,43)(H3,40,44,52)(H,45,50,51)","KWMVFIYCDIGBJW-UHFFFAOYSA-N"
"2265","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/556.7","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","747.788","747.292908156","2.27","55","8","10","5","10","206.69","C39H38FN9O6","InChI=1S/C39H38FN9O6/c40-23-7-5-9-26-32(23)34(41)33(37(53)45-26)35-43-24-12-11-21(20-27(24)44-35)48-18-16-47(17-19-48)15-3-1-2-10-29(50)42-25-8-4-6-22-31(25)39(55)49(38(22)54)28-13-14-30(51)46-36(28)52/h4-9,11-12,20,28H,1-3,10,13-19H2,(H,42,50)(H,43,44)(H3,41,45,53)(H,46,51,52)","RSESWEUQQUPLAV-UHFFFAOYSA-N"
"2266","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/418.2","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","761.815","761.30855822","2.82","56","8","10","5","11","206.69","C40H40FN9O6","InChI=1S/C40H40FN9O6/c41-24-8-6-10-27-33(24)35(42)34(38(54)46-27)36-44-25-13-12-22(21-28(25)45-36)49-19-17-48(18-20-49)16-4-2-1-3-11-30(51)43-26-9-5-7-23-32(26)40(56)50(39(23)55)29-14-15-31(52)47-37(29)53/h5-10,12-13,21,29H,1-4,11,14-20H2,(H,43,51)(H,44,45)(H3,42,46,54)(H,47,52,53)","MKLIPOOSBQXLOL-UHFFFAOYSA-N"
"2267","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCCCCC(=O)NC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","775.842","775.324208284","3.36","57","8","10","5","12","206.69","C41H42FN9O6","InChI=1S/C41H42FN9O6/c42-25-9-7-11-28-34(25)36(43)35(39(55)47-28)37-45-26-14-13-23(22-29(26)46-37)50-20-18-49(19-21-50)17-5-3-1-2-4-12-31(52)44-27-10-6-8-24-33(27)41(57)51(40(24)56)30-15-16-32(53)48-38(30)54/h6-11,13-14,22,30H,1-5,12,15-21H2,(H,44,52)(H,45,46)(H3,43,47,55)(H,48,53,54)","SDNNVCQSPHQJDG-UHFFFAOYSA-N"
"2268","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","751/>1000","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","719.778","719.297993536","1.42","53","8","9","5","9","189.62","C38H38FN9O5","InChI=1S/C38H38FN9O5/c39-24-6-4-8-27-32(24)34(40)33(37(52)44-27)35-42-26-11-10-21(19-28(26)43-35)47-17-15-46(16-18-47)14-2-1-9-30(49)41-25-7-3-5-22-23(25)20-48(38(22)53)29-12-13-31(50)45-36(29)51/h3-8,10-11,19,29H,1-2,9,12-18,20H2,(H,41,49)(H,42,43)(H3,40,44,52)(H,45,50,51)","FGEPJCJEJZBHSR-UHFFFAOYSA-N"
"2269","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","733.805","733.3136436","1.78","54","8","9","5","10","189.62","C39H40FN9O5","InChI=1S/C39H40FN9O5/c40-25-7-5-9-28-33(25)35(41)34(38(53)45-28)36-43-27-12-11-22(20-29(27)44-36)48-18-16-47(17-19-48)15-3-1-2-10-31(50)42-26-8-4-6-23-24(26)21-49(39(23)54)30-13-14-32(51)46-37(30)52/h4-9,11-12,20,30H,1-3,10,13-19,21H2,(H,42,50)(H,43,44)(H3,41,45,53)(H,46,51,52)","ABNRLHXEGSFTOH-UHFFFAOYSA-N"
"2270","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(CCCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/>1000","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","747.832","747.329293664","2.32","55","8","9","5","11","189.62","C40H42FN9O5","InChI=1S/C40H42FN9O5/c41-26-8-6-10-29-34(26)36(42)35(39(54)46-29)37-44-28-13-12-23(21-30(28)45-37)49-19-17-48(18-20-49)16-4-2-1-3-11-32(51)43-27-9-5-7-24-25(27)22-50(40(24)55)31-14-15-33(52)47-38(31)53/h5-10,12-13,21,31H,1-4,11,14-20,22H2,(H,43,51)(H,44,45)(H3,42,46,54)(H,47,52,53)","BMDZCHNTNZSYPA-UHFFFAOYSA-N"
"2271","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000/928.9","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","714.714","714.235058932","1.59","53","8","9","4","5","194.66","C38H31FN8O6","InChI=1S/C38H31FN8O6/c39-23-8-4-9-25-31(23)33(40)32(36(51)43-25)34-41-24-12-11-21(19-26(24)42-34)45-15-17-46(18-16-45)29(49)10-2-1-5-20-6-3-7-22-30(20)38(53)47(37(22)52)27-13-14-28(48)44-35(27)50/h3-4,6-9,11-12,19,27H,2,10,13-18H2,(H,41,42)(H3,40,43,51)(H,44,48,50)","PCTRWKFVLMELTN-UHFFFAOYSA-N"
"2272","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","93.7/424.3","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","728.741","728.250708996","1.95","54","8","9","4","6","194.66","C39H33FN8O6","InChI=1S/C39H33FN8O6/c40-24-9-5-10-26-32(24)34(41)33(37(52)44-26)35-42-25-13-12-22(20-27(25)43-35)46-16-18-47(19-17-46)30(50)11-3-1-2-6-21-7-4-8-23-31(21)39(54)48(38(23)53)28-14-15-29(49)45-36(28)51/h4-5,7-10,12-13,20,28H,1,3,11,14-19H2,(H,42,43)(H3,41,44,52)(H,45,49,51)","HLVMDGIAWMCBJX-UHFFFAOYSA-N"
"2273","P36888","FLT3-ITD","CRBN","","","NC1=C(C2=NC3=CC(N4CCN(C(=O)CCCCC#CC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=CC=C3[NH]2)C(=O)[NH]C2=CC=CC(F)=C12","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","306.2/634.7","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","742.768","742.26635906","2.49","55","8","9","4","7","194.66","C40H35FN8O6","InChI=1S/C40H35FN8O6/c41-25-10-6-11-27-33(25)35(42)34(38(53)45-27)36-43-26-14-13-23(21-28(26)44-36)47-17-19-48(20-18-47)31(51)12-4-2-1-3-7-22-8-5-9-24-32(22)40(55)49(39(24)54)29-15-16-30(50)46-37(29)52/h5-6,8-11,13-14,21,29H,1-2,4,12,15-20H2,(H,43,44)(H3,42,45,53)(H,46,50,52)","GSLXVSBBXQHFFY-UHFFFAOYSA-N"
"2274","P36888","FLT3-ITD","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCC(=O)N3CCN(C4=CC=C5[NH]C(C6=C(N)C7=C(F)C=CC=C7[NH]C6=O)=NC5=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","184.9/415","Inhibit proliferation of MOLM-13/MV-4-11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00996","919.097","918.4010787","3.77","66","8","11","6","13","222.74","C48H55FN10O6S","InChI=1S/C48H55FN10O6S/c1-27-42(66-26-52-27)29-14-12-28(13-15-29)24-51-45(63)36-23-31(60)25-59(36)47(65)43(48(2,3)4)56-37(61)10-5-6-11-38(62)58-20-18-57(19-21-58)30-16-17-33-35(22-30)54-44(53-33)40-41(50)39-32(49)8-7-9-34(39)55-46(40)64/h7-9,12-17,22,26,31,36,43,60H,5-6,10-11,18-21,23-25H2,1-4H3,(H,51,63)(H,53,54)(H,56,61)(H3,50,55,64)/t31-,36+,43-/m1/s1","LGHDRYKGWNDSFU-ZZRHNPQXSA-N"
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"2314","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","7/40/47/32","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","808.38","807.35111","6.94","58","7","10","3","13","164.18","C44H50ClN7O6","InChI=1S/C44H50ClN7O6/c1-43(2)41(44(3,4)42(43)58-30-16-13-28(26-46)32(45)25-30)49-37(54)27-11-14-29(15-12-27)51-23-21-50(22-24-51)20-7-5-6-19-47-33-10-8-9-31-36(33)40(57)52(39(31)56)34-17-18-35(53)48-38(34)55/h8-16,25,34,41-42,47H,5-7,17-24H2,1-4H3,(H,49,54)(H,48,53,55)/t34?,41-,42-","BCKKOFRJGPPGFK-PCLMCWKJSA-N"
"2315","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","54/77/91/73","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","778.31","777.304159808","5.29","56","8","10","2","8","155.39","C42H44ClN7O6","InChI=1S/C42H44ClN7O6/c1-41(2)39(42(3,4)40(41)56-29-11-7-25(21-44)32(43)20-29)46-35(52)24-5-8-26(9-6-24)47-15-17-48(18-16-47)28-22-49(23-28)27-10-12-30-31(19-27)38(55)50(37(30)54)33-13-14-34(51)45-36(33)53/h5-12,19-20,28,33,39-40H,13-18,22-23H2,1-4H3,(H,46,52)(H,45,51,53)/t33?,39-,40-","TVNUXMHVPSQCNZ-YEKULVGXSA-N"
"2316","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","0.15/5.08","","Degradation of AR in VCaP/LNCaP cells after 24 h treatment","64/96/98/90","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7/10","Inhibit growth of VCaP/LNCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","792.337","791.319809872","5.48","57","8","10","2","9","155.39","C43H46ClN7O6","InChI=1S/C43H46ClN7O6/c1-42(2)40(43(3,4)41(42)57-30-11-7-27(21-45)33(44)20-30)47-36(53)26-5-8-28(9-6-26)49-17-15-48(16-18-49)22-25-23-50(24-25)29-10-12-31-32(19-29)39(56)51(38(31)55)34-13-14-35(52)46-37(34)54/h5-12,19-20,25,34,40-41H,13-18,22-24H2,1-4H3,(H,47,53)(H,46,52,54)/t34?,40-,41-","NYTQWRHXSYHGSP-RPINAMIVSA-N"
"2317","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","0.76/1.41","","Degradation of AR in VCaP/LNCaP cells after 24 h treatment","79/93/85/55","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8/11","Inhibit growth of VCaP/LNCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","806.364","805.335459936","6.01","58","8","10","2","8","155.39","C44H48ClN7O6","InChI=1S/C44H48ClN7O6/c1-43(2)41(44(3,4)42(43)58-31-11-7-27(25-46)34(45)24-31)48-37(54)26-5-8-28(9-6-26)50-19-21-51(22-20-50)29-15-17-49(18-16-29)30-10-12-32-33(23-30)40(57)52(39(32)56)35-13-14-36(53)47-38(35)55/h5-12,23-24,29,35,41-42H,13-22H2,1-4H3,(H,48,54)(H,47,53,55)/t35?,41-,42-","GOJVIZZNCNOPSJ-ZOVDNBRGSA-N"
"2318","P10275","AR","CRBN","","ARD-2128","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","0.28/8.3","","Degradation of AR in VCaP/LNCaP cells after 24 h treatment","62/94/98/96","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4/5","Inhibit growth of VCaP/LNCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","820.391","819.35111","6.2","59","8","10","2","9","155.39","C45H50ClN7O6","InChI=1S/C45H50ClN7O6/c1-44(2)42(45(3,4)43(44)59-32-11-7-29(25-47)35(46)24-32)49-38(55)28-5-8-30(9-6-28)52-21-19-50(20-22-52)26-27-15-17-51(18-16-27)31-10-12-33-34(23-31)41(58)53(40(33)57)36-13-14-37(54)48-39(36)56/h5-12,23-24,27,36,42-43H,13-22,26H2,1-4H3,(H,49,55)(H,48,54,56)/t36?,42-,43-","BWDWHHAZFQBJQL-JABICJEXSA-N"
"2319","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C(=O)N3CCN(C4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","71/83/95/83","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","806.32","805.299074428","4.63","58","8","10","2","8","172.46","C43H44ClN7O7","InChI=1S/C43H44ClN7O7/c1-42(2)40(43(3,4)41(42)58-29-11-9-26(21-45)32(44)20-29)47-35(53)24-5-7-25(8-6-24)37(55)49-17-15-48(16-18-49)28-22-50(23-28)27-10-12-30-31(19-27)39(57)51(38(30)56)33-13-14-34(52)46-36(33)54/h5-12,19-20,28,33,40-41H,13-18,22-23H2,1-4H3,(H,47,53)(H,46,52,54)/t33?,40-,41-","GSBDPSRAZIBNMI-IVBVVVCDSA-N"
"2320","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C(=O)N3CCN(CC4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","65/92/96/79","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","820.347","819.314724492","4.82","59","8","10","2","9","172.46","C44H46ClN7O7","InChI=1S/C44H46ClN7O7/c1-43(2)41(44(3,4)42(43)59-30-11-9-28(21-46)33(45)20-30)48-36(54)26-5-7-27(8-6-26)38(56)50-17-15-49(16-18-50)22-25-23-51(24-25)29-10-12-31-32(19-29)40(58)52(39(31)57)34-13-14-35(53)47-37(34)55/h5-12,19-20,25,34,41-42H,13-18,22-24H2,1-4H3,(H,48,54)(H,47,53,55)/t34?,41-,42-","PMCUCRVADOBCSR-PCLMCWKJSA-N"
"2321","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C(=O)N3CCN(C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","85/97/96/83","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","834.374","833.330374556","5.34","60","8","10","2","8","172.46","C45H48ClN7O7","InChI=1S/C45H48ClN7O7/c1-44(2)42(45(3,4)43(44)60-31-11-9-28(25-47)34(46)24-31)49-37(55)26-5-7-27(8-6-26)39(57)52-21-19-51(20-22-52)29-15-17-50(18-16-29)30-10-12-32-33(23-30)41(59)53(40(32)58)35-13-14-36(54)48-38(35)56/h5-12,23-24,29,35,42-43H,13-22H2,1-4H3,(H,49,55)(H,48,54,56)/t35?,42-,43-","IFHFBUGVHCIJNP-SGHVCNSHSA-N"
"2322","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(C(=O)N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","76/97/97/96","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","848.401","847.34602462","5.54","61","8","10","2","9","172.46","C46H50ClN7O7","InChI=1S/C46H50ClN7O7/c1-45(2)43(46(3,4)44(45)61-32-11-9-30(25-48)35(47)24-32)50-38(56)28-5-7-29(8-6-28)40(58)53-21-19-51(20-22-53)26-27-15-17-52(18-16-27)31-10-12-33-34(23-31)42(60)54(41(33)59)36-13-14-37(55)49-39(36)57/h5-12,23-24,27,36,43-44H,13-22,26H2,1-4H3,(H,50,56)(H,49,55,57)/t36?,43-,44-","DHRLIGMURBNFBV-GFQMCGJDSA-N"
"2323","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","0.12/1.43","","Degradation of AR in VCaP/LNCaP cells after 24 h treatment","57/93/96/85","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4/14","Inhibit growth of VCaP/LNCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","806.364","805.335459936","6.01","58","8","10","2","8","155.39","C44H48ClN7O6","InChI=1S/C44H48ClN7O6/c1-43(2)41(44(3,4)42(43)58-31-11-7-27(25-46)34(45)24-31)48-37(54)26-5-8-28(9-6-26)49-17-15-29(16-18-49)50-19-21-51(22-20-50)30-10-12-32-33(23-30)40(57)52(39(32)56)35-13-14-36(53)47-38(35)55/h5-12,23-24,29,35,41-42H,13-22H2,1-4H3,(H,48,54)(H,47,53,55)/t35?,41-,42-","IBPGCZDPTQXMHO-ZOVDNBRGSA-N"
"2324","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCC(CN4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","0.38/3.38","","Degradation of AR in VCaP/LNCaP cells after 24 h treatment","40/96/99/99","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5/13","Inhibit growth of VCaP/LNCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","820.391","819.35111","6.2","59","8","10","2","9","155.39","C45H50ClN7O6","InChI=1S/C45H50ClN7O6/c1-44(2)42(45(3,4)43(44)59-32-11-7-29(25-47)35(46)24-32)49-38(55)28-5-8-30(9-6-28)51-17-15-27(16-18-51)26-50-19-21-52(22-20-50)31-10-12-33-34(23-31)41(58)53(40(33)57)36-13-14-37(54)48-39(36)56/h5-12,23-24,27,36,42-43H,13-22,26H2,1-4H3,(H,49,55)(H,48,54,56)/t36?,42-,43-","ARVBJCZQRUZZDE-JABICJEXSA-N"
"2325","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CC5(C4)CN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C4)C5)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","37/78/93/88","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","818.375","817.335459936","5.9","59","9","10","2","8","155.39","C45H48ClN7O6","InChI=1S/C45H48ClN7O6/c1-43(2)41(44(3,4)42(43)59-31-11-7-27(23-47)34(46)20-31)49-37(55)26-5-8-28(9-6-26)50-15-17-51(18-16-50)30-21-45(22-30)24-52(25-45)29-10-12-32-33(19-29)40(58)53(39(32)57)35-13-14-36(54)48-38(35)56/h5-12,19-20,30,35,41-42H,13-18,21-22,24-25H2,1-4H3,(H,49,55)(H,48,54,56)/t35?,41-,42-","GXQKKLUWLOIBAM-ZOVDNBRGSA-N"
"2326","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CC5(C4)CN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C4)C5)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","30/82/97/95","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","832.402","831.35111","6.09","60","9","10","2","9","155.39","C46H50ClN7O6","InChI=1S/C46H50ClN7O6/c1-44(2)42(45(3,4)43(44)60-32-11-7-29(23-48)35(47)20-32)50-38(56)28-5-8-30(9-6-28)52-17-15-51(16-18-52)24-27-21-46(22-27)25-53(26-46)31-10-12-33-34(19-31)41(59)54(40(33)58)36-13-14-37(55)49-39(36)57/h5-12,19-20,27,36,42-43H,13-18,21-22,24-26H2,1-4H3,(H,50,56)(H,49,55,57)/t36?,42-,43-","DMBURQWZRJNBLX-JABICJEXSA-N"
"2327","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CC5(CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","38/80/87/84","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","832.402","831.35111","6.25","60","9","10","2","8","155.39","C46H50ClN7O6","InChI=1S/C46H50ClN7O6/c1-44(2)42(45(3,4)43(44)60-32-11-7-28(25-48)35(47)22-32)50-38(56)27-5-8-29(9-6-27)51-17-19-52(20-18-51)31-23-46(24-31)15-16-53(26-46)30-10-12-33-34(21-30)41(59)54(40(33)58)36-13-14-37(55)49-39(36)57/h5-12,21-22,31,36,42-43H,13-20,23-24,26H2,1-4H3,(H,50,56)(H,49,55,57)/t31?,36?,42-,43-,46?","UHARXTYMRNQSKR-OOONLIELSA-N"
"2328","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CC5(CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)C4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","16/56/71/51","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","846.429","845.366760064","6.45","61","9","10","2","9","155.39","C47H52ClN7O6","InChI=1S/C47H52ClN7O6/c1-45(2)43(46(3,4)44(45)61-33-11-7-30(25-49)36(48)22-33)51-39(57)29-5-8-31(9-6-29)53-19-17-52(18-20-53)26-28-23-47(24-28)15-16-54(27-47)32-10-12-34-35(21-32)42(60)55(41(34)59)37-13-14-38(56)50-40(37)58/h5-12,21-22,28,37,43-44H,13-20,23-24,26-27H2,1-4H3,(H,51,57)(H,50,56,58)/t28?,37?,43-,44-,47?","DCOGPZJUOQBADY-LMJMDUSLSA-N"
"2329","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CCC5(CC4)CCN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C4)CC5)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","14/38/67/80","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","874.483","873.398060192","7.33","63","9","10","2","8","155.39","C49H56ClN7O6","InChI=1S/C49H56ClN7O6/c1-47(2)45(48(3,4)46(47)63-35-11-7-31(29-51)38(50)28-35)53-41(59)30-5-8-32(9-6-30)55-23-25-56(26-24-55)33-15-17-49(18-16-33)19-21-54(22-20-49)34-10-12-36-37(27-34)44(62)57(43(36)61)39-13-14-40(58)52-42(39)60/h5-12,27-28,33,39,45-46H,13-26H2,1-4H3,(H,53,59)(H,52,58,60)/t39?,45-,46-","YSPGTJUSEGQJII-QBCKCKNJSA-N"
"2330","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(C4CCC5(CC4)CN(C4=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C4)C5)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","15/48/73/82","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","846.429","845.366760064","6.61","61","9","10","2","8","155.39","C47H52ClN7O6","InChI=1S/C47H52ClN7O6/c1-45(2)43(46(3,4)44(45)61-33-11-7-29(25-49)36(48)24-33)51-39(57)28-5-8-30(9-6-28)52-19-21-53(22-20-52)31-15-17-47(18-16-31)26-54(27-47)32-10-12-34-35(23-32)42(60)55(41(34)59)37-13-14-38(56)50-40(37)58/h5-12,23-24,31,37,43-44H,13-22,26-27H2,1-4H3,(H,51,57)(H,50,56,58)/t37?,43-,44-","NTTPTYCXQDIWQW-CKLCFHENSA-N"
"2331","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCC4(CC3)CC(NC3=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C3)C4)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","0/16/82/88","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","777.322","776.30891084","6.66","56","8","9","3","8","160.94","C43H45ClN6O6","InChI=1S/C43H45ClN6O6/c1-41(2)39(42(3,4)40(41)56-29-11-7-25(23-45)32(44)20-29)48-35(52)24-5-9-28(10-6-24)49-17-15-43(16-18-49)21-27(22-43)46-26-8-12-30-31(19-26)38(55)50(37(30)54)33-13-14-34(51)47-36(33)53/h5-12,19-20,27,33,39-40,46H,13-18,21-22H2,1-4H3,(H,48,52)(H,47,51,53)/t33?,39-,40-","BSJZNQXMKMMAHE-YEKULVGXSA-N"
"2332","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCC4(CCC(NC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","13/30/38/57","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","805.376","804.340210968","7.38","58","8","9","3","8","160.94","C45H49ClN6O6","InChI=1S/C45H49ClN6O6/c1-43(2)41(44(3,4)42(43)58-31-11-7-27(25-47)34(46)24-31)50-37(54)26-5-9-30(10-6-26)51-21-19-45(20-22-51)17-15-28(16-18-45)48-29-8-12-32-33(23-29)40(57)52(39(32)56)35-13-14-36(53)49-38(35)55/h5-12,23-24,28,35,41-42,48H,13-22H2,1-4H3,(H,50,54)(H,49,53,55)/t35?,41-,42-","GOPLBBMERRSJEP-ZOVDNBRGSA-N"
"2333","P10275","AR","CRBN","","","CC1(C)[C@@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C[C@@H]1OC1=CC=C(C#N)C(Cl)=C1","","","","<5/19/75/90","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","792.337","791.319809872","5.37","57","8","10","2","9","155.39","C43H46ClN7O6","InChI=1S/C43H46ClN7O6/c1-43(2)36(23-37(43)57-31-9-5-28(24-45)34(44)22-31)46-39(53)27-3-6-29(7-4-27)50-19-17-48(18-20-50)25-26-13-15-49(16-14-26)30-8-10-32-33(21-30)42(56)51(41(32)55)35-11-12-38(52)47-40(35)54/h3-10,21-22,26,35-37H,11-20,23,25H2,1-2H3,(H,46,53)(H,47,52,54)/t35?,36-,37-/m0/s1","OPOHRULPDHWIMA-JXFJOITASA-N"
"2334","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2C[C@H](NC(=O)C3=CC=C(N4CCN(CC5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)C2)C=C1Cl","","","","<5/30/25/39","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","764.283","763.288509744","4.53","55","8","10","2","9","155.39","C41H42ClN7O6","InChI=1S/C41H42ClN7O6/c42-35-22-31(7-3-27(35)23-43)55-32-19-28(20-32)44-38(51)26-1-4-29(5-2-26)48-17-15-46(16-18-48)24-25-11-13-47(14-12-25)30-6-8-33-34(21-30)41(54)49(40(33)53)36-9-10-37(50)45-39(36)52/h1-8,21-22,25,28,32,36H,9-20,24H2,(H,44,51)(H,45,50,52)/t28-,32-,36?","KZBHLBPCXLIZLA-XUEBMSRXSA-N"
"2335","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(F)=C1","","","","<5/15/75/80","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","803.936","803.38066054","5.67","59","8","10","2","9","155.39","C45H50FN7O6","InChI=1S/C45H50FN7O6/c1-44(2)42(45(3,4)43(44)59-32-11-7-29(25-47)35(46)24-32)49-38(55)28-5-8-30(9-6-28)52-21-19-50(20-22-52)26-27-15-17-51(18-16-27)31-10-12-33-34(23-31)41(58)53(40(33)57)36-13-14-37(54)48-39(36)56/h5-12,23-24,27,36,42-43H,13-22,26H2,1-4H3,(H,49,55)(H,48,54,56)/t36?,42-,43-","VNIUIQUONIMGCZ-JABICJEXSA-N"
"2336","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CC=C(C#N)C(C(F)(F)F)=C1","","","","22/45/87/90","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","853.943","853.37746698","6.45","62","8","10","2","9","155.39","C46H50F3N7O6","InChI=1S/C46H50F3N7O6/c1-44(2)42(45(3,4)43(44)62-32-11-7-29(25-50)35(24-32)46(47,48)49)52-38(58)28-5-8-30(9-6-28)55-21-19-53(20-22-55)26-27-15-17-54(18-16-27)31-10-12-33-34(23-31)41(61)56(40(33)60)36-13-14-37(57)51-39(36)59/h5-12,23-24,27,36,42-43H,13-22,26H2,1-4H3,(H,52,58)(H,51,57,59)/t36?,42-,43-","SKXRXOCDOMSQPQ-JABICJEXSA-N"
"2337","P10275","AR","CRBN","","","CC1(C)[C@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)C(C)(C)[C@H]1OC1=CN=C(C#N)C(C(F)(F)F)=C1","","","","6/12/33/41","% AR degradation in VCaP cells after 6 h treatment at 1/10/100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00882","854.931","854.372715948","5.72","62","8","11","2","9","168.28","C45H49F3N8O6","InChI=1S/C45H49F3N8O6/c1-43(2)41(44(3,4)42(43)62-30-22-33(45(46,47)48)34(23-49)50-24-30)52-37(58)27-5-7-28(8-6-27)55-19-17-53(18-20-55)25-26-13-15-54(16-14-26)29-9-10-31-32(21-29)40(61)56(39(31)60)35-11-12-36(57)51-38(35)59/h5-10,21-22,24,26,35,41-42H,11-20,25H2,1-4H3,(H,52,58)(H,51,57,59)/t35?,41-,42-","ABSBBQRJBGJPAQ-ZOVDNBRGSA-N"
"2338","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","158.5","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","98","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","100/398.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.5","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","1000.689","999.390215004","6.18","69","7","14","4","20","202.26","C50H62ClN9O7S2","InChI=1S/C50H62ClN9O7S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)55-38(46-58-57-32(4)60(46)49)24-40(62)52-19-22-66-20-9-8-10-21-67-27-41(63)56-45(50(5,6)7)48(65)59-26-37(61)23-39(59)47(64)53-25-33-11-13-35(14-12-33)44-30(2)54-28-68-44/h11-18,28,37-39,45,61H,8-10,19-27H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t37-,38+,39+,45-/m1/s1","PWFGHENEZLVBOP-DPSJZEHMSA-N"
"2338","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","158.5","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","98","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","100/398.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1000.689","999.390215004","6.18","69","7","14","4","20","202.26","C50H62ClN9O7S2","InChI=1S/C50H62ClN9O7S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)55-38(46-58-57-32(4)60(46)49)24-40(62)52-19-22-66-20-9-8-10-21-67-27-41(63)56-45(50(5,6)7)48(65)59-26-37(61)23-39(59)47(64)53-25-33-11-13-35(14-12-33)44-30(2)54-28-68-44/h11-18,28,37-39,45,61H,8-10,19-27H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t37-,38+,39+,45-/m1/s1","PWFGHENEZLVBOP-DPSJZEHMSA-N"
"2338","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","125.89 ","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","98","FP","","","","","","","","","","","","","","","3.7","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","100/398.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1000.689","999.390215004","6.18","69","7","14","4","20","202.26","C50H62ClN9O7S2","InChI=1S/C50H62ClN9O7S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)55-38(46-58-57-32(4)60(46)49)24-40(62)52-19-22-66-20-9-8-10-21-67-27-41(63)56-45(50(5,6)7)48(65)59-26-37(61)23-39(59)47(64)53-25-33-11-13-35(14-12-33)44-30(2)54-28-68-44/h11-18,28,37-39,45,61H,8-10,19-27H2,1-7H3,(H,52,62)(H,53,64)(H,56,63)/t37-,38+,39+,45-/m1/s1","PWFGHENEZLVBOP-DPSJZEHMSA-N"
"2339","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","251.2","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","66","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","199.5/631","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.08","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","972.635","971.358914876","5.47","67","7","14","4","18","202.26","C48H58ClN9O7S2","InChI=1S/C48H58ClN9O7S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)53-36(44-56-55-30(4)58(44)47)22-38(60)50-17-20-64-18-8-19-65-25-39(61)54-43(48(5,6)7)46(63)57-24-35(59)21-37(57)45(62)51-23-31-9-11-33(12-10-31)42-28(2)52-26-66-42/h9-16,26,35-37,43,59H,8,17-25H2,1-7H3,(H,50,60)(H,51,62)(H,54,61)/t35-,36+,37+,43-/m1/s1","MJCKFIWZHNIKPQ-AYWQWSHZSA-N"
"2339","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","199.5","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","66","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","199.5/631","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","972.635","971.358914876","5.47","67","7","14","4","18","202.26","C48H58ClN9O7S2","InChI=1S/C48H58ClN9O7S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)53-36(44-56-55-30(4)58(44)47)22-38(60)50-17-20-64-18-8-19-65-25-39(61)54-43(48(5,6)7)46(63)57-24-35(59)21-37(57)45(62)51-23-31-9-11-33(12-10-31)42-28(2)52-26-66-42/h9-16,26,35-37,43,59H,8,17-25H2,1-7H3,(H,50,60)(H,51,62)(H,54,61)/t35-,36+,37+,43-/m1/s1","MJCKFIWZHNIKPQ-AYWQWSHZSA-N"
"2339","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","125.89 ","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","66","FP","","","","","","","","","","","","","","","3","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","199.5/631","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","972.635","971.358914876","5.47","67","7","14","4","18","202.26","C48H58ClN9O7S2","InChI=1S/C48H58ClN9O7S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)53-36(44-56-55-30(4)58(44)47)22-38(60)50-17-20-64-18-8-19-65-25-39(61)54-43(48(5,6)7)46(63)57-24-35(59)21-37(57)45(62)51-23-31-9-11-33(12-10-31)42-28(2)52-26-66-42/h9-16,26,35-37,43,59H,8,17-25H2,1-7H3,(H,50,60)(H,51,62)(H,54,61)/t35-,36+,37+,43-/m1/s1","MJCKFIWZHNIKPQ-AYWQWSHZSA-N"
"2340","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","125.9","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","248","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","199.5/794.3","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.1","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","1003.645","1002.35349515","5.54","69","7","16","3","20","208.69","C49H59ClN8O9S2","InChI=1S/C49H59ClN8O9S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)53-37(45-56-55-31(4)58(45)48)23-40(61)67-21-20-65-17-16-64-18-19-66-26-39(60)54-44(49(5,6)7)47(63)57-25-36(59)22-38(57)46(62)51-24-32-8-10-34(11-9-32)43-29(2)52-27-68-43/h8-15,27,36-38,44,59H,16-26H2,1-7H3,(H,51,62)(H,54,60)/t36-,37+,38+,44-/m1/s1","HZTRWCKQNKXISW-PYNGZGNASA-N"
"2340","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","199.5","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","248","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","199.5/794.3","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1003.645","1002.35349515","5.54","69","7","16","3","20","208.69","C49H59ClN8O9S2","InChI=1S/C49H59ClN8O9S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)53-37(45-56-55-31(4)58(45)48)23-40(61)67-21-20-65-17-16-64-18-19-66-26-39(60)54-44(49(5,6)7)47(63)57-25-36(59)22-38(57)46(62)51-24-32-8-10-34(11-9-32)43-29(2)52-27-68-43/h8-15,27,36-38,44,59H,16-26H2,1-7H3,(H,51,62)(H,54,60)/t36-,37+,38+,44-/m1/s1","HZTRWCKQNKXISW-PYNGZGNASA-N"
"2340","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","39.81 ","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","248","FP","","","","","","","","","","","","","","","6.4","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","199.5/794.3","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1003.645","1002.35349515","5.54","69","7","16","3","20","208.69","C49H59ClN8O9S2","InChI=1S/C49H59ClN8O9S2/c1-28-30(3)69-48-41(28)42(33-12-14-35(50)15-13-33)53-37(45-56-55-31(4)58(45)48)23-40(61)67-21-20-65-17-16-64-18-19-66-26-39(60)54-44(49(5,6)7)47(63)57-25-36(59)22-38(57)46(62)51-24-32-8-10-34(11-9-32)43-29(2)52-27-68-43/h8-15,27,36-38,44,59H,16-26H2,1-7H3,(H,51,62)(H,54,60)/t36-,37+,38+,44-/m1/s1","HZTRWCKQNKXISW-PYNGZGNASA-N"
"2341","P25440","BRD2","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","1.3","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","63","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","4/63.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.3","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","987.646","986.358580528","6.45","68","7","15","3","18","199.46","C49H59ClN8O8S2","InChI=1S/C49H59ClN8O8S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)53-37(45-56-55-31(5)58(45)48)23-40(61)66-21-20-64-18-9-19-65-25-39(60)54-44(49(6,7)8)47(63)57-24-36(59)22-38(57)46(62)52-28(2)32-10-12-34(13-11-32)43-29(3)51-26-67-43/h10-17,26,28,36-38,44,59H,9,18-25H2,1-8H3,(H,52,62)(H,54,60)/t28-,36+,37-,38-,44+/m0/s1","CWTFXHWWWKKEQI-QQRWPDCKSA-N"
"2341","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","4.0","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","63","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","4/63.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","987.646","986.358580528","6.45","68","7","15","3","18","199.46","C49H59ClN8O8S2","InChI=1S/C49H59ClN8O8S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)53-37(45-56-55-31(5)58(45)48)23-40(61)66-21-20-64-18-9-19-65-25-39(60)54-44(49(6,7)8)47(63)57-24-36(59)22-38(57)46(62)52-28(2)32-10-12-34(13-11-32)43-29(3)51-26-67-43/h10-17,26,28,36-38,44,59H,9,18-25H2,1-8H3,(H,52,62)(H,54,60)/t28-,36+,37-,38-,44+/m0/s1","CWTFXHWWWKKEQI-QQRWPDCKSA-N"
"2341","O60885","BRD4","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","6.31 ","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","63","FP","","","","","","","","","","","","","","","7.3","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","4/63.1","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","987.646","986.358580528","6.45","68","7","15","3","18","199.46","C49H59ClN8O8S2","InChI=1S/C49H59ClN8O8S2/c1-27-30(4)68-48-41(27)42(33-14-16-35(50)17-15-33)53-37(45-56-55-31(5)58(45)48)23-40(61)66-21-20-64-18-9-19-65-25-39(60)54-44(49(6,7)8)47(63)57-24-36(59)22-38(57)46(62)52-28(2)32-10-12-34(13-11-32)43-29(3)51-26-67-43/h10-17,26,28,36-38,44,59H,9,18-25H2,1-8H3,(H,52,62)(H,54,60)/t28-,36+,37-,38-,44+/m0/s1","CWTFXHWWWKKEQI-QQRWPDCKSA-N"
"2342","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","79.4","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","236","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","125.9/316.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.2","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","1001.673","1000.37423059","6.76","69","7","15","3","20","199.46","C50H61ClN8O8S2","InChI=1S/C50H61ClN8O8S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)54-38(46-57-56-32(4)59(46)49)24-41(62)67-22-21-65-19-9-8-10-20-66-27-40(61)55-45(50(5,6)7)48(64)58-26-37(60)23-39(58)47(63)52-25-33-11-13-35(14-12-33)44-30(2)53-28-68-44/h11-18,28,37-39,45,60H,8-10,19-27H2,1-7H3,(H,52,63)(H,55,61)/t37-,38+,39+,45-/m1/s1","VRVWHAZIBGEPEK-DPSJZEHMSA-N"
"2342","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","100.0","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","236","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","125.9/316.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1001.673","1000.37423059","6.76","69","7","15","3","20","199.46","C50H61ClN8O8S2","InChI=1S/C50H61ClN8O8S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)54-38(46-57-56-32(4)59(46)49)24-41(62)67-22-21-65-19-9-8-10-20-66-27-40(61)55-45(50(5,6)7)48(64)58-26-37(60)23-39(58)47(63)52-25-33-11-13-35(14-12-33)44-30(2)53-28-68-44/h11-18,28,37-39,45,60H,8-10,19-27H2,1-7H3,(H,52,63)(H,55,61)/t37-,38+,39+,45-/m1/s1","VRVWHAZIBGEPEK-DPSJZEHMSA-N"
"2342","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","63.10 ","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","236","FP","","","","","","","","","","","","","","","18","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","125.9/316.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","1001.673","1000.37423059","6.76","69","7","15","3","20","199.46","C50H61ClN8O8S2","InChI=1S/C50H61ClN8O8S2/c1-29-31(3)69-49-42(29)43(34-15-17-36(51)18-16-34)54-38(46-57-56-32(4)59(46)49)24-41(62)67-22-21-65-19-9-8-10-20-66-27-40(61)55-45(50(5,6)7)48(64)58-26-37(60)23-39(58)47(63)52-25-33-11-13-35(14-12-33)44-30(2)53-28-68-44/h11-18,28,37-39,45,60H,8-10,19-27H2,1-7H3,(H,52,63)(H,55,61)/t37-,38+,39+,45-/m1/s1","VRVWHAZIBGEPEK-DPSJZEHMSA-N"
"2343","P25440","BRD2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","63.1","","Degradation of BRD2 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","143","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","50.1/251.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","0.6","PAMPA assay","","","","","10.1021/acs.jmedchem.1c01496","973.619","972.342930464","6.04","67","7","15","3","18","199.46","C48H57ClN8O8S2","InChI=1S/C48H57ClN8O8S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)52-36(44-55-54-30(4)57(44)47)22-39(60)65-20-19-63-17-8-18-64-25-38(59)53-43(48(5,6)7)46(62)56-24-35(58)21-37(56)45(61)50-23-31-9-11-33(12-10-31)42-28(2)51-26-66-42/h9-16,26,35-37,43,58H,8,17-25H2,1-7H3,(H,50,61)(H,53,59)/t35-,36+,37+,43-/m1/s1","SZLZPTHXIDWXLS-AYWQWSHZSA-N"
"2343","Q15059","BRD3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","63.1","","Degradation of BRD3 in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","143","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","50.1/251.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","973.619","972.342930464","6.04","67","7","15","3","18","199.46","C48H57ClN8O8S2","InChI=1S/C48H57ClN8O8S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)52-36(44-55-54-30(4)57(44)47)22-39(60)65-20-19-63-17-8-18-64-25-38(59)53-43(48(5,6)7)46(62)56-24-35(58)21-37(56)45(61)50-23-31-9-11-33(12-10-31)42-28(2)51-26-66-42/h9-16,26,35-37,43,58H,8,17-25H2,1-7H3,(H,50,61)(H,53,59)/t35-,36+,37+,43-/m1/s1","SZLZPTHXIDWXLS-AYWQWSHZSA-N"
"2343","O60885","BRD4","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCOCCOC(=O)C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C4=C(SC(C)=C4C)N4C(C)=NN=C34)C(C)(C)C)C=C2)SC=N1","31.62","","Degradation of BRD4 long in HEK293 cells after 4 h treatment","","","","","","","","","","","","","","","","","","","","","","","143","FP","","","","","","","","","","","","","","","21","Kd between VHL and the complex of protac and BRD4 BD2 was tested by FP","","","","","","","","","","","50.1/251.2","Inhibit proliferation of MV4;11/22Rv1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01496","973.619","972.342930464","6.04","67","7","15","3","18","199.46","C48H57ClN8O8S2","InChI=1S/C48H57ClN8O8S2/c1-27-29(3)67-47-40(27)41(32-13-15-34(49)16-14-32)52-36(44-55-54-30(4)57(44)47)22-39(60)65-20-19-63-17-8-18-64-25-38(59)53-43(48(5,6)7)46(62)56-24-35(58)21-37(56)45(61)50-23-31-9-11-33(12-10-31)42-28(2)51-26-66-42/h9-16,26,35-37,43,58H,8,17-25H2,1-7H3,(H,50,61)(H,53,59)/t35-,36+,37+,43-/m1/s1","SZLZPTHXIDWXLS-AYWQWSHZSA-N"
"2344","P33981","TTK","VHL","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCOCCC(=O)N[C@@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)CC1",">1000","","Degradation of TTK in HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","1048.325","1047.5364293","4.82","75","8","16","5","19","225.48","C55H73N11O8S","InChI=1S/C55H73N11O8S/c1-8-46(68)59-38-13-15-39(16-14-38)66-48(70)27-34(2)42-31-57-54(62-51(42)66)60-43-18-17-40(28-45(43)73-7)64-22-20-63(21-23-64)24-26-74-25-19-47(69)61-50(55(4,5)6)53(72)65-32-41(67)29-44(65)52(71)56-30-36-9-11-37(12-10-36)49-35(3)58-33-75-49/h9-12,17-18,27-28,31,33,38-39,41,44,50,67H,8,13-16,19-26,29-30,32H2,1-7H3,(H,56,71)(H,59,68)(H,61,69)(H,57,60,62)/t38-,39+,41-,44+,50+/m1/s1","SUUSSNMSFOIMTM-QWALSHNLSA-N"
"2345","P33981","TTK","VHL","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCOCCC(=O)N[C@@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)CC1",">1000","","Degradation of TTK in HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","1076.379","1075.56772942","5.53","77","8","16","5","21","225.48","C57H77N11O8S","InChI=1S/C57H77N11O8S/c1-8-48(70)61-40-15-17-41(18-16-40)68-50(72)29-36(2)44-33-59-56(64-53(44)68)62-45-20-19-42(30-47(45)75-7)66-25-23-65(24-26-66)22-9-10-27-76-28-21-49(71)63-52(57(4,5)6)55(74)67-34-43(69)31-46(67)54(73)58-32-38-11-13-39(14-12-38)51-37(3)60-35-77-51/h11-14,19-20,29-30,33,35,40-41,43,46,52,69H,8-10,15-18,21-28,31-32,34H2,1-7H3,(H,58,73)(H,61,70)(H,63,71)(H,59,62,64)/t40-,41+,43-,46+,52+/m1/s1","MPXCMWJVCZZWNP-NWFHPFIOSA-N"
"2346","P33981","TTK","VHL","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCOCCC(=O)N[C@@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)CC1",">1000","","Degradation of TTK in HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","1104.433","1103.59902955","6.25","79","8","16","5","23","225.48","C59H81N11O8S","InChI=1S/C59H81N11O8S/c1-8-50(72)63-42-17-19-43(20-18-42)70-52(74)31-38(2)46-35-61-58(66-55(46)70)64-47-22-21-44(32-49(47)77-7)68-27-25-67(26-28-68)24-11-9-10-12-29-78-30-23-51(73)65-54(59(4,5)6)57(76)69-36-45(71)33-48(69)56(75)60-34-40-13-15-41(16-14-40)53-39(3)62-37-79-53/h13-16,21-22,31-32,35,37,42-43,45,48,54,71H,8-12,17-20,23-30,33-34,36H2,1-7H3,(H,60,75)(H,63,72)(H,65,73)(H,61,64,66)/t42-,43+,45-,48+,54+/m1/s1","MKPDBPCFJYIBSR-RUIVAHQKSA-N"
"2347","P33981","TTK","VHL","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(CCCCCCCCOCCC(=O)N[C@@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4OC)N=C32)CC1",">1000","","Degradation of TTK in HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","1132.487","1131.63032968","7.33","81","8","16","5","25","225.48","C61H85N11O8S","InChI=1S/C61H85N11O8S/c1-8-52(74)65-44-19-21-45(22-20-44)72-54(76)33-40(2)48-37-63-60(68-57(48)72)66-49-24-23-46(34-51(49)79-7)70-29-27-69(28-30-70)26-13-11-9-10-12-14-31-80-32-25-53(75)67-56(61(4,5)6)59(78)71-38-47(73)35-50(71)58(77)62-36-42-15-17-43(18-16-42)55-41(3)64-39-81-55/h15-18,23-24,33-34,37,39,44-45,47,50,56,73H,8-14,19-22,25-32,35-36,38H2,1-7H3,(H,62,77)(H,65,74)(H,67,75)(H,63,66,68)/t44-,45+,47-,50+,56+/m1/s1","HGGXUMRGGKLPIH-BLKJDWLZSA-N"
"2348","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCC#CC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)CC1","598.7/>1000","28/43","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","855.997","855.406795036","3.31","63","8","12","3","11","188.17","C47H53N9O7","InChI=1S/C47H53N9O7/c1-4-40(57)49-31-13-15-32(16-14-31)56-43(60)25-29(2)35-27-48-47(52-44(35)56)50-37-18-17-33(26-39(37)63-3)53-21-23-54(24-22-53)42(59)12-7-5-6-9-30-10-8-11-34-36(30)28-55(46(34)62)38-19-20-41(58)51-45(38)61/h8,10-11,17-18,25-27,31-32,38H,4-5,7,12-16,19-24,28H2,1-3H3,(H,49,57)(H,48,50,52)(H,51,58,61)/t31-,32+,38?","ILIHAEQFLUWMRH-HSWALOBVSA-N"
"2349","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCC#CC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)CC1","4.97/20.3","76/50","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","884.051","883.438095164","4.39","65","8","12","3","13","188.17","C49H57N9O7","InChI=1S/C49H57N9O7/c1-4-42(59)51-33-15-17-34(18-16-33)58-45(62)27-31(2)37-29-50-49(54-46(37)58)52-39-20-19-35(28-41(39)65-3)55-23-25-56(26-24-55)44(61)14-9-7-5-6-8-11-32-12-10-13-36-38(32)30-57(48(36)64)40-21-22-43(60)53-47(40)63/h10,12-13,19-20,27-29,33-34,40H,4-7,9,14-18,21-26,30H2,1-3H3,(H,51,59)(H,50,52,54)(H,53,60,63)/t33-,34+,40?","QEDFXQXPBXHVGU-RMDMJGLRSA-N"
"2350","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCC#CC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)CC1","7.05/58.1","84/53","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","912.105","911.469395292","5.47","67","8","12","3","15","188.17","C51H61N9O7","InChI=1S/C51H61N9O7/c1-4-44(61)53-35-17-19-36(20-18-35)60-47(64)29-33(2)39-31-52-51(56-48(39)60)54-41-22-21-37(30-43(41)67-3)57-25-27-58(28-26-57)46(63)16-11-9-7-5-6-8-10-13-34-14-12-15-38-40(34)32-59(50(38)66)42-23-24-45(62)55-49(42)65/h12,14-15,21-22,29-31,35-36,42H,4-9,11,16-20,23-28,32H2,1-3H3,(H,53,61)(H,52,54,56)(H,55,62,65)/t35-,36+,42?","OEMAZTSGRNBCPF-HUPKRMINSA-N"
"2351","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCC#CC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)C=C4OC)N=C32)CC1","2.25/49.6","87/66","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","940.159","939.50069542","6.56","69","8","12","3","17","188.17","C53H65N9O7","InChI=1S/C53H65N9O7/c1-4-46(63)55-37-19-21-38(22-20-37)62-49(66)31-35(2)41-33-54-53(58-50(41)62)56-43-24-23-39(32-45(43)69-3)59-27-29-60(30-28-59)48(65)18-13-11-9-7-5-6-8-10-12-15-36-16-14-17-40-42(36)34-61(52(40)68)44-25-26-47(64)57-51(44)67/h14,16-17,23-24,31-33,37-38,44H,4-11,13,18-22,25-30,34H2,1-3H3,(H,55,63)(H,54,56,58)(H,57,64,67)/t37-,38+,44?","LUPSPQQYVRGZLI-FPDSPUJPSA-N"
"2352","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCC#CC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)CC7=C6)CC5)C=C4OC)N=C32)CC1","1.75/5.8","88/80","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","1.6","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","110","Inhibit growth of COLO-205 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","855.997","855.406795036","3.31","63","8","12","3","11","188.17","C47H53N9O7","InChI=1S/C47H53N9O7/c1-4-40(57)49-32-11-13-33(14-12-32)56-43(60)24-29(2)36-27-48-47(52-44(36)56)50-37-17-15-34(26-39(37)63-3)53-20-22-54(23-21-53)42(59)9-7-5-6-8-30-10-16-35-31(25-30)28-55(46(35)62)38-18-19-41(58)51-45(38)61/h10,15-17,24-27,32-33,38H,4-5,7,9,11-14,18-23,28H2,1-3H3,(H,49,57)(H,48,50,52)(H,51,58,61)/t32-,33+,38?","LWHJKWAUKAHIGC-YVLRYLSESA-N"
"2353","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCC#CC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)CC7=C6)CC5)C=C4OC)N=C32)CC1","1.55/35","86/61","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","884.051","883.438095164","4.39","65","8","12","3","13","188.17","C49H57N9O7","InChI=1S/C49H57N9O7/c1-4-42(59)51-34-13-15-35(16-14-34)58-45(62)26-31(2)38-29-50-49(54-46(38)58)52-39-19-17-36(28-41(39)65-3)55-22-24-56(25-23-55)44(61)11-9-7-5-6-8-10-32-12-18-37-33(27-32)30-57(48(37)64)40-20-21-43(60)53-47(40)63/h12,17-19,26-29,34-35,40H,4-7,9,11,13-16,20-25,30H2,1-3H3,(H,51,59)(H,50,52,54)(H,53,60,63)/t34-,35+,40?","WLMZSJVDMUNOHX-UKMVIOKASA-N"
"2354","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCC#CC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)CC7=C6)CC5)C=C4OC)N=C32)CC1","3.04/663","85/50","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","912.105","911.469395292","5.47","67","8","12","3","15","188.17","C51H61N9O7","InChI=1S/C51H61N9O7/c1-4-44(61)53-36-15-17-37(18-16-36)60-47(64)28-33(2)40-31-52-51(56-48(40)60)54-41-21-19-38(30-43(41)67-3)57-24-26-58(27-25-57)46(63)13-11-9-7-5-6-8-10-12-34-14-20-39-35(29-34)32-59(50(39)66)42-22-23-45(62)55-49(42)65/h14,19-21,28-31,36-37,42H,4-9,11,13,15-18,22-27,32H2,1-3H3,(H,53,61)(H,52,54,56)(H,55,62,65)/t36-,37+,42?","VGMBSGNGVRXDBY-ILWCGICZSA-N"
"2355","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCC#CC6=CC=C7C(=O)N(C8CCC(=O)NC8=O)CC7=C6)CC5)C=C4OC)N=C32)CC1","5.6/30.2","85/83","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","940.159","939.50069542","6.56","69","8","12","3","17","188.17","C53H65N9O7","InChI=1S/C53H65N9O7/c1-4-46(63)55-38-17-19-39(20-18-38)62-49(66)30-35(2)42-33-54-53(58-50(42)62)56-43-23-21-40(32-45(43)69-3)59-26-28-60(29-27-59)48(65)15-13-11-9-7-5-6-8-10-12-14-36-16-22-41-37(31-36)34-61(52(41)68)44-24-25-47(64)57-51(44)67/h16,21-23,30-33,38-39,44H,4-11,13,15,17-20,24-29,34H2,1-3H3,(H,55,63)(H,54,56,58)(H,57,64,67)/t38-,39+,44?","WNBZJWHJHXEDEO-GTFGDMOZSA-N"
"2356","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCC#CC6=CC=C7CN(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4OC)N=C32)CC1","3.31/25.4","77/57","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","855.997","855.406795036","3.31","63","8","12","3","11","188.17","C47H53N9O7","InChI=1S/C47H53N9O7/c1-4-40(57)49-32-12-14-33(15-13-32)56-43(60)24-29(2)36-27-48-47(52-44(36)56)50-37-17-16-34(26-39(37)63-3)53-20-22-54(23-21-53)42(59)9-7-5-6-8-30-10-11-31-28-55(46(62)35(31)25-30)38-18-19-41(58)51-45(38)61/h10-11,16-17,24-27,32-33,38H,4-5,7,9,12-15,18-23,28H2,1-3H3,(H,49,57)(H,48,50,52)(H,51,58,61)/t32-,33+,38?","IJOXNAXACYQBRL-YVLRYLSESA-N"
"2357","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCC#CC6=CC=C7CN(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4OC)N=C32)CC1","3.15/12.4","82/77","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","6.5","Kd was determined by the KINOMEscan assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","250","Inhibit growth of COLO-205 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","884.051","883.438095164","4.39","65","8","12","3","13","188.17","C49H57N9O7","InChI=1S/C49H57N9O7/c1-4-42(59)51-34-14-16-35(17-15-34)58-45(62)26-31(2)38-29-50-49(54-46(38)58)52-39-19-18-36(28-41(39)65-3)55-22-24-56(25-23-55)44(61)11-9-7-5-6-8-10-32-12-13-33-30-57(48(64)37(33)27-32)40-20-21-43(60)53-47(40)63/h12-13,18-19,26-29,34-35,40H,4-7,9,11,14-17,20-25,30H2,1-3H3,(H,51,59)(H,50,52,54)(H,53,60,63)/t34-,35+,40?","XWOZFCIASHOPCP-UKMVIOKASA-N"
"2358","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCC#CC6=CC=C7CN(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4OC)N=C32)CC1","7.03/161","84/43","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","912.105","911.469395292","5.47","67","8","12","3","15","188.17","C51H61N9O7","InChI=1S/C51H61N9O7/c1-4-44(61)53-36-16-18-37(19-17-36)60-47(64)28-33(2)40-31-52-51(56-48(40)60)54-41-21-20-38(30-43(41)67-3)57-24-26-58(27-25-57)46(63)13-11-9-7-5-6-8-10-12-34-14-15-35-32-59(50(66)39(35)29-34)42-22-23-45(62)55-49(42)65/h14-15,20-21,28-31,36-37,42H,4-9,11,13,16-19,22-27,32H2,1-3H3,(H,53,61)(H,52,54,56)(H,55,62,65)/t36-,37+,42?","ILQRGGWQVGLOSJ-ILWCGICZSA-N"
"2359","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCC#CC6=CC=C7CN(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4OC)N=C32)CC1","19.09/74.5","87/66","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","940.159","939.50069542","6.56","69","8","12","3","17","188.17","C53H65N9O7","InChI=1S/C53H65N9O7/c1-4-46(63)55-38-18-20-39(21-19-38)62-49(66)30-35(2)42-33-54-53(58-50(42)62)56-43-23-22-40(32-45(43)69-3)59-26-28-60(29-27-59)48(65)15-13-11-9-7-5-6-8-10-12-14-36-16-17-37-34-61(52(68)41(37)31-36)44-24-25-47(64)57-51(44)67/h16-17,22-23,30-33,38-39,44H,4-11,13,15,18-21,24-29,34H2,1-3H3,(H,55,63)(H,54,56,58)(H,57,64,67)/t38-,39+,44?","DTEBXQFNWWUSPH-GTFGDMOZSA-N"
"2360","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCC#CC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)C=C4OC)N=C32)CC1","30.28/>1000","64/28","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","855.997","855.406795036","3.31","63","8","12","3","11","188.17","C47H53N9O7","InChI=1S/C47H53N9O7/c1-4-39(57)49-32-13-15-33(16-14-32)56-42(60)25-29(2)35-27-48-47(52-44(35)56)50-36-18-17-34(26-38(36)63-3)53-21-23-54(24-22-53)41(59)12-7-5-6-9-30-10-8-11-31-28-55(46(62)43(30)31)37-19-20-40(58)51-45(37)61/h8,10-11,17-18,25-27,32-33,37H,4-5,7,12-16,19-24,28H2,1-3H3,(H,49,57)(H,48,50,52)(H,51,58,61)/t32-,33+,37?","RPGBSIRPMJGXHN-MBSVEICTSA-N"
"2361","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCC#CC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)C=C4OC)N=C32)CC1","31.35/>1000","72/41","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","884.051","883.438095164","4.39","65","8","12","3","13","188.17","C49H57N9O7","InChI=1S/C49H57N9O7/c1-4-41(59)51-34-15-17-35(18-16-34)58-44(62)27-31(2)37-29-50-49(54-46(37)58)52-38-20-19-36(28-40(38)65-3)55-23-25-56(26-24-55)43(61)14-9-7-5-6-8-11-32-12-10-13-33-30-57(48(64)45(32)33)39-21-22-42(60)53-47(39)63/h10,12-13,19-20,27-29,34-35,39H,4-7,9,14-18,21-26,30H2,1-3H3,(H,51,59)(H,50,52,54)(H,53,60,63)/t34-,35+,39?","QKBCJYTUWJPJPK-DMBNOJOPSA-N"
"2362","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCC#CC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)C=C4OC)N=C32)CC1","46/496","73/37","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","912.105","911.469395292","5.47","67","8","12","3","15","188.17","C51H61N9O7","InChI=1S/C51H61N9O7/c1-4-43(61)53-36-17-19-37(20-18-36)60-46(64)29-33(2)39-31-52-51(56-48(39)60)54-40-22-21-38(30-42(40)67-3)57-25-27-58(28-26-57)45(63)16-11-9-7-5-6-8-10-13-34-14-12-15-35-32-59(50(66)47(34)35)41-23-24-44(62)55-49(41)65/h12,14-15,21-22,29-31,36-37,41H,4-9,11,16-20,23-28,32H2,1-3H3,(H,53,61)(H,52,54,56)(H,55,62,65)/t36-,37+,41?","ZPUBDTHTIYULJM-WFMPFVDOSA-N"
"2363","P33981","TTK","CRBN","","","CCC(=O)N[C@H]1CC[C@@H](N2C(=O)C=C(C)C3=CN=C(NC4=CC=C(N5CCN(C(=O)CCCCCCCCCC#CC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7)CC5)C=C4OC)N=C32)CC1","21.71/>1000","88/13","Degradation of TTK in COLO-205/HCT-116 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01768","940.159","939.50069542","6.56","69","8","12","3","17","188.17","C53H65N9O7","InChI=1S/C53H65N9O7/c1-4-45(63)55-38-19-21-39(22-20-38)62-48(66)31-35(2)41-33-54-53(58-50(41)62)56-42-24-23-40(32-44(42)69-3)59-27-29-60(30-28-59)47(65)18-13-11-9-7-5-6-8-10-12-15-36-16-14-17-37-34-61(52(68)49(36)37)43-25-26-46(64)57-51(43)67/h14,16-17,23-24,31-33,38-39,43H,4-11,13,18-22,25-30,34H2,1-3H3,(H,55,63)(H,54,56,58)(H,57,64,67)/t38-,39+,43?","RFDZITCLUUJECZ-FRBFHYLZSA-N"
"2364","O43353","RIPK2","IAP","","","CC[C@@H](NC(=O)[C@@H]1C[C@H](NC(=O)COCCOCCOCCOCCOC2=CC3=NC=CC(NC4=CC=C5SC=NC5=C4)=C3C=C2S(=O)(=O)C(C)(C)C)CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C1=CC=CC=C1","","","","","","2","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25.12","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1075.365","1074.49184719","5.74","75","6","16","5","27","237.74","C54H74N8O11S2","InChI=1S/C54H74N8O11S2/c1-10-40(36-14-12-11-13-15-36)60-51(65)44-29-38(32-62(44)52(66)49(53(3,4)5)61-50(64)35(2)55-9)59-48(63)33-72-25-24-70-21-20-69-22-23-71-26-27-73-45-31-42-39(30-47(45)75(67,68)54(6,7)8)41(18-19-56-42)58-37-16-17-46-43(28-37)57-34-74-46/h11-19,28,30-31,34-35,38,40,44,49,55H,10,20-27,29,32-33H2,1-9H3,(H,56,58)(H,59,63)(H,60,65)(H,61,64)/t35-,38-,40+,44-,49+/m0/s1","BFYNUDSFURPMON-UONPKGOBSA-N"
"2365","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)COCCOCCOCCOCCOC2=CC3=NC=CC(NC4=CC=C5SC=NC5=C4)=C3C=C2S(=O)(=O)C(C)(C)C)CC1","","","","","","5.01","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1131.385","1130.40754618","5.8","78","8","18","3","26","229.81","C55H67FN8O11S3","InChI=1S/C55H67FN8O11S3/c1-35(57-5)52(67)62-50(54(68)64-18-6-7-45(64)53-61-44(33-76-53)51(66)37-8-10-38(56)11-9-37)36-15-19-63(20-16-36)49(65)32-74-26-25-72-22-21-71-23-24-73-27-28-75-46-31-42-40(30-48(46)78(69,70)55(2,3)4)41(14-17-58-42)60-39-12-13-47-43(29-39)59-34-77-47/h8-14,17,29-31,33-36,45,50,57H,6-7,15-16,18-28,32H2,1-5H3,(H,58,60)(H,62,67)/t35-,45-,50-/m0/s1","ZONXEAPSKLKEFI-YXNAAVGFSA-N"
"2366","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC2=CC(OCCOCCOCCOCCOC3=CC4=NC=NC(NC5=N[NH]C(C)=C5C)=C4C=C3S(=O)(=O)C(C)(C)C)=CC=C2C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","","","","","","398.11","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31.62","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1054.325","1053.5357606","6.32","75","7","15","5","23","237.32","C55H75N9O10S","InChI=1S/C55H75N9O10S/c1-34-35(2)62-63-49(34)61-50-42-30-47(75(68,69)55(7,8)9)46(31-44(42)57-33-58-50)74-27-25-72-23-21-70-20-22-71-24-26-73-40-19-18-38-29-45(52(66)59-43-17-13-15-37-14-11-12-16-41(37)43)64(32-39(38)28-40)53(67)48(54(4,5)6)60-51(65)36(3)56-10/h11-12,14,16,18-19,28,30-31,33,36,43,45,48,56H,13,15,17,20-27,29,32H2,1-10H3,(H,59,66)(H,60,65)(H2,57,58,61,62,63)/t36-,43+,45-,48+/m0/s1","LNSQOHDINOFSQK-YPVOJFEDSA-N"
"2367","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)COCCOCCOCCOCCOC2=CC3=NC=NC(NC4=N[NH]C(C)=C4C)=C3C=C2S(=O)(=O)C(C)(C)C)CC1","","","","","","158.49","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","63.1","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1093.315","1092.45727325","4.42","76","7","18","4","26","258.49","C52H69FN10O11S2","InChI=1S/C52H69FN10O11S2/c1-32-33(2)60-61-47(32)59-48-38-27-43(76(68,69)52(4,5)6)42(28-39(38)55-31-56-48)74-26-25-72-22-21-70-19-20-71-23-24-73-29-44(64)62-17-14-35(15-18-62)45(58-49(66)34(3)54-7)51(67)63-16-8-9-41(63)50-57-40(30-75-50)46(65)36-10-12-37(53)13-11-36/h10-13,27-28,30-31,34-35,41,45,54H,8-9,14-26,29H2,1-7H3,(H,58,66)(H2,55,56,59,60,61)/t34-,41-,45-/m0/s1","UVJZKHRNSISZEZ-QOCICEDNSA-N"
"2368","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCC(COC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","10","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25.12","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1078.311","1077.44771161","6.12","76","9","17","4","16","250.59","C53H64FN13O7S2","InChI=1S/C53H64FN13O7S2/c1-30-31(2)63-64-46(30)62-47-38-23-43(76(72,73)53(4,5)6)42(24-39(38)58-29-59-47)74-27-33-14-19-66(20-15-33)52-56-25-36(26-57-52)50(70)65-21-16-34(17-22-65)44(61-48(69)32(3)55-7)51(71)67-18-8-9-41(67)49-60-40(28-75-49)45(68)35-10-12-37(54)13-11-35/h10-13,23-26,28-29,32-34,41,44,55H,8-9,14-22,27H2,1-7H3,(H,61,69)(H2,58,59,62,63,64)/t32-,41-,44-/m0/s1","BOYXDQQQBLUNSC-KMTFETDRSA-N"
"2369","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCC(CCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","39.81","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.85","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1092.338","1091.46336167","6.48","77","9","17","4","17","250.59","C54H66FN13O7S2","InChI=1S/C54H66FN13O7S2/c1-31-32(2)64-65-47(31)63-48-39-25-44(77(73,74)54(4,5)6)43(26-40(39)59-30-60-48)75-24-18-34-14-20-67(21-15-34)53-57-27-37(28-58-53)51(71)66-22-16-35(17-23-66)45(62-49(70)33(3)56-7)52(72)68-19-8-9-42(68)50-61-41(29-76-50)46(69)36-10-12-38(55)13-11-36/h10-13,25-30,33-35,42,45,56H,8-9,14-24H2,1-7H3,(H,62,70)(H2,59,60,63,64,65)/t33-,42-,45-/m0/s1","SFZONKARGQSFPV-MHMDUVPPSA-N"
"2370","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCC(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","31.62","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.16","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1106.365","1105.47901174","6.84","78","9","17","4","18","250.59","C55H68FN13O7S2","InChI=1S/C55H68FN13O7S2/c1-32-33(2)65-66-48(32)64-49-40-26-45(78(74,75)55(4,5)6)44(27-41(40)60-31-61-49)76-25-9-10-35-16-21-68(22-17-35)54-58-28-38(29-59-54)52(72)67-23-18-36(19-24-67)46(63-50(71)34(3)57-7)53(73)69-20-8-11-43(69)51-62-42(30-77-51)47(70)37-12-14-39(56)15-13-37/h12-15,26-31,34-36,43,46,57H,8-11,16-25H2,1-7H3,(H,63,71)(H2,60,61,64,65,66)/t34-,43-,46-/m0/s1","OYXDEXLMRWUCBV-XWPMHPDRSA-N"
"2371","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","7.94","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1107.353","1106.4742607","5.55","78","9","18","4","18","253.83","C54H67FN14O7S2","InChI=1S/C54H67FN14O7S2/c1-32-33(2)64-65-47(32)63-48-39-26-44(78(74,75)54(4,5)6)43(27-40(39)59-31-60-48)76-25-9-17-66-21-23-68(24-22-66)53-57-28-37(29-58-53)51(72)67-19-15-35(16-20-67)45(62-49(71)34(3)56-7)52(73)69-18-8-10-42(69)50-61-41(30-77-50)46(70)36-11-13-38(55)14-12-36/h11-14,26-31,34-35,42,45,56H,8-10,15-25H2,1-7H3,(H,62,71)(H2,59,60,63,64,65)/t34-,42-,45-/m0/s1","WHRWPFLLMDQARV-IWRLWGISSA-N"
"2372","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CC=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=C2)CC1","","","","","","31.62","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.59","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1105.377","1104.48376277","6.93","78","9","16","4","18","228.05","C56H69FN12O7S2","InChI=1S/C56H69FN12O7S2/c1-34-35(2)64-65-50(34)63-51-42-30-47(78(74,75)56(4,5)6)46(31-43(42)59-33-60-51)76-29-9-21-66-25-27-67(28-26-66)41-17-13-39(14-18-41)54(72)68-23-19-37(20-24-68)48(62-52(71)36(3)58-7)55(73)69-22-8-10-45(69)53-61-44(32-77-53)49(70)38-11-15-40(57)16-12-38/h11-18,30-33,36-37,45,48,58H,8-10,19-29H2,1-7H3,(H,62,71)(H2,59,60,63,64,65)/t36-,45-,48-/m0/s1","MPGHKLADAVRJOJ-VYFIJJFHSA-N"
"2373","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CC=C(N3CCN(CCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","125.89","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1092.338","1091.46336167","5.84","77","9","17","4","17","240.94","C54H66FN13O7S2","InChI=1S/C54H66FN13O7S2/c1-32-33(2)63-64-48(32)62-49-39-27-44(77(73,74)54(4,5)6)43(28-40(39)58-31-59-49)75-26-25-65-21-23-66(24-22-65)45-15-12-37(29-57-45)52(71)67-19-16-35(17-20-67)46(61-50(70)34(3)56-7)53(72)68-18-8-9-42(68)51-60-41(30-76-51)47(69)36-10-13-38(55)14-11-36/h10-15,27-31,34-35,42,46,56H,8-9,16-26H2,1-7H3,(H,61,70)(H2,58,59,62,63,64)/t34-,42-,46-/m0/s1","YLQIGGIFOQEJNU-RTBFYXABSA-N"
"2374","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CC=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)N=C2)CC1","","","","","","10","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.94","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1106.365","1105.47901174","6.2","78","9","17","4","18","240.94","C55H68FN13O7S2","InChI=1S/C55H68FN13O7S2/c1-33-34(2)64-65-49(33)63-50-40-28-45(78(74,75)55(4,5)6)44(29-41(40)59-32-60-50)76-27-9-19-66-23-25-67(26-24-66)46-16-13-38(30-58-46)53(72)68-21-17-36(18-22-68)47(62-51(71)35(3)57-7)54(73)69-20-8-10-43(69)52-61-42(31-77-52)48(70)37-11-14-39(56)15-12-37/h11-16,28-32,35-36,43,47,57H,8-10,17-27H2,1-7H3,(H,62,71)(H2,59,60,63,64,65)/t35-,43-,47-/m0/s1","KSEDCMRCXJGJKD-YALDDLFZSA-N"
"2375","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCN(CCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)CC1","","","","","","158.49","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.85","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1093.326","1092.45861064","5.1","77","9","18","4","17","253.83","C53H65FN14O7S2","InChI=1S/C53H65FN14O7S2/c1-31-32(2)63-64-47(31)62-48-37-25-43(77(73,74)53(4,5)6)42(26-38(37)58-30-59-48)75-24-23-65-19-21-66(22-20-65)44-28-56-39(27-57-44)51(71)67-17-14-34(15-18-67)45(61-49(70)33(3)55-7)52(72)68-16-8-9-41(68)50-60-40(29-76-50)46(69)35-10-12-36(54)13-11-35/h10-13,25-30,33-34,41,45,55H,8-9,14-24H2,1-7H3,(H,61,70)(H2,58,59,62,63,64)/t33-,41-,45-/m0/s1","QQCNBUCTKXJVDF-HRZLCWCKSA-N"
"2376","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=C(F)C=C2)=CS1)C1CCN(C(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)CC1","0.13","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","12.59","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.58","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1107.353","1106.4742607","5.46","78","9","18","4","18","253.83","C54H67FN14O7S2","InChI=1S/C54H67FN14O7S2/c1-32-33(2)64-65-48(32)63-49-38-26-44(78(74,75)54(4,5)6)43(27-39(38)59-31-60-49)76-25-9-17-66-21-23-67(24-22-66)45-29-57-40(28-58-45)52(72)68-19-15-35(16-20-68)46(62-50(71)34(3)56-7)53(73)69-18-8-10-42(69)51-61-41(30-77-51)47(70)36-11-13-37(55)14-12-36/h11-14,26-31,34-35,42,46,56H,8-10,15-25H2,1-7H3,(H,62,71)(H2,59,60,63,64,65)/t34-,42-,46-/m0/s1","VXCZVPTVGMPYKY-RTBFYXABSA-N"
"2377","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C(C)(C)C","0.16","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","12.59","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.51","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1063.344","1062.55856171","5.25","76","8","16","6","17","261.76","C54H74N14O7S","InChI=1S/C54H74N14O7S/c1-32-33(2)64-65-47(32)63-48-38-26-44(76(73,74)54(7,8)9)43(27-40(38)58-31-59-48)75-24-14-19-66-20-22-67(23-21-66)45-29-56-41(28-57-45)50(70)60-36-25-42(51(71)61-39-18-13-16-35-15-11-12-17-37(35)39)68(30-36)52(72)46(53(4,5)6)62-49(69)34(3)55-10/h11-12,15,17,26-29,31,34,36,39,42,46,55H,13-14,16,18-25,30H2,1-10H3,(H,60,70)(H,61,71)(H,62,69)(H2,58,59,63,64,65)/t34-,36-,39+,42-,46+/m0/s1","LOTKOBYQNYXXQX-YJHYPDGLSA-N"
"2378","O43353","RIPK2","IAP","","","CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)C2=CN=C(N3CCN(CCCOC4=CC5=NC=NC(NC6=N[NH]C(C)=C6C)=C5C=C4S(=O)(=O)C(C)(C)C)CC3)C=N2)CC[C@H]2CC[C@@H](C(=O)N[C@@H]3CCCC4=CC=CC=C43)N2C1=O","0.1","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","6.31","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.16","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1047.301","1046.52726158","4.2","75","9","16","5","15","252.97","C53H70N14O7S","InChI=1S/C53H70N14O7S/c1-32-33(2)62-63-47(32)61-48-38-26-45(75(72,73)53(4,5)6)44(27-40(38)57-31-58-48)74-25-11-19-64-21-23-65(24-22-64)46-29-55-41(28-56-46)51(70)66-20-18-36-16-17-43(67(36)52(71)42(30-66)60-49(68)34(3)54-7)50(69)59-39-15-10-13-35-12-8-9-14-37(35)39/h8-9,12,14,26-29,31,34,36,39,42-43,54H,10-11,13,15-25,30H2,1-7H3,(H,59,69)(H,60,68)(H2,57,58,61,62,63)/t34-,36+,39+,42-,43-/m0/s1","LYHKPGCMTCWLDN-XLJSIVTLSA-N"
"2379","O43353","RIPK2","IAP","","","CC1=N[NH]C(NC2=NC=NC3=CC(OCCCN4CCN(C(=O)C5=CN=C(N6CCN(C[C@H]7CN[C@H](C)CN7CC(=O)N7CC(C)(C)C8=C7C=C(CC7=CC=C(F)C=C7)C(=O)N8C)[C@H](C)C6)N=C5)CC4)=C(S(=O)(=O)C(C)(C)C)C=C23)=C1C","0.05","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","7.94","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.51","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1144.437","1143.59642444","5.41","82","10","18","3","16","223.25","C59H78FN15O6S","InChI=1S/C59H78FN15O6S/c1-37-31-74(34-51(76)75-35-59(8,9)52-48(75)25-42(55(77)69(52)10)24-41-12-14-44(60)15-13-41)45(30-61-37)33-72-21-22-73(32-38(72)2)57-62-28-43(29-63-57)56(78)71-19-17-70(18-20-71)16-11-23-81-49-27-47-46(26-50(49)82(79,80)58(5,6)7)54(65-36-64-47)66-53-39(3)40(4)67-68-53/h12-15,25-29,36-38,45,61H,11,16-24,30-35H2,1-10H3,(H2,64,65,66,67,68)/t37-,38-,45-/m1/s1","UBVFSVDGHDABFK-KENLXIIISA-N"
"2380","O43353","RIPK2","IAP","","","CC1=N[NH]C(NC2=NC=NC3=CC(OCCCN4CCN(C(=O)C5=CN=C(N6CCN(C[C@H]7CN[C@H](C)CN7CC(=O)N7CC(C)(C)C8=NC=C(CC9=CC=C(F)C=C9)C=C87)[C@H](C)C6)N=C5)CC4)=C(S(=O)(=O)C(C)(C)C)C=C23)=C1C","0.16","","Degradation of RIPK2 in THP1 cells after 18 h treatment","","","25.12","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.3","Inhibition of MDP-stimulated TNFalpha release in human whole blood","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01118","1114.411","1113.58585975","6.17","80","10","17","3","16","214.14","C58H76FN15O5S","InChI=1S/C58H76FN15O5S/c1-37-31-73(34-51(75)74-35-58(8,9)52-48(74)24-42(27-61-52)23-41-11-13-44(59)14-12-41)45(30-60-37)33-71-20-21-72(32-38(71)2)56-62-28-43(29-63-56)55(76)70-18-16-69(17-19-70)15-10-22-79-49-26-47-46(25-50(49)80(77,78)57(5,6)7)54(65-36-64-47)66-53-39(3)40(4)67-68-53/h11-14,24-29,36-38,45,60H,10,15-23,30-35H2,1-9H3,(H2,64,65,66,67,68)/t37-,38-,45-/m1/s1","IODBOTCCGBUXBQ-KENLXIIISA-N"
"2381","Q07817","BCL-xL","VHL","","PP1","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","340.2/303.6","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1544.362","1542.56270017","11.24","105","10","18","6","29","269.09","C76H94ClF3N10O11S4","InChI=1S/C76H94ClF3N10O11S4/c1-50(52-16-18-54(19-17-52)69-51(2)82-49-103-69)83-72(95)65-42-60(91)46-90(65)73(96)70(74(3,4)5)85-68(93)15-11-10-14-67(92)81-48-75(6)32-30-63(53-20-24-57(77)25-21-53)56(44-75)45-88-34-36-89(37-35-88)59-26-22-55(23-27-59)71(94)86-105(99,100)62-28-29-64(66(43-62)104(97,98)76(78,79)80)84-58(31-33-87-38-40-101-41-39-87)47-102-61-12-8-7-9-13-61/h7-9,12-13,16-29,43,49-50,58,60,65,70,84,91H,10-11,14-15,30-42,44-48H2,1-6H3,(H,81,92)(H,83,95)(H,85,93)(H,86,94)/t50-,58+,60+,65-,70+,75?/m0/s1","DCSROWVKZVURMC-BVMOUNNPSA-N"
"2382","Q07817","BCL-xL","VHL","","PP2","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","306.8/234.2","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1558.389","1556.57835023","11.78","106","10","18","6","30","269.09","C77H96ClF3N10O11S4","InChI=1S/C77H96ClF3N10O11S4/c1-51(53-17-19-55(20-18-53)70-52(2)83-50-104-70)84-73(96)66-43-61(92)47-91(66)74(97)71(75(3,4)5)86-69(94)16-12-8-11-15-68(93)82-49-76(6)33-31-64(54-21-25-58(78)26-22-54)57(45-76)46-89-35-37-90(38-36-89)60-27-23-56(24-28-60)72(95)87-106(100,101)63-29-30-65(67(44-63)105(98,99)77(79,80)81)85-59(32-34-88-39-41-102-42-40-88)48-103-62-13-9-7-10-14-62/h7,9-10,13-14,17-30,44,50-51,59,61,66,71,85,92H,8,11-12,15-16,31-43,45-49H2,1-6H3,(H,82,93)(H,84,96)(H,86,94)(H,87,95)/t51-,59+,61+,66-,71+,76?/m0/s1","HDVFJLRLTLWSFN-WSMKYRPJSA-N"
"2383","Q07817","BCL-xL","VHL","","PP3","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","219.4/108.4","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1572.416","1570.5940003","12.32","107","10","18","6","31","269.09","C78H98ClF3N10O11S4","InChI=1S/C78H98ClF3N10O11S4/c1-52(54-18-20-56(21-19-54)71-53(2)84-51-105-71)85-74(97)67-44-62(93)48-92(67)75(98)72(76(3,4)5)87-70(95)17-13-8-7-12-16-69(94)83-50-77(6)34-32-65(55-22-26-59(79)27-23-55)58(46-77)47-90-36-38-91(39-37-90)61-28-24-57(25-29-61)73(96)88-107(101,102)64-30-31-66(68(45-64)106(99,100)78(80,81)82)86-60(33-35-89-40-42-103-43-41-89)49-104-63-14-10-9-11-15-63/h9-11,14-15,18-31,45,51-52,60,62,67,72,86,93H,7-8,12-13,16-17,32-44,46-50H2,1-6H3,(H,83,94)(H,85,97)(H,87,95)(H,88,96)/t52-,60+,62+,67-,72+,77?/m0/s1","QPOCBFNQDNDZKQ-KNVKNGAWSA-N"
"2384","Q07817","BCL-xL","VHL","","PP4","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","124.7/43.7","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1586.443","1584.60965036","12.86","108","10","18","6","32","269.09","C79H100ClF3N10O11S4","InChI=1S/C79H100ClF3N10O11S4/c1-53(55-19-21-57(22-20-55)72-54(2)85-52-106-72)86-75(98)68-45-63(94)49-93(68)76(99)73(77(3,4)5)88-71(96)18-14-9-7-8-13-17-70(95)84-51-78(6)35-33-66(56-23-27-60(80)28-24-56)59(47-78)48-91-37-39-92(40-38-91)62-29-25-58(26-30-62)74(97)89-108(102,103)65-31-32-67(69(46-65)107(100,101)79(81,82)83)87-61(34-36-90-41-43-104-44-42-90)50-105-64-15-11-10-12-16-64/h10-12,15-16,19-32,46,52-53,61,63,68,73,87,94H,7-9,13-14,17-18,33-45,47-51H2,1-6H3,(H,84,95)(H,86,98)(H,88,96)(H,89,97)/t53-,61+,63+,68-,73+,78?/m0/s1","MUEPNUZWMIAHRW-UWPVXNPMSA-N"
"2385","Q07817","BCL-xL","VHL","","PP5","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","31.6/22.6","","Degradation of BCL-xL in MOLT-4/RS4;11 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.1/23.3","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1600.47","1598.62530042","13.4","109","10","18","6","33","269.09","C80H102ClF3N10O11S4","InChI=1S/C80H102ClF3N10O11S4/c1-54(56-20-22-58(23-21-56)73-55(2)86-53-107-73)87-76(99)69-46-64(95)50-94(69)77(100)74(78(3,4)5)89-72(97)19-15-10-8-7-9-14-18-71(96)85-52-79(6)36-34-67(57-24-28-61(81)29-25-57)60(48-79)49-92-38-40-93(41-39-92)63-30-26-59(27-31-63)75(98)90-109(103,104)66-32-33-68(70(47-66)108(101,102)80(82,83)84)88-62(35-37-91-42-44-105-45-43-91)51-106-65-16-12-11-13-17-65/h11-13,16-17,20-33,47,53-54,62,64,69,74,88,95H,7-10,14-15,18-19,34-46,48-52H2,1-6H3,(H,85,96)(H,87,99)(H,89,97)(H,90,98)/t54-,62+,64+,69-,74+,79?/m0/s1","CWIUDSZQDVZITQ-AAWIYDMSSA-N"
"2386","Q07817","BCL-xL","VHL","","PP6","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","74.6/29.2","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1614.497","1612.64095049","13.95","110","10","18","6","34","269.09","C81H104ClF3N10O11S4","InChI=1S/C81H104ClF3N10O11S4/c1-55(57-21-23-59(24-22-57)74-56(2)87-54-108-74)88-77(100)70-47-65(96)51-95(70)78(101)75(79(3,4)5)90-73(98)20-16-11-9-7-8-10-15-19-72(97)86-53-80(6)37-35-68(58-25-29-62(82)30-26-58)61(49-80)50-93-39-41-94(42-40-93)64-31-27-60(28-32-64)76(99)91-110(104,105)67-33-34-69(71(48-67)109(102,103)81(83,84)85)89-63(36-38-92-43-45-106-46-44-92)52-107-66-17-13-12-14-18-66/h12-14,17-18,21-34,48,54-55,63,65,70,75,89,96H,7-11,15-16,19-20,35-47,49-53H2,1-6H3,(H,86,97)(H,88,100)(H,90,98)(H,91,99)/t55-,63+,65+,70-,75+,80?/m0/s1","YXBCSDONMAZNMC-WGWDJEQESA-N"
"2387","Q07817","BCL-xL","VHL","","PP7","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","111.8/96.3","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1628.524","1626.65660055","14.49","111","10","18","6","35","269.09","C82H106ClF3N10O11S4","InChI=1S/C82H106ClF3N10O11S4/c1-56(58-22-24-60(25-23-58)75-57(2)88-55-109-75)89-78(101)71-48-66(97)52-96(71)79(102)76(80(3,4)5)91-74(99)21-17-12-10-8-7-9-11-16-20-73(98)87-54-81(6)38-36-69(59-26-30-63(83)31-27-59)62(50-81)51-94-40-42-95(43-41-94)65-32-28-61(29-33-65)77(100)92-111(105,106)68-34-35-70(72(49-68)110(103,104)82(84,85)86)90-64(37-39-93-44-46-107-47-45-93)53-108-67-18-14-13-15-19-67/h13-15,18-19,22-35,49,55-56,64,66,71,76,90,97H,7-12,16-17,20-21,36-48,50-54H2,1-6H3,(H,87,98)(H,89,101)(H,91,99)(H,92,100)/t56-,64+,66+,71-,76+,81?/m0/s1","UVOAKHWQXMIELR-KGENNJKMSA-N"
"2388","Q07817","BCL-xL","VHL","","PP8","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCC(=O)NCC3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","333.6/409.8","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1642.551","1640.67225062","15.03","112","10","18","6","36","269.09","C83H108ClF3N10O11S4","InChI=1S/C83H108ClF3N10O11S4/c1-57(59-23-25-61(26-24-59)76-58(2)89-56-110-76)90-79(102)72-49-67(98)53-97(72)80(103)77(81(3,4)5)92-75(100)22-18-13-11-9-7-8-10-12-17-21-74(99)88-55-82(6)39-37-70(60-27-31-64(84)32-28-60)63(51-82)52-95-41-43-96(44-42-95)66-33-29-62(30-34-66)78(101)93-112(106,107)69-35-36-71(73(50-69)111(104,105)83(85,86)87)91-65(38-40-94-45-47-108-48-46-94)54-109-68-19-15-14-16-20-68/h14-16,19-20,23-36,50,56-57,65,67,72,77,91,98H,7-13,17-18,21-22,37-49,51-55H2,1-6H3,(H,88,99)(H,90,102)(H,92,100)(H,93,101)/t57-,65+,67+,72-,77+,82?/m0/s1","LNOLDFQPSZIMKA-BMNBLYSOSA-N"
"2389","Q07817","BCL-xL","VHL","","PZ703a","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NC[C@@]3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","127.4/75.2","","Degradation of BCL-xL in MOLT-4/RS4;11 cells after 16 h treatment","","","","","","","2.75","Kd was assessed by the AlphaScreen displacement binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.64","Kd between VHL and the complex of protac and BCL-xL was assessed by the AlphaScreen displacement binding assay","","","","","","","","","","","170.4/418.3","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1600.47","1598.62530042","13.4","109","10","18","6","33","269.09","C80H102ClF3N10O11S4","InChI=1S/C80H102ClF3N10O11S4/c1-54(56-20-22-58(23-21-56)73-55(2)86-53-107-73)87-76(99)69-46-64(95)50-94(69)77(100)74(78(3,4)5)89-72(97)19-15-10-8-7-9-14-18-71(96)85-52-79(6)36-34-67(57-24-28-61(81)29-25-57)60(48-79)49-92-38-40-93(41-39-92)63-30-26-59(27-31-63)75(98)90-109(103,104)66-32-33-68(70(47-66)108(101,102)80(82,83)84)88-62(35-37-91-42-44-105-45-43-91)51-106-65-16-12-11-13-17-65/h11-13,16-17,20-33,47,53-54,62,64,69,74,88,95H,7-10,14-15,18-19,34-46,48-52H2,1-6H3,(H,85,96)(H,87,99)(H,89,97)(H,90,98)/t54-,62+,64+,69-,74+,79-/m0/s1","CWIUDSZQDVZITQ-OCIVTJSKSA-N"
"2390","Q07817","BCL-xL","VHL","","PZ703b","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NC[C@]3(C)CCC(C4=CC=C(Cl)C=C4)=C(CN4CCN(C5=CC=C(C(=O)NS(=O)(=O)C6=CC=C(N[C@H](CCN7CCOCC7)CSC7=CC=CC=C7)C(S(=O)(=O)C(F)(F)F)=C6)C=C5)CC4)C3)C(C)(C)C)C=C2)SC=N1","14.3/11.6","","Degradation of BCL-xL in MOLT-4/RS4;11 cells after 16 h treatment","","","","","","","2.59","Kd was assessed by the AlphaScreen displacement binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.65","Kd between VHL and the complex of protac and BCL-xL was assessed by the AlphaScreen displacement binding assay","","","","","","","","","","","15.9/11.3","Inhibit viability of MOLT-4/RS4;11 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00517","1600.47","1598.62530042","13.4","109","10","18","6","33","269.09","C80H102ClF3N10O11S4","InChI=1S/C80H102ClF3N10O11S4/c1-54(56-20-22-58(23-21-56)73-55(2)86-53-107-73)87-76(99)69-46-64(95)50-94(69)77(100)74(78(3,4)5)89-72(97)19-15-10-8-7-9-14-18-71(96)85-52-79(6)36-34-67(57-24-28-61(81)29-25-57)60(48-79)49-92-38-40-93(41-39-92)63-30-26-59(27-31-63)75(98)90-109(103,104)66-32-33-68(70(47-66)108(101,102)80(82,83)84)88-62(35-37-91-42-44-105-45-43-91)51-106-65-16-12-11-13-17-65/h11-13,16-17,20-33,47,53-54,62,64,69,74,88,95H,7-10,14-15,18-19,34-46,48-52H2,1-6H3,(H,85,96)(H,87,99)(H,89,97)(H,90,98)/t54-,62+,64+,69-,74+,79+/m0/s1","CWIUDSZQDVZITQ-QFNMACOTSA-N"
"2391","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.8","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","941.427","940.355222998","4.33","66","8","15","4","16","207.74","C46H54ClN10O8P","InChI=1S/C46H54ClN10O8P/c1-64-37-27-30(11-12-33(37)51-46-49-28-32(47)42(53-46)50-34-8-4-5-10-38(34)66(2,3)63)54-19-15-29(16-20-54)55-21-23-56(24-22-55)40(59)17-25-65-26-18-48-35-9-6-7-31-41(35)45(62)57(44(31)61)36-13-14-39(58)52-43(36)60/h4-12,27-29,36,48H,13-26H2,1-3H3,(H,52,58,60)(H2,49,50,51,53)","ZXYHREHIZXBSGL-UHFFFAOYSA-N"
"2392","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.6","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","985.48","984.381437746","4.18","69","8","16","4","19","216.97","C48H58ClN10O9P","InChI=1S/C48H58ClN10O9P/c1-66-39-29-32(11-12-35(39)53-48-51-30-34(49)44(55-48)52-36-8-4-5-10-40(36)69(2,3)65)56-19-15-31(16-20-56)57-21-23-58(24-22-57)42(61)17-25-67-27-28-68-26-18-50-37-9-6-7-33-43(37)47(64)59(46(33)63)38-13-14-41(60)54-45(38)62/h4-12,29-31,38,50H,13-28H2,1-3H3,(H,54,60,62)(H2,51,52,53,55)","SMUFUCWFRYIBJG-UHFFFAOYSA-N"
"2393","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.3","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","1029.533","1028.40765249","4.03","72","8","17","4","22","226.2","C50H62ClN10O10P","InChI=1S/C50H62ClN10O10P/c1-68-41-31-34(11-12-37(41)55-50-53-32-36(51)46(57-50)54-38-8-4-5-10-42(38)72(2,3)67)58-19-15-33(16-20-58)59-21-23-60(24-22-59)44(63)17-25-69-27-29-71-30-28-70-26-18-52-39-9-6-7-35-45(39)49(66)61(48(35)65)40-13-14-43(62)56-47(40)64/h4-12,31-33,40,52H,13-30H2,1-3H3,(H,56,62,64)(H2,53,54,55,57)","ODMICPNGNYTPPH-UHFFFAOYSA-N"
"2394","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","1073.586","1072.43386724","3.88","75","8","18","4","25","235.43","C52H66ClN10O11P","InChI=1S/C52H66ClN10O11P/c1-70-43-33-36(11-12-39(43)57-52-55-34-38(53)48(59-52)56-40-8-4-5-10-44(40)75(2,3)69)60-19-15-35(16-20-60)61-21-23-62(24-22-61)46(65)17-25-71-27-29-73-31-32-74-30-28-72-26-18-54-41-9-6-7-37-47(41)51(68)63(50(37)67)42-13-14-45(64)58-49(42)66/h4-12,33-35,42,54H,13-32H2,1-3H3,(H,58,64,66)(H2,55,56,57,59)","VNDFCFLSNVJBHP-UHFFFAOYSA-N"
"2395","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","1117.639","1116.46008199","3.74","78","8","19","4","28","244.66","C54H70ClN10O12P","InChI=1S/C54H70ClN10O12P/c1-72-45-35-38(11-12-41(45)59-54-57-36-40(55)50(61-54)58-42-8-4-5-10-46(42)78(2,3)71)62-19-15-37(16-20-62)63-21-23-64(24-22-63)48(67)17-25-73-27-29-75-31-33-77-34-32-76-30-28-74-26-18-56-43-9-6-7-39-49(43)53(70)65(52(39)69)44-13-14-47(66)60-51(44)68/h4-12,35-37,44,56H,13-34H2,1-3H3,(H,60,66,68)(H2,57,58,59,61)","HPOKJFHDBYCCCF-UHFFFAOYSA-N"
"2396","Q05397","FAK","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<1/<1/<1","","Degradation of FAK in NCI-H2228/A549/Calu-1 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","Q9UM73","ALK","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<10","","Degradation of ALK in SR cells after 24 h treatment","","","2.5","IC50 was tested using the KinomeScan platform","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","Q9UM73","ALK G1202R","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<100","","Degradation of ALK G1202R in 293T cells after 72 h treatment","","","6.6","IC50 was tested using the KinomeScan platform","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21","Inhibit proliferation of 293T (ALK G1202R) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","Q14289","PTK2B","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<1","","Degradation of PYK2 in SR cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","Q13882","PTK6","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<1","","Degradation of PTK6 in MDA-MB-231 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","P00533","EGFR L858R/T790M","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<100","","Degradation of EGFR L858R/T790M in H1975 cells after 72 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","42","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","P16591","FER","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<10","","Degradation of FER in SR cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2396","Q15418","RPS6KA1","CRBN","","SIAIS164018","COC1=CC(N2CCC(N3CCN(C(=O)CNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","<100/<100/<100","","Degradation of RSK1 in NCI-H2228/A549/Calu-1 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","883.347","882.313358186","4.57","62","8","14","4","12","198.51","C43H48ClN10O7P","InChI=1S/C43H48ClN10O7P/c1-61-34-23-27(11-12-30(34)48-43-46-24-29(44)39(50-43)47-31-8-4-5-10-35(31)62(2,3)60)51-17-15-26(16-18-51)52-19-21-53(22-20-52)37(56)25-45-32-9-6-7-28-38(32)42(59)54(41(28)58)33-13-14-36(55)49-40(33)57/h4-12,23-24,26,33,45H,13-22,25H2,1-3H3,(H,49,55,57)(H2,46,47,48,50)","AQGLXXCBEXDRNS-UHFFFAOYSA-N"
"2397","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.6","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","897.374","896.32900825","4.47","63","8","14","4","13","198.51","C44H50ClN10O7P","InChI=1S/C44H50ClN10O7P/c1-62-35-25-28(11-12-31(35)49-44-47-26-30(45)40(51-44)48-32-8-4-5-10-36(32)63(2,3)61)52-19-16-27(17-20-52)53-21-23-54(24-22-53)38(57)15-18-46-33-9-6-7-29-39(33)43(60)55(42(29)59)34-13-14-37(56)50-41(34)58/h4-12,25-27,34,46H,13-24H2,1-3H3,(H,50,56,58)(H2,47,48,49,51)","STMDOXCTAANBOG-UHFFFAOYSA-N"
"2398","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.9","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","911.401","910.344658314","4.83","64","8","14","4","14","198.51","C45H52ClN10O7P","InChI=1S/C45H52ClN10O7P/c1-63-36-26-29(13-14-32(36)50-45-48-27-31(46)41(52-45)49-33-9-4-5-11-37(33)64(2,3)62)53-20-17-28(18-21-53)54-22-24-55(25-23-54)39(58)12-7-19-47-34-10-6-8-30-40(34)44(61)56(43(30)60)35-15-16-38(57)51-42(35)59/h4-6,8-11,13-14,26-28,35,47H,7,12,15-25H2,1-3H3,(H,51,57,59)(H2,48,49,50,52)","XGGVMGFIZADQIY-UHFFFAOYSA-N"
"2399","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.4","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","925.428","924.360308378","5.19","65","8","14","4","15","198.51","C46H54ClN10O7P","InChI=1S/C46H54ClN10O7P/c1-64-37-27-30(14-15-33(37)51-46-49-28-32(47)42(53-46)50-34-10-4-5-12-38(34)65(2,3)63)54-21-18-29(19-22-54)55-23-25-56(26-24-55)40(59)13-6-7-20-48-35-11-8-9-31-41(35)45(62)57(44(31)61)36-16-17-39(58)52-43(36)60/h4-5,8-12,14-15,27-29,36,48H,6-7,13,16-26H2,1-3H3,(H,52,58,60)(H2,49,50,51,53)","BSQHFWGPDZFZHA-UHFFFAOYSA-N"
"2400","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.3","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","939.455","938.375958442","5.55","66","8","14","4","16","198.51","C47H56ClN10O7P","InChI=1S/C47H56ClN10O7P/c1-65-38-28-31(15-16-34(38)52-47-50-29-33(48)43(54-47)51-35-11-6-7-13-39(35)66(2,3)64)55-22-19-30(20-23-55)56-24-26-57(27-25-56)41(60)14-5-4-8-21-49-36-12-9-10-32-42(36)46(63)58(45(32)62)37-17-18-40(59)53-44(37)61/h6-7,9-13,15-16,28-30,37,49H,4-5,8,14,17-27H2,1-3H3,(H,53,59,61)(H2,50,51,52,54)","OQNPXBIGAYNXPI-UHFFFAOYSA-N"
"2401","Q9UM73","ALK","CRBN","","","COC1=CC(N2CCC(N3CCN(C(=O)CCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.8","Inhibit proliferation of SR cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00373","953.482","952.391608506","6.09","67","8","14","4","17","198.51","C48H58ClN10O7P","InChI=1S/C48H58ClN10O7P/c1-66-39-29-32(16-17-35(39)53-48-51-30-34(49)44(55-48)52-36-12-7-8-14-40(36)67(2,3)65)56-23-20-31(21-24-56)57-25-27-58(28-26-57)42(61)15-6-4-5-9-22-50-37-13-10-11-33-43(37)47(64)59(46(33)63)38-18-19-41(60)54-45(38)62/h7-8,10-14,16-17,29-31,38,50H,4-6,9,15,18-28H2,1-3H3,(H,54,60,62)(H2,51,52,53,55)","FFQQVUJHMKEQPO-UHFFFAOYSA-N"
"2402","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","186","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","892.349","891.301948616","3.94","64","8","14","4","16","222.74","C44H43ClFN11O7","InChI=1S/C44H43ClFN11O7/c45-30-20-26(12-13-31(30)46)49-41-29-21-34(51-38(59)11-7-18-55-16-3-1-4-17-55)36(22-33(29)47-25-48-41)64-24-27-23-56(54-53-27)19-5-2-10-37(58)50-32-9-6-8-28-40(32)44(63)57(43(28)62)35-14-15-39(60)52-42(35)61/h6-9,11-13,20-23,25,35H,1-5,10,14-19,24H2,(H,50,58)(H,51,59)(H,47,48,49)(H,52,60,61)/b11-7+","NUPNAAWSDJSHQQ-YRNVUSSQSA-N"
"2403","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCCCCCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","46","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","934.43","933.348898808","5.38","67","8","14","4","19","222.74","C47H49ClFN11O7","InChI=1S/C47H49ClFN11O7/c48-33-23-29(15-16-34(33)49)52-44-32-24-37(54-41(62)14-10-21-58-19-6-4-7-20-58)39(25-36(32)50-28-51-44)67-27-30-26-59(57-56-30)22-8-3-1-2-5-13-40(61)53-35-12-9-11-31-43(35)47(66)60(46(31)65)38-17-18-42(63)55-45(38)64/h9-12,14-16,23-26,28,38H,1-8,13,17-22,27H2,(H,53,61)(H,54,62)(H,50,51,52)(H,55,63,64)/b14-10+","IKDWVMHENZHDMZ-GXDHUFHOSA-N"
"2404","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCCCCCCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","948.457","947.364548872","5.92","68","8","14","4","20","222.74","C48H51ClFN11O7","InChI=1S/C48H51ClFN11O7/c49-34-24-30(16-17-35(34)50)53-45-33-25-38(55-42(63)15-11-22-59-20-7-5-8-21-59)40(26-37(33)51-29-52-45)68-28-31-27-60(58-57-31)23-9-4-2-1-3-6-14-41(62)54-36-13-10-12-32-44(36)48(67)61(47(32)66)39-18-19-43(64)56-46(39)65/h10-13,15-17,24-27,29,39H,1-9,14,18-23,28H2,(H,54,62)(H,55,63)(H,51,52,53)(H,56,64,65)/b15-11+","PULWYZNNFMFWCK-RVDMUPIBSA-N"
"2405","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCCCCCCCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","962.484","961.380198936","6.46","69","8","14","4","21","222.74","C49H53ClFN11O7","InChI=1S/C49H53ClFN11O7/c50-35-25-31(17-18-36(35)51)54-46-34-26-39(56-43(64)16-12-23-60-21-8-6-9-22-60)41(27-38(34)52-30-53-46)69-29-32-28-61(59-58-32)24-10-5-3-1-2-4-7-15-42(63)55-37-14-11-13-33-45(37)49(68)62(48(33)67)40-19-20-44(65)57-47(40)66/h11-14,16-18,25-28,30,40H,1-10,15,19-24,29H2,(H,55,63)(H,56,64)(H,52,53,54)(H,57,65,66)/b16-12+","WAIDPWGKISVORF-FOWTUZBSSA-N"
"2406","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCCCCCCCCCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","976.511","975.395849","7.0","70","8","14","4","22","222.74","C50H55ClFN11O7","InChI=1S/C50H55ClFN11O7/c51-36-26-32(18-19-37(36)52)55-47-35-27-40(57-44(65)17-13-24-61-22-9-7-10-23-61)42(28-39(35)53-31-54-47)70-30-33-29-62(60-59-33)25-11-6-4-2-1-3-5-8-16-43(64)56-38-15-12-14-34-46(38)50(69)63(49(34)68)41-20-21-45(66)58-48(41)67/h12-15,17-19,26-29,31,41H,1-11,16,20-25,30H2,(H,56,64)(H,57,65)(H,53,54,55)(H,58,66,67)/b17-13+","QSSBLKJKHHKWHN-GHRIWEEISA-N"
"2407","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCOCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","231","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","938.374","937.30742792","3.02","67","8","16","4","19","241.2","C45H45ClFN11O9","InChI=1S/C45H45ClFN11O9/c46-31-20-27(9-10-32(31)47)50-42-30-21-35(52-38(59)8-5-15-56-13-2-1-3-14-56)37(22-34(30)48-26-49-42)67-24-28-23-57(55-54-28)16-17-65-18-19-66-25-40(61)51-33-7-4-6-29-41(33)45(64)58(44(29)63)36-11-12-39(60)53-43(36)62/h4-10,20-23,26,36H,1-3,11-19,24-25H2,(H,51,61)(H,52,59)(H,48,49,50)(H,53,60,62)/b8-5+","CZGGKPSGPDNZOD-VMPITWQZSA-N"
"2408","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCOCCOCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","278","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","982.427","981.333642668","2.88","70","8","17","4","22","250.43","C47H49ClFN11O10","InChI=1S/C47H49ClFN11O10/c48-33-22-29(9-10-34(33)49)52-44-32-23-37(54-40(61)8-5-15-58-13-2-1-3-14-58)39(24-36(32)50-28-51-44)70-26-30-25-59(57-56-30)16-17-67-18-19-68-20-21-69-27-42(63)53-35-7-4-6-31-43(35)47(66)60(46(31)65)38-11-12-41(62)55-45(38)64/h4-10,22-25,28,38H,1-3,11-21,26-27H2,(H,53,63)(H,54,61)(H,50,51,52)(H,55,62,64)/b8-5+","MDHFKGKNXKSKPN-VMPITWQZSA-N"
"2409","P00533","EGFR e19d","CRBN","","","O=C(/C=C/CN1CCCCC1)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC1=CN(CCOCCOCCOCCOCCOCC(=O)NC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","318","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1070.533","1069.38607216","2.58","76","8","19","4","28","268.89","C51H57ClFN11O12","InChI=1S/C51H57ClFN11O12/c52-37-26-33(9-10-38(37)53)56-48-36-27-41(58-44(65)8-5-15-62-13-2-1-3-14-62)43(28-40(36)54-32-55-48)76-30-34-29-63(61-60-34)16-17-71-18-19-72-20-21-73-22-23-74-24-25-75-31-46(67)57-39-7-4-6-35-47(39)51(70)64(50(35)69)42-11-12-45(66)59-49(42)68/h4-10,26-29,32,42H,1-3,11-25,30-31H2,(H,57,67)(H,58,65)(H,54,55,56)(H,59,66,68)/b8-5+","BPDICUFDYMBUFW-VMPITWQZSA-N"
"2410","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","162","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1049.675","1048.4308546","6.39","74","8","15","5","20","221.72","C53H62ClFN12O6S","InChI=1S/C53H62ClFN12O6S/c1-33-48(74-32-59-33)35-15-13-34(14-16-35)27-56-51(71)44-24-38(68)29-67(44)52(72)49(53(2,3)4)62-47(70)11-6-9-22-66-28-37(63-64-66)30-73-45-26-42-39(50(58-31-57-42)60-36-17-18-41(55)40(54)23-36)25-43(45)61-46(69)12-10-21-65-19-7-5-8-20-65/h10,12-18,23,25-26,28,31-32,38,44,49,68H,5-9,11,19-22,24,27,29-30H2,1-4H3,(H,56,71)(H,61,69)(H,62,70)(H,57,58,60)/b12-10+/t38-,44+,49-/m1/s1","GVYSMKFEIYRGRE-QFYOULDSSA-N"
"2411","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","7.95","98","Degradation of EGFR del19 in HCC-827 cells after 72 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","36","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1091.756","1090.4778048","7.83","77","8","15","5","23","221.72","C56H68ClFN12O6S","InChI=1S/C56H68ClFN12O6S/c1-36-51(77-35-62-36)38-18-16-37(17-19-38)30-59-54(74)47-27-41(71)32-70(47)55(75)52(56(2,3)4)65-50(73)14-9-6-5-7-12-25-69-31-40(66-67-69)33-76-48-29-45-42(53(61-34-60-45)63-39-20-21-44(58)43(57)26-39)28-46(48)64-49(72)15-13-24-68-22-10-8-11-23-68/h13,15-21,26,28-29,31,34-35,41,47,52,71H,5-12,14,22-25,27,30,32-33H2,1-4H3,(H,59,74)(H,64,72)(H,65,73)(H,60,61,63)/b15-13+/t41-,47+,52-/m1/s1","BUDQKNIUFHYJQZ-ABSCMPNGSA-N"
"2412","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1105.783","1104.49345486","8.37","78","8","15","5","24","221.72","C57H70ClFN12O6S","InChI=1S/C57H70ClFN12O6S/c1-37-52(78-36-63-37)39-19-17-38(18-20-39)31-60-55(75)48-28-42(72)33-71(48)56(76)53(57(2,3)4)66-51(74)15-10-7-5-6-8-13-26-70-32-41(67-68-70)34-77-49-30-46-43(54(62-35-61-46)64-40-21-22-45(59)44(58)27-40)29-47(49)65-50(73)16-14-25-69-23-11-9-12-24-69/h14,16-22,27,29-30,32,35-36,42,48,53,72H,5-13,15,23-26,28,31,33-34H2,1-4H3,(H,60,75)(H,65,73)(H,66,74)(H,61,62,64)/b16-14+/t42-,48+,53-/m1/s1","PFGSMDXDMXYRTC-SBVKIVAMSA-N"
"2413","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","29","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1119.81","1118.50910492","8.92","79","8","15","5","25","221.72","C58H72ClFN12O6S","InChI=1S/C58H72ClFN12O6S/c1-38-53(79-37-64-38)40-20-18-39(19-21-40)32-61-56(76)49-29-43(73)34-72(49)57(77)54(58(2,3)4)67-52(75)16-11-8-6-5-7-9-14-27-71-33-42(68-69-71)35-78-50-31-47-44(55(63-36-62-47)65-41-22-23-46(60)45(59)28-41)30-48(50)66-51(74)17-15-26-70-24-12-10-13-25-70/h15,17-23,28,30-31,33,36-37,43,49,54,73H,5-14,16,24-27,29,32,34-35H2,1-4H3,(H,61,76)(H,66,74)(H,67,75)(H,62,63,65)/b17-15+/t43-,49+,54-/m1/s1","CCYWJYVSARIZBI-QRLVMSRCSA-N"
"2414","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","3.57","91","Degradation of EGFR del19 in HCC-827 cells after 72 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1133.837","1132.52475499","9.46","80","8","15","5","26","221.72","C59H74ClFN12O6S","InChI=1S/C59H74ClFN12O6S/c1-39-54(80-38-65-39)41-21-19-40(20-22-41)33-62-57(77)50-30-44(74)35-73(50)58(78)55(59(2,3)4)68-53(76)17-12-9-7-5-6-8-10-15-28-72-34-43(69-70-72)36-79-51-32-48-45(56(64-37-63-48)66-42-23-24-47(61)46(60)29-42)31-49(51)67-52(75)18-16-27-71-25-13-11-14-26-71/h16,18-24,29,31-32,34,37-38,44,50,55,74H,5-15,17,25-28,30,33,35-36H2,1-4H3,(H,62,77)(H,67,75)(H,68,76)(H,63,64,66)/b18-16+/t44-,50+,55-/m1/s1","RBUUUIFZYMVDPT-DLMBMICPSA-N"
"2415","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","200","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1095.7","1094.43633391","5.48","77","8","17","5","23","240.18","C54H64ClFN12O8S","InChI=1S/C54H64ClFN12O8S/c1-34-49(77-33-60-34)36-12-10-35(11-13-36)27-57-52(72)45-24-39(69)29-68(45)53(73)50(54(2,3)4)63-48(71)31-75-22-21-74-20-19-67-28-38(64-65-67)30-76-46-26-43-40(51(59-32-58-43)61-37-14-15-42(56)41(55)23-37)25-44(46)62-47(70)9-8-18-66-16-6-5-7-17-66/h8-15,23,25-26,28,32-33,39,45,50,69H,5-7,16-22,24,27,29-31H2,1-4H3,(H,57,72)(H,62,70)(H,63,71)(H,58,59,61)/b9-8+/t39-,45+,50-/m1/s1","ZBDSGNZFIXZXPY-BAKNNEFNSA-N"
"2416","P00533","EGFR e19d","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","170","Inhibit proliferation of HCC-827 (EGFRdel19) cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2022.105605","1227.859","1226.51497815","5.04","86","8","20","5","32","267.87","C60H76ClFN12O11S","InChI=1S/C60H76ClFN12O11S/c1-40-55(86-39-66-40)42-12-10-41(11-13-42)33-63-58(78)51-30-45(75)35-74(51)59(79)56(60(2,3)4)69-54(77)37-84-28-27-83-26-25-82-24-23-81-22-21-80-20-19-73-34-44(70-71-73)36-85-52-32-49-46(57(65-38-64-49)67-43-14-15-48(62)47(61)29-43)31-50(52)68-53(76)9-8-18-72-16-6-5-7-17-72/h8-15,29,31-32,34,38-39,45,51,56,75H,5-7,16-28,30,33,35-37H2,1-4H3,(H,63,78)(H,68,76)(H,69,77)(H,64,65,67)/b9-8+/t45-,51+,56-/m1/s1","XPPPWNIOTVFKQS-ONKWTBNWSA-N"
"2417","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCN3C=C(COC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","170","Inhibit proliferation of HCC-827 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02221","1139.753","1138.46254866","5.33","80","8","18","5","26","249.41","C56H68ClFN12O9S","InChI=1S/C56H68ClFN12O9S/c1-36-51(80-35-62-36)38-12-10-37(11-13-38)29-59-54(74)47-26-41(71)31-70(47)55(75)52(56(2,3)4)65-50(73)33-78-24-23-77-22-21-76-20-19-69-30-40(66-67-69)32-79-48-28-45-42(53(61-34-60-45)63-39-14-15-44(58)43(57)25-39)27-46(48)64-49(72)9-8-18-68-16-6-5-7-17-68/h8-15,25,27-28,30,34-35,41,47,52,71H,5-7,16-24,26,29,31-33H2,1-4H3,(H,59,74)(H,64,72)(H,65,73)(H,60,61,63)/b9-8+/t41-,47+,52-/m1/s1","VQDITZKUBYFBHD-MUHNYSBJSA-N"
"2418","P00533","EGFR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCN3C=C(CCCCCOC4=CC5=NC=NC(NC6=CC=C(F)C(Cl)=C6)=C5C=C4NC(=O)/C=C/CN4CCCCC4)N=N3)C(C)(C)C)C=C2)SC=N1","36.51","","Degradation of EGFR in HCC-827 cells after 72 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4","Inhibit proliferation of HCC-827 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02221","1151.808","1150.49893416","7.01","81","8","17","5","27","240.18","C58H72ClFN12O8S","InChI=1S/C58H72ClFN12O8S/c1-38-53(81-37-64-38)40-16-14-39(15-17-40)32-61-56(76)49-29-43(73)34-72(49)57(77)54(58(2,3)4)67-52(75)35-79-27-26-78-25-23-71-33-42(68-69-71)12-7-5-10-24-80-50-31-47-44(55(63-36-62-47)65-41-18-19-46(60)45(59)28-41)30-48(50)66-51(74)13-11-22-70-20-8-6-9-21-70/h11,13-19,28,30-31,33,36-37,43,49,54,73H,5-10,12,20-27,29,32,34-35H2,1-4H3,(H,61,76)(H,66,74)(H,67,75)(H,62,63,65)/b13-11+/t43-,49+,54-/m1/s1","PXQHEFZTJMGFAP-QLJGRUAOSA-N"
"2419","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","41","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","810.034","809.39345348","5.54","58","5","9","6","17","195.85","C44H55N7O6S","InChI=1S/C44H55N7O6S/c1-28-39(58-27-47-28)30-18-16-29(17-19-30)25-46-42(56)36-24-33(52)26-51(36)43(57)40(44(2,3)4)50-38(54)15-9-7-5-6-8-14-37(53)48-32-22-20-31(21-23-32)41(55)49-35-13-11-10-12-34(35)45/h10-13,16-23,27,33,36,40,52H,5-9,14-15,24-26,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t33-,36+,40-/m1/s1","XXPSDQVUSUURLT-KTHCSKACSA-N"
"2419","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","32","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","810.034","809.39345348","5.54","58","5","9","6","17","195.85","C44H55N7O6S","InChI=1S/C44H55N7O6S/c1-28-39(58-27-47-28)30-18-16-29(17-19-30)25-46-42(56)36-24-33(52)26-51(36)43(57)40(44(2,3)4)50-38(54)15-9-7-5-6-8-14-37(53)48-32-22-20-31(21-23-32)41(55)49-35-13-11-10-12-34(35)45/h10-13,16-23,27,33,36,40,52H,5-9,14-15,24-26,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t33-,36+,40-/m1/s1","XXPSDQVUSUURLT-KTHCSKACSA-N"
"2419","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","3","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","810.034","809.39345348","5.54","58","5","9","6","17","195.85","C44H55N7O6S","InChI=1S/C44H55N7O6S/c1-28-39(58-27-47-28)30-18-16-29(17-19-30)25-46-42(56)36-24-33(52)26-51(36)43(57)40(44(2,3)4)50-38(54)15-9-7-5-6-8-14-37(53)48-32-22-20-31(21-23-32)41(55)49-35-13-11-10-12-34(35)45/h10-13,16-23,27,33,36,40,52H,5-9,14-15,24-26,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t33-,36+,40-/m1/s1","XXPSDQVUSUURLT-KTHCSKACSA-N"
"2420","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","54","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","824.061","823.409103544","6.08","59","5","9","6","18","195.85","C45H57N7O6S","InChI=1S/C45H57N7O6S/c1-29-40(59-28-48-29)31-19-17-30(18-20-31)26-47-43(57)37-25-34(53)27-52(37)44(58)41(45(2,3)4)51-39(55)16-10-8-6-5-7-9-15-38(54)49-33-23-21-32(22-24-33)42(56)50-36-14-12-11-13-35(36)46/h11-14,17-24,28,34,37,41,53H,5-10,15-16,25-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","UAWAGYHWPQELMG-RDGUTDORSA-N"
"2420","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","37","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","824.061","823.409103544","6.08","59","5","9","6","18","195.85","C45H57N7O6S","InChI=1S/C45H57N7O6S/c1-29-40(59-28-48-29)31-19-17-30(18-20-31)26-47-43(57)37-25-34(53)27-52(37)44(58)41(45(2,3)4)51-39(55)16-10-8-6-5-7-9-15-38(54)49-33-23-21-32(22-24-33)42(56)50-36-14-12-11-13-35(36)46/h11-14,17-24,28,34,37,41,53H,5-10,15-16,25-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","UAWAGYHWPQELMG-RDGUTDORSA-N"
"2420","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","23","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","824.061","823.409103544","6.08","59","5","9","6","18","195.85","C45H57N7O6S","InChI=1S/C45H57N7O6S/c1-29-40(59-28-48-29)31-19-17-30(18-20-31)26-47-43(57)37-25-34(53)27-52(37)44(58)41(45(2,3)4)51-39(55)16-10-8-6-5-7-9-15-38(54)49-33-23-21-32(22-24-33)42(56)50-36-14-12-11-13-35(36)46/h11-14,17-24,28,34,37,41,53H,5-10,15-16,25-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","UAWAGYHWPQELMG-RDGUTDORSA-N"
"2421","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","67","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","838.088","837.424753608","6.63","60","5","9","6","19","195.85","C46H59N7O6S","InChI=1S/C46H59N7O6S/c1-30-41(60-29-49-30)32-20-18-31(19-21-32)27-48-44(58)38-26-35(54)28-53(38)45(59)42(46(2,3)4)52-40(56)17-11-9-7-5-6-8-10-16-39(55)50-34-24-22-33(23-25-34)43(57)51-37-15-13-12-14-36(37)47/h12-15,18-25,29,35,38,42,54H,5-11,16-17,26-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","LNVRDNANRZUWIH-DRTKLYQKSA-N"
"2421","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","43","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","838.088","837.424753608","6.63","60","5","9","6","19","195.85","C46H59N7O6S","InChI=1S/C46H59N7O6S/c1-30-41(60-29-49-30)32-20-18-31(19-21-32)27-48-44(58)38-26-35(54)28-53(38)45(59)42(46(2,3)4)52-40(56)17-11-9-7-5-6-8-10-16-39(55)50-34-24-22-33(23-25-34)43(57)51-37-15-13-12-14-36(37)47/h12-15,18-25,29,35,38,42,54H,5-11,16-17,26-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","LNVRDNANRZUWIH-DRTKLYQKSA-N"
"2421","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","33","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","838.088","837.424753608","6.63","60","5","9","6","19","195.85","C46H59N7O6S","InChI=1S/C46H59N7O6S/c1-30-41(60-29-49-30)32-20-18-31(19-21-32)27-48-44(58)38-26-35(54)28-53(38)45(59)42(46(2,3)4)52-40(56)17-11-9-7-5-6-8-10-16-39(55)50-34-24-22-33(23-25-34)43(57)51-37-15-13-12-14-36(37)47/h12-15,18-25,29,35,38,42,54H,5-11,16-17,26-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","LNVRDNANRZUWIH-DRTKLYQKSA-N"
"2422","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","63","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.169","879.4717038","8.25","63","5","9","6","22","195.85","C49H65N7O6S","InChI=1S/C49H65N7O6S/c1-33-44(63-32-52-33)35-23-21-34(22-24-35)30-51-47(61)41-29-38(57)31-56(41)48(62)45(49(2,3)4)55-43(59)20-14-12-10-8-6-5-7-9-11-13-19-42(58)53-37-27-25-36(26-28-37)46(60)54-40-18-16-15-17-39(40)50/h15-18,21-28,32,38,41,45,57H,5-14,19-20,29-31,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t38-,41+,45-/m1/s1","AHURBROGQUEMLW-XVYMMXEDSA-N"
"2422","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","44","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.169","879.4717038","8.25","63","5","9","6","22","195.85","C49H65N7O6S","InChI=1S/C49H65N7O6S/c1-33-44(63-32-52-33)35-23-21-34(22-24-35)30-51-47(61)41-29-38(57)31-56(41)48(62)45(49(2,3)4)55-43(59)20-14-12-10-8-6-5-7-9-11-13-19-42(58)53-37-27-25-36(26-28-37)46(60)54-40-18-16-15-17-39(40)50/h15-18,21-28,32,38,41,45,57H,5-14,19-20,29-31,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t38-,41+,45-/m1/s1","AHURBROGQUEMLW-XVYMMXEDSA-N"
"2422","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","44","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.169","879.4717038","8.25","63","5","9","6","22","195.85","C49H65N7O6S","InChI=1S/C49H65N7O6S/c1-33-44(63-32-52-33)35-23-21-34(22-24-35)30-51-47(61)41-29-38(57)31-56(41)48(62)45(49(2,3)4)55-43(59)20-14-12-10-8-6-5-7-9-11-13-19-42(58)53-37-27-25-36(26-28-37)46(60)54-40-18-16-15-17-39(40)50/h15-18,21-28,32,38,41,45,57H,5-14,19-20,29-31,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t38-,41+,45-/m1/s1","AHURBROGQUEMLW-XVYMMXEDSA-N"
"2423","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","60","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-40(56)28-60-24-12-8-6-5-7-9-15-39(55)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","GNWRYRVABIRHOP-DRTKLYQKSA-N"
"2423","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","57","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-40(56)28-60-24-12-8-6-5-7-9-15-39(55)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","GNWRYRVABIRHOP-DRTKLYQKSA-N"
"2423","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","67","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-40(56)28-60-24-12-8-6-5-7-9-15-39(55)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,55)(H,51,57)(H,52,56)/t35-,38+,42-/m1/s1","GNWRYRVABIRHOP-DRTKLYQKSA-N"
"2424","O15379","HDAC3","VHL","","JPS014","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","640","59","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","140","IC50 of HDAC3-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-39(55)15-9-7-5-6-8-12-24-60-28-40(56)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,56)(H,51,57)(H,52,55)/t35-,38+,42-/m1/s1","QANLZMZKZIPVPD-DRTKLYQKSA-N"
"2424","Q13547","HDAC1","VHL","","JPS014","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","910","74","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","220","IC50 of HDAC1-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-39(55)15-9-7-5-6-8-12-24-60-28-40(56)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,56)(H,51,57)(H,52,55)/t35-,38+,42-/m1/s1","QANLZMZKZIPVPD-DRTKLYQKSA-N"
"2424","Q92769","HDAC2","VHL","","JPS014","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","4190","56","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","360","IC50 of HDAC2-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","854.087","853.419668228","5.85","61","5","10","6","20","205.08","C46H59N7O7S","InChI=1S/C46H59N7O7S/c1-30-41(61-29-49-30)32-18-16-31(17-19-32)26-48-44(58)38-25-35(54)27-53(38)45(59)42(46(2,3)4)52-39(55)15-9-7-5-6-8-12-24-60-28-40(56)50-34-22-20-33(21-23-34)43(57)51-37-14-11-10-13-36(37)47/h10-11,13-14,16-23,29,35,38,42,54H,5-9,12,15,24-28,47H2,1-4H3,(H,48,58)(H,50,56)(H,51,57)(H,52,55)/t35-,38+,42-/m1/s1","QANLZMZKZIPVPD-DRTKLYQKSA-N"
"2425","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","57","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","856.059","855.398932784","4.53","61","5","11","6","20","214.31","C45H57N7O8S","InChI=1S/C45H57N7O8S/c1-29-40(61-28-48-29)31-15-13-30(14-16-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-60-22-10-6-5-9-21-59-26-38(54)49-33-19-17-32(18-20-33)42(56)50-36-12-8-7-11-35(36)46/h7-8,11-20,28,34,37,41,53H,5-6,9-10,21-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","XBGNSTADRHNHPM-RDGUTDORSA-N"
"2425","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","47","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","856.059","855.398932784","4.53","61","5","11","6","20","214.31","C45H57N7O8S","InChI=1S/C45H57N7O8S/c1-29-40(61-28-48-29)31-15-13-30(14-16-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-60-22-10-6-5-9-21-59-26-38(54)49-33-19-17-32(18-20-33)42(56)50-36-12-8-7-11-35(36)46/h7-8,11-20,28,34,37,41,53H,5-6,9-10,21-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","XBGNSTADRHNHPM-RDGUTDORSA-N"
"2425","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","39","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","856.059","855.398932784","4.53","61","5","11","6","20","214.31","C45H57N7O8S","InChI=1S/C45H57N7O8S/c1-29-40(61-28-48-29)31-15-13-30(14-16-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-60-22-10-6-5-9-21-59-26-38(54)49-33-19-17-32(18-20-33)42(56)50-36-12-8-7-11-35(36)46/h7-8,11-20,28,34,37,41,53H,5-6,9-10,21-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","XBGNSTADRHNHPM-RDGUTDORSA-N"
"2426","O15379","HDAC3","VHL","","JPS016","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","530","66","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","380","IC50 of HDAC3-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","898.14","897.445882976","6.16","64","5","11","6","23","214.31","C48H63N7O8S","InChI=1S/C48H63N7O8S/c1-32-43(64-31-51-32)34-18-16-33(17-19-34)27-50-46(60)40-26-37(56)28-55(40)47(61)44(48(2,3)4)54-42(58)30-63-25-13-9-7-5-6-8-12-24-62-29-41(57)52-36-22-20-35(21-23-36)45(59)53-39-15-11-10-14-38(39)49/h10-11,14-23,31,37,40,44,56H,5-9,12-13,24-30,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t37-,40+,44-/m1/s1","BOXZMOCGSKLDAH-OUZJXKGJSA-N"
"2426","Q13547","HDAC1","VHL","","JPS016","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","550","77","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","570","IC50 of HDAC1-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","898.14","897.445882976","6.16","64","5","11","6","23","214.31","C48H63N7O8S","InChI=1S/C48H63N7O8S/c1-32-43(64-31-51-32)34-18-16-33(17-19-34)27-50-46(60)40-26-37(56)28-55(40)47(61)44(48(2,3)4)54-42(58)30-63-25-13-9-7-5-6-8-12-24-62-29-41(57)52-36-22-20-35(21-23-36)45(59)53-39-15-11-10-14-38(39)49/h10-11,14-23,31,37,40,44,56H,5-9,12-13,24-30,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t37-,40+,44-/m1/s1","BOXZMOCGSKLDAH-OUZJXKGJSA-N"
"2426","Q92769","HDAC2","VHL","","JPS016","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","52","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","820","IC50 of HDAC2-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","898.14","897.445882976","6.16","64","5","11","6","23","214.31","C48H63N7O8S","InChI=1S/C48H63N7O8S/c1-32-43(64-31-51-32)34-18-16-33(17-19-34)27-50-46(60)40-26-37(56)28-55(40)47(61)44(48(2,3)4)54-42(58)30-63-25-13-9-7-5-6-8-12-24-62-29-41(57)52-36-22-20-35(21-23-36)45(59)53-39-15-11-10-14-38(39)49/h10-11,14-23,31,37,40,44,56H,5-9,12-13,24-30,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t37-,40+,44-/m1/s1","BOXZMOCGSKLDAH-OUZJXKGJSA-N"
"2427","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","13","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","799.951","799.336332528","3.1","57","5","11","6","16","214.31","C41H49N7O8S","InChI=1S/C41H49N7O8S/c1-25-36(57-24-44-25)27-11-9-26(10-12-27)20-43-39(53)33-19-30(49)21-48(33)40(54)37(41(2,3)4)47-35(51)23-56-18-17-55-22-34(50)45-29-15-13-28(14-16-29)38(52)46-32-8-6-5-7-31(32)42/h5-16,24,30,33,37,49H,17-23,42H2,1-4H3,(H,43,53)(H,45,50)(H,46,52)(H,47,51)/t30-,33+,37-/m1/s1","LDFNYUSMNVVOAO-FHRXIHKVSA-N"
"2427","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","6","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","799.951","799.336332528","3.1","57","5","11","6","16","214.31","C41H49N7O8S","InChI=1S/C41H49N7O8S/c1-25-36(57-24-44-25)27-11-9-26(10-12-27)20-43-39(53)33-19-30(49)21-48(33)40(54)37(41(2,3)4)47-35(51)23-56-18-17-55-22-34(50)45-29-15-13-28(14-16-29)38(52)46-32-8-6-5-7-31(32)42/h5-16,24,30,33,37,49H,17-23,42H2,1-4H3,(H,43,53)(H,45,50)(H,46,52)(H,47,51)/t30-,33+,37-/m1/s1","LDFNYUSMNVVOAO-FHRXIHKVSA-N"
"2427","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","24","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","799.951","799.336332528","3.1","57","5","11","6","16","214.31","C41H49N7O8S","InChI=1S/C41H49N7O8S/c1-25-36(57-24-44-25)27-11-9-26(10-12-27)20-43-39(53)33-19-30(49)21-48(33)40(54)37(41(2,3)4)47-35(51)23-56-18-17-55-22-34(50)45-29-15-13-28(14-16-29)38(52)46-32-8-6-5-7-31(32)42/h5-16,24,30,33,37,49H,17-23,42H2,1-4H3,(H,43,53)(H,45,50)(H,46,52)(H,47,51)/t30-,33+,37-/m1/s1","LDFNYUSMNVVOAO-FHRXIHKVSA-N"
"2428","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","29","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","844.004","843.362547276","2.96","60","5","12","6","19","223.54","C43H53N7O9S","InChI=1S/C43H53N7O9S/c1-27-38(60-26-46-27)29-11-9-28(10-12-29)22-45-41(55)35-21-32(51)23-50(35)42(56)39(43(2,3)4)49-37(53)25-59-20-18-57-17-19-58-24-36(52)47-31-15-13-30(14-16-31)40(54)48-34-8-6-5-7-33(34)44/h5-16,26,32,35,39,51H,17-25,44H2,1-4H3,(H,45,55)(H,47,52)(H,48,54)(H,49,53)/t32-,35+,39-/m1/s1","MNUQUYIPHCWRAK-MNYREFGISA-N"
"2428","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","14","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","844.004","843.362547276","2.96","60","5","12","6","19","223.54","C43H53N7O9S","InChI=1S/C43H53N7O9S/c1-27-38(60-26-46-27)29-11-9-28(10-12-29)22-45-41(55)35-21-32(51)23-50(35)42(56)39(43(2,3)4)49-37(53)25-59-20-18-57-17-19-58-24-36(52)47-31-15-13-30(14-16-31)40(54)48-34-8-6-5-7-33(34)44/h5-16,26,32,35,39,51H,17-25,44H2,1-4H3,(H,45,55)(H,47,52)(H,48,54)(H,49,53)/t32-,35+,39-/m1/s1","MNUQUYIPHCWRAK-MNYREFGISA-N"
"2428","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","44","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","844.004","843.362547276","2.96","60","5","12","6","19","223.54","C43H53N7O9S","InChI=1S/C43H53N7O9S/c1-27-38(60-26-46-27)29-11-9-28(10-12-29)22-45-41(55)35-21-32(51)23-50(35)42(56)39(43(2,3)4)49-37(53)25-59-20-18-57-17-19-58-24-36(52)47-31-15-13-30(14-16-31)40(54)48-34-8-6-5-7-33(34)44/h5-16,26,32,35,39,51H,17-25,44H2,1-4H3,(H,45,55)(H,47,52)(H,48,54)(H,49,53)/t32-,35+,39-/m1/s1","MNUQUYIPHCWRAK-MNYREFGISA-N"
"2429","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","6","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","888.057","887.388762024","2.81","63","5","13","6","22","232.77","C45H57N7O10S","InChI=1S/C45H57N7O10S/c1-29-40(63-28-48-29)31-11-9-30(10-12-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-62-22-20-60-18-17-59-19-21-61-26-38(54)49-33-15-13-32(14-16-33)42(56)50-36-8-6-5-7-35(36)46/h5-16,28,34,37,41,53H,17-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","CJLCITMDOZXVCN-RDGUTDORSA-N"
"2429","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","5","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","888.057","887.388762024","2.81","63","5","13","6","22","232.77","C45H57N7O10S","InChI=1S/C45H57N7O10S/c1-29-40(63-28-48-29)31-11-9-30(10-12-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-62-22-20-60-18-17-59-19-21-61-26-38(54)49-33-15-13-32(14-16-33)42(56)50-36-8-6-5-7-35(36)46/h5-16,28,34,37,41,53H,17-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","CJLCITMDOZXVCN-RDGUTDORSA-N"
"2429","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","22","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","888.057","887.388762024","2.81","63","5","13","6","22","232.77","C45H57N7O10S","InChI=1S/C45H57N7O10S/c1-29-40(63-28-48-29)31-11-9-30(10-12-31)24-47-43(57)37-23-34(53)25-52(37)44(58)41(45(2,3)4)51-39(55)27-62-22-20-60-18-17-59-19-21-61-26-38(54)49-33-15-13-32(14-16-33)42(56)50-36-8-6-5-7-35(36)46/h5-16,28,34,37,41,53H,17-27,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t34-,37+,41-/m1/s1","CJLCITMDOZXVCN-RDGUTDORSA-N"
"2430","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCN3CCN(CCCC(=O)NC4=CC=C(C(=O)NC5=CC=CC=C5N)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","4","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.129","879.446551672","3.77","63","6","11","6","17","202.33","C47H61N9O6S","InChI=1S/C47H61N9O6S/c1-31-42(63-30-50-31)33-15-13-32(14-16-33)28-49-45(61)39-27-36(57)29-56(39)46(62)43(47(2,3)4)53-41(59)12-8-22-55-25-23-54(24-26-55)21-7-11-40(58)51-35-19-17-34(18-20-35)44(60)52-38-10-6-5-9-37(38)48/h5-6,9-10,13-20,30,36,39,43,57H,7-8,11-12,21-29,48H2,1-4H3,(H,49,61)(H,51,58)(H,52,60)(H,53,59)/t36-,39+,43-/m1/s1","BTSROZKIJVUHNO-IPQHXDNUSA-N"
"2430","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCN3CCN(CCCC(=O)NC4=CC=C(C(=O)NC5=CC=CC=C5N)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","5","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.129","879.446551672","3.77","63","6","11","6","17","202.33","C47H61N9O6S","InChI=1S/C47H61N9O6S/c1-31-42(63-30-50-31)33-15-13-32(14-16-33)28-49-45(61)39-27-36(57)29-56(39)46(62)43(47(2,3)4)53-41(59)12-8-22-55-25-23-54(24-26-55)21-7-11-40(58)51-35-19-17-34(18-20-35)44(60)52-38-10-6-5-9-37(38)48/h5-6,9-10,13-20,30,36,39,43,57H,7-8,11-12,21-29,48H2,1-4H3,(H,49,61)(H,51,58)(H,52,60)(H,53,59)/t36-,39+,43-/m1/s1","BTSROZKIJVUHNO-IPQHXDNUSA-N"
"2430","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCN3CCN(CCCC(=O)NC4=CC=C(C(=O)NC5=CC=CC=C5N)C=C4)CC3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","880.129","879.446551672","3.77","63","6","11","6","17","202.33","C47H61N9O6S","InChI=1S/C47H61N9O6S/c1-31-42(63-30-50-31)33-15-13-32(14-16-33)28-49-45(61)39-27-36(57)29-56(39)46(62)43(47(2,3)4)53-41(59)12-8-22-55-25-23-54(24-26-55)21-7-11-40(58)51-35-19-17-34(18-20-35)44(60)52-38-10-6-5-9-37(38)48/h5-6,9-10,13-20,30,36,39,43,57H,7-8,11-12,21-29,48H2,1-4H3,(H,49,61)(H,51,58)(H,52,60)(H,53,59)/t36-,39+,43-/m1/s1","BTSROZKIJVUHNO-IPQHXDNUSA-N"
"2431","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","41","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","828.024","827.384031668","5.64","59","5","9","6","17","195.85","C44H54FN7O6S","InChI=1S/C44H54FN7O6S/c1-27-39(59-26-48-27)29-14-12-28(13-15-29)24-47-42(57)36-23-33(53)25-52(36)43(58)40(44(2,3)4)51-38(55)11-9-7-5-6-8-10-37(54)49-32-19-16-30(17-20-32)41(56)50-35-21-18-31(45)22-34(35)46/h12-22,26,33,36,40,53H,5-11,23-25,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t33-,36+,40-/m1/s1","ZMQIQFPWRGOCBN-KTHCSKACSA-N"
"2431","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","13","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","828.024","827.384031668","5.64","59","5","9","6","17","195.85","C44H54FN7O6S","InChI=1S/C44H54FN7O6S/c1-27-39(59-26-48-27)29-14-12-28(13-15-29)24-47-42(57)36-23-33(53)25-52(36)43(58)40(44(2,3)4)51-38(55)11-9-7-5-6-8-10-37(54)49-32-19-16-30(17-20-32)41(56)50-35-21-18-31(45)22-34(35)46/h12-22,26,33,36,40,53H,5-11,23-25,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t33-,36+,40-/m1/s1","ZMQIQFPWRGOCBN-KTHCSKACSA-N"
"2431","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","39","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","828.024","827.384031668","5.64","59","5","9","6","17","195.85","C44H54FN7O6S","InChI=1S/C44H54FN7O6S/c1-27-39(59-26-48-27)29-14-12-28(13-15-29)24-47-42(57)36-23-33(53)25-52(36)43(58)40(44(2,3)4)51-38(55)11-9-7-5-6-8-10-37(54)49-32-19-16-30(17-20-32)41(56)50-35-21-18-31(45)22-34(35)46/h12-22,26,33,36,40,53H,5-11,23-25,46H2,1-4H3,(H,47,57)(H,49,54)(H,50,56)(H,51,55)/t33-,36+,40-/m1/s1","ZMQIQFPWRGOCBN-KTHCSKACSA-N"
"2432","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","61","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","870.105","869.43098186","7.27","62","5","9","6","20","195.85","C47H60FN7O6S","InChI=1S/C47H60FN7O6S/c1-30-42(62-29-51-30)32-17-15-31(16-18-32)27-50-45(60)39-26-36(56)28-55(39)46(61)43(47(2,3)4)54-41(58)14-12-10-8-6-5-7-9-11-13-40(57)52-35-22-19-33(20-23-35)44(59)53-38-24-21-34(48)25-37(38)49/h15-25,29,36,39,43,56H,5-14,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,43-/m1/s1","NEDMKPKINQQVSY-IPQHXDNUSA-N"
"2432","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","26","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","870.105","869.43098186","7.27","62","5","9","6","20","195.85","C47H60FN7O6S","InChI=1S/C47H60FN7O6S/c1-30-42(62-29-51-30)32-17-15-31(16-18-32)27-50-45(60)39-26-36(56)28-55(39)46(61)43(47(2,3)4)54-41(58)14-12-10-8-6-5-7-9-11-13-40(57)52-35-22-19-33(20-23-35)44(59)53-38-24-21-34(48)25-37(38)49/h15-25,29,36,39,43,56H,5-14,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,43-/m1/s1","NEDMKPKINQQVSY-IPQHXDNUSA-N"
"2432","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","51","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","870.105","869.43098186","7.27","62","5","9","6","20","195.85","C47H60FN7O6S","InChI=1S/C47H60FN7O6S/c1-30-42(62-29-51-30)32-17-15-31(16-18-32)27-50-45(60)39-26-36(56)28-55(39)46(61)43(47(2,3)4)54-41(58)14-12-10-8-6-5-7-9-11-13-40(57)52-35-22-19-33(20-23-35)44(59)53-38-24-21-34(48)25-37(38)49/h15-25,29,36,39,43,56H,5-14,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,43-/m1/s1","NEDMKPKINQQVSY-IPQHXDNUSA-N"
"2433","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","11","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","861.994","861.353125464","3.06","61","5","12","6","19","223.54","C43H52FN7O9S","InChI=1S/C43H52FN7O9S/c1-26-38(61-25-47-26)28-7-5-27(6-8-28)21-46-41(56)35-20-32(52)22-51(35)42(57)39(43(2,3)4)50-37(54)24-60-18-16-58-15-17-59-23-36(53)48-31-12-9-29(10-13-31)40(55)49-34-14-11-30(44)19-33(34)45/h5-14,19,25,32,35,39,52H,15-18,20-24,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t32-,35+,39-/m1/s1","PZHPXXZQHPOAGY-MNYREFGISA-N"
"2433","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","861.994","861.353125464","3.06","61","5","12","6","19","223.54","C43H52FN7O9S","InChI=1S/C43H52FN7O9S/c1-26-38(61-25-47-26)28-7-5-27(6-8-28)21-46-41(56)35-20-32(52)22-51(35)42(57)39(43(2,3)4)50-37(54)24-60-18-16-58-15-17-59-23-36(53)48-31-12-9-29(10-13-31)40(55)49-34-14-11-30(44)19-33(34)45/h5-14,19,25,32,35,39,52H,15-18,20-24,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t32-,35+,39-/m1/s1","PZHPXXZQHPOAGY-MNYREFGISA-N"
"2433","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","37","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","861.994","861.353125464","3.06","61","5","12","6","19","223.54","C43H52FN7O9S","InChI=1S/C43H52FN7O9S/c1-26-38(61-25-47-26)28-7-5-27(6-8-28)21-46-41(56)35-20-32(52)22-51(35)42(57)39(43(2,3)4)50-37(54)24-60-18-16-58-15-17-59-23-36(53)48-31-12-9-29(10-13-31)40(55)49-34-14-11-30(44)19-33(34)45/h5-14,19,25,32,35,39,52H,15-18,20-24,45H2,1-4H3,(H,46,56)(H,48,53)(H,49,55)(H,50,54)/t32-,35+,39-/m1/s1","PZHPXXZQHPOAGY-MNYREFGISA-N"
"2434","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","58","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","916.13","915.436461164","6.26","65","5","11","6","23","214.31","C48H62FN7O8S","InChI=1S/C48H62FN7O8S/c1-31-43(65-30-52-31)33-14-12-32(13-15-33)26-51-46(61)40-25-37(57)27-56(40)47(62)44(48(2,3)4)55-42(59)29-64-23-11-9-7-5-6-8-10-22-63-28-41(58)53-36-19-16-34(17-20-36)45(60)54-39-21-18-35(49)24-38(39)50/h12-21,24,30,37,40,44,57H,5-11,22-23,25-29,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t37-,40+,44-/m1/s1","AGMBKWPLZPKEGR-OUZJXKGJSA-N"
"2434","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","23","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","916.13","915.436461164","6.26","65","5","11","6","23","214.31","C48H62FN7O8S","InChI=1S/C48H62FN7O8S/c1-31-43(65-30-52-31)33-14-12-32(13-15-33)26-51-46(61)40-25-37(57)27-56(40)47(62)44(48(2,3)4)55-42(59)29-64-23-11-9-7-5-6-8-10-22-63-28-41(58)53-36-19-16-34(17-20-36)45(60)54-39-21-18-35(49)24-38(39)50/h12-21,24,30,37,40,44,57H,5-11,22-23,25-29,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t37-,40+,44-/m1/s1","AGMBKWPLZPKEGR-OUZJXKGJSA-N"
"2434","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)NC3=CC=C(C(=O)NC4=CC=C(F)C=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","63","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","916.13","915.436461164","6.26","65","5","11","6","23","214.31","C48H62FN7O8S","InChI=1S/C48H62FN7O8S/c1-31-43(65-30-52-31)33-14-12-32(13-15-33)26-51-46(61)40-25-37(57)27-56(40)47(62)44(48(2,3)4)55-42(59)29-64-23-11-9-7-5-6-8-10-22-63-28-41(58)53-36-19-16-34(17-20-36)45(60)54-39-21-18-35(49)24-38(39)50/h12-21,24,30,37,40,44,57H,5-11,22-23,25-29,50H2,1-4H3,(H,51,61)(H,53,58)(H,54,60)(H,55,59)/t37-,40+,44-/m1/s1","AGMBKWPLZPKEGR-OUZJXKGJSA-N"
"2435","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","6","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","892.161","891.381174544","6.89","63","6","10","6","18","195.85","C48H57N7O6S2","InChI=1S/C48H57N7O6S2/c1-30-43(63-29-51-30)32-16-14-31(15-17-32)27-50-46(60)39-26-36(56)28-55(39)47(61)44(48(2,3)4)54-42(58)13-9-7-5-6-8-12-41(57)52-35-21-18-33(19-22-35)45(59)53-38-25-34(20-23-37(38)49)40-11-10-24-62-40/h10-11,14-25,29,36,39,44,56H,5-9,12-13,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,44-/m1/s1","SLSLECNMOKDWNA-INMVVMDYSA-N"
"2435","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","6","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","892.161","891.381174544","6.89","63","6","10","6","18","195.85","C48H57N7O6S2","InChI=1S/C48H57N7O6S2/c1-30-43(63-29-51-30)32-16-14-31(15-17-32)27-50-46(60)39-26-36(56)28-55(39)47(61)44(48(2,3)4)54-42(58)13-9-7-5-6-8-12-41(57)52-35-21-18-33(19-22-35)45(59)53-38-25-34(20-23-37(38)49)40-11-10-24-62-40/h10-11,14-25,29,36,39,44,56H,5-9,12-13,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,44-/m1/s1","SLSLECNMOKDWNA-INMVVMDYSA-N"
"2435","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","3","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","892.161","891.381174544","6.89","63","6","10","6","18","195.85","C48H57N7O6S2","InChI=1S/C48H57N7O6S2/c1-30-43(63-29-51-30)32-16-14-31(15-17-32)27-50-46(60)39-26-36(56)28-55(39)47(61)44(48(2,3)4)54-42(58)13-9-7-5-6-8-12-41(57)52-35-21-18-33(19-22-35)45(59)53-38-25-34(20-23-37(38)49)40-11-10-24-62-40/h10-11,14-25,29,36,39,44,56H,5-9,12-13,26-28,49H2,1-4H3,(H,50,60)(H,52,57)(H,53,59)(H,54,58)/t36-,39+,44-/m1/s1","SLSLECNMOKDWNA-INMVVMDYSA-N"
"2436","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","26","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","934.242","933.428124736","8.51","66","6","10","6","21","195.85","C51H63N7O6S2","InChI=1S/C51H63N7O6S2/c1-33-46(66-32-54-33)35-19-17-34(18-20-35)30-53-49(63)42-29-39(59)31-58(42)50(64)47(51(2,3)4)57-45(61)16-12-10-8-6-5-7-9-11-15-44(60)55-38-24-21-36(22-25-38)48(62)56-41-28-37(23-26-40(41)52)43-14-13-27-65-43/h13-14,17-28,32,39,42,47,59H,5-12,15-16,29-31,52H2,1-4H3,(H,53,63)(H,55,60)(H,56,62)(H,57,61)/t39-,42+,47-/m1/s1","PYFJRWPCHWNACA-PDZNDIJHSA-N"
"2436","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","15","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","934.242","933.428124736","8.51","66","6","10","6","21","195.85","C51H63N7O6S2","InChI=1S/C51H63N7O6S2/c1-33-46(66-32-54-33)35-19-17-34(18-20-35)30-53-49(63)42-29-39(59)31-58(42)50(64)47(51(2,3)4)57-45(61)16-12-10-8-6-5-7-9-11-15-44(60)55-38-24-21-36(22-25-38)48(62)56-41-28-37(23-26-40(41)52)43-14-13-27-65-43/h13-14,17-28,32,39,42,47,59H,5-12,15-16,29-31,52H2,1-4H3,(H,53,63)(H,55,60)(H,56,62)(H,57,61)/t39-,42+,47-/m1/s1","PYFJRWPCHWNACA-PDZNDIJHSA-N"
"2436","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","10","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","934.242","933.428124736","8.51","66","6","10","6","21","195.85","C51H63N7O6S2","InChI=1S/C51H63N7O6S2/c1-33-46(66-32-54-33)35-19-17-34(18-20-35)30-53-49(63)42-29-39(59)31-58(42)50(64)47(51(2,3)4)57-45(61)16-12-10-8-6-5-7-9-11-15-44(60)55-38-24-21-36(22-25-38)48(62)56-41-28-37(23-26-40(41)52)43-14-13-27-65-43/h13-14,17-28,32,39,42,47,59H,5-12,15-16,29-31,52H2,1-4H3,(H,53,63)(H,55,60)(H,56,62)(H,57,61)/t39-,42+,47-/m1/s1","PYFJRWPCHWNACA-PDZNDIJHSA-N"
"2437","Q13547","HDAC1","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","22","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","926.131","925.35026834","4.3","65","6","13","6","20","223.54","C47H55N7O9S2","InChI=1S/C47H55N7O9S2/c1-29-42(65-28-50-29)31-9-7-30(8-10-31)24-49-45(59)38-23-35(55)25-54(38)46(60)43(47(2,3)4)53-41(57)27-63-20-18-61-17-19-62-26-40(56)51-34-14-11-32(12-15-34)44(58)52-37-22-33(13-16-36(37)48)39-6-5-21-64-39/h5-16,21-22,28,35,38,43,55H,17-20,23-27,48H2,1-4H3,(H,49,59)(H,51,56)(H,52,58)(H,53,57)/t35-,38+,43-/m1/s1","DMWWBSQOUPHWCN-YUCKTDLNSA-N"
"2437","Q92769","HDAC2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","15","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","926.131","925.35026834","4.3","65","6","13","6","20","223.54","C47H55N7O9S2","InChI=1S/C47H55N7O9S2/c1-29-42(65-28-50-29)31-9-7-30(8-10-31)24-49-45(59)38-23-35(55)25-54(38)46(60)43(47(2,3)4)53-41(57)27-63-20-18-61-17-19-62-26-40(56)51-34-14-11-32(12-15-34)44(58)52-37-22-33(13-16-36(37)48)39-6-5-21-64-39/h5-16,21-22,28,35,38,43,55H,17-20,23-27,48H2,1-4H3,(H,49,59)(H,51,56)(H,52,58)(H,53,57)/t35-,38+,43-/m1/s1","DMWWBSQOUPHWCN-YUCKTDLNSA-N"
"2437","O15379","HDAC3","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCOCCOCC(=O)NC3=CC=C(C(=O)NC4=CC(C5=CC=CS5)=CC=C4N)C=C3)C(C)(C)C)C=C2)SC=N1","","23","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","926.131","925.35026834","4.3","65","6","13","6","20","223.54","C47H55N7O9S2","InChI=1S/C47H55N7O9S2/c1-29-42(65-28-50-29)31-9-7-30(8-10-31)24-49-45(59)38-23-35(55)25-54(38)46(60)43(47(2,3)4)53-41(57)27-63-20-18-61-17-19-62-26-40(56)51-34-14-11-32(12-15-34)44(58)52-37-22-33(13-16-36(37)48)39-6-5-21-64-39/h5-16,21-22,28,35,38,43,55H,17-20,23-27,48H2,1-4H3,(H,49,59)(H,51,56)(H,52,58)(H,53,57)/t35-,38+,43-/m1/s1","DMWWBSQOUPHWCN-YUCKTDLNSA-N"
"2438","O15379","HDAC3","VHL","","JPS035","CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCCCCCCCCCCC(=O)NC1=CC=C(C(=O)NC2=CC=CC=C2N)C=C1)C(C)(C)C","1380","76","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","3810","IC50 of HDAC3-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","896.168","895.46661842","7.56","64","5","10","6","22","205.08","C49H65N7O7S","InChI=1S/C49H65N7O7S/c1-32-44(64-31-52-32)35-20-21-36(29-51-47(61)41-28-38(58)30-56(41)48(62)45(49(3,4)5)53-33(2)57)42(27-35)63-26-16-12-10-8-6-7-9-11-13-19-43(59)54-37-24-22-34(23-25-37)46(60)55-40-18-15-14-17-39(40)50/h14-15,17-18,20-25,27,31,38,41,45,58H,6-13,16,19,26,28-30,50H2,1-5H3,(H,51,61)(H,53,57)(H,54,59)(H,55,60)/t38-,41+,45-/m1/s1","XPJGKIYHVFVWKJ-XVYMMXEDSA-N"
"2438","Q13547","HDAC1","VHL","","JPS035","CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCCCCCCCCCCC(=O)NC1=CC=C(C(=O)NC2=CC=CC=C2N)C=C1)C(C)(C)C","3580","68","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","1810","IC50 of HDAC1-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","896.168","895.46661842","7.56","64","5","10","6","22","205.08","C49H65N7O7S","InChI=1S/C49H65N7O7S/c1-32-44(64-31-52-32)35-20-21-36(29-51-47(61)41-28-38(58)30-56(41)48(62)45(49(3,4)5)53-33(2)57)42(27-35)63-26-16-12-10-8-6-7-9-11-13-19-43(59)54-37-24-22-34(23-25-37)46(60)55-40-18-15-14-17-39(40)50/h14-15,17-18,20-25,27,31,38,41,45,58H,6-13,16,19,26,28-30,50H2,1-5H3,(H,51,61)(H,53,57)(H,54,59)(H,55,60)/t38-,41+,45-/m1/s1","XPJGKIYHVFVWKJ-XVYMMXEDSA-N"
"2438","Q92769","HDAC2","VHL","","JPS035","CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCCCCCCCCCCC(=O)NC1=CC=C(C(=O)NC2=CC=CC=C2N)C=C1)C(C)(C)C","","50","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","3460","IC50 of HDAC2-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","896.168","895.46661842","7.56","64","5","10","6","22","205.08","C49H65N7O7S","InChI=1S/C49H65N7O7S/c1-32-44(64-31-52-32)35-20-21-36(29-51-47(61)41-28-38(58)30-56(41)48(62)45(49(3,4)5)53-33(2)57)42(27-35)63-26-16-12-10-8-6-7-9-11-13-19-43(59)54-37-24-22-34(23-25-37)46(60)55-40-18-15-14-17-39(40)50/h14-15,17-18,20-25,27,31,38,41,45,58H,6-13,16,19,26,28-30,50H2,1-5H3,(H,51,61)(H,53,57)(H,54,59)(H,55,60)/t38-,41+,45-/m1/s1","XPJGKIYHVFVWKJ-XVYMMXEDSA-N"
"2439","O15379","HDAC3","VHL","","JPS036","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)=C2)SC=N1","440","77","Degradation of HDAC3 in HCT116 cells after 24 h treatment","","","9670","IC50 of HDAC3-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","940.196","939.472846672","8.28","67","6","10","6","23","205.08","C51H66FN7O7S","InChI=1S/C51H66FN7O7S/c1-33-44(67-32-55-33)35-19-20-36(30-54-47(63)41-29-38(60)31-59(41)48(64)45(50(2,3)4)58-49(65)51(52)25-26-51)42(28-35)66-27-15-11-9-7-5-6-8-10-12-18-43(61)56-37-23-21-34(22-24-37)46(62)57-40-17-14-13-16-39(40)53/h13-14,16-17,19-24,28,32,38,41,45,60H,5-12,15,18,25-27,29-31,53H2,1-4H3,(H,54,63)(H,56,61)(H,57,62)(H,58,65)/t38-,41+,45-/m1/s1","NAADBQUVFJWCFU-XVYMMXEDSA-N"
"2439","Q13547","HDAC1","VHL","","JPS036","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)=C2)SC=N1","","45","Degradation of HDAC1 in HCT116 cells after 24 h treatment","","","61690","IC50 of HDAC1-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","940.196","939.472846672","8.28","67","6","10","6","23","205.08","C51H66FN7O7S","InChI=1S/C51H66FN7O7S/c1-33-44(67-32-55-33)35-19-20-36(30-54-47(63)41-29-38(60)31-59(41)48(64)45(50(2,3)4)58-49(65)51(52)25-26-51)42(28-35)66-27-15-11-9-7-5-6-8-10-12-18-43(61)56-37-23-21-34(22-24-37)46(62)57-40-17-14-13-16-39(40)53/h13-14,16-17,19-24,28,32,38,41,45,60H,5-12,15,18,25-27,29-31,53H2,1-4H3,(H,54,63)(H,56,61)(H,57,62)(H,58,65)/t38-,41+,45-/m1/s1","NAADBQUVFJWCFU-XVYMMXEDSA-N"
"2439","Q92769","HDAC2","VHL","","JPS036","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCCCCCCCCCC(=O)NC3=CC=C(C(=O)NC4=CC=CC=C4N)C=C3)=C2)SC=N1","","23","Degradation of HDAC2 in HCT116 cells after 24 h treatment","","","28380","IC50 of HDAC2-CoREST-LSD1 was assessed by a fluorescent HDAC assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c02179","940.196","939.472846672","8.28","67","6","10","6","23","205.08","C51H66FN7O7S","InChI=1S/C51H66FN7O7S/c1-33-44(67-32-55-33)35-19-20-36(30-54-47(63)41-29-38(60)31-59(41)48(64)45(50(2,3)4)58-49(65)51(52)25-26-51)42(28-35)66-27-15-11-9-7-5-6-8-10-12-18-43(61)56-37-23-21-34(22-24-37)46(62)57-40-17-14-13-16-39(40)53/h13-14,16-17,19-24,28,32,38,41,45,60H,5-12,15,18,25-27,29-31,53H2,1-4H3,(H,54,63)(H,56,61)(H,57,62)(H,58,65)/t38-,41+,45-/m1/s1","NAADBQUVFJWCFU-XVYMMXEDSA-N"
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"2486","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCCCCOC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","530/470/390","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","765.916","765.396230352","4.58","56","7","12","3","16","172.39","C41H51N9O6","InChI=1S/C41H51N9O6/c1-26(2)31-24-43-50-37(31)46-41(56-29-18-20-48(3)21-19-29)47-40(50)42-23-27-12-14-28(15-13-27)44-35(51)11-6-4-5-7-22-55-34-10-8-9-30-32(34)25-49(39(30)54)33-16-17-36(52)45-38(33)53/h8-10,12-15,24,26,29,33H,4-7,11,16-23,25H2,1-3H3,(H,44,51)(H,42,46,47)(H,45,52,53)","REEBZERREFABMH-UHFFFAOYSA-N"
"2487","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCCCOC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","470/370/570","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","751.889","751.380580288","4.04","55","7","12","3","15","172.39","C40H49N9O6","InChI=1S/C40H49N9O6/c1-25(2)30-23-42-49-36(30)45-40(55-28-17-19-47(3)20-18-28)46-39(49)41-22-26-11-13-27(14-12-26)43-34(50)10-5-4-6-21-54-33-9-7-8-29-31(33)24-48(38(29)53)32-15-16-35(51)44-37(32)52/h7-9,11-14,23,25,28,32H,4-6,10,15-22,24H2,1-3H3,(H,43,50)(H,41,45,46)(H,44,51,52)","WCIBWZLLCOFOEA-UHFFFAOYSA-N"
"2488","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130/230/200","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","749.917","749.401315732","5.24","55","7","11","3","15","163.16","C41H51N9O5","InChI=1S/C41H51N9O5/c1-26(2)32-24-43-50-37(32)46-41(55-30-19-21-48(3)22-20-30)47-40(50)42-23-27-13-15-29(16-14-27)44-35(51)12-7-5-4-6-9-28-10-8-11-31-33(28)25-49(39(31)54)34-17-18-36(52)45-38(34)53/h8,10-11,13-16,24,26,30,34H,4-7,9,12,17-23,25H2,1-3H3,(H,44,51)(H,42,46,47)(H,45,52,53)","TUFMZPWLCZNPPG-UHFFFAOYSA-N"
"2489","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCCCN4CCN(CCCCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","222/80/251","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","890.147","889.532664244","5.43","65","8","13","3","20","169.64","C49H67N11O5","InChI=1S/C49H67N11O5/c1-34(2)40-32-51-60-45(40)54-49(65-38-21-25-56(3)26-22-38)55-48(60)50-31-35-15-17-37(18-16-35)52-43(61)14-7-5-9-24-58-29-27-57(28-30-58)23-8-4-6-11-36-12-10-13-39-41(36)33-59(47(39)64)42-19-20-44(62)53-46(42)63/h10,12-13,15-18,32,34,38,42H,4-9,11,14,19-31,33H2,1-3H3,(H,52,61)(H,50,54,55)(H,53,62,63)","SCSHYDIRGPXXHE-UHFFFAOYSA-N"
"2490","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCN4CCN(CCCCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","340/190/460","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","862.093","861.501364116","4.72","63","8","13","3","18","169.64","C47H63N11O5","InChI=1S/C47H63N11O5/c1-32(2)38-30-49-58-43(38)52-47(63-36-19-23-54(3)24-20-36)53-46(58)48-29-33-13-15-35(16-14-33)50-41(59)12-8-22-56-27-25-55(26-28-56)21-6-4-5-9-34-10-7-11-37-39(34)31-57(45(37)62)40-17-18-42(60)51-44(40)61/h7,10-11,13-16,30,32,36,40H,4-6,8-9,12,17-29,31H2,1-3H3,(H,50,59)(H,48,52,53)(H,51,60,61)","DRZSHVSTRZVBDA-UHFFFAOYSA-N"
"2491","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCCCN4CCN(CCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","240/190/250","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","862.093","861.501364116","4.53","63","8","13","3","18","169.64","C47H63N11O5","InChI=1S/C47H63N11O5/c1-32(2)38-30-49-58-43(38)52-47(63-36-19-23-54(3)24-20-36)53-46(58)48-29-33-13-15-35(16-14-33)50-41(59)12-5-4-6-21-55-25-27-56(28-26-55)22-8-10-34-9-7-11-37-39(34)31-57(45(37)62)40-17-18-42(60)51-44(40)61/h7,9,11,13-16,30,32,36,40H,4-6,8,10,12,17-29,31H2,1-3H3,(H,50,59)(H,48,52,53)(H,51,60,61)","WLJYLCXUUZROCL-UHFFFAOYSA-N"
"2492","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)CCCN4CCN(CCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","590/580/900","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","834.039","833.470063988","3.82","61","8","13","3","16","169.64","C45H59N11O5","InChI=1S/C45H59N11O5/c1-30(2)36-28-47-56-41(36)50-45(61-34-17-21-52(3)22-18-34)51-44(56)46-27-31-11-13-33(14-12-31)48-39(57)10-6-20-54-25-23-53(24-26-54)19-5-8-32-7-4-9-35-37(32)29-55(43(35)60)38-15-16-40(58)49-42(38)59/h4,7,9,11-14,28,30,34,38H,5-6,8,10,15-27,29H2,1-3H3,(H,48,57)(H,46,50,51)(H,49,58,59)","REUXTJMXDJZRTP-UHFFFAOYSA-N"
"2493","P50750","CDK9","CRBN","","","CC(C)C1=C2N=C(OC3CCN(C)CC3)N=C(NCC3=CC=C(NC(=O)N4CCN(CCCCCC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)N2N=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","98/74/65","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","820.012","819.454413924","4.4","60","8","12","3","14","169.64","C44H57N11O5","InChI=1S/C44H57N11O5/c1-29(2)35-27-46-55-39(35)49-43(60-33-17-20-51(3)21-18-33)50-42(55)45-26-30-11-13-32(14-12-30)47-44(59)53-24-22-52(23-25-53)19-6-4-5-8-31-9-7-10-34-36(31)28-54(41(34)58)37-15-16-38(56)48-40(37)57/h7,9-14,27,29,33,37H,4-6,8,15-26,28H2,1-3H3,(H,47,59)(H,45,49,50)(H,48,56,57)","UJFIRAYRNIBTHQ-UHFFFAOYSA-N"
"2494","P50750","CDK9","CRBN","","","CC[C@@H](CO)NC1=NC2=C(C(C)C)C=NN2C(NCC2=CC=C(NC(=O)N3CCN(CCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)C=C2)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15/3.9/13.6","Inhibit growth of MDA-MB-468/BT-549/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01350","792.986","792.443514892","4.33","58","7","11","5","16","176.54","C43H56N10O5","InChI=1S/C43H56N10O5/c1-4-31(27-54)46-37-23-38(53-40(48-37)34(25-45-53)28(2)3)44-24-29-12-14-32(15-13-29)47-43(58)51-21-19-50(20-22-51)18-7-5-6-9-30-10-8-11-33-35(30)26-52(42(33)57)36-16-17-39(55)49-41(36)56/h8,10-15,23,25,28,31,36,44,54H,4-7,9,16-22,24,26-27H2,1-3H3,(H,46,48)(H,47,58)(H,49,55,56)/t31-,36?/m0/s1","YAEBZMQWNHWNAG-BRKUKBBPSA-N"
"2495","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","1","85","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","683.165","682.23066052","4.77","49","6","9","4","11","169.73","C36H35ClN6O6","InChI=1S/C36H35ClN6O6/c37-30-19-27(10-4-22(30)20-38)49-26-11-7-24(8-12-26)41-33(45)21-2-5-23(6-3-21)39-16-1-17-40-25-9-13-28-29(18-25)36(48)43(35(28)47)31-14-15-32(44)42-34(31)46/h2-6,9-10,13,18-19,24,26,31,39-40H,1,7-8,11-12,14-17H2,(H,41,45)(H,42,44,46)/t24-,26-,31?","XLWFMSWFAKUJON-QYYYJOFJSA-N"
"2496","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","1.1","89","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","697.192","696.246310584","5.13","50","6","9","4","12","169.73","C37H37ClN6O6","InChI=1S/C37H37ClN6O6/c38-31-20-28(11-5-23(31)21-39)50-27-12-8-25(9-13-27)42-34(46)22-3-6-24(7-4-22)40-17-1-2-18-41-26-10-14-29-30(19-26)37(49)44(36(29)48)32-15-16-33(45)43-35(32)47/h3-7,10-11,14,19-20,25,27,32,40-41H,1-2,8-9,12-13,15-18H2,(H,42,46)(H,43,45,47)/t25-,27-,32?","SEKBVYVWYRALIG-COJZMJFXSA-N"
"2497","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","0.2","95","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","711.219","710.261960648","5.49","51","6","9","4","13","169.73","C38H39ClN6O6","InChI=1S/C38H39ClN6O6/c39-32-21-29(12-6-24(32)22-40)51-28-13-9-26(10-14-28)43-35(47)23-4-7-25(8-5-23)41-18-2-1-3-19-42-27-11-15-30-31(20-27)38(50)45(37(30)49)33-16-17-34(46)44-36(33)48/h4-8,11-12,15,20-21,26,28,33,41-42H,1-3,9-10,13-14,16-19H2,(H,43,47)(H,44,46,48)/t26-,28-,33?","FZVBQSWNRMPEHR-NBAFNCFLSA-N"
"2498","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","0.6","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","725.246","724.277610712","5.84","52","6","9","4","14","169.73","C39H41ClN6O6","InChI=1S/C39H41ClN6O6/c40-33-22-30(13-7-25(33)23-41)52-29-14-10-27(11-15-29)44-36(48)24-5-8-26(9-6-24)42-19-3-1-2-4-20-43-28-12-16-31-32(21-28)39(51)46(38(31)50)34-17-18-35(47)45-37(34)49/h5-9,12-13,16,21-22,27,29,34,42-43H,1-4,10-11,14-15,17-20H2,(H,44,48)(H,45,47,49)/t27-,29-,34?","SLYLTYLJUFVQPH-BKPPXGSPSA-N"
"2499","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","0.7","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","739.273","738.293260776","6.38","53","6","9","4","15","169.73","C40H43ClN6O6","InChI=1S/C40H43ClN6O6/c41-34-23-31(14-8-26(34)24-42)53-30-15-11-28(12-16-30)45-37(49)25-6-9-27(10-7-25)43-20-4-2-1-3-5-21-44-29-13-17-32-33(22-29)40(52)47(39(32)51)35-18-19-36(48)46-38(35)50/h6-10,13-14,17,22-23,28,30,35,43-44H,1-5,11-12,15-16,18-21H2,(H,45,49)(H,46,48,50)/t28-,30-,35?","KLUHWCISGKYNHH-KGNGEQPNSA-N"
"2500","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","1.5","97","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","753.3","752.30891084","6.93","54","6","9","4","16","169.73","C41H45ClN6O6","InChI=1S/C41H45ClN6O6/c42-35-24-32(15-9-27(35)25-43)54-31-16-12-29(13-17-31)46-38(50)26-7-10-28(11-8-26)44-21-5-3-1-2-4-6-22-45-30-14-18-33-34(23-30)41(53)48(40(33)52)36-19-20-37(49)47-39(36)51/h7-11,14-15,18,23-24,29,31,36,44-45H,1-6,12-13,16-17,19-22H2,(H,46,50)(H,47,49,51)/t29-,31-,36?","LIAPRZHHMHGLCS-NSGDDVBOSA-N"
"2501","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl","3.2","96","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","767.327","766.324560904","7.47","55","6","9","4","17","169.73","C42H47ClN6O6","InChI=1S/C42H47ClN6O6/c43-36-25-33(16-10-28(36)26-44)55-32-17-13-30(14-18-32)47-39(51)27-8-11-29(12-9-27)45-22-6-4-2-1-3-5-7-23-46-31-15-19-34-35(24-31)42(54)49(41(34)53)37-20-21-38(50)48-40(37)52/h8-12,15-16,19,24-25,30,32,37,45-46H,1-7,13-14,17-18,20-23H2,(H,47,51)(H,48,50,52)/t30-,32-,37?","VSYZSMLAOKWORE-GUJMKDNBSA-N"
"2502","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl",">1000","25","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","781.354","780.340210968","8.01","56","6","9","4","18","169.73","C43H49ClN6O6","InChI=1S/C43H49ClN6O6/c44-37-26-34(17-11-29(37)27-45)56-33-18-14-31(15-19-33)48-40(52)28-9-12-30(13-10-28)46-23-7-5-3-1-2-4-6-8-24-47-32-16-20-35-36(25-32)43(55)50(42(35)54)38-21-22-39(51)49-41(38)53/h9-13,16-17,20,25-26,31,33,38,46-47H,1-8,14-15,18-19,21-24H2,(H,48,52)(H,49,51,53)/t31-,33-,38?","RJFFRTWDHINENB-GCVZDEPESA-N"
"2503","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(NCCCCCCCCCCCNC4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)C=C3)CC2)C=C1Cl",">1000","42","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","795.381","794.355861032","8.55","57","6","9","4","19","169.73","C44H51ClN6O6","InChI=1S/C44H51ClN6O6/c45-38-27-35(18-12-30(38)28-46)57-34-19-15-32(16-20-34)49-41(53)29-10-13-31(14-11-29)47-24-8-6-4-2-1-3-5-7-9-25-48-33-17-21-36-37(26-33)44(56)51(43(36)55)39-22-23-40(52)50-42(39)54/h10-14,17-18,21,26-27,32,34,39,47-48H,1-9,15-16,19-20,22-25H2,(H,49,53)(H,50,52,54)/t32-,34-,39?","KPYLNSRIYNAOJF-RIZDTZEESA-N"
"2504","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C=C3)CC2)C=C1Cl","0.8","77","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","738.245","737.27285968","4.36","53","7","10","3","10","164.18","C39H40ClN7O6","InChI=1S/C39H40ClN7O6/c40-33-22-30(9-3-25(33)23-41)53-29-10-4-26(5-11-29)43-36(49)24-1-7-28(8-2-24)46-19-17-45(18-20-46)16-15-42-27-6-12-31-32(21-27)39(52)47(38(31)51)34-13-14-35(48)44-37(34)50/h1-3,6-9,12,21-22,26,29,34,42H,4-5,10-11,13-20H2,(H,43,49)(H,44,48,50)/t26-,29-,34?","KUCKATJPXILIRH-BPHARUEYSA-N"
"2505","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C=C3)CC2)C=C1Cl","2.7","82","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","752.272","751.288509744","4.72","54","7","10","3","11","164.18","C40H42ClN7O6","InChI=1S/C40H42ClN7O6/c41-34-23-31(10-4-26(34)24-42)54-30-11-5-27(6-12-30)44-37(50)25-2-8-29(9-3-25)47-20-18-46(19-21-47)17-1-16-43-28-7-13-32-33(22-28)40(53)48(39(32)52)35-14-15-36(49)45-38(35)51/h2-4,7-10,13,22-23,27,30,35,43H,1,5-6,11-12,14-21H2,(H,44,50)(H,45,49,51)/t27-,30-,35?","IOIPLMHHWKGICH-LFUVDIOQSA-N"
"2506","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C=C3)CC2)C=C1Cl","16.2","67","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","766.299","765.304159808","5.08","55","7","10","3","12","164.18","C41H44ClN7O6","InChI=1S/C41H44ClN7O6/c42-35-24-32(11-5-27(35)25-43)55-31-12-6-28(7-13-31)45-38(51)26-3-9-30(10-4-26)48-21-19-47(20-22-48)18-2-1-17-44-29-8-14-33-34(23-29)41(54)49(40(33)53)36-15-16-37(50)46-39(36)52/h3-5,8-11,14,23-24,28,31,36,44H,1-2,6-7,12-13,15-22H2,(H,45,51)(H,46,50,52)/t28-,31-,36?","QFBDIBRAVHTJHW-HDGSNFBOSA-N"
"2507","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CCCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C=C3)CC2)C=C1Cl","0.9","85","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","780.326","779.319809872","5.44","56","7","10","3","13","164.18","C42H46ClN7O6","InChI=1S/C42H46ClN7O6/c43-36-25-33(12-6-28(36)26-44)56-32-13-7-29(8-14-32)46-39(52)27-4-10-31(11-5-27)49-22-20-48(21-23-49)19-3-1-2-18-45-30-9-15-34-35(24-30)42(55)50(41(34)54)37-16-17-38(51)47-40(37)53/h4-6,9-12,15,24-25,29,32,37,45H,1-3,7-8,13-14,16-23H2,(H,46,52)(H,47,51,53)/t29-,32-,37?","RIBBYHBSLKRREX-MLUZTVPMSA-N"
"2508","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CC5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl","0.2","97","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.7","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","792.337","791.319809872","5.25","57","8","10","2","9","155.39","C43H46ClN7O6","InChI=1S/C43H46ClN7O6/c44-37-24-34(9-3-29(37)25-45)57-33-10-4-30(5-11-33)46-40(53)28-1-6-31(7-2-28)50-21-19-48(20-22-50)26-27-15-17-49(18-16-27)32-8-12-35-36(23-32)43(56)51(42(35)55)38-13-14-39(52)47-41(38)54/h1-3,6-9,12,23-24,27,30,33,38H,4-5,10-11,13-22,26H2,(H,46,53)(H,47,52,54)/t30-,33-,38?","QJZUVOHJKPMREF-SIOTYANSSA-N"
"2509","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(C5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl","0.3","88","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.9","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","778.31","777.304159808","5.06","56","8","10","2","8","155.39","C42H44ClN7O6","InChI=1S/C42H44ClN7O6/c43-36-24-33(9-3-27(36)25-44)56-32-10-4-28(5-11-32)45-39(52)26-1-6-29(7-2-26)48-19-21-49(22-20-48)30-15-17-47(18-16-30)31-8-12-34-35(23-31)42(55)50(41(34)54)37-13-14-38(51)46-40(37)53/h1-3,6-9,12,23-24,28,30,32,37H,4-5,10-11,13-22H2,(H,45,52)(H,46,51,53)/t28-,32-,37?","SRMKEEIRTHASLG-MVHOYPFPSA-N"
"2510","P10275","AR T878A","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","778.31","777.304159808","5.06","56","8","10","2","8","155.39","C42H44ClN7O6","InChI=1S/C42H44ClN7O6/c43-36-24-33(9-3-27(36)25-44)56-32-10-4-28(5-11-32)45-39(52)26-1-6-29(7-2-26)47-17-15-30(16-18-47)48-19-21-49(22-20-48)31-8-12-34-35(23-31)42(55)50(41(34)54)37-13-14-38(51)46-40(37)53/h1-3,6-9,12,23-24,28,30,32,37H,4-5,10-11,13-22H2,(H,45,52)(H,46,51,53)/t28-,32-,37?","ZEEFAZNIKLZENT-MVHOYPFPSA-N"
"2510","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl","0.2","95","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.7","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","778.31","777.304159808","5.06","56","8","10","2","8","155.39","C42H44ClN7O6","InChI=1S/C42H44ClN7O6/c43-36-24-33(9-3-27(36)25-44)56-32-10-4-28(5-11-32)45-39(52)26-1-6-29(7-2-26)47-17-15-30(16-18-47)48-19-21-49(22-20-48)31-8-12-34-35(23-31)42(55)50(41(34)54)37-13-14-38(51)46-40(37)53/h1-3,6-9,12,23-24,28,30,32,37H,4-5,10-11,13-22H2,(H,45,52)(H,46,51,53)/t28-,32-,37?","ZEEFAZNIKLZENT-MVHOYPFPSA-N"
"2511","P10275","AR T878A","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CC5CN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)CC4)C=C3)CC2)C=C1Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","764.283","763.288509744","4.53","55","8","10","2","9","155.39","C41H42ClN7O6","InChI=1S/C41H42ClN7O6/c42-35-20-32(9-3-27(35)21-43)55-31-10-4-28(5-11-31)44-38(51)26-1-6-29(7-2-26)47-17-15-46(16-18-47)22-25-23-48(24-25)30-8-12-33-34(19-30)41(54)49(40(33)53)36-13-14-37(50)45-39(36)52/h1-3,6-9,12,19-20,25,28,31,36H,4-5,10-11,13-18,22-24H2,(H,44,51)(H,45,50,52)/t28-,31-,36?","ZXOIALMBAAMQKG-HDGSNFBOSA-N"
"2511","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(CC5CN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)CC4)C=C3)CC2)C=C1Cl","0.3","92","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6.7","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","764.283","763.288509744","4.53","55","8","10","2","9","155.39","C41H42ClN7O6","InChI=1S/C41H42ClN7O6/c42-35-20-32(9-3-27(35)21-43)55-31-10-4-28(5-11-31)44-38(51)26-1-6-29(7-2-26)47-17-15-46(16-18-47)22-25-23-48(24-25)30-8-12-33-34(19-30)41(54)49(40(33)53)36-13-14-37(50)45-39(36)52/h1-3,6-9,12,19-20,25,28,31,36H,4-5,10-11,13-18,22-24H2,(H,44,51)(H,45,50,52)/t28-,31-,36?","ZXOIALMBAAMQKG-HDGSNFBOSA-N"
"2512","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCN(C5CN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)CC4)C=C3)CC2)C=C1Cl","0.1","76","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","750.256","749.27285968","4.34","54","8","10","2","8","155.39","C40H40ClN7O6","InChI=1S/C40H40ClN7O6/c41-34-20-31(9-3-25(34)21-42)54-30-10-4-26(5-11-30)43-37(50)24-1-6-27(7-2-24)45-15-17-46(18-16-45)29-22-47(23-29)28-8-12-32-33(19-28)40(53)48(39(32)52)35-13-14-36(49)44-38(35)51/h1-3,6-9,12,19-20,26,29-30,35H,4-5,10-11,13-18,22-23H2,(H,43,50)(H,44,49,51)/t26-,30-,35?","IFCKDGNCNVHZTM-KEQPVMAKSA-N"
"2513","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)C2)C=C1Cl",">1000","20","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","764.283","763.288509744","4.7","55","8","10","2","8","155.39","C41H42ClN7O6","InChI=1S/C41H42ClN7O6/c42-35-23-32(8-3-26(35)24-43)55-31-9-4-27(21-31)44-38(51)25-1-5-28(6-2-25)46-15-13-29(14-16-46)47-17-19-48(20-18-47)30-7-10-33-34(22-30)41(54)49(40(33)53)36-11-12-37(50)45-39(36)52/h1-3,5-8,10,22-23,27,29,31,36H,4,9,11-21H2,(H,44,51)(H,45,50,52)/t27-,31-,36?/m0/s1","GXUBCAYGWJGCKT-SVYXOXRISA-N"
"2514","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@@H]2CCC[C@@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl",">1000","45","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","792.337","791.319809872","5.42","57","8","10","2","8","155.39","C43H46ClN7O6","InChI=1S/C43H46ClN7O6/c44-37-25-34(11-6-28(37)26-45)57-33-3-1-2-29(7-12-33)46-40(53)27-4-8-30(9-5-27)48-18-16-31(17-19-48)49-20-22-50(23-21-49)32-10-13-35-36(24-32)43(56)51(42(35)55)38-14-15-39(52)47-41(38)54/h4-6,8-11,13,24-25,29,31,33,38H,1-3,7,12,14-23H2,(H,46,53)(H,47,52,54)/t29-,33-,38?/m1/s1","VGXZUMFEKIFIQW-UCRZJGTBSA-N"
"2515","P10275","AR","CRBN","","","N#CC1=CC=C(O[C@H]2CCC[C@@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CCC2)C=C1Cl",">1000","54","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","806.364","805.335459936","5.77","58","8","10","2","8","155.39","C44H48ClN7O6","InChI=1S/C44H48ClN7O6/c45-38-26-35(13-9-29(38)27-46)58-34-5-1-3-30(4-2-6-34)47-41(54)28-7-10-31(11-8-28)49-19-17-32(18-20-49)50-21-23-51(24-22-50)33-12-14-36-37(25-33)44(57)52(43(36)56)39-15-16-40(53)48-42(39)55/h7-14,25-26,30,32,34,39H,1-6,15-24H2,(H,47,54)(H,48,53,55)/t30-,34+,39?","LOWACICYXXELEY-GDMVNCDBSA-N"
"2516","P10275","AR","CRBN","","","N#CC1=CC=C(OC2CCN(C(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl",">1000","19","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","764.283","763.288509744","4.46","55","8","10","1","7","146.6","C41H42ClN7O6","InChI=1S/C41H42ClN7O6/c42-35-24-32(7-3-27(35)25-43)55-31-13-17-48(18-14-31)39(52)26-1-4-28(5-2-26)45-15-11-29(12-16-45)46-19-21-47(22-20-46)30-6-8-33-34(23-30)41(54)49(40(33)53)36-9-10-37(50)44-38(36)51/h1-8,23-24,29,31,36H,9-22H2,(H,44,50,51)","RACWFSYZHXHUJV-UHFFFAOYSA-N"
"2517","P10275","AR","CRBN","","","N#CC1=CC=C(OC2CCCN(C(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl",">1000","35","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","778.31","777.304159808","4.82","56","8","10","1","7","146.6","C42H44ClN7O6","InChI=1S/C42H44ClN7O6/c43-36-25-33(9-5-28(36)26-44)56-32-2-1-16-49(19-15-32)40(53)27-3-6-29(7-4-27)46-17-13-30(14-18-46)47-20-22-48(23-21-47)31-8-10-34-35(24-31)42(55)50(41(34)54)37-11-12-38(51)45-39(37)52/h3-10,24-25,30,32,37H,1-2,11-23H2,(H,45,51,52)","SWYBGHSSRFVKQG-UHFFFAOYSA-N"
"2518","P10275","AR","CRBN","","","N#CC1=CC=C(N[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C=C3)CC2)C=C1Cl","0.3","78","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16.6","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","777.326","776.32014422","5.07","56","8","10","3","8","158.19","C42H45ClN8O5","InChI=1S/C42H45ClN8O5/c43-36-23-30(4-1-27(36)25-44)45-28-5-7-29(8-6-28)46-39(53)26-2-9-31(10-3-26)48-17-15-32(16-18-48)49-19-21-50(22-20-49)33-11-12-34-35(24-33)42(56)51(41(34)55)37-13-14-38(52)47-40(37)54/h1-4,9-12,23-24,28-29,32,37,45H,5-8,13-22H2,(H,46,53)(H,47,52,54)/t28-,29-,37?","IRDHCECVXOCRLY-QZHRDHLUSA-N"
"2519","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.09","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.8","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","791.353","790.335794284","5.21","57","8","10","2","8","149.4","C43H47ClN8O5","InChI=1S/C43H47ClN8O5/c1-48(33-9-4-28(26-45)37(44)25-33)30-10-5-29(6-11-30)46-40(54)27-2-7-31(8-3-27)49-18-16-32(17-19-49)50-20-22-51(23-21-50)34-12-13-35-36(24-34)43(57)52(42(35)56)38-14-15-39(53)47-41(38)55/h2-4,7-9,12-13,24-25,29-30,32,38H,5-6,10-11,14-23H2,1H3,(H,46,54)(H,47,53,55)/t29-,30-,38?","BEEAHZAQHFFDHP-KIIACXQNSA-N"
"2519","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.3","95","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.3","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","791.353","790.335794284","5.21","57","8","10","2","8","149.4","C43H47ClN8O5","InChI=1S/C43H47ClN8O5/c1-48(33-9-4-28(26-45)37(44)25-33)30-10-5-29(6-11-30)46-40(54)27-2-7-31(8-3-27)49-18-16-32(17-19-49)50-20-22-51(23-21-50)34-12-13-35-36(24-34)43(57)52(42(35)56)38-14-15-39(53)47-41(38)55/h2-4,7-9,12-13,24-25,29-30,32,38H,5-6,10-11,14-23H2,1H3,(H,46,54)(H,47,53,55)/t29-,30-,38?","BEEAHZAQHFFDHP-KIIACXQNSA-N"
"2520","P10275","AR","CRBN","","","CCN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.1","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.1","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","805.38","804.351444348","5.58","58","8","10","2","9","149.4","C44H49ClN8O5","InChI=1S/C44H49ClN8O5/c1-2-52(35-10-5-29(27-46)38(45)26-35)33-11-6-30(7-12-33)47-41(55)28-3-8-31(9-4-28)49-19-17-32(18-20-49)50-21-23-51(24-22-50)34-13-14-36-37(25-34)44(58)53(43(36)57)39-15-16-40(54)48-42(39)56/h3-5,8-10,13-14,25-26,30,32-33,39H,2,6-7,11-12,15-24H2,1H3,(H,47,55)(H,48,54,56)/t30-,33-,39?","VZVAWYNZTBXESG-BULKPCKOSA-N"
"2521","P10275","AR","CRBN","","","CCCN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","1.4","88","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","83.5","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","819.407","818.367094412","6.1","59","8","10","2","10","149.4","C45H51ClN8O5","InChI=1S/C45H51ClN8O5/c1-2-19-53(36-10-5-30(28-47)39(46)27-36)34-11-6-31(7-12-34)48-42(56)29-3-8-32(9-4-29)50-20-17-33(18-21-50)51-22-24-52(25-23-51)35-13-14-37-38(26-35)45(59)54(44(37)58)40-15-16-41(55)49-43(40)57/h3-5,8-10,13-14,26-27,31,33-34,40H,2,6-7,11-12,15-25H2,1H3,(H,48,56)(H,49,55,57)/t31-,34-,40?","FVEFTVCRDXCSLR-MLTFQQHKSA-N"
"2522","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(CC4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","1.4","93","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","805.38","804.351444348","5.4","58","8","10","2","9","149.4","C44H49ClN8O5","InChI=1S/C44H49ClN8O5/c1-49(34-9-4-30(26-46)38(45)25-34)32-10-5-31(6-11-32)47-41(55)29-2-7-33(8-3-29)52-22-20-50(21-23-52)27-28-16-18-51(19-17-28)35-12-13-36-37(24-35)44(58)53(43(36)57)39-14-15-40(54)48-42(39)56/h2-4,7-9,12-13,24-25,28,31-32,39H,5-6,10-11,14-23,27H2,1H3,(H,47,55)(H,48,54,56)/t31-,32-,39?","FSMCKEYFGVIYBM-WIDQNFKDSA-N"
"2523","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCC(CN4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.5","96","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","805.38","804.351444348","5.4","58","8","10","2","9","149.4","C44H49ClN8O5","InChI=1S/C44H49ClN8O5/c1-49(34-9-4-30(26-46)38(45)25-34)32-10-5-31(6-11-32)47-41(55)29-2-7-33(8-3-29)51-18-16-28(17-19-51)27-50-20-22-52(23-21-50)35-12-13-36-37(24-35)44(58)53(43(36)57)39-14-15-40(54)48-42(39)56/h2-4,7-9,12-13,24-25,28,31-32,39H,5-6,10-11,14-23,27H2,1H3,(H,47,55)(H,48,54,56)/t31-,32-,39?","XLQOXOVXCNIRJP-WIDQNFKDSA-N"
"2524","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.1","96","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.8","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","791.353","790.335794284","5.21","57","8","10","2","8","149.4","C43H47ClN8O5","InChI=1S/C43H47ClN8O5/c1-48(33-9-4-28(26-45)37(44)25-33)30-10-5-29(6-11-30)46-40(54)27-2-7-31(8-3-27)50-20-22-51(23-21-50)32-16-18-49(19-17-32)34-12-13-35-36(24-34)43(57)52(42(35)56)38-14-15-39(53)47-41(38)55/h2-4,7-9,12-13,24-25,29-30,32,38H,5-6,10-11,14-23H2,1H3,(H,46,54)(H,47,53,55)/t29-,30-,38?","WHJVBMNCPUFBSX-KIIACXQNSA-N"
"2524","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)C=C2)CC1","0.4","95","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22.3","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","791.353","790.335794284","5.21","57","8","10","2","8","149.4","C43H47ClN8O5","InChI=1S/C43H47ClN8O5/c1-48(33-9-4-28(26-45)37(44)25-33)30-10-5-29(6-11-30)46-40(54)27-2-7-31(8-3-27)50-20-22-51(23-21-50)32-16-18-49(19-17-32)34-12-13-35-36(24-34)43(57)52(42(35)56)38-14-15-39(53)47-41(38)55/h2-4,7-9,12-13,24-25,29-30,32,38H,5-6,10-11,14-23H2,1H3,(H,46,54)(H,47,53,55)/t29-,30-,38?","WHJVBMNCPUFBSX-KIIACXQNSA-N"
"2525","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(CC4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)CC1","0.01","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.1","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","777.326","776.32014422","4.69","56","8","10","2","9","149.4","C42H45ClN8O5","InChI=1S/C42H45ClN8O5/c1-47(32-9-4-28(22-44)36(43)21-32)30-10-5-29(6-11-30)45-39(53)27-2-7-31(8-3-27)49-18-16-48(17-19-49)23-26-24-50(25-26)33-12-13-34-35(20-33)42(56)51(41(34)55)37-14-15-38(52)46-40(37)54/h2-4,7-9,12-13,20-21,26,29-30,37H,5-6,10-11,14-19,23-25H2,1H3,(H,45,53)(H,46,52,54)/t29-,30-,37?","YYULHFDWXXZSRM-VZASAIHWSA-N"
"2525","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(CC4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)CC1","0.9","99","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.4","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","777.326","776.32014422","4.69","56","8","10","2","9","149.4","C42H45ClN8O5","InChI=1S/C42H45ClN8O5/c1-47(32-9-4-28(22-44)36(43)21-32)30-10-5-29(6-11-30)45-39(53)27-2-7-31(8-3-27)49-18-16-48(17-19-49)23-26-24-50(25-26)33-12-13-34-35(20-33)42(56)51(41(34)55)37-14-15-38(52)46-40(37)54/h2-4,7-9,12-13,20-21,26,29-30,37H,5-6,10-11,14-19,23-25H2,1H3,(H,45,53)(H,46,52,54)/t29-,30-,37?","YYULHFDWXXZSRM-VZASAIHWSA-N"
"2526","P10275","AR","CRBN","","ARD-2585","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(C4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)CC1","0.04","99","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.5","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","763.299","762.304494156","4.5","55","8","10","2","8","149.4","C41H43ClN8O5","InChI=1S/C41H43ClN8O5/c1-46(30-9-4-26(22-43)35(42)21-30)28-10-5-27(6-11-28)44-38(52)25-2-7-29(8-3-25)47-16-18-48(19-17-47)32-23-49(24-32)31-12-13-33-34(20-31)41(55)50(40(33)54)36-14-15-37(51)45-39(36)53/h2-4,7-9,12-13,20-21,27-28,32,36H,5-6,10-11,14-19,23-24H2,1H3,(H,44,52)(H,45,51,53)/t27-,28-,36?","LUCHABJUYSYJAT-RVWRWSNSSA-N"
"2526","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CCN(C4CN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C4)CC3)C=C2)CC1","0.1","98","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16.2","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","763.299","762.304494156","4.5","55","8","10","2","8","149.4","C41H43ClN8O5","InChI=1S/C41H43ClN8O5/c1-46(30-9-4-26(22-43)35(42)21-30)28-10-5-27(6-11-28)44-38(52)25-2-7-29(8-3-25)47-16-18-48(19-17-47)32-23-49(24-32)31-12-13-33-34(20-31)41(55)50(40(33)54)36-14-15-37(51)45-39(36)53/h2-4,7-9,12-13,20-21,27-28,32,36H,5-6,10-11,14-19,23-24H2,1H3,(H,44,52)(H,45,51,53)/t27-,28-,36?","LUCHABJUYSYJAT-RVWRWSNSSA-N"
"2527","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CC(CN4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)CC1","0.1","100","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.3","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","777.326","776.32014422","4.69","56","8","10","2","9","149.4","C42H45ClN8O5","InChI=1S/C42H45ClN8O5/c1-47(32-9-4-28(22-44)36(43)21-32)30-10-5-29(6-11-30)45-39(53)27-2-7-31(8-3-27)50-24-26(25-50)23-48-16-18-49(19-17-48)33-12-13-34-35(20-33)42(56)51(41(34)55)37-14-15-38(52)46-40(37)54/h2-4,7-9,12-13,20-21,26,29-30,37H,5-6,10-11,14-19,23-25H2,1H3,(H,45,53)(H,46,52,54)/t29-,30-,37?","LOFIFWMXRZZLIL-VZASAIHWSA-N"
"2527","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CC(CN4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)CC1","1.9","99","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.6","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","777.326","776.32014422","4.69","56","8","10","2","9","149.4","C42H45ClN8O5","InChI=1S/C42H45ClN8O5/c1-47(32-9-4-28(22-44)36(43)21-32)30-10-5-29(6-11-30)45-39(53)27-2-7-31(8-3-27)50-24-26(25-50)23-48-16-18-49(19-17-48)33-12-13-34-35(20-33)42(56)51(41(34)55)37-14-15-38(52)46-40(37)54/h2-4,7-9,12-13,20-21,26,29-30,37H,5-6,10-11,14-19,23-25H2,1H3,(H,45,53)(H,46,52,54)/t29-,30-,37?","LOFIFWMXRZZLIL-VZASAIHWSA-N"
"2528","P10275","AR","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)CC1","0.2","96","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.1","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","763.299","762.304494156","4.5","55","8","10","2","8","149.4","C41H43ClN8O5","InChI=1S/C41H43ClN8O5/c1-46(30-9-4-26(22-43)35(42)21-30)28-10-5-27(6-11-28)44-38(52)25-2-7-29(8-3-25)49-23-32(24-49)48-18-16-47(17-19-48)31-12-13-33-34(20-31)41(55)50(40(33)54)36-14-15-37(51)45-39(36)53/h2-4,7-9,12-13,20-21,27-28,32,36H,5-6,10-11,14-19,23-24H2,1H3,(H,44,52)(H,45,51,53)/t27-,28-,36?","RNZSZCNUPQYOIX-RVWRWSNSSA-N"
"2528","P10275","AR T878A","CRBN","","","CN(C1=CC=C(C#N)C(Cl)=C1)[C@H]1CC[C@H](NC(=O)C2=CC=C(N3CC(N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)CC1","1.3","64","Degradation of AR T878A in LNCaP (AR T878A) cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.7","Inhibit growth of LNCaP (AR T878A) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","763.299","762.304494156","4.5","55","8","10","2","8","149.4","C41H43ClN8O5","InChI=1S/C41H43ClN8O5/c1-46(30-9-4-26(22-43)35(42)21-30)28-10-5-27(6-11-28)44-38(52)25-2-7-29(8-3-25)49-23-32(24-49)48-18-16-47(17-19-48)31-12-13-33-34(20-31)41(55)50(40(33)54)36-14-15-37(51)45-39(36)53/h2-4,7-9,12-13,20-21,27-28,32,36H,5-6,10-11,14-19,23-24H2,1H3,(H,44,52)(H,45,51,53)/t27-,28-,36?","RNZSZCNUPQYOIX-RVWRWSNSSA-N"
"2529","P10275","AR","CRBN","","","CC(O)(CS(=O)(=O)C1=CC=C(N2CCN(C3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)C=C1)C(=O)NC1=CC=C(C#N)C(C(F)(F)F)=C1",">1000","32","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","835.862","835.2611169","2.72","59","7","12","3","9","200.53","C40H40F3N7O8S","InChI=1S/C40H40F3N7O8S/c1-39(56,38(55)45-25-3-2-24(22-44)32(20-25)40(41,42)43)23-59(57,58)29-7-4-26(5-8-29)48-16-18-49(19-17-48)27-12-14-47(15-13-27)28-6-9-30-31(21-28)37(54)50(36(30)53)33-10-11-34(51)46-35(33)52/h2-9,20-21,27,33,56H,10-19,23H2,1H3,(H,45,55)(H,46,51,52)","RDTWXYREPJFRLJ-UHFFFAOYSA-N"
"2530","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C(=O)N2CCN(C3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)C(F)=C1",">1000","14","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","858.875","858.257114816","4.18","61","8","10","1","6","157.68","C42H38F4N8O6S","InChI=1S/C42H38F4N8O6S/c1-41(2)39(60)52(26-4-3-23(22-47)31(20-26)42(44,45)46)40(61)54(41)27-6-8-29(32(43)21-27)36(57)51-17-15-50(16-18-51)24-11-13-49(14-12-24)25-5-7-28-30(19-25)38(59)53(37(28)58)33-9-10-34(55)48-35(33)56/h3-8,19-21,24,33H,9-18H2,1-2H3,(H,48,55,56)","GPZDKLVDAYMWLZ-UHFFFAOYSA-N"
"2531","P10275","AR","CRBN","","","N#CC1=NC=C(N2C(=O)C3(CCC3)N(C3=CC=C(C(=O)N4CCN(C5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)C(F)=C3)C2=S)C=C1C(F)(F)F",">1000","27","Degradation of AR in VCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit growth of VCaP cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00900","871.874","871.252363784","3.55","62","9","11","1","6","170.57","C42H37F4N9O6S","InChI=1S/C42H37F4N9O6S/c43-31-20-25(55-40(62)53(39(61)41(55)10-1-11-41)26-19-30(42(44,45)46)32(21-47)48-22-26)3-5-28(31)36(58)52-16-14-51(15-17-52)23-8-12-50(13-9-23)24-2-4-27-29(18-24)38(60)54(37(27)59)33-6-7-34(56)49-35(33)57/h2-5,18-20,22-23,33H,1,6-17H2,(H,49,56,57)","DTFBEQQOOYQAKH-UHFFFAOYSA-N"
"2532","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(C3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","24.3/50.2","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","186/101","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","654.727","654.259068188","4.83","49","8","8","2","4","146.68","C38H34N6O5","InChI=1S/C38H34N6O5/c1-4-21-17-24-25(38(2,3)34-32(33(24)46)22-9-8-20(19-39)16-26(22)40-34)18-29(21)43-14-12-42(13-15-43)27-7-5-6-23-31(27)37(49)44(36(23)48)28-10-11-30(45)41-35(28)47/h5-9,16-18,28,40H,4,10-15H2,1-3H3,(H,41,45,47)","YVMDSBSVEFRUNQ-UHFFFAOYSA-N"
"2533","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","74.4/81.8","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","121/106","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","754.848","754.322731064","4.62","56","8","10","4","9","187.81","C42H42N8O6","InChI=1S/C42H42N8O6/c1-4-24-19-27-28(42(2,3)38-36(37(27)53)25-9-8-23(21-43)18-30(25)46-38)20-32(24)49-16-14-48(15-17-49)22-34(52)45-13-12-44-29-7-5-6-26-35(29)41(56)50(40(26)55)31-10-11-33(51)47-39(31)54/h5-9,18-20,31,44,46H,4,10-17,22H2,1-3H3,(H,45,52)(H,47,51,54)","RKODSCPRYMAXPY-UHFFFAOYSA-N"
"2534","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(CC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","38.3/75.7","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","77/97","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","782.902","782.354031192","5.34","58","8","10","4","11","187.81","C44H46N8O6","InChI=1S/C44H46N8O6/c1-4-26-21-29-30(44(2,3)40-38(39(29)55)27-11-10-25(23-45)20-32(27)48-40)22-34(26)51-18-16-50(17-19-51)24-36(54)47-15-6-5-14-46-31-9-7-8-28-37(31)43(58)52(42(28)57)33-12-13-35(53)49-41(33)56/h7-11,20-22,33,46,48H,4-6,12-19,24H2,1-3H3,(H,47,54)(H,49,53,56)","CLQXJOQUTRXAJD-UHFFFAOYSA-N"
"2535","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCN(CC(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","51.3/75.8","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","116/114","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","810.956","810.38533132","6.05","60","8","10","4","13","187.81","C46H50N8O6","InChI=1S/C46H50N8O6/c1-4-28-23-31-32(46(2,3)42-40(41(31)57)29-13-12-27(25-47)22-34(29)50-42)24-36(28)53-20-18-52(19-21-53)26-38(56)49-17-8-6-5-7-16-48-33-11-9-10-30-39(33)45(60)54(44(30)59)35-14-15-37(55)51-43(35)58/h9-13,22-24,35,48,50H,4-8,14-21,26H2,1-3H3,(H,49,56)(H,51,55,58)","BGYJVKQWMFAWEA-UHFFFAOYSA-N"
"2536","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(C4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","0/50.6","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","612/640","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","737.861","737.332567476","5.42","55","9","9","2","5","149.92","C43H43N7O5","InChI=1S/C43H43N7O5/c1-4-25-21-29-30(43(2,3)39-37(38(29)52)27-9-8-24(23-44)20-31(27)45-39)22-34(25)48-14-12-26(13-15-48)47-16-18-49(19-17-47)32-7-5-6-28-36(32)42(55)50(41(28)54)33-10-11-35(51)46-40(33)53/h5-9,20-22,26,33,45H,4,10-19H2,1-3H3,(H,46,51,53)","IAUCKZOLLOTUCZ-UHFFFAOYSA-N"
"2537","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CC(=O)NCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","47.8/91","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","121/111","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","837.982","837.396230352","5.21","62","9","11","4","10","191.05","C47H51N9O6","InChI=1S/C47H51N9O6/c1-4-28-23-32-33(47(2,3)43-41(42(32)59)30-9-8-27(25-48)22-35(30)51-43)24-37(28)55-16-12-29(13-17-55)54-20-18-53(19-21-54)26-39(58)50-15-14-49-34-7-5-6-31-40(34)46(62)56(45(31)61)36-10-11-38(57)52-44(36)60/h5-9,22-24,29,36,49,51H,4,10-21,26H2,1-3H3,(H,50,58)(H,52,57,60)","VZMZARQMQAUZAY-UHFFFAOYSA-N"
"2538","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CC(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","49.9/87","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","96/119","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","866.036","865.42753048","5.93","64","9","11","4","12","191.05","C49H55N9O6","InChI=1S/C49H55N9O6/c1-4-30-25-34-35(49(2,3)45-43(44(34)61)32-11-10-29(27-50)24-37(32)53-45)26-39(30)57-18-14-31(15-19-57)56-22-20-55(21-23-56)28-41(60)52-17-6-5-16-51-36-9-7-8-33-42(36)48(64)58(47(33)63)38-12-13-40(59)54-46(38)62/h7-11,24-26,31,38,51,53H,4-6,12-23,28H2,1-3H3,(H,52,60)(H,54,59,62)","NEPFHFUEULTHSK-UHFFFAOYSA-N"
"2539","Q9UM73","ALK","CRBN","","","CCC1=CC2=C(C=C1N1CCC(N3CCN(CC(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC1)C(C)(C)C1=C(C2=O)C2=CC=C(C#N)C=C2[NH]1","","","","24.5/77.3","% ALK degradation in H3122 cells after 16 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","118/119","Inhibit proliferation of H3122/Karpas 299 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c00270","894.09","893.458830608","6.64","66","9","11","4","14","191.05","C51H59N9O6","InChI=1S/C51H59N9O6/c1-4-32-27-36-37(51(2,3)47-45(46(36)63)34-13-12-31(29-52)26-39(34)55-47)28-41(32)59-20-16-33(17-21-59)58-24-22-57(23-25-58)30-43(62)54-19-8-6-5-7-18-53-38-11-9-10-35-44(38)50(66)60(49(35)65)40-14-15-42(61)56-48(40)64/h9-13,26-28,33,40,53,55H,4-8,14-25,30H2,1-3H3,(H,54,62)(H,56,61,64)","XGKYUMNEOGWSOG-UHFFFAOYSA-N"
"2540","O60760","HPGDS","CRBN","","PROTAC(H-PGDS)-3","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCC(=O)N4CCN(C(=O)C5CCN(C6=CC=C(NC(=O)C7=CN=C(OC8=CC=CC=C8)N=C7)C=C6)CC5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01206","990.084","989.428318328","2.03","72","8","16","3","23","240.47","C51H59N9O12","InChI=1S/C51H59N9O12/c61-43-14-13-42(47(64)56-43)60-49(66)40-7-4-8-41(45(40)50(60)67)52-18-26-69-28-30-71-32-31-70-29-27-68-25-17-44(62)58-21-23-59(24-22-58)48(65)35-15-19-57(20-16-35)38-11-9-37(10-12-38)55-46(63)36-33-53-51(54-34-36)72-39-5-2-1-3-6-39/h1-12,33-35,42,52H,13-32H2,(H,55,63)(H,56,61,64)","FHLKQXXAIFVNFQ-UHFFFAOYSA-N"
"2541","O60760","HPGDS","CRBN","","PROTAC(H-PGDS)-4","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCC(=O)N4CCN(C(=O)C5CCN(C6=CC=C(NC(=O)C7=CN=C(OC8=CC=CC=C8)N=C7)C=C6)CC5)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01206","946.031","945.40210358","2.17","69","8","15","3","20","231.24","C49H55N9O11","InChI=1S/C49H55N9O11/c59-41-14-13-40(45(62)54-41)58-47(64)38-7-4-8-39(43(38)48(58)65)50-18-26-67-28-30-68-29-27-66-25-17-42(60)56-21-23-57(24-22-56)46(63)33-15-19-55(20-16-33)36-11-9-35(10-12-36)53-44(61)34-31-51-49(52-32-34)69-37-5-2-1-3-6-37/h1-12,31-33,40,50H,13-30H2,(H,53,61)(H,54,59,62)","QERPOXSNCJAEEU-UHFFFAOYSA-N"
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"2604","P31751","AKT2","CRBN","","","CCN1C(C2=NON=C2N)=NC2=C(C#CC(C)(C)O)N=CC(OCCCNCCCC(=O)NCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01476","853.982","853.42350772","2.43","62","6","16","6","22","261.82","C43H55N11O8","InChI=1S/C43H55N11O8/c1-4-53-37-31(26-48-29(19-20-43(2,3)60)35(37)50-39(53)36-38(44)52-62-51-36)61-25-13-22-45-21-12-16-32(55)47-24-10-8-6-5-7-9-23-46-28-15-11-14-27-34(28)42(59)54(41(27)58)30-17-18-33(56)49-40(30)57/h11,14-15,26,30,45-46,60H,4-10,12-13,16-18,21-25H2,1-3H3,(H2,44,52)(H,47,55)(H,49,56,57)","YILKVWLHVBIWFY-UHFFFAOYSA-N"
"2604","Q9Y243","AKT3","CRBN","","","CCN1C(C2=NON=C2N)=NC2=C(C#CC(C)(C)O)N=CC(OCCCNCCCC(=O)NCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C21","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01476","853.982","853.42350772","2.43","62","6","16","6","22","261.82","C43H55N11O8","InChI=1S/C43H55N11O8/c1-4-53-37-31(26-48-29(19-20-43(2,3)60)35(37)50-39(53)36-38(44)52-62-51-36)61-25-13-22-45-21-12-16-32(55)47-24-10-8-6-5-7-9-23-46-28-15-11-14-27-34(28)42(59)54(41(27)58)30-17-18-33(56)49-40(30)57/h11,14-15,26,30,45-46,60H,4-10,12-13,16-18,21-25H2,1-3H3,(H2,44,52)(H,47,55)(H,49,56,57)","YILKVWLHVBIWFY-UHFFFAOYSA-N"
"2605","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2760","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1126.443","1125.59461287","5.23","81","7","16","5","25","222.73","C60H79N13O7S","InChI=1S/C60H79N13O7S/c1-39-55(81-38-63-39)41-23-21-40(22-24-41)35-62-57(78)50-32-42(74)36-73(50)58(79)56(60(2,3)4)67-53(76)18-14-20-54(77)71(9)31-29-69(7)27-15-19-52(75)64-46-33-47(51(80-11)34-49(46)70(8)30-28-68(5)6)66-59-61-26-25-45(65-59)44-37-72(10)48-17-13-12-16-43(44)48/h12-13,15-17,19,21-26,33-34,37-38,42,50,56,74H,14,18,20,27-32,35-36H2,1-11H3,(H,62,78)(H,64,75)(H,67,76)(H,61,65,66)/b19-15+/t42-,50+,56-/m1/s1","NLHHAISQIXLYLK-GYTYBLAQSA-N"
"2605","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","150","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1126.443","1125.59461287","5.23","81","7","16","5","25","222.73","C60H79N13O7S","InChI=1S/C60H79N13O7S/c1-39-55(81-38-63-39)41-23-21-40(22-24-41)35-62-57(78)50-32-42(74)36-73(50)58(79)56(60(2,3)4)67-53(76)18-14-20-54(77)71(9)31-29-69(7)27-15-19-52(75)64-46-33-47(51(80-11)34-49(46)70(8)30-28-68(5)6)66-59-61-26-25-45(65-59)44-37-72(10)48-17-13-12-16-43(44)48/h12-13,15-17,19,21-26,33-34,37-38,42,50,56,74H,14,18,20,27-32,35-36H2,1-11H3,(H,62,78)(H,64,75)(H,67,76)(H,61,65,66)/b19-15+/t42-,50+,56-/m1/s1","NLHHAISQIXLYLK-GYTYBLAQSA-N"
"2606","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1470","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1154.497","1153.625913","6.13","83","7","16","5","27","222.73","C62H83N13O7S","InChI=1S/C62H83N13O7S/c1-41-57(83-40-65-41)43-25-23-42(24-26-43)37-64-59(80)52-34-44(76)38-75(52)60(81)58(62(2,3)4)69-55(78)20-13-12-14-22-56(79)73(9)33-31-71(7)29-17-21-54(77)66-48-35-49(53(82-11)36-51(48)72(8)32-30-70(5)6)68-61-63-28-27-47(67-61)46-39-74(10)50-19-16-15-18-45(46)50/h15-19,21,23-28,35-36,39-40,44,52,58,76H,12-14,20,22,29-34,37-38H2,1-11H3,(H,64,80)(H,66,77)(H,69,78)(H,63,67,68)/b21-17+/t44-,52+,58-/m1/s1","AUDHLQVDQXAEMW-FUPPDTOQSA-N"
"2606","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/25","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","140","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1154.497","1153.625913","6.13","83","7","16","5","27","222.73","C62H83N13O7S","InChI=1S/C62H83N13O7S/c1-41-57(83-40-65-41)43-25-23-42(24-26-43)37-64-59(80)52-34-44(76)38-75(52)60(81)58(62(2,3)4)69-55(78)20-13-12-14-22-56(79)73(9)33-31-71(7)29-17-21-54(77)66-48-35-49(53(82-11)36-51(48)72(8)32-30-70(5)6)68-61-63-28-27-47(67-61)46-39-74(10)50-19-16-15-18-45(46)50/h15-19,21,23-28,35-36,39-40,44,52,58,76H,12-14,20,22,29-34,37-38H2,1-11H3,(H,64,80)(H,66,77)(H,69,78)(H,63,67,68)/b21-17+/t44-,52+,58-/m1/s1","AUDHLQVDQXAEMW-FUPPDTOQSA-N"
"2607","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1690","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1168.524","1167.64156306","6.67","84","7","16","5","28","222.73","C63H85N13O7S","InChI=1S/C63H85N13O7S/c1-42-58(84-41-66-42)44-26-24-43(25-27-44)38-65-60(81)53-35-45(77)39-76(53)61(82)59(63(2,3)4)70-56(79)21-14-12-13-15-23-57(80)74(9)34-32-72(7)30-18-22-55(78)67-49-36-50(54(83-11)37-52(49)73(8)33-31-71(5)6)69-62-64-29-28-48(68-62)47-40-75(10)51-20-17-16-19-46(47)51/h16-20,22,24-29,36-37,40-41,45,53,59,77H,12-15,21,23,30-35,38-39H2,1-11H3,(H,65,81)(H,67,78)(H,70,79)(H,64,68,69)/b22-18+/t45-,53+,59-/m1/s1","BHWDRQOZBAXOIL-YABATYFBSA-N"
"2607","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCN(C)C(=O)CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/24","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","130","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1168.524","1167.64156306","6.67","84","7","16","5","28","222.73","C63H85N13O7S","InChI=1S/C63H85N13O7S/c1-42-58(84-41-66-42)44-26-24-43(25-27-44)38-65-60(81)53-35-45(77)39-76(53)61(82)59(63(2,3)4)70-56(79)21-14-12-13-15-23-57(80)74(9)34-32-72(7)30-18-22-55(78)67-49-36-50(54(83-11)37-52(49)73(8)33-31-71(5)6)69-62-64-29-28-48(68-62)47-40-75(10)51-20-17-16-19-46(47)51/h16-20,22,24-29,36-37,40-41,45,53,59,77H,12-15,21,23,30-35,38-39H2,1-11H3,(H,65,81)(H,67,78)(H,70,79)(H,64,68,69)/b22-18+/t45-,53+,59-/m1/s1","BHWDRQOZBAXOIL-YABATYFBSA-N"
"2608","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","640","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1097.445","1096.60444928","7.59","79","7","15","5","26","202.42","C60H80N12O6S","InChI=1S/C60H80N12O6S/c1-40-55(79-39-63-40)42-25-23-41(24-26-42)36-62-57(76)51-33-43(73)37-72(51)58(77)56(60(2,3)4)67-54(75)21-14-12-11-13-17-29-69(7)30-18-22-53(74)64-47-34-48(52(78-10)35-50(47)70(8)32-31-68(5)6)66-59-61-28-27-46(65-59)45-38-71(9)49-20-16-15-19-44(45)49/h15-16,18-20,22-28,34-35,38-39,43,51,56,73H,11-14,17,21,29-33,36-37H2,1-10H3,(H,62,76)(H,64,74)(H,67,75)(H,61,65,66)/b22-18+/t43-,51+,56-/m1/s1","UOILNJUDFXJYIX-NQQHQXCWSA-N"
"2608","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/25","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","67","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1097.445","1096.60444928","7.59","79","7","15","5","26","202.42","C60H80N12O6S","InChI=1S/C60H80N12O6S/c1-40-55(79-39-63-40)42-25-23-41(24-26-42)36-62-57(76)51-33-43(73)37-72(51)58(77)56(60(2,3)4)67-54(75)21-14-12-11-13-17-29-69(7)30-18-22-53(74)64-47-34-48(52(78-10)35-50(47)70(8)32-31-68(5)6)66-59-61-28-27-46(65-59)45-38-71(9)49-20-16-15-19-44(45)49/h15-16,18-20,22-28,34-35,38-39,43,51,56,73H,11-14,17,21,29-33,36-37H2,1-10H3,(H,62,76)(H,64,74)(H,67,75)(H,61,65,66)/b22-18+/t43-,51+,56-/m1/s1","UOILNJUDFXJYIX-NQQHQXCWSA-N"
"2609","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","985","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1125.499","1124.63574941","8.68","81","7","15","5","28","202.42","C62H84N12O6S","InChI=1S/C62H84N12O6S/c1-42-57(81-41-65-42)44-27-25-43(26-28-44)38-64-59(78)53-35-45(75)39-74(53)60(79)58(62(2,3)4)69-56(77)23-16-14-12-11-13-15-19-31-71(7)32-20-24-55(76)66-49-36-50(54(80-10)37-52(49)72(8)34-33-70(5)6)68-61-63-30-29-48(67-61)47-40-73(9)51-22-18-17-21-46(47)51/h17-18,20-22,24-30,36-37,40-41,45,53,58,75H,11-16,19,23,31-35,38-39H2,1-10H3,(H,64,78)(H,66,76)(H,69,77)(H,63,67,68)/b24-20+/t45-,53+,58-/m1/s1","BDPJWTWTFREFOU-HAZLKTSUSA-N"
"2609","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C=C/CN(C)CCCCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/30","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","61","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1125.499","1124.63574941","8.68","81","7","15","5","28","202.42","C62H84N12O6S","InChI=1S/C62H84N12O6S/c1-42-57(81-41-65-42)44-27-25-43(26-28-44)38-64-59(78)53-35-45(75)39-74(53)60(79)58(62(2,3)4)69-56(77)23-16-14-12-11-13-15-19-31-71(7)32-20-24-55(76)66-49-36-50(54(80-10)37-52(49)72(8)34-33-70(5)6)68-61-63-30-29-48(67-61)47-40-73(9)51-22-18-17-21-46(47)51/h17-18,20-22,24-30,36-37,40-41,45,53,58,75H,11-16,19,23,31-35,38-39H2,1-10H3,(H,64,78)(H,66,76)(H,69,77)(H,63,67,68)/b24-20+/t45-,53+,58-/m1/s1","BDPJWTWTFREFOU-HAZLKTSUSA-N"
"2610","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","760","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1026.322","1025.53094999","7.35","74","7","14","5","23","199.18","C56H71N11O6S","InChI=1S/C56H71N11O6S/c1-10-49(69)60-43-30-44(62-55-57-25-24-42(61-55)41-34-65(8)45-18-15-14-17-40(41)45)48(73-9)31-46(43)66(28-27-64(6)7)26-16-12-11-13-19-50(70)63-52(56(3,4)5)54(72)67-33-39(68)29-47(67)53(71)58-32-37-20-22-38(23-21-37)51-36(2)59-35-74-51/h10,14-15,17-18,20-25,30-31,34-35,39,47,52,68H,1,11-13,16,19,26-29,32-33H2,2-9H3,(H,58,71)(H,60,69)(H,63,70)(H,57,61,62)/t39-,47+,52-/m1/s1","RLLCZBYYTSDTJQ-VHKLOALXSA-N"
"2610","P00533","EGFR e19d","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","28/34","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","75","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1026.322","1025.53094999","7.35","74","7","14","5","23","199.18","C56H71N11O6S","InChI=1S/C56H71N11O6S/c1-10-49(69)60-43-30-44(62-55-57-25-24-42(61-55)41-34-65(8)45-18-15-14-17-40(41)45)48(73-9)31-46(43)66(28-27-64(6)7)26-16-12-11-13-19-50(70)63-52(56(3,4)5)54(72)67-33-39(68)29-47(67)53(71)58-32-37-20-22-38(23-21-37)51-36(2)59-35-74-51/h10,14-15,17-18,20-25,30-31,34-35,39,47,52,68H,1,11-13,16,19,26-29,32-33H2,2-9H3,(H,58,71)(H,60,69)(H,63,70)(H,57,61,62)/t39-,47+,52-/m1/s1","RLLCZBYYTSDTJQ-VHKLOALXSA-N"
"2611","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","800","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1171.48","1170.6048432","6.4","84","7","17","6","31","246.74","C62H82N12O9S","InChI=1S/C62H82N12O9S/c1-10-54(76)67-48-34-49(69-61-64-25-24-47(68-61)46-38-72(8)50-18-15-14-17-45(46)50)53(81-9)35-51(48)73(29-28-71(6)7)27-16-12-11-13-19-55(77)63-26-30-82-31-32-83-39-56(78)70-58(62(3,4)5)60(80)74-37-44(75)33-52(74)59(79)65-36-42-20-22-43(23-21-42)57-41(2)66-40-84-57/h10,14-15,17-18,20-25,34-35,38,40,44,52,58,75H,1,11-13,16,19,26-33,36-37,39H2,2-9H3,(H,63,77)(H,65,79)(H,67,76)(H,70,78)(H,64,68,69)/t44-,52+,58-/m1/s1","ALUNGNVSILUROK-WZWSVSESSA-N"
"2611","P00533","EGFR e19d","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","23/25","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","683","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1171.48","1170.6048432","6.4","84","7","17","6","31","246.74","C62H82N12O9S","InChI=1S/C62H82N12O9S/c1-10-54(76)67-48-34-49(69-61-64-25-24-47(68-61)46-38-72(8)50-18-15-14-17-45(46)50)53(81-9)35-51(48)73(29-28-71(6)7)27-16-12-11-13-19-55(77)63-26-30-82-31-32-83-39-56(78)70-58(62(3,4)5)60(80)74-37-44(75)33-52(74)59(79)65-36-42-20-22-43(23-21-42)57-41(2)66-40-84-57/h10,14-15,17-18,20-25,34-35,38,40,44,52,58,75H,1,11-13,16,19,26-33,36-37,39H2,2-9H3,(H,63,77)(H,65,79)(H,67,76)(H,70,78)(H,64,68,69)/t44-,52+,58-/m1/s1","ALUNGNVSILUROK-WZWSVSESSA-N"
"2612","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)NCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","730","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1153.509","1152.63066403","8.21","83","7","15","6","30","228.28","C63H84N12O7S","InChI=1S/C63H84N12O7S/c1-10-55(77)68-49-36-50(70-62-65-31-29-48(69-62)47-40-73(8)51-22-18-17-21-46(47)51)54(82-9)37-52(49)74(34-33-72(6)7)32-20-14-12-15-23-56(78)64-30-19-13-11-16-24-57(79)71-59(63(3,4)5)61(81)75-39-45(76)35-53(75)60(80)66-38-43-25-27-44(28-26-43)58-42(2)67-41-83-58/h10,17-18,21-22,25-29,31,36-37,40-41,45,53,59,76H,1,11-16,19-20,23-24,30,32-35,38-39H2,2-9H3,(H,64,78)(H,66,80)(H,68,77)(H,71,79)(H,65,69,70)/t45-,53+,59-/m1/s1","UWPKPQXGEGLODQ-BDMCWMSBSA-N"
"2612","P00533","EGFR e19d","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(CCCCCCC(=O)NCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C)CCN(C)C","","","","<20/<20","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","110","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1153.509","1152.63066403","8.21","83","7","15","6","30","228.28","C63H84N12O7S","InChI=1S/C63H84N12O7S/c1-10-55(77)68-49-36-50(70-62-65-31-29-48(69-62)47-40-73(8)51-22-18-17-21-46(47)51)54(82-9)37-52(49)74(34-33-72(6)7)32-20-14-12-15-23-56(78)64-30-19-13-11-16-24-57(79)71-59(63(3,4)5)61(81)75-39-45(76)35-53(75)60(80)66-38-43-25-27-44(28-26-43)58-42(2)67-41-83-58/h10,17-18,21-22,25-29,31,36-37,40-41,45,53,59,76H,1,11-16,19-20,23-24,30,32-35,38-39H2,2-9H3,(H,64,78)(H,66,80)(H,68,77)(H,71,79)(H,65,69,70)/t45-,53+,59-/m1/s1","UWPKPQXGEGLODQ-BDMCWMSBSA-N"
"2613","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","39/59","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","707","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1040.349","1039.54660006","7.89","75","7","14","5","24","199.18","C57H73N11O6S","InChI=1S/C57H73N11O6S/c1-10-50(70)61-44-31-45(63-56-58-26-25-43(62-56)42-35-67(8)46-19-16-15-18-41(42)46)49(74-9)32-47(44)66(7)29-28-65(6)27-17-13-11-12-14-20-51(71)64-53(57(3,4)5)55(73)68-34-40(69)30-48(68)54(72)59-33-38-21-23-39(24-22-38)52-37(2)60-36-75-52/h10,15-16,18-19,21-26,31-32,35-36,40,48,53,69H,1,11-14,17,20,27-30,33-34H2,2-9H3,(H,59,72)(H,61,70)(H,64,71)(H,58,62,63)/t40-,48+,53-/m1/s1","ZSAWNDDMNMQIIJ-KEQUNFJLSA-N"
"2613","P00533","EGFR e19d","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","42/57","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","86","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1040.349","1039.54660006","7.89","75","7","14","5","24","199.18","C57H73N11O6S","InChI=1S/C57H73N11O6S/c1-10-50(70)61-44-31-45(63-56-58-26-25-43(62-56)42-35-67(8)46-19-16-15-18-41(42)46)49(74-9)32-47(44)66(7)29-28-65(6)27-17-13-11-12-14-20-51(71)64-53(57(3,4)5)55(73)68-34-40(69)30-48(68)54(72)59-33-38-21-23-39(24-22-38)52-37(2)60-36-75-52/h10,15-16,18-19,21-26,31-32,35-36,40,48,53,69H,1,11-14,17,20,27-30,33-34H2,2-9H3,(H,59,72)(H,61,70)(H,64,71)(H,58,62,63)/t40-,48+,53-/m1/s1","ZSAWNDDMNMQIIJ-KEQUNFJLSA-N"
"2614","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2370","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1101.345","1100.52659288","4.88","79","7","17","6","26","246.74","C57H72N12O9S","InChI=1S/C57H72N12O9S/c1-10-49(71)62-43-28-44(64-56-59-20-19-42(63-56)41-32-68(8)45-14-12-11-13-40(41)45)48(76-9)29-46(43)67(7)23-22-66(6)33-50(72)58-21-24-77-25-26-78-34-51(73)65-53(57(3,4)5)55(75)69-31-39(70)27-47(69)54(74)60-30-37-15-17-38(18-16-37)52-36(2)61-35-79-52/h10-20,28-29,32,35,39,47,53,70H,1,21-27,30-31,33-34H2,2-9H3,(H,58,72)(H,60,74)(H,62,71)(H,65,73)(H,59,63,64)/t39-,47+,53-/m1/s1","VJOYYKYPRAJJHC-BRBZWKBWSA-N"
"2614","P00533","EGFR e19d","VHL","","","C=CC(=O)NC1=CC(NC2=NC=CC(C3=CN(C)C4=CC=CC=C34)=N2)=C(OC)C=C1N(C)CCN(C)CC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C2=C(C)N=CS2)C=C1)C(C)(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","768","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1101.345","1100.52659288","4.88","79","7","17","6","26","246.74","C57H72N12O9S","InChI=1S/C57H72N12O9S/c1-10-49(71)62-43-28-44(64-56-59-20-19-42(63-56)41-32-68(8)45-14-12-11-13-40(41)45)48(76-9)29-46(43)67(7)23-22-66(6)33-50(72)58-21-24-77-25-26-78-34-51(73)65-53(57(3,4)5)55(75)69-31-39(70)27-47(69)54(74)60-30-37-15-17-38(18-16-37)52-36(2)61-35-79-52/h10-20,28-29,32,35,39,47,53,70H,1,21-27,30-31,33-34H2,2-9H3,(H,58,72)(H,60,74)(H,62,71)(H,65,73)(H,59,63,64)/t39-,47+,53-/m1/s1","VJOYYKYPRAJJHC-BRBZWKBWSA-N"
"2615","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N2CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=C(NC(=O)/C(C#N)=C/C2CC2)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1146.433","1145.56331274","7.72","83","9","16","6","23","252.07","C62H75N13O7S","InChI=1S/C62H75N13O7S/c1-39-56(83-38-67-39)42-20-18-41(19-21-42)34-66-59(80)52-30-44(76)35-75(52)60(81)57(62(2,3)4)71-54(77)15-9-7-8-12-23-64-55(78)37-73-25-27-74(28-26-73)51-32-53(82-6)49(31-48(51)68-58(79)43(33-63)29-40-16-17-40)70-61-65-24-22-47(69-61)46-36-72(5)50-14-11-10-13-45(46)50/h10-11,13-14,18-22,24,29,31-32,36,38,40,44,52,57,76H,7-9,12,15-17,23,25-28,30,34-35,37H2,1-6H3,(H,64,78)(H,66,80)(H,68,79)(H,71,77)(H,65,69,70)/b43-29+/t44-,52+,57-/m1/s1","IYEGDDXKUGKHBL-YIBIMTPWSA-N"
"2615","P00533","EGFR e19d","VHL","","","COC1=CC(N2CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=C(NC(=O)/C(C#N)=C/C2CC2)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1146.433","1145.56331274","7.72","83","9","16","6","23","252.07","C62H75N13O7S","InChI=1S/C62H75N13O7S/c1-39-56(83-38-67-39)42-20-18-41(19-21-42)34-66-59(80)52-30-44(76)35-75(52)60(81)57(62(2,3)4)71-54(77)15-9-7-8-12-23-64-55(78)37-73-25-27-74(28-26-73)51-32-53(82-6)49(31-48(51)68-58(79)43(33-63)29-40-16-17-40)70-61-65-24-22-47(69-61)46-36-72(5)50-14-11-10-13-45(46)50/h10-11,13-14,18-22,24,29,31-32,36,38,40,44,52,57,76H,7-9,12,15-17,23,25-28,30,34-35,37H2,1-6H3,(H,64,78)(H,66,80)(H,68,79)(H,71,77)(H,65,69,70)/b43-29+/t44-,52+,57-/m1/s1","IYEGDDXKUGKHBL-YIBIMTPWSA-N"
"2616","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N2CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=C(NC(=O)/C(C#N)=C/C2=CC=NC=C2)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1183.454","1182.55856171","7.37","86","9","17","6","23","264.96","C64H74N14O7S","InChI=1S/C64H74N14O7S/c1-41-58(86-40-70-41)44-18-16-43(17-19-44)36-69-61(83)54-32-46(79)37-78(54)62(84)59(64(2,3)4)74-56(80)15-9-7-8-12-23-67-57(81)39-76-27-29-77(30-28-76)53-34-55(85-6)51(33-50(53)71-60(82)45(35-65)31-42-20-24-66-25-21-42)73-63-68-26-22-49(72-63)48-38-75(5)52-14-11-10-13-47(48)52/h10-11,13-14,16-22,24-26,31,33-34,38,40,46,54,59,79H,7-9,12,15,23,27-30,32,36-37,39H2,1-6H3,(H,67,81)(H,69,83)(H,71,82)(H,74,80)(H,68,72,73)/b45-31+/t46-,54+,59-/m1/s1","NIJQPCPIFFRGOF-XYOSPYPGSA-N"
"2616","P00533","EGFR e19d","VHL","","","COC1=CC(N2CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=C(NC(=O)/C(C#N)=C/C2=CC=NC=C2)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1183.454","1182.55856171","7.37","86","9","17","6","23","264.96","C64H74N14O7S","InChI=1S/C64H74N14O7S/c1-41-58(86-40-70-41)44-18-16-43(17-19-44)36-69-61(83)54-32-46(79)37-78(54)62(84)59(64(2,3)4)74-56(80)15-9-7-8-12-23-67-57(81)39-76-27-29-77(30-28-76)53-34-55(85-6)51(33-50(53)71-60(82)45(35-65)31-42-20-24-66-25-21-42)73-63-68-26-22-49(72-63)48-38-75(5)52-14-11-10-13-47(48)52/h10-11,13-14,16-22,24-26,31,33-34,38,40,46,54,59,79H,7-9,12,15,23,27-30,32,36-37,39H2,1-6H3,(H,67,81)(H,69,83)(H,71,82)(H,74,80)(H,68,72,73)/b45-31+/t46-,54+,59-/m1/s1","NIJQPCPIFFRGOF-XYOSPYPGSA-N"
"2617","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N2CCN(C)CC2)=C(NC(=O)/C(C#N)=C/C(C)(C)NC(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5794","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1134.422","1133.56331274","6.75","82","8","16","6","21","252.07","C61H75N13O7S","InChI=1S/C61H75N13O7S/c1-38-54(82-37-65-38)40-21-19-39(20-22-40)34-64-57(79)50-29-42(75)35-74(50)58(80)55(60(2,3)4)69-52(76)17-11-10-12-18-53(77)70-61(5,6)32-41(33-62)56(78)66-46-30-47(51(81-9)31-49(46)73-27-25-71(7)26-28-73)68-59-63-24-23-45(67-59)44-36-72(8)48-16-14-13-15-43(44)48/h13-16,19-24,30-32,36-37,42,50,55,75H,10-12,17-18,25-29,34-35H2,1-9H3,(H,64,79)(H,66,78)(H,69,76)(H,70,77)(H,63,67,68)/b41-32+/t42-,50+,55-/m1/s1","QDRZFVWTDVQLLE-SSYYUHPMSA-N"
"2617","P00533","EGFR e19d","VHL","","","COC1=CC(N2CCN(C)CC2)=C(NC(=O)/C(C#N)=C/C(C)(C)NC(=O)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1390","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1134.422","1133.56331274","6.75","82","8","16","6","21","252.07","C61H75N13O7S","InChI=1S/C61H75N13O7S/c1-38-54(82-37-65-38)40-21-19-39(20-22-40)34-64-57(79)50-29-42(75)35-74(50)58(80)55(60(2,3)4)69-52(76)17-11-10-12-18-53(77)70-61(5,6)32-41(33-62)56(78)66-46-30-47(51(81-9)31-49(46)73-27-25-71(7)26-28-73)68-59-63-24-23-45(67-59)44-36-72(8)48-16-14-13-15-43(44)48/h13-16,19-24,30-32,36-37,42,50,55,75H,10-12,17-18,25-29,34-35H2,1-9H3,(H,64,79)(H,66,78)(H,69,76)(H,70,77)(H,63,67,68)/b41-32+/t42-,50+,55-/m1/s1","QDRZFVWTDVQLLE-SSYYUHPMSA-N"
"2618","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C(C#N)=C/C(C)(C)NC(=O)CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2360","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1150.465","1149.59461287","7.52","83","7","16","6","25","252.07","C62H79N13O7S","InChI=1S/C62H79N13O7S/c1-39-55(83-38-66-39)41-24-22-40(23-25-41)35-65-58(80)51-30-43(76)36-75(51)59(81)56(61(2,3)4)70-53(77)20-14-12-13-15-21-54(78)71-62(5,6)33-42(34-63)57(79)67-47-31-48(52(82-11)32-50(47)73(9)29-28-72(7)8)69-60-64-27-26-46(68-60)45-37-74(10)49-19-17-16-18-44(45)49/h16-19,22-27,31-33,37-38,43,51,56,76H,12-15,20-21,28-30,35-36H2,1-11H3,(H,65,80)(H,67,79)(H,70,77)(H,71,78)(H,64,68,69)/b42-33+/t43-,51+,56-/m1/s1","PLSIZPKPMOPGBN-MGAZKENVSA-N"
"2618","P00533","EGFR e19d","VHL","","","COC1=CC(N(C)CCN(C)C)=C(NC(=O)/C(C#N)=C/C(C)(C)NC(=O)CCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1NC1=NC=CC(C2=CN(C)C3=CC=CC=C23)=N1","","","","<20/26","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","544","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1150.465","1149.59461287","7.52","83","7","16","6","25","252.07","C62H79N13O7S","InChI=1S/C62H79N13O7S/c1-39-55(83-38-66-39)41-24-22-40(23-25-41)35-65-58(80)51-30-43(76)36-75(51)59(81)56(61(2,3)4)70-53(77)20-14-12-13-15-21-54(78)71-62(5,6)33-42(34-63)57(79)67-47-31-48(52(82-11)32-50(47)73(9)29-28-72(7)8)69-60-64-27-26-46(68-60)45-37-74(10)49-19-17-16-18-44(45)49/h16-19,22-27,31-33,37-38,43,51,56,76H,12-15,20-21,28-30,35-36H2,1-11H3,(H,65,80)(H,67,79)(H,70,77)(H,71,78)(H,64,68,69)/b42-33+/t43-,51+,56-/m1/s1","PLSIZPKPMOPGBN-MGAZKENVSA-N"
"2619","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","38/79","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","44/2935","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1050.348","1049.54218337","7.56","76","9","15","5","20","206.08","C57H71N13O5S","InChI=1S/C57H71N13O5S/c1-6-49(73)68-27-25-44(35-68)70-52-46(63-56(70)62-41-14-10-9-11-15-41)34-59-55(65-52)61-42-21-23-43(24-22-42)67-30-28-66(29-31-67)26-13-8-7-12-16-48(72)64-51(57(3,4)5)54(75)69-36-45(71)32-47(69)53(74)58-33-39-17-19-40(20-18-39)50-38(2)60-37-76-50/h6,9-11,14-15,17-24,34,37,44-45,47,51,71H,1,7-8,12-13,16,25-33,35-36H2,2-5H3,(H,58,74)(H,62,63)(H,64,72)(H,59,61,65)/t44-,45+,47-,51+/m0/s1","FXWJQZDZCXGXTI-XSCJKQSPSA-N"
"2619","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","65/81","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.66/2935","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1050.348","1049.54218337","7.56","76","9","15","5","20","206.08","C57H71N13O5S","InChI=1S/C57H71N13O5S/c1-6-49(73)68-27-25-44(35-68)70-52-46(63-56(70)62-41-14-10-9-11-15-41)34-59-55(65-52)61-42-21-23-43(24-22-42)67-30-28-66(29-31-67)26-13-8-7-12-16-48(72)64-51(57(3,4)5)54(75)69-36-45(71)32-47(69)53(74)58-33-39-17-19-40(20-18-39)50-38(2)60-37-76-50/h6,9-11,14-15,17-24,34,37,44-45,47,51,71H,1,7-8,12-13,16,25-33,35-36H2,2-5H3,(H,58,74)(H,62,63)(H,64,72)(H,59,61,65)/t44-,45+,47-,51+/m0/s1","FXWJQZDZCXGXTI-XSCJKQSPSA-N"
"2620","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","49/69","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","40/414","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1064.375","1063.55783344","7.91","77","9","15","5","20","206.08","C58H73N13O5S","InChI=1S/C58H73N13O5S/c1-6-50(74)69-28-14-17-45(36-69)71-53-47(64-57(71)63-42-15-10-9-11-16-42)35-60-56(66-53)62-43-23-25-44(26-24-43)68-31-29-67(30-32-68)27-13-8-7-12-18-49(73)65-52(58(3,4)5)55(76)70-37-46(72)33-48(70)54(75)59-34-40-19-21-41(22-20-40)51-39(2)61-38-77-51/h6,9-11,15-16,19-26,35,38,45-46,48,52,72H,1,7-8,12-14,17-18,27-34,36-37H2,2-5H3,(H,59,75)(H,63,64)(H,65,73)(H,60,62,66)/t45-,46+,48-,52+/m0/s1","CSQRGDCIFDELOJ-XBQJXWJCSA-N"
"2620","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","62/70","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.67/414","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1064.375","1063.55783344","7.91","77","9","15","5","20","206.08","C58H73N13O5S","InChI=1S/C58H73N13O5S/c1-6-50(74)69-28-14-17-45(36-69)71-53-47(64-57(71)63-42-15-10-9-11-16-42)35-60-56(66-53)62-43-23-25-44(26-24-43)68-31-29-67(30-32-68)27-13-8-7-12-18-49(73)65-52(58(3,4)5)55(76)70-37-46(72)33-48(70)54(75)59-34-40-19-21-41(22-20-40)51-39(2)61-38-77-51/h6,9-11,15-16,19-26,35,38,45-46,48,52,72H,1,7-8,12-14,17-18,27-34,36-37H2,2-5H3,(H,59,75)(H,63,64)(H,65,73)(H,60,62,66)/t45-,46+,48-,52+/m0/s1","CSQRGDCIFDELOJ-XBQJXWJCSA-N"
"2621","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","47/74","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39/250","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1078.402","1077.5734835","8.45","78","9","15","5","21","206.08","C59H75N13O5S","InChI=1S/C59H75N13O5S/c1-6-51(75)70-29-15-18-46(37-70)72-54-48(65-58(72)64-43-16-11-10-12-17-43)36-61-57(67-54)63-44-24-26-45(27-25-44)69-32-30-68(31-33-69)28-14-9-7-8-13-19-50(74)66-53(59(3,4)5)56(77)71-38-47(73)34-49(71)55(76)60-35-41-20-22-42(23-21-41)52-40(2)62-39-78-52/h6,10-12,16-17,20-27,36,39,46-47,49,53,73H,1,7-9,13-15,18-19,28-35,37-38H2,2-5H3,(H,60,76)(H,64,65)(H,66,74)(H,61,63,67)/t46-,47+,49-,53+/m0/s1","WSSNDQVXHFXMID-APOZONLHSA-N"
"2621","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","69/78","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.55/250","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1078.402","1077.5734835","8.45","78","9","15","5","21","206.08","C59H75N13O5S","InChI=1S/C59H75N13O5S/c1-6-51(75)70-29-15-18-46(37-70)72-54-48(65-58(72)64-43-16-11-10-12-17-43)36-61-57(67-54)63-44-24-26-45(27-25-44)69-32-30-68(31-33-69)28-14-9-7-8-13-19-50(74)66-53(59(3,4)5)56(77)71-38-47(73)34-49(71)55(76)60-35-41-20-22-42(23-21-41)52-40(2)62-39-78-52/h6,10-12,16-17,20-27,36,39,46-47,49,53,73H,1,7-9,13-15,18-19,28-35,37-38H2,2-5H3,(H,60,76)(H,64,65)(H,66,74)(H,61,63,67)/t46-,47+,49-,53+/m0/s1","WSSNDQVXHFXMID-APOZONLHSA-N"
"2622","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","<20/23","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","250/>10000","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1107.4","1106.56364709","6.72","80","9","16","6","21","235.18","C59H74N14O6S","InChI=1S/C59H74N14O6S/c1-6-51(77)71-27-13-16-45(35-71)73-54-47(66-58(73)65-42-14-9-7-10-15-42)34-62-57(68-54)64-43-22-24-44(25-23-43)70-30-28-69(29-31-70)37-50(76)60-26-12-8-11-17-49(75)67-53(59(3,4)5)56(79)72-36-46(74)32-48(72)55(78)61-33-40-18-20-41(21-19-40)52-39(2)63-38-80-52/h6-7,9-10,14-15,18-25,34,38,45-46,48,53,74H,1,8,11-13,16-17,26-33,35-37H2,2-5H3,(H,60,76)(H,61,78)(H,65,66)(H,67,75)(H,62,64,68)/t45-,46+,48-,53+/m0/s1","GKMLWAGLQFDOKQ-BCWDIVJWSA-N"
"2622","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","46/60","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","36.5/>10000","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1107.4","1106.56364709","6.72","80","9","16","6","21","235.18","C59H74N14O6S","InChI=1S/C59H74N14O6S/c1-6-51(77)71-27-13-16-45(35-71)73-54-47(66-58(73)65-42-14-9-7-10-15-42)34-62-57(68-54)64-43-22-24-44(25-23-43)70-30-28-69(29-31-70)37-50(76)60-26-12-8-11-17-49(75)67-53(59(3,4)5)56(79)72-36-46(74)32-48(72)55(78)61-33-40-18-20-41(21-19-40)52-39(2)63-38-80-52/h6-7,9-10,14-15,18-25,34,38,45-46,48,53,74H,1,8,11-13,16-17,26-33,35-37H2,2-5H3,(H,60,76)(H,61,78)(H,65,66)(H,67,75)(H,62,64,68)/t45-,46+,48-,53+/m0/s1","GKMLWAGLQFDOKQ-BCWDIVJWSA-N"
"2623","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","127/>10000","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1121.427","1120.57929715","7.26","81","9","16","6","22","235.18","C60H76N14O6S","InChI=1S/C60H76N14O6S/c1-6-52(78)72-28-14-17-46(36-72)74-55-48(67-59(74)66-43-15-10-9-11-16-43)35-63-58(69-55)65-44-23-25-45(26-24-44)71-31-29-70(30-32-71)38-51(77)61-27-13-8-7-12-18-50(76)68-54(60(3,4)5)57(80)73-37-47(75)33-49(73)56(79)62-34-41-19-21-42(22-20-41)53-40(2)64-39-81-53/h6,9-11,15-16,19-26,35,39,46-47,49,54,75H,1,7-8,12-14,17-18,27-34,36-38H2,2-5H3,(H,61,77)(H,62,79)(H,66,67)(H,68,76)(H,63,65,69)/t46-,47+,49-,54+/m0/s1","IROOQIWNFFCZLN-VEJFJKOFSA-N"
"2623","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","63/77","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.93/>10000","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1121.427","1120.57929715","7.26","81","9","16","6","22","235.18","C60H76N14O6S","InChI=1S/C60H76N14O6S/c1-6-52(78)72-28-14-17-46(36-72)74-55-48(67-59(74)66-43-15-10-9-11-16-43)35-63-58(69-55)65-44-23-25-45(26-24-44)71-31-29-70(30-32-71)38-51(77)61-27-13-8-7-12-18-50(76)68-54(60(3,4)5)57(80)73-37-47(75)33-49(73)56(79)62-34-41-19-21-42(22-20-41)53-40(2)64-39-81-53/h6,9-11,15-16,19-26,35,39,46-47,49,54,75H,1,7-8,12-14,17-18,27-34,36-38H2,2-5H3,(H,61,77)(H,62,79)(H,66,67)(H,68,76)(H,63,65,69)/t46-,47+,49-,54+/m0/s1","IROOQIWNFFCZLN-VEJFJKOFSA-N"
"2624","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","282/>10000","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1139.398","1138.55347633","5.45","82","9","18","6","23","253.64","C59H74N14O8S","InChI=1S/C59H74N14O8S/c1-6-51(77)71-23-10-13-45(34-71)73-54-47(66-58(73)65-42-11-8-7-9-12-42)33-62-57(68-54)64-43-18-20-44(21-19-43)70-26-24-69(25-27-70)36-49(75)60-22-28-80-29-30-81-37-50(76)67-53(59(3,4)5)56(79)72-35-46(74)31-48(72)55(78)61-32-40-14-16-41(17-15-40)52-39(2)63-38-82-52/h6-9,11-12,14-21,33,38,45-46,48,53,74H,1,10,13,22-32,34-37H2,2-5H3,(H,60,75)(H,61,78)(H,65,66)(H,67,76)(H,62,64,68)/t45-,46+,48-,53+/m0/s1","HTDTVBXASZKIHM-BCWDIVJWSA-N"
"2624","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCOCCOCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCC6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","50/57","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","59.61/>10000","Inhibit proliferation of HCC827 (EGFR del19)/HCT116 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1139.398","1138.55347633","5.45","82","9","18","6","23","253.64","C59H74N14O8S","InChI=1S/C59H74N14O8S/c1-6-51(77)71-23-10-13-45(34-71)73-54-47(66-58(73)65-42-11-8-7-9-12-42)33-62-57(68-54)64-43-18-20-44(21-19-43)70-26-24-69(25-27-70)36-49(75)60-22-28-80-29-30-81-37-50(76)67-53(59(3,4)5)56(79)72-35-46(74)31-48(72)55(78)61-32-40-14-16-41(17-15-40)52-39(2)63-38-82-52/h6-9,11-12,14-21,33,38,45-46,48,53,74H,1,10,13,22-32,34-37H2,2-5H3,(H,60,75)(H,61,78)(H,65,66)(H,67,76)(H,62,64,68)/t45-,46+,48-,53+/m0/s1","HTDTVBXASZKIHM-BCWDIVJWSA-N"
"2625","P00533","EGFR L858R/T790M","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","1.56","86","Degradation of EGFR L858R/T790M in H1975 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32/298/105","Inhibit proliferation of H1975 (EGFR L858R/T790M)/HCT116/SU-DHL-6 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1092.429","1091.58913356","8.86","79","9","15","5","21","206.08","C60H77N13O5S","InChI=1S/C60H77N13O5S/c1-7-52(76)71-30-16-19-47(37-71)73-55-49(66-59(73)65-44-17-12-11-13-18-44)36-61-58(68-55)64-45-25-27-46(28-26-45)70-33-31-69(32-34-70)29-15-10-8-9-14-20-51(75)67-54(60(4,5)6)57(78)72-38-48(74)35-50(72)56(77)63-40(2)42-21-23-43(24-22-42)53-41(3)62-39-79-53/h7,11-13,17-18,21-28,36,39-40,47-48,50,54,74H,1,8-10,14-16,19-20,29-35,37-38H2,2-6H3,(H,63,77)(H,65,66)(H,67,75)(H,61,64,68)/t40-,47-,48+,50-,54+/m0/s1","RYXQXEGTLNBKEC-DKQRTKIFSA-N"
"2625","P00533","EGFR e19d","VHL","","","C=CC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","0.49","82","Degradation of EGFR e19d in HCC827 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.6/298/105","Inhibit proliferation of HCC827 (EGFR del19)/HCT116/SU-DHL-6 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1092.429","1091.58913356","8.86","79","9","15","5","21","206.08","C60H77N13O5S","InChI=1S/C60H77N13O5S/c1-7-52(76)71-30-16-19-47(37-71)73-55-49(66-59(73)65-44-17-12-11-13-18-44)36-61-58(68-55)64-45-25-27-46(28-26-45)70-33-31-69(32-34-70)29-15-10-8-9-14-20-51(75)67-54(60(4,5)6)57(78)72-38-48(74)35-50(72)56(77)63-40(2)42-21-23-43(24-22-42)53-41(3)62-39-79-53/h7,11-13,17-18,21-28,36,39-40,47-48,50,54,74H,1,8-10,14-16,19-20,29-35,37-38H2,2-6H3,(H,63,77)(H,65,66)(H,67,75)(H,61,64,68)/t40-,47-,48+,50-,54+/m0/s1","RYXQXEGTLNBKEC-DKQRTKIFSA-N"
"2626","P00533","EGFR L858R/T790M","VHL","","","CCC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","<20/<20","% EGFR L858R/T790M degradation in H1975 cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2901","Inhibit proliferation of H1975 (EGFR L858R/T790M) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1094.445","1093.60478363","8.74","79","9","15","5","21","206.08","C60H79N13O5S","InChI=1S/C60H79N13O5S/c1-7-52(76)71-30-16-19-47(37-71)73-55-49(66-59(73)65-44-17-12-11-13-18-44)36-61-58(68-55)64-45-25-27-46(28-26-45)70-33-31-69(32-34-70)29-15-10-8-9-14-20-51(75)67-54(60(4,5)6)57(78)72-38-48(74)35-50(72)56(77)63-40(2)42-21-23-43(24-22-42)53-41(3)62-39-79-53/h11-13,17-18,21-28,36,39-40,47-48,50,54,74H,7-10,14-16,19-20,29-35,37-38H2,1-6H3,(H,63,77)(H,65,66)(H,67,75)(H,61,64,68)/t40-,47-,48+,50-,54+/m0/s1","NEBQLCJXQCQWAT-DKQRTKIFSA-N"
"2626","P00533","EGFR e19d","VHL","","","CCC(=O)N1CCC[C@H](N2C(NC3=CC=CC=C3)=NC3=CN=C(NC4=CC=C(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)C=C4)N=C32)C1","","","","69/72","% EGFR del19 degradation in HCC827 cells after 24 h treatment at 3/30 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.39","Inhibit proliferation of HCC827 (EGFR del19) cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01827","1094.445","1093.60478363","8.74","79","9","15","5","21","206.08","C60H79N13O5S","InChI=1S/C60H79N13O5S/c1-7-52(76)71-30-16-19-47(37-71)73-55-49(66-59(73)65-44-17-12-11-13-18-44)36-61-58(68-55)64-45-25-27-46(28-26-45)70-33-31-69(32-34-70)29-15-10-8-9-14-20-51(75)67-54(60(4,5)6)57(78)72-38-48(74)35-50(72)56(77)63-40(2)42-21-23-43(24-22-42)53-41(3)62-39-79-53/h11-13,17-18,21-28,36,39-40,47-48,50,54,74H,7-10,14-16,19-20,29-35,37-38H2,1-6H3,(H,63,77)(H,65,66)(H,67,75)(H,61,64,68)/t40-,47-,48+,50-,54+/m0/s1","NEBQLCJXQCQWAT-DKQRTKIFSA-N"
"2627","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","5.8/30.4","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1009.738","1008.49747762","7.61","71","9","12","4","16","151.2","C54H70ClFN10O4S","InChI=1S/C54H70ClFN10O4S/c1-33-21-37(22-34(2)46(33)56)26-66-43-24-40(55)23-42(47(43)61-52(66)64-30-54(31-64)28-57-29-54)63-19-17-62(18-20-63)16-10-8-9-11-45(68)60-49(53(5,6)7)51(70)65-27-41(67)25-44(65)50(69)59-35(3)38-12-14-39(15-13-38)48-36(4)58-32-71-48/h12-15,21-24,32,35,41,44,49,57,67H,8-11,16-20,25-31H2,1-7H3,(H,59,69)(H,60,68)/t35-,41+,44-,49+/m0/s1","KRTXNKFNVDUMFW-LGMUQQJESA-N"
"2628","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","216.4","","Degradation of SOS1 in NCI-H358 cells after 24 h treatment","30.7/79.9","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1023.765","1022.51312768","8.15","72","9","12","4","17","151.2","C55H72ClFN10O4S","InChI=1S/C55H72ClFN10O4S/c1-34-22-38(23-35(2)47(34)57)27-67-44-25-41(56)24-43(48(44)62-53(67)65-31-55(32-65)29-58-30-55)64-20-18-63(19-21-64)17-11-9-8-10-12-46(69)61-50(54(5,6)7)52(71)66-28-42(68)26-45(66)51(70)60-36(3)39-13-15-40(16-14-39)49-37(4)59-33-72-49/h13-16,22-25,33,36,42,45,50,58,68H,8-12,17-21,26-32H2,1-7H3,(H,60,70)(H,61,69)/t36-,42+,45-,50+/m0/s1","RWXRMOUTGNDVRG-UEFBMBKASA-N"
"2629","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","150.3","","Degradation of SOS1 in NCI-H358 cells after 24 h treatment","27.6/80.9","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1037.792","1036.52877775","8.69","73","9","12","4","18","151.2","C56H74ClFN10O4S","InChI=1S/C56H74ClFN10O4S/c1-35-23-39(24-36(2)48(35)58)28-68-45-26-42(57)25-44(49(45)63-54(68)66-32-56(33-66)30-59-31-56)65-21-19-64(20-22-65)18-12-10-8-9-11-13-47(70)62-51(55(5,6)7)53(72)67-29-43(69)27-46(67)52(71)61-37(3)40-14-16-41(17-15-40)50-38(4)60-34-73-50/h14-17,23-26,34,37,43,46,51,59,69H,8-13,18-22,27-33H2,1-7H3,(H,61,71)(H,62,70)/t37-,43+,46-,51+/m0/s1","BQACEOFNSGFSPA-FIOHTOFWSA-N"
"2630","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","98.4/255/119","","Degradation of SOS1 in NCI-H358/MIA PaCa2/AsPC-1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","56","SPR","","","","","","","","","","","","","","","3.7","Kd between VHL and the complex of protac and SOS1 was tested by SPR","","","","","","","","","","","525/218/307","Inhibit growth of NCI-H358/MIA PaCa2/AsPC-1 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1051.819","1050.54442781","9.23","74","9","12","4","19","151.2","C57H76ClFN10O4S","InChI=1S/C57H76ClFN10O4S/c1-36-24-40(25-37(2)49(36)59)29-69-46-27-43(58)26-45(50(46)64-55(69)67-33-57(34-67)31-60-32-57)66-22-20-65(21-23-66)19-13-11-9-8-10-12-14-48(71)63-52(56(5,6)7)54(73)68-30-44(70)28-47(68)53(72)62-38(3)41-15-17-42(18-16-41)51-39(4)61-35-74-51/h15-18,24-27,35,38,44,47,52,60,70H,8-14,19-23,28-34H2,1-7H3,(H,62,72)(H,63,71)/t38-,44+,47-,52+/m0/s1","AZBRWXRYNYEDKG-VWELVXIZSA-N"
"2630","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","104/125/22","","Degradation of SOS1 in SK-LU-1/SW620/A549 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","115/199/232","Inhibit growth of SK-LU-1/SW620/A549 cells","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1051.819","1050.54442781","9.23","74","9","12","4","19","151.2","C57H76ClFN10O4S","InChI=1S/C57H76ClFN10O4S/c1-36-24-40(25-37(2)49(36)59)29-69-46-27-43(58)26-45(50(46)64-55(69)67-33-57(34-67)31-60-32-57)66-22-20-65(21-23-66)19-13-11-9-8-10-12-14-48(71)63-52(56(5,6)7)54(73)68-30-44(70)28-47(68)53(72)62-38(3)41-15-17-42(18-16-41)51-39(4)61-35-74-51/h15-18,24-27,35,38,44,47,52,60,70H,8-14,19-23,28-34H2,1-7H3,(H,62,72)(H,63,71)/t38-,44+,47-,52+/m0/s1","AZBRWXRYNYEDKG-VWELVXIZSA-N"
"2631","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","182.1","","Degradation of SOS1 in NCI-H358 cells after 24 h treatment","38.5/82","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1065.846","1064.56007788","9.77","75","9","12","4","20","151.2","C58H78ClFN10O4S","InChI=1S/C58H78ClFN10O4S/c1-37-25-41(26-38(2)50(37)60)30-70-47-28-44(59)27-46(51(47)65-56(70)68-34-58(35-68)32-61-33-58)67-23-21-66(22-24-67)20-14-12-10-8-9-11-13-15-49(72)64-53(57(5,6)7)55(74)69-31-45(71)29-48(69)54(73)63-39(3)42-16-18-43(19-17-42)52-40(4)62-36-75-52/h16-19,25-28,36,39,45,48,53,61,71H,8-15,20-24,29-35H2,1-7H3,(H,63,73)(H,64,72)/t39-,45+,48-,53+/m0/s1","BKHFNIAHQPHQNG-NFPWTNQKSA-N"
"2632","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","31.7/63.2","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1079.873","1078.57572794","10.31","76","9","12","4","21","151.2","C59H80ClFN10O4S","InChI=1S/C59H80ClFN10O4S/c1-38-26-42(27-39(2)51(38)61)31-71-48-29-45(60)28-47(52(48)66-57(71)69-35-59(36-69)33-62-34-59)68-24-22-67(23-25-68)21-15-13-11-9-8-10-12-14-16-50(73)65-54(58(5,6)7)56(75)70-32-46(72)30-49(70)55(74)64-40(3)43-17-19-44(20-18-43)53-41(4)63-37-76-53/h17-20,26-29,37,40,46,49,54,62,72H,8-16,21-25,30-36H2,1-7H3,(H,64,74)(H,65,73)/t40-,46+,49-,54+/m0/s1","YIHJSSOOZVRPGE-KKQPRNPJSA-N"
"2633","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","33/49","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1093.9","1092.591378","10.86","77","9","12","4","22","151.2","C60H82ClFN10O4S","InChI=1S/C60H82ClFN10O4S/c1-39-27-43(28-40(2)52(39)62)32-72-49-30-46(61)29-48(53(49)67-58(72)70-36-60(37-70)34-63-35-60)69-25-23-68(24-26-69)22-16-14-12-10-8-9-11-13-15-17-51(74)66-55(59(5,6)7)57(76)71-33-47(73)31-50(71)56(75)65-41(3)44-18-20-45(21-19-44)54-42(4)64-38-77-54/h18-21,27-30,38,41,47,50,55,63,73H,8-17,22-26,31-37H2,1-7H3,(H,65,75)(H,66,74)/t41-,47+,50-,55+/m0/s1","KMPZNMUJYMSUSI-LJBHZTHOSA-N"
"2634","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","23.3/24.4","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1041.736","1040.48730686","6.34","73","9","14","4","18","169.66","C54H70ClFN10O6S","InChI=1S/C54H70ClFN10O6S/c1-33-20-37(21-34(2)46(33)56)25-66-43-23-40(55)22-42(47(43)61-52(66)64-30-54(31-64)28-57-29-54)63-14-12-62(13-15-63)16-17-71-18-19-72-27-45(68)60-49(53(5,6)7)51(70)65-26-41(67)24-44(65)50(69)59-35(3)38-8-10-39(11-9-38)48-36(4)58-32-73-48/h8-11,20-23,32,35,41,44,49,57,67H,12-19,24-31H2,1-7H3,(H,59,69)(H,60,68)/t35-,41+,44-,49+/m0/s1","OEOJRBFVJBZNNH-LGMUQQJESA-N"
"2635","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","4.4/14","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1055.763","1054.50295692","6.24","74","9","14","4","19","169.66","C55H72ClFN10O6S","InChI=1S/C55H72ClFN10O6S/c1-34-22-38(23-35(2)47(34)57)27-67-44-25-41(56)24-43(48(44)62-53(67)65-31-55(32-65)29-58-30-55)64-15-13-63(14-16-64)17-19-73-21-20-72-18-12-46(69)61-50(54(5,6)7)52(71)66-28-42(68)26-45(66)51(70)60-36(3)39-8-10-40(11-9-39)49-37(4)59-33-74-49/h8-11,22-25,33,36,42,45,50,58,68H,12-21,26-32H2,1-7H3,(H,60,70)(H,61,69)/t36-,42+,45-,50+/m0/s1","HNWMZIJESIXUPN-UEFBMBKASA-N"
"2636","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","15.4/36.6","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1099.816","1098.52917167","6.09","77","9","15","4","22","178.89","C57H76ClFN10O7S","InChI=1S/C57H76ClFN10O7S/c1-36-24-40(25-37(2)49(36)59)29-69-46-27-43(58)26-45(50(46)64-55(69)67-33-57(34-67)31-60-32-57)66-15-13-65(14-16-66)17-19-75-21-23-76-22-20-74-18-12-48(71)63-52(56(5,6)7)54(73)68-30-44(70)28-47(68)53(72)62-38(3)41-8-10-42(11-9-41)51-39(4)61-35-77-51/h8-11,24-27,35,38,44,47,52,60,70H,12-23,28-34H2,1-7H3,(H,62,72)(H,63,71)/t38-,44+,47-,52+/m0/s1","JVXPJYDGYNFLML-VWELVXIZSA-N"
"2637","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCC(=O)NCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","0/18.3","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1052.763","1051.50329127","6.14","74","9","13","5","17","180.3","C55H71ClFN11O5S","InChI=1S/C55H71ClFN11O5S/c1-33-21-37(22-34(2)47(33)57)26-68-43-24-40(56)23-42(48(43)63-53(68)66-30-55(31-66)28-58-29-55)65-19-17-64(18-20-65)16-14-45(70)59-15-8-9-46(71)62-50(54(5,6)7)52(73)67-27-41(69)25-44(67)51(72)61-35(3)38-10-12-39(13-11-38)49-36(4)60-32-74-49/h10-13,21-24,32,35,41,44,50,58,69H,8-9,14-20,25-31H2,1-7H3,(H,59,70)(H,61,72)(H,62,71)/t35-,41+,44-,50+/m0/s1","KEAIJOOOCCVKLN-ZAAGDDRPSA-N"
"2638","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCC(=O)NCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","8/12.7","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1066.79","1065.51894134","6.5","75","9","13","5","18","180.3","C56H73ClFN11O5S","InChI=1S/C56H73ClFN11O5S/c1-34-22-38(23-35(2)48(34)58)27-69-44-25-41(57)24-43(49(44)64-54(69)67-31-56(32-67)29-59-30-56)66-20-18-65(19-21-66)17-9-11-46(71)60-16-8-10-47(72)63-51(55(5,6)7)53(74)68-28-42(70)26-45(68)52(73)62-36(3)39-12-14-40(15-13-39)50-37(4)61-33-75-50/h12-15,22-25,33,36,42,45,51,59,70H,8-11,16-21,26-32H2,1-7H3,(H,60,71)(H,62,73)(H,63,72)/t36-,42+,45-,51+/m0/s1","GGQNUIQRAOZHGV-PMAWTLHNSA-N"
"2639","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCC(=O)NCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","3.2/0","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1080.817","1079.5345914","6.85","76","9","13","5","19","180.3","C57H75ClFN11O5S","InChI=1S/C57H75ClFN11O5S/c1-35-23-39(24-36(2)49(35)59)28-70-45-26-42(58)25-44(50(45)65-55(70)68-32-57(33-68)30-60-31-57)67-21-19-66(20-22-67)18-9-8-11-47(72)61-17-10-12-48(73)64-52(56(5,6)7)54(75)69-29-43(71)27-46(69)53(74)63-37(3)40-13-15-41(16-14-40)51-38(4)62-34-76-51/h13-16,23-26,34,37,43,46,52,60,71H,8-12,17-22,27-33H2,1-7H3,(H,61,72)(H,63,74)(H,64,73)/t37-,43+,46-,52+/m0/s1","AIYOQVDTDVIWSY-IJDAKYKUSA-N"
"2640","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CC5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","13/43.3","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1050.791","1049.52402672","7.41","74","10","13","4","14","154.44","C56H73ClFN11O4S","InChI=1S/C56H73ClFN11O4S/c1-34-20-39(21-35(2)48(34)58)26-69-45-23-42(57)22-44(49(45)63-54(69)67-31-56(32-67)29-59-30-56)66-18-16-65(17-19-66)25-38-12-14-64(15-13-38)28-47(71)62-51(55(5,6)7)53(73)68-27-43(70)24-46(68)52(72)61-36(3)40-8-10-41(11-9-40)50-37(4)60-33-74-50/h8-11,20-23,33,36,38,43,46,51,59,70H,12-19,24-32H2,1-7H3,(H,61,72)(H,62,71)/t36-,43+,46-,51+/m0/s1","QIUKMSWZQUPCKX-XZHQIWKUSA-N"
"2641","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CC5CCN(CCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","18.1/9.4","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1064.818","1063.53967678","7.32","75","10","13","4","15","154.44","C57H75ClFN11O4S","InChI=1S/C57H75ClFN11O4S/c1-35-22-40(23-36(2)49(35)59)28-70-46-25-43(58)24-45(50(46)64-55(70)68-32-57(33-68)30-60-31-57)67-20-18-66(19-21-67)27-39-12-15-65(16-13-39)17-14-48(72)63-52(56(5,6)7)54(74)69-29-44(71)26-47(69)53(73)62-37(3)41-8-10-42(11-9-41)51-38(4)61-34-75-51/h8-11,22-25,34,37,39,44,47,52,60,71H,12-21,26-33H2,1-7H3,(H,62,73)(H,63,72)/t37-,44+,47-,52+/m0/s1","VGSNFIXQGOYMDO-XDORKCNKSA-N"
"2642","Q07889","SOS1","VHL","","","CC1=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CC5CCN(CCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)C(C)(C)C)CC5)CC4)C=C(Cl)C=C32)=CC(C)=C1F","","","","7/11.2","% SOS1 degradation in NCI-H358 cells after 24 h treatment at 100/1000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.jmedchem.1c01774","1078.845","1077.55532684","7.67","76","10","13","4","16","154.44","C58H77ClFN11O4S","InChI=1S/C58H77ClFN11O4S/c1-36-23-41(24-37(2)50(36)60)29-71-47-26-44(59)25-46(51(47)65-56(71)69-33-58(34-69)31-61-32-58)68-21-19-67(20-22-68)28-40-14-17-66(18-15-40)16-8-9-49(73)64-53(57(5,6)7)55(75)70-30-45(72)27-48(70)54(74)63-38(3)42-10-12-43(13-11-42)52-39(4)62-35-76-52/h10-13,23-26,35,38,40,45,48,53,61,72H,8-9,14-22,27-34H2,1-7H3,(H,63,74)(H,64,73)/t38-,45+,48-,53+/m0/s1","KGZDQGZDFMGWIY-CBWPMGTASA-N"
"2643","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","471.8/84.94","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","33.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","686.725","686.248897428","4.1","51","7","9","4","11","171.7","C38H34N6O7","InChI=1S/C38H34N6O7/c1-43-21-26(23-12-5-6-15-30(23)51-22-10-3-2-4-11-22)25-20-28(41-33(25)38(43)50)34(46)40-19-8-7-18-39-27-14-9-13-24-32(27)37(49)44(36(24)48)29-16-17-31(45)42-35(29)47/h2-6,9-15,20-21,29,39,41H,7-8,16-19H2,1H3,(H,40,46)(H,42,45,47)","RDNFGFLAUBFYEP-UHFFFAOYSA-N"
"2643","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","33.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","686.725","686.248897428","4.1","51","7","9","4","11","171.7","C38H34N6O7","InChI=1S/C38H34N6O7/c1-43-21-26(23-12-5-6-15-30(23)51-22-10-3-2-4-11-22)25-20-28(41-33(25)38(43)50)34(46)40-19-8-7-18-39-27-14-9-13-24-32(27)37(49)44(36(24)48)29-16-17-31(45)42-35(29)47/h2-6,9-15,20-21,29,39,41H,7-8,16-19H2,1H3,(H,40,46)(H,42,45,47)","RDNFGFLAUBFYEP-UHFFFAOYSA-N"
"2643","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","33.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","686.725","686.248897428","4.1","51","7","9","4","11","171.7","C38H34N6O7","InChI=1S/C38H34N6O7/c1-43-21-26(23-12-5-6-15-30(23)51-22-10-3-2-4-11-22)25-20-28(41-33(25)38(43)50)34(46)40-19-8-7-18-39-27-14-9-13-24-32(27)37(49)44(36(24)48)29-16-17-31(45)42-35(29)47/h2-6,9-15,20-21,29,39,41H,7-8,16-19H2,1H3,(H,40,46)(H,42,45,47)","RDNFGFLAUBFYEP-UHFFFAOYSA-N"
"2644","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","440.7/39.37","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.3","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","714.779","714.280197556","4.82","53","7","9","4","13","171.7","C40H38N6O7","InChI=1S/C40H38N6O7/c1-45-23-28(25-14-7-8-17-32(25)53-24-12-5-4-6-13-24)27-22-30(43-35(27)40(45)52)36(48)42-21-10-3-2-9-20-41-29-16-11-15-26-34(29)39(51)46(38(26)50)31-18-19-33(47)44-37(31)49/h4-8,11-17,22-23,31,41,43H,2-3,9-10,18-21H2,1H3,(H,42,48)(H,44,47,49)","XLVMTIIWJDNJTG-UHFFFAOYSA-N"
"2644","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.3","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","714.779","714.280197556","4.82","53","7","9","4","13","171.7","C40H38N6O7","InChI=1S/C40H38N6O7/c1-45-23-28(25-14-7-8-17-32(25)53-24-12-5-4-6-13-24)27-22-30(43-35(27)40(45)52)36(48)42-21-10-3-2-9-20-41-29-16-11-15-26-34(29)39(51)46(38(26)50)31-18-19-33(47)44-37(31)49/h4-8,11-17,22-23,31,41,43H,2-3,9-10,18-21H2,1H3,(H,42,48)(H,44,47,49)","XLVMTIIWJDNJTG-UHFFFAOYSA-N"
"2644","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.3","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","714.779","714.280197556","4.82","53","7","9","4","13","171.7","C40H38N6O7","InChI=1S/C40H38N6O7/c1-45-23-28(25-14-7-8-17-32(25)53-24-12-5-4-6-13-24)27-22-30(43-35(27)40(45)52)36(48)42-21-10-3-2-9-20-41-29-16-11-15-26-34(29)39(51)46(38(26)50)31-18-19-33(47)44-37(31)49/h4-8,11-17,22-23,31,41,43H,2-3,9-10,18-21H2,1H3,(H,42,48)(H,44,47,49)","XLVMTIIWJDNJTG-UHFFFAOYSA-N"
"2645","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","185.35/24.33","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.07","58","7","10","5","16","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-49-25-30(27-14-5-6-17-34(27)58-26-12-3-2-4-13-26)29-24-32(47-38(29)43(49)57)39(53)46-23-8-7-18-35(51)45-22-10-9-21-44-31-16-11-15-28-37(31)42(56)50(41(28)55)33-19-20-36(52)48-40(33)54/h2-6,11-17,24-25,33,44,47H,7-10,18-23H2,1H3,(H,45,51)(H,46,53)(H,48,52,54)","YYFKCWRLNKAMER-UHFFFAOYSA-N"
"2645","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.07","58","7","10","5","16","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-49-25-30(27-14-5-6-17-34(27)58-26-12-3-2-4-13-26)29-24-32(47-38(29)43(49)57)39(53)46-23-8-7-18-35(51)45-22-10-9-21-44-31-16-11-15-28-37(31)42(56)50(41(28)55)33-19-20-36(52)48-40(33)54/h2-6,11-17,24-25,33,44,47H,7-10,18-23H2,1H3,(H,45,51)(H,46,53)(H,48,52,54)","YYFKCWRLNKAMER-UHFFFAOYSA-N"
"2645","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.07","58","7","10","5","16","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-49-25-30(27-14-5-6-17-34(27)58-26-12-3-2-4-13-26)29-24-32(47-38(29)43(49)57)39(53)46-23-8-7-18-35(51)45-22-10-9-21-44-31-16-11-15-28-37(31)42(56)50(41(28)55)33-19-20-36(52)48-40(33)54/h2-6,11-17,24-25,33,44,47H,7-10,18-23H2,1H3,(H,45,51)(H,46,53)(H,48,52,54)","YYFKCWRLNKAMER-UHFFFAOYSA-N"
"2646","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","277.55/38.84","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","84.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","799.885","799.3329614","4.42","59","7","10","5","17","200.8","C44H45N7O8","InChI=1S/C44H45N7O8/c1-50-26-31(28-15-7-8-18-35(28)59-27-13-4-2-5-14-27)30-25-33(48-39(30)44(50)58)40(54)47-24-9-3-6-19-36(52)46-23-11-10-22-45-32-17-12-16-29-38(32)43(57)51(42(29)56)34-20-21-37(53)49-41(34)55/h2,4-5,7-8,12-18,25-26,34,45,48H,3,6,9-11,19-24H2,1H3,(H,46,52)(H,47,54)(H,49,53,55)","FGROPBOFRPYTSY-UHFFFAOYSA-N"
"2646","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","84.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","799.885","799.3329614","4.42","59","7","10","5","17","200.8","C44H45N7O8","InChI=1S/C44H45N7O8/c1-50-26-31(28-15-7-8-18-35(28)59-27-13-4-2-5-14-27)30-25-33(48-39(30)44(50)58)40(54)47-24-9-3-6-19-36(52)46-23-11-10-22-45-32-17-12-16-29-38(32)43(57)51(42(29)56)34-20-21-37(53)49-41(34)55/h2,4-5,7-8,12-18,25-26,34,45,48H,3,6,9-11,19-24H2,1H3,(H,46,52)(H,47,54)(H,49,53,55)","FGROPBOFRPYTSY-UHFFFAOYSA-N"
"2646","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","84.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","799.885","799.3329614","4.42","59","7","10","5","17","200.8","C44H45N7O8","InChI=1S/C44H45N7O8/c1-50-26-31(28-15-7-8-18-35(28)59-27-13-4-2-5-14-27)30-25-33(48-39(30)44(50)58)40(54)47-24-9-3-6-19-36(52)46-23-11-10-22-45-32-17-12-16-29-38(32)43(57)51(42(29)56)34-20-21-37(53)49-41(34)55/h2,4-5,7-8,12-18,25-26,34,45,48H,3,6,9-11,19-24H2,1H3,(H,46,52)(H,47,54)(H,49,53,55)","FGROPBOFRPYTSY-UHFFFAOYSA-N"
"2647","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","331.9/35.72","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","30.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","813.912","813.348611464","4.97","60","7","10","5","18","200.8","C45H47N7O8","InChI=1S/C45H47N7O8/c1-51-27-32(29-16-8-9-19-36(29)60-28-14-5-4-6-15-28)31-26-34(49-40(31)45(51)59)41(55)48-25-10-3-2-7-20-37(53)47-24-12-11-23-46-33-18-13-17-30-39(33)44(58)52(43(30)57)35-21-22-38(54)50-42(35)56/h4-6,8-9,13-19,26-27,35,46,49H,2-3,7,10-12,20-25H2,1H3,(H,47,53)(H,48,55)(H,50,54,56)","FULJWWXLSFUQQH-UHFFFAOYSA-N"
"2647","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","30.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","813.912","813.348611464","4.97","60","7","10","5","18","200.8","C45H47N7O8","InChI=1S/C45H47N7O8/c1-51-27-32(29-16-8-9-19-36(29)60-28-14-5-4-6-15-28)31-26-34(49-40(31)45(51)59)41(55)48-25-10-3-2-7-20-37(53)47-24-12-11-23-46-33-18-13-17-30-39(33)44(58)52(43(30)57)35-21-22-38(54)50-42(35)56/h4-6,8-9,13-19,26-27,35,46,49H,2-3,7,10-12,20-25H2,1H3,(H,47,53)(H,48,55)(H,50,54,56)","FULJWWXLSFUQQH-UHFFFAOYSA-N"
"2647","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCCCCCCC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","30.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","813.912","813.348611464","4.97","60","7","10","5","18","200.8","C45H47N7O8","InChI=1S/C45H47N7O8/c1-51-27-32(29-16-8-9-19-36(29)60-28-14-5-4-6-15-28)31-26-34(49-40(31)45(51)59)41(55)48-25-10-3-2-7-20-37(53)47-24-12-11-23-46-33-18-13-17-30-39(33)44(58)52(43(30)57)35-21-22-38(54)50-42(35)56/h4-6,8-9,13-19,26-27,35,46,49H,2-3,7,10-12,20-25H2,1H3,(H,47,53)(H,48,55)(H,50,54,56)","FULJWWXLSFUQQH-UHFFFAOYSA-N"
"2648","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","65.34/27.22","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","819.875","819.301661272","4.88","61","8","10","5","14","200.8","C46H41N7O8","InChI=1S/C46H41N7O8/c1-52-26-33(30-12-5-6-15-37(30)61-29-10-3-2-4-11-29)32-24-35(50-40(32)46(52)60)42(56)49-25-27-16-18-28(19-17-27)41(55)48-23-8-7-22-47-34-14-9-13-31-39(34)45(59)53(44(31)58)36-20-21-38(54)51-43(36)57/h2-6,9-19,24,26,36,47,50H,7-8,20-23,25H2,1H3,(H,48,55)(H,49,56)(H,51,54,57)","AQPUUPNSVBDCBQ-UHFFFAOYSA-N"
"2648","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","819.875","819.301661272","4.88","61","8","10","5","14","200.8","C46H41N7O8","InChI=1S/C46H41N7O8/c1-52-26-33(30-12-5-6-15-37(30)61-29-10-3-2-4-11-29)32-24-35(50-40(32)46(52)60)42(56)49-25-27-16-18-28(19-17-27)41(55)48-23-8-7-22-47-34-14-9-13-31-39(34)45(59)53(44(31)58)36-20-21-38(54)51-43(36)57/h2-6,9-19,24,26,36,47,50H,7-8,20-23,25H2,1H3,(H,48,55)(H,49,56)(H,51,54,57)","AQPUUPNSVBDCBQ-UHFFFAOYSA-N"
"2648","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","819.875","819.301661272","4.88","61","8","10","5","14","200.8","C46H41N7O8","InChI=1S/C46H41N7O8/c1-52-26-33(30-12-5-6-15-37(30)61-29-10-3-2-4-11-29)32-24-35(50-40(32)46(52)60)42(56)49-25-27-16-18-28(19-17-27)41(55)48-23-8-7-22-47-34-14-9-13-31-39(34)45(59)53(44(31)58)36-20-21-38(54)51-43(36)57/h2-6,9-19,24,26,36,47,50H,7-8,20-23,25H2,1H3,(H,48,55)(H,49,56)(H,51,54,57)","AQPUUPNSVBDCBQ-UHFFFAOYSA-N"
"2649","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","99.75/295.6","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","863.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","727.778","727.275446524","3.35","54","7","9","5","12","191.57","C40H37N7O7","InChI=1S/C40H37N7O7/c1-46-22-28(24-8-3-2-4-9-24)27-20-30(44-34(27)40(46)54)36(50)43-21-23-12-14-25(15-13-23)35(49)42-19-6-5-18-41-29-11-7-10-26-33(29)39(53)47(38(26)52)31-16-17-32(48)45-37(31)51/h2-4,7-15,20,22,31,41,44H,5-6,16-19,21H2,1H3,(H,42,49)(H,43,50)(H,45,48,51)","HKTXOTNIEKLWFM-UHFFFAOYSA-N"
"2649","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","863.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","727.778","727.275446524","3.35","54","7","9","5","12","191.57","C40H37N7O7","InChI=1S/C40H37N7O7/c1-46-22-28(24-8-3-2-4-9-24)27-20-30(44-34(27)40(46)54)36(50)43-21-23-12-14-25(15-13-23)35(49)42-19-6-5-18-41-29-11-7-10-26-33(29)39(53)47(38(26)52)31-16-17-32(48)45-37(31)51/h2-4,7-15,20,22,31,41,44H,5-6,16-19,21H2,1H3,(H,42,49)(H,43,50)(H,45,48,51)","HKTXOTNIEKLWFM-UHFFFAOYSA-N"
"2649","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","863.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","727.778","727.275446524","3.35","54","7","9","5","12","191.57","C40H37N7O7","InChI=1S/C40H37N7O7/c1-46-22-28(24-8-3-2-4-9-24)27-20-30(44-34(27)40(46)54)36(50)43-21-23-12-14-25(15-13-23)35(49)42-19-6-5-18-41-29-11-7-10-26-33(29)39(53)47(38(26)52)31-16-17-32(48)45-37(31)51/h2-4,7-15,20,22,31,41,44H,5-6,16-19,21H2,1H3,(H,42,49)(H,43,50)(H,45,48,51)","HKTXOTNIEKLWFM-UHFFFAOYSA-N"
"2650","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC(C(C)(C)O)=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","45.41/72.98","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4127.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","3.05","58","7","10","6","13","211.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-43(2,58)27-9-6-8-26(20-27)30-23-49(3)42(57)36-29(30)21-32(47-36)38(53)46-22-24-12-14-25(15-13-24)37(52)45-19-5-4-18-44-31-11-7-10-28-35(31)41(56)50(40(28)55)33-16-17-34(51)48-39(33)54/h6-15,20-21,23,33,44,47,58H,4-5,16-19,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","WCSKJSMYQBVCPR-UHFFFAOYSA-N"
"2650","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC(C(C)(C)O)=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4127.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","3.05","58","7","10","6","13","211.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-43(2,58)27-9-6-8-26(20-27)30-23-49(3)42(57)36-29(30)21-32(47-36)38(53)46-22-24-12-14-25(15-13-24)37(52)45-19-5-4-18-44-31-11-7-10-28-35(31)41(56)50(40(28)55)33-16-17-34(51)48-39(33)54/h6-15,20-21,23,33,44,47,58H,4-5,16-19,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","WCSKJSMYQBVCPR-UHFFFAOYSA-N"
"2650","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC(C(C)(C)O)=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4127.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","3.05","58","7","10","6","13","211.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-43(2,58)27-9-6-8-26(20-27)30-23-49(3)42(57)36-29(30)21-32(47-36)38(53)46-22-24-12-14-25(15-13-24)37(52)45-19-5-4-18-44-31-11-7-10-28-35(31)41(56)50(40(28)55)33-16-17-34(51)48-39(33)54/h6-15,20-21,23,33,44,47,58H,4-5,16-19,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","WCSKJSMYQBVCPR-UHFFFAOYSA-N"
"2651","O60885","BRD4","CRBN","","","CC(C)OC1=CC=CC=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","83.65/91.49","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.12","58","7","10","5","14","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-24(2)58-34-12-5-4-9-27(34)30-23-49(3)43(57)37-29(30)21-32(47-37)39(53)46-22-25-13-15-26(16-14-25)38(52)45-20-7-6-19-44-31-11-8-10-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h4-5,8-16,21,23-24,33,44,47H,6-7,17-20,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","JCNSBZXEZZGTJU-UHFFFAOYSA-N"
"2651","P25440","BRD2","CRBN","","","CC(C)OC1=CC=CC=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.12","58","7","10","5","14","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-24(2)58-34-12-5-4-9-27(34)30-23-49(3)43(57)37-29(30)21-32(47-37)39(53)46-22-25-13-15-26(16-14-25)38(52)45-20-7-6-19-44-31-11-8-10-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h4-5,8-16,21,23-24,33,44,47H,6-7,17-20,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","JCNSBZXEZZGTJU-UHFFFAOYSA-N"
"2651","Q15059","BRD3","CRBN","","","CC(C)OC1=CC=CC=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","785.858","785.317311336","4.12","58","7","10","5","14","200.8","C43H43N7O8","InChI=1S/C43H43N7O8/c1-24(2)58-34-12-5-4-9-27(34)30-23-49(3)43(57)37-29(30)21-32(47-37)39(53)46-22-25-13-15-26(16-14-25)38(52)45-20-7-6-19-44-31-11-8-10-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h4-5,8-16,21,23-24,33,44,47H,6-7,17-20,22H2,1-3H3,(H,45,52)(H,46,53)(H,48,51,54)","JCNSBZXEZZGTJU-UHFFFAOYSA-N"
"2652","O60885","BRD4","CRBN","","","CN1C=C(C2=CC=CC=C2OC2CC2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","54.31/96.4","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","783.842","783.301661272","3.87","58","8","10","5","14","200.8","C43H41N7O8","InChI=1S/C43H41N7O8/c1-49-23-30(27-7-2-3-10-34(27)58-26-15-16-26)29-21-32(47-37(29)43(49)57)39(53)46-22-24-11-13-25(14-12-24)38(52)45-20-5-4-19-44-31-9-6-8-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h2-3,6-14,21,23,26,33,44,47H,4-5,15-20,22H2,1H3,(H,45,52)(H,46,53)(H,48,51,54)","INIGWOALAMGUGD-UHFFFAOYSA-N"
"2652","P25440","BRD2","CRBN","","","CN1C=C(C2=CC=CC=C2OC2CC2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","783.842","783.301661272","3.87","58","8","10","5","14","200.8","C43H41N7O8","InChI=1S/C43H41N7O8/c1-49-23-30(27-7-2-3-10-34(27)58-26-15-16-26)29-21-32(47-37(29)43(49)57)39(53)46-22-24-11-13-25(14-12-24)38(52)45-20-5-4-19-44-31-9-6-8-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h2-3,6-14,21,23,26,33,44,47H,4-5,15-20,22H2,1H3,(H,45,52)(H,46,53)(H,48,51,54)","INIGWOALAMGUGD-UHFFFAOYSA-N"
"2652","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC=CC=C2OC2CC2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","783.842","783.301661272","3.87","58","8","10","5","14","200.8","C43H41N7O8","InChI=1S/C43H41N7O8/c1-49-23-30(27-7-2-3-10-34(27)58-26-15-16-26)29-21-32(47-37(29)43(49)57)39(53)46-22-24-11-13-25(14-12-24)38(52)45-20-5-4-19-44-31-9-6-8-28-36(31)42(56)50(41(28)55)33-17-18-35(51)48-40(33)54/h2-3,6-14,21,23,26,33,44,47H,4-5,15-20,22H2,1H3,(H,45,52)(H,46,53)(H,48,51,54)","INIGWOALAMGUGD-UHFFFAOYSA-N"
"2653","O60885","BRD4","CRBN","","","C=C(C)C1=CC=C(OC(C)C)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","118.6/100.53","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","825.923","825.348611464","5.52","61","7","10","5","15","200.8","C46H47N7O8","InChI=1S/C46H47N7O8/c1-25(2)29-15-17-37(61-26(3)4)31(21-29)33-24-52(5)46(60)40-32(33)22-35(50-40)42(56)49-23-27-11-13-28(14-12-27)41(55)48-20-7-6-19-47-34-10-8-9-30-39(34)45(59)53(44(30)58)36-16-18-38(54)51-43(36)57/h8-15,17,21-22,24,26,36,47,50H,1,6-7,16,18-20,23H2,2-5H3,(H,48,55)(H,49,56)(H,51,54,57)","TVJXUCIJZAVROI-UHFFFAOYSA-N"
"2653","P25440","BRD2","CRBN","","","C=C(C)C1=CC=C(OC(C)C)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","825.923","825.348611464","5.52","61","7","10","5","15","200.8","C46H47N7O8","InChI=1S/C46H47N7O8/c1-25(2)29-15-17-37(61-26(3)4)31(21-29)33-24-52(5)46(60)40-32(33)22-35(50-40)42(56)49-23-27-11-13-28(14-12-27)41(55)48-20-7-6-19-47-34-10-8-9-30-39(34)45(59)53(44(30)58)36-16-18-38(54)51-43(36)57/h8-15,17,21-22,24,26,36,47,50H,1,6-7,16,18-20,23H2,2-5H3,(H,48,55)(H,49,56)(H,51,54,57)","TVJXUCIJZAVROI-UHFFFAOYSA-N"
"2653","Q15059","BRD3","CRBN","","","C=C(C)C1=CC=C(OC(C)C)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","825.923","825.348611464","5.52","61","7","10","5","15","200.8","C46H47N7O8","InChI=1S/C46H47N7O8/c1-25(2)29-15-17-37(61-26(3)4)31(21-29)33-24-52(5)46(60)40-32(33)22-35(50-40)42(56)49-23-27-11-13-28(14-12-27)41(55)48-20-7-6-19-47-34-10-8-9-30-39(34)45(59)53(44(30)58)36-16-18-38(54)51-43(36)57/h8-15,17,21-22,24,26,36,47,50H,1,6-7,16,18-20,23H2,2-5H3,(H,48,55)(H,49,56)(H,51,54,57)","TVJXUCIJZAVROI-UHFFFAOYSA-N"
"2654","O60885","BRD4","CRBN","","","C=C(C)C1=CC=C(OC2=CC=CC=C2)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","241.45/74.12","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","859.94","859.3329614","6.28","64","8","10","5","15","200.8","C49H45N7O8","InChI=1S/C49H45N7O8/c1-28(2)31-18-20-40(64-32-10-5-4-6-11-32)34(24-31)36-27-55(3)49(63)43-35(36)25-38(53-43)45(59)52-26-29-14-16-30(17-15-29)44(58)51-23-8-7-22-50-37-13-9-12-33-42(37)48(62)56(47(33)61)39-19-21-41(57)54-46(39)60/h4-6,9-18,20,24-25,27,39,50,53H,1,7-8,19,21-23,26H2,2-3H3,(H,51,58)(H,52,59)(H,54,57,60)","MYVDBDYVHBZGPP-UHFFFAOYSA-N"
"2654","P25440","BRD2","CRBN","","","C=C(C)C1=CC=C(OC2=CC=CC=C2)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","859.94","859.3329614","6.28","64","8","10","5","15","200.8","C49H45N7O8","InChI=1S/C49H45N7O8/c1-28(2)31-18-20-40(64-32-10-5-4-6-11-32)34(24-31)36-27-55(3)49(63)43-35(36)25-38(53-43)45(59)52-26-29-14-16-30(17-15-29)44(58)51-23-8-7-22-50-37-13-9-12-33-42(37)48(62)56(47(33)61)39-19-21-41(57)54-46(39)60/h4-6,9-18,20,24-25,27,39,50,53H,1,7-8,19,21-23,26H2,2-3H3,(H,51,58)(H,52,59)(H,54,57,60)","MYVDBDYVHBZGPP-UHFFFAOYSA-N"
"2654","Q15059","BRD3","CRBN","","","C=C(C)C1=CC=C(OC2=CC=CC=C2)C(C2=CN(C)C(=O)C3=C2C=C(C(=O)NCC2=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C2)[NH]3)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","859.94","859.3329614","6.28","64","8","10","5","15","200.8","C49H45N7O8","InChI=1S/C49H45N7O8/c1-28(2)31-18-20-40(64-32-10-5-4-6-11-32)34(24-31)36-27-55(3)49(63)43-35(36)25-38(53-43)45(59)52-26-29-14-16-30(17-15-29)44(58)51-23-8-7-22-50-37-13-9-12-33-42(37)48(62)56(47(33)61)39-19-21-41(57)54-46(39)60/h4-6,9-18,20,24-25,27,39,50,53H,1,7-8,19,21-23,26H2,2-3H3,(H,51,58)(H,52,59)(H,54,57,60)","MYVDBDYVHBZGPP-UHFFFAOYSA-N"
"2655","O60885","BRD4","CRBN","","","CC(C)OC1=CC=C(C(C)(C)O)C=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","24.55/13.92","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","843.938","843.359176148","3.82","62","7","11","6","15","221.03","C46H49N7O9","InChI=1S/C46H49N7O9/c1-25(2)62-36-17-15-28(46(3,4)61)21-30(36)32-24-52(5)45(60)39-31(32)22-34(50-39)41(56)49-23-26-11-13-27(14-12-26)40(55)48-20-7-6-19-47-33-10-8-9-29-38(33)44(59)53(43(29)58)35-16-18-37(54)51-42(35)57/h8-15,17,21-22,24-25,35,47,50,61H,6-7,16,18-20,23H2,1-5H3,(H,48,55)(H,49,56)(H,51,54,57)","JNYTXMVDYCNZAK-UHFFFAOYSA-N"
"2655","P25440","BRD2","CRBN","","","CC(C)OC1=CC=C(C(C)(C)O)C=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","843.938","843.359176148","3.82","62","7","11","6","15","221.03","C46H49N7O9","InChI=1S/C46H49N7O9/c1-25(2)62-36-17-15-28(46(3,4)61)21-30(36)32-24-52(5)45(60)39-31(32)22-34(50-39)41(56)49-23-26-11-13-27(14-12-26)40(55)48-20-7-6-19-47-33-10-8-9-29-38(33)44(59)53(43(29)58)35-16-18-37(54)51-42(35)57/h8-15,17,21-22,24-25,35,47,50,61H,6-7,16,18-20,23H2,1-5H3,(H,48,55)(H,49,56)(H,51,54,57)","JNYTXMVDYCNZAK-UHFFFAOYSA-N"
"2655","Q15059","BRD3","CRBN","","","CC(C)OC1=CC=C(C(C)(C)O)C=C1C1=CN(C)C(=O)C2=C1C=C(C(=O)NCC1=CC=C(C(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C1)[NH]2","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.33","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","843.938","843.359176148","3.82","62","7","11","6","15","221.03","C46H49N7O9","InChI=1S/C46H49N7O9/c1-25(2)62-36-17-15-28(46(3,4)61)21-30(36)32-24-52(5)45(60)39-31(32)22-34(50-39)41(56)49-23-26-11-13-27(14-12-26)40(55)48-20-7-6-19-47-33-10-8-9-29-38(33)44(59)53(43(29)58)35-16-18-37(54)51-42(35)57/h8-15,17,21-22,24-25,35,47,50,61H,6-7,16,18-20,23H2,1-5H3,(H,48,55)(H,49,56)(H,51,54,57)","JNYTXMVDYCNZAK-UHFFFAOYSA-N"
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"2657","O60885","BRD4","CRBN","","","CN1C=C(C2=CC(C(C)(C)O)=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","29.54/3.82","IC50 of BRD4 BD1/2 was assessed by HTRF","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","877.955","877.343526084","4.58","65","8","11","6","15","221.03","C49H47N7O9","InChI=1S/C49H47N7O9/c1-49(2,64)30-18-20-39(65-31-10-5-4-6-11-31)33(24-30)35-27-55(3)48(63)42-34(35)25-37(53-42)44(59)52-26-28-14-16-29(17-15-28)43(58)51-23-8-7-22-50-36-13-9-12-32-41(36)47(62)56(46(32)61)38-19-21-40(57)54-45(38)60/h4-6,9-18,20,24-25,27,38,50,53,64H,7-8,19,21-23,26H2,1-3H3,(H,51,58)(H,52,59)(H,54,57,60)","HBAAAVQUHXUWNR-UHFFFAOYSA-N"
"2657","P25440","BRD2","CRBN","","","CN1C=C(C2=CC(C(C)(C)O)=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","877.955","877.343526084","4.58","65","8","11","6","15","221.03","C49H47N7O9","InChI=1S/C49H47N7O9/c1-49(2,64)30-18-20-39(65-31-10-5-4-6-11-31)33(24-30)35-27-55(3)48(63)42-34(35)25-37(53-42)44(59)52-26-28-14-16-29(17-15-28)43(58)51-23-8-7-22-50-36-13-9-12-32-41(36)47(62)56(46(32)61)38-19-21-40(57)54-45(38)60/h4-6,9-18,20,24-25,27,38,50,53,64H,7-8,19,21-23,26H2,1-3H3,(H,51,58)(H,52,59)(H,54,57,60)","HBAAAVQUHXUWNR-UHFFFAOYSA-N"
"2657","Q15059","BRD3","CRBN","","","CN1C=C(C2=CC(C(C)(C)O)=CC=C2OC2=CC=CC=C2)C2=C([NH]C(C(=O)NCC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=C2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.67","Inhibit proliferation of MV-4-11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114259","877.955","877.343526084","4.58","65","8","11","6","15","221.03","C49H47N7O9","InChI=1S/C49H47N7O9/c1-49(2,64)30-18-20-39(65-31-10-5-4-6-11-31)33(24-30)35-27-55(3)48(63)42-34(35)25-37(53-42)44(59)52-26-28-14-16-29(17-15-28)43(58)51-23-8-7-22-50-36-13-9-12-32-41(36)47(62)56(46(32)61)38-19-21-40(57)54-45(38)60/h4-6,9-18,20,24-25,27,38,50,53,64H,7-8,19,21-23,26H2,1-3H3,(H,51,58)(H,52,59)(H,54,57,60)","HBAAAVQUHXUWNR-UHFFFAOYSA-N"
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"2677","P14679","TYR","CRBN","","","N[C@@H](CC1=CC=C(O)C(O)=C1)C(=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","58900","Inhibition of TYR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113850","583.598","583.227827636","0.05","42","4","11","6","14","209.62","C28H33N5O9","InChI=1S/C28H33N5O9/c29-18(14-16-4-6-21(34)22(35)15-16)25(37)31-9-11-42-13-12-41-10-8-30-19-3-1-2-17-24(19)28(40)33(27(17)39)20-5-7-23(36)32-26(20)38/h1-4,6,15,18,20,30,34-35H,5,7-14,29H2,(H,31,37)(H,32,36,38)/t18-,20?/m0/s1","QXSFLNDAQXWTDY-LROBGIAVSA-N"
"2678","P24941","CDK2","CRBN","","","CC1=NC=C(C2=CC=NC(NC3=CC=C(S(=O)(=O)CCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)C=C3)=N2)N1C(C)C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113849","898.016","897.359193212","2.25","64","7","18","3","23","243.75","C43H51N11O9S","InChI=1S/C43H51N11O9S/c1-28(2)53-29(3)46-26-37(53)34-15-16-45-43(48-34)47-30-9-11-32(12-10-30)64(59,60)25-5-6-31-27-52(51-50-31)18-20-62-22-24-63-23-21-61-19-17-44-35-8-4-7-33-39(35)42(58)54(41(33)57)36-13-14-38(55)49-40(36)56/h4,7-12,15-16,26-28,36,44H,5-6,13-14,17-25H2,1-3H3,(H,45,47,48)(H,49,55,56)","AKHSXHXLQGTLRL-UHFFFAOYSA-N"
"2679","P24941","CDK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCN3C=C(CCCS(=O)(=O)C4=CC=C(NC5=NC=CC(C6=CN=C(C)N6C(C)C)=N5)C=C4)N=N3)C(C)(C)C)C=C2)SC=N1","100","","Degradation of CDK2 in HEI-OC1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113849","981.219","980.41493426","4.22","69","7","17","4","20","241.34","C48H60N12O7S2","InChI=1S/C48H60N12O7S2/c1-30(2)60-32(4)50-25-41(60)39-18-19-49-47(54-39)53-35-14-16-38(17-15-35)69(65,66)22-8-9-36-26-58(57-56-36)20-21-67-28-42(62)55-44(48(5,6)7)46(64)59-27-37(61)23-40(59)45(63)51-24-33-10-12-34(13-11-33)43-31(3)52-29-68-43/h10-19,25-26,29-30,37,40,44,61H,8-9,20-24,27-28H2,1-7H3,(H,51,63)(H,55,62)(H,49,53,54)/t37-,40+,44-/m1/s1","XVCGNRHPFMMQTF-OUZJXKGJSA-N"
"2680","P24941","CDK2","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCN4C=C(CO[C@H]5CC[C@H](NC(=O)C6=N[NH]C=C6NC(=O)C6=C(F)C=CC=C6F)CC5)N=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113849","876.875","876.336644112","1.82","63","7","15","5","21","250.09","C41H46F2N10O10","InChI=1S/C41H46F2N10O10/c42-28-4-2-5-29(43)35(28)38(56)47-31-21-45-50-36(31)39(57)46-24-7-9-26(10-8-24)63-23-25-22-52(51-49-25)14-16-61-18-20-62-19-17-60-15-13-44-30-6-1-3-27-34(30)41(59)53(40(27)58)32-11-12-33(54)48-37(32)55/h1-6,21-22,24,26,32,44H,7-20,23H2,(H,45,50)(H,46,57)(H,47,56)(H,48,54,55)/t24-,26-,32?","VJXUYBSLUCBRPW-YVDKMHGASA-N"
"2681","P24941","CDK2","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCCN3C=C(CO[C@H]4CC[C@H](NC(=O)C5=N[NH]C=C5NC(=O)C5=C(F)C=CC=C5F)CC4)N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113849","960.078","959.39238516","3.8","68","7","14","6","18","247.68","C46H55F2N11O8S","InChI=1S/C46H55F2N11O8S/c1-26-40(68-25-50-26)28-10-8-27(9-11-28)19-49-42(62)36-18-31(60)22-59(36)45(65)41(46(2,3)4)54-37(61)24-66-17-16-58-21-30(55-57-58)23-67-32-14-12-29(13-15-32)52-44(64)39-35(20-51-56-39)53-43(63)38-33(47)6-5-7-34(38)48/h5-11,20-21,25,29,31-32,36,41,60H,12-19,22-24H2,1-4H3,(H,49,62)(H,51,56)(H,52,64)(H,53,63)(H,54,61)/t29-,31-,32-,36+,41-/m1/s1","JBYYGVGCHRZJQH-XZAQPSMJSA-N"
"2682","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","151","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21","Inhibit proliferation of MV4-11 cells","","","","","","","","11a","","","","","","","10.1016/j.ejmech.2021.113922","902.07","901.459893228","5.79","66","9","15","3","16","206.11","C48H59N11O7","InChI=1S/C48H59N11O7/c1-4-35-43-55-54-29(2)58(43)37-27-49-48(53-42(37)57(35)28-30-12-7-5-8-13-30)51-34-17-16-31(26-39(34)65-3)44(61)50-32-20-23-56(24-21-32)22-9-6-10-25-66-38-15-11-14-33-41(38)47(64)59(46(33)63)36-18-19-40(60)52-45(36)62/h11,14-17,26-27,30,32,35-36H,4-10,12-13,18-25,28H2,1-3H3,(H,50,61)(H,49,51,53)(H,52,60,62)/t35-,36?/m1/s1","ZHYQBWGBTQAYNU-RERZGLEZSA-N"
"2683","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","121","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","184","Inhibit proliferation of MV4-11 cells","","","","","","","","11b","","","","","","","10.1016/j.ejmech.2021.113922","916.097","915.475543292","6.14","67","9","15","3","17","206.11","C49H61N11O7","InChI=1S/C49H61N11O7/c1-4-36-44-56-55-30(2)59(44)38-28-50-49(54-43(38)58(36)29-31-13-8-7-9-14-31)52-35-18-17-32(27-40(35)66-3)45(62)51-33-21-24-57(25-22-33)23-10-5-6-11-26-67-39-16-12-15-34-42(39)48(65)60(47(34)64)37-19-20-41(61)53-46(37)63/h12,15-18,27-28,31,33,36-37H,4-11,13-14,19-26,29H2,1-3H3,(H,51,62)(H,50,52,54)(H,53,61,63)/t36-,37?/m1/s1","RRIFTIGEWSMNLK-RKROREJRSA-N"
"2684","O60885","BRD4","CRBN","","WWL0202","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","209","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8/32.1/64.2","Inhibit proliferation of MV4-11/LNCaP/22Rv1 cells","","","","","","","","11c(WWL0202)","","","","","","","10.1016/j.ejmech.2021.113922","930.124","929.491193356","6.68","68","9","15","3","18","206.11","C50H63N11O7","InChI=1S/C50H63N11O7/c1-4-37-45-57-56-31(2)60(45)39-29-51-50(55-44(39)59(37)30-32-14-9-8-10-15-32)53-36-19-18-33(28-41(36)67-3)46(63)52-34-22-25-58(26-23-34)24-11-6-5-7-12-27-68-40-17-13-16-35-43(40)49(66)61(48(35)65)38-20-21-42(62)54-47(38)64/h13,16-19,28-29,32,34,37-38H,4-12,14-15,20-27,30H2,1-3H3,(H,52,63)(H,51,53,55)(H,54,62,64)/t37-,38?/m1/s1","WMCQTFNRVRZVSG-MLPLAHBKSA-N"
"2685","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","344","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","85","Inhibit proliferation of MV4-11 cells","","","","","","","","11d","","","","","","","10.1016/j.ejmech.2021.113922","944.151","943.50684342","7.23","69","9","15","3","19","206.11","C51H65N11O7","InChI=1S/C51H65N11O7/c1-4-38-46-58-57-32(2)61(46)40-30-52-51(56-45(40)60(38)31-33-15-10-9-11-16-33)54-37-20-19-34(29-42(37)68-3)47(64)53-35-23-26-59(27-24-35)25-12-7-5-6-8-13-28-69-41-18-14-17-36-44(41)50(67)62(49(36)66)39-21-22-43(63)55-48(39)65/h14,17-20,29-30,33,35,38-39H,4-13,15-16,21-28,31H2,1-3H3,(H,53,64)(H,52,54,56)(H,55,63,65)/t38-,39?/m1/s1","VLUDNLDRTOYHAK-SWGHGFEUSA-N"
"2686","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","225","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","36","Inhibit proliferation of MV4-11 cells","","","","","","","","11e","","","","","","","10.1016/j.ejmech.2021.113922","958.178","957.522493484","7.77","70","9","15","3","20","206.11","C52H67N11O7","InChI=1S/C52H67N11O7/c1-4-39-47-59-58-33(2)62(47)41-31-53-52(57-46(41)61(39)32-34-16-11-10-12-17-34)55-38-21-20-35(30-43(38)69-3)48(65)54-36-24-27-60(28-25-36)26-13-8-6-5-7-9-14-29-70-42-19-15-18-37-45(42)51(68)63(50(37)67)40-22-23-44(64)56-49(40)66/h15,18-21,30-31,34,36,39-40H,4-14,16-17,22-29,32H2,1-3H3,(H,54,65)(H,53,55,57)(H,56,64,66)/t39-,40?/m1/s1","CMQKEDHPTQZDSM-IPVUVHESSA-N"
"2687","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","284","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","153","Inhibit proliferation of MV4-11 cells","","","","","","","","11f","","","","","","","10.1016/j.ejmech.2021.113922","972.205","971.538143548","8.31","71","9","15","3","21","206.11","C53H69N11O7","InChI=1S/C53H69N11O7/c1-4-40-48-60-59-34(2)63(48)42-32-54-53(58-47(42)62(40)33-35-17-12-11-13-18-35)56-39-22-21-36(31-44(39)70-3)49(66)55-37-25-28-61(29-26-37)27-14-9-7-5-6-8-10-15-30-71-43-20-16-19-38-46(43)52(69)64(51(38)68)41-23-24-45(65)57-50(41)67/h16,19-22,31-32,35,37,40-41H,4-15,17-18,23-30,33H2,1-3H3,(H,55,66)(H,54,56,58)(H,57,65,67)/t40-,41?/m1/s1","ZCDWJQMEWFYKEZ-AXHXVYJZSA-N"
"2688","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCCCCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","379","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","188","Inhibit proliferation of MV4-11 cells","","","","","","","","11g","","","","","","","10.1016/j.ejmech.2021.113922","986.232","985.553793612","8.85","72","9","15","3","22","206.11","C54H71N11O7","InChI=1S/C54H71N11O7/c1-4-41-49-61-60-35(2)64(49)43-33-55-54(59-48(43)63(41)34-36-18-13-12-14-19-36)57-40-23-22-37(32-45(40)71-3)50(67)56-38-26-29-62(30-27-38)28-15-10-8-6-5-7-9-11-16-31-72-44-21-17-20-39-47(44)53(70)65(52(39)69)42-24-25-46(66)58-51(42)68/h17,20-23,32-33,36,38,41-42H,4-16,18-19,24-31,34H2,1-3H3,(H,56,67)(H,55,57,59)(H,58,66,68)/t41-,42?/m1/s1","FLCJPIAJDUZOIY-HRCVVWNVSA-N"
"2689","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","219","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","359","Inhibit proliferation of MV4-11 cells","","","","","","","","11h","","","","","","","10.1016/j.ejmech.2021.113922","945.095","944.46570688","4.77","69","9","16","4","17","235.21","C49H60N12O8","InChI=1S/C49H60N12O8/c1-4-35-44-57-56-29(2)60(44)37-26-51-49(55-43(37)59(35)27-30-11-6-5-7-12-30)53-34-16-15-31(25-39(34)68-3)45(64)52-32-19-23-58(24-20-32)22-9-8-21-50-41(63)28-69-38-14-10-13-33-42(38)48(67)61(47(33)66)36-17-18-40(62)54-46(36)65/h10,13-16,25-26,30,32,35-36H,4-9,11-12,17-24,27-28H2,1-3H3,(H,50,63)(H,52,64)(H,51,53,55)(H,54,62,65)/t35-,36?/m1/s1","JTGQHROHFUISIK-RERZGLEZSA-N"
"2690","O60885","BRD4","CRBN","","WWL0245","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","<1/<1",">99/>99","Degradation of BRD4 in 22Rv1/VCaP cells after 24 h treatment","","","254","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3/20.8/52.9","Inhibit proliferation of MV4-11/LNCaP/22Rv1 cells","","","","","","","","12a(WWL0245)","","","","","","","10.1016/j.ejmech.2021.113922","873.972","873.392207592","4.21","64","9","15","3","12","223.18","C45H51N11O8","InChI=1S/C45H51N11O8/c1-4-31-40-52-51-25(2)55(40)33-22-46-45(50-39(33)54(31)23-26-9-6-5-7-10-26)48-30-14-13-27(21-35(30)63-3)41(59)47-28-17-19-53(20-18-28)37(58)24-64-34-12-8-11-29-38(34)44(62)56(43(29)61)32-15-16-36(57)49-42(32)60/h8,11-14,21-22,26,28,31-32H,4-7,9-10,15-20,23-24H2,1-3H3,(H,47,59)(H,46,48,50)(H,49,57,60)/t31-,32?/m1/s1","AORZPRLVKUMTOJ-XGDNGBMYSA-N"
"2691","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","739","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18","Inhibit proliferation of MV4-11 cells","","","","","","","","12b","","","","","","","10.1016/j.ejmech.2021.113922","902.026","901.42350772","4.47","66","9","15","3","14","223.18","C47H55N11O8","InChI=1S/C47H55N11O8/c1-4-33-42-54-53-27(2)57(42)35-25-48-47(52-41(35)56(33)26-28-10-6-5-7-11-28)50-32-16-15-29(24-37(32)65-3)43(61)49-30-19-21-55(22-20-30)39(60)14-9-23-66-36-13-8-12-31-40(36)46(64)58(45(31)63)34-17-18-38(59)51-44(34)62/h8,12-13,15-16,24-25,28,30,33-34H,4-7,9-11,14,17-23,26H2,1-3H3,(H,49,61)(H,48,50,52)(H,51,59,62)/t33-,34?/m1/s1","GBOOMURPCSMHOP-BONSOQDYSA-N"
"2692","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","370","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13","Inhibit proliferation of MV4-11 cells","","","","","","","","12c","","","","","","","10.1016/j.ejmech.2021.113922","916.053","915.439157784","4.82","67","9","15","3","15","223.18","C48H57N11O8","InChI=1S/C48H57N11O8/c1-4-34-43-55-54-28(2)58(43)36-26-49-48(53-42(36)57(34)27-29-11-6-5-7-12-29)51-33-17-16-30(25-38(33)66-3)44(62)50-31-20-22-56(23-21-31)40(61)15-8-9-24-67-37-14-10-13-32-41(37)47(65)59(46(32)64)35-18-19-39(60)52-45(35)63/h10,13-14,16-17,25-26,29,31,34-35H,4-9,11-12,15,18-24,27H2,1-3H3,(H,50,62)(H,49,51,53)(H,52,60,63)/t34-,35?/m1/s1","RXBBVTLHCZOFSY-IFDNYZKCSA-N"
"2693","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","435","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7","Inhibit proliferation of MV4-11 cells","","","","","","","","12d","","","","","","","10.1016/j.ejmech.2021.113922","930.08","929.454807848","5.18","68","9","15","3","16","223.18","C49H59N11O8","InChI=1S/C49H59N11O8/c1-4-35-44-56-55-29(2)59(44)37-27-50-49(54-43(37)58(35)28-30-12-7-5-8-13-30)52-34-18-17-31(26-39(34)67-3)45(63)51-32-21-23-57(24-22-32)41(62)16-9-6-10-25-68-38-15-11-14-33-42(38)48(66)60(47(33)65)36-19-20-40(61)53-46(36)64/h11,14-15,17-18,26-27,30,32,35-36H,4-10,12-13,16,19-25,28H2,1-3H3,(H,51,63)(H,50,52,54)(H,53,61,64)/t35-,36?/m1/s1","VLWJPCFAVATLSZ-RERZGLEZSA-N"
"2694","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","658","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10","Inhibit proliferation of MV4-11 cells","","","","","","","","12e","","","","","","","10.1016/j.ejmech.2021.113922","944.107","943.470457912","5.72","69","9","15","3","17","223.18","C50H61N11O8","InChI=1S/C50H61N11O8/c1-4-36-45-57-56-30(2)60(45)38-28-51-50(55-44(38)59(36)29-31-13-8-7-9-14-31)53-35-19-18-32(27-40(35)68-3)46(64)52-33-22-24-58(25-23-33)42(63)17-10-5-6-11-26-69-39-16-12-15-34-43(39)49(67)61(48(34)66)37-20-21-41(62)54-47(37)65/h12,15-16,18-19,27-28,31,33,36-37H,4-11,13-14,17,20-26,29H2,1-3H3,(H,52,64)(H,51,53,55)(H,54,62,65)/t36-,37?/m1/s1","MJKCEEDXZGWAIW-RKROREJRSA-N"
"2695","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CNC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","259","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18","Inhibit proliferation of MV4-11 cells","","","","","","","","13a","","","","","","","10.1016/j.ejmech.2021.113922","859.005","858.428927448","4.27","63","9","14","4","12","208.91","C45H54N12O6","InChI=1S/C45H54N12O6/c1-4-34-41-53-52-26(2)57(41)36-22-47-45(51-40(36)55(34)24-27-9-6-5-7-10-27)49-33-14-13-28(21-37(33)63-3)42(60)48-29-17-19-54(20-18-29)39(59)23-46-32-12-8-11-30-31(32)25-56(44(30)62)35-15-16-38(58)50-43(35)61/h8,11-14,21-22,27,29,34-35,46H,4-7,9-10,15-20,23-25H2,1-3H3,(H,48,60)(H,47,49,51)(H,50,58,61)/t34-,35?/m1/s1","AXAUUAVSPYBRSD-IFDNYZKCSA-N"
"2696","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCNC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","311","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","753","Inhibit proliferation of MV4-11 cells","","","","","","","","13b","","","","","","","10.1016/j.ejmech.2021.113922","901.086","900.47587764","4.89","66","9","14","4","15","208.91","C48H60N12O6","InChI=1S/C48H60N12O6/c1-4-37-44-56-55-29(2)60(44)39-26-50-48(54-43(39)58(37)27-30-11-6-5-7-12-30)52-36-17-16-31(25-40(36)66-3)45(63)51-32-20-23-57(24-21-32)42(62)15-8-9-22-49-35-14-10-13-33-34(35)28-59(47(33)65)38-18-19-41(61)53-46(38)64/h10,13-14,16-17,25-26,30,32,37-38,49H,4-9,11-12,15,18-24,27-28H2,1-3H3,(H,51,63)(H,50,52,54)(H,53,61,64)/t37-,38?/m1/s1","JESXHWUBMBVYMW-MLPLAHBKSA-N"
"2697","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCCNC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","288","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10","Inhibit proliferation of MV4-11 cells","","","","","","","","13c","","","","","","","10.1016/j.ejmech.2021.113922","915.113","914.491527704","5.25","67","9","14","4","16","208.91","C49H62N12O6","InChI=1S/C49H62N12O6/c1-4-38-45-57-56-30(2)61(45)40-27-51-49(55-44(40)59(38)28-31-12-7-5-8-13-31)53-37-18-17-32(26-41(37)67-3)46(64)52-33-21-24-58(25-22-33)43(63)16-9-6-10-23-50-36-15-11-14-34-35(36)29-60(48(34)66)39-19-20-42(62)54-47(39)65/h11,14-15,17-18,26-27,31,33,38-39,50H,4-10,12-13,16,19-25,28-29H2,1-3H3,(H,52,64)(H,51,53,55)(H,54,62,65)/t38-,39?/m1/s1","BXEHPWUOZLISND-SWGHGFEUSA-N"
"2698","O60885","BRD4","CRBN","","","CC[C@@H]1C2=NN=C(C)N2C2=CN=C(NC3=CC=C(C(=O)NC4CCN(C(=O)CCCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=C3OC)N=C2N1CC1CCCCC1","","","","","","190","IC50 was assessed by a radiometric ATP-competitive kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","671","Inhibit proliferation of MV4-11 cells","","","","","","","","13d","","","","","","","10.1016/j.ejmech.2021.113922","957.15","956.502092388","5.1","70","9","14","4","17","225.98","C51H64N12O7","InChI=1S/C51H64N12O7/c1-4-39-47-59-58-31(2)63(47)41-28-52-51(57-46(41)61(39)29-32-13-8-7-9-14-32)55-38-20-19-33(27-42(38)70-3)48(67)53-34-23-25-60(26-24-34)45(66)18-11-6-5-10-17-43(64)54-37-16-12-15-35-36(37)30-62(50(35)69)40-21-22-44(65)56-49(40)68/h12,15-16,19-20,27-28,32,34,39-40H,4-11,13-14,17-18,21-26,29-30H2,1-3H3,(H,53,67)(H,54,64)(H,52,55,57)(H,56,65,68)/t39-,40?/m1/s1","DKPUPJUELCIYFX-IPVUVHESSA-N"
"2699","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","8.7","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.42","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","815.313","814.241242268","3.95","57","7","14","4","13","208.16","C38H39ClN10O7S","InChI=1S/C38H39ClN10O7S/c1-21-5-3-7-24(39)33(21)46-35(53)27-20-41-38(57-27)44-28-19-29(43-22(2)42-28)47-13-15-48(16-14-47)31(51)11-17-56-18-12-40-25-8-4-6-23-32(25)37(55)49(36(23)54)26-9-10-30(50)45-34(26)52/h3-8,19-20,26,40H,9-18H2,1-2H3,(H,46,53)(H,45,50,52)(H,41,42,43,44)","SZIZYLBRFVQQMV-UHFFFAOYSA-N"
"2700","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","17.5","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.05","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","859.366","858.267457016","3.8","60","7","15","4","16","217.39","C40H43ClN10O8S","InChI=1S/C40H43ClN10O8S/c1-23-5-3-7-26(41)35(23)48-37(55)29-22-43-40(60-29)46-30-21-31(45-24(2)44-30)49-13-15-50(16-14-49)33(53)11-17-58-19-20-59-18-12-42-27-8-4-6-25-34(27)39(57)51(38(25)56)28-9-10-32(52)47-36(28)54/h3-8,21-22,28,42H,9-20H2,1-2H3,(H,48,55)(H,47,52,54)(H,43,44,45,46)","PWEJVOFOTMSQSC-UHFFFAOYSA-N"
"2701","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","18.4","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14.75","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","903.419","902.293671764","3.66","63","7","16","4","19","226.62","C42H47ClN10O9S","InChI=1S/C42H47ClN10O9S/c1-25-5-3-7-28(43)37(25)50-39(57)31-24-45-42(63-31)48-32-23-33(47-26(2)46-32)51-13-15-52(16-14-51)35(55)11-17-60-19-21-62-22-20-61-18-12-44-29-8-4-6-27-36(29)41(59)53(40(27)58)30-9-10-34(54)49-38(30)56/h3-8,23-24,30,44H,9-22H2,1-2H3,(H,50,57)(H,49,54,56)(H,45,46,47,48)","KMYACHYBDVUSCP-UHFFFAOYSA-N"
"2702","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","26.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","40.4","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","947.472","946.319886512","3.51","66","7","17","4","22","235.85","C44H51ClN10O10S","InChI=1S/C44H51ClN10O10S/c1-27-5-3-7-30(45)39(27)52-41(59)33-26-47-44(66-33)50-34-25-35(49-28(2)48-34)53-13-15-54(16-14-53)37(57)11-17-62-19-21-64-23-24-65-22-20-63-18-12-46-31-8-4-6-29-38(31)43(61)55(42(29)60)32-9-10-36(56)51-40(32)58/h3-8,25-26,32,46H,9-24H2,1-2H3,(H,52,59)(H,51,56,58)(H,47,48,49,50)","UWFYRMKSZBLWRI-UHFFFAOYSA-N"
"2703","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","10.8","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31.9","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","991.525","990.34610126","3.36","69","7","18","4","25","245.08","C46H55ClN10O11S","InChI=1S/C46H55ClN10O11S/c1-29-5-3-7-32(47)41(29)54-43(61)35-28-49-46(69-35)52-36-27-37(51-30(2)50-36)55-13-15-56(16-14-55)39(59)11-17-64-19-21-66-23-25-68-26-24-67-22-20-65-18-12-48-33-8-4-6-31-40(33)45(63)57(44(31)62)34-9-10-38(58)53-42(34)60/h3-8,27-28,34,48H,9-26H2,1-2H3,(H,54,61)(H,53,58,60)(H,49,50,51,52)","SILFGWIHHRCURU-UHFFFAOYSA-N"
"2704","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","7.8","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.5","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","785.287","784.230677584","4.46","55","7","13","4","11","198.93","C37H37ClN10O6S","InChI=1S/C37H37ClN10O6S/c1-20-6-3-8-23(38)32(20)45-34(52)26-19-40-37(55-26)43-27-18-28(42-21(2)41-27)46-14-16-47(17-15-46)30(50)10-5-13-39-24-9-4-7-22-31(24)36(54)48(35(22)53)25-11-12-29(49)44-33(25)51/h3-4,6-9,18-19,25,39H,5,10-17H2,1-2H3,(H,45,52)(H,44,49,51)(H,40,41,42,43)","ULQMXQMXNOMYGN-UHFFFAOYSA-N"
"2705","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","11","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.55","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","799.314","798.246327648","4.81","56","7","13","4","12","198.93","C38H39ClN10O6S","InChI=1S/C38H39ClN10O6S/c1-21-7-5-9-24(39)33(21)46-35(53)27-20-41-38(56-27)44-28-19-29(43-22(2)42-28)47-15-17-48(18-16-47)31(51)11-3-4-14-40-25-10-6-8-23-32(25)37(55)49(36(23)54)26-12-13-30(50)45-34(26)52/h5-10,19-20,26,40H,3-4,11-18H2,1-2H3,(H,46,53)(H,45,50,52)(H,41,42,43,44)","AMMLOEMUGDHWEL-UHFFFAOYSA-N"
"2706","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","9","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.47","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","827.368","826.277627776","5.71","58","7","13","4","14","198.93","C40H43ClN10O6S","InChI=1S/C40H43ClN10O6S/c1-23-9-7-11-26(41)35(23)48-37(55)29-22-43-40(58-29)46-30-21-31(45-24(2)44-30)49-17-19-50(20-18-49)33(53)13-5-3-4-6-16-42-27-12-8-10-25-34(27)39(57)51(38(25)56)28-14-15-32(52)47-36(28)54/h7-12,21-22,28,42H,3-6,13-20H2,1-2H3,(H,48,55)(H,47,52,54)(H,43,44,45,46)","NUMLKLUMDIDGLZ-UHFFFAOYSA-N"
"2707","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","5.6","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.2","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","774.285","773.160549424","4.17","53","7","13","3","9","186.9","C35H32ClN9O6S2","InChI=1S/C35H32ClN9O6S2/c1-18-5-3-7-21(36)30(18)42-32(49)24-16-37-35(53-24)40-25-15-26(39-19(2)38-25)43-11-13-44(14-12-43)28(47)17-52-23-8-4-6-20-29(23)34(51)45(33(20)50)22-9-10-27(46)41-31(22)48/h3-8,15-16,22H,9-14,17H2,1-2H3,(H,42,49)(H,41,46,48)(H,37,38,39,40)","OJLCJVMCSVZIQZ-UHFFFAOYSA-N"
"2708","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","10","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.22","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","757.233","756.199377456","4.2","53","7","13","4","9","198.93","C35H33ClN10O6S","InChI=1S/C35H33ClN10O6S/c1-18-5-3-7-21(36)30(18)43-32(50)24-16-38-35(53-24)41-25-15-26(40-19(2)39-25)44-11-13-45(14-12-44)28(48)17-37-22-8-4-6-20-29(22)34(52)46(33(20)51)23-9-10-27(47)42-31(23)49/h3-8,15-16,23,37H,9-14,17H2,1-2H3,(H,43,50)(H,42,47,49)(H,38,39,40,41)","MFRLCRUPMVPIMD-UHFFFAOYSA-N"
"2709","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","11.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","758.217","757.183393044","3.63","53","7","13","3","9","196.13","C35H32ClN9O7S","InChI=1S/C35H32ClN9O7S/c1-18-5-3-7-21(36)30(18)42-32(49)24-16-37-35(53-24)40-25-15-26(39-19(2)38-25)43-11-13-44(14-12-43)28(47)17-52-23-8-4-6-20-29(23)34(51)45(33(20)50)22-9-10-27(46)41-31(22)48/h3-8,15-16,22H,9-14,17H2,1-2H3,(H,42,49)(H,41,46,48)(H,37,38,39,40)","NJRHGBYRTRXLKB-UHFFFAOYSA-N"
"2710","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","95.4","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.84","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","756.245","755.204128488","3.82","53","7","12","3","9","186.9","C36H34ClN9O6S","InChI=1S/C36H34ClN9O6S/c1-19-5-3-8-23(37)31(19)43-33(50)25-18-38-36(53-25)41-26-17-27(40-20(2)39-26)44-13-15-45(16-14-44)29(48)12-9-21-6-4-7-22-30(21)35(52)46(34(22)51)24-10-11-28(47)42-32(24)49/h3-8,17-18,24H,9-16H2,1-2H3,(H,43,50)(H,42,47,49)(H,38,39,40,41)","SXKYAXKGNXJHBH-UHFFFAOYSA-N"
"2711","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CS(=O)(=O)C3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","245.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","206","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","806.283","805.150378664","2.9","55","7","14","3","9","221.04","C35H32ClN9O8S2","InChI=1S/C35H32ClN9O8S2/c1-18-5-3-7-21(36)30(18)42-32(49)23-16-37-35(54-23)40-25-15-26(39-19(2)38-25)43-11-13-44(14-12-43)28(47)17-55(52,53)24-8-4-6-20-29(24)34(51)45(33(20)50)22-9-10-27(46)41-31(22)48/h3-8,15-16,22H,9-14,17H2,1-2H3,(H,42,49)(H,41,46,48)(H,37,38,39,40)","NMCQXYSUJSZTPX-UHFFFAOYSA-N"
"2712","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","0.18","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.49","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL G250E","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL E255V","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL V299L","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL F317L","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL F317V","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2712","","BCR-ABL T315A","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.68","52","7","13","3","10","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-22(36)30(19)42-32(48)25-18-37-35(52-25)40-26-17-27(39-20(2)38-26)44-13-11-43(12-14-44)15-16-51-24-8-4-6-21-29(24)34(50)45(33(21)49)23-9-10-28(46)41-31(23)47/h3-8,17-18,23H,9-16H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","QOGZTNFOSUHSAL-UHFFFAOYSA-N"
"2713","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CSC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)CC2)=N1","8.9","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.7","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","760.302","759.181284868","4.23","52","7","12","3","9","169.83","C35H34ClN9O5S2","InChI=1S/C35H34ClN9O5S2/c1-19-5-3-7-23(36)31(19)42-33(49)26-16-37-35(52-26)40-27-15-28(39-20(2)38-27)43-11-13-44(14-12-43)30(47)18-51-25-8-4-6-21-22(25)17-45(34(21)50)24-9-10-29(46)41-32(24)48/h3-8,15-16,24H,9-14,17-18H2,1-2H3,(H,42,49)(H,41,46,48)(H,37,38,39,40)","YPUFMWKOTXCGRO-UHFFFAOYSA-N"
"2714","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCSC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)CC2)=N1","2.7","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.51","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","746.319","745.202020312","4.74","51","7","12","3","10","152.76","C35H36ClN9O4S2","InChI=1S/C35H36ClN9O4S2/c1-20-5-3-7-24(36)31(20)42-33(48)27-18-37-35(51-27)40-28-17-29(39-21(2)38-28)44-13-11-43(12-14-44)15-16-50-26-8-4-6-22-23(26)19-45(34(22)49)25-9-10-30(46)41-32(25)47/h3-8,17-18,25H,9-16,19H2,1-2H3,(H,42,48)(H,41,46,47)(H,37,38,39,40)","TWBLQEUPMCWVSA-UHFFFAOYSA-N"
"2715","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","2.7","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.28","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","771.304","770.251413028","5.42","54","7","13","4","12","181.86","C37H39ClN10O5S","InChI=1S/C37H39ClN10O5S/c1-21-7-5-9-24(38)32(21)45-34(51)27-20-40-37(54-27)43-28-19-29(42-22(2)41-28)47-17-15-46(16-18-47)14-4-3-13-39-25-10-6-8-23-31(25)36(53)48(35(23)52)26-11-12-30(49)44-33(26)50/h5-10,19-20,26,39H,3-4,11-18H2,1-2H3,(H,45,51)(H,44,49,50)(H,40,41,42,43)","WXBNWDRYXKZBKS-UHFFFAOYSA-N"
"2716","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=N1","10.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.6","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","799.314","798.246327648","4.55","56","7","13","4","12","198.93","C38H39ClN10O6S","InChI=1S/C38H39ClN10O6S/c1-21-7-5-9-24(39)33(21)46-35(53)27-20-40-38(56-27)44-28-19-29(42-22(2)41-28)48-17-15-47(16-18-48)14-4-3-11-30(50)43-25-10-6-8-23-32(25)37(55)49(36(23)54)26-12-13-31(51)45-34(26)52/h5-10,19-20,26H,3-4,11-18H2,1-2H3,(H,43,50)(H,46,53)(H,45,51,52)(H,40,41,42,44)","ZHOVUHAPZWSGIE-UHFFFAOYSA-N"
"2717","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)CC2)=N1","11.1","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.2","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","785.331","784.267063092","4.32","55","7","12","4","12","181.86","C38H41ClN10O5S","InChI=1S/C38H41ClN10O5S/c1-22-7-5-9-26(39)34(22)46-36(53)29-20-41-38(55-29)44-30-19-31(43-23(2)42-30)47-15-17-48(18-16-47)33(51)11-3-4-14-40-27-10-6-8-24-25(27)21-49(37(24)54)28-12-13-32(50)45-35(28)52/h5-10,19-20,28,40H,3-4,11-18,21H2,1-2H3,(H,46,53)(H,45,50,52)(H,41,42,43,44)","TYAXRGVMSNZDCH-UHFFFAOYSA-N"
"2718","","BCR-ABL","CRBN","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(C(=O)CCCC(=O)NC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)CC2)=N1","125","","Degradation of BCR-ABL in K562 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.03","Inhibit proliferation of K562 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113645","799.314","798.246327648","3.09","56","7","12","4","11","198.93","C38H39ClN10O6S","InChI=1S/C38H39ClN10O6S/c1-21-6-3-8-25(39)34(21)46-36(54)28-19-40-38(56-28)44-29-18-30(42-22(2)41-29)47-14-16-48(17-15-47)33(52)11-5-10-31(50)43-26-9-4-7-23-24(26)20-49(37(23)55)27-12-13-32(51)45-35(27)53/h3-4,6-9,18-19,27H,5,10-17,20H2,1-2H3,(H,43,50)(H,46,54)(H,45,51,53)(H,40,41,42,44)","XEXXSHKPXLLHJH-UHFFFAOYSA-N"
"2719","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1980/20560","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","627.061","626.179293644","3.12","45","6","11","3","6","174.43","C31H27ClN8O5","InChI=1S/C31H27ClN8O5/c1-15-12-35-20(16(2)25(15)45-3)14-39-13-17(23-26(32)37-31(33)38-27(23)39)6-5-11-34-19-8-4-7-18-24(19)30(44)40(29(18)43)21-9-10-22(41)36-28(21)42/h4,7-8,12-13,21,34H,9-11,14H2,1-3H3,(H2,33,37,38)(H,36,41,42)","NXTCCFQDFANAQB-UHFFFAOYSA-N"
"2720","","HSP90","CRBN","","BP3","COC1=C(C)C=NC(CN2C=C(C#CCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","990","83.43","Degradation of HSP90 in MCF-7 cells after 6 h treatment","","","","","","","118000","BLI","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","630/3530","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","641.088","640.194943708","3.58","46","6","11","3","7","174.43","C32H29ClN8O5","InChI=1S/C32H29ClN8O5/c1-16-13-36-21(17(2)26(16)46-3)15-40-14-18(24-27(33)38-32(34)39-28(24)40)7-4-5-12-35-20-9-6-8-19-25(20)31(45)41(30(19)44)22-10-11-23(42)37-29(22)43/h6,8-9,13-14,22,35H,5,10-12,15H2,1-3H3,(H2,34,38,39)(H,37,42,43)","ZSERQSKFLSKTGE-UHFFFAOYSA-N"
"2721","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1450/5200","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","655.115","654.210593772","3.94","47","6","11","3","8","174.43","C33H31ClN8O5","InChI=1S/C33H31ClN8O5/c1-17-14-37-22(18(2)27(17)47-3)16-41-15-19(25-28(34)39-33(35)40-29(25)41)8-5-4-6-13-36-21-10-7-9-20-26(21)32(46)42(31(20)45)23-11-12-24(43)38-30(23)44/h7,9-10,14-15,23,36H,4,6,11-13,16H2,1-3H3,(H2,35,39,40)(H,38,43,44)","LPRRFBQMICZXQT-UHFFFAOYSA-N"
"2722","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","250/2200","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","669.142","668.226243836","4.29","48","6","11","3","9","174.43","C34H33ClN8O5","InChI=1S/C34H33ClN8O5/c1-18-15-38-23(19(2)28(18)48-3)17-42-16-20(26-29(35)40-34(36)41-30(26)42)9-6-4-5-7-14-37-22-11-8-10-21-27(22)33(47)43(32(21)46)24-12-13-25(44)39-31(24)45/h8,10-11,15-16,24,37H,4-5,7,12-14,17H2,1-3H3,(H2,36,40,41)(H,39,44,45)","DIRKTRKLANOCCM-UHFFFAOYSA-N"
"2723","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","190/440","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","671.114","670.205508392","2.97","48","6","12","3","9","183.66","C33H31ClN8O6","InChI=1S/C33H31ClN8O6/c1-17-14-37-22(18(2)27(17)47-3)16-41-15-19(25-28(34)39-33(35)40-29(25)41)6-5-12-48-13-11-36-21-8-4-7-20-26(21)32(46)42(31(20)45)23-9-10-24(43)38-30(23)44/h4,7-8,14-15,23,36H,9-13,16H2,1-3H3,(H2,35,39,40)(H,38,43,44)","GCJUYQBYOXMZJZ-UHFFFAOYSA-N"
"2724","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","980/760","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","715.167","714.23172314","2.82","51","6","13","3","12","192.89","C35H35ClN8O7","InChI=1S/C35H35ClN8O7/c1-19-16-39-24(20(2)29(19)49-3)18-43-17-21(27-30(36)41-35(37)42-31(27)43)6-5-12-50-14-15-51-13-11-38-23-8-4-7-22-28(23)34(48)44(33(22)47)25-9-10-26(45)40-32(25)46/h4,7-8,16-17,25,38H,9-15,18H2,1-3H3,(H2,37,41,42)(H,40,45,46)","SAYJCUWIIIWQSM-UHFFFAOYSA-N"
"2725","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2240/4850","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","759.22","758.257937888","2.67","54","6","14","3","15","202.12","C37H39ClN8O8","InChI=1S/C37H39ClN8O8/c1-21-18-41-26(22(2)31(21)51-3)20-45-19-23(29-32(38)43-37(39)44-33(29)45)6-5-12-52-14-16-54-17-15-53-13-11-40-25-8-4-7-24-30(25)36(50)46(35(24)49)27-9-10-28(47)42-34(27)48/h4,7-8,18-19,27,40H,9-17,20H2,1-3H3,(H2,39,43,44)(H,42,47,48)","PMOYYSKYIOXQNQ-UHFFFAOYSA-N"
"2726","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6120/9480","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","803.273","802.284152636","2.53","57","6","15","3","18","211.35","C39H43ClN8O9","InChI=1S/C39H43ClN8O9/c1-23-20-43-28(24(2)33(23)53-3)22-47-21-25(31-34(40)45-39(41)46-35(31)47)6-5-12-54-14-16-56-18-19-57-17-15-55-13-11-42-27-8-4-7-26-32(27)38(52)48(37(26)51)29-9-10-30(49)44-36(29)50/h4,7-8,20-21,29,42H,9-19,22H2,1-3H3,(H2,41,45,46)(H,44,49,50)","WPNSOZZOBPAEJK-UHFFFAOYSA-N"
"2727","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5630/3870","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","847.326","846.310367384","2.38","60","6","16","3","21","220.58","C41H47ClN8O10","InChI=1S/C41H47ClN8O10/c1-25-22-45-30(26(2)35(25)55-3)24-49-23-27(33-36(42)47-41(43)48-37(33)49)6-5-12-56-14-16-58-18-20-60-21-19-59-17-15-57-13-11-44-29-8-4-7-28-34(29)40(54)50(39(28)53)31-9-10-32(51)46-38(31)52/h4,7-8,22-23,31,44H,9-21,24H2,1-3H3,(H2,43,47,48)(H,46,51,52)","ZELWWSSYEIDJBV-UHFFFAOYSA-N"
"2728","","HSP90","CRBN","","","COC1=C(C)C=NC(CN2C=C(C#CCOCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C3=C(Cl)N=C(N)N=C32)=C1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3140/3880","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","891.379","890.336582132","2.23","63","6","17","3","24","229.81","C43H51ClN8O11","InChI=1S/C43H51ClN8O11/c1-27-24-47-32(28(2)37(27)57-3)26-51-25-29(35-38(44)49-43(45)50-39(35)51)6-5-12-58-14-16-60-18-20-62-22-23-63-21-19-61-17-15-59-13-11-46-31-8-4-7-30-36(31)42(56)52(41(30)55)33-9-10-34(53)48-40(33)54/h4,7-8,24-25,33,46H,9-23,26H2,1-3H3,(H2,45,49,50)(H,48,53,54)","ZCSPRVQFFGHDKB-UHFFFAOYSA-N"
"2729","","HSP90","MDM2","","","COC1=CC(C(=O)NCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20920/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","969.321","967.270640432","8.77","67","7","11","4","11","182.1","C49H46Cl3F2N9O4","InChI=1S/C49H46Cl3F2N9O4/c1-25-21-58-35(26(2)42(25)67-7)23-63-22-28(38-43(52)61-47(56)62-44(38)63)10-9-17-57-45(64)27-13-16-34(36(18-27)66-6)59-46(65)41-39(30-11-8-12-32(51)40(30)54)49(24-55,37(60-41)20-48(3,4)5)31-15-14-29(50)19-33(31)53/h8,11-16,18-19,21-22,37,39,41,60H,17,20,23H2,1-7H3,(H,57,64)(H,59,65)(H2,56,61,62)/t37-,39-,41+,49-/m0/s1","DZAUZQYCTJIQPC-CGAOLJTPSA-N"
"2730","","HSP90","MDM2","","","COC1=CC(C(=O)NCCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","37870/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","983.348","981.286290496","9.24","68","7","11","4","12","182.1","C50H48Cl3F2N9O4","InChI=1S/C50H48Cl3F2N9O4/c1-26-22-59-36(27(2)43(26)68-7)24-64-23-29(39-44(53)62-48(57)63-45(39)64)11-8-9-18-58-46(65)28-14-17-35(37(19-28)67-6)60-47(66)42-40(31-12-10-13-33(52)41(31)55)50(25-56,38(61-42)21-49(3,4)5)32-16-15-30(51)20-34(32)54/h10,12-17,19-20,22-23,38,40,42,61H,9,18,21,24H2,1-7H3,(H,58,65)(H,60,66)(H2,57,62,63)/t38-,40-,42+,50-/m0/s1","OBTVPVLTGRYAFU-OWUQSMTQSA-N"
"2731","","HSP90","MDM2","","","COC1=CC(C(=O)NCCCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","97300/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","997.375","995.30194056","9.59","69","7","11","4","13","182.1","C51H50Cl3F2N9O4","InChI=1S/C51H50Cl3F2N9O4/c1-27-23-60-37(28(2)44(27)69-7)25-65-24-30(40-45(54)63-49(58)64-46(40)65)12-9-8-10-19-59-47(66)29-15-18-36(38(20-29)68-6)61-48(67)43-41(32-13-11-14-34(53)42(32)56)51(26-57,39(62-43)22-50(3,4)5)33-17-16-31(52)21-35(33)55/h11,13-18,20-21,23-24,39,41,43,62H,8,10,19,22,25H2,1-7H3,(H,59,66)(H,61,67)(H2,58,63,64)/t39-,41-,43+,51-/m0/s1","IGHXOLIPTGHMGK-DHAXRJOVSA-N"
"2732","","HSP90","MDM2","","","COC1=CC(C(=O)NCCCCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1011.402","1009.31759062","9.95","70","7","11","4","14","182.1","C52H52Cl3F2N9O4","InChI=1S/C52H52Cl3F2N9O4/c1-28-24-61-38(29(2)45(28)70-7)26-66-25-31(41-46(55)64-50(59)65-47(41)66)13-10-8-9-11-20-60-48(67)30-16-19-37(39(21-30)69-6)62-49(68)44-42(33-14-12-15-35(54)43(33)57)52(27-58,40(63-44)23-51(3,4)5)34-18-17-32(53)22-36(34)56/h12,14-19,21-22,24-25,40,42,44,63H,8-9,11,20,23,26H2,1-7H3,(H,60,67)(H,62,68)(H2,59,64,65)/t40-,42-,44+,52-/m0/s1","YJZNIQDMBWWQCU-JDBBZIPESA-N"
"2733","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","71680/65900","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1013.374","1011.29685518","8.63","70","7","12","4","14","191.33","C51H50Cl3F2N9O5","InChI=1S/C51H50Cl3F2N9O5/c1-27-23-60-37(28(2)44(27)69-7)25-65-24-30(40-45(54)63-49(58)64-46(40)65)10-9-18-70-19-17-59-47(66)29-13-16-36(38(20-29)68-6)61-48(67)43-41(32-11-8-12-34(53)42(32)56)51(26-57,39(62-43)22-50(3,4)5)33-15-14-31(52)21-35(33)55/h8,11-16,20-21,23-24,39,41,43,62H,17-19,22,25H2,1-7H3,(H,59,66)(H,61,67)(H2,58,63,64)/t39-,41-,43+,51-/m0/s1","YFCNFGBVSUKDGB-DHAXRJOVSA-N"
"2734","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32920/72130","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1057.427","1055.32306993","8.48","73","7","13","4","17","200.56","C53H54Cl3F2N9O6","InChI=1S/C53H54Cl3F2N9O6/c1-29-25-62-39(30(2)46(29)71-7)27-67-26-32(42-47(56)65-51(60)66-48(42)67)10-9-18-72-20-21-73-19-17-61-49(68)31-13-16-38(40(22-31)70-6)63-50(69)45-43(34-11-8-12-36(55)44(34)58)53(28-59,41(64-45)24-52(3,4)5)35-15-14-33(54)23-37(35)57/h8,11-16,22-23,25-26,41,43,45,64H,17-21,24,27H2,1-7H3,(H,61,68)(H,63,69)(H2,60,65,66)/t41-,43-,45+,53-/m0/s1","SWWABGIYWRRIDX-WVVAHTLVSA-N"
"2735","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1101.48","1099.34928468","8.33","76","7","14","4","20","209.79","C55H58Cl3F2N9O7","InChI=1S/C55H58Cl3F2N9O7/c1-31-27-64-41(32(2)48(31)73-7)29-69-28-34(44-49(58)67-53(62)68-50(44)69)10-9-18-74-20-22-76-23-21-75-19-17-63-51(70)33-13-16-40(42(24-33)72-6)65-52(71)47-45(36-11-8-12-38(57)46(36)60)55(30-61,43(66-47)26-54(3,4)5)37-15-14-35(56)25-39(37)59/h8,11-16,24-25,27-28,43,45,47,66H,17-23,26,29H2,1-7H3,(H,63,70)(H,65,71)(H2,62,67,68)/t43-,45-,47+,55-/m0/s1","LTJHZMMOMQLXCP-CRXZALTNSA-N"
"2736","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1145.533","1143.37549942","8.18","79","7","15","4","23","219.02","C57H62Cl3F2N9O8","InChI=1S/C57H62Cl3F2N9O8/c1-33-29-66-43(34(2)50(33)75-7)31-71-30-36(46-51(60)69-55(64)70-52(46)71)10-9-18-76-20-22-78-24-25-79-23-21-77-19-17-65-53(72)35-13-16-42(44(26-35)74-6)67-54(73)49-47(38-11-8-12-40(59)48(38)62)57(32-63,45(68-49)28-56(3,4)5)39-15-14-37(58)27-41(39)61/h8,11-16,26-27,29-30,45,47,49,68H,17-25,28,31H2,1-7H3,(H,65,72)(H,67,73)(H2,64,69,70)/t45-,47-,49+,57-/m0/s1","DJHOQUDEEDRKGV-TZHZUZLSSA-N"
"2737","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCCOCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1189.586","1187.40171417","8.04","82","7","16","4","26","228.25","C59H66Cl3F2N9O9","InChI=1S/C59H66Cl3F2N9O9/c1-35-31-68-45(36(2)52(35)77-7)33-73-32-38(48-53(62)71-57(66)72-54(48)73)10-9-18-78-20-22-80-24-26-82-27-25-81-23-21-79-19-17-67-55(74)37-13-16-44(46(28-37)76-6)69-56(75)51-49(40-11-8-12-42(61)50(40)64)59(34-65,47(70-51)30-58(3,4)5)41-15-14-39(60)29-43(41)63/h8,11-16,28-29,31-32,47,49,51,70H,17-27,30,33H2,1-7H3,(H,67,74)(H,69,75)(H2,66,71,72)/t47-,49-,51+,59-/m0/s1","OCRCQOMXXAXBPU-ZSXNONCVSA-N"
"2738","","HSP90","MDM2","","","COC1=CC(C(=O)NCCOCCOCCOCCOCCOCCOCC#CC2=CN(CC3=NC=C(C)C(OC)=C3C)C3=NC(N)=NC(Cl)=C23)=CC=C1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C1=CC=CC(Cl)=C1F","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/>100000","Inhibit growth of MCF-7/MDA-MB-231 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114013","1233.639","1231.42792892","7.89","85","7","17","4","29","237.48","C61H70Cl3F2N9O10","InChI=1S/C61H70Cl3F2N9O10/c1-37-33-70-47(38(2)54(37)79-7)35-75-34-40(50-55(64)73-59(68)74-56(50)75)10-9-18-80-20-22-82-24-26-84-28-29-85-27-25-83-23-21-81-19-17-69-57(76)39-13-16-46(48(30-39)78-6)71-58(77)53-51(42-11-8-12-44(63)52(42)66)61(36-67,49(72-53)32-60(3,4)5)43-15-14-41(62)31-45(43)65/h8,11-16,30-31,33-34,49,51,53,72H,17-29,32,35H2,1-7H3,(H,69,76)(H,71,77)(H2,68,73,74)/t49-,51-,53+,61-/m0/s1","IXVMOOAGVAOLJI-GAAPXUGQSA-N"
"2739","Q9NYV4","CDK12","CRBN","","PP-C6","CC(C)N1C=NC2=C(NCC3=NC4=CC(F)=C(NCCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4[NH]3)N=C(N3CCOCC3)N=C21","","","","","","119.7","Inhibition of CDK12/cyclinK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114012","838.902","838.367470064","2.98","61","8","15","5","17","230.69","C41H47FN12O7","InChI=1S/C41H47FN12O7/c1-23(2)53-22-46-35-36(50-41(51-37(35)53)52-14-16-60-17-15-52)45-20-31-47-27-18-25(42)26(19-28(27)48-31)43-12-5-3-4-6-13-44-33(56)21-61-30-9-7-8-24-34(30)40(59)54(39(24)58)29-10-11-32(55)49-38(29)57/h7-9,18-19,22-23,29,43H,3-6,10-17,20-21H2,1-2H3,(H,44,56)(H,47,48)(H,45,50,51)(H,49,55,57)","DKHFQORSZZALIY-UHFFFAOYSA-N"
"2740","Q9NYV4","CDK12","CRBN","","PP-C8","CC(C)N1C=NC2=C(NCC3=NC4=CC(F)=C(NCCCCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4[NH]3)N=C(N3CCOCC3)N=C21","416/412","","Degradation of CDK12 in Bel-7402/MDA-MB-231 cells after 24 h treatment","","","645.4","Inhibition of CDK12/cyclinK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114012","866.956","866.398770192","4.06","63","8","15","5","19","230.69","C43H51FN12O7","InChI=1S/C43H51FN12O7/c1-25(2)55-24-48-37-38(52-43(53-39(37)55)54-16-18-62-19-17-54)47-22-33-49-29-20-27(44)28(21-30(29)50-33)45-14-7-5-3-4-6-8-15-46-35(58)23-63-32-11-9-10-26-36(32)42(61)56(41(26)60)31-12-13-34(57)51-40(31)59/h9-11,20-21,24-25,31,45H,3-8,12-19,22-23H2,1-2H3,(H,46,58)(H,49,50)(H,47,52,53)(H,51,57,59)","XZMGOWQHLJWQJN-UHFFFAOYSA-N"
"2741","Q9NYV4","CDK12","CRBN","","PP-C10","CC(C)N1C=NC2=C(NCC3=NC4=CC(F)=C(NCCCCCCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4[NH]3)N=C(N3CCOCC3)N=C21","","","","","","1923.8","Inhibition of CDK12/cyclinK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114012","895.01","894.43007032","5.15","65","8","15","5","21","230.69","C45H55FN12O7","InChI=1S/C45H55FN12O7/c1-27(2)57-26-50-39-40(54-45(55-41(39)57)56-18-20-64-21-19-56)49-24-35-51-31-22-29(46)30(23-32(31)52-35)47-16-9-7-5-3-4-6-8-10-17-48-37(60)25-65-34-13-11-12-28-38(34)44(63)58(43(28)62)33-14-15-36(59)53-42(33)61/h11-13,22-23,26-27,33,47H,3-10,14-21,24-25H2,1-2H3,(H,48,60)(H,51,52)(H,49,54,55)(H,53,59,61)","NKPHVUBPIOSUEX-UHFFFAOYSA-N"
"2742","Q9NYV4","CDK12","CRBN","","PP-C12","CC(C)N1C=NC2=C(NCC3=NC4=CC(F)=C(NCCCCCCCCCCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4[NH]3)N=C(N3CCOCC3)N=C21","","","","","",">3000","Inhibition of CDK12/cyclinK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114012","923.064","922.461370448","6.23","67","8","15","5","23","230.69","C47H59FN12O7","InChI=1S/C47H59FN12O7/c1-29(2)59-28-52-41-42(56-47(57-43(41)59)58-20-22-66-23-21-58)51-26-37-53-33-24-31(48)32(25-34(33)54-37)49-18-11-9-7-5-3-4-6-8-10-12-19-50-39(62)27-67-36-15-13-14-30-40(36)46(65)60(45(30)64)35-16-17-38(61)55-44(35)63/h13-15,24-25,28-29,35,49H,3-12,16-23,26-27H2,1-2H3,(H,50,62)(H,53,54)(H,51,56,57)(H,55,61,63)","XFQJVHJSHJOCAP-UHFFFAOYSA-N"
"2743","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCNC(=O)CNC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","<5/0","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","995.093","994.386804928","-1.22","71","8","19","5","23","300.42","C46H54N14O10S","InChI=1S/C46H54N14O10S/c47-43-42(45(64)52-32-3-2-12-48-25-32)53-38(26-51-43)31-6-8-34(9-7-31)71(66,67)59-16-14-57(15-17-59)28-33-29-58(56-55-33)18-20-69-22-24-70-23-21-68-19-13-49-41(62)27-50-37-5-1-4-35-36(37)30-60(46(35)65)39-10-11-40(61)54-44(39)63/h1-9,12,25-26,29,39,50H,10-11,13-24,27-28,30H2,(H2,47,51)(H,49,62)(H,52,64)(H,54,61,63)","LBFRBZBJTSKGIW-UHFFFAOYSA-N"
"2743","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCNC(=O)CNC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","<5/0","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","995.093","994.386804928","-1.22","71","8","19","5","23","300.42","C46H54N14O10S","InChI=1S/C46H54N14O10S/c47-43-42(45(64)52-32-3-2-12-48-25-32)53-38(26-51-43)31-6-8-34(9-7-31)71(66,67)59-16-14-57(15-17-59)28-33-29-58(56-55-33)18-20-69-22-24-70-23-21-68-19-13-49-41(62)27-50-37-5-1-4-35-36(37)30-60(46(35)65)39-10-11-40(61)54-44(39)63/h1-9,12,25-26,29,39,50H,10-11,13-24,27-28,30H2,(H2,47,51)(H,49,62)(H,52,64)(H,54,61,63)","LBFRBZBJTSKGIW-UHFFFAOYSA-N"
"2744","P49840","GSK3A","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCNC(=O)CNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1Cl","","","","<5/<5","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","836.303","835.305616352","1.1","59","6","15","4","23","230.37","C39H46ClN9O10","InChI=1S/C39H46ClN9O10/c1-55-32-9-7-25(20-29(32)40)36-35(44-24-59-36)38(53)42-11-3-4-26-22-48(47-46-26)13-15-57-17-19-58-18-16-56-14-12-41-34(51)21-43-30-6-2-5-27-28(30)23-49(39(27)54)31-8-10-33(50)45-37(31)52/h2,5-7,9,20,22,24,31,43H,3-4,8,10-19,21,23H2,1H3,(H,41,51)(H,42,53)(H,45,50,52)","GAEXVYPDSWYWEL-UHFFFAOYSA-N"
"2744","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCNC(=O)CNC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1Cl","","","","<5/35.8","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","836.303","835.305616352","1.1","59","6","15","4","23","230.37","C39H46ClN9O10","InChI=1S/C39H46ClN9O10/c1-55-32-9-7-25(20-29(32)40)36-35(44-24-59-36)38(53)42-11-3-4-26-22-48(47-46-26)13-15-57-17-19-58-18-16-56-14-12-41-34(51)21-43-30-6-2-5-27-28(30)23-49(39(27)54)31-8-10-33(50)45-37(31)52/h2,5-7,9,20,22,24,31,43H,3-4,8,10-19,21,23H2,1H3,(H,41,51)(H,42,53)(H,45,50,52)","GAEXVYPDSWYWEL-UHFFFAOYSA-N"
"2745","P49840","GSK3A","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(COCCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1Cl","","","","38.7/76.4","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","780.191","779.231782716","1.22","55","6","15","2","20","215.54","C36H38ClN7O11","InChI=1S/C36H38ClN7O11/c1-50-27-8-6-22(18-25(27)37)32-31(39-21-55-32)34(47)38-10-3-11-43-19-23(41-42-43)20-53-15-14-51-12-13-52-16-17-54-28-5-2-4-24-30(28)36(49)44(35(24)48)26-7-9-29(45)40-33(26)46/h2,4-6,8,18-19,21,26H,3,7,9-17,20H2,1H3,(H,38,47)(H,40,45,46)","LQWQMXZHKPRTOM-UHFFFAOYSA-N"
"2745","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(COCCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1Cl","","","","14.5/37.3","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","780.191","779.231782716","1.22","55","6","15","2","20","215.54","C36H38ClN7O11","InChI=1S/C36H38ClN7O11/c1-50-27-8-6-22(18-25(27)37)32-31(39-21-55-32)34(47)38-10-3-11-43-19-23(41-42-43)20-53-15-14-51-12-13-52-16-17-54-28-5-2-4-24-30(28)36(49)44(35(24)48)26-7-9-29(45)40-33(26)46/h2,4-6,8,18-19,21,26H,3,7,9-17,20H2,1H3,(H,38,47)(H,40,45,46)","LQWQMXZHKPRTOM-UHFFFAOYSA-N"
"2746","P49840","GSK3A","VHL","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(CCCCC(=O)N[C@@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)N=N3)N=CO2)C=C1Cl","","","","<5/<5","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","874.465","873.339893684","4.99","61","6","13","4","18","206.7","C43H52ClN9O7S","InChI=1S/C43H52ClN9O7S/c1-26-38(61-25-48-26)28-13-11-27(12-14-28)21-46-40(56)33-20-31(54)23-53(33)42(58)39(43(2,3)4)49-35(55)10-7-6-9-30-22-52(51-50-30)18-8-17-45-41(57)36-37(60-24-47-36)29-15-16-34(59-5)32(44)19-29/h11-16,19,22,24-25,31,33,39,54H,6-10,17-18,20-21,23H2,1-5H3,(H,45,57)(H,46,56)(H,49,55)/t31-,33+,39+/m1/s1","YLHOZWVXEUSDRF-HDDZQQAMSA-N"
"2746","P49841","GSK-3beta","VHL","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(CCCCC(=O)N[C@@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)N=N3)N=CO2)C=C1Cl","","","","<5/<5","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","874.465","873.339893684","4.99","61","6","13","4","18","206.7","C43H52ClN9O7S","InChI=1S/C43H52ClN9O7S/c1-26-38(61-25-48-26)28-13-11-27(12-14-28)21-46-40(56)33-20-31(54)23-53(33)42(58)39(43(2,3)4)49-35(55)10-7-6-9-30-22-52(51-50-30)18-8-17-45-41(57)36-37(60-24-47-36)29-15-16-34(59-5)32(44)19-29/h11-16,19,22,24-25,31,33,39,54H,6-10,17-18,20-21,23H2,1-5H3,(H,45,57)(H,46,56)(H,49,55)/t31-,33+,39+/m1/s1","YLHOZWVXEUSDRF-HDDZQQAMSA-N"
"2747","P49840","GSK3A","VHL","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(COCCOCCOCCOCC(=O)N[C@@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)N=N3)N=CO2)C=C1Cl","","","","<5/<5","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","994.569","993.38215242","3.32","69","6","17","4","26","243.62","C47H60ClN9O11S","InChI=1S/C47H60ClN9O11S/c1-30-42(69-29-52-30)32-9-7-31(8-10-32)23-50-44(60)37-22-35(58)25-57(37)46(62)43(47(2,3)4)53-39(59)27-67-20-18-65-16-15-64-17-19-66-26-34-24-56(55-54-34)14-6-13-49-45(61)40-41(68-28-51-40)33-11-12-38(63-5)36(48)21-33/h7-12,21,24,28-29,35,37,43,58H,6,13-20,22-23,25-27H2,1-5H3,(H,49,61)(H,50,60)(H,53,59)/t35-,37+,43+/m1/s1","UGFBBKMBFHLSDU-FWTUAJOASA-N"
"2747","P49841","GSK-3beta","VHL","","","COC1=CC=C(C2=C(C(=O)NCCCN3C=C(COCCOCCOCCOCC(=O)N[C@@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)N=N3)N=CO2)C=C1Cl","","","","<5/<5","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","994.569","993.38215242","3.32","69","6","17","4","26","243.62","C47H60ClN9O11S","InChI=1S/C47H60ClN9O11S/c1-30-42(69-29-52-30)32-9-7-31(8-10-32)23-50-44(60)37-22-35(58)25-57(37)46(62)43(47(2,3)4)53-39(59)27-67-20-18-65-16-15-64-17-19-66-26-34-24-56(55-54-34)14-6-13-49-45(61)40-41(68-28-51-40)33-11-12-38(63-5)36(48)21-33/h7-12,21,24,28-29,35,37,43,58H,6,13-20,22-23,25-27H2,1-5H3,(H,49,61)(H,50,60)(H,53,59)/t35-,37+,43+/m1/s1","UGFBBKMBFHLSDU-FWTUAJOASA-N"
"2748","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","46.9/68.9","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","907.971","907.31839102","0.08","65","8","18","4","18","279.16","C42H45N13O9S","InChI=1S/C42H45N13O9S/c43-38-37(40(58)47-28-3-2-12-44-23-28)48-33(24-46-38)27-6-8-30(9-7-27)65(61,62)54-16-14-52(15-17-54)25-29-26-53(51-50-29)18-20-64-22-21-63-19-13-45-32-5-1-4-31-36(32)42(60)55(41(31)59)34-10-11-35(56)49-39(34)57/h1-9,12,23-24,26,34,45H,10-11,13-22,25H2,(H2,43,46)(H,47,58)(H,49,56,57)","NPHVGHZMOBTTNX-UHFFFAOYSA-N"
"2748","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","30.5/39.6","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","907.971","907.31839102","0.08","65","8","18","4","18","279.16","C42H45N13O9S","InChI=1S/C42H45N13O9S/c43-38-37(40(58)47-28-3-2-12-44-23-28)48-33(24-46-38)27-6-8-30(9-7-27)65(61,62)54-16-14-52(15-17-54)25-29-26-53(51-50-29)18-20-64-22-21-63-19-13-45-32-5-1-4-31-36(32)42(60)55(41(31)59)34-10-11-35(56)49-39(34)57/h1-9,12,23-24,26,34,45H,10-11,13-22,25H2,(H2,43,46)(H,47,58)(H,49,56,57)","NPHVGHZMOBTTNX-UHFFFAOYSA-N"
"2749","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","45.4/75.6","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","952.024","951.344605768","-0.07","68","8","19","4","21","288.39","C44H49N13O10S","InChI=1S/C44H49N13O10S/c45-40-39(42(60)49-30-3-2-12-46-25-30)50-35(26-48-40)29-6-8-32(9-7-29)68(63,64)56-16-14-54(15-17-56)27-31-28-55(53-52-31)18-20-66-22-24-67-23-21-65-19-13-47-34-5-1-4-33-38(34)44(62)57(43(33)61)36-10-11-37(58)51-41(36)59/h1-9,12,25-26,28,36,47H,10-11,13-24,27H2,(H2,45,48)(H,49,60)(H,51,58,59)","RCVAZYOLQQIQJE-UHFFFAOYSA-N"
"2749","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","29.9/46.6","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","952.024","951.344605768","-0.07","68","8","19","4","21","288.39","C44H49N13O10S","InChI=1S/C44H49N13O10S/c45-40-39(42(60)49-30-3-2-12-46-25-30)50-35(26-48-40)29-6-8-32(9-7-29)68(63,64)56-16-14-54(15-17-56)27-31-28-55(53-52-31)18-20-66-22-24-67-23-21-65-19-13-47-34-5-1-4-33-38(34)44(62)57(43(33)61)36-10-11-37(58)51-41(36)59/h1-9,12,25-26,28,36,47H,10-11,13-24,27H2,(H2,45,48)(H,49,60)(H,51,58,59)","RCVAZYOLQQIQJE-UHFFFAOYSA-N"
"2750","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","42.0/79.5","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","996.077","995.370820516","-0.22","71","8","20","4","24","297.62","C46H53N13O11S","InChI=1S/C46H53N13O11S/c47-42-41(44(62)51-32-3-2-12-48-27-32)52-37(28-50-42)31-6-8-34(9-7-31)71(65,66)58-16-14-56(15-17-58)29-33-30-57(55-54-33)18-20-68-22-24-70-26-25-69-23-21-67-19-13-49-36-5-1-4-35-40(36)46(64)59(45(35)63)38-10-11-39(60)53-43(38)61/h1-9,12,27-28,30,38,49H,10-11,13-26,29H2,(H2,47,50)(H,51,62)(H,53,60,61)","DDQDFURXLHREJI-UHFFFAOYSA-N"
"2750","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","25.7/65","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","996.077","995.370820516","-0.22","71","8","20","4","24","297.62","C46H53N13O11S","InChI=1S/C46H53N13O11S/c47-42-41(44(62)51-32-3-2-12-48-27-32)52-37(28-50-42)31-6-8-34(9-7-31)71(65,66)58-16-14-56(15-17-58)29-33-30-57(55-54-33)18-20-68-22-24-70-26-25-69-23-21-67-19-13-49-36-5-1-4-35-40(36)46(64)59(45(35)63)38-10-11-39(60)53-43(38)61/h1-9,12,27-28,30,38,49H,10-11,13-26,29H2,(H2,47,50)(H,51,62)(H,53,60,61)","DDQDFURXLHREJI-UHFFFAOYSA-N"
"2751","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","47.4/77.2","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1040.13","1039.39703526","-0.37","74","8","21","4","27","306.85","C48H57N13O12S","InChI=1S/C48H57N13O12S/c49-44-43(46(64)53-34-3-2-12-50-29-34)54-39(30-52-44)33-6-8-36(9-7-33)74(67,68)60-16-14-58(15-17-60)31-35-32-59(57-56-35)18-20-70-22-24-72-26-28-73-27-25-71-23-21-69-19-13-51-38-5-1-4-37-42(38)48(66)61(47(37)65)40-10-11-41(62)55-45(40)63/h1-9,12,29-30,32,40,51H,10-11,13-28,31H2,(H2,49,52)(H,53,64)(H,55,62,63)","ALKXFMAFDABCFF-UHFFFAOYSA-N"
"2751","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","28.9/63.8","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1040.13","1039.39703526","-0.37","74","8","21","4","27","306.85","C48H57N13O12S","InChI=1S/C48H57N13O12S/c49-44-43(46(64)53-34-3-2-12-50-29-34)54-39(30-52-44)33-6-8-36(9-7-33)74(67,68)60-16-14-58(15-17-60)31-35-32-59(57-56-35)18-20-70-22-24-72-26-28-73-27-25-71-23-21-69-19-13-51-38-5-1-4-37-42(38)48(66)61(47(37)65)40-10-11-41(62)55-45(40)63/h1-9,12,29-30,32,40,51H,10-11,13-28,31H2,(H2,49,52)(H,53,64)(H,55,62,63)","ALKXFMAFDABCFF-UHFFFAOYSA-N"
"2752","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","29.7/75.4","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1084.183","1083.42325001","-0.51","77","8","22","4","30","316.08","C50H61N13O13S","InChI=1S/C50H61N13O13S/c51-46-45(48(66)55-36-3-2-12-52-31-36)56-41(32-54-46)35-6-8-38(9-7-35)77(69,70)62-16-14-60(15-17-62)33-37-34-61(59-58-37)18-20-72-22-24-74-26-28-76-30-29-75-27-25-73-23-21-71-19-13-53-40-5-1-4-39-44(40)50(68)63(49(39)67)42-10-11-43(64)57-47(42)65/h1-9,12,31-32,34,42,53H,10-11,13-30,33H2,(H2,51,54)(H,55,66)(H,57,64,65)","QVFPGOOSKWKGHK-UHFFFAOYSA-N"
"2752","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CC4=CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","15.2/61.3","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1084.183","1083.42325001","-0.51","77","8","22","4","30","316.08","C50H61N13O13S","InChI=1S/C50H61N13O13S/c51-46-45(48(66)55-36-3-2-12-52-31-36)56-41(32-54-46)35-6-8-38(9-7-35)77(69,70)62-16-14-60(15-17-62)33-37-34-61(59-58-37)18-20-72-22-24-74-26-28-76-30-29-75-27-25-73-23-21-71-19-13-53-40-5-1-4-39-44(40)50(68)63(49(39)67)42-10-11-43(64)57-47(42)65/h1-9,12,31-32,34,42,53H,10-11,13-30,33H2,(H2,51,54)(H,55,66)(H,57,64,65)","QVFPGOOSKWKGHK-UHFFFAOYSA-N"
"2753","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","61.1/95.2","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","921.998","921.334041084","0.54","66","8","18","4","19","279.16","C43H47N13O9S","InChI=1S/C43H47N13O9S/c44-39-38(41(59)48-29-3-2-13-45-25-29)49-34(26-47-39)28-6-8-31(9-7-28)66(62,63)55-18-16-53(17-19-55)15-12-30-27-54(52-51-30)20-22-65-24-23-64-21-14-46-33-5-1-4-32-37(33)43(61)56(42(32)60)35-10-11-36(57)50-40(35)58/h1-9,13,25-27,35,46H,10-12,14-24H2,(H2,44,47)(H,48,59)(H,50,57,58)","NPUQFBMJXLMXKF-UHFFFAOYSA-N"
"2753","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","41.9/79.5","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","921.998","921.334041084","0.54","66","8","18","4","19","279.16","C43H47N13O9S","InChI=1S/C43H47N13O9S/c44-39-38(41(59)48-29-3-2-13-45-25-29)49-34(26-47-39)28-6-8-31(9-7-28)66(62,63)55-18-16-53(17-19-55)15-12-30-27-54(52-51-30)20-22-65-24-23-64-21-14-46-33-5-1-4-32-37(33)43(61)56(42(32)60)35-10-11-36(57)50-40(35)58/h1-9,13,25-27,35,46H,10-12,14-24H2,(H2,44,47)(H,48,59)(H,50,57,58)","NPUQFBMJXLMXKF-UHFFFAOYSA-N"
"2754","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","65.0/90.7","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","966.051","965.360255832","0.39","69","8","19","4","22","288.39","C45H51N13O10S","InChI=1S/C45H51N13O10S/c46-41-40(43(61)50-31-3-2-13-47-27-31)51-36(28-49-41)30-6-8-33(9-7-30)69(64,65)57-18-16-55(17-19-57)15-12-32-29-56(54-53-32)20-22-67-24-26-68-25-23-66-21-14-48-35-5-1-4-34-39(35)45(63)58(44(34)62)37-10-11-38(59)52-42(37)60/h1-9,13,27-29,37,48H,10-12,14-26H2,(H2,46,49)(H,50,61)(H,52,59,60)","UUYDOKHIGLKZEB-UHFFFAOYSA-N"
"2754","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","51.6/79.1","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","966.051","965.360255832","0.39","69","8","19","4","22","288.39","C45H51N13O10S","InChI=1S/C45H51N13O10S/c46-41-40(43(61)50-31-3-2-13-47-27-31)51-36(28-49-41)30-6-8-33(9-7-30)69(64,65)57-18-16-55(17-19-57)15-12-32-29-56(54-53-32)20-22-67-24-26-68-25-23-66-21-14-48-35-5-1-4-34-39(35)45(63)58(44(34)62)37-10-11-38(59)52-42(37)60/h1-9,13,27-29,37,48H,10-12,14-26H2,(H2,46,49)(H,50,61)(H,52,59,60)","UUYDOKHIGLKZEB-UHFFFAOYSA-N"
"2755","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","63.8/91.8","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1010.104","1009.38647058","0.24","72","8","20","4","25","297.62","C47H55N13O11S","InChI=1S/C47H55N13O11S/c48-43-42(45(63)52-33-3-2-13-49-29-33)53-38(30-51-43)32-6-8-35(9-7-32)72(66,67)59-18-16-57(17-19-59)15-12-34-31-58(56-55-34)20-22-69-24-26-71-28-27-70-25-23-68-21-14-50-37-5-1-4-36-41(37)47(65)60(46(36)64)39-10-11-40(61)54-44(39)62/h1-9,13,29-31,39,50H,10-12,14-28H2,(H2,48,51)(H,52,63)(H,54,61,62)","PHKJXNMSYVMZFD-UHFFFAOYSA-N"
"2755","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","55.9/83.1","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1010.104","1009.38647058","0.24","72","8","20","4","25","297.62","C47H55N13O11S","InChI=1S/C47H55N13O11S/c48-43-42(45(63)52-33-3-2-13-49-29-33)53-38(30-51-43)32-6-8-35(9-7-32)72(66,67)59-18-16-57(17-19-59)15-12-34-31-58(56-55-34)20-22-69-24-26-71-28-27-70-25-23-68-21-14-50-37-5-1-4-36-41(37)47(65)60(46(36)64)39-10-11-40(61)54-44(39)62/h1-9,13,29-31,39,50H,10-12,14-28H2,(H2,48,51)(H,52,63)(H,54,61,62)","PHKJXNMSYVMZFD-UHFFFAOYSA-N"
"2756","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","68.1/87.8","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1054.157","1053.41268533","0.1","75","8","21","4","28","306.85","C49H59N13O12S","InChI=1S/C49H59N13O12S/c50-45-44(47(65)54-35-3-2-13-51-31-35)55-40(32-53-45)34-6-8-37(9-7-34)75(68,69)61-18-16-59(17-19-61)15-12-36-33-60(58-57-36)20-22-71-24-26-73-28-30-74-29-27-72-25-23-70-21-14-52-39-5-1-4-38-43(39)49(67)62(48(38)66)41-10-11-42(63)56-46(41)64/h1-9,13,31-33,41,52H,10-12,14-30H2,(H2,50,53)(H,54,65)(H,56,63,64)","YSSYSNAJBZMOSQ-UHFFFAOYSA-N"
"2756","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","61.6/81.3","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1054.157","1053.41268533","0.1","75","8","21","4","28","306.85","C49H59N13O12S","InChI=1S/C49H59N13O12S/c50-45-44(47(65)54-35-3-2-13-51-31-35)55-40(32-53-45)34-6-8-37(9-7-34)75(68,69)61-18-16-59(17-19-61)15-12-36-33-60(58-57-36)20-22-71-24-26-73-28-30-74-29-27-72-25-23-70-21-14-52-39-5-1-4-38-43(39)49(67)62(48(38)66)41-10-11-42(63)56-46(41)64/h1-9,13,31-33,41,52H,10-12,14-30H2,(H2,50,53)(H,54,65)(H,56,63,64)","YSSYSNAJBZMOSQ-UHFFFAOYSA-N"
"2757","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","66.3/93.9","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1098.21","1097.43890008","-0.05","78","8","22","4","31","316.08","C51H63N13O13S","InChI=1S/C51H63N13O13S/c52-47-46(49(67)56-37-3-2-13-53-33-37)57-42(34-55-47)36-6-8-39(9-7-36)78(70,71)63-18-16-61(17-19-63)15-12-38-35-62(60-59-38)20-22-73-24-26-75-28-30-77-32-31-76-29-27-74-25-23-72-21-14-54-41-5-1-4-40-45(41)51(69)64(50(40)68)43-10-11-44(65)58-48(43)66/h1-9,13,33-35,43,54H,10-12,14-32H2,(H2,52,55)(H,56,67)(H,58,65,66)","JJGALSSJVYZYHC-UHFFFAOYSA-N"
"2757","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCC4=CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","55.9/86","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1098.21","1097.43890008","-0.05","78","8","22","4","31","316.08","C51H63N13O13S","InChI=1S/C51H63N13O13S/c52-47-46(49(67)56-37-3-2-13-53-33-37)57-42(34-55-47)36-6-8-39(9-7-36)78(70,71)63-18-16-61(17-19-63)15-12-38-35-62(60-59-38)20-22-73-24-26-75-28-30-77-32-31-76-29-27-74-25-23-72-21-14-54-41-5-1-4-40-45(41)51(69)64(50(40)68)43-10-11-44(65)58-48(43)66/h1-9,13,33-35,43,54H,10-12,14-32H2,(H2,52,55)(H,56,67)(H,58,65,66)","JJGALSSJVYZYHC-UHFFFAOYSA-N"
"2758","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","70.9/95.1","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","950.052","949.365341212","1.25","68","8","18","4","21","279.16","C45H51N13O9S","InChI=1S/C45H51N13O9S/c46-41-40(43(61)50-31-6-4-15-47-27-31)51-36(28-49-41)30-9-11-33(12-10-30)68(64,65)57-20-18-55(19-21-57)17-2-1-5-32-29-56(54-53-32)22-24-67-26-25-66-23-16-48-35-8-3-7-34-39(35)45(63)58(44(34)62)37-13-14-38(59)52-42(37)60/h3-4,6-12,15,27-29,37,48H,1-2,5,13-14,16-26H2,(H2,46,49)(H,50,61)(H,52,59,60)","POEDIMKQYSDVSE-UHFFFAOYSA-N"
"2758","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","38.2/88.3","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","950.052","949.365341212","1.25","68","8","18","4","21","279.16","C45H51N13O9S","InChI=1S/C45H51N13O9S/c46-41-40(43(61)50-31-6-4-15-47-27-31)51-36(28-49-41)30-9-11-33(12-10-30)68(64,65)57-20-18-55(19-21-57)17-2-1-5-32-29-56(54-53-32)22-24-67-26-25-66-23-16-48-35-8-3-7-34-39(35)45(63)58(44(34)62)37-13-14-38(59)52-42(37)60/h3-4,6-12,15,27-29,37,48H,1-2,5,13-14,16-26H2,(H2,46,49)(H,50,61)(H,52,59,60)","POEDIMKQYSDVSE-UHFFFAOYSA-N"
"2759","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","69.3/93.8","% GSK3A degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","994.105","993.39155596","1.1","71","8","19","4","24","288.39","C47H55N13O10S","InChI=1S/C47H55N13O10S/c48-43-42(45(63)52-33-6-4-15-49-29-33)53-38(30-51-43)32-9-11-35(12-10-32)71(66,67)59-20-18-57(19-21-59)17-2-1-5-34-31-58(56-55-34)22-24-69-26-28-70-27-25-68-23-16-50-37-8-3-7-36-41(37)47(65)60(46(36)64)39-13-14-40(61)54-44(39)62/h3-4,6-12,15,29-31,39,50H,1-2,5,13-14,16-28H2,(H2,48,51)(H,52,63)(H,54,61,62)","LFQJJPPCBLKJNQ-UHFFFAOYSA-N"
"2759","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","","","","54.6/89.7","% GSK3B degradation in SH-SY5Y cells after 24 h treatment at 1000/10000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","994.105","993.39155596","1.1","71","8","19","4","24","288.39","C47H55N13O10S","InChI=1S/C47H55N13O10S/c48-43-42(45(63)52-33-6-4-15-49-29-33)53-38(30-51-43)32-9-11-35(12-10-32)71(66,67)59-20-18-57(19-21-59)17-2-1-5-34-31-58(56-55-34)22-24-69-26-28-70-27-25-68-23-16-50-37-8-3-7-36-41(37)47(65)60(46(36)64)39-13-14-40(61)54-44(39)62/h3-4,6-12,15,29-31,39,50H,1-2,5,13-14,16-28H2,(H2,48,51)(H,52,63)(H,54,61,62)","LFQJJPPCBLKJNQ-UHFFFAOYSA-N"
"2760","P49841","GSK-3beta","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","110.1","","Degradation of GSK3B in SH-SY5Y cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1038.158","1037.41777071","0.96","74","8","20","4","27","297.62","C49H59N13O11S","InChI=1S/C49H59N13O11S/c50-45-44(47(65)54-35-6-4-15-51-31-35)55-40(32-53-45)34-9-11-37(12-10-34)74(68,69)61-20-18-59(19-21-61)17-2-1-5-36-33-60(58-57-36)22-24-71-26-28-73-30-29-72-27-25-70-23-16-52-39-8-3-7-38-43(39)49(67)62(48(38)66)41-13-14-42(63)56-46(41)64/h3-4,6-12,15,31-33,41,52H,1-2,5,13-14,16-30H2,(H2,50,53)(H,54,65)(H,56,63,64)","MMDZUELMJKLTTR-UHFFFAOYSA-N"
"2760","P49840","GSK3A","CRBN","","","NC1=NC=C(C2=CC=C(S(=O)(=O)N3CCN(CCCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)N=N4)CC3)C=C2)N=C1C(=O)NC1=CC=CN=C1","38.2","","Degradation of GSK3A in SH-SY5Y cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1038.158","1037.41777071","0.96","74","8","20","4","27","297.62","C49H59N13O11S","InChI=1S/C49H59N13O11S/c50-45-44(47(65)54-35-6-4-15-51-31-35)55-40(32-53-45)34-9-11-37(12-10-34)74(68,69)61-20-18-59(19-21-61)17-2-1-5-36-33-60(58-57-36)22-24-71-26-28-73-30-29-72-27-25-70-23-16-52-39-8-3-7-38-43(39)49(67)62(48(38)66)41-13-14-42(63)56-46(41)64/h3-4,6-12,15,31-33,41,52H,1-2,5,13-14,16-30H2,(H2,50,53)(H,54,65)(H,56,63,64)","MMDZUELMJKLTTR-UHFFFAOYSA-N"
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"2769","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","884.685","884.199037512","2.27","56","6","15","3","21","218.34","C37H41IN8O10","InChI=1S/C37H41IN8O10/c1-52-29-9-7-23(20-26(29)38)33-32(41-22-56-33)35(49)40-11-3-4-24-21-45(44-43-24)13-15-54-17-19-55-18-16-53-14-12-39-27-6-2-5-25-31(27)37(51)46(36(25)50)28-8-10-30(47)42-34(28)48/h2,5-7,9,20-22,28,39H,3-4,8,10-19H2,1H3,(H,40,49)(H,42,47,48)","WFMQQECXFYZIEG-UHFFFAOYSA-N"
"2770","P49840","GSK3A","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","928.738","928.22525226","2.13","59","6","16","3","24","227.57","C39H45IN8O11","InChI=1S/C39H45IN8O11/c1-54-31-9-7-25(22-28(31)40)35-34(43-24-59-35)37(51)42-11-3-4-26-23-47(46-45-26)13-15-56-17-19-58-21-20-57-18-16-55-14-12-41-29-6-2-5-27-33(29)39(53)48(38(27)52)30-8-10-32(49)44-36(30)50/h2,5-7,9,22-24,30,41H,3-4,8,10-21H2,1H3,(H,42,51)(H,44,49,50)","XNQYIRKNQMXXKQ-UHFFFAOYSA-N"
"2770","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","928.738","928.22525226","2.13","59","6","16","3","24","227.57","C39H45IN8O11","InChI=1S/C39H45IN8O11/c1-54-31-9-7-25(22-28(31)40)35-34(43-24-59-35)37(51)42-11-3-4-26-23-47(46-45-26)13-15-56-17-19-58-21-20-57-18-16-55-14-12-41-29-6-2-5-27-33(29)39(53)48(38(27)52)30-8-10-32(49)44-36(30)50/h2,5-7,9,22-24,30,41H,3-4,8,10-21H2,1H3,(H,42,51)(H,44,49,50)","XNQYIRKNQMXXKQ-UHFFFAOYSA-N"
"2771","P49840","GSK3A","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","972.791","972.251467008","1.98","62","6","17","3","27","236.8","C41H49IN8O12","InChI=1S/C41H49IN8O12/c1-56-33-9-7-27(24-30(33)42)37-36(45-26-62-37)39(53)44-11-3-4-28-25-49(48-47-28)13-15-58-17-19-60-21-23-61-22-20-59-18-16-57-14-12-43-31-6-2-5-29-35(31)41(55)50(40(29)54)32-8-10-34(51)46-38(32)52/h2,5-7,9,24-26,32,43H,3-4,8,10-23H2,1H3,(H,44,53)(H,46,51,52)","NLDAJHHHSZSUCV-UHFFFAOYSA-N"
"2771","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","972.791","972.251467008","1.98","62","6","17","3","27","236.8","C41H49IN8O12","InChI=1S/C41H49IN8O12/c1-56-33-9-7-27(24-30(33)42)37-36(45-26-62-37)39(53)44-11-3-4-28-25-49(48-47-28)13-15-58-17-19-60-21-23-61-22-20-59-18-16-57-14-12-43-31-6-2-5-29-35(31)41(55)50(40(29)54)32-8-10-34(51)46-38(32)52/h2,5-7,9,24-26,32,43H,3-4,8,10-23H2,1H3,(H,44,53)(H,46,51,52)","NLDAJHHHSZSUCV-UHFFFAOYSA-N"
"2772","P49840","GSK3A","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1016.844","1016.27768176","1.83","65","6","18","3","30","246.03","C43H53IN8O13","InChI=1S/C43H53IN8O13/c1-58-35-9-7-29(26-32(35)44)39-38(47-28-65-39)41(55)46-11-3-4-30-27-51(50-49-30)13-15-60-17-19-62-21-23-64-25-24-63-22-20-61-18-16-59-14-12-45-33-6-2-5-31-37(33)43(57)52(42(31)56)34-8-10-36(53)48-40(34)54/h2,5-7,9,26-28,34,45H,3-4,8,10-25H2,1H3,(H,46,55)(H,48,53,54)","LSXOMQHEBATEPV-UHFFFAOYSA-N"
"2772","P49841","GSK-3beta","CRBN","","","COC1=CC=C(C2=C(C(=O)NCCCC3=CN(CCOCCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)N=CO2)C=C1I","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113889","1016.844","1016.27768176","1.83","65","6","18","3","30","246.03","C43H53IN8O13","InChI=1S/C43H53IN8O13/c1-58-35-9-7-29(26-32(35)44)39-38(47-28-65-39)41(55)46-11-3-4-30-27-51(50-49-30)13-15-60-17-19-62-21-23-64-25-24-63-22-20-61-18-16-59-14-12-45-33-6-2-5-31-37(33)43(57)52(42(31)56)34-8-10-36(53)48-40(34)54/h2,5-7,9,26-28,34,45H,3-4,8,10-25H2,1H3,(H,46,55)(H,48,53,54)","LSXOMQHEBATEPV-UHFFFAOYSA-N"
"2773","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","13","","",">60000","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">60000/>60000","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","623.678","623.271698536","1.09","46","6","12","5","12","202.15","C31H33N11O4","InChI=1S/C31H33N11O4/c32-30-37-31(40-42(30)25-13-11-22(38-39-25)19-6-2-1-3-7-19)35-17-16-34-26(43)10-5-15-33-23-9-4-8-20-21(23)18-41(29(20)46)24-12-14-27(44)36-28(24)45/h1-4,6-9,11,13,24,33H,5,10,12,14-18H2,(H,34,43)(H,36,44,45)(H3,32,35,37,40)","UNNSCNKCWPYRPP-UHFFFAOYSA-N"
"2774","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","14","","","16120.0","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","52250/>60000","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","637.705","637.2873486","1.45","47","6","12","5","13","202.15","C32H35N11O4","InChI=1S/C32H35N11O4/c33-31-38-32(41-43(31)26-14-12-23(39-40-26)20-7-2-1-3-8-20)36-18-17-35-27(44)11-4-5-16-34-24-10-6-9-21-22(24)19-42(30(21)47)25-13-15-28(45)37-29(25)46/h1-3,6-10,12,14,25,34H,4-5,11,13,15-19H2,(H,35,44)(H,37,45,46)(H3,33,36,38,41)","FPYQGBMERPFABP-UHFFFAOYSA-N"
"2775","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","15","","","16220.0","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31720/27850","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","651.732","651.302998664","1.81","48","6","12","5","14","202.15","C33H37N11O4","InChI=1S/C33H37N11O4/c34-32-39-33(42-44(32)27-15-13-24(40-41-27)21-8-3-1-4-9-21)37-19-18-36-28(45)12-5-2-6-17-35-25-11-7-10-22-23(25)20-43(31(22)48)26-14-16-29(46)38-30(26)47/h1,3-4,7-11,13,15,26,35H,2,5-6,12,14,16-20H2,(H,36,45)(H,38,46,47)(H3,34,37,39,42)","XPUQCHODVKLTMP-UHFFFAOYSA-N"
"2776","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","16","","",">60000","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">60000/>60000","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","665.759","665.318648728","2.35","49","6","12","5","15","202.15","C34H39N11O4","InChI=1S/C34H39N11O4/c35-33-40-34(43-45(33)28-16-14-25(41-42-28)22-9-4-3-5-10-22)38-20-19-37-29(46)13-6-1-2-7-18-36-26-12-8-11-23-24(26)21-44(32(23)49)27-15-17-30(47)39-31(27)48/h3-5,8-12,14,16,27,36H,1-2,6-7,13,15,17-21H2,(H,37,46)(H,39,47,48)(H3,35,38,40,43)","KZRVCCYBWNLWLP-UHFFFAOYSA-N"
"2777","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","17","","","8520","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","34740/19480","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","679.786","679.334298792","2.89","50","6","12","5","16","202.15","C35H41N11O4","InChI=1S/C35H41N11O4/c36-34-41-35(44-46(34)29-17-15-26(42-43-29)23-10-5-4-6-11-23)39-21-20-38-30(47)14-7-2-1-3-8-19-37-27-13-9-12-24-25(27)22-45(33(24)50)28-16-18-31(48)40-32(28)49/h4-6,9-13,15,17,28,37H,1-3,7-8,14,16,18-22H2,(H,38,47)(H,40,48,49)(H3,36,39,41,44)","FZUHYNOPZMOKBL-UHFFFAOYSA-N"
"2778","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","18","","","7230","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","47990/>60000","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","685.749","685.2873486","2.45","51","7","12","5","12","202.15","C36H35N11O4","InChI=1S/C36H35N11O4/c37-35-42-36(45-47(35)30-17-15-27(43-44-30)23-6-2-1-3-7-23)40-24-13-11-22(12-14-24)20-39-31(48)10-5-19-38-28-9-4-8-25-26(28)21-46(34(25)51)29-16-18-32(49)41-33(29)50/h1-4,6-9,11-15,17,29,38H,5,10,16,18-21H2,(H,39,48)(H,41,49,50)(H3,37,40,42,45)","HHLKXRVRLAEGAS-UHFFFAOYSA-N"
"2779","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","19","","","1730","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","35730/54210","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","699.776","699.302998664","2.81","52","7","12","5","13","202.15","C37H37N11O4","InChI=1S/C37H37N11O4/c38-36-43-37(46-48(36)31-18-16-28(44-45-31)24-7-2-1-3-8-24)41-25-14-12-23(13-15-25)21-40-32(49)11-4-5-20-39-29-10-6-9-26-27(29)22-47(35(26)52)30-17-19-33(50)42-34(30)51/h1-3,6-10,12-16,18,30,39H,4-5,11,17,19-22H2,(H,40,49)(H,42,50,51)(H3,38,41,43,46)","OYAFTFKNDYWZEF-UHFFFAOYSA-N"
"2780","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","20","","","1610","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6230/2060","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","713.803","713.318648728","3.16","53","7","12","5","14","202.15","C38H39N11O4","InChI=1S/C38H39N11O4/c39-37-44-38(47-49(37)32-19-17-29(45-46-32)25-8-3-1-4-9-25)42-26-15-13-24(14-16-26)22-41-33(50)12-5-2-6-21-40-30-11-7-10-27-28(30)23-48(36(27)53)31-18-20-34(51)43-35(31)52/h1,3-4,7-11,13-17,19,31,40H,2,5-6,12,18,20-23H2,(H,41,50)(H,43,51,52)(H3,39,42,44,47)","OXOOPNYJFVRNCT-UHFFFAOYSA-N"
"2781","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","21","","","5340","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","28530/24620","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","727.83","727.334298792","3.71","54","7","12","5","15","202.15","C39H41N11O4","InChI=1S/C39H41N11O4/c40-38-45-39(48-50(38)33-20-18-30(46-47-33)26-9-4-3-5-10-26)43-27-16-14-25(15-17-27)23-42-34(51)13-6-1-2-7-22-41-31-12-8-11-28-29(31)24-49(37(28)54)32-19-21-35(52)44-36(32)53/h3-5,8-12,14-18,20,32,41H,1-2,6-7,13,19,21-24H2,(H,42,51)(H,44,52,53)(H3,40,43,45,48)","GNAWWNHIIPKTCJ-UHFFFAOYSA-N"
"2782","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC=C(C2=CC=CC=C2)N=N1","","","22","","","920","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10340/5530","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","741.857","741.349948856","4.25","55","7","12","5","16","202.15","C40H43N11O4","InChI=1S/C40H43N11O4/c41-39-46-40(49-51(39)34-21-19-31(47-48-34)27-10-5-4-6-11-27)44-28-17-15-26(16-18-28)24-43-35(52)14-7-2-1-3-8-23-42-32-13-9-12-29-30(32)25-50(38(29)55)33-20-22-36(53)45-37(33)54/h4-6,9-13,15-19,21,33,42H,1-3,7-8,14,20,22-25H2,(H,43,52)(H,45,53,54)(H3,41,44,46,49)","MJLYJIABKSUTCI-UHFFFAOYSA-N"
"2783","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","23","","",">60000","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">60000/39220","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","663.743","663.302998664","1.93","49","7","12","5","11","202.15","C34H37N11O4","InChI=1S/C34H37N11O4/c35-33-40-34(43-45(33)27-18-21-8-3-7-20-6-1-2-9-22(20)30(21)42-41-27)38-17-16-37-28(46)12-5-15-36-25-11-4-10-23-24(25)19-44(32(23)49)26-13-14-29(47)39-31(26)48/h1-2,4,6,9-11,18,26,36H,3,5,7-8,12-17,19H2,(H,37,46)(H,39,47,48)(H3,35,38,40,43)","NXHIDNSKPOCCDZ-UHFFFAOYSA-N"
"2784","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","24","","","3620","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","36250/7050","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","677.77","677.318648728","2.29","50","7","12","5","12","202.15","C35H39N11O4","InChI=1S/C35H39N11O4/c36-34-41-35(44-46(34)28-19-22-9-5-8-21-7-1-2-10-23(21)31(22)43-42-28)39-18-17-38-29(47)13-3-4-16-37-26-12-6-11-24-25(26)20-45(33(24)50)27-14-15-30(48)40-32(27)49/h1-2,6-7,10-12,19,27,37H,3-5,8-9,13-18,20H2,(H,38,47)(H,40,48,49)(H3,36,39,41,44)","ANKROASJOOUVQF-UHFFFAOYSA-N"
"2785","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","25","","","2100","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">60000/37460","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","691.797","691.334298792","2.64","51","7","12","5","13","202.15","C36H41N11O4","InChI=1S/C36H41N11O4/c37-35-42-36(45-47(35)29-20-23-10-6-9-22-8-3-4-11-24(22)32(23)44-43-29)40-19-18-39-30(48)14-2-1-5-17-38-27-13-7-12-25-26(27)21-46(34(25)51)28-15-16-31(49)41-33(28)50/h3-4,7-8,11-13,20,28,38H,1-2,5-6,9-10,14-19,21H2,(H,39,48)(H,41,49,50)(H3,37,40,42,45)","SXYIHFOWRMFUGU-UHFFFAOYSA-N"
"2786","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","26","","","4160","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","44560/41290","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","705.824","705.349948856","3.19","52","7","12","5","14","202.15","C37H43N11O4","InChI=1S/C37H43N11O4/c38-36-43-37(46-48(36)30-21-24-11-7-10-23-9-4-5-12-25(23)33(24)45-44-30)41-20-19-40-31(49)15-3-1-2-6-18-39-28-14-8-13-26-27(28)22-47(35(26)52)29-16-17-32(50)42-34(29)51/h4-5,8-9,12-14,21,29,39H,1-3,6-7,10-11,15-20,22H2,(H,40,49)(H,42,50,51)(H3,38,41,43,46)","GJBFAPHCTKZDFI-UHFFFAOYSA-N"
"2787","P30530","AXL","CRBN","","","NC1=NC(NCCNC(=O)CCCCCCCNC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","27","","","9210","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">60000/27150","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","719.851","719.36559892","3.73","53","7","12","5","15","202.15","C38H45N11O4","InChI=1S/C38H45N11O4/c39-37-44-38(47-49(37)31-22-25-12-8-11-24-10-5-6-13-26(24)34(25)46-45-31)42-21-20-41-32(50)16-4-2-1-3-7-19-40-29-15-9-14-27-28(29)23-48(36(27)53)30-17-18-33(51)43-35(30)52/h5-6,9-10,13-15,22,30,40H,1-4,7-8,11-12,16-21,23H2,(H,41,50)(H,43,51,52)(H3,39,42,44,47)","HFCCDMNTBZKLBL-UHFFFAOYSA-N"
"2788","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","28","","","2460","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","41260/34560","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","725.814","725.318648728","3.29","54","8","12","5","11","202.15","C39H39N11O4","InChI=1S/C39H39N11O4/c40-38-45-39(48-50(38)32-20-25-8-3-7-24-6-1-2-9-27(24)35(25)47-46-32)43-26-15-13-23(14-16-26)21-42-33(51)12-5-19-41-30-11-4-10-28-29(30)22-49(37(28)54)31-17-18-34(52)44-36(31)53/h1-2,4,6,9-11,13-16,20,31,41H,3,5,7-8,12,17-19,21-22H2,(H,42,51)(H,44,52,53)(H3,40,43,45,48)","LRBWOQPOKMXZHT-UHFFFAOYSA-N"
"2789","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","29","","","2280","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39120/41260","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","739.841","739.334298792","3.64","55","8","12","5","12","202.15","C40H41N11O4","InChI=1S/C40H41N11O4/c41-39-46-40(49-51(39)33-21-26-9-5-8-25-7-1-2-10-28(25)36(26)48-47-33)44-27-16-14-24(15-17-27)22-43-34(52)13-3-4-20-42-31-12-6-11-29-30(31)23-50(38(29)55)32-18-19-35(53)45-37(32)54/h1-2,6-7,10-12,14-17,21,32,42H,3-5,8-9,13,18-20,22-23H2,(H,43,52)(H,45,53,54)(H3,41,44,46,49)","FCNBVZZIMBCVKW-UHFFFAOYSA-N"
"2790","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","30","","","6360","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32770/29610","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","753.868","753.349948856","4.0","56","8","12","5","13","202.15","C41H43N11O4","InChI=1S/C41H43N11O4/c42-40-47-41(50-52(40)34-22-27-10-6-9-26-8-3-4-11-29(26)37(27)49-48-34)45-28-17-15-25(16-18-28)23-44-35(53)14-2-1-5-21-43-32-13-7-12-30-31(32)24-51(39(30)56)33-19-20-36(54)46-38(33)55/h3-4,7-8,11-13,15-18,22,33,43H,1-2,5-6,9-10,14,19-21,23-24H2,(H,44,53)(H,46,54,55)(H3,42,45,47,50)","XDHWSJMSRBGBMJ-UHFFFAOYSA-N"
"2791","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","31","","","3760","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","29540/22340","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","767.895","767.36559892","4.54","57","8","12","5","14","202.15","C42H45N11O4","InChI=1S/C42H45N11O4/c43-41-48-42(51-53(41)35-23-28-11-7-10-27-9-4-5-12-30(27)38(28)50-49-35)46-29-18-16-26(17-19-29)24-45-36(54)15-3-1-2-6-22-44-33-14-8-13-31-32(33)25-52(40(31)57)34-20-21-37(55)47-39(34)56/h4-5,8-9,12-14,16-19,23,34,44H,1-3,6-7,10-11,15,20-22,24-25H2,(H,45,54)(H,47,55,56)(H3,43,46,48,51)","LDICVMYLJQLXHY-UHFFFAOYSA-N"
"2792","P30530","AXL","CRBN","","","NC1=NC(NC2=CC=C(CNC(=O)CCCCCCCNC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C=C2)=NN1C1=CC2=C(N=N1)C1=CC=CC=C1CCC2","","","32","","","2380","IC50 was assessed by the HTRF assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27620/21080","Inhibit proliferation of MDA-MB-231/4T1 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2022.114253","781.922","781.381248984","5.08","58","8","12","5","15","202.15","C43H47N11O4","InChI=1S/C43H47N11O4/c44-42-49-43(52-54(42)36-24-29-12-8-11-28-10-5-6-13-31(28)39(29)51-50-36)47-30-19-17-27(18-20-30)25-46-37(55)16-4-2-1-3-7-23-45-34-15-9-14-32-33(34)26-53(41(32)58)35-21-22-38(56)48-40(35)57/h5-6,9-10,13-15,17-20,24,35,45H,1-4,7-8,11-12,16,21-23,25-26H2,(H,46,55)(H,48,56,57)(H3,44,47,49,52)","PYKQMJVKOVFBPH-UHFFFAOYSA-N"
"2793","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=CC=C2)C(=O)CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","56","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","764.279","763.277276364","5.09","55","6","7","3","10","157.98","C42H42ClN5O7","InChI=1S/C42H42ClN5O7/c1-5-55-41(54)36-35(29-19-18-27(43)22-31(29)44-36)37(39(52)46-42(2,3)4)48(23-25-12-7-6-8-13-25)34(50)17-10-9-14-26-15-11-16-28-30(26)24-47(40(28)53)32-20-21-33(49)45-38(32)51/h6-8,11-13,15-16,18-19,22,32,37,44H,5,10,17,20-21,23-24H2,1-4H3,(H,46,52)(H,45,49,51)","SOMTYCCNAWJGOR-UHFFFAOYSA-N"
"2794","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=CC=C2)C(=O)CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.6","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","778.306","777.292926428","5.45","56","6","7","3","11","157.98","C43H44ClN5O7","InChI=1S/C43H44ClN5O7/c1-5-56-42(55)37-36(30-20-19-28(44)23-32(30)45-37)38(40(53)47-43(2,3)4)49(24-26-13-8-6-9-14-26)35(51)18-11-7-10-15-27-16-12-17-29-31(27)25-48(41(29)54)33-21-22-34(50)46-39(33)52/h6,8-9,12-14,16-17,19-20,23,33,38,45H,5,7,11,18,21-22,24-25H2,1-4H3,(H,47,53)(H,46,50,52)","JFQFZSQXJWINQP-UHFFFAOYSA-N"
"2795","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=CC=C2)C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.8","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","792.333","791.308576492","5.99","57","6","7","3","12","157.98","C44H46ClN5O7","InChI=1S/C44H46ClN5O7/c1-5-57-43(56)38-37(31-21-20-29(45)24-33(31)46-38)39(41(54)48-44(2,3)4)50(25-27-14-9-8-10-15-27)36(52)19-12-7-6-11-16-28-17-13-18-30-32(28)26-49(42(30)55)34-22-23-35(51)47-40(34)53/h8-10,13-15,17-18,20-21,24,34,39,46H,5-7,12,19,22-23,25-26H2,1-4H3,(H,48,54)(H,47,51,53)","HZTDAEDJGYAXMR-UHFFFAOYSA-N"
"2796","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=C(Cl)C=C2)C(=O)CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1403","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","798.724","797.238304012","5.72","56","6","7","3","10","157.98","C42H41Cl2N5O7","InChI=1S/C42H41Cl2N5O7/c1-5-56-41(55)36-35(29-18-17-27(44)21-31(29)45-36)37(39(53)47-42(2,3)4)49(22-24-13-15-26(43)16-14-24)34(51)12-7-6-9-25-10-8-11-28-30(25)23-48(40(28)54)32-19-20-33(50)46-38(32)52/h8,10-11,13-18,21,32,37,45H,5,7,12,19-20,22-23H2,1-4H3,(H,47,53)(H,46,50,52)","QAKKCPDYLWZXON-UHFFFAOYSA-N"
"2797","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=C(Cl)C=C2)C(=O)CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5.3","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","812.751","811.253954076","6.08","57","6","7","3","11","157.98","C43H43Cl2N5O7","InChI=1S/C43H43Cl2N5O7/c1-5-57-42(56)37-36(30-19-18-28(45)22-32(30)46-37)38(40(54)48-43(2,3)4)50(23-25-14-16-27(44)17-15-25)35(52)13-8-6-7-10-26-11-9-12-29-31(26)24-49(41(29)55)33-20-21-34(51)47-39(33)53/h9,11-12,14-19,22,33,38,46H,5-6,8,13,20-21,23-24H2,1-4H3,(H,48,54)(H,47,51,53)","MCEPFWTVYSPNQF-UHFFFAOYSA-N"
"2798","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC=C(Cl)C=C2)C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.3","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","826.778","825.26960414","6.62","58","6","7","3","12","157.98","C44H45Cl2N5O7","InChI=1S/C44H45Cl2N5O7/c1-5-58-43(57)38-37(31-20-19-29(46)23-33(31)47-38)39(41(55)49-44(2,3)4)51(24-26-15-17-28(45)18-16-26)36(53)14-9-7-6-8-11-27-12-10-13-30-32(27)25-50(42(30)56)34-21-22-35(52)48-40(34)54/h10,12-13,15-20,23,34,39,47H,5-7,9,14,21-22,24-25H2,1-4H3,(H,49,55)(H,48,52,54)","XDAGBGVNXQDSFS-UHFFFAOYSA-N"
"2799","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","95.9","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","818.249","817.249010928","5.39","58","6","7","3","10","157.98","C42H39ClF3N5O7","InChI=1S/C42H39ClF3N5O7/c1-5-58-41(57)36-34(26-14-13-24(43)19-30(26)47-36)37(39(55)49-42(2,3)4)51(20-22-17-28(44)35(46)29(45)18-22)33(53)12-7-6-9-23-10-8-11-25-27(23)21-50(40(25)56)31-15-16-32(52)48-38(31)54/h8,10-11,13-14,17-19,31,37,47H,5,7,12,15-16,20-21H2,1-4H3,(H,49,55)(H,48,52,54)","XIOIUMROBDJBEN-UHFFFAOYSA-N"
"2800","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.2","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","832.276","831.264660992","5.75","59","6","7","3","11","157.98","C43H41ClF3N5O7","InChI=1S/C43H41ClF3N5O7/c1-5-59-42(58)37-35(27-15-14-25(44)20-31(27)48-37)38(40(56)50-43(2,3)4)52(21-23-18-29(45)36(47)30(46)19-23)34(54)13-8-6-7-10-24-11-9-12-26-28(24)22-51(41(26)57)32-16-17-33(53)49-39(32)55/h9,11-12,14-15,18-20,32,38,48H,5-6,8,13,16-17,21-22H2,1-4H3,(H,50,56)(H,49,53,55)","WWXPWUMFQYKOPY-UHFFFAOYSA-N"
"2801","Q00987","MDM2","CRBN","","WB214","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","4.1","","Degradation of MDM2 in RS4;11 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.2","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","846.303","845.280311056","6.29","60","6","7","3","12","157.98","C44H43ClF3N5O7","InChI=1S/C44H43ClF3N5O7/c1-5-60-43(59)38-36(28-16-15-26(45)21-32(28)49-38)39(41(57)51-44(2,3)4)53(22-24-19-30(46)37(48)31(47)20-24)35(55)14-9-7-6-8-11-25-12-10-13-27-29(25)23-52(42(27)58)33-17-18-34(54)50-40(33)56/h10,12-13,15-16,19-21,33,39,49H,5-7,9,14,17-18,22-23H2,1-4H3,(H,51,57)(H,50,54,56)","WGGGBWUFPMJXRU-UHFFFAOYSA-N"
"2802","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.76","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","860.33","859.29596112","6.83","61","6","7","3","13","157.98","C45H45ClF3N5O7","InChI=1S/C45H45ClF3N5O7/c1-5-61-44(60)39-37(29-17-16-27(46)22-33(29)50-39)40(42(58)52-45(2,3)4)54(23-25-20-31(47)38(49)32(48)21-25)36(56)15-10-8-6-7-9-12-26-13-11-14-28-30(26)24-53(43(28)59)34-18-19-35(55)51-41(34)57/h11,13-14,16-17,20-22,34,40,50H,5-8,10,15,18-19,23-24H2,1-4H3,(H,52,58)(H,51,55,57)","PWKVSHYUQVVESP-UHFFFAOYSA-N"
"2803","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.6","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","874.357","873.311611184","7.38","62","6","7","3","14","157.98","C46H47ClF3N5O7","InChI=1S/C46H47ClF3N5O7/c1-5-62-45(61)40-38(30-18-17-28(47)23-34(30)51-40)41(43(59)53-46(2,3)4)55(24-26-21-32(48)39(50)33(49)22-26)37(57)16-11-9-7-6-8-10-13-27-14-12-15-29-31(27)25-54(44(29)60)35-19-20-36(56)52-42(35)58/h12,14-15,17-18,21-23,35,41,51H,5-9,11,16,19-20,24-25H2,1-4H3,(H,53,59)(H,52,56,58)","MFUGREJDISQKLY-UHFFFAOYSA-N"
"2804","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","888.384","887.327261248","7.92","63","6","7","3","15","157.98","C47H49ClF3N5O7","InChI=1S/C47H49ClF3N5O7/c1-5-63-46(62)41-39(31-19-18-29(48)24-35(31)52-41)42(44(60)54-47(2,3)4)56(25-27-22-33(49)40(51)34(50)23-27)38(58)17-12-10-8-6-7-9-11-14-28-15-13-16-30-32(28)26-55(45(30)61)36-20-21-37(57)53-43(36)59/h13,15-16,18-19,22-24,36,42,52H,5-10,12,17,20-21,25-26H2,1-4H3,(H,54,60)(H,53,57,59)","NODNBVRPBMZPSV-UHFFFAOYSA-N"
"2805","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCCCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","250","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","902.411","901.342911312","8.46","64","6","7","3","16","157.98","C48H51ClF3N5O7","InChI=1S/C48H51ClF3N5O7/c1-5-64-47(63)42-40(32-20-19-30(49)25-36(32)53-42)43(45(61)55-48(2,3)4)57(26-28-23-34(50)41(52)35(51)24-28)39(59)18-13-11-9-7-6-8-10-12-15-29-16-14-17-31-33(29)27-56(46(31)62)37-21-22-38(58)54-44(37)60/h14,16-17,19-20,23-25,37,43,53H,5-11,13,18,21-22,26-27H2,1-4H3,(H,55,61)(H,54,58,60)","LUISQUONUBEFKH-UHFFFAOYSA-N"
"2806","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1=C(C(=O)O)[NH]C2=CC(Cl)=CC=C12)N(CC1=CC(F)=C(F)C(F)=C1)C(=O)CCCCC#CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","818.249","817.249010928","5.6","58","6","6","4","11","168.98","C42H39ClF3N5O7","InChI=1S/C42H39ClF3N5O7/c1-42(2,3)49-39(55)37(34-26-14-13-24(43)19-30(26)47-36(34)41(57)58)51(20-22-17-28(44)35(46)29(45)18-22)33(53)12-7-5-4-6-9-23-10-8-11-25-27(23)21-50(40(25)56)31-15-16-32(52)48-38(31)54/h8,10-11,13-14,17-19,31,37,47H,4-5,7,12,15-16,20-21H2,1-3H3,(H,49,55)(H,57,58)(H,48,52,54)","RJIYFISVXLOCRG-UHFFFAOYSA-N"
"2807","Q00987","MDM2","CRBN","","","CCNC(=O)C1=C(C(C(=O)NC(C)(C)C)N(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.4","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","845.319","844.296295468","5.72","60","6","6","4","12","160.78","C44H44ClF3N6O6","InChI=1S/C44H44ClF3N6O6/c1-5-49-41(58)38-36(28-16-15-26(45)21-32(28)50-38)39(42(59)52-44(2,3)4)54(22-24-19-30(46)37(48)31(47)20-24)35(56)14-9-7-6-8-11-25-12-10-13-27-29(25)23-53(43(27)60)33-17-18-34(55)51-40(33)57/h10,12-13,15-16,19-21,33,39,50H,5-7,9,14,17-18,22-23H2,1-4H3,(H,49,58)(H,52,59)(H,51,55,57)","SIXNGKNLPNQFCD-UHFFFAOYSA-N"
"2808","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1=C(C(=O)NCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)[NH]C2=CC(Cl)=CC=C12)N(C=O)CC1=CC(F)=C(F)C(F)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","61","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","775.184","774.218045148","4.61","55","6","6","4","9","160.78","C39H34ClF3N6O6","InChI=1S/C39H34ClF3N6O6/c1-39(2,3)47-37(54)34(48(19-50)17-20-14-26(41)32(43)27(42)15-20)31-24-10-9-22(40)16-28(24)45-33(31)36(53)44-13-5-7-21-6-4-8-23-25(21)18-49(38(23)55)29-11-12-30(51)46-35(29)52/h4,6,8-10,14-16,19,29,34,45H,11-13,17-18H2,1-3H3,(H,44,53)(H,47,54)(H,46,51,52)","VKQJFXPRBWRZOT-UHFFFAOYSA-N"
"2809","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1=C(C(=O)NCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)[NH]C2=CC(Cl)=CC=C12)N(C=O)CC1=CC(F)=C(F)C(F)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","789.211","788.233695212","5.08","56","6","6","4","10","160.78","C40H36ClF3N6O6","InChI=1S/C40H36ClF3N6O6/c1-40(2,3)48-38(55)35(49(20-51)18-21-15-27(42)33(44)28(43)16-21)32-25-11-10-23(41)17-29(25)46-34(32)37(54)45-14-5-4-7-22-8-6-9-24-26(22)19-50(39(24)56)30-12-13-31(52)47-36(30)53/h6,8-11,15-17,20,30,35,46H,5,12-14,18-19H2,1-3H3,(H,45,54)(H,48,55)(H,47,52,53)","TVVMMAARFSBFDB-UHFFFAOYSA-N"
"2810","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1=C(C(=O)NCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)[NH]C2=CC(Cl)=CC=C12)N(C=O)CC1=CC(F)=C(F)C(F)=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","446","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","803.238","802.249345276","5.43","57","6","6","4","11","160.78","C41H38ClF3N6O6","InChI=1S/C41H38ClF3N6O6/c1-41(2,3)49-39(56)36(50(21-52)19-22-16-28(43)34(45)29(44)17-22)33-26-12-11-24(42)18-30(26)47-35(33)38(55)46-15-6-4-5-8-23-9-7-10-25-27(23)20-51(40(25)57)31-13-14-32(53)48-37(31)54/h7,9-12,16-18,21,31,36,47H,4,6,13-15,19-20H2,1-3H3,(H,46,55)(H,49,56)(H,48,53,54)","RFXURGHBZITSPV-UHFFFAOYSA-N"
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"2823","Q00987","MDM2","CRBN","","","CCN(C(=O)CCCCC#CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)C(C(=O)NC(C)(C)C)C1=CC=C(Cl)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","619.162","618.260898028","4.18","44","4","5","2","9","115.89","C34H39ClN4O5","InChI=1S/C34H39ClN4O5/c1-5-38(30(32(43)37-34(2,3)4)23-15-17-24(35)18-16-23)29(41)14-9-7-6-8-11-22-12-10-13-25-26(22)21-39(33(25)44)27-19-20-28(40)36-31(27)42/h10,12-13,15-18,27,30H,5-7,9,14,19-21H2,1-4H3,(H,37,43)(H,36,40,42)","ICNQJWBMKKSVTJ-UHFFFAOYSA-N"
"2824","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1=CC=C(Cl)C=C1)N(CC1=CC(F)=C(F)C(F)=C1)C(=O)CCCCC#CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","735.203","734.248282656","5.61","52","5","5","2","10","115.89","C39H38ClF3N4O5","InChI=1S/C39H38ClF3N4O5/c1-39(2,3)45-37(51)35(25-13-15-26(40)16-14-25)47(21-23-19-29(41)34(43)30(42)20-23)33(49)12-7-5-4-6-9-24-10-8-11-27-28(24)22-46(38(27)52)31-17-18-32(48)44-36(31)50/h8,10-11,13-16,19-20,31,35H,4-5,7,12,17-18,21-22H2,1-3H3,(H,45,51)(H,44,48,50)","PHAONSFSWSPKAF-UHFFFAOYSA-N"
"2825","Q00987","MDM2","CRBN","","","CC(C)C(C(=O)NC(C)(C)C)N(CC1=CC(F)=C(F)C(F)=C1)C(=O)CCCCC#CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","666.741","666.302905072","4.65","48","4","5","2","10","115.89","C36H41F3N4O5","InChI=1S/C36H41F3N4O5/c1-21(2)32(34(47)41-36(3,4)5)43(19-22-17-26(37)31(39)27(38)18-22)30(45)14-9-7-6-8-11-23-12-10-13-24-25(23)20-42(35(24)48)28-15-16-29(44)40-33(28)46/h10,12-13,17-18,21,28,32H,6-7,9,14-16,19-20H2,1-5H3,(H,41,47)(H,40,44,46)","UNJPBMRJJKNSLP-UHFFFAOYSA-N"
"2826","Q00987","MDM2","CRBN","","","CC(C)(C)NC(=O)C(C1CCCCC1)N(CC1=CC(F)=C(F)C(F)=C1)C(=O)CCCCC#CC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1240","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","706.806","706.3342052","5.69","51","5","5","2","10","115.89","C39H45F3N4O5","InChI=1S/C39H45F3N4O5/c1-39(2,3)44-37(50)35(26-13-8-6-9-14-26)46(22-24-20-29(40)34(42)30(41)21-24)33(48)17-10-5-4-7-12-25-15-11-16-27-28(25)23-45(38(27)51)31-18-19-32(47)43-36(31)49/h11,15-16,20-21,26,31,35H,4-6,8-10,13-14,17-19,22-23H2,1-3H3,(H,44,50)(H,43,47,49)","SRTZHKMVLVXXAG-UHFFFAOYSA-N"
"2827","Q00987","MDM2","CRBN","","","CCOC(=O)C1=C(CN(CC2=CC(F)=C(F)C(F)=C2)C(=O)CCCCC#CC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C2=CC=C(Cl)C=C2[NH]1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16.9","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","747.17","746.211897148","5.76","53","6","6","2","11","128.88","C39H34ClF3N4O6","InChI=1S/C39H34ClF3N4O6/c1-2-53-39(52)36-28(25-13-12-24(40)18-31(25)44-36)20-46(19-22-16-29(41)35(43)30(42)17-22)34(49)11-6-4-3-5-8-23-9-7-10-26-27(23)21-47(38(26)51)32-14-15-33(48)45-37(32)50/h7,9-10,12-13,16-18,32,44H,2-4,6,11,14-15,19-21H2,1H3,(H,45,48,50)","CQFIHGSLMIVZFY-UHFFFAOYSA-N"
"2828","Q00987","MDM2","CRBN","","","O=C1CCC(N2CC3=C(C#CCCCCC(=O)N(CC4=CC=C(Cl)C=C4)CC4=CC(F)=C(F)C(F)=C4)C=CC=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19.7","Inhibit growth of RS4;11 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113425","636.07","635.179868748","5.08","45","5","4","1","9","86.79","C34H29ClF3N3O4","InChI=1S/C34H29ClF3N3O4/c35-24-12-10-21(11-13-24)18-40(19-22-16-27(36)32(38)28(37)17-22)31(43)9-4-2-1-3-6-23-7-5-8-25-26(23)20-41(34(25)45)29-14-15-30(42)39-33(29)44/h5,7-8,10-13,16-17,29H,1-2,4,9,14-15,18-20H2,(H,39,42,44)","IKVRLUSCVWHORQ-UHFFFAOYSA-N"
"2829","P01116","KRAS G12C","VHL","","YF135","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCCN3CCC[C@H]3COC3=NC4=C(CCN(C5=CC=CC6=CC=CC(Cl)=C56)C4)C(N4CCN(C(=O)/C(C#N)=C\C5CC5)[C@@H](CC#N)C4)=N3)C(C)(C)C)C=C2)SC=N1","3610/4530","","Degradation of KRAS G12C in H358/H23 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","153.9/243.9","Inhibit proliferation of H358/H23 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.114088","1179.89","1178.52909142","7.67","84","10","16","3","21","233.48","C63H75ClN12O7S","InChI=1S/C63H75ClN12O7S/c1-40-56(84-39-68-40)44-18-16-42(17-19-44)34-67-59(79)53-32-48(77)36-76(53)61(81)57(63(2,3)4)70-54(78)22-30-82-29-8-25-72-24-7-11-47(72)38-83-62-69-51-37-73(52-13-6-10-43-9-5-12-50(64)55(43)52)26-21-49(51)58(71-62)74-27-28-75(46(35-74)20-23-65)60(80)45(33-66)31-41-14-15-41/h5-6,9-10,12-13,16-19,31,39,41,46-48,53,57,77H,7-8,11,14-15,20-22,24-30,32,34-38H2,1-4H3,(H,67,79)(H,70,78)/b45-31-/t46-,47-,48+,53-,57+/m0/s1","VJEBOMJUVXOGQI-OAHWIDGASA-N"
"2830","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","721.13","720.184772948","4.26","52","7","11","5","12","204.58","C36H29ClN8O7","InChI=1S/C36H29ClN8O7/c37-24-15-20(52-19-5-2-1-3-6-19)9-10-21(24)31(48)23-16-40-32-30(23)33(43-18-42-32)41-17-28(47)39-14-13-38-25-8-4-7-22-29(25)36(51)45(35(22)50)26-11-12-27(46)44-34(26)49/h1-10,15-16,18,26,38H,11-14,17H2,(H,39,47)(H,44,46,49)(H2,40,41,42,43)","YPOJRIPORCPJLW-UHFFFAOYSA-N"
"2830","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","721.13","720.184772948","4.26","52","7","11","5","12","204.58","C36H29ClN8O7","InChI=1S/C36H29ClN8O7/c37-24-15-20(52-19-5-2-1-3-6-19)9-10-21(24)31(48)23-16-40-32-30(23)33(43-18-42-32)41-17-28(47)39-14-13-38-25-8-4-7-22-29(25)36(51)45(35(22)50)26-11-12-27(46)44-34(26)49/h1-10,15-16,18,26,38H,11-14,17H2,(H,39,47)(H,44,46,49)(H2,40,41,42,43)","YPOJRIPORCPJLW-UHFFFAOYSA-N"
"2831","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","749.184","748.216073076","4.97","54","7","11","5","14","204.58","C38H33ClN8O7","InChI=1S/C38H33ClN8O7/c39-26-17-22(54-21-7-2-1-3-8-21)11-12-23(26)33(50)25-18-42-34-32(25)35(45-20-44-34)43-19-30(49)41-16-5-4-15-40-27-10-6-9-24-31(27)38(53)47(37(24)52)28-13-14-29(48)46-36(28)51/h1-3,6-12,17-18,20,28,40H,4-5,13-16,19H2,(H,41,49)(H,46,48,51)(H2,42,43,44,45)","GCSPFUMHFNOLJR-UHFFFAOYSA-N"
"2831","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","749.184","748.216073076","4.97","54","7","11","5","14","204.58","C38H33ClN8O7","InChI=1S/C38H33ClN8O7/c39-26-17-22(54-21-7-2-1-3-8-21)11-12-23(26)33(50)25-18-42-34-32(25)35(45-20-44-34)43-19-30(49)41-16-5-4-15-40-27-10-6-9-24-31(27)38(53)47(37(24)52)28-13-14-29(48)46-36(28)51/h1-3,6-12,17-18,20,28,40H,4-5,13-16,19H2,(H,41,49)(H,46,48,51)(H2,42,43,44,45)","GCSPFUMHFNOLJR-UHFFFAOYSA-N"
"2832","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","3775","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","809.236","808.237202444","3.96","58","7","13","5","18","223.04","C40H37ClN8O9","InChI=1S/C40H37ClN8O9/c41-28-19-24(58-23-5-2-1-3-6-23)9-10-25(28)35(52)27-20-44-36-34(27)37(47-22-46-36)45-21-32(51)43-14-16-57-18-17-56-15-13-42-29-8-4-7-26-33(29)40(55)49(39(26)54)30-11-12-31(50)48-38(30)53/h1-10,19-20,22,30,42H,11-18,21H2,(H,43,51)(H,48,50,53)(H2,44,45,46,47)","LNGVZKNBHLZMMG-UHFFFAOYSA-N"
"2832","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","809.236","808.237202444","3.96","58","7","13","5","18","223.04","C40H37ClN8O9","InChI=1S/C40H37ClN8O9/c41-28-19-24(58-23-5-2-1-3-6-23)9-10-25(28)35(52)27-20-44-36-34(27)37(47-22-46-36)45-21-32(51)43-14-16-57-18-17-56-15-13-42-29-8-4-7-26-33(29)40(55)49(39(26)54)30-11-12-31(50)48-38(30)53/h1-10,19-20,22,30,42H,11-18,21H2,(H,43,51)(H,48,50,53)(H2,44,45,46,47)","LNGVZKNBHLZMMG-UHFFFAOYSA-N"
"2833","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","28.5","67.1","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","1931.5","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","853.289","852.263417192","3.82","61","7","14","5","21","232.27","C42H41ClN8O10","InChI=1S/C42H41ClN8O10/c43-30-21-26(61-25-5-2-1-3-6-25)9-10-27(30)37(54)29-22-46-38-36(29)39(49-24-48-38)47-23-34(53)45-14-16-59-18-20-60-19-17-58-15-13-44-31-8-4-7-28-35(31)42(57)51(41(28)56)32-11-12-33(52)50-40(32)55/h1-10,21-22,24,32,44H,11-20,23H2,(H,45,53)(H,50,52,55)(H2,46,47,48,49)","YUNXARYSBTUJHY-UHFFFAOYSA-N"
"2833","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","853.289","852.263417192","3.82","61","7","14","5","21","232.27","C42H41ClN8O10","InChI=1S/C42H41ClN8O10/c43-30-21-26(61-25-5-2-1-3-6-25)9-10-27(30)37(54)29-22-46-38-36(29)39(49-24-48-38)47-23-34(53)45-14-16-59-18-20-60-19-17-58-15-13-44-31-8-4-7-28-35(31)42(57)51(41(28)56)32-11-12-33(52)50-40(32)55/h1-10,21-22,24,32,44H,11-20,23H2,(H,45,53)(H,50,52,55)(H2,46,47,48,49)","YUNXARYSBTUJHY-UHFFFAOYSA-N"
"2834","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","9.4","66.5","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","2203.5","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","897.342","896.28963194","3.67","64","7","15","5","24","241.5","C44H45ClN8O11","InChI=1S/C44H45ClN8O11/c45-32-23-28(64-27-5-2-1-3-6-27)9-10-29(32)39(56)31-24-48-40-38(31)41(51-26-50-40)49-25-36(55)47-14-16-61-18-20-63-22-21-62-19-17-60-15-13-46-33-8-4-7-30-37(33)44(59)53(43(30)58)34-11-12-35(54)52-42(34)57/h1-10,23-24,26,34,46H,11-22,25H2,(H,47,55)(H,52,54,57)(H2,48,49,50,51)","IVICRPGKKOLGDE-UHFFFAOYSA-N"
"2834","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","52.7","68.6","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","897.342","896.28963194","3.67","64","7","15","5","24","241.5","C44H45ClN8O11","InChI=1S/C44H45ClN8O11/c45-32-23-28(64-27-5-2-1-3-6-27)9-10-29(32)39(56)31-24-48-40-38(31)41(51-26-50-40)49-25-36(55)47-14-16-61-18-20-63-22-21-62-19-17-60-15-13-46-33-8-4-7-30-37(33)44(59)53(43(30)58)34-11-12-35(54)52-42(34)57/h1-10,23-24,26,34,46H,11-22,25H2,(H,47,55)(H,52,54,57)(H2,48,49,50,51)","IVICRPGKKOLGDE-UHFFFAOYSA-N"
"2835","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","8.1","72.4","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","1209.5","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","63.3","Inhibit proliferation of TMD8 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","941.395","940.315846688","3.52","67","7","16","5","27","250.73","C46H49ClN8O12","InChI=1S/C46H49ClN8O12/c47-34-25-30(67-29-5-2-1-3-6-29)9-10-31(34)41(58)33-26-50-42-40(33)43(53-28-52-42)51-27-38(57)49-14-16-63-18-20-65-22-24-66-23-21-64-19-17-62-15-13-48-35-8-4-7-32-39(35)46(61)55(45(32)60)36-11-12-37(56)54-44(36)59/h1-10,25-26,28,36,48H,11-24,27H2,(H,49,57)(H,54,56,59)(H2,50,51,52,53)","SVBNVWQRLLLMHI-UHFFFAOYSA-N"
"2835","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","80.4","88.4","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1689.3","Inhibit proliferation of TMD8 (BTK C481S) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","941.395","940.315846688","3.52","67","7","16","5","27","250.73","C46H49ClN8O12","InChI=1S/C46H49ClN8O12/c47-34-25-30(67-29-5-2-1-3-6-29)9-10-31(34)41(58)33-26-50-42-40(33)43(53-28-52-42)51-27-38(57)49-14-16-63-18-20-65-22-24-66-23-21-64-19-17-62-15-13-48-35-8-4-7-32-39(35)46(61)55(45(32)60)36-11-12-37(56)54-44(36)59/h1-10,25-26,28,36,48H,11-24,27H2,(H,49,57)(H,54,56,59)(H2,50,51,52,53)","SVBNVWQRLLLMHI-UHFFFAOYSA-N"
"2836","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","8.3","92.4","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","1390.5","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","104.5","Inhibit proliferation of TMD8 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","985.448","984.342061436","3.37","70","7","17","5","30","259.96","C48H53ClN8O13","InChI=1S/C48H53ClN8O13/c49-36-27-32(70-31-5-2-1-3-6-31)9-10-33(36)43(60)35-28-52-44-42(35)45(55-30-54-44)53-29-40(59)51-14-16-65-18-20-67-22-24-69-26-25-68-23-21-66-19-17-64-15-13-50-37-8-4-7-34-41(37)48(63)57(47(34)62)38-11-12-39(58)56-46(38)61/h1-10,27-28,30,38,50H,11-26,29H2,(H,51,59)(H,56,58,61)(H2,52,53,54,55)","WJQKJTMVUALADJ-UHFFFAOYSA-N"
"2836","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","52.3","84.8","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","750","Inhibit proliferation of TMD8 (BTK C481S) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","985.448","984.342061436","3.37","70","7","17","5","30","259.96","C48H53ClN8O13","InChI=1S/C48H53ClN8O13/c49-36-27-32(70-31-5-2-1-3-6-31)9-10-33(36)43(60)35-28-52-44-42(35)45(55-30-54-44)53-29-40(59)51-14-16-65-18-20-67-22-24-69-26-25-68-23-21-66-19-17-64-15-13-50-37-8-4-7-34-41(37)48(63)57(47(34)62)38-11-12-39(58)56-46(38)61/h1-10,27-28,30,38,50H,11-26,29H2,(H,51,59)(H,56,58,61)(H2,52,53,54,55)","WJQKJTMVUALADJ-UHFFFAOYSA-N"
"2837","Q06187","BTK","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","1029.501","1028.36827618","3.23","73","7","18","5","33","269.19","C50H57ClN8O14","InChI=1S/C50H57ClN8O14/c51-38-29-34(73-33-5-2-1-3-6-33)9-10-35(38)45(62)37-30-54-46-44(37)47(57-32-56-46)55-31-42(61)53-14-16-67-18-20-69-22-24-71-26-28-72-27-25-70-23-21-68-19-17-66-15-13-52-39-8-4-7-36-43(39)50(65)59(49(36)64)40-11-12-41(60)58-48(40)63/h1-10,29-30,32,40,52H,11-28,31H2,(H,53,61)(H,58,60,63)(H2,54,55,56,57)","HWQJFZYSBCIWBV-UHFFFAOYSA-N"
"2837","Q06187","BTK C481S","CRBN","","","O=C(CNC1=NC=NC2=C1C(C(=O)C1=CC=C(OC3=CC=CC=C3)C=C1Cl)=C[NH]2)NCCOCCOCCOCCOCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","1029.501","1028.36827618","3.23","73","7","18","5","33","269.19","C50H57ClN8O14","InChI=1S/C50H57ClN8O14/c51-38-29-34(73-33-5-2-1-3-6-33)9-10-35(38)45(62)37-30-54-46-44(37)47(57-32-56-46)55-31-42(61)53-14-16-67-18-20-69-22-24-71-26-28-72-27-25-70-23-21-68-19-17-66-15-13-52-39-8-4-7-36-43(39)50(65)59(49(36)64)40-11-12-41(60)58-48(40)63/h1-10,29-30,32,40,52H,11-28,31H2,(H,53,61)(H,58,60,63)(H2,54,55,56,57)","HWQJFZYSBCIWBV-UHFFFAOYSA-N"
"2838","Q06187","BTK","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","","","","","","23","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","832.318","831.289572364","6.11","60","8","11","6","14","216.61","C43H42ClN9O7","InChI=1S/C43H42ClN9O7/c44-31-21-27(60-26-7-2-1-3-8-26)15-16-28(31)37(55)30-22-47-38-36(30)39(49-23-48-38)50-24-11-13-25(14-12-24)51-43(59)46-20-5-4-19-45-32-10-6-9-29-35(32)42(58)53(41(29)57)33-17-18-34(54)52-40(33)56/h1-3,6-10,15-16,21-25,33,45H,4-5,11-14,17-20H2,(H2,46,51,59)(H,52,54,56)(H2,47,48,49,50)/t24-,25+,33?","WTJIDAVQUKNWMS-YAUGJHQHSA-N"
"2838","Q06187","BTK C481S","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","832.318","831.289572364","6.11","60","8","11","6","14","216.61","C43H42ClN9O7","InChI=1S/C43H42ClN9O7/c44-31-21-27(60-26-7-2-1-3-8-26)15-16-28(31)37(55)30-22-47-38-36(30)39(49-23-48-38)50-24-11-13-25(14-12-24)51-43(59)46-20-5-4-19-45-32-10-6-9-29-35(32)42(58)53(41(29)57)33-17-18-34(54)52-40(33)56/h1-3,6-10,15-16,21-25,33,45H,4-5,11-14,17-20H2,(H2,46,51,59)(H,52,54,56)(H2,47,48,49,50)/t24-,25+,33?","WTJIDAVQUKNWMS-YAUGJHQHSA-N"
"2839","Q06187","BTK","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","","","","","","15.5","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","892.37","891.310701732","5.1","64","8","13","6","18","235.07","C45H46ClN9O9","InChI=1S/C45H46ClN9O9/c46-33-23-29(64-28-5-2-1-3-6-28)13-14-30(33)39(57)32-24-49-40-38(32)41(51-25-50-40)52-26-9-11-27(12-10-26)53-45(61)48-18-20-63-22-21-62-19-17-47-34-8-4-7-31-37(34)44(60)55(43(31)59)35-15-16-36(56)54-42(35)58/h1-8,13-14,23-27,35,47H,9-12,15-22H2,(H2,48,53,61)(H,54,56,58)(H2,49,50,51,52)/t26-,27+,35?","QLIDOUZNZPXVKV-BJUSXVRCSA-N"
"2839","Q06187","BTK C481S","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","892.37","891.310701732","5.1","64","8","13","6","18","235.07","C45H46ClN9O9","InChI=1S/C45H46ClN9O9/c46-33-23-29(64-28-5-2-1-3-6-28)13-14-30(33)39(57)32-24-49-40-38(32)41(51-25-50-40)52-26-9-11-27(12-10-26)53-45(61)48-18-20-63-22-21-62-19-17-47-34-8-4-7-31-37(34)44(60)55(43(31)59)35-15-16-36(56)54-42(35)58/h1-8,13-14,23-27,35,47H,9-12,15-22H2,(H2,48,53,61)(H,54,56,58)(H2,49,50,51,52)/t26-,27+,35?","QLIDOUZNZPXVKV-BJUSXVRCSA-N"
"2840","Q06187","BTK","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","32.3","76.9","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","22.3","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","936.423","935.33691648","4.95","67","8","14","6","21","244.3","C47H50ClN9O10","InChI=1S/C47H50ClN9O10/c48-35-25-31(67-30-5-2-1-3-6-30)13-14-32(35)41(59)34-26-51-42-40(34)43(53-27-52-42)54-28-9-11-29(12-10-28)55-47(63)50-18-20-65-22-24-66-23-21-64-19-17-49-36-8-4-7-33-39(36)46(62)57(45(33)61)37-15-16-38(58)56-44(37)60/h1-8,13-14,25-29,37,49H,9-12,15-24H2,(H2,50,55,63)(H,56,58,60)(H2,51,52,53,54)/t28-,29+,37?","HTWXOMYINZDUGN-JNLNXYSYSA-N"
"2840","Q06187","BTK C481S","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","30.1","84.3","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","936.423","935.33691648","4.95","67","8","14","6","21","244.3","C47H50ClN9O10","InChI=1S/C47H50ClN9O10/c48-35-25-31(67-30-5-2-1-3-6-30)13-14-32(35)41(59)34-26-51-42-40(34)43(53-27-52-42)54-28-9-11-29(12-10-28)55-47(63)50-18-20-65-22-24-66-23-21-64-19-17-49-36-8-4-7-33-39(36)46(62)57(45(33)61)37-15-16-38(58)56-44(37)60/h1-8,13-14,25-29,37,49H,9-12,15-24H2,(H2,50,55,63)(H,56,58,60)(H2,51,52,53,54)/t28-,29+,37?","HTWXOMYINZDUGN-JNLNXYSYSA-N"
"2841","Q06187","BTK","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","12.1","78","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","6.9","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","39.5","Inhibit proliferation of TMD8 cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","980.476","979.363131228","4.8","70","8","15","6","24","253.53","C49H54ClN9O11","InChI=1S/C49H54ClN9O11/c50-37-27-33(70-32-5-2-1-3-6-32)13-14-34(37)43(61)36-28-53-44-42(36)45(55-29-54-44)56-30-9-11-31(12-10-30)57-49(65)52-18-20-67-22-24-69-26-25-68-23-21-66-19-17-51-38-8-4-7-35-41(38)48(64)59(47(35)63)39-15-16-40(60)58-46(39)62/h1-8,13-14,27-31,39,51H,9-12,15-26H2,(H2,52,57,65)(H,58,60,62)(H2,53,54,55,56)/t30-,31+,39?","QJZSKXPDZKWNIF-ZMZOSUEXSA-N"
"2841","Q06187","BTK C481S","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","37.9","83.5","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","290.1","Inhibit proliferation of TMD8 (BTK C481S) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","980.476","979.363131228","4.8","70","8","15","6","24","253.53","C49H54ClN9O11","InChI=1S/C49H54ClN9O11/c50-37-27-33(70-32-5-2-1-3-6-32)13-14-34(37)43(61)36-28-53-44-42(36)45(55-29-54-44)56-30-9-11-31(12-10-30)57-49(65)52-18-20-67-22-24-69-26-25-68-23-21-66-19-17-51-38-8-4-7-35-41(38)48(64)59(47(35)63)39-15-16-40(60)58-46(39)62/h1-8,13-14,27-31,39,51H,9-12,15-26H2,(H2,52,57,65)(H,58,60,62)(H2,53,54,55,56)/t30-,31+,39?","QJZSKXPDZKWNIF-ZMZOSUEXSA-N"
"2842","Q06187","BTK","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","41.9","93","Degradation of BTK in JeKo-1 cells after 24 h treatment","","","56.4","Inhibition of BTK","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45.7","Inhibit proliferation of TMD8 cells","","","","","","","","","","","<0.53","Caco-2 A2B assay","7.5","Caco-2 B2A assay","10.1016/j.ejmech.2021.113820","1024.529","1023.38934598","4.65","73","8","16","6","27","262.76","C51H58ClN9O12","InChI=1S/C51H58ClN9O12/c52-39-29-35(73-34-5-2-1-3-6-34)13-14-36(39)45(63)38-30-55-46-44(38)47(57-31-56-46)58-32-9-11-33(12-10-32)59-51(67)54-18-20-69-22-24-71-26-28-72-27-25-70-23-21-68-19-17-53-40-8-4-7-37-43(40)50(66)61(49(37)65)41-15-16-42(62)60-48(41)64/h1-8,13-14,29-33,41,53H,9-12,15-28H2,(H2,54,59,67)(H,60,62,64)(H2,55,56,57,58)/t32-,33+,41?","OIAOFDRZXBDDRR-HYKUANOISA-N"
"2842","Q06187","BTK C481S","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCOCCOCCOCCOCCOCCNC(=O)N[C@H]4CC[C@@H](NC5=NC=NC6=C5C(C(=O)C5=CC=C(OC7=CC=CC=C7)C=C5Cl)=C[NH]6)CC4)=C3C2=O)C(=O)N1","42.9","90.7","Degradation of BTK C481S in TMD8 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","253.5","Inhibit proliferation of TMD8 (BTK C481S) cells","","","","","","","","","","","","","","","10.1016/j.ejmech.2021.113820","1024.529","1023.38934598","4.65","73","8","16","6","27","262.76","C51H58ClN9O12","InChI=1S/C51H58ClN9O12/c52-39-29-35(73-34-5-2-1-3-6-34)13-14-36(39)45(63)38-30-55-46-44(38)47(57-31-56-46)58-32-9-11-33(12-10-32)59-51(67)54-18-20-69-22-24-71-26-28-72-27-25-70-23-21-68-19-17-53-40-8-4-7-37-43(40)50(66)61(49(37)65)41-15-16-42(62)60-48(41)64/h1-8,13-14,29-33,41,53H,9-12,15-28H2,(H2,54,59,67)(H,60,62,64)(H2,55,56,57,58)/t32-,33+,41?","OIAOFDRZXBDDRR-HYKUANOISA-N"
"2843","Q9UBN7","HDAC6","CRBN","","","O=C(CCCO/N=C1C(=C2/C(=O)N(CC3=CN(CCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C3=CC=CC=C23)/NC2=CC=CC=C/12)NO","108.9","88","Degradation of HDAC6 in K562 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00681","802.805","802.282322796","1.71","59","8","15","5","15","238.78","C40H38N10O9","InChI=1S/C40H38N10O9/c51-31-15-14-30(37(53)43-31)50-38(54)26-9-5-11-28(33(26)40(50)56)41-16-19-58-20-17-48-21-23(44-47-48)22-49-29-12-4-2-8-25(29)34(39(49)55)36-35(24-7-1-3-10-27(24)42-36)46-59-18-6-13-32(52)45-57/h1-5,7-12,21,30,41-42,57H,6,13-20,22H2,(H,45,52)(H,43,51,53)/b36-34-,46-35+","DLBCMVGHLAVPJQ-ZQEKUULESA-N"
"2844","Q9UBN7","HDAC6","CRBN","","","O=C(CCCO/N=C1C(=C2/C(=O)N(CC3=CN(CCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C3=CC=CC=C23)/NC2=CC=CC=C/12)NO","","25","Degradation of HDAC6 in K562 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00681","846.858","846.308537544","1.57","62","8","16","5","18","248.01","C42H42N10O10","InChI=1S/C42H42N10O10/c53-33-15-14-32(39(55)45-33)52-40(56)28-9-5-11-30(35(28)42(52)58)43-16-19-60-21-22-61-20-17-50-23-25(46-49-50)24-51-31-12-4-2-8-27(31)36(41(51)57)38-37(26-7-1-3-10-29(26)44-38)48-62-18-6-13-34(54)47-59/h1-5,7-12,23,32,43-44,59H,6,13-22,24H2,(H,47,54)(H,45,53,55)/b38-36-,48-37+","MPFMOTZSJQYYCE-JMYOWPDWSA-N"
"2845","Q9UBN7","HDAC6","CRBN","","","O=C(CCCO/N=C1C(=C2/C(=O)N(CC3=CN(CCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C3=CC=CC=C23)/NC2=CC=CC=C/12)NO","","6.3","Degradation of HDAC6 in K562 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00681","890.911","890.334752292","1.42","65","8","17","5","21","257.24","C44H46N10O11","InChI=1S/C44H46N10O11/c55-35-15-14-34(41(57)47-35)54-42(58)30-9-5-11-32(37(30)44(54)60)45-16-19-62-21-23-64-24-22-63-20-17-52-25-27(48-51-52)26-53-33-12-4-2-8-29(33)38(43(53)59)40-39(28-7-1-3-10-31(28)46-40)50-65-18-6-13-36(56)49-61/h1-5,7-12,25,34,45-46,61H,6,13-24,26H2,(H,49,56)(H,47,55,57)/b40-38-,50-39+","VSESTTCSINIKPR-GHVOOOEOSA-N"
"2846","Q9UBN7","HDAC6","CRBN","","","O=C(CCCO/N=C1C(=C2/C(=O)N(CC3=CN(CCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C3=CC=CC=C23)/NC2=CC=CC=C/12)NO","","17","Degradation of HDAC6 in K562 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00681","934.964","934.36096704","1.27","68","8","18","5","24","266.47","C46H50N10O12","InChI=1S/C46H50N10O12/c57-37-15-14-36(43(59)49-37)56-44(60)32-9-5-11-34(39(32)46(56)62)47-16-19-64-21-23-66-25-26-67-24-22-65-20-17-54-27-29(50-53-54)28-55-35-12-4-2-8-31(35)40(45(55)61)42-41(30-7-1-3-10-33(30)48-42)52-68-18-6-13-38(58)51-63/h1-5,7-12,27,36,47-48,63H,6,13-26,28H2,(H,51,58)(H,49,57,59)/b42-40-,52-41+","URAWSEZNADEPFF-FHWUSBBXSA-N"
"2847","Q9UBN7","HDAC6","CRBN","","","O=C(CCCO/N=C1C(=C2/C(=O)N(CC3=CN(CCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)N=N3)C3=CC=CC=C23)/NC2=CC=CC=C/12)NO","","42","Degradation of HDAC6 in K562 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00681","979.017","978.387181788","1.12","71","8","19","5","27","275.7","C48H54N10O13","InChI=1S/C48H54N10O13/c59-39-15-14-38(45(61)51-39)58-46(62)34-9-5-11-36(41(34)48(58)64)49-16-19-66-21-23-68-25-27-70-28-26-69-24-22-67-20-17-56-29-31(52-55-56)30-57-37-12-4-2-8-33(37)42(47(57)63)44-43(32-7-1-3-10-35(32)50-44)54-71-18-6-13-40(60)53-65/h1-5,7-12,29,38,49-50,65H,6,13-28,30H2,(H,53,60)(H,51,59,61)/b44-42-,54-43+","SVVSCTXCDCJYGB-CORQSUHESA-N"
"2848","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","1.55","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<0.26","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","832.904","832.28636262","1.84","60","8","14","5","15","257.27","C40H40N12O7S","InChI=1S/C40H40N12O7S/c1-2-60(58,59)50-22-40(23-50,15-16-41)51-21-25(20-45-51)33-28-14-19-43-34(28)49-39(48-33)46-26-10-8-24(9-11-26)35(54)44-18-4-3-17-42-29-7-5-6-27-32(29)38(57)52(37(27)56)30-12-13-31(53)47-36(30)55/h5-11,14,19-21,30,42H,2-4,12-13,15,17-18,22-23H2,1H3,(H,44,54)(H,47,53,55)(H2,43,46,48,49)","XTSGMNYQSRAKGD-UHFFFAOYSA-N"
"2848","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","1.55","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<0.26","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","832.904","832.28636262","1.84","60","8","14","5","15","257.27","C40H40N12O7S","InChI=1S/C40H40N12O7S/c1-2-60(58,59)50-22-40(23-50,15-16-41)51-21-25(20-45-51)33-28-14-19-43-34(28)49-39(48-33)46-26-10-8-24(9-11-26)35(54)44-18-4-3-17-42-29-7-5-6-27-32(29)38(57)52(37(27)56)30-12-13-31(53)47-36(30)55/h5-11,14,19-21,30,42H,2-4,12-13,15,17-18,22-23H2,1H3,(H,44,54)(H,47,53,55)(H2,43,46,48,49)","XTSGMNYQSRAKGD-UHFFFAOYSA-N"
"2848","O60674","JAK2","CRBN","","SJ001005354","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.54","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","832.904","832.28636262","1.84","60","8","14","5","15","257.27","C40H40N12O7S","InChI=1S/C40H40N12O7S/c1-2-60(58,59)50-22-40(23-50,15-16-41)51-21-25(20-45-51)33-28-14-19-43-34(28)49-39(48-33)46-26-10-8-24(9-11-26)35(54)44-18-4-3-17-42-29-7-5-6-27-32(29)38(57)52(37(27)56)30-12-13-31(53)47-36(30)55/h5-11,14,19-21,30,42H,2-4,12-13,15,17-18,22-23H2,1H3,(H,44,54)(H,47,53,55)(H2,43,46,48,49)","XTSGMNYQSRAKGD-UHFFFAOYSA-N"
"2849","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","3.81","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","51.7","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","833.888","833.270378208","1.28","60","8","14","4","15","254.47","C40H39N11O8S","InChI=1S/C40H39N11O8S/c1-2-60(57,58)49-22-40(23-49,15-16-41)50-21-25(20-44-50)33-28-14-18-42-34(28)48-39(47-33)45-26-10-8-24(9-11-26)35(53)43-17-3-4-19-59-30-7-5-6-27-32(30)38(56)51(37(27)55)29-12-13-31(52)46-36(29)54/h5-11,14,18,20-21,29H,2-4,12-13,15,17,19,22-23H2,1H3,(H,43,53)(H,46,52,54)(H2,42,45,47,48)","RHRPJQJOBDOJKU-UHFFFAOYSA-N"
"2849","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","3.81","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","51.7","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","833.888","833.270378208","1.28","60","8","14","4","15","254.47","C40H39N11O8S","InChI=1S/C40H39N11O8S/c1-2-60(57,58)49-22-40(23-49,15-16-41)50-21-25(20-44-50)33-28-14-18-42-34(28)48-39(47-33)45-26-10-8-24(9-11-26)35(53)43-17-3-4-19-59-30-7-5-6-27-32(30)38(56)51(37(27)55)29-12-13-31(52)46-36(29)54/h5-11,14,18,20-21,29H,2-4,12-13,15,17,19,22-23H2,1H3,(H,43,53)(H,46,52,54)(H2,42,45,47,48)","RHRPJQJOBDOJKU-UHFFFAOYSA-N"
"2850","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NC5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","21","","Degradation of JAK2 in MHH-CALL-4 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","20.2","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<0.2","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","844.915","844.28636262","1.27","61","9","14","4","11","248.48","C41H40N12O7S","InChI=1S/C41H40N12O7S/c1-2-61(59,60)51-22-41(23-51,14-15-42)52-21-25(20-44-52)34-30-11-16-43-35(30)49-40(48-34)46-26-5-3-24(4-6-26)36(55)45-27-12-17-50(18-13-27)28-7-8-29-31(19-28)39(58)53(38(29)57)32-9-10-33(54)47-37(32)56/h3-8,11,16,19-21,27,32H,2,9-10,12-14,17-18,22-23H2,1H3,(H,45,55)(H,47,54,56)(H2,43,46,48,49)","QENXNFNQQOSOIZ-UHFFFAOYSA-N"
"2850","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NC5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","20.2","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","<0.2","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","844.915","844.28636262","1.27","61","9","14","4","11","248.48","C41H40N12O7S","InChI=1S/C41H40N12O7S/c1-2-61(59,60)51-22-41(23-51,14-15-42)52-21-25(20-44-52)34-30-11-16-43-35(30)49-40(48-34)46-26-5-3-24(4-6-26)36(55)45-27-12-17-50(18-13-27)28-7-8-29-31(19-28)39(58)53(38(29)57)32-9-10-33(54)47-37(32)56/h3-8,11,16,19-21,27,32H,2,9-10,12-14,17-18,22-23H2,1H3,(H,45,55)(H,47,54,56)(H2,43,46,48,49)","QENXNFNQQOSOIZ-UHFFFAOYSA-N"
"2851","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCN5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","0.31","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.3","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","873.957","873.312911716","0.53","63","9","15","4","13","251.72","C42H43N13O7S","InChI=1S/C42H43N13O7S/c1-2-63(61,62)53-24-42(25-53,12-13-43)54-23-27(22-46-54)35-31-11-14-44-36(31)50-41(49-35)47-28-5-3-26(4-6-28)37(57)45-15-16-51-17-19-52(20-18-51)29-7-8-30-32(21-29)40(60)55(39(30)59)33-9-10-34(56)48-38(33)58/h3-8,11,14,21-23,33H,2,9-10,12,15-20,24-25H2,1H3,(H,45,57)(H,48,56,58)(H2,44,47,49,50)","PURCRNBCKBOXFH-UHFFFAOYSA-N"
"2851","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCN5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","0.31","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8.3","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","873.957","873.312911716","0.53","63","9","15","4","13","251.72","C42H43N13O7S","InChI=1S/C42H43N13O7S/c1-2-63(61,62)53-24-42(25-53,12-13-43)54-23-27(22-46-54)35-31-11-14-44-36(31)50-41(49-35)47-28-5-3-26(4-6-28)37(57)45-15-16-51-17-19-52(20-18-51)29-7-8-30-32(21-29)40(60)55(39(30)59)33-9-10-34(56)48-38(33)58/h3-8,11,14,21-23,33H,2,9-10,12,15-20,24-25H2,1H3,(H,45,57)(H,48,56,58)(H2,44,47,49,50)","PURCRNBCKBOXFH-UHFFFAOYSA-N"
"2851","O60674","JAK2","CRBN","","SJ001008030","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCN5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","122","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","873.957","873.312911716","0.53","63","9","15","4","13","251.72","C42H43N13O7S","InChI=1S/C42H43N13O7S/c1-2-63(61,62)53-24-42(25-53,12-13-43)54-23-27(22-46-54)35-31-11-14-44-36(31)50-41(49-35)47-28-5-3-26(4-6-28)37(57)45-15-16-51-17-19-52(20-18-51)29-7-8-30-32(21-29)40(60)55(39(30)59)33-9-10-34(56)48-38(33)58/h3-8,11,14,21-23,33H,2,9-10,12,15-20,24-25H2,1H3,(H,45,57)(H,48,56,58)(H2,44,47,49,50)","PURCRNBCKBOXFH-UHFFFAOYSA-N"
"2852","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCNC5=CC=CC(C6CCC(=O)NC6=O)=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","14","","Degradation of JAK2 in MHH-CALL-4 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","1.13","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.43","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","763.885","763.301284412","2.18","55","7","12","5","15","219.89","C38H41N11O5S","InChI=1S/C38H41N11O5S/c1-2-55(53,54)48-23-38(24-48,15-16-39)49-22-27(21-43-49)33-31-14-19-41-34(31)47-37(46-33)44-28-10-8-25(9-11-28)35(51)42-18-4-3-17-40-29-7-5-6-26(20-29)30-12-13-32(50)45-36(30)52/h5-11,14,19-22,30,40H,2-4,12-13,15,17-18,23-24H2,1H3,(H,42,51)(H,45,50,52)(H2,41,44,46,47)","YMDKCHNRIDZCIK-UHFFFAOYSA-N"
"2852","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCNC5=CC=CC(C6CCC(=O)NC6=O)=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","1.13","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.43","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","763.885","763.301284412","2.18","55","7","12","5","15","219.89","C38H41N11O5S","InChI=1S/C38H41N11O5S/c1-2-55(53,54)48-23-38(24-48,15-16-39)49-22-27(21-43-49)33-31-14-19-41-34(31)47-37(46-33)44-28-10-8-25(9-11-28)35(51)42-18-4-3-17-40-29-7-5-6-26(20-29)30-12-13-32(50)45-36(30)52/h5-11,14,19-22,30,40H,2-4,12-13,15,17-18,23-24H2,1H3,(H,42,51)(H,45,50,52)(H2,41,44,46,47)","YMDKCHNRIDZCIK-UHFFFAOYSA-N"
"2853","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=C(C6CCC(=O)NC6=O)C=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","17","","Degradation of JAK2 in MHH-CALL-4 cells after 24 h treatment","","","","","","","0.14","Kd was assessed by KINOMEscan Assay","","","","","","","","","","","19.6","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.03","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","764.869","764.2853","2.17","55","7","12","4","15","217.09","C38H40N10O6S","InChI=1S/C38H40N10O6S/c1-2-55(52,53)47-23-38(24-47,16-17-39)48-22-27(21-42-48)33-31-15-19-40-34(31)46-37(45-33)43-28-9-5-26(6-10-28)35(50)41-18-3-4-20-54-29-11-7-25(8-12-29)30-13-14-32(49)44-36(30)51/h5-12,15,19,21-22,30H,2-4,13-14,16,18,20,23-24H2,1H3,(H,41,50)(H,44,49,51)(H2,40,43,45,46)","JQXUGPKGNONGRJ-UHFFFAOYSA-N"
"2853","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=C(C6CCC(=O)NC6=O)C=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","0.31","Kd was assessed by KINOMEscan Assay","","","","","","","","","","","19.6","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.03","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","764.869","764.2853","2.17","55","7","12","4","15","217.09","C38H40N10O6S","InChI=1S/C38H40N10O6S/c1-2-55(52,53)47-23-38(24-47,16-17-39)48-22-27(21-42-48)33-31-15-19-40-34(31)46-37(45-33)43-28-9-5-26(6-10-28)35(50)41-18-3-4-20-54-29-11-7-25(8-12-29)30-13-14-32(49)44-36(30)51/h5-12,15,19,21-22,30H,2-4,13-14,16,18,20,23-24H2,1H3,(H,41,50)(H,44,49,51)(H2,40,43,45,46)","JQXUGPKGNONGRJ-UHFFFAOYSA-N"
"2854","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=CC(C6CCC(=O)NC6=O)=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","19","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","764.869","764.2853","2.17","55","7","12","4","15","217.09","C38H40N10O6S","InChI=1S/C38H40N10O6S/c1-2-55(52,53)47-23-38(24-47,15-16-39)48-22-27(21-42-48)33-31-14-18-40-34(31)46-37(45-33)43-28-10-8-25(9-11-28)35(50)41-17-3-4-19-54-29-7-5-6-26(20-29)30-12-13-32(49)44-36(30)51/h5-11,14,18,20-22,30H,2-4,12-13,15,17,19,23-24H2,1H3,(H,41,50)(H,44,49,51)(H2,40,43,45,46)","CXJYSNHTGSVIBV-UHFFFAOYSA-N"
"2854","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCCOC5=CC=CC(C6CCC(=O)NC6=O)=C5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","19","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","764.869","764.2853","2.17","55","7","12","4","15","217.09","C38H40N10O6S","InChI=1S/C38H40N10O6S/c1-2-55(52,53)47-23-38(24-47,15-16-39)48-22-27(21-42-48)33-31-14-18-40-34(31)46-37(45-33)43-28-10-8-25(9-11-28)35(50)41-17-3-4-19-54-29-7-5-6-26(20-29)30-12-13-32(49)44-36(30)51/h5-11,14,18,20-22,30H,2-4,12-13,15,17,19,23-24H2,1H3,(H,41,50)(H,44,49,51)(H2,40,43,45,46)","CXJYSNHTGSVIBV-UHFFFAOYSA-N"
"2855","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NC5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","26","","Degradation of JAK2 in MHH-CALL-4 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","1045","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.25","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","775.896","775.301284412","2.16","56","8","12","4","11","211.1","C39H41N11O5S","InChI=1S/C39H41N11O5S/c1-2-56(54,55)49-23-39(24-49,16-17-40)50-22-27(21-42-50)34-32-13-18-41-35(32)47-38(46-34)44-28-7-3-26(4-8-28)36(52)43-29-14-19-48(20-15-29)30-9-5-25(6-10-30)31-11-12-33(51)45-37(31)53/h3-10,13,18,21-22,29,31H,2,11-12,14-16,19-20,23-24H2,1H3,(H,43,52)(H,45,51,53)(H2,41,44,46,47)","XKYDUBODDYBCNZ-UHFFFAOYSA-N"
"2855","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NC5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","1045","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.25","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","775.896","775.301284412","2.16","56","8","12","4","11","211.1","C39H41N11O5S","InChI=1S/C39H41N11O5S/c1-2-56(54,55)49-23-39(24-49,16-17-40)50-22-27(21-42-50)34-32-13-18-41-35(32)47-38(46-34)44-28-7-3-26(4-8-28)36(52)43-29-14-19-48(20-15-29)30-9-5-25(6-10-30)31-11-12-33(51)45-37(31)53/h3-10,13,18,21-22,29,31H,2,11-12,14-16,19-20,23-24H2,1H3,(H,43,52)(H,45,51,53)(H2,41,44,46,47)","XKYDUBODDYBCNZ-UHFFFAOYSA-N"
"2856","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCN5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","0.45","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","113","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","804.938","804.327833508","1.42","58","8","13","4","13","214.34","C40H44N12O5S","InChI=1S/C40H44N12O5S/c1-2-58(56,57)51-25-40(26-51,14-15-41)52-24-29(23-44-52)35-33-13-16-42-36(33)48-39(47-35)45-30-7-3-28(4-8-30)37(54)43-17-18-49-19-21-50(22-20-49)31-9-5-27(6-10-31)32-11-12-34(53)46-38(32)55/h3-10,13,16,23-24,32H,2,11-12,14,17-22,25-26H2,1H3,(H,43,54)(H,46,53,55)(H2,42,45,47,48)","FTPOFCHJCWFAIM-UHFFFAOYSA-N"
"2856","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCN5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","0.45","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","113","Inhibit viability of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","804.938","804.327833508","1.42","58","8","13","4","13","214.34","C40H44N12O5S","InChI=1S/C40H44N12O5S/c1-2-58(56,57)51-25-40(26-51,14-15-41)52-24-29(23-44-52)35-33-13-16-42-36(33)48-39(47-35)45-30-7-3-28(4-8-30)37(54)43-17-18-49-19-21-50(22-20-49)31-9-5-27(6-10-31)32-11-12-34(53)46-38(32)55/h3-10,13,16,23-24,32H,2,11-12,14,17-22,25-26H2,1H3,(H,43,54)(H,46,53,55)(H2,42,45,47,48)","FTPOFCHJCWFAIM-UHFFFAOYSA-N"
"2857","P52333","JAK3","CRBN","","SJ10542","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCN5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","11","92","Degradation of JAK3 in PDX SJBALL020589 cells after 24 h treatment","","","","","","","0.056","Kd was assessed by KINOMEscan Assay","","","","","","","","","","","0.02","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24/86.4","Inhibit viability of PDX SJBALL020589/MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","818.965","818.343483572","1.78","59","8","13","4","14","214.34","C41H46N12O5S","InChI=1S/C41H46N12O5S/c1-2-59(57,58)52-26-41(27-52,15-16-42)53-25-30(24-45-53)36-34-14-18-43-37(34)49-40(48-36)46-31-8-4-29(5-9-31)38(55)44-17-3-19-50-20-22-51(23-21-50)32-10-6-28(7-11-32)33-12-13-35(54)47-39(33)56/h4-11,14,18,24-25,33H,2-3,12-13,15,17,19-23,26-27H2,1H3,(H,44,55)(H,47,54,56)(H2,43,46,48,49)","WBEBZVDAHMXWJN-UHFFFAOYSA-N"
"2857","O60674","JAK2","CRBN","","SJ10542","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCN5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","14/24","90/82","Degradation of JAK2 in PDX SJBALL020589/MHH-CALL-4 cells after 24 h treatment","","","","","","","0.022","Kd was assessed by KINOMEscan Assay","","","","","","","","","","","0.02","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","24/86.4","Inhibit viability of PDX SJBALL020589/MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","818.965","818.343483572","1.78","59","8","13","4","14","214.34","C41H46N12O5S","InChI=1S/C41H46N12O5S/c1-2-59(57,58)52-26-41(27-52,15-16-42)53-25-30(24-45-53)36-34-14-18-43-37(34)49-40(48-36)46-31-8-4-29(5-9-31)38(55)44-17-3-19-50-20-22-51(23-21-50)32-10-6-28(7-11-32)33-12-13-35(54)47-39(33)56/h4-11,14,18,24-25,33H,2-3,12-13,15,17,19-23,26-27H2,1H3,(H,44,55)(H,47,54,56)(H2,43,46,48,49)","WBEBZVDAHMXWJN-UHFFFAOYSA-N"
"2857","O60674","JAK2 R683G","CRBN","","SJ10542","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCN5CCN(C6=CC=C(C7CCC(=O)NC7=O)C=C6)CC5)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","74","","Degradation of JAK2 R683G in KOPN49 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","0.02","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1029","Inhibit viability of KOPN49 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","818.965","818.343483572","1.78","59","8","13","4","14","214.34","C41H46N12O5S","InChI=1S/C41H46N12O5S/c1-2-59(57,58)52-26-41(27-52,15-16-42)53-25-30(24-45-53)36-34-14-18-43-37(34)49-40(48-36)46-31-8-4-29(5-9-31)38(55)44-17-3-19-50-20-22-51(23-21-50)32-10-6-28(7-11-32)33-12-13-35(54)47-39(33)56/h4-11,14,18,24-25,33H,2-3,12-13,15,17,19-23,26-27H2,1H3,(H,44,55)(H,47,54,56)(H2,43,46,48,49)","WBEBZVDAHMXWJN-UHFFFAOYSA-N"
"2858","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=C4C=C[NH]C4=NC(NC4=CC=C(C(=O)NCCCN5CC6CC5CN6C5=CC=C(C6CCC(=O)NC6=O)C=C5)C=C4)=N3)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","23.9","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","830.976","830.343483572","2.04","60","9","13","4","14","214.34","C42H46N12O5S","InChI=1S/C42H46N12O5S/c1-2-60(58,59)52-25-42(26-52,15-16-43)54-22-29(21-46-54)37-35-14-18-44-38(35)50-41(49-37)47-30-8-4-28(5-9-30)39(56)45-17-3-19-51-23-33-20-32(51)24-53(33)31-10-6-27(7-11-31)34-12-13-36(55)48-40(34)57/h4-11,14,18,21-22,32-34H,2-3,12-13,15,17,19-20,23-26H2,1H3,(H,45,56)(H,48,55,57)(H2,44,47,49,50)","RSFUBQJFNCMAGS-UHFFFAOYSA-N"
"2858","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=C4C=C[NH]C4=NC(NC4=CC=C(C(=O)NCCCN5CC6CC5CN6C5=CC=C(C6CCC(=O)NC6=O)C=C5)C=C4)=N3)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","23.9","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","830.976","830.343483572","2.04","60","9","13","4","14","214.34","C42H46N12O5S","InChI=1S/C42H46N12O5S/c1-2-60(58,59)52-25-42(26-52,15-16-43)54-22-29(21-46-54)37-35-14-18-44-38(35)50-41(49-37)47-30-8-4-28(5-9-30)39(56)45-17-3-19-51-23-33-20-32(51)24-53(33)31-10-6-27(7-11-31)34-12-13-36(55)48-40(34)57/h4-11,14,18,21-22,32-34H,2-3,12-13,15,17,19-20,23-26H2,1H3,(H,45,56)(H,48,55,57)(H2,44,47,49,50)","RSFUBQJFNCMAGS-UHFFFAOYSA-N"
"2859","O60674","JAK2","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCN5CCC6(CC5)CCN(C5=CC=C(C7CCC(=O)NC7=O)C=C5)CC6)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","15","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","887.084","886.406083828","3.09","64","9","13","4","14","214.34","C46H54N12O5S","InChI=1S/C46H54N12O5S/c1-2-64(62,63)57-30-46(31-57,15-20-47)58-29-34(28-50-58)40-38-14-22-48-41(38)54-44(53-40)51-35-8-4-33(5-9-35)42(60)49-21-3-23-55-24-16-45(17-25-55)18-26-56(27-19-45)36-10-6-32(7-11-36)37-12-13-39(59)52-43(37)61/h4-11,14,22,28-29,37H,2-3,12-13,15-19,21,23-27,30-31H2,1H3,(H,49,60)(H,52,59,61)(H2,48,51,53,54)","NTHVTKVZITWROX-UHFFFAOYSA-N"
"2859","P52333","JAK3","CRBN","","","CCS(=O)(=O)N1CC(CC#N)(N2C=C(C3=NC(NC4=CC=C(C(=O)NCCCN5CCC6(CC5)CCN(C5=CC=C(C7CCC(=O)NC7=O)C=C5)CC6)C=C4)=NC4=C3C=C[NH]4)C=N2)C1","","","","","","","","","","","","","","","","","","","","","","15","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00650","887.084","886.406083828","3.09","64","9","13","4","14","214.34","C46H54N12O5S","InChI=1S/C46H54N12O5S/c1-2-64(62,63)57-30-46(31-57,15-20-47)58-29-34(28-50-58)40-38-14-22-48-41(38)54-44(53-40)51-35-8-4-33(5-9-35)42(60)49-21-3-23-55-24-16-45(17-25-55)18-26-56(27-19-45)36-10-6-32(7-11-36)37-12-13-39(59)52-43(37)61/h4-11,14,22,28-29,37H,2-3,12-13,15-19,21,23-27,30-31H2,1H3,(H,49,60)(H,52,59,61)(H2,48,51,53,54)","NTHVTKVZITWROX-UHFFFAOYSA-N"
"2860","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(C2CCN(CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2NS(C)(=O)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","370","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1043.758","1042.43241416","7.59","72","7","14","6","20","220.11","C52H67ClN10O7S2","InChI=1S/C52H67ClN10O7S2/c1-32(34-16-18-36(19-17-34)46-33(2)55-31-71-46)56-49(66)43-28-38(64)30-63(43)50(67)47(52(3,4)5)59-45(65)15-9-8-12-24-62-25-22-35(23-26-62)37-20-21-42(44(27-37)70-6)58-51-54-29-39(53)48(60-51)57-40-13-10-11-14-41(40)61-72(7,68)69/h10-11,13-14,16-21,27,29,31-32,35,38,43,47,61,64H,8-9,12,15,22-26,28,30H2,1-7H3,(H,56,66)(H,59,65)(H2,54,57,58,60)/t32-,38+,43-,47+/m0/s1","LWCAXNBXZPQKSD-LOLWDDHHSA-N"
"2861","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(C2CCN(CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2N(C)S(C)(=O)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","70","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1057.785","1056.44806423","7.77","73","7","14","5","20","211.32","C53H69ClN10O7S2","InChI=1S/C53H69ClN10O7S2/c1-33(35-17-19-37(20-18-35)47-34(2)56-32-72-47)57-50(67)44-29-39(65)31-64(44)51(68)48(53(3,4)5)60-46(66)16-10-9-13-25-63-26-23-36(24-27-63)38-21-22-42(45(28-38)71-7)59-52-55-30-40(54)49(61-52)58-41-14-11-12-15-43(41)62(6)73(8,69)70/h11-12,14-15,17-22,28,30,32-33,36,39,44,48,65H,9-10,13,16,23-27,29,31H2,1-8H3,(H,57,67)(H,60,66)(H2,55,58,59,61)/t33-,39+,44-,48+/m0/s1","JLWGCLJIWXUANI-WQWWALRQSA-N"
"2862","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","50","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1027.674","1026.44701521","7.54","71","7","14","5","19","194.25","C52H68ClN10O6PS","InChI=1S/C52H68ClN10O6PS/c1-33(35-17-19-36(20-18-35)46-34(2)55-32-71-46)56-49(66)42-29-38(64)31-63(42)50(67)47(52(3,4)5)59-45(65)16-10-9-13-23-61-24-26-62(27-25-61)37-21-22-40(43(28-37)69-6)58-51-54-30-39(53)48(60-51)57-41-14-11-12-15-44(41)70(7,8)68/h11-12,14-15,17-22,28,30,32-33,38,42,47,64H,9-10,13,16,23-27,29,31H2,1-8H3,(H,56,66)(H,59,65)(H2,54,57,58,60)/t33-,38+,42-,47+/m0/s1","PGNBEPVWKCSKAS-RZQFPGPRSA-N"
"2863","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","240","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1057.785","1056.44806423","8.57","73","7","15","5","20","211.32","C53H69ClN10O7S2","InChI=1S/C53H69ClN10O7S2/c1-33(2)73(69,70)45-15-12-11-14-42(45)58-49-40(54)30-55-52(61-49)59-41-22-21-38(28-44(41)71-8)63-26-24-62(25-27-63)23-13-9-10-16-46(66)60-48(53(5,6)7)51(68)64-31-39(65)29-43(64)50(67)57-34(3)36-17-19-37(20-18-36)47-35(4)56-32-72-47/h11-12,14-15,17-22,28,30,32-34,39,43,48,65H,9-10,13,16,23-27,29,31H2,1-8H3,(H,57,67)(H,60,66)(H2,55,58,59,61)/t34-,39+,43-,48+/m0/s1","JGZVZHAUKMEBKN-OESUUHGFSA-N"
"2864","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","370","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","999.62","998.415715078","6.83","69","7","14","5","17","194.25","C50H64ClN10O6PS","InChI=1S/C50H64ClN10O6PS/c1-31(33-15-17-34(18-16-33)44-32(2)53-30-69-44)54-47(64)40-27-36(62)29-61(40)48(65)45(50(3,4)5)57-43(63)14-11-21-59-22-24-60(25-23-59)35-19-20-38(41(26-35)67-6)56-49-52-28-37(51)46(58-49)55-39-12-9-10-13-42(39)68(7,8)66/h9-10,12-13,15-20,26,28,30-31,36,40,45,62H,11,14,21-25,27,29H2,1-8H3,(H,54,64)(H,57,63)(H2,52,55,56,58)/t31-,36+,40-,45+/m0/s1","CQYHZVXZWVBOLV-DKGDNKRPSA-N"
"2865","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","230","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1013.647","1012.43136514","7.19","70","7","14","5","18","194.25","C51H66ClN10O6PS","InChI=1S/C51H66ClN10O6PS/c1-32(34-16-18-35(19-17-34)45-33(2)54-31-70-45)55-48(65)41-28-37(63)30-62(41)49(66)46(51(3,4)5)58-44(64)15-11-12-22-60-23-25-61(26-24-60)36-20-21-39(42(27-36)68-6)57-50-53-29-38(52)47(59-50)56-40-13-9-10-14-43(40)69(7,8)67/h9-10,13-14,16-21,27,29,31-32,37,41,46,63H,11-12,15,22-26,28,30H2,1-8H3,(H,55,65)(H,58,64)(H2,53,56,57,59)/t32-,37+,41-,46+/m0/s1","PIVNHCZTKNSYDX-KXGURFEISA-N"
"2866","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","140","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1041.701","1040.46266527","8.09","72","7","14","5","20","194.25","C53H70ClN10O6PS","InChI=1S/C53H70ClN10O6PS/c1-34(36-18-20-37(21-19-36)47-35(2)56-33-72-47)57-50(67)43-30-39(65)32-64(43)51(68)48(53(3,4)5)60-46(66)17-11-9-10-14-24-62-25-27-63(28-26-62)38-22-23-41(44(29-38)70-6)59-52-55-31-40(54)49(61-52)58-42-15-12-13-16-45(42)71(7,8)69/h12-13,15-16,18-23,29,31,33-34,39,43,48,65H,9-11,14,17,24-28,30,32H2,1-8H3,(H,57,67)(H,60,66)(H2,55,58,59,61)/t34-,39+,43-,48+/m0/s1","VTNGOAUXHNQCSE-OESUUHGFSA-N"
"2867","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","8","","Degradation of EGFR del19/T790M/C797S in Ba/F3 cells after 3 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1055.728","1054.47831533","8.63","73","7","14","5","21","194.25","C54H72ClN10O6PS","InChI=1S/C54H72ClN10O6PS/c1-35(37-19-21-38(22-20-37)48-36(2)57-34-73-48)58-51(68)44-31-40(66)33-65(44)52(69)49(54(3,4)5)61-47(67)18-12-10-9-11-15-25-63-26-28-64(29-27-63)39-23-24-42(45(30-39)71-6)60-53-56-32-41(55)50(62-53)59-43-16-13-14-17-46(43)72(7,8)70/h13-14,16-17,19-24,30,32,34-35,40,44,49,66H,9-12,15,18,25-29,31,33H2,1-8H3,(H,58,68)(H,61,67)(H2,56,59,60,62)/t35-,40+,44-,49+/m0/s1","KSHZFKVXGRVRTM-XJLLBULKSA-N"
"2867","P00533","EGFR e19d","VHL","","","COC1=CC(N2CCN(CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","228.6","Inhibit growth of HCC827 EGFR del19 cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1055.728","1054.47831533","8.63","73","7","14","5","21","194.25","C54H72ClN10O6PS","InChI=1S/C54H72ClN10O6PS/c1-35(37-19-21-38(22-20-37)48-36(2)57-34-73-48)58-51(68)44-31-40(66)33-65(44)52(69)49(54(3,4)5)61-47(67)18-12-10-9-11-15-25-63-26-28-64(29-27-63)39-23-24-42(45(30-39)71-6)60-53-56-32-41(55)50(62-53)59-43-16-13-14-17-46(43)72(7,8)70/h13-14,16-17,19-24,30,32,34-35,40,44,49,66H,9-12,15,18,25-29,31,33H2,1-8H3,(H,58,68)(H,61,67)(H2,56,59,60,62)/t35-,40+,44-,49+/m0/s1","KSHZFKVXGRVRTM-XJLLBULKSA-N"
"2867","P00533","EGFR L858R/T790M","VHL","","","COC1=CC(N2CCN(CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1131","Inhibit growth of H1975 EGFR L858R/T790M cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1055.728","1054.47831533","8.63","73","7","14","5","21","194.25","C54H72ClN10O6PS","InChI=1S/C54H72ClN10O6PS/c1-35(37-19-21-38(22-20-37)48-36(2)57-34-73-48)58-51(68)44-31-40(66)33-65(44)52(69)49(54(3,4)5)61-47(67)18-12-10-9-11-15-25-63-26-28-64(29-27-63)39-23-24-42(45(30-39)71-6)60-53-56-32-41(55)50(62-53)59-43-16-13-14-17-46(43)72(7,8)70/h13-14,16-17,19-24,30,32,34-35,40,44,49,66H,9-12,15,18,25-29,31,33H2,1-8H3,(H,58,68)(H,61,67)(H2,56,59,60,62)/t35-,40+,44-,49+/m0/s1","KSHZFKVXGRVRTM-XJLLBULKSA-N"
"2868","P00533","EGFR del19/T790M/C797S","VHL","","","COC1=CC(N2CCN(CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","30","Inhibit growth of Ba/F3 EGFR del19/T790M/C797S cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00645","1069.755","1068.4939654","9.17","74","7","14","5","22","194.25","C55H74ClN10O6PS","InChI=1S/C55H74ClN10O6PS/c1-36(38-20-22-39(23-21-38)49-37(2)58-35-74-49)59-52(69)45-32-41(67)34-66(45)53(70)50(55(3,4)5)62-48(68)19-13-11-9-10-12-16-26-64-27-29-65(30-28-64)40-24-25-43(46(31-40)72-6)61-54-57-33-42(56)51(63-54)60-44-17-14-15-18-47(44)73(7,8)71/h14-15,17-18,20-25,31,33,35-36,41,45,50,67H,9-13,16,19,26-30,32,34H2,1-8H3,(H,59,69)(H,62,68)(H2,57,60,61,63)/t36-,41+,45-,50+/m0/s1","AAANIVVODIZQAG-NYJWCRJYSA-N"
"2869","P40763","STAT3","CRBN","","SD-91","NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#CC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)C3=CC4=CC(C(=O)P(=O)(O)O)=CC=C4[NH]3)C(=O)N12)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1","120/17/1200","","Degradation of STAT3 in MOLM-16/SU-DHL-1/SUP-M2 cells after 4/14/14 h treatment","","","","","","","28","BLI","5.5","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","170/2600/460","Inhibit growth of MOLM-16/SU-DHL-1/SUP-M2 cells","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00155","1136.169","1135.42046967","2.46","82","9","11","8","19","327.88","C59H62N9O13P","InChI=1S/C59H62N9O13P/c60-49(69)27-24-44(53(72)65-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37)62-56(75)48-25-22-40-29-30-66(34-46(58(77)68(40)48)63-54(73)45-32-39-31-38(21-23-43(39)61-45)59(78)82(79,80)81)51(71)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-67(57(41)76)47-26-28-50(70)64-55(47)74/h4-5,7-10,12,14-19,21,23,31-32,40,44,46-48,52,61H,1-3,11,20,22,24-30,33-34H2,(H2,60,69)(H,62,75)(H,63,73)(H,65,72)(H,64,70,74)(H2,79,80,81)/t40-,44+,46+,47?,48+/m1/s1","OHDMEJTVYXXZNQ-OPKPGBGESA-N"
"2870","P21802","FGFR2","CRBN","","DGY-09-037","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCCOC5=CC6=C7C(=CC=CC7=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)=NC=N2)=C1Cl","","","","","","51","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","953.841","952.282628412","5.11","67","8","14","4","15","216.97","C46H46Cl2N10O9","InChI=1S/C46H46Cl2N10O9/c1-55(46(64)54-42-40(47)33(65-2)22-34(66-3)41(42)48)36-23-35(50-25-51-36)52-27-8-10-28(11-9-27)57-17-15-56(16-18-57)24-38(60)49-14-5-19-67-29-20-26-6-4-7-30-39(26)31(21-29)45(63)58(44(30)62)32-12-13-37(59)53-43(32)61/h4,6-11,20-23,25,32H,5,12-19,24H2,1-3H3,(H,49,60)(H,54,64)(H,50,51,52)(H,53,59,61)","BSESSTWXMHAUJO-UHFFFAOYSA-N"
"2871","P21802","FGFR2","CRBN","","DGY-09-073","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCCCCOC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)=NC=N2)=C1Cl","","","","","","33","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","931.835","930.298278476","4.58","65","7","14","4","17","216.97","C44H48Cl2N10O9","InChI=1S/C44H48Cl2N10O9/c1-53(44(62)52-40-38(45)31(63-2)22-32(64-3)39(40)46)34-23-33(48-25-49-34)50-26-10-12-27(13-11-26)55-19-17-54(18-20-55)24-36(58)47-16-5-4-6-21-65-30-9-7-8-28-37(30)43(61)56(42(28)60)29-14-15-35(57)51-41(29)59/h7-13,22-23,25,29H,4-6,14-21,24H2,1-3H3,(H,47,58)(H,52,62)(H,48,49,50)(H,51,57,59)","FPOHQFPZOFIGNG-UHFFFAOYSA-N"
"2872","P21802","FGFR2","CRBN","","DGY-09-038","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCCCCCOC5=CC6=C7C(=CC=CC7=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)=NC=N2)=C1Cl","","","","","","63","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","995.922","994.329578604","6.18","70","8","14","4","18","216.97","C49H52Cl2N10O9","InChI=1S/C49H52Cl2N10O9/c1-58(49(67)57-45-43(50)36(68-2)25-37(69-3)44(45)51)39-26-38(53-28-54-39)55-30-11-13-31(14-12-30)60-20-18-59(19-21-60)27-41(63)52-17-6-4-5-7-22-70-32-23-29-9-8-10-33-42(29)34(24-32)48(66)61(47(33)65)35-15-16-40(62)56-46(35)64/h8-14,23-26,28,35H,4-7,15-22,27H2,1-3H3,(H,52,63)(H,57,67)(H,53,54,55)(H,56,62,64)","SDHHYHZXQFOIAW-UHFFFAOYSA-N"
"2873","P21802","FGFR2","CRBN","","DGY-09-036","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOC5=CC6=C7C(=CC=CC7=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)=NC=N2)=C1Cl","","","","","","54","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1027.92","1026.31940784","4.46","72","8","16","4","20","235.43","C49H52Cl2N10O11","InChI=1S/C49H52Cl2N10O11/c1-58(49(67)57-45-43(50)36(68-2)25-37(69-3)44(45)51)39-26-38(53-28-54-39)55-30-7-9-31(10-8-30)60-16-14-59(15-17-60)27-41(63)52-13-18-70-19-20-71-21-22-72-32-23-29-5-4-6-33-42(29)34(24-32)48(66)61(47(33)65)35-11-12-40(62)56-46(35)64/h4-10,23-26,28,35H,11-22,27H2,1-3H3,(H,52,63)(H,57,67)(H,53,54,55)(H,56,62,64)","HHJFZKQQXBSGNM-UHFFFAOYSA-N"
"2874","P21802","FGFR2","CRBN","","DGY-09-041","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCCOC5=CC6=C7C(=CC=CC7=C5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=C3)=NC=N2)=C1Cl","","","","","","23","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1071.973","1070.34562259","4.31","75","8","17","4","23","244.66","C51H56Cl2N10O12","InChI=1S/C51H56Cl2N10O12/c1-60(51(69)59-47-45(52)38(70-2)27-39(71-3)46(47)53)41-28-40(55-30-56-41)57-32-7-9-33(10-8-32)62-16-14-61(15-17-62)29-43(65)54-13-18-72-19-20-73-21-22-74-23-24-75-34-25-31-5-4-6-35-44(31)36(26-34)50(68)63(49(35)67)37-11-12-42(64)58-48(37)66/h4-10,25-28,30,37H,11-24,29H2,1-3H3,(H,54,65)(H,59,69)(H,55,56,57)(H,58,64,66)","JFSWWOCDWFNCIB-UHFFFAOYSA-N"
"2875","P21802","FGFR2","CRBN","","DGY-09-068","CCC(=O)NC1=CC=C(CN2C(=O)N(C3=CC(OC)=CC(OC)=C3)CC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCOC6=CC7=C8C(=CC=CC8=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=C4)N=C32)C=C1","","","","","","93","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1044.139","1043.42898702","4.75","77","10","15","4","18","237.28","C56H57N11O10","InChI=1S/C56H57N11O10/c1-4-47(68)59-37-11-9-34(10-12-37)31-66-51-36(32-65(56(66)74)40-26-41(75-2)28-42(27-40)76-3)30-58-55(62-51)60-38-13-15-39(16-14-38)64-22-20-63(21-23-64)33-49(70)57-19-6-24-77-43-25-35-7-5-8-44-50(35)45(29-43)54(73)67(53(44)72)46-17-18-48(69)61-52(46)71/h5,7-16,25-30,46H,4,6,17-24,31-33H2,1-3H3,(H,57,70)(H,59,68)(H,58,60,62)(H,61,69,71)","PAANDANLMSMAMR-UHFFFAOYSA-N"
"2876","P21802","FGFR2","CRBN","","DGY-09-074","CCC(=O)NC1=CC=C(CN2C(=O)N(C3=CC(OC)=CC(OC)=C3)CC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCCCCOC6=CC7=C8C(=CC=CC8=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=C4)N=C32)C=C1","","","","","","42","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1072.193","1071.46028715","5.47","79","10","15","4","20","237.28","C58H61N11O10","InChI=1S/C58H61N11O10/c1-4-49(70)61-39-13-11-36(12-14-39)33-68-53-38(34-67(58(68)76)42-28-43(77-2)30-44(29-42)78-3)32-60-57(64-53)62-40-15-17-41(18-16-40)66-24-22-65(23-25-66)35-51(72)59-21-6-5-7-26-79-45-27-37-9-8-10-46-52(37)47(31-45)56(75)69(55(46)74)48-19-20-50(71)63-54(48)73/h8-18,27-32,48H,4-7,19-26,33-35H2,1-3H3,(H,59,72)(H,61,70)(H,60,62,64)(H,63,71,73)","BKEHRFBIGKYCNA-UHFFFAOYSA-N"
"2877","P21802","FGFR2","CRBN","","DGY-09-077","CCC(=O)NC1=CC=C(CN2C(=O)N(C3=CC(OC)=CC(OC)=C3)CC3=CN=C(NC4=CC=C(N5CCN(CC(=O)NCCOCCOCCOC6=CC7=C8C(=CC=CC8=C6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)C=C4)N=C32)C=C1","","","","","","72","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1118.218","1117.46576646","4.1","82","10","17","4","23","255.74","C59H63N11O12","InChI=1S/C59H63N11O12/c1-4-50(71)62-40-10-8-37(9-11-40)34-69-54-39(35-68(59(69)77)43-29-44(78-2)31-45(30-43)79-3)33-61-58(65-54)63-41-12-14-42(15-13-41)67-21-19-66(20-22-67)36-52(73)60-18-23-80-24-25-81-26-27-82-46-28-38-6-5-7-47-53(38)48(32-46)57(76)70(56(47)75)49-16-17-51(72)64-55(49)74/h5-15,28-33,49H,4,16-27,34-36H2,1-3H3,(H,60,73)(H,62,71)(H,61,63,65)(H,64,72,74)","KKGUTKZKISBKGJ-UHFFFAOYSA-N"
"2878","P11362","FGFR1","VHL","","DGY-09-192","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","4.35","85","Degradation of FGFR1 in CCLP1 cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17","Inhibit proliferation of CCLP1 cells","","","","","","","","","","","","","","","10.1002/anie.202101328","1017.054","1015.36966959","6.81","70","7","14","5","15","206.72","C49H59Cl2N11O7S","InChI=1S/C49H59Cl2N11O7S/c1-28(30-9-11-31(12-10-30)44-29(2)54-27-70-44)55-46(65)35-21-34(63)24-62(35)47(66)45(49(3,4)5)57-40(64)25-60-17-19-61(20-18-60)33-15-13-32(14-16-33)56-38-23-39(53-26-52-38)59(6)48(67)58-43-41(50)36(68-7)22-37(69-8)42(43)51/h9-16,22-23,26-28,34-35,45,63H,17-21,24-25H2,1-8H3,(H,55,65)(H,57,64)(H,58,67)(H,52,53,56)/t28-,34+,35-,45+/m0/s1","WDBUEMWHXKHQNB-AURZXHAXSA-N"
"2878","P21802","FGFR2","VHL","","DGY-09-192","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","70","74","Degradation of FGFR2 in KATO III cells after 6 h treatment","","","34","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1","Inhibit proliferation of KATO III cells","","","","","","","","","","","","","","","10.1002/anie.202101328","1017.054","1015.36966959","6.81","70","7","14","5","15","206.72","C49H59Cl2N11O7S","InChI=1S/C49H59Cl2N11O7S/c1-28(30-9-11-31(12-10-30)44-29(2)54-27-70-44)55-46(65)35-21-34(63)24-62(35)47(66)45(49(3,4)5)57-40(64)25-60-17-19-61(20-18-60)33-15-13-32(14-16-33)56-38-23-39(53-26-52-38)59(6)48(67)58-43-41(50)36(68-7)22-37(69-8)42(43)51/h9-16,22-23,26-28,34-35,45,63H,17-21,24-25H2,1-8H3,(H,55,65)(H,57,64)(H,58,67)(H,52,53,56)/t28-,34+,35-,45+/m0/s1","WDBUEMWHXKHQNB-AURZXHAXSA-N"
"2879","P21802","FGFR2","VHL","","NJH-05-166","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","30","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1031.081","1029.38531965","6.71","71","7","14","5","16","206.72","C50H61Cl2N11O7S","InChI=1S/C50H61Cl2N11O7S/c1-29(31-9-11-32(12-10-31)45-30(2)55-28-71-45)56-47(66)36-23-35(64)26-63(36)48(67)46(50(3,4)5)58-41(65)17-18-61-19-21-62(22-20-61)34-15-13-33(14-16-34)57-39-25-40(54-27-53-39)60(6)49(68)59-44-42(51)37(69-7)24-38(70-8)43(44)52/h9-16,24-25,27-29,35-36,46,64H,17-23,26H2,1-8H3,(H,56,66)(H,58,65)(H,59,68)(H,53,54,57)/t29-,35+,36-,46+/m0/s1","ZNPJWQLRJHZTJD-BOWIIDCISA-N"
"2880","P21802","FGFR2","VHL","","NJH-05-132","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","10","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1045.108","1043.40096972","7.07","72","7","14","5","17","206.72","C51H63Cl2N11O7S","InChI=1S/C51H63Cl2N11O7S/c1-30(32-11-13-33(14-12-32)46-31(2)56-29-72-46)57-48(67)37-24-36(65)27-64(37)49(68)47(51(3,4)5)59-42(66)10-9-19-62-20-22-63(23-21-62)35-17-15-34(16-18-35)58-40-26-41(55-28-54-40)61(6)50(69)60-45-43(52)38(70-7)25-39(71-8)44(45)53/h11-18,25-26,28-30,36-37,47,65H,9-10,19-24,27H2,1-8H3,(H,57,67)(H,59,66)(H,60,69)(H,54,55,58)/t30-,36+,37-,47+/m0/s1","RXLNCCJOUYWTSY-XRVDDDQASA-N"
"2881","P21802","FGFR2","VHL","","NJH-05-123","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","16","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1073.162","1071.43226984","7.78","74","7","14","5","19","206.72","C53H67Cl2N11O7S","InChI=1S/C53H67Cl2N11O7S/c1-32(34-13-15-35(16-14-34)48-33(2)58-31-74-48)59-50(69)39-26-38(67)29-66(39)51(70)49(53(3,4)5)61-44(68)12-10-9-11-21-64-22-24-65(25-23-64)37-19-17-36(18-20-37)60-42-28-43(57-30-56-42)63(6)52(71)62-47-45(54)40(72-7)27-41(73-8)46(47)55/h13-20,27-28,30-32,38-39,49,67H,9-12,21-26,29H2,1-8H3,(H,59,69)(H,61,68)(H,62,71)(H,56,57,60)/t32-,38+,39-,49+/m0/s1","NQDPHUVGEBTZGP-WYAMOQRKSA-N"
"2882","P21802","FGFR2","VHL","","NJH-05-043","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","30","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1088.133","1086.40678337","6.05","75","7","15","6","18","235.82","C52H64Cl2N12O8S","InChI=1S/C52H64Cl2N12O8S/c1-30(32-9-11-33(12-10-32)47-31(2)58-29-75-47)59-49(70)37-23-36(67)26-66(37)50(71)48(52(3,4)5)61-42(68)17-18-55-43(69)27-64-19-21-65(22-20-64)35-15-13-34(14-16-35)60-40-25-41(57-28-56-40)63(6)51(72)62-46-44(53)38(73-7)24-39(74-8)45(46)54/h9-16,24-25,28-30,36-37,48,67H,17-23,26-27H2,1-8H3,(H,55,69)(H,59,70)(H,61,68)(H,62,72)(H,56,57,60)/t30-,36+,37-,48+/m0/s1","JTSBMXASQWEDHX-PRWMCYMISA-N"
"2883","P21802","FGFR2","VHL","","NJH-05-044","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(C(=O)NCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","33","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1118.159","1116.41734805","5.85","77","7","15","6","19","245.05","C53H66Cl2N12O9S","InChI=1S/C53H66Cl2N12O9S/c1-31(33-9-11-34(12-10-33)47-32(2)59-30-77-47)60-49(70)38-25-37(68)28-67(38)50(71)48(53(3,4)5)62-43(69)17-23-76-24-18-56-51(72)66-21-19-65(20-22-66)36-15-13-35(14-16-36)61-41-27-42(58-29-57-41)64(6)52(73)63-46-44(54)39(74-7)26-40(75-8)45(46)55/h9-16,26-27,29-31,37-38,48,68H,17-25,28H2,1-8H3,(H,56,72)(H,60,70)(H,62,69)(H,63,73)(H,57,58,61)/t31-,37+,38-,48+/m0/s1","IBBCKHDOUXMNDD-ATOBMBAHSA-N"
"2884","P21802","FGFR2","VHL","","DGY-11-123","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCCCCOC5=CC(C6=C(C)N=CS6)=CC=C5[C@H](C)NC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@@H](NC(C)=O)C(C)(C)C)CC4)C=C3)=NC=N2)=C1Cl","","","","","","59","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1160.24","1158.46429824","7.16","80","7","16","6","22","245.05","C56H72Cl2N12O9S","InChI=1S/C56H72Cl2N12O9S/c1-33(63-53(74)41-26-39(72)29-70(41)54(75)52(56(4,5)6)64-35(3)71)40-18-13-36(51-34(2)62-32-80-51)25-42(40)79-24-12-10-11-19-59-47(73)30-68-20-22-69(23-21-68)38-16-14-37(15-17-38)65-45-28-46(61-31-60-45)67(7)55(76)66-50-48(57)43(77-8)27-44(78-9)49(50)58/h13-18,25,27-28,31-33,39,41,52,72H,10-12,19-24,26,29-30H2,1-9H3,(H,59,73)(H,63,74)(H,64,71)(H,66,76)(H,60,61,65)/t33-,39+,41-,52+/m0/s1","MRMAJCGYNDXOKM-NYCPUKLJSA-N"
"2885","P21802","FGFR2","VHL","","DGY-11-122","COC1=CC(OC)=C(Cl)C(NC(=O)N(C)C2=CC(NC3=CC=C(N4CCN(CC(=O)NCCCCCSC(C)(C)[C@@H](NC(C)=O)C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)CC4)C=C3)=NC=N2)=C1Cl","","","","","","43","IC50 was assessed by Z'-LYTE kinase assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101328","1162.281","1160.42580456","6.73","79","7","16","6","23","235.82","C55H70Cl2N12O8S2","InChI=1S/C55H70Cl2N12O8S2/c1-33(36-12-14-37(15-13-36)50-34(2)61-32-78-50)62-52(73)41-26-40(71)29-69(41)53(74)51(63-35(3)70)55(4,5)79-25-11-9-10-20-58-46(72)30-67-21-23-68(24-22-67)39-18-16-38(17-19-39)64-44-28-45(60-31-59-44)66(6)54(75)65-49-47(56)42(76-7)27-43(77-8)48(49)57/h12-19,27-28,31-33,40-41,51,71H,9-11,20-26,29-30H2,1-8H3,(H,58,72)(H,62,73)(H,63,70)(H,65,75)(H,59,60,64)/t33-,40+,41-,51-/m0/s1","YDWFJDWUHDYBPB-RBDVPONJSA-N"
"2886","P51686","CCR9","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)COCC3=CN(CCOCCOCCOC4=CC(C(=O)C5=CC(Cl)=CC=C5NS(=O)(=O)C5=CC=C(C(C)(C)C)C=C5)=CC=[N+]4[O-])N=N3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","78/151","Ki of the IABS of CCR9 under membrane-based/cell-based conditions was assessed by NanoBRET-based binding assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202116782","1144.771","1143.39608823","5.78","79","7","17","4","25","269.44","C55H66ClN9O12S2","InChI=1S/C55H66ClN9O12S2/c1-35-50(78-34-58-35)37-10-8-36(9-11-37)29-57-52(69)46-28-42(66)31-64(46)53(70)51(55(5,6)7)59-47(67)33-76-32-41-30-63(62-60-41)20-21-74-22-23-75-24-25-77-48-26-38(18-19-65(48)71)49(68)44-27-40(56)14-17-45(44)61-79(72,73)43-15-12-39(13-16-43)54(2,3)4/h8-19,26-27,30,34,42,46,51,61,66H,20-25,28-29,31-33H2,1-7H3,(H,57,69)(H,59,67)/t42-,46+,51-/m1/s1","APZPQGJUPQJGSR-DRHKINIBSA-N"
"2887","Q05397","FAK","VHL","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","125.9 ","","Degradation of FAK in A549 cells after 24 h treatment","","","0.63","IC50 was assessed by FRET","","","","","","","","","","","","","","","316.2","FP","","","","","","","","","","","","","","","5.01","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","1161.359","1160.53404426","6.81","82","7","17","6","27","230.31","C58H75F3N10O10S","InChI=1S/C58H75F3N10O10S/c1-37(39-12-14-40(15-13-39)52-38(2)64-36-82-52)65-55(75)48-31-42(72)34-71(48)56(76)53(57(3,4)5)68-51(73)35-81-29-28-80-27-26-79-25-24-78-23-22-69-18-20-70(21-19-69)41-16-17-46(49(30-41)77-7)67-50-32-47(44(33-63-50)58(59,60)61)66-45-11-9-8-10-43(45)54(74)62-6/h8-17,30,32-33,36-37,42,48,53,72H,18-29,31,34-35H2,1-7H3,(H,62,74)(H,65,75)(H,68,73)(H2,63,66,67)/t37-,42+,48-,53+/m0/s1","FOOHAGZPIHCYKX-ZSFXBAAMSA-N"
"2888","Q05397","FAK","VHL","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCCCCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","20","","Degradation of FAK in A549 cells after 24 h treatment","","","7.94","IC50 was assessed by FRET","","","","","","","","","","","","","","","1995.3","FP","","","","","","","","","","","","","","","2","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","1111.39","1110.57003584","11.09","79","7","13","6","24","193.39","C59H77F3N10O6S","InChI=1S/C59H77F3N10O6S/c1-38(40-21-23-41(24-22-40)53-39(2)65-37-79-53)66-56(76)49-33-43(73)36-72(49)57(77)54(58(3,4)5)69-52(74)20-14-12-10-8-9-11-13-17-27-70-28-30-71(31-29-70)42-25-26-47(50(32-42)78-7)68-51-34-48(45(35-64-51)59(60,61)62)67-46-19-16-15-18-44(46)55(75)63-6/h15-16,18-19,21-26,32,34-35,37-38,43,49,54,73H,8-14,17,20,27-31,33,36H2,1-7H3,(H,63,75)(H,66,76)(H,69,74)(H2,64,67,68)/t38-,43+,49-,54+/m0/s1","LCSUSCWWBGDOAP-JJVMVOSYSA-N"
"2889","Q05397","FAK","VHL","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","158.5 ","","Degradation of FAK in A549 cells after 24 h treatment","","","1","IC50 was assessed by FRET","","","","","","","","","","","","","","","501.2","FP","","","","","","","","","","","","","","","7.94","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","1073.253","1072.48161476","7.11","76","7","15","6","21","211.85","C54H67F3N10O8S","InChI=1S/C54H67F3N10O8S/c1-33(35-12-14-36(15-13-35)48-34(2)60-32-76-48)61-51(71)44-27-38(68)30-67(44)52(72)49(53(3,4)5)64-47(69)31-75-25-24-74-23-22-65-18-20-66(21-19-65)37-16-17-42(45(26-37)73-7)63-46-28-43(40(29-59-46)54(55,56)57)62-41-11-9-8-10-39(41)50(70)58-6/h8-17,26,28-29,32-33,38,44,49,68H,18-25,27,30-31H2,1-7H3,(H,58,70)(H,61,71)(H,64,69)(H2,59,62,63)/t33-,38+,44-,49+/m0/s1","RDCVMTUYWQXPEC-FSHOLZCKSA-N"
"2890","Q05397","FAK","VHL","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","31.6 ","","Degradation of FAK in A549 cells after 24 h treatment","","","1","IC50 was assessed by FRET","","","","","","","","","","","","","","","794.3","FP","","","","","","","","","","","","","","","6.31","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","1029.2","1028.45540002","7.26","73","7","14","6","18","202.62","C52H63F3N10O7S","InChI=1S/C52H63F3N10O7S/c1-31(33-12-14-34(15-13-33)46-32(2)58-30-73-46)59-49(69)42-25-36(66)28-65(42)50(70)47(51(3,4)5)62-45(67)29-72-23-22-63-18-20-64(21-19-63)35-16-17-40(43(24-35)71-7)61-44-26-41(38(27-57-44)52(53,54)55)60-39-11-9-8-10-37(39)48(68)56-6/h8-17,24,26-27,30-31,36,42,47,66H,18-23,25,28-29H2,1-7H3,(H,56,68)(H,59,69)(H,62,67)(H2,57,60,61)/t31-,36+,42-,47+/m0/s1","SLSLLSIRBMAERC-MGVZSLQJSA-N"
"2891","Q05397","FAK","VHL","","","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","39.8 ","","Degradation of FAK in A549 cells after 24 h treatment","","","1.26","IC50 was assessed by FRET","","","","","","","","","","","","","","","1258.9","FP","","","","","","","","","","","","","","","10","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","999.174","998.444835332","7.31","71","7","13","6","16","193.39","C51H61F3N10O6S","InChI=1S/C51H61F3N10O6S/c1-30(32-12-14-33(15-13-32)45-31(2)57-29-71-45)58-48(68)41-25-35(65)28-64(41)49(69)46(50(3,4)5)61-44(66)18-19-62-20-22-63(23-21-62)34-16-17-39(42(24-34)70-7)60-43-26-40(37(27-56-43)51(52,53)54)59-38-11-9-8-10-36(38)47(67)55-6/h8-17,24,26-27,29-30,35,41,46,65H,18-23,25,28H2,1-7H3,(H,55,67)(H,58,68)(H,61,66)(H2,56,59,60)/t30-,35+,41-,46+/m0/s1","ASRIXACKPXMNKY-FCFVTTBASA-N"
"2892","Q05397","FAK","VHL","7PI4","GSK215","CNC(=O)C1=CC=CC=C1NC1=CC(NC2=CC=C(N3CCN(CC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)N[C@@H](C)C4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C=C2OC)=NC=C1C(F)(F)F","4","","Degradation of FAK in A549 cells after 24 h treatment","","","1.58","IC50 was assessed by FRET","","","","","","","","","","","","","","","1000","FP","","","","","","","","","","","","","","","1.26","IC50 between VHL and the complex of protac and FAK was tested by FRET","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202109237","985.147","984.429185268","7.4","70","7","13","6","15","193.39","C50H59F3N10O6S","InChI=1S/C50H59F3N10O6S/c1-29(31-12-14-32(15-13-31)44-30(2)56-28-70-44)57-47(67)40-23-34(64)26-63(40)48(68)45(49(3,4)5)60-43(65)27-61-18-20-62(21-19-61)33-16-17-38(41(22-33)69-7)59-42-24-39(36(25-55-42)50(51,52)53)58-37-11-9-8-10-35(37)46(66)54-6/h8-17,22,24-25,28-29,34,40,45,64H,18-21,23,26-27H2,1-7H3,(H,54,66)(H,57,67)(H,60,65)(H2,55,58,59)/t29-,34+,40-,45+/m0/s1","ZGSWGXNEXAXEGV-XFCHVEHOSA-N"
"2893","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","23.7","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","17","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.222/710.45","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","17","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","866.361","865.2521413","2.45","61","8","15","3","14","224.76","C41H40ClN11O7S","InChI=1S/C41H40ClN11O7S/c1-21-22(2)61-41-34(21)36(24-9-11-25(42)12-10-24)45-28(37-49-47-23(3)52(37)41)17-32(55)44-18-26-19-51(50-48-26)16-5-4-15-43-33(56)20-60-30-8-6-7-27-35(30)40(59)53(39(27)58)29-13-14-31(54)46-38(29)57/h6-12,19,28-29H,4-5,13-18,20H2,1-3H3,(H,43,56)(H,44,55)(H,46,54,57)/t28-,29?/m0/s1","DCJYEKOZHBUGTG-XLTVJXRZSA-N"
"2893","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","10.6","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","17","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.222/710.45","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","866.361","865.2521413","2.45","61","8","15","3","14","224.76","C41H40ClN11O7S","InChI=1S/C41H40ClN11O7S/c1-21-22(2)61-41-34(21)36(24-9-11-25(42)12-10-24)45-28(37-49-47-23(3)52(37)41)17-32(55)44-18-26-19-51(50-48-26)16-5-4-15-43-33(56)20-60-30-8-6-7-27-35(30)40(59)53(39(27)58)29-13-14-31(54)46-38(29)57/h6-12,19,28-29H,4-5,13-18,20H2,1-3H3,(H,43,56)(H,44,55)(H,46,54,57)/t28-,29?/m0/s1","DCJYEKOZHBUGTG-XLTVJXRZSA-N"
"2894","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","1.7","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","4","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.208/105","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","2.2","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","865.377","864.268125712","3.02","61","8","15","4","14","227.56","C41H41ClN12O6S","InChI=1S/C41H41ClN12O6S/c1-21-22(2)61-41-34(21)36(24-9-11-25(42)12-10-24)46-29(37-50-48-23(3)53(37)41)17-32(56)45-18-26-20-52(51-49-26)16-5-4-15-43-33(57)19-44-28-8-6-7-27-35(28)40(60)54(39(27)59)30-13-14-31(55)47-38(30)58/h6-12,20,29-30,44H,4-5,13-19H2,1-3H3,(H,43,57)(H,45,56)(H,47,55,58)/t29-,30?/m0/s1","RXKCXGDDGPGXLS-UFXYQILXSA-N"
"2894","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","0.2","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","4","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.208/105","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","865.377","864.268125712","3.02","61","8","15","4","14","227.56","C41H41ClN12O6S","InChI=1S/C41H41ClN12O6S/c1-21-22(2)61-41-34(21)36(24-9-11-25(42)12-10-24)46-29(37-50-48-23(3)53(37)41)17-32(56)45-18-26-20-52(51-49-26)16-5-4-15-43-33(57)19-44-28-8-6-7-27-35(28)40(60)54(39(27)59)30-13-14-31(55)47-38(30)58/h6-12,20,29-30,44H,4-5,13-19H2,1-3H3,(H,43,57)(H,45,56)(H,47,55,58)/t29-,30?/m0/s1","RXKCXGDDGPGXLS-UFXYQILXSA-N"
"2895","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)COC3=CC=C(C4CCC(=O)NC4=O)C=C3)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","1046","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","36","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.199/334.55","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","21.4","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","797.342","796.267063092","3.34","56","7","13","3","14","187.38","C39H41ClN10O5S","InChI=1S/C39H41ClN10O5S/c1-22-23(2)56-39-35(22)36(26-6-10-27(40)11-7-26)43-31(37-47-45-24(3)50(37)39)18-33(52)42-19-28-20-49(48-46-28)17-5-4-16-41-34(53)21-55-29-12-8-25(9-13-29)30-14-15-32(51)44-38(30)54/h6-13,20,30-31H,4-5,14-19,21H2,1-3H3,(H,41,53)(H,42,52)(H,44,51,54)/t30?,31-/m0/s1","IWOYRWZKNMTQQZ-FLDQDSGZSA-N"
"2895","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)COC3=CC=C(C4CCC(=O)NC4=O)C=C3)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","213.1","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","36","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.199/334.55","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","797.342","796.267063092","3.34","56","7","13","3","14","187.38","C39H41ClN10O5S","InChI=1S/C39H41ClN10O5S/c1-22-23(2)56-39-35(22)36(26-6-10-27(40)11-7-26)43-31(37-47-45-24(3)50(37)39)18-33(52)42-19-28-20-49(48-46-28)17-5-4-16-41-34(53)21-55-29-12-8-25(9-13-29)30-14-15-32(51)44-38(30)54/h6-13,20,30-31H,4-5,14-19,21H2,1-3H3,(H,41,53)(H,42,52)(H,44,51,54)/t30?,31-/m0/s1","IWOYRWZKNMTQQZ-FLDQDSGZSA-N"
"2896","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)CNC3=CC=C(C4CCC(=O)NC4=O)C=C3)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","47.9","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","92","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.133/102.78","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","3.2","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","796.358","795.283047504","3.36","56","7","13","4","14","190.18","C39H42ClN11O4S","InChI=1S/C39H42ClN11O4S/c1-22-23(2)56-39-35(22)36(26-6-10-27(40)11-7-26)44-31(37-48-46-24(3)51(37)39)18-33(53)43-19-29-21-50(49-47-29)17-5-4-16-41-34(54)20-42-28-12-8-25(9-13-28)30-14-15-32(52)45-38(30)55/h6-13,21,30-31,42H,4-5,14-20H2,1-3H3,(H,41,54)(H,43,53)(H,45,52,55)/t30?,31-/m0/s1","QRWLGRXLCZHZNC-FLDQDSGZSA-N"
"2896","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCC1=CN(CCCCNC(=O)CNC3=CC=C(C4CCC(=O)NC4=O)C=C3)N=N1)N=C2C1=CC=C(Cl)C=C1","","","","","","10.6","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","92","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.133/102.78","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","796.358","795.283047504","3.36","56","7","13","4","14","190.18","C39H42ClN11O4S","InChI=1S/C39H42ClN11O4S/c1-22-23(2)56-39-35(22)36(26-6-10-27(40)11-7-26)44-31(37-48-46-24(3)51(37)39)18-33(53)43-19-29-21-50(49-47-29)17-5-4-16-41-34(54)20-42-28-12-8-25(9-13-28)30-14-15-32(52)45-38(30)55/h6-13,21,30-31,42H,4-5,14-20H2,1-3H3,(H,41,54)(H,43,53)(H,45,52,55)/t30?,31-/m0/s1","QRWLGRXLCZHZNC-FLDQDSGZSA-N"
"2897","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=C(C3CCC(=O)NC3=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","8159","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","58","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.06/13.22","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","16.6","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","716.264","715.234365996","4.11","50","6","10","3","12","156.67","C36H38ClN7O5S","InChI=1S/C36H38ClN7O5S/c1-20-21(2)50-36-32(20)33(24-6-10-25(37)11-7-24)40-28(34-43-42-22(3)44(34)36)18-30(46)38-16-4-5-17-39-31(47)19-49-26-12-8-23(9-13-26)27-14-15-29(45)41-35(27)48/h6-13,27-28H,4-5,14-19H2,1-3H3,(H,38,46)(H,39,47)(H,41,45,48)/t27?,28-/m0/s1","GBDCMEGOGDECAV-CPRJBALCSA-N"
"2897","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=C(C3CCC(=O)NC3=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","167.3","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","58","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.06/13.22","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","716.264","715.234365996","4.11","50","6","10","3","12","156.67","C36H38ClN7O5S","InChI=1S/C36H38ClN7O5S/c1-20-21(2)50-36-32(20)33(24-6-10-25(37)11-7-24)40-28(34-43-42-22(3)44(34)36)18-30(46)38-16-4-5-17-39-31(47)19-49-26-12-8-23(9-13-26)27-14-15-29(45)41-35(27)48/h6-13,27-28H,4-5,14-19H2,1-3H3,(H,38,46)(H,39,47)(H,41,45,48)/t27?,28-/m0/s1","GBDCMEGOGDECAV-CPRJBALCSA-N"
"2898","O60885","BRD4","CRBN","","SJ995973","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)COC1=CC=C(C3CCC(=O)NC3=O)C=C1)N=C2C1=CC=C(Cl)C=C1","0.87/0.16","","Degradation of BRD4 in MV4-11 cells after 12/24 h treatment","","","3531","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","17","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.003","Inhibit proliferation of MV4-11 cells","","","","","","","","","","","14.3","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","730.291","729.25001606","4.47","51","6","10","3","13","156.67","C37H40ClN7O5S","InChI=1S/C37H40ClN7O5S/c1-21-22(2)51-37-33(21)34(25-7-11-26(38)12-8-25)41-29(35-44-43-23(3)45(35)37)19-31(47)39-17-5-4-6-18-40-32(48)20-50-27-13-9-24(10-14-27)28-15-16-30(46)42-36(28)49/h7-14,28-29H,4-6,15-20H2,1-3H3,(H,39,47)(H,40,48)(H,42,46,49)/t28?,29-/m0/s1","VVRONDSUSMJAEI-XIJSCUBXSA-N"
"2898","O60885","BRD4","CRBN","","SJ995973","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)COC1=CC=C(C3CCC(=O)NC3=O)C=C1)N=C2C1=CC=C(Cl)C=C1","24","","Degradation of BRD4 in HD-MB03 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.83","Inhibit proliferation of HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","730.291","729.25001606","4.47","51","6","10","3","13","156.67","C37H40ClN7O5S","InChI=1S/C37H40ClN7O5S/c1-21-22(2)51-37-33(21)34(25-7-11-26(38)12-8-25)41-29(35-44-43-23(3)45(35)37)19-31(47)39-17-5-4-6-18-40-32(48)20-50-27-13-9-24(10-14-27)28-15-16-30(46)42-36(28)49/h7-14,28-29H,4-6,15-20H2,1-3H3,(H,39,47)(H,40,48)(H,42,46,49)/t28?,29-/m0/s1","VVRONDSUSMJAEI-XIJSCUBXSA-N"
"2898","P25440","BRD2","CRBN","","SJ995973","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)COC1=CC=C(C3CCC(=O)NC3=O)C=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","485.1","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","17","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.003/1.83","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","730.291","729.25001606","4.47","51","6","10","3","13","156.67","C37H40ClN7O5S","InChI=1S/C37H40ClN7O5S/c1-21-22(2)51-37-33(21)34(25-7-11-26(38)12-8-25)41-29(35-44-43-23(3)45(35)37)19-31(47)39-17-5-4-6-18-40-32(48)20-50-27-13-9-24(10-14-27)28-15-16-30(46)42-36(28)49/h7-14,28-29H,4-6,15-20H2,1-3H3,(H,39,47)(H,40,48)(H,42,46,49)/t28?,29-/m0/s1","VVRONDSUSMJAEI-XIJSCUBXSA-N"
"2899","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC(C3CCC(=O)NC3=O)=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","2729","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","137","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20.076/379.65","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","1","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","716.264","715.234365996","4.11","50","6","10","3","12","156.67","C36H38ClN7O5S","InChI=1S/C36H38ClN7O5S/c1-20-21(2)50-36-32(20)33(23-9-11-25(37)12-10-23)40-28(34-43-42-22(3)44(34)36)18-30(46)38-15-4-5-16-39-31(47)19-49-26-8-6-7-24(17-26)27-13-14-29(45)41-35(27)48/h6-12,17,27-28H,4-5,13-16,18-19H2,1-3H3,(H,38,46)(H,39,47)(H,41,45,48)/t27?,28-/m0/s1","QGEJTBUIXFGTCP-CPRJBALCSA-N"
"2899","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCNC(=O)COC1=CC=CC(C3CCC(=O)NC3=O)=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","800.2","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","137","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","20.076/379.65","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","716.264","715.234365996","4.11","50","6","10","3","12","156.67","C36H38ClN7O5S","InChI=1S/C36H38ClN7O5S/c1-20-21(2)50-36-32(20)33(23-9-11-25(37)12-10-23)40-28(34-43-42-22(3)44(34)36)18-30(46)38-15-4-5-16-39-31(47)19-49-26-8-6-7-24(17-26)27-13-14-29(45)41-35(27)48/h6-12,17,27-28H,4-5,13-16,18-19H2,1-3H3,(H,38,46)(H,39,47)(H,41,45,48)/t27?,28-/m0/s1","QGEJTBUIXFGTCP-CPRJBALCSA-N"
"2900","O60885","BRD4","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)COC1=CC=CC(C3CCC(=O)NC3=O)=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","2082","IC50 of BRD4 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","149","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.147/64.85","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","9.7","Compounds were administered at 10000 nM and incubated for 2 h","","","10.1002/anie.202108848","730.291","729.25001606","4.47","51","6","10","3","13","156.67","C37H40ClN7O5S","InChI=1S/C37H40ClN7O5S/c1-21-22(2)51-37-33(21)34(24-10-12-26(38)13-11-24)41-29(35-44-43-23(3)45(35)37)19-31(47)39-16-5-4-6-17-40-32(48)20-50-27-9-7-8-25(18-27)28-14-15-30(46)42-36(28)49/h7-13,18,28-29H,4-6,14-17,19-20H2,1-3H3,(H,39,47)(H,40,48)(H,42,46,49)/t28?,29-/m0/s1","MMTCVCBFVYDBKE-XIJSCUBXSA-N"
"2900","P25440","BRD2","CRBN","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)COC1=CC=CC(C3CCC(=O)NC3=O)=C1)N=C2C1=CC=C(Cl)C=C1","","","","","","395.2","IC50 of BRD2 BD2 was assessed by TR-FRET","","","","","","","","","","","","","","","149","FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1.147/64.85","Inhibit proliferation of MV4-11/HD-MB03 cells","","","","","","","","","","","","","","","10.1002/anie.202108848","730.291","729.25001606","4.47","51","6","10","3","13","156.67","C37H40ClN7O5S","InChI=1S/C37H40ClN7O5S/c1-21-22(2)51-37-33(21)34(24-10-12-26(38)13-11-24)41-29(35-44-43-23(3)45(35)37)19-31(47)39-16-5-4-6-17-40-32(48)20-50-27-9-7-8-25(18-27)28-14-15-30(46)42-36(28)49/h7-13,18,28-29H,4-6,14-17,19-20H2,1-3H3,(H,39,47)(H,40,48)(H,42,46,49)/t28?,29-/m0/s1","MMTCVCBFVYDBKE-XIJSCUBXSA-N"
"2901","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCC4=CN(CC(=O)NC5=CC=C(C6=CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/16","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","175","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","647.604","647.17646076","2.23","48","7","12","4","8","205.83","C33H25N7O8","InChI=1S/C33H25N7O8/c41-21-9-6-18-12-23(33(47)48-26(18)13-21)17-4-7-19(8-5-17)35-28(43)16-39-15-20(37-38-39)14-34-24-3-1-2-22-29(24)32(46)40(31(22)45)25-10-11-27(42)36-30(25)44/h1-9,12-13,15,25,34,41H,10-11,14,16H2,(H,35,43)(H,36,42,44)","KMBWGAMCGFNXMV-UHFFFAOYSA-N"
"2902","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCC4=CN(CC(=O)NC5=CC=C(C6=CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/31","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","192","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","689.641","689.187025444","1.82","51","7","12","4","9","222.9","C35H27N7O9","InChI=1S/C35H27N7O9/c43-22-10-6-19-14-24(35(50)51-27(19)15-22)18-4-7-20(8-5-18)36-30(46)17-41-16-21(39-40-41)9-12-28(44)37-25-3-1-2-23-31(25)34(49)42(33(23)48)26-11-13-29(45)38-32(26)47/h1-8,10,14-16,26,43H,9,11-13,17H2,(H,36,46)(H,37,44)(H,38,45,47)","IEUQMEXKEZSPAJ-UHFFFAOYSA-N"
"2903","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCC4=CN(CC(=O)NC5=CC=C(C6=CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/22","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","121","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","703.668","703.202675508","2.17","52","7","12","4","10","222.9","C36H29N7O9","InChI=1S/C36H29N7O9/c44-23-12-9-20-15-25(36(51)52-28(20)16-23)19-7-10-21(11-8-19)37-31(47)18-42-17-22(40-41-42)3-1-6-29(45)38-26-5-2-4-24-32(26)35(50)43(34(24)49)27-13-14-30(46)39-33(27)48/h2,4-5,7-12,15-17,27,44H,1,3,6,13-14,18H2,(H,37,47)(H,38,45)(H,39,46,48)","PUYCLWKAXZSAKE-UHFFFAOYSA-N"
"2904","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCC4=CN(CC(=O)NC5=CC=C(C6=CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/50","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","155","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","717.695","717.218325572","2.53","53","7","12","4","11","222.9","C37H31N7O9","InChI=1S/C37H31N7O9/c45-24-13-10-21-16-26(37(52)53-29(21)17-24)20-8-11-22(12-9-20)38-32(48)19-43-18-23(41-42-43)4-1-2-7-30(46)39-27-6-3-5-25-33(27)36(51)44(35(25)50)28-14-15-31(47)40-34(28)49/h3,5-6,8-13,16-18,28,45H,1-2,4,7,14-15,19H2,(H,38,48)(H,39,46)(H,40,47,49)","AQABLWIOALJCAJ-UHFFFAOYSA-N"
"2905","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCCC4=CN(CCC(=O)NC5=CC=C(C6=CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/58","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","597","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","731.722","731.233975636","2.27","54","7","12","4","12","222.9","C38H33N7O9","InChI=1S/C38H33N7O9/c46-25-13-10-22-18-27(38(53)54-30(22)19-25)21-8-11-23(12-9-21)39-33(49)16-17-44-20-24(42-43-44)4-1-2-7-31(47)40-28-6-3-5-26-34(28)37(52)45(36(26)51)29-14-15-32(48)41-35(29)50/h3,5-6,8-13,18-20,29,46H,1-2,4,7,14-17H2,(H,39,49)(H,40,47)(H,41,48,50)","KSBWNBZEAMKBAF-UHFFFAOYSA-N"
"2906","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CC4=CC=C(N5C=C(CCCC(=O)NC6=CC=C(C7=CC8=CC=C(O)C=C8OC7=O)C=C6)N=N5)C=C4)=C3C2=O)C(=O)N1","","","","0/0","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","999","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","779.766","779.233975636","3.6","58","8","12","4","11","222.9","C42H33N7O9","InChI=1S/C42H33N7O9/c50-29-16-11-25-20-31(42(57)58-34(25)21-29)24-9-12-26(13-10-24)43-35(51)6-1-3-27-22-48(47-46-27)28-14-7-23(8-15-28)19-37(53)44-32-5-2-4-30-38(32)41(56)49(40(30)55)33-17-18-36(52)45-39(33)54/h2,4-5,7-16,20-22,33,50H,1,3,6,17-19H2,(H,43,51)(H,44,53)(H,45,52,54)","PJJPCIPYTHBDMV-UHFFFAOYSA-N"
"2907","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCC(=O)NC4=CC=C(N5CC6=CC=C(O)C=C6OC5=O)C=C4)=C3C2=O)C(=O)N1","","","","0/61","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","55","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","611.611","611.201612888","2.72","45","6","9","4","9","174.45","C32H29N5O8","InChI=1S/C32H29N5O8/c38-21-12-7-18-17-36(32(44)45-25(18)16-21)20-10-8-19(9-11-20)34-26(39)6-1-2-15-33-23-5-3-4-22-28(23)31(43)37(30(22)42)24-13-14-27(40)35-29(24)41/h3-5,7-12,16,24,33,38H,1-2,6,13-15,17H2,(H,34,39)(H,35,40,41)","KLHUIDHIWSXXQJ-UHFFFAOYSA-N"
"2908","P14174","MIF","CRBN","","","O=C(CCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCC1=CC=C(N2CC3=CC=C(O)C=C3OC2=O)C=C1","","","","21/51","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","86","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","625.638","625.217262952","2.66","46","6","9","4","10","174.45","C33H31N5O8","InChI=1S/C33H31N5O8/c39-22-12-9-20-18-37(33(45)46-26(20)16-22)21-10-7-19(8-11-21)17-35-27(40)6-1-2-15-34-24-5-3-4-23-29(24)32(44)38(31(23)43)25-13-14-28(41)36-30(25)42/h3-5,7-12,16,25,34,39H,1-2,6,13-15,17-18H2,(H,35,40)(H,36,41,42)","OFSICBPDCRHEFY-UHFFFAOYSA-N"
"2909","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCC(=O)NC4=CC=C(N5CC6=CC=C(O)C=C6OC5=O)C=C4)=C3C2=O)C(=O)N1","1500","","Degradation of MIF in A549 cells after 12 h treatment","","","","","","","","","51","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","639.665","639.232913016","3.62","47","6","9","4","11","174.45","C34H33N5O8","InChI=1S/C34H33N5O8/c40-23-14-9-20-19-38(34(46)47-27(20)18-23)22-12-10-21(11-13-22)36-28(41)8-3-1-2-4-17-35-25-7-5-6-24-30(25)33(45)39(32(24)44)26-15-16-29(42)37-31(26)43/h5-7,9-14,18,26,35,40H,1-4,8,15-17,19H2,(H,36,41)(H,37,42,43)","NQPSGZCAWSOJJH-UHFFFAOYSA-N"
"2910","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCC4=CN(CCC(=O)NC5=CC=C(N6CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","55/61","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","98","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","664.635","664.203009856","1.24","49","7","12","4","9","205.16","C33H28N8O8","InChI=1S/C33H28N8O8/c42-22-9-4-18-16-40(33(48)49-26(18)14-22)21-7-5-19(6-8-21)35-28(44)12-13-39-17-20(37-38-39)15-34-24-3-1-2-23-29(24)32(47)41(31(23)46)25-10-11-27(43)36-30(25)45/h1-9,14,17,25,34,42H,10-13,15-16H2,(H,35,44)(H,36,43,45)","OYSUXNRBBHEVNQ-UHFFFAOYSA-N"
"2911","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NC(=O)CCCC4=CN(CCC(=O)NC5=CC=C(N6CC7=CC=C(O)C=C7OC6=O)C=C5)N=N4)=C3C2=O)C(=O)N1","","","","0/40","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","95","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","720.699","720.229224604","1.18","53","7","12","4","11","222.23","C36H32N8O9","InChI=1S/C36H32N8O9/c45-24-12-7-20-18-43(36(52)53-28(20)17-24)23-10-8-21(9-11-23)37-31(48)15-16-42-19-22(40-41-42)3-1-6-29(46)38-26-5-2-4-25-32(26)35(51)44(34(25)50)27-13-14-30(47)39-33(27)49/h2,4-5,7-12,17,19,27,45H,1,3,6,13-16,18H2,(H,37,48)(H,38,46)(H,39,47,49)","DBUPAZUPJOJWJN-UHFFFAOYSA-N"
"2912","P14174","MIF","CRBN","","","O=C(CC1=CC=C(N2CC3=CC=C(O)C=C3OC2=O)C=C1)NCC1=CN(C2=CC=C(CC(=O)NC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2)N=N1","","","","0/38","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","92","Ki was assessed by MIF catalyzed 4-HPP tautomerization assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","768.743","768.229224604","2.15","57","8","12","4","10","222.23","C40H32N8O9","InChI=1S/C40H32N8O9/c49-28-13-8-24-20-46(40(56)57-32(24)18-28)26-9-4-22(5-10-26)16-34(51)41-19-25-21-47(45-44-25)27-11-6-23(7-12-27)17-35(52)42-30-3-1-2-29-36(30)39(55)48(38(29)54)31-14-15-33(50)43-37(31)53/h1-13,18,21,31,49H,14-17,19-20H2,(H,41,51)(H,42,52)(H,43,50,53)","MWRAVXWSTHBDDB-UHFFFAOYSA-N"
"2913","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCC(=O)NC4=CC=C(N5CC6=CC=C(O)C=C6OC5=O)C=C4)=C3C2=O)C(=O)N1","100","90-95","Degradation of MIF in A549 cells after 12 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","653.692","653.24856308","4.16","48","6","9","4","12","174.45","C35H35N5O8","InChI=1S/C35H35N5O8/c41-24-15-10-21-20-39(35(47)48-28(21)19-24)23-13-11-22(12-14-23)37-29(42)9-4-2-1-3-5-18-36-26-8-6-7-25-31(26)34(46)40(33(25)45)27-16-17-30(43)38-32(27)44/h6-8,10-15,19,27,36,41H,1-5,9,16-18,20H2,(H,37,42)(H,38,43,44)","HAHDZDUOFHMMEA-UHFFFAOYSA-N"
"2914","P14174","MIF","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCCCCC(=O)NC4=CC=C(N5CC6=CC=C(O)C=C6OC5=O)C=C4)=C3C2=O)C(=O)N1","","","","51/64","% MIF degradation in A549 cells after 12 h treatment at 2000/20000 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/anie.202101864","681.746","681.279863208","5.24","50","6","9","4","14","174.45","C37H39N5O8","InChI=1S/C37H39N5O8/c43-26-17-12-23-22-41(37(49)50-30(23)21-26)25-15-13-24(14-16-25)39-31(44)11-6-4-2-1-3-5-7-20-38-28-10-8-9-27-33(28)36(48)42(35(27)47)29-18-19-32(45)40-34(29)46/h8-10,12-17,21,29,38,43H,1-7,11,18-20,22H2,(H,39,44)(H,40,45,46)","CIGMKYGNUVZASF-UHFFFAOYSA-N"
"2915","P42336","PI3Kalpha","VHL","","","COC1=NC=C(C2=CN3C(C4=NN=C(C5=CC=CC=C5C(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCC5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)O4)=CN=C3C=C2)C=C1NS(=O)(=O)C1=CC=C(F)C=C1F","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmc.2022.116707","1017.11","1016.29095687","6.58","72","9","15","4","14","236.14","C50H46F2N10O8S2","InChI=1S/C50H46F2N10O8S2/c1-27-42(71-26-56-27)29-12-10-28(11-13-29)21-54-45(65)38-20-33(63)25-62(38)49(66)43(50(2,3)4)57-44(64)34-8-6-7-9-35(34)46-58-59-48(70-46)39-23-53-41-17-14-30(24-61(39)41)31-18-37(47(69-5)55-22-31)60-72(67,68)40-16-15-32(51)19-36(40)52/h6-19,22-24,26,33,38,43,60,63H,20-21,25H2,1-5H3,(H,54,65)(H,57,64)/t33-,38+,43-/m1/s1","NDHMQNOTIVNSLN-TZSMONEZSA-N"
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"2928","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","1.34","58","8","14","5","10","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-39(2,3)29-15-30(48-58-29)45-38(57)43-22-9-7-21(8-10-22)25-18-50(35-33(25)34(40)41-20-42-35)16-23-17-51(49-47-23)14-13-32(54)44-27-6-4-5-24-26(27)19-52(37(24)56)28-11-12-31(53)46-36(28)55/h4-10,15,17-18,20,28H,11-14,16,19H2,1-3H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","MRLORPAGZACFBP-UHFFFAOYSA-N"
"2928","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","1.34","58","8","14","5","10","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-39(2,3)29-15-30(48-58-29)45-38(57)43-22-9-7-21(8-10-22)25-18-50(35-33(25)34(40)41-20-42-35)16-23-17-51(49-47-23)14-13-32(54)44-27-6-4-5-24-26(27)19-52(37(24)56)28-11-12-31(53)46-36(28)55/h4-10,15,17-18,20,28H,11-14,16,19H2,1-3H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","MRLORPAGZACFBP-UHFFFAOYSA-N"
"2928","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","1.34","58","8","14","5","10","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-39(2,3)29-15-30(48-58-29)45-38(57)43-22-9-7-21(8-10-22)25-18-50(35-33(25)34(40)41-20-42-35)16-23-17-51(49-47-23)14-13-32(54)44-27-6-4-5-24-26(27)19-52(37(24)56)28-11-12-31(53)46-36(28)55/h4-10,15,17-18,20,28H,11-14,16,19H2,1-3H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","MRLORPAGZACFBP-UHFFFAOYSA-N"
"2929","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","66.71/110.37","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","1.7","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-19-51(36-34(26)35(41)42-21-43-36)17-24-18-52(50-48-24)15-5-8-32(54)45-28-7-4-6-25-27(28)20-53(38(25)57)29-13-14-33(55)47-37(29)56/h4,6-7,9-12,16,18-19,21,29H,5,8,13-15,17,20H2,1-3H3,(H,45,54)(H2,41,42,43)(H,47,55,56)(H2,44,46,49,58)","RXXFLZDIUKKZGL-UHFFFAOYSA-N"
"2929","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","1.7","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-19-51(36-34(26)35(41)42-21-43-36)17-24-18-52(50-48-24)15-5-8-32(54)45-28-7-4-6-25-27(28)20-53(38(25)57)29-13-14-33(55)47-37(29)56/h4,6-7,9-12,16,18-19,21,29H,5,8,13-15,17,20H2,1-3H3,(H,45,54)(H2,41,42,43)(H,47,55,56)(H2,44,46,49,58)","RXXFLZDIUKKZGL-UHFFFAOYSA-N"
"2929","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","1.7","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-19-51(36-34(26)35(41)42-21-43-36)17-24-18-52(50-48-24)15-5-8-32(54)45-28-7-4-6-25-27(28)20-53(38(25)57)29-13-14-33(55)47-37(29)56/h4,6-7,9-12,16,18-19,21,29H,5,8,13-15,17,20H2,1-3H3,(H,45,54)(H2,41,42,43)(H,47,55,56)(H2,44,46,49,58)","RXXFLZDIUKKZGL-UHFFFAOYSA-N"
"2929","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","1.7","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-19-51(36-34(26)35(41)42-21-43-36)17-24-18-52(50-48-24)15-5-8-32(54)45-28-7-4-6-25-27(28)20-53(38(25)57)29-13-14-33(55)47-37(29)56/h4,6-7,9-12,16,18-19,21,29H,5,8,13-15,17,20H2,1-3H3,(H,45,54)(H2,41,42,43)(H,47,55,56)(H2,44,46,49,58)","RXXFLZDIUKKZGL-UHFFFAOYSA-N"
"2930","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.03/14.26","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.05","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-20-52(37-35(27)36(42)43-22-44-37)18-25-19-53(51-49-25)16-5-4-9-33(55)46-29-8-6-7-26-28(29)21-54(39(26)58)30-14-15-34(56)48-38(30)57/h6-8,10-13,17,19-20,22,30H,4-5,9,14-16,18,21H2,1-3H3,(H,46,55)(H2,42,43,44)(H,48,56,57)(H2,45,47,50,59)","YUSPLSVWUCLTGM-UHFFFAOYSA-N"
"2930","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","64.02","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.05","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-20-52(37-35(27)36(42)43-22-44-37)18-25-19-53(51-49-25)16-5-4-9-33(55)46-29-8-6-7-26-28(29)21-54(39(26)58)30-14-15-34(56)48-38(30)57/h6-8,10-13,17,19-20,22,30H,4-5,9,14-16,18,21H2,1-3H3,(H,46,55)(H2,42,43,44)(H,48,56,57)(H2,45,47,50,59)","YUSPLSVWUCLTGM-UHFFFAOYSA-N"
"2930","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.05","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-20-52(37-35(27)36(42)43-22-44-37)18-25-19-53(51-49-25)16-5-4-9-33(55)46-29-8-6-7-26-28(29)21-54(39(26)58)30-14-15-34(56)48-38(30)57/h6-8,10-13,17,19-20,22,30H,4-5,9,14-16,18,21H2,1-3H3,(H,46,55)(H2,42,43,44)(H,48,56,57)(H2,45,47,50,59)","YUSPLSVWUCLTGM-UHFFFAOYSA-N"
"2930","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.05","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-20-52(37-35(27)36(42)43-22-44-37)18-25-19-53(51-49-25)16-5-4-9-33(55)46-29-8-6-7-26-28(29)21-54(39(26)58)30-14-15-34(56)48-38(30)57/h6-8,10-13,17,19-20,22,30H,4-5,9,14-16,18,21H2,1-3H3,(H,46,55)(H2,42,43,44)(H,48,56,57)(H2,45,47,50,59)","YUSPLSVWUCLTGM-UHFFFAOYSA-N"
"2931","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.03/12.13","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.41","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-18-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)19-26-20-54(52-50-26)17-6-4-5-10-34(56)47-30-9-7-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h7-9,11-14,18,20-21,23,31H,4-6,10,15-17,19,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","JXRMTWOZUDYNBA-UHFFFAOYSA-N"
"2931","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","56.68","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.41","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-18-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)19-26-20-54(52-50-26)17-6-4-5-10-34(56)47-30-9-7-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h7-9,11-14,18,20-21,23,31H,4-6,10,15-17,19,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","JXRMTWOZUDYNBA-UHFFFAOYSA-N"
"2931","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.41","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-18-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)19-26-20-54(52-50-26)17-6-4-5-10-34(56)47-30-9-7-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h7-9,11-14,18,20-21,23,31H,4-6,10,15-17,19,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","JXRMTWOZUDYNBA-UHFFFAOYSA-N"
"2931","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.41","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-18-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)19-26-20-54(52-50-26)17-6-4-5-10-34(56)47-30-9-7-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h7-9,11-14,18,20-21,23,31H,4-6,10,15-17,19,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","JXRMTWOZUDYNBA-UHFFFAOYSA-N"
"2932","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.57/9.85","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","771.799","771.298975904","1.6","57","8","14","5","9","250.18","C38H37N13O6","InChI=1S/C38H37N13O6/c1-38(2,3)28-13-29(47-57-28)44-37(56)42-21-9-7-20(8-10-21)24-16-49(34-32(24)33(39)40-19-41-34)14-22-15-50(48-46-22)18-31(53)43-26-6-4-5-23-25(26)17-51(36(23)55)27-11-12-30(52)45-35(27)54/h4-10,13,15-16,19,27H,11-12,14,17-18H2,1-3H3,(H,43,53)(H2,39,40,41)(H,45,52,54)(H2,42,44,47,56)","LUFIMFUAXRLQRQ-UHFFFAOYSA-N"
"2932","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22.24","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","771.799","771.298975904","1.6","57","8","14","5","9","250.18","C38H37N13O6","InChI=1S/C38H37N13O6/c1-38(2,3)28-13-29(47-57-28)44-37(56)42-21-9-7-20(8-10-21)24-16-49(34-32(24)33(39)40-19-41-34)14-22-15-50(48-46-22)18-31(53)43-26-6-4-5-23-25(26)17-51(36(23)55)27-11-12-30(52)45-35(27)54/h4-10,13,15-16,19,27H,11-12,14,17-18H2,1-3H3,(H,43,53)(H2,39,40,41)(H,45,52,54)(H2,42,44,47,56)","LUFIMFUAXRLQRQ-UHFFFAOYSA-N"
"2932","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","414.7","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","771.799","771.298975904","1.6","57","8","14","5","9","250.18","C38H37N13O6","InChI=1S/C38H37N13O6/c1-38(2,3)28-13-29(47-57-28)44-37(56)42-21-9-7-20(8-10-21)24-16-49(34-32(24)33(39)40-19-41-34)14-22-15-50(48-46-22)18-31(53)43-26-6-4-5-23-25(26)17-51(36(23)55)27-11-12-30(52)45-35(27)54/h4-10,13,15-16,19,27H,11-12,14,17-18H2,1-3H3,(H,43,53)(H2,39,40,41)(H,45,52,54)(H2,42,44,47,56)","LUFIMFUAXRLQRQ-UHFFFAOYSA-N"
"2932","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","449.2","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","771.799","771.298975904","1.6","57","8","14","5","9","250.18","C38H37N13O6","InChI=1S/C38H37N13O6/c1-38(2,3)28-13-29(47-57-28)44-37(56)42-21-9-7-20(8-10-21)24-16-49(34-32(24)33(39)40-19-41-34)14-22-15-50(48-46-22)18-31(53)43-26-6-4-5-23-25(26)17-51(36(23)55)27-11-12-30(52)45-35(27)54/h4-10,13,15-16,19,27H,11-12,14,17-18H2,1-3H3,(H,43,53)(H2,39,40,41)(H,45,52,54)(H2,42,44,47,56)","LUFIMFUAXRLQRQ-UHFFFAOYSA-N"
"2933","P36888","FLT3","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.26/11.19","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","2.0","58","8","14","5","9","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-20(35(54)44-27-7-5-6-24-26(27)18-51(37(24)56)28-12-13-31(53)46-36(28)55)52-16-23(47-49-52)15-50-17-25(32-33(40)41-19-42-34(32)50)21-8-10-22(11-9-21)43-38(57)45-30-14-29(58-48-30)39(2,3)4/h5-11,14,16-17,19-20,28H,12-13,15,18H2,1-4H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","SQAREKRWYHORIG-UHFFFAOYSA-N"
"2933","P36888","FLT3-ITD","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","61.77","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","2.0","58","8","14","5","9","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-20(35(54)44-27-7-5-6-24-26(27)18-51(37(24)56)28-12-13-31(53)46-36(28)55)52-16-23(47-49-52)15-50-17-25(32-33(40)41-19-42-34(32)50)21-8-10-22(11-9-21)43-38(57)45-30-14-29(58-48-30)39(2,3)4/h5-11,14,16-17,19-20,28H,12-13,15,18H2,1-4H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","SQAREKRWYHORIG-UHFFFAOYSA-N"
"2933","P36888","FLT3-ITD-D835V","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","2.0","58","8","14","5","9","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-20(35(54)44-27-7-5-6-24-26(27)18-51(37(24)56)28-12-13-31(53)46-36(28)55)52-16-23(47-49-52)15-50-17-25(32-33(40)41-19-42-34(32)50)21-8-10-22(11-9-21)43-38(57)45-30-14-29(58-48-30)39(2,3)4/h5-11,14,16-17,19-20,28H,12-13,15,18H2,1-4H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","SQAREKRWYHORIG-UHFFFAOYSA-N"
"2933","P36888","FLT3-ITD-F691L","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","785.826","785.314625968","2.0","58","8","14","5","9","250.18","C39H39N13O6","InChI=1S/C39H39N13O6/c1-20(35(54)44-27-7-5-6-24-26(27)18-51(37(24)56)28-12-13-31(53)46-36(28)55)52-16-23(47-49-52)15-50-17-25(32-33(40)41-19-42-34(32)50)21-8-10-22(11-9-21)43-38(57)45-30-14-29(58-48-30)39(2,3)4/h5-11,14,16-17,19-20,28H,12-13,15,18H2,1-4H3,(H,44,54)(H2,40,41,42)(H,46,53,55)(H2,43,45,48,57)","SQAREKRWYHORIG-UHFFFAOYSA-N"
"2934","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.85/15.88","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","1.99","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-18-32(50-60-31)47-40(59)45-24-11-9-23(10-12-24)27-20-52(37-35(27)36(42)43-22-44-37)16-5-6-25-19-53(51-49-25)17-15-34(56)46-29-8-4-7-26-28(29)21-54(39(26)58)30-13-14-33(55)48-38(30)57/h4,7-12,18-20,22,30H,5-6,13-17,21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ORCOKXUIDWLXLM-UHFFFAOYSA-N"
"2934","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","1.99","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-18-32(50-60-31)47-40(59)45-24-11-9-23(10-12-24)27-20-52(37-35(27)36(42)43-22-44-37)16-5-6-25-19-53(51-49-25)17-15-34(56)46-29-8-4-7-26-28(29)21-54(39(26)58)30-13-14-33(55)48-38(30)57/h4,7-12,18-20,22,30H,5-6,13-17,21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ORCOKXUIDWLXLM-UHFFFAOYSA-N"
"2934","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","1.99","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-18-32(50-60-31)47-40(59)45-24-11-9-23(10-12-24)27-20-52(37-35(27)36(42)43-22-44-37)16-5-6-25-19-53(51-49-25)17-15-34(56)46-29-8-4-7-26-28(29)21-54(39(26)58)30-13-14-33(55)48-38(30)57/h4,7-12,18-20,22,30H,5-6,13-17,21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ORCOKXUIDWLXLM-UHFFFAOYSA-N"
"2934","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","1.99","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-18-32(50-60-31)47-40(59)45-24-11-9-23(10-12-24)27-20-52(37-35(27)36(42)43-22-44-37)16-5-6-25-19-53(51-49-25)17-15-34(56)46-29-8-4-7-26-28(29)21-54(39(26)58)30-13-14-33(55)48-38(30)57/h4,7-12,18-20,22,30H,5-6,13-17,21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ORCOKXUIDWLXLM-UHFFFAOYSA-N"
"2935","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15.63/32.69","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-7-26-20-54(52-50-26)18-6-10-34(56)47-30-9-4-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h4,8-9,11-14,19-21,23,31H,5-7,10,15-18,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","IZAUSFDRQPOFQK-UHFFFAOYSA-N"
"2935","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-7-26-20-54(52-50-26)18-6-10-34(56)47-30-9-4-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h4,8-9,11-14,19-21,23,31H,5-7,10,15-18,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","IZAUSFDRQPOFQK-UHFFFAOYSA-N"
"2935","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-7-26-20-54(52-50-26)18-6-10-34(56)47-30-9-4-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h4,8-9,11-14,19-21,23,31H,5-7,10,15-18,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","IZAUSFDRQPOFQK-UHFFFAOYSA-N"
"2935","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-13-11-24(12-14-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-7-26-20-54(52-50-26)18-6-10-34(56)47-30-9-4-8-27-29(30)22-55(40(27)59)31-15-16-35(57)49-39(31)58/h4,8-9,11-14,19-21,23,31H,5-7,10,15-18,22H2,1-3H3,(H,47,56)(H2,43,44,45)(H,49,57,58)(H2,46,48,51,60)","IZAUSFDRQPOFQK-UHFFFAOYSA-N"
"2936","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.61/35.09","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-7-8-27-21-55(53-51-27)19-5-4-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","DFTBULQMRFPAQN-UHFFFAOYSA-N"
"2936","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-7-8-27-21-55(53-51-27)19-5-4-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","DFTBULQMRFPAQN-UHFFFAOYSA-N"
"2936","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-7-8-27-21-55(53-51-27)19-5-4-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","DFTBULQMRFPAQN-UHFFFAOYSA-N"
"2936","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-7-8-27-21-55(53-51-27)19-5-4-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","DFTBULQMRFPAQN-UHFFFAOYSA-N"
"2937","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14.05/14.02","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-8-9-28-22-56(54-52-28)20-6-4-5-12-36(58)49-32-11-7-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h7,10-11,13-16,21-23,25,33H,4-6,8-9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","WYQRDBGVHZEXPB-UHFFFAOYSA-N"
"2937","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","53.07","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-8-9-28-22-56(54-52-28)20-6-4-5-12-36(58)49-32-11-7-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h7,10-11,13-16,21-23,25,33H,4-6,8-9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","WYQRDBGVHZEXPB-UHFFFAOYSA-N"
"2937","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","793.3","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-8-9-28-22-56(54-52-28)20-6-4-5-12-36(58)49-32-11-7-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h7,10-11,13-16,21-23,25,33H,4-6,8-9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","WYQRDBGVHZEXPB-UHFFFAOYSA-N"
"2937","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","849.4","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-8-9-28-22-56(54-52-28)20-6-4-5-12-36(58)49-32-11-7-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h7,10-11,13-16,21-23,25,33H,4-6,8-9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","WYQRDBGVHZEXPB-UHFFFAOYSA-N"
"2938","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.8/22.87","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","2.26","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-18-51(36-34(26)35(41)42-21-43-36)15-5-6-24-17-52(50-48-24)20-33(55)45-28-8-4-7-25-27(28)19-53(38(25)57)29-13-14-32(54)47-37(29)56/h4,7-12,16-18,21,29H,5-6,13-15,19-20H2,1-3H3,(H,45,55)(H2,41,42,43)(H,47,54,56)(H2,44,46,49,58)","SGMYPIWUTUREHW-UHFFFAOYSA-N"
"2938","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21.23","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","2.26","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-18-51(36-34(26)35(41)42-21-43-36)15-5-6-24-17-52(50-48-24)20-33(55)45-28-8-4-7-25-27(28)19-53(38(25)57)29-13-14-32(54)47-37(29)56/h4,7-12,16-18,21,29H,5-6,13-15,19-20H2,1-3H3,(H,45,55)(H2,41,42,43)(H,47,54,56)(H2,44,46,49,58)","SGMYPIWUTUREHW-UHFFFAOYSA-N"
"2938","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","449.9","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","2.26","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-18-51(36-34(26)35(41)42-21-43-36)15-5-6-24-17-52(50-48-24)20-33(55)45-28-8-4-7-25-27(28)19-53(38(25)57)29-13-14-32(54)47-37(29)56/h4,7-12,16-18,21,29H,5-6,13-15,19-20H2,1-3H3,(H,45,55)(H2,41,42,43)(H,47,54,56)(H2,44,46,49,58)","SGMYPIWUTUREHW-UHFFFAOYSA-N"
"2938","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","448.3","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","799.853","799.330276032","2.26","59","8","14","5","11","250.18","C40H41N13O6","InChI=1S/C40H41N13O6/c1-40(2,3)30-16-31(49-59-30)46-39(58)44-23-11-9-22(10-12-23)26-18-51(36-34(26)35(41)42-21-43-36)15-5-6-24-17-52(50-48-24)20-33(55)45-28-8-4-7-25-27(28)19-53(38(25)57)29-13-14-32(54)47-37(29)56/h4,7-12,16-18,21,29H,5-6,13-15,19-20H2,1-3H3,(H,45,55)(H2,41,42,43)(H,47,54,56)(H2,44,46,49,58)","SGMYPIWUTUREHW-UHFFFAOYSA-N"
"2939","P36888","FLT3","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13.12/20.04","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.66","60","8","14","5","11","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-22(37(56)46-29-9-5-8-26-28(29)20-53(39(26)58)30-14-15-33(55)48-38(30)57)54-18-25(49-51-54)7-6-16-52-19-27(34-35(42)43-21-44-36(34)52)23-10-12-24(13-11-23)45-40(59)47-32-17-31(60-50-32)41(2,3)4/h5,8-13,17-19,21-22,30H,6-7,14-16,20H2,1-4H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","TYXMRNZDDNBPHY-UHFFFAOYSA-N"
"2939","P36888","FLT3-ITD","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","52.08","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.66","60","8","14","5","11","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-22(37(56)46-29-9-5-8-26-28(29)20-53(39(26)58)30-14-15-33(55)48-38(30)57)54-18-25(49-51-54)7-6-16-52-19-27(34-35(42)43-21-44-36(34)52)23-10-12-24(13-11-23)45-40(59)47-32-17-31(60-50-32)41(2,3)4/h5,8-13,17-19,21-22,30H,6-7,14-16,20H2,1-4H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","TYXMRNZDDNBPHY-UHFFFAOYSA-N"
"2939","P36888","FLT3-ITD-D835V","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">1000","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.66","60","8","14","5","11","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-22(37(56)46-29-9-5-8-26-28(29)20-53(39(26)58)30-14-15-33(55)48-38(30)57)54-18-25(49-51-54)7-6-16-52-19-27(34-35(42)43-21-44-36(34)52)23-10-12-24(13-11-23)45-40(59)47-32-17-31(60-50-32)41(2,3)4/h5,8-13,17-19,21-22,30H,6-7,14-16,20H2,1-4H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","TYXMRNZDDNBPHY-UHFFFAOYSA-N"
"2939","P36888","FLT3-ITD-F691L","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","837.3","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.66","60","8","14","5","11","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-22(37(56)46-29-9-5-8-26-28(29)20-53(39(26)58)30-14-15-33(55)48-38(30)57)54-18-25(49-51-54)7-6-16-52-19-27(34-35(42)43-21-44-36(34)52)23-10-12-24(13-11-23)45-40(59)47-32-17-31(60-50-32)41(2,3)4/h5,8-13,17-19,21-22,30H,6-7,14-16,20H2,1-4H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","TYXMRNZDDNBPHY-UHFFFAOYSA-N"
"2940","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16.75/14.96","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-12-10-24(11-13-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-4-7-26-20-54(52-50-26)18-16-35(57)47-30-9-6-8-27-29(30)22-55(40(27)59)31-14-15-34(56)49-39(31)58/h6,8-13,19-21,23,31H,4-5,7,14-18,22H2,1-3H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","KGXXGHCWWKZXRF-UHFFFAOYSA-N"
"2940","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","32.74","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-12-10-24(11-13-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-4-7-26-20-54(52-50-26)18-16-35(57)47-30-9-6-8-27-29(30)22-55(40(27)59)31-14-15-34(56)49-39(31)58/h6,8-13,19-21,23,31H,4-5,7,14-18,22H2,1-3H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","KGXXGHCWWKZXRF-UHFFFAOYSA-N"
"2940","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","642.6","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-12-10-24(11-13-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-4-7-26-20-54(52-50-26)18-16-35(57)47-30-9-6-8-27-29(30)22-55(40(27)59)31-14-15-34(56)49-39(31)58/h6,8-13,19-21,23,31H,4-5,7,14-18,22H2,1-3H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","KGXXGHCWWKZXRF-UHFFFAOYSA-N"
"2940","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","559.2","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","2.35","61","8","14","5","13","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-42(2,3)32-19-33(51-61-32)48-41(60)46-25-12-10-24(11-13-25)28-21-53(38-36(28)37(43)44-23-45-38)17-5-4-7-26-20-54(52-50-26)18-16-35(57)47-30-9-6-8-27-29(30)22-55(40(27)59)31-14-15-34(56)49-39(31)58/h6,8-13,19-21,23,31H,4-5,7,14-18,22H2,1-3H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","KGXXGHCWWKZXRF-UHFFFAOYSA-N"
"2941","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13.2/11.71","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-5-4-8-27-21-55(53-51-27)19-7-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","KHWLKOLEBCFUEN-UHFFFAOYSA-N"
"2941","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31.65","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-5-4-8-27-21-55(53-51-27)19-7-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","KHWLKOLEBCFUEN-UHFFFAOYSA-N"
"2941","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","533.2","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-5-4-8-27-21-55(53-51-27)19-7-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","KHWLKOLEBCFUEN-UHFFFAOYSA-N"
"2941","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","575","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","841.934","841.377226224","2.71","62","8","14","5","14","250.18","C43H47N13O6","InChI=1S/C43H47N13O6/c1-43(2,3)33-20-34(52-62-33)49-42(61)47-26-14-12-25(13-15-26)29-22-54(39-37(29)38(44)45-24-46-39)18-5-4-8-27-21-55(53-51-27)19-7-11-35(57)48-31-10-6-9-28-30(31)23-56(41(28)60)32-16-17-36(58)50-40(32)59/h6,9-10,12-15,20-22,24,32H,4-5,7-8,11,16-19,23H2,1-3H3,(H,48,57)(H2,44,45,46)(H,50,58,59)(H2,47,49,52,61)","KHWLKOLEBCFUEN-UHFFFAOYSA-N"
"2942","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","76.7","","Degradation of FLT3-ITD in BaF3 FLT3-ITD cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.85","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","BQDQZCCNJKVYDD-UHFFFAOYSA-N"
"2942","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","36","Inhibition of FLT3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4.83/4.01","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","BQDQZCCNJKVYDD-UHFFFAOYSA-N"
"2942","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","120.1","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","BQDQZCCNJKVYDD-UHFFFAOYSA-N"
"2942","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","116.6","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","855.961","855.392876288","3.06","63","8","14","5","15","250.18","C44H49N13O6","InChI=1S/C44H49N13O6/c1-44(2,3)34-21-35(53-63-34)50-43(62)48-27-15-13-26(14-16-27)30-23-55(40-38(30)39(45)46-25-47-40)19-6-4-9-28-22-56(54-52-28)20-7-5-12-36(58)49-32-11-8-10-29-31(32)24-57(42(29)61)33-17-18-37(59)51-41(33)60/h8,10-11,13-16,21-23,25,33H,4-7,9,12,17-20,24H2,1-3H3,(H,49,58)(H2,45,46,47)(H,51,59,60)(H2,48,50,53,62)","BQDQZCCNJKVYDD-UHFFFAOYSA-N"
"2943","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.82/2.1","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","869.988","869.408526352","3.42","64","8","14","5","16","250.18","C45H51N13O6","InChI=1S/C45H51N13O6/c1-45(2,3)35-22-36(54-64-35)51-44(63)49-28-16-14-27(15-17-28)31-24-56(41-39(31)40(46)47-26-48-41)20-8-6-10-29-23-57(55-53-29)21-7-4-5-13-37(59)50-33-12-9-11-30-32(33)25-58(43(30)62)34-18-19-38(60)52-42(34)61/h9,11-12,14-17,22-24,26,34H,4-8,10,13,18-21,25H2,1-3H3,(H,50,59)(H2,46,47,48)(H,52,60,61)(H2,49,51,54,63)","ZMYIVHKERNSKAB-UHFFFAOYSA-N"
"2943","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.09","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","869.988","869.408526352","3.42","64","8","14","5","16","250.18","C45H51N13O6","InChI=1S/C45H51N13O6/c1-45(2,3)35-22-36(54-64-35)51-44(63)49-28-16-14-27(15-17-28)31-24-56(41-39(31)40(46)47-26-48-41)20-8-6-10-29-23-57(55-53-29)21-7-4-5-13-37(59)50-33-12-9-11-30-32(33)25-58(43(30)62)34-18-19-38(60)52-42(34)61/h9,11-12,14-17,22-24,26,34H,4-8,10,13,18-21,25H2,1-3H3,(H,50,59)(H2,46,47,48)(H,52,60,61)(H2,49,51,54,63)","ZMYIVHKERNSKAB-UHFFFAOYSA-N"
"2943","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","193","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","869.988","869.408526352","3.42","64","8","14","5","16","250.18","C45H51N13O6","InChI=1S/C45H51N13O6/c1-45(2,3)35-22-36(54-64-35)51-44(63)49-28-16-14-27(15-17-28)31-24-56(41-39(31)40(46)47-26-48-41)20-8-6-10-29-23-57(55-53-29)21-7-4-5-13-37(59)50-33-12-9-11-30-32(33)25-58(43(30)62)34-18-19-38(60)52-42(34)61/h9,11-12,14-17,22-24,26,34H,4-8,10,13,18-21,25H2,1-3H3,(H,50,59)(H2,46,47,48)(H,52,60,61)(H2,49,51,54,63)","ZMYIVHKERNSKAB-UHFFFAOYSA-N"
"2943","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CCCCCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","172.4","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","869.988","869.408526352","3.42","64","8","14","5","16","250.18","C45H51N13O6","InChI=1S/C45H51N13O6/c1-45(2,3)35-22-36(54-64-35)51-44(63)49-28-16-14-27(15-17-28)31-24-56(41-39(31)40(46)47-26-48-41)20-8-6-10-29-23-57(55-53-29)21-7-4-5-13-37(59)50-33-12-9-11-30-32(33)25-58(43(30)62)34-18-19-38(60)52-42(34)61/h9,11-12,14-17,22-24,26,34H,4-8,10,13,18-21,25H2,1-3H3,(H,50,59)(H2,46,47,48)(H,52,60,61)(H2,49,51,54,63)","ZMYIVHKERNSKAB-UHFFFAOYSA-N"
"2944","P36888","FLT3","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12.32/17.05","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.61","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-19-52(37-35(27)36(42)43-22-44-37)16-5-4-7-25-18-53(51-49-25)21-34(56)46-29-9-6-8-26-28(29)20-54(39(26)58)30-14-15-33(55)48-38(30)57/h6,8-13,17-19,22,30H,4-5,7,14-16,20-21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ZGSVIHMHCHGXKW-UHFFFAOYSA-N"
"2944","P36888","FLT3-ITD","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31.74","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.61","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-19-52(37-35(27)36(42)43-22-44-37)16-5-4-7-25-18-53(51-49-25)21-34(56)46-29-9-6-8-26-28(29)20-54(39(26)58)30-14-15-33(55)48-38(30)57/h6,8-13,17-19,22,30H,4-5,7,14-16,20-21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ZGSVIHMHCHGXKW-UHFFFAOYSA-N"
"2944","P36888","FLT3-ITD-D835V","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","656.7","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.61","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-19-52(37-35(27)36(42)43-22-44-37)16-5-4-7-25-18-53(51-49-25)21-34(56)46-29-9-6-8-26-28(29)20-54(39(26)58)30-14-15-33(55)48-38(30)57/h6,8-13,17-19,22,30H,4-5,7,14-16,20-21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ZGSVIHMHCHGXKW-UHFFFAOYSA-N"
"2944","P36888","FLT3-ITD-F691L","CRBN","","","CC(C)(C)C1=CC(NC(=O)NC2=CC=C(C3=CN(CCCCC4=CN(CC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)N=N4)C4=NC=NC(N)=C34)C=C2)=NO1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","722.8","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","813.88","813.345926096","2.61","60","8","14","5","12","250.18","C41H43N13O6","InChI=1S/C41H43N13O6/c1-41(2,3)31-17-32(50-60-31)47-40(59)45-24-12-10-23(11-13-24)27-19-52(37-35(27)36(42)43-22-44-37)16-5-4-7-25-18-53(51-49-25)21-34(56)46-29-9-6-8-26-28(29)20-54(39(26)58)30-14-15-33(55)48-38(30)57/h6,8-13,17-19,22,30H,4-5,7,14-16,20-21H2,1-3H3,(H,46,56)(H2,42,43,44)(H,48,55,57)(H2,45,47,50,59)","ZGSVIHMHCHGXKW-UHFFFAOYSA-N"
"2945","P36888","FLT3","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9.73/31.93","Inhibit proliferation of MV4-11/Molm-13 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","3.01","61","8","14","5","12","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-23(38(57)47-30-10-7-9-27-29(30)21-54(40(27)59)31-15-16-34(56)49-39(31)58)55-19-26(50-52-55)8-5-6-17-53-20-28(35-36(43)44-22-45-37(35)53)24-11-13-25(14-12-24)46-41(60)48-33-18-32(61-51-33)42(2,3)4/h7,9-14,18-20,22-23,31H,5-6,8,15-17,21H2,1-4H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","PZLOIEOALKDKIP-UHFFFAOYSA-N"
"2945","P36888","FLT3-ITD","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","23.14","Inhibit proliferation of BaF3 FLT3-ITD cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","3.01","61","8","14","5","12","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-23(38(57)47-30-10-7-9-27-29(30)21-54(40(27)59)31-15-16-34(56)49-39(31)58)55-19-26(50-52-55)8-5-6-17-53-20-28(35-36(43)44-22-45-37(35)53)24-11-13-25(14-12-24)46-41(60)48-33-18-32(61-51-33)42(2,3)4/h7,9-14,18-20,22-23,31H,5-6,8,15-17,21H2,1-4H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","PZLOIEOALKDKIP-UHFFFAOYSA-N"
"2945","P36888","FLT3-ITD-D835V","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","719","Inhibit proliferation of BaF3 FLT3-ITD-D835V cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","3.01","61","8","14","5","12","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-23(38(57)47-30-10-7-9-27-29(30)21-54(40(27)59)31-15-16-34(56)49-39(31)58)55-19-26(50-52-55)8-5-6-17-53-20-28(35-36(43)44-22-45-37(35)53)24-11-13-25(14-12-24)46-41(60)48-33-18-32(61-51-33)42(2,3)4/h7,9-14,18-20,22-23,31H,5-6,8,15-17,21H2,1-4H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","PZLOIEOALKDKIP-UHFFFAOYSA-N"
"2945","P36888","FLT3-ITD-F691L","CRBN","","","CC(C(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)N1C=C(CCCCN2C=C(C3=CC=C(NC(=O)NC4=NOC(C(C)(C)C)=C4)C=C3)C3=C(N)N=CN=C32)N=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","546.6","Inhibit proliferation of BaF3 FLT3-ITD-F691L cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105508","827.907","827.36157616","3.01","61","8","14","5","12","250.18","C42H45N13O6","InChI=1S/C42H45N13O6/c1-23(38(57)47-30-10-7-9-27-29(30)21-54(40(27)59)31-15-16-34(56)49-39(31)58)55-19-26(50-52-55)8-5-6-17-53-20-28(35-36(43)44-22-45-37(35)53)24-11-13-25(14-12-24)46-41(60)48-33-18-32(61-51-33)42(2,3)4/h7,9-14,18-20,22-23,31H,5-6,8,15-17,21H2,1-4H3,(H,47,57)(H2,43,44,45)(H,49,56,58)(H2,46,48,51,60)","PZLOIEOALKDKIP-UHFFFAOYSA-N"
"2946","P01106","MYC","CRBN","","MDEG-541","CC(C)C1=CC=C(/C=C2\SC(=S)N(CCCCCCCCNC(=O)C3=CC=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=C3)C2=O)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14300/10700","Inhibit viability of HCT116/PSN1 cells","","","","","","","","","","","10.1016/j.bioorg.2021.105505","674.845","674.223276936","5.79","47","5","8","2","13","132.96","C35H38N4O6S2","InChI=1S/C35H38N4O6S2/c1-21(2)23-11-9-22(10-12-23)19-28-34(45)38(35(46)47-28)18-8-6-4-3-5-7-17-36-30(41)24-13-14-25-26(20-24)33(44)39(32(25)43)27-15-16-29(40)37-31(27)42/h9-14,19-21,27H,3-8,15-18H2,1-2H3,(H,36,41)(H,37,40,42)/b28-19-","GFYSITXCVIHVSN-USHMODERSA-N"
"2947","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","760/630/450","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","843.119","842.5193652","7.23","61","8","9","4","12","163.37","C49H70N4O8","InChI=1S/C49H70N4O8/c1-29-15-20-49(22-21-47(6)32(40(49)30(29)2)11-13-36-46(5)18-17-37(54)45(3,4)35(46)16-19-48(36,47)7)44(59)51-24-26-61-28-27-60-25-23-50-33-10-8-9-31-39(33)43(58)53(42(31)57)34-12-14-38(55)52-41(34)56/h8-11,29-30,34-37,40,50,54H,12-28H2,1-7H3,(H,51,59)(H,52,55,56)/t29-,30+,34?,35?,36-,37+,40+,46+,47-,48-,49+/m1/s1","QADRBGFHJAYATN-JLEVPBQDSA-N"
"2948","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)NCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","230/390/380","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","887.172","886.545579948","7.09","64","8","10","4","15","172.6","C51H74N4O9","InChI=1S/C51H74N4O9/c1-31-15-20-51(22-21-49(6)34(42(51)32(31)2)11-13-38-48(5)18-17-39(56)47(3,4)37(48)16-19-50(38,49)7)46(61)53-24-26-63-28-30-64-29-27-62-25-23-52-35-10-8-9-33-41(35)45(60)55(44(33)59)36-12-14-40(57)54-43(36)58/h8-11,31-32,36-39,42,52,56H,12-30H2,1-7H3,(H,53,61)(H,54,57,58)/t31-,32+,36?,37?,38-,39+,42+,48+,49-,50-,51+/m1/s1","DJCSCTSFEKKYEJ-VJHVGAIPSA-N"
"2949","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)NCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","890/960/900","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","931.225","930.571794696","6.94","67","8","11","4","18","181.83","C53H78N4O10","InChI=1S/C53H78N4O10/c1-33-15-20-53(22-21-51(6)36(44(53)34(33)2)11-13-40-50(5)18-17-41(58)49(3,4)39(50)16-19-52(40,51)7)48(63)55-24-26-65-28-30-67-32-31-66-29-27-64-25-23-54-37-10-8-9-35-43(37)47(62)57(46(35)61)38-12-14-42(59)56-45(38)60/h8-11,33-34,38-41,44,54,58H,12-32H2,1-7H3,(H,55,63)(H,56,59,60)/t33-,34+,38?,39?,40-,41+,44+,50+,51-,52-,53+/m1/s1","YXEDULFZUBCQCQ-PEMJVTLKSA-N"
"2950","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)OCCOC(=O)CCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1530/1810/1590","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","960.219","959.550724904","7.49","69","8","13","3","18","196.1","C54H77N3O12","InChI=1S/C54H77N3O12/c1-33-15-21-54(23-22-52(6)36(45(54)34(33)2)11-13-40-51(5)19-17-41(58)50(3,4)39(51)16-20-53(40,52)7)49(64)69-32-31-68-43(60)18-25-65-27-29-67-30-28-66-26-24-55-37-10-8-9-35-44(37)48(63)57(47(35)62)38-12-14-42(59)56-46(38)61/h8-11,33-34,38-41,45,55,58H,12-32H2,1-7H3,(H,56,59,61)/t33-,34+,38?,39?,40-,41+,45+,51+,52-,53-,54+/m1/s1","QZXBBTGXUKUKFZ-GRTARIGISA-N"
"2951","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)OCCOC(=O)CCOCCOCCN2C=C(CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1890/1870/1770","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","997.244","996.557207252","6.86","72","9","15","3","17","217.58","C55H76N6O11","InChI=1S/C55H76N6O11/c1-33-15-21-55(23-22-53(6)37(46(55)34(33)2)11-13-41-52(5)19-17-42(62)51(3,4)40(52)16-20-54(41,53)7)50(68)72-30-29-71-44(64)18-25-69-27-28-70-26-24-60-32-35(58-59-60)31-56-38-10-8-9-36-45(38)49(67)61(48(36)66)39-12-14-43(63)57-47(39)65/h8-11,32-34,39-42,46,56,62H,12-31H2,1-7H3,(H,57,63,65)/t33-,34+,39?,40?,41-,42+,46+,52+,53-,54-,55+/m1/s1","UOJHNMBTUWBUNP-NCSKWKBRSA-N"
"2952","Q00987","MDM2","CRBN","","","C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)NCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC[C@H]1C","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1360/1470/1780","Inhibit proliferation of A549/Huh7/HepG2 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104901","839.175","838.560836088","10.04","61","8","7","4","12","144.91","C51H74N4O6","InChI=1S/C51H74N4O6/c1-31-21-26-51(28-27-49(6)34(42(51)32(31)2)17-19-38-48(5)24-23-39(56)47(3,4)37(48)22-25-50(38,49)7)46(61)53-30-13-11-9-8-10-12-29-52-35-16-14-15-33-41(35)45(60)55(44(33)59)36-18-20-40(57)54-43(36)58/h14-17,31-32,36-39,42,52,56H,8-13,18-30H2,1-7H3,(H,53,61)(H,54,57,58)/t31-,32+,36?,37?,38-,39+,42+,48+,49-,50-,51+/m1/s1","GWAFNWYTFYCSEM-VJHVGAIPSA-N"
"2953","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2620/15410/9570","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","690.797","690.305349684","5.84","51","6","9","3","15","135.3","C40H42N4O7","InChI=1S/C40H42N4O7/c1-25-27(13-9-14-29(25)26-11-5-4-6-12-26)24-51-28-21-34(49-2)31(35(22-28)50-3)23-41-19-7-8-20-42-32-16-10-15-30-37(32)40(48)44(39(30)47)33-17-18-36(45)43-38(33)46/h4-6,9-16,21-22,33,41-42H,7-8,17-20,23-24H2,1-3H3,(H,43,45,46)","FPUTZWBDWXNSQB-UHFFFAOYSA-N"
"2954","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","21180/51010/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","704.824","704.320999748","6.2","52","6","9","3","16","135.3","C41H44N4O7","InChI=1S/C41H44N4O7/c1-26-28(14-10-15-30(26)27-12-6-4-7-13-27)25-52-29-22-35(50-2)32(36(23-29)51-3)24-42-20-8-5-9-21-43-33-17-11-16-31-38(33)41(49)45(40(31)48)34-18-19-37(46)44-39(34)47/h4,6-7,10-17,22-23,34,42-43H,5,8-9,18-21,24-25H2,1-3H3,(H,44,46,47)","CQKPDSZJJDPFQA-UHFFFAOYSA-N"
"2955","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","45040/50510/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","718.851","718.336649812","6.55","53","6","9","3","17","135.3","C42H46N4O7","InChI=1S/C42H46N4O7/c1-27-29(15-11-16-31(27)28-13-7-6-8-14-28)26-53-30-23-36(51-2)33(37(24-30)52-3)25-43-21-9-4-5-10-22-44-34-18-12-17-32-39(34)42(50)46(41(32)49)35-19-20-38(47)45-40(35)48/h6-8,11-18,23-24,35,43-44H,4-5,9-10,19-22,25-26H2,1-3H3,(H,45,47,48)","OUVAFLZCTFPDBQ-UHFFFAOYSA-N"
"2956","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1230/10830/4230","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","732.878","732.352299876","7.09","54","6","9","3","18","135.3","C43H48N4O7","InChI=1S/C43H48N4O7/c1-28-30(16-12-17-32(28)29-14-8-7-9-15-29)27-54-31-24-37(52-2)34(38(25-31)53-3)26-44-22-10-5-4-6-11-23-45-35-19-13-18-33-40(35)43(51)47(42(33)50)36-20-21-39(48)46-41(36)49/h7-9,12-19,24-25,36,44-45H,4-6,10-11,20-23,26-27H2,1-3H3,(H,46,48,49)","JHQKUGHPDDQDGO-UHFFFAOYSA-N"
"2957","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2140/3150/2100","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","746.905","746.36794994","7.64","55","6","9","3","19","135.3","C44H50N4O7","InChI=1S/C44H50N4O7/c1-29-31(17-13-18-33(29)30-15-9-8-10-16-30)28-55-32-25-38(53-2)35(39(26-32)54-3)27-45-23-11-6-4-5-7-12-24-46-36-20-14-19-34-41(36)44(52)48(43(34)51)37-21-22-40(49)47-42(37)50/h8-10,13-20,25-26,37,45-46H,4-7,11-12,21-24,27-28H2,1-3H3,(H,47,49,50)","BJHSBZVKJDVKDF-UHFFFAOYSA-N"
"2958","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCCCCCCCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8390/17330/14810","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","760.932","760.383600004","8.18","56","6","9","3","20","135.3","C45H52N4O7","InChI=1S/C45H52N4O7/c1-30-32(18-14-19-34(30)31-16-10-9-11-17-31)29-56-33-26-39(54-2)36(40(27-33)55-3)28-46-24-12-7-5-4-6-8-13-25-47-37-21-15-20-35-42(37)45(53)49(44(35)52)38-22-23-41(50)48-43(38)51/h9-11,14-21,26-27,38,46-47H,4-8,12-13,22-25,28-29H2,1-3H3,(H,48,50,51)","AMCKDKDCBSCOFJ-UHFFFAOYSA-N"
"2959","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=C(C3=CC=CC=C3)C=C2C)=CC(OC)=C1CNCCNC(=O)CCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7570/33310/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","742.829","742.300264304","4.49","55","6","9","3","14","152.37","C43H42N4O8","InChI=1S/C43H42N4O8/c1-27-21-30(29-10-5-4-6-11-29)14-15-31(27)26-55-32-23-37(53-2)35(38(24-32)54-3)25-44-19-20-45-39(48)12-8-7-9-28-13-16-33-34(22-28)43(52)47(42(33)51)36-17-18-40(49)46-41(36)50/h4-6,10-11,13-16,21-24,36,44H,8,12,17-20,25-26H2,1-3H3,(H,45,48)(H,46,49,50)","LXEZNGMQGURECE-UHFFFAOYSA-N"
"2960","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCNC(=O)CCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">100000/80780/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","756.856","756.315914368","4.85","56","6","9","3","15","152.37","C44H44N4O8","InChI=1S/C44H44N4O8/c1-28-31(14-10-15-33(28)30-12-7-5-8-13-30)27-56-32-24-38(54-2)36(39(25-32)55-3)26-45-21-22-46-40(49)16-9-4-6-11-29-17-18-34-35(23-29)44(53)48(43(34)52)37-19-20-41(50)47-42(37)51/h5,7-8,10,12-15,17-18,23-25,37,45H,4,9,16,19-22,26-27H2,1-3H3,(H,46,49)(H,47,50,51)","VRDCJEWVOSAMGL-UHFFFAOYSA-N"
"2961","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCNC(=O)CCCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","25340/27010/10250","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","770.883","770.331564432","5.39","57","6","9","3","16","152.37","C45H46N4O8","InChI=1S/C45H46N4O8/c1-29-32(15-11-16-34(29)31-13-8-6-9-14-31)28-57-33-25-39(55-2)37(40(26-33)56-3)27-46-22-23-47-41(50)17-10-5-4-7-12-30-18-19-35-36(24-30)45(54)49(44(35)53)38-20-21-42(51)48-43(38)52/h6,8-9,11,13-16,18-19,24-26,38,46H,4-5,10,17,20-23,27-28H2,1-3H3,(H,47,50)(H,48,51,52)","BRTVDDLQZZTSPW-UHFFFAOYSA-N"
"2962","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=C(C3=CC=CC=C3)C=C2C)=CC(OC)=C1CNCCNC(=O)CCC#CC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","22050/30880/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","742.829","742.300264304","4.49","55","6","9","3","14","152.37","C43H42N4O8","InChI=1S/C43H42N4O8/c1-27-22-30(28-10-5-4-6-11-28)16-17-31(27)26-55-32-23-36(53-2)34(37(24-32)54-3)25-44-20-21-45-38(48)15-8-7-12-29-13-9-14-33-40(29)43(52)47(42(33)51)35-18-19-39(49)46-41(35)50/h4-6,9-11,13-14,16-17,22-24,35,44H,8,15,18-21,25-26H2,1-3H3,(H,45,48)(H,46,49,50)","LSVSEXXQBZYGEO-UHFFFAOYSA-N"
"2963","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCNC(=O)CCCC#CC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7570/>100000/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","756.856","756.315914368","4.85","56","6","9","3","15","152.37","C44H44N4O8","InChI=1S/C44H44N4O8/c1-28-31(16-11-17-33(28)29-12-6-4-7-13-29)27-56-32-24-37(54-2)35(38(25-32)55-3)26-45-22-23-46-39(49)19-9-5-8-14-30-15-10-18-34-41(30)44(53)48(43(34)52)36-20-21-40(50)47-42(36)51/h4,6-7,10-13,15-18,24-25,36,45H,5,9,19-23,26-27H2,1-3H3,(H,46,49)(H,47,50,51)","GCAOMZWAXBVXAS-UHFFFAOYSA-N"
"2964","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCNC(=O)CCCCC#CC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5980/15960/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","770.883","770.331564432","5.39","57","6","9","3","16","152.37","C45H46N4O8","InChI=1S/C45H46N4O8/c1-29-32(17-12-18-34(29)30-13-8-6-9-14-30)28-57-33-25-38(55-2)36(39(26-33)56-3)27-46-23-24-47-40(50)20-10-5-4-7-15-31-16-11-19-35-42(31)45(54)49(44(35)53)37-21-22-41(51)48-43(37)52/h6,8-9,11-14,16-19,25-26,37,46H,4-5,10,20-24,27-28H2,1-3H3,(H,47,50)(H,48,51,52)","WUDPMDMXYVGEDN-UHFFFAOYSA-N"
"2965","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCC(=O)NCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12080/57590/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","777.831","777.300992576","3.25","57","6","11","4","17","190.7","C42H43N5O10","InChI=1S/C42H43N5O10/c1-25-27(11-7-12-29(25)26-9-5-4-6-10-26)23-56-28-19-34(54-2)31(35(20-28)55-3)21-43-22-37(49)44-17-18-45-38(50)24-57-33-14-8-13-30-39(33)42(53)47(41(30)52)32-15-16-36(48)46-40(32)51/h4-14,19-20,32,43H,15-18,21-24H2,1-3H3,(H,44,49)(H,45,50)(H,46,48,51)","SQPPTUOJWRGUEF-UHFFFAOYSA-N"
"2966","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=C(C3=CC=CC=C3)C(C)=C2)=CC(OC)=C1CNCC(=O)NCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17880/19200/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","791.858","791.31664264","3.61","58","6","11","4","18","190.7","C43H45N5O10","InChI=1S/C43H45N5O10/c1-26-19-27(13-14-30(26)28-9-5-4-6-10-28)24-57-29-20-35(55-2)32(36(21-29)56-3)22-44-23-38(50)45-17-8-18-46-39(51)25-58-34-12-7-11-31-40(34)43(54)48(42(31)53)33-15-16-37(49)47-41(33)52/h4-7,9-14,19-21,33,44H,8,15-18,22-25H2,1-3H3,(H,45,50)(H,46,51)(H,47,49,52)","KWYLRCYWRJTFLF-UHFFFAOYSA-N"
"2967","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=C(C3=CC=CC=C3)C(C)=C2)=CC(OC)=C1CNCC(=O)NCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","5910/18550/26330","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","819.912","819.347942768","4.32","60","6","11","4","20","190.7","C45H49N5O10","InChI=1S/C45H49N5O10/c1-28-21-29(15-16-32(28)30-11-6-4-7-12-30)26-59-31-22-37(57-2)34(38(23-31)58-3)24-46-25-40(52)47-19-8-5-9-20-48-41(53)27-60-36-14-10-13-33-42(36)45(56)50(44(33)55)35-17-18-39(51)49-43(35)54/h4,6-7,10-16,21-23,35,46H,5,8-9,17-20,24-27H2,1-3H3,(H,47,52)(H,48,53)(H,49,51,54)","OIDDDVCCDGNXIF-UHFFFAOYSA-N"
"2968","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=C(C3=CC=CC=C3)C(C)=C2)=CC(OC)=C1CNCC(=O)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7323/7110/10520","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","833.939","833.363592832","4.68","61","6","11","4","21","190.7","C46H51N5O10","InChI=1S/C46H51N5O10/c1-29-22-30(16-17-33(29)31-12-7-6-8-13-31)27-60-32-23-38(58-2)35(39(24-32)59-3)25-47-26-41(53)48-20-9-4-5-10-21-49-42(54)28-61-37-15-11-14-34-43(37)46(57)51(45(34)56)36-18-19-40(52)50-44(36)55/h6-8,11-17,22-24,36,47H,4-5,9-10,18-21,25-28H2,1-3H3,(H,48,53)(H,49,54)(H,50,52,55)","YMGBXVPNBMRLJK-UHFFFAOYSA-N"
"2969","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCC(=O)NCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","16660/67610/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","805.885","805.332292704","3.51","59","6","11","4","19","190.7","C44H47N5O10","InChI=1S/C44H47N5O10/c1-27-29(12-7-13-31(27)28-10-5-4-6-11-28)25-58-30-22-36(56-2)33(37(23-30)57-3)24-45-21-18-38(50)46-19-9-20-47-40(52)26-59-35-15-8-14-32-41(35)44(55)49(43(32)54)34-16-17-39(51)48-42(34)53/h4-8,10-15,22-23,34,45H,9,16-21,24-26H2,1-3H3,(H,46,50)(H,47,52)(H,48,51,53)","LSPVNIQZKUYTSM-UHFFFAOYSA-N"
"2970","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCC(=O)NCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27410/28650/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","819.912","819.347942768","3.87","60","6","11","4","20","190.7","C45H49N5O10","InChI=1S/C45H49N5O10/c1-28-30(13-9-14-32(28)29-11-5-4-6-12-29)26-59-31-23-37(57-2)34(38(24-31)58-3)25-46-22-19-39(51)47-20-7-8-21-48-41(53)27-60-36-16-10-15-33-42(36)45(56)50(44(33)55)35-17-18-40(52)49-43(35)54/h4-6,9-16,23-24,35,46H,7-8,17-22,25-27H2,1-3H3,(H,47,51)(H,48,53)(H,49,52,54)","CUIZQHKHUPPEHD-UHFFFAOYSA-N"
"2971","Q9NZQ7","PD-L1","CRBN","","","COC1=CC(OCC2=CC=CC(C3=CC=CC=C3)=C2C)=CC(OC)=C1CNCCC(=O)NCCCCCCNC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12990/14860/>100000","Inhibit proliferation of B16F10/4T1/MC-38 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.104833","847.966","847.379242896","4.58","62","6","11","4","22","190.7","C47H53N5O10","InChI=1S/C47H53N5O10/c1-30-32(15-11-16-34(30)31-13-7-6-8-14-31)28-61-33-25-39(59-2)36(40(26-33)60-3)27-48-24-21-41(53)49-22-9-4-5-10-23-50-43(55)29-62-38-18-12-17-35-44(38)47(58)52(46(35)57)37-19-20-42(54)51-45(37)56/h6-8,11-18,25-26,37,48H,4-5,9-10,19-24,27-29H2,1-3H3,(H,49,53)(H,50,55)(H,51,54,56)","KRDCANARAODIMW-UHFFFAOYSA-N"
"2972","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","798.08","796.15819512","3.75","54","6","9","3","11","174.53","C37H35Cl3N6O8","InChI=1S/C37H35Cl3N6O8/c1-54-29-19-26(40)23(22-17-20(38)5-6-25(22)39)18-24(29)35(51)45-15-13-44(14-16-45)32(49)10-9-30(47)42-12-11-41-27-4-2-3-21-33(27)37(53)46(36(21)52)28-7-8-31(48)43-34(28)50/h2-6,17-19,28,41H,7-16H2,1H3,(H,42,47)(H,43,48,50)","HLMVQXVIXGMRRQ-UHFFFAOYSA-N"
"2973","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","812.107","810.173845184","4.11","55","6","9","3","12","174.53","C38H37Cl3N6O8","InChI=1S/C38H37Cl3N6O8/c1-55-30-20-27(41)24(23-18-21(39)6-7-26(23)40)19-25(30)36(52)46-16-14-45(15-17-46)33(50)11-10-31(48)43-13-3-12-42-28-5-2-4-22-34(28)38(54)47(37(22)53)29-8-9-32(49)44-35(29)51/h2,4-7,18-20,29,42H,3,8-17H2,1H3,(H,43,48)(H,44,49,51)","UZRJYIZUCPZYJI-UHFFFAOYSA-N"
"2974","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","826.134","824.189495248","4.47","56","6","9","3","13","174.53","C39H39Cl3N6O8","InChI=1S/C39H39Cl3N6O8/c1-56-31-21-28(42)25(24-19-22(40)7-8-27(24)41)20-26(31)37(53)47-17-15-46(16-18-47)34(51)12-11-32(49)44-14-3-2-13-43-29-6-4-5-23-35(29)39(55)48(38(23)54)30-9-10-33(50)45-36(30)52/h4-8,19-21,30,43H,2-3,9-18H2,1H3,(H,44,49)(H,45,50,52)","UAXZTIJCPPOETM-UHFFFAOYSA-N"
"2975","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)NCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","840.161","838.205145312","4.82","57","6","9","3","14","174.53","C40H41Cl3N6O8","InChI=1S/C40H41Cl3N6O8/c1-57-32-22-29(43)26(25-20-23(41)8-9-28(25)42)21-27(32)38(54)48-18-16-47(17-19-48)35(52)13-12-33(50)45-15-4-2-3-14-44-30-7-5-6-24-36(30)40(56)49(39(24)55)31-10-11-34(51)46-37(31)53/h5-9,20-22,31,44H,2-4,10-19H2,1H3,(H,45,50)(H,46,51,53)","YSYCCNJLCNOVCE-UHFFFAOYSA-N"
"2976","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","854.188","852.220795376","5.18","58","6","9","3","15","174.53","C41H43Cl3N6O8","InChI=1S/C41H43Cl3N6O8/c1-58-33-23-30(44)27(26-21-24(42)9-10-29(26)43)22-28(33)39(55)49-19-17-48(18-20-49)36(53)14-13-34(51)46-16-5-3-2-4-15-45-31-8-6-7-25-37(31)41(57)50(40(25)56)32-11-12-35(52)47-38(32)54/h6-10,21-23,32,45H,2-5,11-20H2,1H3,(H,46,51)(H,47,52,54)","TXFITMLSGXDVKI-UHFFFAOYSA-N"
"2977","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)N2CCN(CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","924.239","922.23750806","3.09","63","7","11","3","13","198.08","C43H45Cl3N8O9","InChI=1S/C43H45Cl3N8O9/c1-63-34-23-31(46)28(27-21-25(44)5-6-30(27)45)22-29(34)41(60)53-19-17-52(18-20-53)38(58)10-9-37(57)51-15-13-50(14-16-51)24-36(56)48-12-11-47-32-4-2-3-26-39(32)43(62)54(42(26)61)33-7-8-35(55)49-40(33)59/h2-6,21-23,33,47H,7-20,24H2,1H3,(H,48,56)(H,49,55,59)","GLIPFYKGHVSSRL-UHFFFAOYSA-N"
"2978","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)N2CCN(CC(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","938.266","936.253158124","3.45","64","7","11","3","14","198.08","C44H47Cl3N8O9","InChI=1S/C44H47Cl3N8O9/c1-64-35-24-32(47)29(28-22-26(45)6-7-31(28)46)23-30(35)42(61)54-20-18-53(19-21-54)39(59)11-10-38(58)52-16-14-51(15-17-52)25-37(57)49-13-3-12-48-33-5-2-4-27-40(33)44(63)55(43(27)62)34-8-9-36(56)50-41(34)60/h2,4-7,22-24,34,48H,3,8-21,25H2,1H3,(H,49,57)(H,50,56,60)","VHCSEYYUSWRVMO-UHFFFAOYSA-N"
"2979","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)N2CCN(CC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","952.293","950.268808188","3.8","65","7","11","3","15","198.08","C45H49Cl3N8O9","InChI=1S/C45H49Cl3N8O9/c1-65-36-25-33(48)30(29-23-27(46)7-8-32(29)47)24-31(36)43(62)55-21-19-54(20-22-55)40(60)12-11-39(59)53-17-15-52(16-18-53)26-38(58)50-14-3-2-13-49-34-6-4-5-28-41(34)45(64)56(44(28)63)35-9-10-37(57)51-42(35)61/h4-8,23-25,35,49H,2-3,9-22,26H2,1H3,(H,50,58)(H,51,57,61)","QOXJYSRYRQSXMV-UHFFFAOYSA-N"
"2980","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)N2CCN(CC(=O)NCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","966.32","964.284458252","4.16","66","7","11","3","16","198.08","C46H51Cl3N8O9","InChI=1S/C46H51Cl3N8O9/c1-66-37-26-34(49)31(30-24-28(47)8-9-33(30)48)25-32(37)44(63)56-22-20-55(21-23-56)41(61)13-12-40(60)54-18-16-53(17-19-54)27-39(59)51-15-4-2-3-14-50-35-7-5-6-29-42(35)46(65)57(45(29)64)36-10-11-38(58)52-43(36)62/h5-9,24-26,36,50H,2-4,10-23,27H2,1H3,(H,51,59)(H,52,58,62)","DSRGTJNSMDRHJY-UHFFFAOYSA-N"
"2981","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)CCC(=O)N2CCN(CC(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","980.347","978.300108316","4.52","67","7","11","3","17","198.08","C47H53Cl3N8O9","InChI=1S/C47H53Cl3N8O9/c1-67-38-27-35(50)32(31-25-29(48)9-10-34(31)49)26-33(38)45(64)57-23-21-56(22-24-57)42(62)14-13-41(61)55-19-17-54(18-20-55)28-40(60)52-16-5-3-2-4-15-51-36-8-6-7-30-43(36)47(66)58(46(30)65)37-11-12-39(59)53-44(37)63/h6-10,25-27,37,51H,2-5,11-24,28H2,1H3,(H,52,60)(H,53,59,63)","QHGGTIOQNUMWTN-UHFFFAOYSA-N"
"2982","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)NCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","796.064","794.142545056","4.09","54","6","9","3","10","174.53","C37H33Cl3N6O8","InChI=1S/C37H33Cl3N6O8/c1-54-29-19-26(40)23(22-17-20(38)5-6-25(22)39)18-24(29)35(51)45-15-13-44(14-16-45)32(49)10-9-30(47)42-12-11-41-27-4-2-3-21-33(27)37(53)46(36(21)52)28-7-8-31(48)43-34(28)50/h2-6,9-10,17-19,28,41H,7-8,11-16H2,1H3,(H,42,47)(H,43,48,50)/b10-9+","CURIXTMRQQABKR-MDZDMXLPSA-N"
"2983","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","810.091","808.15819512","4.44","55","6","9","3","11","174.53","C38H35Cl3N6O8","InChI=1S/C38H35Cl3N6O8/c1-55-30-20-27(41)24(23-18-21(39)6-7-26(23)40)19-25(30)36(52)46-16-14-45(15-17-46)33(50)11-10-31(48)43-13-3-12-42-28-5-2-4-22-34(28)38(54)47(37(22)53)29-8-9-32(49)44-35(29)51/h2,4-7,10-11,18-20,29,42H,3,8-9,12-17H2,1H3,(H,43,48)(H,44,49,51)/b11-10+","HSFNDKPUSTYBOY-ZHACJKMWSA-N"
"2984","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)NCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","824.118","822.173845184","4.8","56","6","9","3","12","174.53","C39H37Cl3N6O8","InChI=1S/C39H37Cl3N6O8/c1-56-31-21-28(42)25(24-19-22(40)7-8-27(24)41)20-26(31)37(53)47-17-15-46(16-18-47)34(51)12-11-32(49)44-14-3-2-13-43-29-6-4-5-23-35(29)39(55)48(38(23)54)30-9-10-33(50)45-36(30)52/h4-8,11-12,19-21,30,43H,2-3,9-10,13-18H2,1H3,(H,44,49)(H,45,50,52)/b12-11+","WECZQBSSBDBWRD-VAWYXSNFSA-N"
"2985","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1","1250/2500","","Degradation of KRAS G12C in NCI-H358/NCI-H23 cells after 48 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","17410","Inhibit proliferation of NCI-H358 cells","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","852.172","850.205145312","5.51","58","6","9","3","14","174.53","C41H41Cl3N6O8","InChI=1S/C41H41Cl3N6O8/c1-58-33-23-30(44)27(26-21-24(42)9-10-29(26)43)22-28(33)39(55)49-19-17-48(18-20-49)36(53)14-13-34(51)46-16-5-3-2-4-15-45-31-8-6-7-25-37(31)41(57)50(40(25)56)32-11-12-35(52)47-38(32)54/h6-10,13-14,21-23,32,45H,2-5,11-12,15-20H2,1H3,(H,46,51)(H,47,52,54)/b14-13+","LPVAFJZSEOPFFT-BUHFOSPRSA-N"
"2986","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)N2CCN(CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","922.223","920.221857996","3.43","63","7","11","3","12","198.08","C43H43Cl3N8O9","InChI=1S/C43H43Cl3N8O9/c1-63-34-23-31(46)28(27-21-25(44)5-6-30(27)45)22-29(34)41(60)53-19-17-52(18-20-53)38(58)10-9-37(57)51-15-13-50(14-16-51)24-36(56)48-12-11-47-32-4-2-3-26-39(32)43(62)54(42(26)61)33-7-8-35(55)49-40(33)59/h2-6,9-10,21-23,33,47H,7-8,11-20,24H2,1H3,(H,48,56)(H,49,55,59)/b10-9+","PRRUQEPFVMKYKC-MDZDMXLPSA-N"
"2987","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)N2CCN(CC(=O)NCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","936.25","934.23750806","3.78","64","7","11","3","13","198.08","C44H45Cl3N8O9","InChI=1S/C44H45Cl3N8O9/c1-64-35-24-32(47)29(28-22-26(45)6-7-31(28)46)23-30(35)42(61)54-20-18-53(19-21-54)39(59)11-10-38(58)52-16-14-51(15-17-52)25-37(57)49-13-3-12-48-33-5-2-4-27-40(33)44(63)55(43(27)62)34-8-9-36(56)50-41(34)60/h2,4-7,10-11,22-24,34,48H,3,8-9,12-21,25H2,1H3,(H,49,57)(H,50,56,60)/b11-10+","IZHURNUBUSBIPJ-ZHACJKMWSA-N"
"2988","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)N2CCN(CC(=O)NCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","950.277","948.253158124","4.14","65","7","11","3","14","198.08","C45H47Cl3N8O9","InChI=1S/C45H47Cl3N8O9/c1-65-36-25-33(48)30(29-23-27(46)7-8-32(29)47)24-31(36)43(62)55-21-19-54(20-22-55)40(60)12-11-39(59)53-17-15-52(16-18-53)26-38(58)50-14-3-2-13-49-34-6-4-5-28-41(34)45(64)56(44(28)63)35-9-10-37(57)51-42(35)61/h4-8,11-12,23-25,35,49H,2-3,9-10,13-22,26H2,1H3,(H,50,58)(H,51,57,61)/b12-11+","DKZYETVGNNHYKU-VAWYXSNFSA-N"
"2989","P01116","KRAS G12C","CRBN","","","COC1=CC(Cl)=C(C2=CC(Cl)=CC=C2Cl)C=C1C(=O)N1CCN(C(=O)/C=C/C(=O)N2CCN(CC(=O)NCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bioorg.2021.105447","978.331","976.284458252","4.85","67","7","11","3","16","198.08","C47H51Cl3N8O9","InChI=1S/C47H51Cl3N8O9/c1-67-38-27-35(50)32(31-25-29(48)9-10-34(31)49)26-33(38)45(64)57-23-21-56(22-24-57)42(62)14-13-41(61)55-19-17-54(18-20-55)28-40(60)52-16-5-3-2-4-15-51-36-8-6-7-30-43(36)47(66)58(46(30)65)37-11-12-39(59)53-44(37)63/h6-10,13-14,25-27,37,51H,2-5,11-12,15-24,28H2,1H3,(H,52,60)(H,53,59,63)/b14-13+","CJDBRSZWLJAXAP-BUHFOSPRSA-N"
"2990","Q06124","SHP2","CRBN","","","CC1(N)CCN(C2=CN=C(C3=CC=C(CCOCCOCCOCCOCCOCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C(Cl)=C3Cl)C(N)=N2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","929.856","928.328909908","1.35","64","6","16","4","24","249.09","C43H54Cl2N8O11","InChI=1S/C43H54Cl2N8O11/c1-43(47)10-13-52(14-11-43)32-25-49-38(39(46)50-32)29-6-5-27(36(44)37(29)45)9-15-59-17-19-61-21-23-63-24-22-62-20-18-60-16-12-48-34(55)26-64-31-4-2-3-28-35(31)42(58)53(41(28)57)30-7-8-33(54)51-40(30)56/h2-6,25,30H,7-24,26,47H2,1H3,(H2,46,50)(H,48,55)(H,51,54,56)","LJVCGCLJEMWQRB-UHFFFAOYSA-N"
"2991","Q06124","SHP2","CRBN","","","CC1(N)CCN(C2=CN=C(C3=CC(CCOCCOCCOCCOCCOCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)=CC(Cl)=C3Cl)C(N)=N2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","929.856","928.328909908","1.35","64","6","16","4","24","249.09","C43H54Cl2N8O11","InChI=1S/C43H54Cl2N8O11/c1-43(47)8-11-52(12-9-43)33-25-49-38(39(46)50-33)29-23-27(24-30(44)37(29)45)7-13-59-15-17-61-19-21-63-22-20-62-18-16-60-14-10-48-35(55)26-64-32-4-2-3-28-36(32)42(58)53(41(28)57)31-5-6-34(54)51-40(31)56/h2-4,23-25,31H,5-22,26,47H2,1H3,(H2,46,50)(H,48,55)(H,51,54,56)","YSWFEWKSNVSXPU-UHFFFAOYSA-N"
"2992","Q06124","SHP2","CRBN","","","CC1(N)CCN(C2=CN=C(C3=CC=C(OCCOCCOCCOCCOCCOCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C(Cl)=C3Cl)C(N)=N2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","945.855","944.323824528","1.06","65","6","17","4","25","258.32","C43H54Cl2N8O12","InChI=1S/C43H54Cl2N8O12/c1-43(47)9-12-52(13-10-43)32-25-49-38(39(46)50-32)28-5-7-31(37(45)36(28)44)64-24-23-63-22-21-62-20-19-61-18-17-60-16-15-59-14-11-48-34(55)26-65-30-4-2-3-27-35(30)42(58)53(41(27)57)29-6-8-33(54)51-40(29)56/h2-5,7,25,29H,6,8-24,26,47H2,1H3,(H2,46,50)(H,48,55)(H,51,54,56)","DBYYZBGGJACASU-UHFFFAOYSA-N"
"2993","Q06124","SHP2","CRBN","","","CC1(N)CCN(C2=CN=C(C3=CC(OCCOCCOCCOCCOCCOCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)=CC(Cl)=C3Cl)C(N)=N2)CC1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","945.855","944.323824528","1.06","65","6","17","4","25","258.32","C43H54Cl2N8O12","InChI=1S/C43H54Cl2N8O12/c1-43(47)7-10-52(11-8-43)33-25-49-38(39(46)50-33)29-23-27(24-30(44)37(29)45)64-22-21-63-20-19-62-18-17-61-16-15-60-14-13-59-12-9-48-35(55)26-65-32-4-2-3-28-36(32)42(58)53(41(28)57)31-5-6-34(54)51-40(31)56/h2-4,23-25,31H,5-22,26,47H2,1H3,(H2,46,50)(H,48,55)(H,51,54,56)","HLGUCGILFIUATA-UHFFFAOYSA-N"
"2994","Q06124","SHP2","CRBN","","","CC1=NC(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)=C(CO)N=C1C1=CC=C(OCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(Cl)=C1Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","942.851","941.312925496","1.24","65","7","16","4","20","243.3","C44H53Cl2N7O12","InChI=1S/C44H53Cl2N7O12/c1-25-38(50-29(22-54)40(49-25)52-13-10-44(11-14-52)24-65-26(2)39(44)47)28-6-8-32(37(46)36(28)45)63-21-20-62-19-18-61-17-16-60-15-12-48-34(56)23-64-31-5-3-4-27-35(31)43(59)53(42(27)58)30-7-9-33(55)51-41(30)57/h3-6,8,26,30,39,54H,7,9-24,47H2,1-2H3,(H,48,56)(H,51,55,57)/t26-,30?,39+/m0/s1","LYVPDXZNHNXRKZ-ASGCILDISA-N"
"2994","Q06124","SHP2 F285S","CRBN","","","CC1=NC(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)=C(CO)N=C1C1=CC=C(OCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(Cl)=C1Cl","","","","","","18.9","Inhibit the phosphatase activities of SHP2 F285S","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","942.851","941.312925496","1.24","65","7","16","4","20","243.3","C44H53Cl2N7O12","InChI=1S/C44H53Cl2N7O12/c1-25-38(50-29(22-54)40(49-25)52-13-10-44(11-14-52)24-65-26(2)39(44)47)28-6-8-32(37(46)36(28)45)63-21-20-62-19-18-61-17-16-60-15-12-48-34(56)23-64-31-5-3-4-27-35(31)43(59)53(42(27)58)30-7-9-33(55)51-41(30)57/h3-6,8,26,30,39,54H,7,9-24,47H2,1-2H3,(H,48,56)(H,51,55,57)/t26-,30?,39+/m0/s1","LYVPDXZNHNXRKZ-ASGCILDISA-N"
"2995","Q06124","SHP2","CRBN","","","CC1=NC(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)=C(CO)N=C1C1=CC=C(OCCOCCOCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(Cl)=C1Cl","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","1030.957","1029.36535499","0.94","71","7","18","4","26","261.76","C48H61Cl2N7O14","InChI=1S/C48H61Cl2N7O14/c1-29-42(54-33(26-58)44(53-29)56-13-10-48(11-14-56)28-71-30(2)43(48)51)32-6-8-36(41(50)40(32)49)69-25-24-68-23-22-67-21-20-66-19-18-65-17-16-64-15-12-52-38(60)27-70-35-5-3-4-31-39(35)47(63)57(46(31)62)34-7-9-37(59)55-45(34)61/h3-6,8,30,34,43,58H,7,9-28,51H2,1-2H3,(H,52,60)(H,55,59,61)/t30-,34?,43+/m0/s1","FKYAZLJUPCNHNB-XFGKOWHFSA-N"
"2995","Q06124","SHP2 F285S","CRBN","","","CC1=NC(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)=C(CO)N=C1C1=CC=C(OCCOCCOCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(Cl)=C1Cl","","","","","","14.1","Inhibit the phosphatase activities of SHP2 F285S","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","1030.957","1029.36535499","0.94","71","7","18","4","26","261.76","C48H61Cl2N7O14","InChI=1S/C48H61Cl2N7O14/c1-29-42(54-33(26-58)44(53-29)56-13-10-48(11-14-56)28-71-30(2)43(48)51)32-6-8-36(41(50)40(32)49)69-25-24-68-23-22-67-21-20-66-19-18-65-17-16-64-15-12-52-38(60)27-70-35-5-3-4-31-39(35)47(63)57(46(31)62)34-7-9-37(59)55-45(34)61/h3-6,8,30,34,43,58H,7,9-28,51H2,1-2H3,(H,52,60)(H,55,59,61)/t30-,34?,43+/m0/s1","FKYAZLJUPCNHNB-XFGKOWHFSA-N"
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"2996","Q06124","SHP2 F285S","CRBN","","","CC1=NC(N2CCC3(CC2)CO[C@@H](C)[C@H]3N)=C(CO)N=C1C1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(Cl)=C1Cl","","","","","","22.5","Inhibit the phosphatase activities of SHP2 F285S","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acs.biochem.1c00377","1119.063","1117.41778449","0.65","77","7","20","4","32","280.22","C52H69Cl2N7O16","InChI=1S/C52H69Cl2N7O16/c1-33-46(58-37(30-62)48(57-33)60-13-10-52(11-14-60)32-77-34(2)47(52)55)36-6-8-40(45(54)44(36)53)75-29-28-74-27-26-73-25-24-72-23-22-71-21-20-70-19-18-69-17-16-68-15-12-56-42(64)31-76-39-5-3-4-35-43(39)51(67)61(50(35)66)38-7-9-41(63)59-49(38)65/h3-6,8,34,38,47,62H,7,9-32,55H2,1-2H3,(H,56,64)(H,59,63,65)/t34-,38?,47+/m0/s1","HPTREZYMUUKMPI-VJYGXRPRSA-N"
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"3024","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOCC5C)=N4)C=C3)C(C)(C)C)C=C2)SC=N1",">10000","","Degradation of AR-V7 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","803.064","802.354625448","6.23","56","6","11","3","14","146.22","C42H54N6O6S2","InChI=1S/C42H54N6O6S2/c1-26-23-53-20-18-47(26)41-45-34(24-55-41)30-14-16-33(17-15-30)54-19-8-7-9-36(50)46-38(42(4,5)6)40(52)48-22-32(49)21-35(48)39(51)44-27(2)29-10-12-31(13-11-29)37-28(3)43-25-56-37/h10-17,24-27,32,35,38,49H,7-9,18-23H2,1-6H3,(H,44,51)(H,46,50)/t26?,27-,32+,35-,38+/m0/s1","UNSGLSMVFYYYDD-PCKHRFHFSA-N"
"3025","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CC(C)OC(C)C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","817.091","816.370275512","6.67","57","6","11","3","14","146.22","C43H56N6O6S2","InChI=1S/C43H56N6O6S2/c1-26-21-48(22-27(2)55-26)42-46-35(24-56-42)31-15-17-34(18-16-31)54-19-9-8-10-37(51)47-39(43(5,6)7)41(53)49-23-33(50)20-36(49)40(52)45-28(3)30-11-13-32(14-12-30)38-29(4)44-25-57-38/h11-18,24-28,33,36,39,50H,8-10,19-23H2,1-7H3,(H,45,52)(H,47,51)/t26?,27?,28-,33+,36-,39+/m0/s1","TVBMTILEYZGHOS-YOCVXMCCSA-N"
"3026","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CC(C)OCC5C)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","817.091","816.370275512","6.67","57","6","11","3","14","146.22","C43H56N6O6S2","InChI=1S/C43H56N6O6S2/c1-26-23-55-27(2)21-48(26)42-46-35(24-56-42)31-15-17-34(18-16-31)54-19-9-8-10-37(51)47-39(43(5,6)7)41(53)49-22-33(50)20-36(49)40(52)45-28(3)30-11-13-32(14-12-30)38-29(4)44-25-57-38/h11-18,24-28,33,36,39,50H,8-10,19-23H2,1-7H3,(H,45,52)(H,47,51)/t26?,27?,28-,33+,36-,39+/m0/s1","QFLAUKQPFRWZLW-YOCVXMCCSA-N"
"3027","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOC(C)(C)C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1",">10000","","Degradation of AR-V7 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","817.091","816.370275512","6.42","57","6","11","3","14","146.22","C43H56N6O6S2","InChI=1S/C43H56N6O6S2/c1-27(29-11-13-31(14-12-29)37-28(2)44-26-57-37)45-39(52)35-22-32(50)23-49(35)40(53)38(42(3,4)5)47-36(51)10-8-9-20-54-33-17-15-30(16-18-33)34-24-56-41(46-34)48-19-21-55-43(6,7)25-48/h11-18,24,26-27,32,35,38,50H,8-10,19-23,25H2,1-7H3,(H,45,52)(H,47,51)/t27-,32+,35-,38+/m0/s1","YIACDKDYDLPVNM-UTMFLMNVSA-N"
"3028","P10275","AR-V7","VHL","","","CCC1COCCN1C1=NC(C2=CC=C(OCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C=C2)=CS1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","817.091","816.370275512","6.76","57","6","11","3","15","146.22","C43H56N6O6S2","InChI=1S/C43H56N6O6S2/c1-7-32-24-54-21-19-48(32)42-46-35(25-56-42)30-15-17-34(18-16-30)55-20-9-8-10-37(51)47-39(43(4,5)6)41(53)49-23-33(50)22-36(49)40(52)45-27(2)29-11-13-31(14-12-29)38-28(3)44-26-57-38/h11-18,25-27,32-33,36,39,50H,7-10,19-24H2,1-6H3,(H,45,52)(H,47,51)/t27-,32?,33+,36-,39+/m0/s1","BVEYIQJQNDDACP-UBKFRZIOSA-N"
"3029","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CC6CCC(C5)O6)=N4)C=C3)C(C)(C)C)C=C2)SC=N1",">10000","","Degradation of AR-V7 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","815.075","814.354625448","6.42","57","7","11","3","14","146.22","C43H54N6O6S2","InChI=1S/C43H54N6O6S2/c1-26(28-9-11-30(12-10-28)38-27(2)44-25-57-38)45-40(52)36-20-31(50)21-49(36)41(53)39(43(3,4)5)47-37(51)8-6-7-19-54-32-15-13-29(14-16-32)35-24-56-42(46-35)48-22-33-17-18-34(23-48)55-33/h9-16,24-26,31,33-34,36,39,50H,6-8,17-23H2,1-5H3,(H,45,52)(H,47,51)/t26-,31+,33?,34?,36-,39+/m0/s1","VQDMQIVWDWRGNL-AEGWPRKASA-N"
"3030","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CC6(COC6)C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","801.048","800.338975384","5.69","56","7","11","3","14","146.22","C42H52N6O6S2","InChI=1S/C42H52N6O6S2/c1-26(28-9-11-30(12-10-28)36-27(2)43-25-56-36)44-38(51)34-18-31(49)19-48(34)39(52)37(41(3,4)5)46-35(50)8-6-7-17-54-32-15-13-29(14-16-32)33-20-55-40(45-33)47-21-42(22-47)23-53-24-42/h9-16,20,25-26,31,34,37,49H,6-8,17-19,21-24H2,1-5H3,(H,44,51)(H,46,50)/t26-,31+,34-,37+/m0/s1","HEXCMONMMZZNAC-ASCDMGAVSA-N"
"3031","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCC6(COC6)C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","815.075","814.354625448","6.05","57","7","11","3","14","146.22","C43H54N6O6S2","InChI=1S/C43H54N6O6S2/c1-27(29-9-11-31(12-10-29)37-28(2)44-26-57-37)45-39(52)35-20-32(50)21-49(35)40(53)38(42(3,4)5)47-36(51)8-6-7-19-55-33-15-13-30(14-16-33)34-22-56-41(46-34)48-18-17-43(23-48)24-54-25-43/h9-16,22,26-27,32,35,38,50H,6-8,17-21,23-25H2,1-5H3,(H,45,52)(H,47,51)/t27-,32+,35-,38+/m0/s1","VGEIWLKHGNCINB-UTMFLMNVSA-N"
"3032","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CC6(CCOCC6)C5)=N4)C=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","829.102","828.370275512","6.41","58","7","11","3","14","146.22","C44H56N6O6S2","InChI=1S/C44H56N6O6S2/c1-28(30-9-11-32(12-10-30)38-29(2)45-27-58-38)46-40(53)36-22-33(51)23-50(36)41(54)39(43(3,4)5)48-37(52)8-6-7-19-56-34-15-13-31(14-16-34)35-24-57-42(47-35)49-25-44(26-49)17-20-55-21-18-44/h9-16,24,27-28,33,36,39,51H,6-8,17-23,25-26H2,1-5H3,(H,46,53)(H,48,52)/t28-,33+,36-,39+/m0/s1","LRABJSWDQLGNSR-HYGIYIQXSA-N"
"3033","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOCC5)=N4)C=C3F)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","807.027","806.329553572","5.9","56","6","11","3","14","146.22","C41H51FN6O6S2","InChI=1S/C41H51FN6O6S2/c1-25(27-9-11-28(12-10-27)36-26(2)43-24-56-36)44-38(51)33-21-30(49)22-48(33)39(52)37(41(3,4)5)46-35(50)8-6-7-17-54-34-14-13-29(20-31(34)42)32-23-55-40(45-32)47-15-18-53-19-16-47/h9-14,20,23-25,30,33,37,49H,6-8,15-19,21-22H2,1-5H3,(H,44,51)(H,46,50)/t25-,30+,33-,37+/m0/s1","VQNFDTJKBKDGIZ-AYIFONRSSA-N"
"3034","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOCC5)=N4)C(F)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","807.027","806.329553572","5.9","56","6","11","3","14","146.22","C41H51FN6O6S2","InChI=1S/C41H51FN6O6S2/c1-25(27-9-11-28(12-10-27)36-26(2)43-24-56-36)44-38(51)34-20-29(49)22-48(34)39(52)37(41(3,4)5)46-35(50)8-6-7-17-54-30-13-14-31(32(42)21-30)33-23-55-40(45-33)47-15-18-53-19-16-47/h9-14,21,23-25,29,34,37,49H,6-8,15-20,22H2,1-5H3,(H,44,51)(H,46,50)/t25-,29+,34-,37+/m0/s1","VAIJCFLLVYDJDX-VWFFZPPBSA-N"
"3035","P10275","AR-V7","VHL","","","COC1=C(C2=CSC(N3CCOCC3)=N2)C=CC(OCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=C1F",">10000","","Degradation of AR-V7 in 22RV1 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","837.053","836.340118256","5.87","58","6","12","3","15","155.45","C42H53FN6O7S2","InChI=1S/C42H53FN6O7S2/c1-25(27-10-12-28(13-11-27)37-26(2)44-24-58-37)45-39(52)32-21-29(50)22-49(32)40(53)38(42(3,4)5)47-34(51)9-7-8-18-56-33-15-14-30(36(54-6)35(33)43)31-23-57-41(46-31)48-16-19-55-20-17-48/h10-15,23-25,29,32,38,50H,7-9,16-22H2,1-6H3,(H,45,52)(H,47,51)/t25-,29+,32-,38+/m0/s1","QDRLQXPFNAHLMJ-KBBXSPJUSA-N"
"3036","P10275","AR-V7","VHL","","","CC1=CC(OCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)=CC=C1C1=CSC(N2CCOCC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","803.064","802.354625448","6.17","56","6","11","3","14","146.22","C42H54N6O6S2","InChI=1S/C42H54N6O6S2/c1-26-21-32(14-15-33(26)34-24-55-41(45-34)47-16-19-53-20-17-47)54-18-8-7-9-36(50)46-38(42(4,5)6)40(52)48-23-31(49)22-35(48)39(51)44-27(2)29-10-12-30(13-11-29)37-28(3)43-25-56-37/h10-15,21,24-25,27,31,35,38,49H,7-9,16-20,22-23H2,1-6H3,(H,44,51)(H,46,50)/t27-,31+,35-,38+/m0/s1","OXMHDWGLRPFNFF-RBONMYIESA-N"
"3037","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOCC5)=N4)C=C3[N+](=O)[O-])C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","834.034","833.324053592","5.63","58","6","13","3","15","189.36","C41H51N7O8S2","InChI=1S/C41H51N7O8S2/c1-25(27-9-11-28(12-10-27)36-26(2)42-24-58-36)43-38(51)33-21-30(49)22-47(33)39(52)37(41(3,4)5)45-35(50)8-6-7-17-56-34-14-13-29(20-32(34)48(53)54)31-23-57-40(44-31)46-15-18-55-19-16-46/h9-14,20,23-25,30,33,37,49H,6-8,15-19,21-22H2,1-5H3,(H,43,51)(H,45,50)/t25-,30+,33-,37+/m0/s1","OBJVNPWHVXWQDQ-AYIFONRSSA-N"
"3038","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCOC3=CC=C(C4=CSC(N5CCOCC5)=N4)C=C3N)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","804.052","803.349874416","5.12","56","6","12","4","14","172.24","C41H53N7O6S2","InChI=1S/C41H53N7O6S2/c1-25(27-9-11-28(12-10-27)36-26(2)43-24-56-36)44-38(51)33-21-30(49)22-48(33)39(52)37(41(3,4)5)46-35(50)8-6-7-17-54-34-14-13-29(20-31(34)42)32-23-55-40(45-32)47-15-18-53-19-16-47/h9-14,20,23-25,30,33,37,49H,6-8,15-19,21-22,42H2,1-5H3,(H,44,51)(H,46,50)/t25-,30+,33-,37+/m0/s1","COHVKUGHNPBREF-AYIFONRSSA-N"
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"3041","P10275","AR-V7","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)C3(F)CC3)C(C)(C)C)C(OCCCCOC3=CC=C(C4=CSC(N5CCOCC5)=N4)C=C3)=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of 22Rv1 cells","","","","","","","","","","","","","10.1016/j.bmcl.2021.128448","849.064","848.340118256","6.16","59","7","12","3","16","155.45","C43H53FN6O7S2","InChI=1S/C43H53FN6O7S2/c1-27-36(59-26-46-27)29-7-8-30(23-45-38(52)34-22-31(51)24-50(34)39(53)37(42(2,3)4)48-40(54)43(44)13-14-43)35(21-29)57-18-6-5-17-56-32-11-9-28(10-12-32)33-25-58-41(47-33)49-15-19-55-20-16-49/h7-12,21,25-26,31,34,37,51H,5-6,13-20,22-24H2,1-4H3,(H,45,52)(H,48,54)/t31-,34+,37-/m1/s1","KVWNRPVGKCDOOA-WXEAQWFJSA-N"
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"3047","","FGFR3-TACC3","IAP","","SNIPER(TACC3)-11","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","995.286","994.455736452","7.35","70","7","16","5","26","210.92","C51H66N10O7S2","InChI=1S/C51H66N10O7S2/c1-33(2)29-55-43-19-20-54-51(59-43)56-30-39-31-69-48(57-39)37-17-15-36(16-18-37)47(64)53-21-23-66-24-25-67-26-27-68-40-13-8-12-38(28-40)45(62)41-32-70-49(58-41)42-14-9-22-61(42)50(65)44(35-10-6-5-7-11-35)60-46(63)34(3)52-4/h8,12-13,15-20,28,31-35,42,44,52H,5-7,9-11,14,21-27,29-30H2,1-4H3,(H,53,64)(H,60,63)(H2,54,55,56,59)/t34-,42-,44-/m0/s1","CTMIQTSKAZXRFZ-YSQZVTEJSA-N"
"3048","","FGFR3-TACC3","IAP","","SNIPER(TACC3)-12","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","1039.339","1038.4819512","7.21","73","7","17","5","29","220.15","C53H70N10O8S2","InChI=1S/C53H70N10O8S2/c1-35(2)31-57-45-19-20-56-53(61-45)58-32-41-33-72-50(59-41)39-17-15-38(16-18-39)49(66)55-21-23-68-24-25-69-26-27-70-28-29-71-42-13-8-12-40(30-42)47(64)43-34-73-51(60-43)44-14-9-22-63(44)52(67)46(37-10-6-5-7-11-37)62-48(65)36(3)54-4/h8,12-13,15-20,30,33-37,44,46,54H,5-7,9-11,14,21-29,31-32H2,1-4H3,(H,55,66)(H,62,65)(H2,56,57,58,61)/t36-,44-,46-/m0/s1","QZUDANDGKAWCMK-FMDQLCGKSA-N"
"3049","","FGFR3-TACC3","IAP","","SNIPER(TACC3)-13","CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C1=NC(C(=O)C2=CC=CC(OCCOCCOCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)=CS1)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","1083.392","1082.50816595","7.06","76","7","18","5","32","229.38","C55H74N10O9S2","InChI=1S/C55H74N10O9S2/c1-37(2)33-59-47-19-20-58-55(63-47)60-34-43-35-75-52(61-43)41-17-15-40(16-18-41)51(68)57-21-23-70-24-25-71-26-27-72-28-29-73-30-31-74-44-13-8-12-42(32-44)49(66)45-36-76-53(62-45)46-14-9-22-65(46)54(69)48(39-10-6-5-7-11-39)64-50(67)38(3)56-4/h8,12-13,15-20,32,35-39,46,48,56H,5-7,9-11,14,21-31,33-34H2,1-4H3,(H,57,68)(H,64,67)(H2,58,59,60,63)/t38-,46-,48-/m0/s1","APXQKGNOHLOXHN-XJBUIOPLSA-N"
"3050","","FGFR3-TACC3","XIAP","","SNIPER(TACC3)-14","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](OC2=CC=CC(OCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","1073.375","1072.55683039","8.12","77","8","15","6","27","219.29","C58H76N10O8S","InChI=1S/C58H76N10O8S/c1-38(2)34-62-51-24-25-61-58(66-51)63-35-44-37-77-56(64-44)43-22-20-42(21-23-43)54(70)60-26-27-73-28-29-74-30-31-75-45-16-11-17-46(32-45)76-47-33-50(55(71)65-49-19-10-15-40-12-8-9-18-48(40)49)68(36-47)57(72)52(41-13-6-5-7-14-41)67-53(69)39(3)59-4/h8-9,11-12,16-18,20-25,32,37-39,41,47,49-50,52,59H,5-7,10,13-15,19,26-31,33-36H2,1-4H3,(H,60,70)(H,65,71)(H,67,69)(H2,61,62,63,66)/t39-,47-,49+,50-,52-/m0/s1","QKJDMLXKICPSEL-OTSGRZTASA-N"
"3051","","FGFR3-TACC3","XIAP","","SNIPER(TACC3)-15","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](OC2=CC=CC(OCCOCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","1117.428","1116.58304514","7.97","80","8","16","6","30","228.52","C60H80N10O9S","InChI=1S/C60H80N10O9S/c1-40(2)36-64-53-24-25-63-60(68-53)65-37-46-39-80-58(66-46)45-22-20-44(21-23-45)56(72)62-26-27-75-28-29-76-30-31-77-32-33-78-47-16-11-17-48(34-47)79-49-35-52(57(73)67-51-19-10-15-42-12-8-9-18-50(42)51)70(38-49)59(74)54(43-13-6-5-7-14-43)69-55(71)41(3)61-4/h8-9,11-12,16-18,20-25,34,39-41,43,49,51-52,54,61H,5-7,10,13-15,19,26-33,35-38H2,1-4H3,(H,62,72)(H,67,73)(H,69,71)(H2,63,64,65,68)/t41-,49-,51+,52-,54-/m0/s1","KIWITWNEORBNBJ-FEUDWNBWSA-N"
"3052","","FGFR3-TACC3","XIAP","","SNIPER(TACC3)-16","CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](OC2=CC=CC(OCCOCCOCCOCCOCCNC(=O)C3=CC=C(C4=NC(CNC5=NC=CC(NCC(C)C)=N5)=CS4)C=C3)=C2)C[C@H]1C(=O)N[C@@H]1CCCC2=CC=CC=C21)C1CCCCC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.bmcl.2022.128584","1161.481","1160.60925989","7.82","83","8","17","6","33","237.75","C62H84N10O10S","InChI=1S/C62H84N10O10S/c1-42(2)38-66-55-24-25-65-62(70-55)67-39-48-41-83-60(68-48)47-22-20-46(21-23-47)58(74)64-26-27-77-28-29-78-30-31-79-32-33-80-34-35-81-49-16-11-17-50(36-49)82-51-37-54(59(75)69-53-19-10-15-44-12-8-9-18-52(44)53)72(40-51)61(76)56(45-13-6-5-7-14-45)71-57(73)43(3)63-4/h8-9,11-12,16-18,20-25,36,41-43,45,51,53-54,56,63H,5-7,10,13-15,19,26-35,37-40H2,1-4H3,(H,64,74)(H,69,75)(H,71,73)(H2,65,66,67,70)/t43-,51-,53+,54-,56-/m0/s1","UBVNASYNMAQCAT-GJFKRFNVSA-N"
"3053","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCC(CN5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7=O)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","788.349","787.324895252","4.89","57","9","9","1","6","137.37","C44H46ClN7O5","InChI=1S/C44H46ClN7O5/c1-27-21-44(26-51(27)34-7-4-30(22-46)37(45)20-34)12-16-49(17-13-44)33-5-2-29(3-6-33)41(55)50-14-10-28(11-15-50)23-48-24-31-18-35-36(19-32(31)25-48)43(57)52(42(35)56)38-8-9-39(53)47-40(38)54/h2-7,18-20,27-28,38H,8-17,21,23-26H2,1H3,(H,47,53,54)/t27-,38?/m0/s1","GAXWAKXJBZHVQF-ZVENJKCTSA-N"
"3054","P10275","AR","CRBN","","","CC1=C(N2CCC3(CCN(C4=CC=C(C(=O)N5CCC(N6CC7=CC8=C(C=C7C6)C(=O)N(C6CCC(=O)NC6=O)C8=O)CC5)C=C4)CC3)C2C)C=CC(C#N)=C1Cl","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","788.349","787.324895252","5.06","57","9","9","1","5","137.37","C44H46ClN7O5","InChI=1S/C44H46ClN7O5/c1-26-36(8-5-29(23-46)39(26)45)51-20-15-44(27(51)2)13-18-48(19-14-44)32-6-3-28(4-7-32)41(55)49-16-11-33(12-17-49)50-24-30-21-34-35(22-31(30)25-50)43(57)52(42(34)56)37-9-10-38(53)47-40(37)54/h3-8,21-22,27,33,37H,9-20,24-25H2,1-2H3,(H,47,53,54)","RWMQDUVHPMRHMV-UHFFFAOYSA-N"
"3055","P10275","AR","CRBN","","","CC1=C(N2CCC3(CCN(C4=CC=C(C(=O)N5CCC(CN6CC7=CC8=C(C=C7C6)C(=O)N(C6CCC(=O)NC6=O)C8=O)CC5)C=C4)CC3)C2C)C=CC(C#N)=C1Cl","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","802.376","801.340545316","5.25","58","9","9","1","6","137.37","C45H48ClN7O5","InChI=1S/C45H48ClN7O5/c1-27-37(8-5-31(23-47)40(27)46)52-20-15-45(28(52)2)13-18-50(19-14-45)34-6-3-30(4-7-34)42(56)51-16-11-29(12-17-51)24-49-25-32-21-35-36(22-33(32)26-49)44(58)53(43(35)57)38-9-10-39(54)48-41(38)55/h3-8,21-22,28-29,38H,9-20,24-26H2,1-2H3,(H,48,54,55)","REHRYTGOXHVITR-UHFFFAOYSA-N"
"3056","P10275","AR","CRBN","","","COC1(CN2CC3=CC4=C(C=C3C2)C(=O)N(C2CCC(=O)NC2=O)C4=O)CCN(C(=O)C2=CC=C(N3CCC4(CC3)C[C@H](C)N(C3=CC=C(C#N)C(Cl)=C3)C4)C=C2)CC1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","818.375","817.335459936","4.37","59","9","10","1","7","146.6","C45H48ClN7O6","InChI=1S/C45H48ClN7O6/c1-28-22-44(26-52(28)34-8-5-30(23-47)37(46)21-34)11-15-50(16-12-44)33-6-3-29(4-7-33)41(56)51-17-13-45(59-2,14-18-51)27-49-24-31-19-35-36(20-32(31)25-49)43(58)53(42(35)57)38-9-10-39(54)48-40(38)55/h3-8,19-21,28,38H,9-18,22,24-27H2,1-2H3,(H,48,54,55)/t28-,38?/m0/s1","MYAUGYDOTJZSSR-XRTOLJPQSA-N"
"3057","P10275","AR","CRBN","","","CC[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCC(N5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7=O)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","788.349","787.324895252","5.23","57","9","9","1","6","137.37","C44H46ClN7O5","InChI=1S/C44H46ClN7O5/c1-2-31-22-44(26-51(31)34-8-5-28(23-46)37(45)21-34)13-17-48(18-14-44)32-6-3-27(4-7-32)41(55)49-15-11-33(12-16-49)50-24-29-19-35-36(20-30(29)25-50)43(57)52(42(35)56)38-9-10-39(53)47-40(38)54/h3-8,19-21,31,33,38H,2,9-18,22,24-26H2,1H3,(H,47,53,54)/t31-,38?/m0/s1","BUZRUJXEBYATBA-LHSYUTFLSA-N"
"3058","P10275","AR","CRBN","","","CC[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCN(C5CN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)C5)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","803.364","802.335794284","5.04","58","9","10","1","7","140.61","C44H47ClN8O5","InChI=1S/C44H47ClN8O5/c1-2-30-23-44(27-52(30)33-8-5-29(24-46)37(45)22-33)13-15-48(16-14-44)31-6-3-28(4-7-31)41(56)50-19-17-49(18-20-50)34-25-51(26-34)32-9-10-35-36(21-32)43(58)53(42(35)57)38-11-12-39(54)47-40(38)55/h3-10,21-22,30,34,38H,2,11-20,23,25-27H2,1H3,(H,47,54,55)/t30-,38?/m0/s1","NEDWDSAZGZAIJE-VZSKUFKGSA-N"
"3059","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CC(CN5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7=O)C4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","760.295","759.293595124","4.18","55","9","9","1","6","137.37","C42H42ClN7O5","InChI=1S/C42H42ClN7O5/c1-25-17-42(24-49(25)32-7-4-28(18-44)35(43)16-32)10-12-47(13-11-42)31-5-2-27(3-6-31)39(53)48-20-26(21-48)19-46-22-29-14-33-34(15-30(29)23-46)41(55)50(40(33)54)36-8-9-37(51)45-38(36)52/h2-7,14-16,25-26,36H,8-13,17,19-24H2,1H3,(H,45,51,52)/t25-,36?/m0/s1","SIFVRCPVOMAZLY-XFCCSEHESA-N"
"3060","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCC(F)(CN5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","792.356","791.336208884","4.92","57","9","8","1","6","120.3","C44H47ClFN7O4","InChI=1S/C44H47ClFN7O4/c1-28-21-43(26-53(28)35-7-4-30(22-47)37(45)20-35)10-14-50(15-11-43)34-5-2-29(3-6-34)41(56)51-16-12-44(46,13-17-51)27-49-23-31-18-33-25-52(38-8-9-39(54)48-40(38)55)42(57)36(33)19-32(31)24-49/h2-7,18-20,28,38H,8-17,21,23-27H2,1H3,(H,48,54,55)/t28-,38?/m0/s1","NTPJLJWURIUSTB-XRTOLJPQSA-N"
"3061","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCC5(CC4)CC(N4CC6=CC7=C(C=C6C4)C(=O)N(C4CCC(=O)NC4=O)C7=O)C5)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=50/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","814.387","813.340545316","5.3","59","10","9","1","5","137.37","C46H48ClN7O5","InChI=1S/C46H48ClN7O5/c1-28-21-46(27-53(28)34-7-4-30(24-48)38(47)20-34)12-14-50(15-13-46)33-5-2-29(3-6-33)42(57)51-16-10-45(11-17-51)22-35(23-45)52-25-31-18-36-37(19-32(31)26-52)44(59)54(43(36)58)39-8-9-40(55)49-41(39)56/h2-7,18-20,28,35,39H,8-17,21-23,25-27H2,1H3,(H,49,55,56)/t28-,39?/m0/s1","JBTOLNXRVILBNA-RUITYDCOSA-N"
"3062","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCN(CC(=O)N5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7=O)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","817.347","816.31505884","3.45","59","9","10","1","6","157.68","C44H45ClN8O6","InChI=1S/C44H45ClN8O6/c1-27-21-44(26-52(27)33-7-4-29(22-46)36(45)20-33)10-12-49(13-11-44)32-5-2-28(3-6-32)41(57)50-16-14-48(15-17-50)25-39(55)51-23-30-18-34-35(19-31(30)24-51)43(59)53(42(34)58)37-8-9-38(54)47-40(37)56/h2-7,18-20,27,37H,8-17,21,23-26H2,1H3,(H,47,54,56)/t27-,37?/m0/s1","RQIBYZFBWNLMBH-YTCZSSRZSA-N"
"3063","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCN(C(=O)CN5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7=O)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","817.347","816.31505884","3.45","59","9","10","1","6","157.68","C44H45ClN8O6","InChI=1S/C44H45ClN8O6/c1-27-21-44(26-52(27)33-7-4-29(22-46)36(45)20-33)10-12-49(13-11-44)32-5-2-28(3-6-32)41(57)51-16-14-50(15-17-51)39(55)25-48-23-30-18-34-35(19-31(30)24-48)43(59)53(42(34)58)37-8-9-38(54)47-40(37)56/h2-7,18-20,27,37H,8-17,21,23-26H2,1H3,(H,47,54,56)/t27-,37?/m0/s1","HVRQFVOFOCEMCC-YTCZSSRZSA-N"
"3064","P10275","AR","CRBN","","","C[C@H]1CC2(CCN(C3=CC=C(C(=O)N4CCN(C(=O)CN5CC6=CC7=C(C=C6C5)C(=O)N(C5CCC(=O)NC5=O)C7)CC4)C=C3)CC2)CN1C1=CC=C(C#N)C(Cl)=C1","","","",">=90/>=90","% AR degradation in Vcap cells after 24 h treatment at 10/100 nM","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00498","803.364","802.335794284","3.5","58","9","9","1","6","140.61","C44H47ClN8O5","InChI=1S/C44H47ClN8O5/c1-28-21-44(27-53(28)35-7-4-30(22-46)37(45)20-35)10-12-49(13-11-44)34-5-2-29(3-6-34)42(57)51-16-14-50(15-17-51)40(55)26-48-23-31-18-33-25-52(38-8-9-39(54)47-41(38)56)43(58)36(33)19-32(31)24-48/h2-7,18-20,28,38H,8-17,21,23-27H2,1H3,(H,47,54,56)/t28-,38?/m0/s1","KDYZCAPPIPJMJT-XRTOLJPQSA-N"
"3065","P51617","IRAK1","VHL","","","COC1=CC(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","16","95","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","864.042","863.378866036","4.63","62","7","12","5","14","204.0","C45H53N9O7S","InChI=1S/C45H53N9O7S/c1-27-40(62-26-47-27)29-11-9-28(10-12-29)23-46-43(58)37-22-31(55)24-54(37)44(59)41(45(2,3)4)51-39(56)25-61-32-16-19-53(20-17-32)30-13-14-35(38(21-30)60-5)50-42(57)36-8-6-7-33(49-36)34-15-18-48-52-34/h6-15,18,21,26,31-32,37,41,55H,16-17,19-20,22-25H2,1-5H3,(H,46,58)(H,48,52)(H,50,57)(H,51,56)/t31-,37+,41-/m1/s1","PWCLOPMRUGHLET-SPVIJIGUSA-N"
"3066","P51617","IRAK1","VHL","","","COC1=CC(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","3","96","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","878.069","877.3945161","5.03","63","7","12","5","14","204.0","C46H55N9O7S","InChI=1S/C46H55N9O7S/c1-27(29-10-12-30(13-11-29)41-28(2)47-26-63-41)49-44(59)38-23-32(56)24-55(38)45(60)42(46(3,4)5)52-40(57)25-62-33-17-20-54(21-18-33)31-14-15-36(39(22-31)61-6)51-43(58)37-9-7-8-34(50-37)35-16-19-48-53-35/h7-16,19,22,26-27,32-33,38,42,56H,17-18,20-21,23-25H2,1-6H3,(H,48,53)(H,49,59)(H,51,58)(H,52,57)/t27-,32+,38-,42+/m0/s1","MHRNVFQJUUXQIG-VIFUUBRESA-N"
"3067","P51617","IRAK1","VHL","","","COC1=CC(N2CCN(C(=O)OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","16","97","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","893.04","892.369029624","3.9","64","7","13","5","13","224.31","C45H52N10O8S","InChI=1S/C45H52N10O8S/c1-27-39(64-26-47-27)29-11-9-28(10-12-29)23-46-42(59)36-22-31(56)24-55(36)43(60)40(45(2,3)4)51-38(57)25-63-44(61)54-19-17-53(18-20-54)30-13-14-34(37(21-30)62-5)50-41(58)35-8-6-7-32(49-35)33-15-16-48-52-33/h6-16,21,26,31,36,40,56H,17-20,22-25H2,1-5H3,(H,46,59)(H,48,52)(H,50,58)(H,51,57)/t31-,36+,40-/m1/s1","GGEHXEZNDKXJIX-OXGRJUKFSA-N"
"3068","P51617","IRAK1","VHL","","","COC1=CC(N2CCN(C(=O)OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)CC2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","9","90","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","907.067","906.384679688","4.3","65","7","13","5","13","224.31","C46H54N10O8S","InChI=1S/C46H54N10O8S/c1-27(29-10-12-30(13-11-29)40-28(2)47-26-65-40)49-43(60)37-23-32(57)24-56(37)44(61)41(46(3,4)5)52-39(58)25-64-45(62)55-20-18-54(19-21-55)31-14-15-35(38(22-31)63-6)51-42(59)36-9-7-8-33(50-36)34-16-17-48-53-34/h7-17,22,26-27,32,37,41,57H,18-21,23-25H2,1-6H3,(H,48,53)(H,49,60)(H,51,59)(H,52,58)/t27-,32+,37-,41+/m0/s1","MWQAAQOVPMFJQP-KTOUKBDOSA-N"
"3069","P51617","IRAK1","VHL","","","COC1=CC(N2CCC(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3F)C(C)(C)C)CC2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","13","96","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","882.032","881.369444224","4.73","63","7","12","5","14","204.0","C45H52FN9O7S","InChI=1S/C45H52FN9O7S/c1-26-40(63-25-48-26)27-9-10-28(32(46)19-27)22-47-43(59)37-21-30(56)23-55(37)44(60)41(45(2,3)4)52-39(57)24-62-31-14-17-54(18-15-31)29-11-12-35(38(20-29)61-5)51-42(58)36-8-6-7-33(50-36)34-13-16-49-53-34/h6-13,16,19-20,25,30-31,37,41,56H,14-15,17-18,21-24H2,1-5H3,(H,47,59)(H,49,53)(H,51,58)(H,52,57)/t30-,37+,41-/m1/s1","NEMQBDGIUBMFBU-UAFBGOENSA-N"
"3070","P51617","IRAK1","VHL","","","COC1=CC(N2CC[C@@H](OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)C[C@@H]2C)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","13","94","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","892.096","891.410166164","5.46","64","7","12","5","14","204.0","C47H57N9O7S","InChI=1S/C47H57N9O7S/c1-27-21-34(18-20-55(27)32-15-16-37(40(22-32)62-7)52-44(59)38-10-8-9-35(51-38)36-17-19-49-54-36)63-25-41(58)53-43(47(4,5)6)46(61)56-24-33(57)23-39(56)45(60)50-28(2)30-11-13-31(14-12-30)42-29(3)48-26-64-42/h8-17,19,22,26-28,33-34,39,43,57H,18,20-21,23-25H2,1-7H3,(H,49,54)(H,50,60)(H,52,59)(H,53,58)/t27-,28-,33+,34+,39-,43+/m0/s1","ITIRIVDRAPMHII-LHJQLXEHSA-N"
"3071","P51617","IRAK1","VHL","","","COC1=CC(N2CC[C@@H](OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)[C@H](C)C2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","21","96","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","892.096","891.410166164","5.46","64","7","12","5","14","204.0","C47H57N9O7S","InChI=1S/C47H57N9O7S/c1-27-23-55(32-15-16-36(40(21-32)62-7)52-44(59)37-10-8-9-34(51-37)35-17-19-49-54-35)20-18-39(27)63-25-41(58)53-43(47(4,5)6)46(61)56-24-33(57)22-38(56)45(60)50-28(2)30-11-13-31(14-12-30)42-29(3)48-26-64-42/h8-17,19,21,26-28,33,38-39,43,57H,18,20,22-25H2,1-7H3,(H,49,54)(H,50,60)(H,52,59)(H,53,58)/t27-,28+,33-,38+,39-,43-/m1/s1","GHFASOYKYKNVGE-YLSOEQEJSA-N"
"3072","P51617","IRAK1","VHL","","","COC1=CC(N2CC[C@H](OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)C3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)[C@@H](C)C2)=CC=C1NC(=O)C1=CC=CC(C2=CC=N[NH]2)=N1","","95","Degradation of IRAK1 in HEK293T cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00244","892.096","891.410166164","5.46","64","7","12","5","14","204.0","C47H57N9O7S","InChI=1S/C47H57N9O7S/c1-27-23-55(32-15-16-36(40(21-32)62-7)52-44(59)37-10-8-9-34(51-37)35-17-19-49-54-35)20-18-39(27)63-25-41(58)53-43(47(4,5)6)46(61)56-24-33(57)22-38(56)45(60)50-28(2)30-11-13-31(14-12-30)42-29(3)48-26-64-42/h8-17,19,21,26-28,33,38-39,43,57H,18,20,22-25H2,1-7H3,(H,49,54)(H,50,60)(H,52,59)(H,53,58)/t27-,28-,33+,38-,39-,43+/m0/s1","GHFASOYKYKNVGE-QSQOCCPDSA-N"
"3073","O60674","JAK2","CRBN","","SJ000988497","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.2","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","688.749","688.287014252","3.76","51","7","11","5","13","196.1","C36H36N10O5","InChI=1S/C36H36N10O5/c1-2-18-45-20-22(19-40-45)30-25-14-17-38-31(25)44-36(43-30)41-23-10-8-21(9-11-23)32(48)39-16-4-3-15-37-26-7-5-6-24-29(26)35(51)46(34(24)50)27-12-13-28(47)42-33(27)49/h5-11,14,17,19-20,27,37H,2-4,12-13,15-16,18H2,1H3,(H,39,48)(H,42,47,49)(H2,38,41,43,44)","MPFPDTOOHBZQJD-UHFFFAOYSA-N"
"3074","O60674","JAK2","CRBN","","SJ000986420","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCCCCC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","673.778","673.312500728","4.09","50","7","9","4","13","167.0","C37H39N9O4","InChI=1S/C37H39N9O4/c1-2-19-45-21-25(20-40-45)32-28-16-18-38-33(28)44-37(43-32)41-26-12-10-24(11-13-26)34(48)39-17-5-3-4-7-23-8-6-9-27-29(23)22-46(36(27)50)30-14-15-31(47)42-35(30)49/h6,8-13,16,18,20-21,30H,2-5,7,14-15,17,19,22H2,1H3,(H,39,48)(H,42,47,49)(H2,38,41,43,44)","YJQZQVOPZCTYQO-UHFFFAOYSA-N"
"3075","O60674","JAK2","CRBN","","SJ000988500","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.7","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","716.803","716.31831438","4.48","53","7","11","5","15","196.1","C38H40N10O5","InChI=1S/C38H40N10O5/c1-2-20-47-22-24(21-42-47)32-27-16-19-40-33(27)46-38(45-32)43-25-12-10-23(11-13-25)34(50)41-18-6-4-3-5-17-39-28-9-7-8-26-31(28)37(53)48(36(26)52)29-14-15-30(49)44-35(29)51/h7-13,16,19,21-22,29,39H,2-6,14-15,17-18,20H2,1H3,(H,41,50)(H,44,49,51)(H2,40,43,45,46)","JKVWQNULVWSWIV-UHFFFAOYSA-N"
"3076","O60674","JAK2","CRBN","","SJ000988498","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.5","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","674.722","674.271364188","3.41","50","7","11","5","12","196.1","C35H34N10O5","InChI=1S/C35H34N10O5/c1-2-17-44-19-21(18-39-44)29-24-13-16-37-30(24)43-35(42-29)40-22-9-7-20(8-10-22)31(47)38-15-4-14-36-25-6-3-5-23-28(25)34(50)45(33(23)49)26-11-12-27(46)41-32(26)48/h3,5-10,13,16,18-19,26,36H,2,4,11-12,14-15,17H2,1H3,(H,38,47)(H,41,46,48)(H2,37,40,42,43)","DEVPPEULDFALCD-UHFFFAOYSA-N"
"3077","O60674","JAK2","CRBN","","SJ000988499","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCCCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","0.9","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","702.776","702.302664316","4.12","52","7","11","5","14","196.1","C37H38N10O5","InChI=1S/C37H38N10O5/c1-2-19-46-21-23(20-41-46)31-26-15-18-39-32(26)45-37(44-31)42-24-11-9-22(10-12-24)33(49)40-17-5-3-4-16-38-27-8-6-7-25-30(27)36(52)47(35(25)51)28-13-14-29(48)43-34(28)50/h6-12,15,18,20-21,28,38H,2-5,13-14,16-17,19H2,1H3,(H,40,49)(H,43,48,50)(H2,39,42,44,45)","IIQDLBHJZXCCRN-UHFFFAOYSA-N"
"3078","O60674","JAK2","CRBN","","SJ000986340","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","15","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","704.748","704.281928872","2.9","52","7","12","5","14","205.33","C36H36N10O6","InChI=1S/C36H36N10O6/c1-2-16-45-20-22(19-40-45)30-25-12-13-38-31(25)44-36(43-30)41-23-8-6-21(7-9-23)32(48)39-15-18-52-17-14-37-26-5-3-4-24-29(26)35(51)46(34(24)50)27-10-11-28(47)42-33(27)49/h3-9,12-13,19-20,27,37H,2,10-11,14-18H2,1H3,(H,39,48)(H,42,47,49)(H2,38,41,43,44)","JRAOUSBLDNFFPC-UHFFFAOYSA-N"
"3079","O60674","JAK2","CRBN","","SJ000986050","CCCN1C=C(C2=NC(NC3=CC=C(C(=O)NCCOCCOCCOCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)C=C3)=NC3=C2C=C[NH]3)C=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","720","Inhibit proliferation of MHH-CALL-4 cells","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00245","925.013","924.413002612","2.17","67","7","17","5","29","251.48","C46H56N10O11","InChI=1S/C46H56N10O11/c1-2-16-55-30-32(29-50-55)40-35-12-13-48-41(35)54-46(53-40)51-33-8-6-31(7-9-33)42(58)49-15-18-63-20-22-65-24-26-67-28-27-66-25-23-64-21-19-62-17-14-47-36-5-3-4-34-39(36)45(61)56(44(34)60)37-10-11-38(57)52-43(37)59/h3-9,12-13,29-30,37,47H,2,10-11,14-28H2,1H3,(H,49,58)(H,52,57,59)(H2,48,51,53,54)","DHNZVZVXOQVZJE-UHFFFAOYSA-N"
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"3092","Q06187","BTK","CRBN","","","NC(=O)C1=C2NCC[C@@H](C3CCN(C(=O)CCC4CCC(N5CCN(C6=CC=C7C(=O)N(C8CCC(=O)NC8=O)C(=O)C7=C6)CC5)CC4)CC3)N2N=C1C1=CC=C(OC2=CC=CC=C2)C=C1","17","","Degradation of BTK in Ramos cells after 16 h treatment by ELISA assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00178","896.062","895.438095164","4.61","66","10","12","3","11","192.51","C50H57N9O7","InChI=1S/C50H57N9O7/c51-46(62)44-45(33-9-14-37(15-10-33)66-36-4-2-1-3-5-36)54-59-40(20-23-52-47(44)59)32-21-24-57(25-22-32)43(61)19-8-31-6-11-34(12-7-31)55-26-28-56(29-27-55)35-13-16-38-39(30-35)50(65)58(49(38)64)41-17-18-42(60)53-48(41)63/h1-5,9-10,13-16,30-32,34,40-41,52H,6-8,11-12,17-29H2,(H2,51,62)(H,53,60,63)/t31?,34?,40-,41?/m0/s1","GIDSHQNPQLLDGD-VHPJZFMFSA-N"
"3093","Q06187","BTK","CRBN","","","NC(=O)C1=C2NCC[C@@H](C3CCN(C(=O)CCCN4CCN(C(=O)CNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)N2N=C1C1=CC=C(OC2=CC=CC=C2)C=C1","35","","Degradation of BTK in Ramos cells after 16 h treatment by ELISA assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00178","884.995","884.396958624","2.47","65","9","13","4","13","221.61","C47H52N10O8","InChI=1S/C47H52N10O8/c48-43(61)41-42(30-8-11-33(12-9-30)65-32-5-2-1-3-6-32)52-57-36(16-19-49-44(41)57)29-17-21-54(22-18-29)39(59)7-4-20-53-23-25-55(26-24-53)40(60)28-50-31-10-13-34-35(27-31)47(64)56(46(34)63)37-14-15-38(58)51-45(37)62/h1-3,5-6,8-13,27,29,36-37,49-50H,4,7,14-26,28H2,(H2,48,61)(H,51,58,62)/t36-,37?/m0/s1","ZRHRJLMEFZTXRX-NWDJCJOJSA-N"
"3094","Q06187","BTK","CRBN","","","CN(CC1CCN(C(=O)C2=CC=C(N3CCC(=O)NC3=O)C=C2)CC1)C1CC(C(=O)N2CCC([C@@H]3CCNC4=C(C(N)=O)C(C5=CC=C(OC6=CC=CC=C6)C=C5)=NN43)CC2)C1","7.2","","Degradation of BTK in Ramos cells after 16 h treatment by ELISA assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00178","842.014","841.42753048","4.1","62","9","10","3","11","175.44","C47H55N9O6","InChI=1S/C47H55N9O6/c1-52(29-30-16-22-53(23-17-30)45(59)33-7-11-35(12-8-33)55-26-20-40(57)50-47(55)61)36-27-34(28-36)46(60)54-24-18-31(19-25-54)39-15-21-49-44-41(43(48)58)42(51-56(39)44)32-9-13-38(14-10-32)62-37-5-3-2-4-6-37/h2-14,30-31,34,36,39,49H,15-29H2,1H3,(H2,48,58)(H,50,57,61)/t34?,36?,39-/m0/s1","JCHKKGUWOQWSRJ-MOGPQGRSSA-N"
"3095","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C(C)=C2C)=CC(OC)=C1CCN1CCC(OC2CCN(C(=O)C3=CC=C(Cl)C(N4CCC(=O)NC4=O)=C3)CC2)CC1","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","734.294","733.324226556","3.52","52","6","9","1","10","122.65","C39H48ClN5O7","InChI=1S/C39H48ClN5O7/c1-24-25(2)37(47)42(3)23-31(24)27-21-34(50-4)30(35(22-27)51-5)12-16-43-14-8-28(9-15-43)52-29-10-17-44(18-11-29)38(48)26-6-7-32(40)33(20-26)45-19-13-36(46)41-39(45)49/h6-7,20-23,28-29H,8-19H2,1-5H3,(H,41,46,49)","DBQTXWRLCKDYPJ-UHFFFAOYSA-N"
"3096","Q9H8M2","BRD9","CRBN","","","COC1=CC(C2=CN(C)C(=O)C3=CN=CC=C23)=CC(OC)=C1CCN1CCC(OC2CCN(C(=O)C3=CC=C(Cl)C(N4CCC(=O)NC4=O)=C3)CC2)CC1","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","757.288","756.30382546","3.29","54","7","10","1","10","135.54","C40H45ClN6O7","InChI=1S/C40H45ClN6O7/c1-44-24-32(29-6-13-42-23-31(29)39(44)50)26-21-35(52-2)30(36(22-26)53-3)11-16-45-14-7-27(8-15-45)54-28-9-17-46(18-10-28)38(49)25-4-5-33(41)34(20-25)47-19-12-37(48)43-40(47)51/h4-6,13,20-24,27-28H,7-12,14-19H2,1-3H3,(H,43,48,51)","QCZROHALGMEVOV-UHFFFAOYSA-N"
"3097","Q9H8M2","BRD9","CRBN","","","CCCCN1C=C(C2=CC=C(OC3CCN(CC4CCN(C(=O)C5=CC=C(Cl)C(N6CCC(=O)NC6=O)=C5)CC4)CC3)C(OC)=C2)C2=CC=NC=C2C1=O","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","755.316","754.324560904","4.61","54","7","9","1","11","126.31","C41H47ClN6O6","InChI=1S/C41H47ClN6O6/c1-3-4-16-47-26-33(31-9-15-43-24-32(31)40(47)51)28-6-8-36(37(23-28)53-2)54-30-12-17-45(18-13-30)25-27-10-19-46(20-11-27)39(50)29-5-7-34(42)35(22-29)48-21-14-38(49)44-41(48)52/h5-9,15,22-24,26-27,30H,3-4,10-14,16-21,25H2,1-2H3,(H,44,49,52)","MQXFOTNUITWXQX-UHFFFAOYSA-N"
"3098","Q9H8M2","BRD9","CRBN","","","CCCCN1C=C(C2=CC(OC)=C(OC3CCN(CC4CCN(C(=O)C5=CC=C(Cl)C(N6CCC(=O)NC6=O)=C5)CC4)CC3)C(OC)=C2)C2=CC=NC=C2C1=O","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","785.342","784.335125588","4.59","56","7","10","1","12","135.54","C42H49ClN6O7","InChI=1S/C42H49ClN6O7/c1-4-5-15-48-26-33(31-8-14-44-24-32(31)41(48)52)29-22-36(54-2)39(37(23-29)55-3)56-30-11-16-46(17-12-30)25-27-9-18-47(19-10-27)40(51)28-6-7-34(43)35(21-28)49-20-13-38(50)45-42(49)53/h6-8,14,21-24,26-27,30H,4-5,9-13,15-20,25H2,1-3H3,(H,45,50,53)","XGYWVYJNKZAZLG-UHFFFAOYSA-N"
"3099","Q9H8M2","BRD9","CRBN","","","CCCCN1C=C(C2=CC=C(O[C@H]3CCN(CC4CCN(C(=O)C5=CC=C(OC)C(N6CCC(=O)NC6=O)=C5)CC4)C[C@@H]3F)C(OC)=C2)C2=CC=NC=C2C1=O","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","768.887","768.364676128","4.01","56","7","10","1","12","135.54","C42H49FN6O7","InChI=1S/C42H49FN6O7/c1-4-5-16-48-25-32(30-10-15-44-23-31(30)41(48)52)28-6-9-37(38(22-28)55-3)56-35-13-17-46(26-33(35)43)24-27-11-18-47(19-12-27)40(51)29-7-8-36(54-2)34(21-29)49-20-14-39(50)45-42(49)53/h6-10,15,21-23,25,27,33,35H,4-5,11-14,16-20,24,26H2,1-3H3,(H,45,50,53)/t33-,35-/m0/s1","RHYLAIPZKCALML-LRHLLKFHSA-N"
"3100","Q9H8M2","BRD9","CRBN","","","CCCCN1C=C(C2=CC(F)=C(O[C@H]3CCN(CC4CCN(C(=O)C5=CC=C(OC)C(N6CCC(=O)NC6=O)=C5)CC4)C[C@@H]3F)C(F)=C2)C2=CC=NC=C2C1=O","1","","Degradation of BRD9 in HEK293A cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00580","774.841","774.33526782","4.24","56","7","9","1","11","126.31","C41H45F3N6O6","InChI=1S/C41H45F3N6O6/c1-3-4-13-49-23-30(28-7-12-45-21-29(28)40(49)53)27-18-31(42)38(32(43)19-27)56-35-10-14-47(24-33(35)44)22-25-8-15-48(16-9-25)39(52)26-5-6-36(55-2)34(20-26)50-17-11-37(51)46-41(50)54/h5-7,12,18-21,23,25,33,35H,3-4,8-11,13-17,22,24H2,1-2H3,(H,46,51,54)/t33-,35-/m0/s1","WJKOYUQUWSPEDI-LRHLLKFHSA-N"
"3101","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC=CC=C2O)C=C1N1CCN(C2=CC=CC(CN3CCN(C(=O)C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)CC3)=C2)C2(CC2)C1","4","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","838.97","838.39147932","2.48","62","10","13","3","8","188.85","C46H50N10O6","InChI=1S/C46H50N10O6/c47-41-38(26-36(49-50-41)34-6-1-2-7-39(34)57)54-22-23-55(46(28-54)14-15-46)32-5-3-4-29(24-32)27-51-18-20-53(21-19-51)43(60)30-12-16-52(17-13-30)31-8-9-33-35(25-31)45(62)56(44(33)61)37-10-11-40(58)48-42(37)59/h1-9,24-26,30,37,57H,10-23,27-28H2,(H2,47,50)(H,48,58,59)","QCCHVYRUHHHVFL-UHFFFAOYSA-N"
"3102","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC=CC=C2O)C=C1N1CC2CCC(C1)N2C1=CC=CC(OCCN2CCN(CC3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)=C1","2","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","855.013","854.422779448","3.73","63","10","14","3","11","181.01","C47H54N10O6","InChI=1S/C47H54N10O6/c48-44-41(26-39(50-51-44)37-6-1-2-7-42(37)58)55-28-33-8-9-34(29-55)56(33)32-4-3-5-35(24-32)63-23-22-52-18-20-53(21-19-52)27-30-14-16-54(17-15-30)31-10-11-36-38(25-31)47(62)57(46(36)61)40-12-13-43(59)49-45(40)60/h1-7,10-11,24-26,30,33-34,40,58H,8-9,12-23,27-29H2,(H2,48,51)(H,49,59,60)","NZXFUHUZHUMMLU-UHFFFAOYSA-N"
"3103","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC=CC=C2O)C=C1N1CC2CCC(C1)N2C1=CC=CC(OCCN2CCN(CCCC3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)=C1","2","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","883.067","882.454079576","4.44","65","10","14","3","13","181.01","C49H58N10O6","InChI=1S/C49H58N10O6/c50-46-43(29-41(52-53-46)39-8-1-2-9-44(39)60)57-30-35-10-11-36(31-57)58(35)34-6-3-7-37(27-34)65-26-25-55-23-21-54(22-24-55)18-4-5-32-16-19-56(20-17-32)33-12-13-38-40(28-33)49(64)59(48(38)63)42-14-15-45(61)51-47(42)62/h1-3,6-9,12-13,27-29,32,35-36,42,60H,4-5,10-11,14-26,30-31H2,(H2,50,53)(H,51,61,62)","UTLOUOROEIRWIF-UHFFFAOYSA-N"
"3104","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC=CC=C2O)C=C1N1CC(OC2=CC=CC(CN3CCN(C(=O)CN4CCC(C5=CC=C(NC6CCC(=O)NC6=O)C=C5)CC4)CC3)=C2)C1","3","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","759.912","759.385665668","3.06","56","8","12","4","11","169.49","C42H49N9O5","InChI=1S/C42H49N9O5/c43-41-37(23-36(46-47-41)34-6-1-2-7-38(34)52)51-25-33(26-51)56-32-5-3-4-28(22-32)24-49-18-20-50(21-19-49)40(54)27-48-16-14-30(15-17-48)29-8-10-31(11-9-29)44-35-12-13-39(53)45-42(35)55/h1-11,22-23,30,33,35,44,52H,12-21,24-27H2,(H2,43,47)(H,45,53,55)","VVNYHGLUTRJGFK-UHFFFAOYSA-N"
"3105","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC(F)=CC=C2O)C=C1N1CC2CCC(C1)N2C1=CC=CC(CN2CCN(C(=O)C3CCN(C4=CC=C5C(=O)N(C6CCC(=O)NC6=O)C(=O)C5=C4)CC3)CC2)=C1","3","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","856.96","856.382057508","2.83","63","10","13","3","8","188.85","C46H49FN10O6","InChI=1S/C46H49FN10O6/c47-29-4-10-40(58)36(21-29)37-23-39(42(48)51-50-37)55-25-32-5-6-33(26-55)56(32)31-3-1-2-27(20-31)24-52-16-18-54(19-17-52)44(61)28-12-14-53(15-13-28)30-7-8-34-35(22-30)46(63)57(45(34)62)38-9-11-41(59)49-43(38)60/h1-4,7-8,10,20-23,28,32-33,38,58H,5-6,9,11-19,24-26H2,(H2,48,51)(H,49,59,60)","JDTSERWCVQGCFT-UHFFFAOYSA-N"
"3106","P51531","SMARCA2","CRBN","","","NC1=NN=C(C2=CC=CC=C2O)C=C1N1CCC(C(=O)N2CCC(C(=O)N3CCN(C4=CC=C(C5CCC(=O)NC5=O)C=C4)CC3)CC2)(C2=CC=CC=C2)CC1","3","","Degradation of SMARCA2 HiBiT in HT1080 cells after 6 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00657","756.908","756.374766636","3.0","56","8","10","3","7","165.3","C43H48N8O5","InChI=1S/C43H48N8O5/c44-39-36(28-35(46-47-39)34-8-4-5-9-37(34)52)49-22-18-43(19-23-49,31-6-2-1-3-7-31)42(56)51-20-16-30(17-21-51)41(55)50-26-24-48(25-27-50)32-12-10-29(11-13-32)33-14-15-38(53)45-40(33)54/h1-13,28,30,33,52H,14-27H2,(H2,44,47)(H,45,53,54)","GPZCDIKIONXKJM-UHFFFAOYSA-N"
"3107","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(C(=O)CCCNC6=CC=CC7=C6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)N=C4)C=C23)=C1F","26","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","896.934","896.287585744","3.11","64","8","12","4","14","227.18","C43H42F2N10O8S","InChI=1S/C43H42F2N10O8S/c1-3-52(2)64(62,63)51-31-11-10-29(44)37(38(31)45)39(58)28-23-49-40-27(28)20-25(22-48-40)24-9-13-33(47-21-24)53-16-18-54(19-17-53)35(57)8-5-15-46-30-7-4-6-26-36(30)43(61)55(42(26)60)32-12-14-34(56)50-41(32)59/h4,6-7,9-11,13,20-23,32,46,51H,3,5,8,12,14-19H2,1-2H3,(H,48,49)(H,50,56,59)","IDIDGUPJKXQFDW-UHFFFAOYSA-N"
"3108","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(C(=O)[C@H]6C[C@H](NC7=CC=CC8=C7C(=O)N(C7CCC(=O)NC7=O)C8=O)C6)CC5)N=C4)C=C23)=C1F","10","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","908.945","908.287585744","2.79","65","9","12","4","12","227.18","C44H42F2N10O8S","InChI=1S/C44H42F2N10O8S/c1-3-53(2)65(63,64)52-32-9-8-30(45)37(38(32)46)39(58)29-22-49-40-28(29)19-25(21-48-40)23-7-11-34(47-20-23)54-13-15-55(16-14-54)42(60)24-17-26(18-24)50-31-6-4-5-27-36(31)44(62)56(43(27)61)33-10-12-35(57)51-41(33)59/h4-9,11,19-22,24,26,33,50,52H,3,10,12-18H2,1-2H3,(H,48,49)(H,51,57,59)/t24-,26-,33?","ODASMJWPZUAEOH-KBOGUJPVSA-N"
"3109","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(C(=O)CCCOC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)N=C4)C=C23)=C1F","10","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","883.935","883.292336776","2.6","63","8","11","3","14","207.31","C43H43F2N9O8S","InChI=1S/C43H43F2N9O8S/c1-3-51(2)63(60,61)50-32-11-10-31(44)38(39(32)45)40(57)29-23-48-41-28(29)20-26(22-47-41)25-9-13-35(46-21-25)52-15-17-53(18-16-52)37(56)8-5-19-62-34-7-4-6-27-30(34)24-54(43(27)59)33-12-14-36(55)49-42(33)58/h4,6-7,9-11,13,20-23,33,50H,3,5,8,12,14-19,24H2,1-2H3,(H,47,48)(H,49,55,58)","XDLVFGNNSKLZTE-UHFFFAOYSA-N"
"3110","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CN=C(N5CCN(C(=O)CCCOC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)N=C4)C=C23)=C1F","20","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","884.923","884.287585744","1.95","63","8","12","3","14","220.2","C42H42F2N10O8S","InChI=1S/C42H42F2N10O8S/c1-3-51(2)63(60,61)50-31-10-9-30(43)36(37(31)44)38(57)28-22-46-39-27(28)18-24(19-45-39)25-20-47-42(48-21-25)53-15-13-52(14-16-53)35(56)8-5-17-62-33-7-4-6-26-29(33)23-54(41(26)59)32-11-12-34(55)49-40(32)58/h4,6-7,9-10,18-22,32,50H,3,5,8,11-17,23H2,1-2H3,(H,45,46)(H,49,55,58)","FOPROWALTSOUAU-UHFFFAOYSA-N"
"3111","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(C(=O)[C@H]6C[C@H](NC7=CC=CC8=C7C(=O)N(C7CCC(=O)NC7=O)C8=O)C6)CC5)C=C4)C=C23)=C1F","23","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","907.957","907.292336776","3.52","65","9","11","4","12","214.29","C45H43F2N9O8S","InChI=1S/C45H43F2N9O8S/c1-3-53(2)65(63,64)52-34-12-11-32(46)38(39(34)47)40(58)31-23-49-41-30(31)21-26(22-48-41)24-7-9-28(10-8-24)54-15-17-55(18-16-54)43(60)25-19-27(20-25)50-33-6-4-5-29-37(33)45(62)56(44(29)61)35-13-14-36(57)51-42(35)59/h4-12,21-23,25,27,35,50,52H,3,13-20H2,1-2H3,(H,48,49)(H,51,57,59)/t25-,27-,35?","DFAPPDJMTAQYIX-KDDZAWODSA-N"
"3112","P15056","BRAF V600E","CRBN","","","CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=C[NH]C3=NC=C(C4=CC=C(N5CCN(C(=O)CCCOC6=CC=CC7=C6CN(C6CCC(=O)NC6=O)C7=O)CC5)C=C4)C=C23)=C1F","16","","Degradation of BRAF V600E in A375 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.2c00039","882.947","882.297087808","3.33","63","8","10","3","14","194.42","C44H44F2N8O8S","InChI=1S/C44H44F2N8O8S/c1-3-51(2)63(60,61)50-34-14-13-33(45)39(40(34)46)41(57)31-24-48-42-30(31)22-27(23-47-42)26-9-11-28(12-10-26)52-17-19-53(20-18-52)38(56)8-5-21-62-36-7-4-6-29-32(36)25-54(44(29)59)35-15-16-37(55)49-43(35)58/h4,6-7,9-14,22-24,35,50H,3,5,8,15-21,25H2,1-2H3,(H,47,48)(H,49,55,58)","LSJXTQQYRIMOFI-UHFFFAOYSA-N"
"3113","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CCCCCCCCCN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","10000","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11000/11000/9700","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1283.371","1280.56826402","17.14","89","10","8","0","20","96.76","C73H88Cl4N8O4","InChI=1S/C73H88Cl4N8O4/c1-9-88-62-48-54(72(3,4)5)26-36-60(62)68-78-64(50-18-28-56(74)29-19-50)66(52-22-32-58(76)33-23-52)84(68)70(86)82-44-40-80(41-45-82)38-16-14-12-11-13-15-17-39-81-42-46-83(47-43-81)71(87)85-67(53-24-34-59(77)35-25-53)65(51-20-30-57(75)31-21-51)79-69(85)61-37-27-55(73(6,7)8)49-63(61)89-10-2/h18-37,48-49,64-67H,9-17,38-47H2,1-8H3","FJYPHYQQWFXCAD-UHFFFAOYSA-N"
"3114","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCCCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","650","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2100/1500/2500","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1283.283","1280.495493","14.13","89","10","8","0","16","130.9","C71H80Cl4N8O6","InChI=1S/C71H80Cl4N8O6/c1-9-88-58-44-50(70(3,4)5)24-34-56(58)66-76-62(46-16-26-52(72)27-17-46)64(48-20-30-54(74)31-21-48)82(66)68(86)80-40-36-78(37-41-80)60(84)14-12-11-13-15-61(85)79-38-42-81(43-39-79)69(87)83-65(49-22-32-55(75)33-23-49)63(47-18-28-53(73)29-19-47)77-67(83)57-35-25-51(71(6,7)8)45-59(57)89-10-2/h16-35,44-45,62-65H,9-15,36-43H2,1-8H3","BACZXBTVFQSYNP-UHFFFAOYSA-N"
"3115","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCCCCCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","1600","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6300/3800/5700","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1311.337","1308.52679313","15.22","91","10","8","0","18","130.9","C73H84Cl4N8O6","InChI=1S/C73H84Cl4N8O6/c1-9-90-60-46-52(72(3,4)5)26-36-58(60)68-78-64(48-18-28-54(74)29-19-48)66(50-22-32-56(76)33-23-50)84(68)70(88)82-42-38-80(39-43-82)62(86)16-14-12-11-13-15-17-63(87)81-40-44-83(45-41-81)71(89)85-67(51-24-34-57(77)35-25-51)65(49-20-30-55(75)31-21-49)79-69(85)59-37-27-53(73(6,7)8)47-61(59)91-10-2/h18-37,46-47,64-67H,9-17,38-45H2,1-8H3","LBRFHVSZCYCUID-UHFFFAOYSA-N"
"3116","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCCCCCCCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","26000","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">50000/>50000/>50000","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1339.391","1336.55809326","16.3","93","10","8","0","20","130.9","C75H88Cl4N8O6","InChI=1S/C75H88Cl4N8O6/c1-9-92-62-48-54(74(3,4)5)28-38-60(62)70-80-66(50-20-30-56(76)31-21-50)68(52-24-34-58(78)35-25-52)86(70)72(90)84-44-40-82(41-45-84)64(88)18-16-14-12-11-13-15-17-19-65(89)83-42-46-85(47-43-83)73(91)87-69(53-26-36-59(79)37-27-53)67(51-22-32-57(77)33-23-51)81-71(87)61-39-29-55(75(6,7)8)49-63(61)93-10-2/h20-39,48-49,66-69H,9-19,40-47H2,1-8H3","WSUJRDLWWFUCNH-UHFFFAOYSA-N"
"3117","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)CCCCCCCCCCCCCCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","39000","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">50000/>50000/>50000","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1409.526","1406.63634358","19.01","98","10","8","0","25","130.9","C80H98Cl4N8O6","InChI=1S/C80H98Cl4N8O6/c1-9-97-67-53-59(79(3,4)5)33-43-65(67)75-85-71(55-25-35-61(81)36-26-55)73(57-29-39-63(83)40-30-57)91(75)77(95)89-49-45-87(46-50-89)69(93)23-21-19-17-15-13-11-12-14-16-18-20-22-24-70(94)88-47-51-90(52-48-88)78(96)92-74(58-31-41-64(84)42-32-58)72(56-27-37-62(82)38-28-56)86-76(92)66-44-34-60(80(6,7)8)54-68(66)98-10-2/h25-44,53-54,71-74H,9-24,45-52H2,1-8H3","JVLOQYYFORFYJJ-UHFFFAOYSA-N"
"3118","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)COCCOCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","1500","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6600/4600/3900","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1301.254","1298.46967218","12.78","90","10","10","0","17","149.36","C70H78Cl4N8O8","InChI=1S/C70H78Cl4N8O8/c1-9-89-57-41-49(69(3,4)5)19-29-55(57)65-75-61(45-11-21-51(71)22-12-45)63(47-15-25-53(73)26-16-47)81(65)67(85)79-35-31-77(32-36-79)59(83)43-87-39-40-88-44-60(84)78-33-37-80(38-34-78)68(86)82-64(48-17-27-54(74)28-18-48)62(46-13-23-52(72)24-14-46)76-66(82)56-30-20-50(70(6,7)8)42-58(56)90-10-2/h11-30,41-42,61-64H,9-10,31-40,43-44H2,1-8H3","ZXGIBUVTGMPOBQ-UHFFFAOYSA-N"
"3119","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(C(=O)COCCOCCOCC(=O)N2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2)CC1","","","","","","","","","","","","220","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1300/1200/1300","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1345.307","1342.49588692","12.63","93","10","11","0","20","158.59","C72H82Cl4N8O9","InChI=1S/C72H82Cl4N8O9/c1-9-92-59-43-51(71(3,4)5)19-29-57(59)67-77-63(47-11-21-53(73)22-12-47)65(49-15-25-55(75)26-16-49)83(67)69(87)81-35-31-79(32-36-81)61(85)45-90-41-39-89-40-42-91-46-62(86)80-33-37-82(38-34-80)70(88)84-66(50-17-27-56(76)28-18-50)64(48-13-23-54(74)24-14-48)78-68(84)58-30-20-52(72(6,7)8)44-60(58)93-10-2/h11-30,43-44,63-66H,9-10,31-42,45-46H2,1-8H3","KJMZIYWOELEOSP-UHFFFAOYSA-N"
"3120","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","1010",">95","Degradation of MDM2 in A549 cells after 24 h treatment","","","","","","","","","100","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1000/3300/1900","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","0.06","Compounds were administered at 10000 nM and incubated for 2 h","0.02","Compounds were administered at 10000 nM and incubated for 2 h","10.1016/j.apsb.2020.11.022","1459.411","1456.53881436","11.32","101","10","13","2","26","216.79","C76H88Cl4N10O11","InChI=1S/C76H88Cl4N10O11/c1-9-100-61-43-53(75(3,4)5)19-29-59(61)71-83-67(49-11-21-55(77)22-12-49)69(51-15-25-57(79)26-16-51)89(71)73(95)87-35-33-85(65(93)47-87)45-63(91)81-31-37-97-39-41-99-42-40-98-38-32-82-64(92)46-86-34-36-88(48-66(86)94)74(96)90-70(52-17-27-58(80)28-18-52)68(50-13-23-56(78)24-14-50)84-72(90)60-30-20-54(76(6,7)8)44-62(60)101-10-2/h11-30,43-44,67-70H,9-10,31-42,45-48H2,1-8H3,(H,81,91)(H,82,92)","BYXQFJDQDXLTHH-UHFFFAOYSA-N"
"3121","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","","","","","","","","","","","","1800","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","6600/7300/3900","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1415.358","1412.51259961","11.47","98","10","12","2","23","207.56","C74H84Cl4N10O10","InChI=1S/C74H84Cl4N10O10/c1-9-97-59-41-51(73(3,4)5)19-29-57(59)69-81-65(47-11-21-53(75)22-12-47)67(49-15-25-55(77)26-16-49)87(69)71(93)85-35-33-83(63(91)45-85)43-61(89)79-31-37-95-39-40-96-38-32-80-62(90)44-84-34-36-86(46-64(84)92)72(94)88-68(50-17-27-56(78)28-18-50)66(48-13-23-54(76)24-14-48)82-70(88)58-30-20-52(74(6,7)8)42-60(58)98-10-2/h11-30,41-42,65-68H,9-10,31-40,43-46H2,1-8H3,(H,79,89)(H,80,90)","UOZWQNRVMXKLGM-UHFFFAOYSA-N"
"3122","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=NC(C2=CC=C(Cl)C=C2)C(C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=NC(C4=CC=C(Cl)C=C4)C3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","","","","","","","","","","","","1200","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","9300/12000/7400","Inhibit proliferation of A549/HepG2/HCT116 cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1371.305","1368.48638486","11.62","95","10","11","2","20","198.33","C72H80Cl4N10O9","InChI=1S/C72H80Cl4N10O9/c1-9-94-57-39-49(71(3,4)5)19-29-55(57)67-79-63(45-11-21-51(73)22-12-45)65(47-15-25-53(75)26-16-47)85(67)69(91)83-35-33-81(61(89)43-83)41-59(87)77-31-37-93-38-32-78-60(88)42-82-34-36-84(44-62(82)90)70(92)86-66(48-17-27-54(76)28-18-48)64(46-13-23-52(74)24-14-46)80-68(86)56-30-20-50(72(6,7)8)40-58(56)95-10-2/h11-30,39-40,63-66H,9-10,31-38,41-44H2,1-8H3,(H,77,87)(H,78,88)","GLMOUWLKYKBYER-UHFFFAOYSA-N"
"3123","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@@H](C2=CC=C(Cl)C=C2)[C@@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=N[C@@H](C4=CC=C(Cl)C=C4)[C@H]3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","","","","","","","","","","","","90","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","580/1100/21000","Inhibit proliferation of A549/HCT116 (P53+)/HCT116 (P53-) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1459.411","1456.53881436","11.32","101","10","13","2","26","216.79","C76H88Cl4N10O11","InChI=1S/C76H88Cl4N10O11/c1-9-100-61-43-53(75(3,4)5)19-29-59(61)71-83-67(49-11-21-55(77)22-12-49)69(51-15-25-57(79)26-16-51)89(71)73(95)87-35-33-85(65(93)47-87)45-63(91)81-31-37-97-39-41-99-42-40-98-38-32-82-64(92)46-86-34-36-88(48-66(86)94)74(96)90-70(52-17-27-58(80)28-18-52)68(50-13-23-56(78)24-14-50)84-72(90)60-30-20-54(76(6,7)8)44-62(60)101-10-2/h11-30,43-44,67-70H,9-10,31-42,45-48H2,1-8H3,(H,81,91)(H,82,92)/t67-,68-,69+,70+/m0/s1","BYXQFJDQDXLTHH-IJGXWXDRSA-N"
"3124","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@H](C2=CC=C(Cl)C=C2)[C@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=N[C@H](C4=CC=C(Cl)C=C4)[C@@H]3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","","","","","","","","","","","","120","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","8300/9900/>50000","Inhibit proliferation of A549/HCT116 (P53+)/HCT116 (P53-) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1459.411","1456.53881436","11.32","101","10","13","2","26","216.79","C76H88Cl4N10O11","InChI=1S/C76H88Cl4N10O11/c1-9-100-61-43-53(75(3,4)5)19-29-59(61)71-83-67(49-11-21-55(77)22-12-49)69(51-15-25-57(79)26-16-51)89(71)73(95)87-35-33-85(65(93)47-87)45-63(91)81-31-37-97-39-41-99-42-40-98-38-32-82-64(92)46-86-34-36-88(48-66(86)94)74(96)90-70(52-17-27-58(80)28-18-52)68(50-13-23-56(78)24-14-50)84-72(90)60-30-20-54(76(6,7)8)44-62(60)101-10-2/h11-30,43-44,67-70H,9-10,31-42,45-48H2,1-8H3,(H,81,91)(H,82,92)/t67-,68-,69+,70+/m1/s1","BYXQFJDQDXLTHH-PQMVWXROSA-N"
"3125","Q00987","MDM2","MDM2","","","CCOC1=CC(C(C)(C)C)=CC=C1C1=N[C@H](C2=CC=C(Cl)C=C2)[C@H](C2=CC=C(Cl)C=C2)N1C(=O)N1CCN(CC(=O)NCCOCCOCCOCCNC(=O)CN2CCN(C(=O)N3C(C4=CC=C(C(C)(C)C)C=C4OCC)=N[C@@H](C4=CC=C(Cl)C=C4)[C@H]3C3=CC=C(Cl)C=C3)CC2=O)C(=O)C1","","","","","","","","","","","","9900","MDM2-P53 competitive binding activities were tested by FP","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11000/8700/>50000","Inhibit proliferation of A549/HCT116 (P53+)/HCT116 (P53-) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.022","1459.411","1456.53881436","11.32","101","10","13","2","26","216.79","C76H88Cl4N10O11","InChI=1S/C76H88Cl4N10O11/c1-9-100-61-43-53(75(3,4)5)19-29-59(61)71-83-67(49-11-21-55(77)22-12-49)69(51-15-25-57(79)26-16-51)89(71)73(95)87-35-33-85(65(93)47-87)45-63(91)81-31-37-97-39-41-99-42-40-98-38-32-82-64(92)46-86-34-36-88(48-66(86)94)74(96)90-70(52-17-27-58(80)28-18-52)68(50-13-23-56(78)24-14-50)84-72(90)60-30-20-54(76(6,7)8)44-62(60)101-10-2/h11-30,43-44,67-70H,9-10,31-42,45-48H2,1-8H3,(H,81,91)(H,82,92)/t67-,68+,69+,70-","BYXQFJDQDXLTHH-JMEZDKBESA-N"
"3126","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.9/10/83.2","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","933.945","933.342144092","3.83","68","8","12","4","15","208.26","C48H46F3N9O8","InChI=1S/C48H46F3N9O8/c1-29-5-7-32(24-31(29)8-6-30-23-34-27-53-57-43(34)52-26-30)44(63)54-35-10-9-33(37(25-35)48(49,50)51)28-59-16-14-58(15-17-59)18-20-68-22-21-67-19-13-41(62)55-38-4-2-3-36-42(38)47(66)60(46(36)65)39-11-12-40(61)56-45(39)64/h2-5,7,9-10,23-27,39H,11-22,28H2,1H3,(H,54,63)(H,55,62)(H,52,53,57)(H,56,61,64)","PFRHPQIDIMACRD-UHFFFAOYSA-N"
"3127","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCC(=O)NC4=CC=CC5=C4CN(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4/65.3/286.9","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","919.962","919.362879536","3.34","67","8","11","4","15","191.19","C48H48F3N9O7","InChI=1S/C48H48F3N9O7/c1-30-5-7-33(24-32(30)8-6-31-23-35-27-53-57-44(35)52-26-31)45(63)54-36-10-9-34(39(25-36)48(49,50)51)28-59-16-14-58(15-17-59)18-20-67-22-21-66-19-13-43(62)55-40-4-2-3-37-38(40)29-60(47(37)65)41-11-12-42(61)56-46(41)64/h2-5,7,9-10,23-27,41H,11-22,28-29H2,1H3,(H,54,63)(H,55,62)(H,52,53,57)(H,56,61,64)","IHTIJAFBJCXRSX-UHFFFAOYSA-N"
"3128","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCOC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.2/22.4/212.2","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","906.919","906.33124506","4.14","66","8","12","3","15","188.39","C47H45F3N8O8","InChI=1S/C47H45F3N8O8/c1-29-5-7-32(24-31(29)8-6-30-23-34-27-52-55-42(34)51-26-30)43(60)53-35-10-9-33(37(25-35)47(48,49)50)28-57-15-13-56(14-16-57)17-18-64-19-20-65-21-22-66-39-4-2-3-36-41(39)46(63)58(45(36)62)38-11-12-40(59)54-44(38)61/h2-5,7,9-10,23-27,38H,11-22,28H2,1H3,(H,53,60)(H,51,52,55)(H,54,59,61)","JDKFZPNYYIACBJ-UHFFFAOYSA-N"
"3129","","BCR-ABL T315I","VHL","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCC(=O)N[C@H](C(=O)C4C[C@H](O)C[C@H]4C(=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4)C(C)(C)C)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","31/336.6/981.2","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","1090.283","1089.47580111","6.74","78","8","13","5","20","204.0","C58H66F3N9O7S","InChI=1S/C58H66F3N9O7S/c1-36-6-10-42(27-41(36)13-9-39-26-44-33-65-68-54(44)62-32-39)55(74)66-45-15-14-43(49(28-45)58(59,60)61)34-70-19-17-69(18-20-70)21-23-77-25-24-76-22-16-50(72)67-53(57(3,4)5)51(73)47-29-46(71)30-48(47)56(75)63-31-38-7-11-40(12-8-38)52-37(2)64-35-78-52/h6-8,10-12,14-15,26-28,32-33,35,46-48,53,71H,16-25,29-31,34H2,1-5H3,(H,63,75)(H,66,74)(H,67,72)(H,62,65,68)/t46-,47?,48+,53+/m0/s1","VYBCUOUSYNHOCT-SKDLHVORSA-N"
"3130","","BCR-ABL T315I","cIAP1","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CC4=CC=CC=C4)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","58.6/240.4/2313","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","940.081","939.4618653","5.12","68","6","11","6","21","200.06","C50H60F3N9O6","InChI=1S/C50H60F3N9O6/c1-33(2)25-44(59-49(66)45(63)43(54)27-35-7-5-4-6-8-35)48(65)55-15-21-67-23-24-68-22-20-61-16-18-62(19-17-61)32-39-13-14-41(29-42(39)50(51,52)53)58-47(64)38-11-9-34(3)37(28-38)12-10-36-26-40-31-57-60-46(40)56-30-36/h4-9,11,13-14,26,28-31,33,43-45,63H,15-25,27,32,54H2,1-3H3,(H,55,65)(H,58,64)(H,59,66)(H,56,57,60)/t43-,44+,45+/m1/s1","SXFFGCVXIXJIGA-YFDFPCLUSA-N"
"3131","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3.5/20.7/67.5","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","889.892","889.315929344","3.98","65","8","11","4","12","199.03","C46H42F3N9O7","InChI=1S/C46H42F3N9O7/c1-27-5-7-30(22-29(27)8-6-28-21-32-25-51-55-41(32)50-24-28)42(61)52-33-10-9-31(35(23-33)46(47,48)49)26-57-16-14-56(15-17-57)18-20-65-19-13-39(60)53-36-4-2-3-34-40(36)45(64)58(44(34)63)37-11-12-38(59)54-43(37)62/h2-5,7,9-10,21-25,37H,11-20,26H2,1H3,(H,52,61)(H,53,60)(H,50,51,55)(H,54,59,62)","ZNIHRYIHPJCGLB-UHFFFAOYSA-N"
"3132","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","13.7/10.6/83.4","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","977.998","977.36835884","3.69","71","8","13","4","18","217.49","C50H50F3N9O9","InChI=1S/C50H50F3N9O9/c1-31-5-7-34(26-33(31)8-6-32-25-36-29-55-59-45(36)54-28-32)46(65)56-37-10-9-35(39(27-37)50(51,52)53)30-61-16-14-60(15-17-61)18-20-70-22-24-71-23-21-69-19-13-43(64)57-40-4-2-3-38-44(40)49(68)62(48(38)67)41-11-12-42(63)58-47(41)66/h2-5,7,9-10,25-29,41H,11-24,30H2,1H3,(H,56,65)(H,57,64)(H,54,55,59)(H,58,63,66)","KJWOKZPRDWMRID-UHFFFAOYSA-N"
"3133","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCOCCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","11.4/19.9/95.4","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","1022.051","1021.39457359","3.54","74","8","14","4","21","226.72","C52H54F3N9O10","InChI=1S/C52H54F3N9O10/c1-33-5-7-36(28-35(33)8-6-34-27-38-31-57-61-47(38)56-30-34)48(67)58-39-10-9-37(41(29-39)52(53,54)55)32-63-16-14-62(15-17-63)18-20-72-22-24-74-26-25-73-23-21-71-19-13-45(66)59-42-4-2-3-40-46(42)51(70)64(50(40)69)43-11-12-44(65)60-49(43)68/h2-5,7,9-10,27-31,43H,11-26,32H2,1H3,(H,58,67)(H,59,66)(H,56,57,61)(H,60,65,68)","MVYXUKMBIDMYOK-UHFFFAOYSA-N"
"3134","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCOCCOCCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.8/14.3/60.1","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","1066.104","1065.42078834","3.39","77","8","15","4","24","235.95","C54H58F3N9O11","InChI=1S/C54H58F3N9O11/c1-35-5-7-38(30-37(35)8-6-36-29-40-33-59-63-49(40)58-32-36)50(69)60-41-10-9-39(43(31-41)54(55,56)57)34-65-16-14-64(15-17-65)18-20-74-22-24-76-26-28-77-27-25-75-23-21-73-19-13-47(68)61-44-4-2-3-42-48(44)53(72)66(52(42)71)45-11-12-46(67)62-51(45)70/h2-5,7,9-10,29-33,45H,11-28,34H2,1H3,(H,60,69)(H,61,68)(H,58,59,63)(H,62,67,70)","XQMIQKPKGJLISR-UHFFFAOYSA-N"
"3135","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCOCCOCCOCCOCCOCCOCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.5/107/305.6","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","1110.157","1109.44700308","3.24","80","8","16","4","27","245.18","C56H62F3N9O12","InChI=1S/C56H62F3N9O12/c1-37-5-7-40(32-39(37)8-6-38-31-42-35-61-65-51(42)60-34-38)52(71)62-43-10-9-41(45(33-43)56(57,58)59)36-67-16-14-66(15-17-67)18-20-76-22-24-78-26-28-80-30-29-79-27-25-77-23-21-75-19-13-49(70)63-46-4-2-3-44-50(46)55(74)68(54(44)73)47-11-12-48(69)64-53(47)72/h2-5,7,9-10,31-35,47H,11-30,36H2,1H3,(H,62,71)(H,63,70)(H,60,61,65)(H,64,69,72)","AFTDBLZDDYJQMW-UHFFFAOYSA-N"
"3136","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.1/5.4/65.8","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","845.839","845.289714596","4.13","62","8","10","4","9","189.8","C44H38F3N9O6","InChI=1S/C44H38F3N9O6/c1-25-5-7-28(20-27(25)8-6-26-19-30-23-49-53-39(30)48-22-26)40(59)50-31-10-9-29(33(21-31)44(45,46)47)24-55-17-15-54(16-18-55)14-13-37(58)51-34-4-2-3-32-38(34)43(62)56(42(32)61)35-11-12-36(57)52-41(35)60/h2-5,7,9-10,19-23,35H,11-18,24H2,1H3,(H,50,59)(H,51,58)(H,48,49,53)(H,52,57,60)","LPQZQNDLJAVQDT-UHFFFAOYSA-N"
"3137","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","3/4.3/25","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","873.893","873.321014724","4.84","64","8","10","4","11","189.8","C46H42F3N9O6","InChI=1S/C46H42F3N9O6/c1-27-8-10-30(22-29(27)11-9-28-21-32-25-51-55-41(32)50-24-28)42(61)52-33-13-12-31(35(23-33)46(47,48)49)26-57-19-17-56(18-20-57)16-3-2-7-38(59)53-36-6-4-5-34-40(36)45(64)58(44(34)63)37-14-15-39(60)54-43(37)62/h4-6,8,10,12-13,21-25,37H,2-3,7,14-20,26H2,1H3,(H,52,61)(H,53,59)(H,50,51,55)(H,54,60,62)","RFRQZAIAFBCVHU-UHFFFAOYSA-N"
"3138","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2.1/4.2/33.4","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","887.92","887.336664788","5.2","65","8","10","4","12","189.8","C47H44F3N9O6","InChI=1S/C47H44F3N9O6/c1-28-9-11-31(23-30(28)12-10-29-22-33-26-52-56-42(33)51-25-29)43(62)53-34-14-13-32(36(24-34)47(48,49)50)27-58-20-18-57(19-21-58)17-4-2-3-8-39(60)54-37-7-5-6-35-41(37)46(65)59(45(35)64)38-15-16-40(61)55-44(38)63/h5-7,9,11,13-14,22-26,38H,2-4,8,15-21,27H2,1H3,(H,53,62)(H,54,60)(H,51,52,56)(H,55,61,63)","ZMLGGPCBMQWTLT-UHFFFAOYSA-N"
"3139","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","108.7","","Degradation of BCR-ABL T315I in Ba/F3 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","7.7/4.2/26.8","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","901.947","901.352314852","5.74","66","8","10","4","13","189.8","C48H46F3N9O6","InChI=1S/C48H46F3N9O6/c1-29-10-12-32(24-31(29)13-11-30-23-34-27-53-57-43(34)52-26-30)44(63)54-35-15-14-33(37(25-35)48(49,50)51)28-59-21-19-58(20-22-59)18-5-3-2-4-9-40(61)55-38-8-6-7-36-42(38)47(66)60(46(36)65)39-16-17-41(62)56-45(39)64/h6-8,10,12,14-15,23-27,39H,2-5,9,16-22,28H2,1H3,(H,54,63)(H,55,61)(H,52,53,57)(H,56,62,64)","HNQVKMYCDZGKOD-UHFFFAOYSA-N"
"3140","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","14/4.5/21.8","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","930.001","929.38361498","6.83","68","8","10","4","15","189.8","C50H50F3N9O6","InChI=1S/C50H50F3N9O6/c1-31-12-14-34(26-33(31)15-13-32-25-36-29-55-59-45(36)54-28-32)46(65)56-37-17-16-35(39(27-37)50(51,52)53)30-61-23-21-60(22-24-61)20-7-5-3-2-4-6-11-42(63)57-40-10-8-9-38-44(40)49(68)62(48(38)67)41-18-19-43(64)58-47(41)66/h8-10,12,14,16-17,25-29,41H,2-7,11,18-24,30H2,1H3,(H,56,65)(H,57,63)(H,54,55,59)(H,58,64,66)","NWVKCSXMTQVYKM-UHFFFAOYSA-N"
"3141","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","46.4/36.1/70.1","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","958.055","957.414915108","7.91","70","8","10","4","17","189.8","C52H54F3N9O6","InChI=1S/C52H54F3N9O6/c1-33-14-16-36(28-35(33)17-15-34-27-38-31-57-61-47(38)56-30-34)48(67)58-39-19-18-37(41(29-39)52(53,54)55)32-63-25-23-62(24-26-63)22-9-7-5-3-2-4-6-8-13-44(65)59-42-12-10-11-40-46(42)51(70)64(50(40)69)43-20-21-45(66)60-49(43)68/h10-12,14,16,18-19,27-31,43H,2-9,13,20-26,32H2,1H3,(H,58,67)(H,59,65)(H,56,57,61)(H,60,66,68)","RKUSZUHMCBXXMZ-UHFFFAOYSA-N"
"3142","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCCCCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","57.8/61/113.9","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","986.109","985.446215236","8.99","72","8","10","4","19","189.8","C54H58F3N9O6","InChI=1S/C54H58F3N9O6/c1-35-16-18-38(30-37(35)19-17-36-29-40-33-59-63-49(40)58-32-36)50(69)60-41-21-20-39(43(31-41)54(55,56)57)34-65-27-25-64(26-28-65)24-11-9-7-5-3-2-4-6-8-10-15-46(67)61-44-14-12-13-42-48(44)53(72)66(52(42)71)45-22-23-47(68)62-51(45)70/h12-14,16,18,20-21,29-33,45H,2-11,15,22-28,34H2,1H3,(H,60,69)(H,61,67)(H,58,59,63)(H,62,68,70)","ADQDCUJVPNXXBH-UHFFFAOYSA-N"
"3143","","BCR-ABL T315I","CRBN","","","CC1=CC=C(C(=O)NC2=CC=C(CN3CCN(CCCCCCCCCCCCCCC(=O)NC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)C(C(F)(F)F)=C2)C=C1C#CC1=CN=C2[NH]N=CC2=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","190.3/363.7/399.4","Inhibit proliferation of K562/(Ba/F3 WT)/(Ba/F3 BCR-ABL T315I) cells","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.009","1014.163","1013.47751536","10.07","74","8","10","4","21","189.8","C56H62F3N9O6","InChI=1S/C56H62F3N9O6/c1-37-18-20-40(32-39(37)21-19-38-31-42-35-61-65-51(42)60-34-38)52(71)62-43-23-22-41(45(33-43)56(57,58)59)36-67-29-27-66(28-30-67)26-13-11-9-7-5-3-2-4-6-8-10-12-17-48(69)63-46-16-14-15-44-50(46)55(74)68(54(44)73)47-24-25-49(70)64-53(47)72/h14-16,18,20,22-23,31-35,47H,2-13,17,24-30,36H2,1H3,(H,62,71)(H,63,69)(H,60,61,65)(H,64,70,72)","URMNTDTZQGNDRT-UHFFFAOYSA-N"
"3144","P04035","HMGCR","CRBN","","","C[C@H]1C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]2[C@@H](OC(=O)NCCCOCCOCCOCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","1250","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.001","822.953","822.405123296","3.43","59","6","13","4","20","208.13","C43H58N4O12","InChI=1S/C43H58N4O12/c1-26-22-28-9-8-27(2)31(11-10-30-24-29(48)25-37(50)58-30)38(28)35(23-26)59-43(54)45-15-5-17-56-19-21-57-20-18-55-16-4-14-44-33-7-3-6-32-39(33)42(53)47(41(32)52)34-12-13-36(49)46-40(34)51/h3,6-9,22,26-27,29-31,34-35,38,44,48H,4-5,10-21,23-25H2,1-2H3,(H,45,54)(H,46,49,51)/t26-,27-,29+,30+,31-,34?,35-,38-/m0/s1","OAVOTPDINFUFGU-UNNYYYJDSA-N"
"3145","P04035","HMGCR","CRBN","","","C[C@H]1C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]2[C@@H](OC(=O)NCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","1880","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.001","750.846","750.34760842","2.86","54","6","12","4","15","198.9","C39H50N4O11","InChI=1S/C39H50N4O11/c1-22-18-24-7-6-23(2)27(9-8-26-20-25(44)21-33(46)53-26)34(24)31(19-22)54-39(50)41-13-15-52-17-16-51-14-12-40-29-5-3-4-28-35(29)38(49)43(37(28)48)30-10-11-32(45)42-36(30)47/h3-7,18,22-23,25-27,30-31,34,40,44H,8-17,19-21H2,1-2H3,(H,41,50)(H,42,45,47)/t22-,23-,25+,26+,27-,30?,31-,34-/m0/s1","AUSYWJRVRIFOQR-HLZAIMANSA-N"
"3146","P04035","HMGCR","CRBN","","","C[C@H]1C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]2[C@@H](OC(=O)NCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","2490","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.001","676.767","676.310828988","3.51","49","6","10","4","10","180.44","C36H44N4O9","InChI=1S/C36H44N4O9/c1-19-15-21-8-7-20(2)24(10-9-23-17-22(41)18-30(43)48-23)31(21)28(16-19)49-36(47)38-14-4-13-37-26-6-3-5-25-32(26)35(46)40(34(25)45)27-11-12-29(42)39-33(27)44/h3,5-8,15,19-20,22-24,27-28,31,37,41H,4,9-14,16-18H2,1-2H3,(H,38,47)(H,39,42,44)/t19-,20-,22+,23+,24-,27?,28-,31-/m0/s1","FHGWSHJGRGJVPE-VNEMWKQGSA-N"
"3147","P04035","HMGCR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCNC(=O)O[C@H]3C[C@@H](C)C=C4C=C[C@H](C)[C@H](CC[C@@H]5C[C@@H](O)CC(=O)O5)[C@H]43)C(C)(C)C)C=C2)SC=N1","","","","","","1560","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1016/j.apsb.2020.11.001","918.211","917.497249852","6.89","65","6","11","5","18","196.49","C50H71N5O9S","InChI=1S/C50H71N5O9S/c1-30-22-35-16-13-31(2)39(20-19-38-24-36(56)26-43(59)63-38)44(35)41(23-30)64-49(62)51-21-11-9-7-8-10-12-42(58)54-46(50(4,5)6)48(61)55-28-37(57)25-40(55)47(60)52-27-33-14-17-34(18-15-33)45-32(3)53-29-65-45/h13-18,22,29-31,36-41,44,46,56-57H,7-12,19-21,23-28H2,1-6H3,(H,51,62)(H,52,60)(H,54,58)/t30-,31-,36+,37+,38+,39-,40-,41-,44-,46+/m0/s1","AILLILTYHCAGPA-NUMZSJKDSA-N"
"3148","P04035","HMGCR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)O[C@H]3C[C@@H](C)C=C4C=C[C@H](C)[C@H](CC[C@@H]5C[C@@H](O)CC(=O)O5)[C@H]43)C(C)(C)C)C=C2)SC=N1","","","","","","1320","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","27.98","Caco-2 A2B assay","","","10.1016/j.apsb.2020.11.001","960.292","959.544200044","8.52","68","6","11","5","21","196.49","C53H77N5O9S","InChI=1S/C53H77N5O9S/c1-33-25-38-19-16-34(2)42(23-22-41-27-39(59)29-46(62)66-41)47(38)44(26-33)67-52(65)54-24-14-12-10-8-7-9-11-13-15-45(61)57-49(53(4,5)6)51(64)58-31-40(60)28-43(58)50(63)55-30-36-17-20-37(21-18-36)48-35(3)56-32-68-48/h16-21,25,32-34,39-44,47,49,59-60H,7-15,22-24,26-31H2,1-6H3,(H,54,65)(H,55,63)(H,57,61)/t33-,34-,39+,40+,41+,42-,43-,44-,47-,49+/m0/s1","KDZGHUAZCDSHGD-XQKMAAOKSA-N"
"3149","P04035","HMGCR","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)O[C@H]3C[C@@H](C)C=C4C=C[C@H](C)[C@H](CCC(O)C[C@@H](O)CC(=O)O)[C@H]43)C(C)(C)C)C=C2)SC=N1","120","76","Degradation of HMGCR in HepG2 cells after 16 h treatment","","","250","Inhibition of HMGCR","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","18.22","Caco-2 A2B assay","","","10.1016/j.apsb.2020.11.001","978.307","977.554764728","7.73","69","5","11","7","25","227.72","C53H79N5O10S","InChI=1S/C53H79N5O10S/c1-33-25-38-19-16-34(2)42(23-22-39(59)27-40(60)29-46(63)64)47(38)44(26-33)68-52(67)54-24-14-12-10-8-7-9-11-13-15-45(62)57-49(53(4,5)6)51(66)58-31-41(61)28-43(58)50(65)55-30-36-17-20-37(21-18-36)48-35(3)56-32-69-48/h16-21,25,32-34,39-44,47,49,59-61H,7-15,22-24,26-31H2,1-6H3,(H,54,67)(H,55,65)(H,57,62)(H,63,64)/t33-,34-,39?,40+,41+,42-,43-,44-,47-,49+/m0/s1","YASBQIQZXTUKLR-SHAIEYSUSA-N"
"3150","O60885","BRD4","CRBN","","CFT-1297","CC1=NN=C2N1C1=CC=C(C3=CN(CCCCCCCN4CCC(C5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)N=C3)C=C1C(C1=CC=C(Cl)C=C1)=NC21CC1","5","97","Degradation of BRD4 in HEK293T cells after 3 h treatment","","","","","","","58","Kd of BRD4 BD1 was assessed by FP","","","","","","","","","","","","","","","2100","FP","","","","","","","","","","","","","","","4","Kd was tested by AlphaLISA assay","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acschembio.1c00376","824.43","823.37251414","5.95","60","10","10","1","12","130.61","C47H50ClN9O3","InChI=1S/C47H50ClN9O3/c1-30-52-53-46-47(20-21-47)51-43(32-10-13-35(48)14-11-32)38-26-33(12-15-40(38)57(30)46)34-27-49-55(28-34)23-6-4-2-3-5-22-54-24-18-31(19-25-54)36-8-7-9-37-39(36)29-56(45(37)60)41-16-17-42(58)50-44(41)59/h7-15,26-28,31,41H,2-6,16-25,29H2,1H3,(H,50,58,59)","SDKKICDYRHTFNX-UHFFFAOYSA-N"
"3151","P11802","CDK4","CRBN","","SAB355","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00368","936.04","935.428987024","0.35","68","8","17","4","20","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-25-50-47(54-43(34)58(31-6-3-4-7-31)46(65)42(29)30(2)59)52-38-12-10-32(24-49-38)56-17-15-55(16-18-56)27-40(61)48-14-19-66-20-21-67-22-23-68-28-41(62)51-36-9-5-8-33-35(36)26-57(45(33)64)37-11-13-39(60)53-44(37)63/h5,8-10,12,24-25,31,37H,3-4,6-7,11,13-23,26-28H2,1-2H3,(H,48,61)(H,51,62)(H,53,60,63)(H,49,50,52,54)","ROGURJAGCVFXED-UHFFFAOYSA-N"
"3151","Q00534","CDK6","CRBN","","SAB355","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCC(=O)NC5=CC=CC6=C5CN(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00368","936.04","935.428987024","0.35","68","8","17","4","20","248.62","C47H57N11O10","InChI=1S/C47H57N11O10/c1-29-34-25-50-47(54-43(34)58(31-6-3-4-7-31)46(65)42(29)30(2)59)52-38-12-10-32(24-49-38)56-17-15-55(16-18-56)27-40(61)48-14-19-66-20-21-67-22-23-68-28-41(62)51-36-9-5-8-33-35(36)26-57(45(33)64)37-11-13-39(60)53-44(37)63/h5,8-10,12,24-25,31,37H,3-4,6-7,11,13-23,26-28H2,1-2H3,(H,48,61)(H,51,62)(H,53,60,63)(H,49,50,52,54)","ROGURJAGCVFXED-UHFFFAOYSA-N"
"3152","P11802","CDK4","CRBN","","SAB401","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC(=O)NCCOCCOCCOCC(=O)NCC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/acsmedchemlett.1c00368","964.05","963.423901644","0.23","70","8","18","4","21","265.69","C48H57N11O11","InChI=1S/C48H57N11O11/c1-29-35-26-52-48(55-43(35)58(32-7-3-4-8-32)46(66)41(29)30(2)60)53-37-12-10-33(25-50-37)57-17-15-56(16-18-57)27-39(62)49-14-19-68-20-21-69-22-23-70-28-40(63)51-24-31-6-5-9-34-42(31)47(67)59(45(34)65)36-11-13-38(61)54-44(36)64/h5-6,9-10,12,25-26,32,36H,3-4,7-8,11,13-24,27-28H2,1-2H3,(H,49,62)(H,51,63)(H,54,61,64)(H,50,52,53,55)","ZWPCIMZVFJDXRU-UHFFFAOYSA-N"
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"3168","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2CCN(C(=O)CCCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/ardp.202100467","898.021","897.34953798","7.87","64","7","9","2","15","163.23","C47H50F3N7O6S","InChI=1S/C47H50F3N7O6S/c1-46(2)44(63)55(33-19-16-31(28-51)35(27-33)47(48,49)50)45(64)57(46)32-17-14-29(15-18-32)30-22-25-54(26-23-30)39(59)13-8-6-4-3-5-7-9-24-52-36-12-10-11-34-40(36)43(62)56(42(34)61)37-20-21-38(58)53-41(37)60/h10-12,14-19,27,30,37,52H,3-9,13,20-26H2,1-2H3,(H,53,58,60)","TWPKOFOJYNQJLZ-UHFFFAOYSA-N"
"3169","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2=CC=C(OCC#CC3=CC=C(C(=O)N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C=C3)C=C2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/ardp.202100467","963.995","963.26620228","6.97","70","9","10","1","8","163.67","C52H40F3N7O7S","InChI=1S/C52H40F3N7O7S/c1-51(2)49(68)60(38-16-11-35(30-56)42(29-38)52(53,54)55)50(70)62(51)36-14-9-32(10-15-36)33-12-18-39(19-13-33)69-27-3-4-31-5-7-34(8-6-31)46(65)59-25-23-58(24-26-59)37-17-20-40-41(28-37)48(67)61(47(40)66)43-21-22-44(63)57-45(43)64/h5-20,28-29,43H,21-27H2,1-2H3,(H,57,63,64)","FQVZECRSOLVDIC-UHFFFAOYSA-N"
"3170","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2=CC=C(OCC#CC3=CC=C(C(=O)N4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)CC6=C5)CC4)C=C3)C=C2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/ardp.202100467","950.012","949.286937724","7.03","69","9","9","1","8","146.6","C52H42F3N7O6S","InChI=1S/C52H42F3N7O6S/c1-51(2)49(67)61(40-16-11-36(30-56)43(29-40)52(53,54)55)50(69)62(51)38-14-9-33(10-15-38)34-12-18-41(19-13-34)68-27-3-4-32-5-7-35(8-6-32)47(65)59-25-23-58(24-26-59)39-17-20-42-37(28-39)31-60(48(42)66)44-21-22-45(63)57-46(44)64/h5-20,28-29,44H,21-27,31H2,1-2H3,(H,57,63,64)","JABPCGCHPUNQKQ-UHFFFAOYSA-N"
"3171","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2=CC=C(O[C@@H]3CCN(C(=O)C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)C=C1","75/77",">75/>85","Degradation of AR in A549/LNCaP cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/ardp.202100467","917.967","917.281852344","6.0","66","9","10","1","8","163.67","C48H42F3N7O7S","InChI=1S/C48H42F3N7O7S/c1-47(2)45(64)56(33-10-5-30(25-52)38(24-33)48(49,50)51)46(66)58(47)31-8-3-27(4-9-31)28-6-12-34(13-7-28)65-35-19-22-55(26-35)42(61)29-17-20-54(21-18-29)32-11-14-36-37(23-32)44(63)57(43(36)62)39-15-16-40(59)53-41(39)60/h3-14,23-24,29,35,39H,15-22,26H2,1-2H3,(H,53,59,60)/t35-,39?/m1/s1","PMTYRQFZOZEPEI-QQKHLPPFSA-N"
"3172","P10275","AR","CRBN","","","CC1(C)C(=O)N(C2=CC=C(C#N)C(C(F)(F)F)=C2)C(=S)N1C1=CC=C(C2=CC=C(O[C@H]3CCN(C(=O)C4CCN(C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)CC4)C3)C=C2)C=C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1002/ardp.202100467","917.967","917.281852344","6.0","66","9","10","1","8","163.67","C48H42F3N7O7S","InChI=1S/C48H42F3N7O7S/c1-47(2)45(64)56(33-10-5-30(25-52)38(24-33)48(49,50)51)46(66)58(47)31-8-3-27(4-9-31)28-6-12-34(13-7-28)65-35-19-22-55(26-35)42(61)29-17-20-54(21-18-29)32-11-14-36-37(23-32)44(63)57(43(36)62)39-15-16-40(59)53-41(39)60/h3-14,23-24,29,35,39H,15-22,26H2,1-2H3,(H,53,59,60)/t35-,39?/m0/s1","PMTYRQFZOZEPEI-DIHCPYQKSA-N"
"3173","O75533","SF3B1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCNC(=O)C4=CSC(NC5=CC=C(Cl)C=C5)=N4)=C3C2=O)C(=O)N1","244","","Degradation of SF3B1 in K562 cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","227.9","Inhibit growth of K562 cells","","","","","","","","","","","","","","","10.1016/j.chembiol.2021.04.018","609.108","608.160866708","4.93","42","5","9","4","12","149.6","C29H29ClN6O5S","InChI=1S/C29H29ClN6O5S/c30-17-8-10-18(11-9-17)33-29-34-21(16-42-29)25(38)32-15-4-2-1-3-14-31-20-7-5-6-19-24(20)28(41)36(27(19)40)22-12-13-23(37)35-26(22)39/h5-11,16,22,31H,1-4,12-15H2,(H,32,38)(H,33,34)(H,35,37,39)","UWYLVQJEOCYCEW-UHFFFAOYSA-N"
"3173","O75533","SF3B1 K400E","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCCCNC(=O)C4=CSC(NC5=CC=C(Cl)C=C5)=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","90.2","Inhibit K562 cells to express SF3B1 K700E","","","","","","","","","","","","","","","10.1016/j.chembiol.2021.04.018","609.108","608.160866708","4.93","42","5","9","4","12","149.6","C29H29ClN6O5S","InChI=1S/C29H29ClN6O5S/c30-17-8-10-18(11-9-17)33-29-34-21(16-42-29)25(38)32-15-4-2-1-3-14-31-20-7-5-6-19-24(20)28(41)36(27(19)40)22-12-13-23(37)35-26(22)39/h5-11,16,22,31H,1-4,12-15H2,(H,32,38)(H,33,34)(H,35,37,39)","UWYLVQJEOCYCEW-UHFFFAOYSA-N"
"3174","Q06187","BTK","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","18","","Degradation of BTK in HeLa cells after 96 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","12","Inhibit growth of HBL-1 cells","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3174","Q06187","BTK C481S","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","29","","Degradation of BTK C481S in HBL-1 cells after 36 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","64/<10","Inhibit growth of HBL-1 (BTK C481S)/Mino (BTK C481S) cells","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3174","Q06187","BTK C481T","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","38","","Degradation of BTK C481T in HeLa cells after 96 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3174","Q06187","BTK C481G","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","26","","Degradation of BTK C481G in HeLa cells after 96 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3174","Q06187","BTK C481W","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","41","","Degradation of BTK C481W in HeLa cells after 96 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3174","Q06187","BTK C481A","CRBN","","L18I","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)C2=CN(CCOCCOCCOCCCC3=CC=CC4=C3CN(C3CCC(=O)NC3=O)C4=O)N=N2)C1","15","","Degradation of BTK C481A in HeLa cells after 96 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41375-019-0440-x","897.994","897.392207592","2.8","66","9","16","2","19","224.04","C47H51N11O8","InChI=1S/C47H51N11O8/c48-43-41-42(32-13-15-35(16-14-32)66-34-10-2-1-3-11-34)53-58(44(41)50-30-49-43)33-9-5-19-55(27-33)47(62)38-29-56(54-52-38)20-22-64-24-26-65-25-23-63-21-6-8-31-7-4-12-36-37(31)28-57(46(36)61)39-17-18-40(59)51-45(39)60/h1-4,7,10-16,29-30,33,39H,5-6,8-9,17-28H2,(H2,48,49,50)(H,51,59,60)/t33-,39?/m1/s1","PQIHIELQKZACPK-LXJLEQQOSA-N"
"3175","Q06187","BTK","CRBN","","GBD-2","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","755.836","755.317980032","4.42","56","8","12","3","12","194.74","C41H41N9O6","InChI=1S/C41H41N9O6/c42-37-35-36(25-15-17-28(18-16-25)56-27-10-3-1-4-11-27)47-50(38(35)45-24-44-37)26-9-8-22-48(23-26)33(52)14-5-2-6-21-43-30-13-7-12-29-34(30)41(55)49(40(29)54)31-19-20-32(51)46-39(31)53/h1,3-4,7,10-13,15-18,24,26,31,43H,2,5-6,8-9,14,19-23H2,(H2,42,44,45)(H,46,51,53)/t26-,31?/m1/s1","YFYDKJKVOSGWOG-SYQKMTEESA-N"
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"3180","Q06187","BTK","CRBN","","GBD-8","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","797.917","797.364930224","6.05","59","8","12","3","15","194.74","C44H47N9O6","InChI=1S/C44H47N9O6/c45-40-38-39(28-18-20-31(21-19-28)59-30-13-6-5-7-14-30)50-53(41(38)48-27-47-40)29-12-11-25-51(26-29)36(55)17-8-3-1-2-4-9-24-46-33-16-10-15-32-37(33)44(58)52(43(32)57)34-22-23-35(54)49-42(34)56/h5-7,10,13-16,18-21,27,29,34,46H,1-4,8-9,11-12,17,22-26H2,(H2,45,47,48)(H,49,54,56)/t29-,34?/m1/s1","NEMGYBVVFUXINK-QMUARQKKSA-N"
"3181","Q06187","BTK","CRBN","","GBD-9","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1","37","","Degradation of BTK in DOHH2 cells after 24 h treatment","","","","","","","990/44","Kd was tested by ITC/KINOMEscan","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","133","Inhibit proliferation of DOHH2 cells","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","797.917","797.364930224","5.5","59","8","12","3","15","194.74","C44H47N9O6","InChI=1S/C44H47N9O6/c45-40-38-39(28-15-18-32(19-16-28)59-31-12-6-5-7-13-31)50-53(41(38)48-27-47-40)30-11-10-24-51(26-30)37(55)14-8-3-1-2-4-9-23-46-29-17-20-33-34(25-29)44(58)52(43(33)57)35-21-22-36(54)49-42(35)56/h5-7,12-13,15-20,25,27,30,35,46H,1-4,8-11,14,21-24,26H2,(H2,45,47,48)(H,49,54,56)/t30-,35?/m1/s1","DCJYQURCBHSFEP-OSRRZMJMSA-N"
"3182","Q06187","BTK","CRBN","","GBD-10","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","811.944","811.380580288","6.59","60","8","12","3","16","194.74","C45H49N9O6","InChI=1S/C45H49N9O6/c46-41-39-40(29-19-21-32(22-20-29)60-31-14-7-6-8-15-31)51-54(42(39)49-28-48-41)30-13-12-26-52(27-30)37(56)18-9-4-2-1-3-5-10-25-47-34-17-11-16-33-38(34)45(59)53(44(33)58)35-23-24-36(55)50-43(35)57/h6-8,11,14-17,19-22,28,30,35,47H,1-5,9-10,12-13,18,23-27H2,(H2,46,48,49)(H,50,55,57)/t30-,35?/m1/s1","KTNACPSCIYENFN-OSRRZMJMSA-N"
"3183","Q06187","BTK","CRBN","","GBD-11","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","811.944","811.380580288","6.04","60","8","12","3","16","194.74","C45H49N9O6","InChI=1S/C45H49N9O6/c46-41-39-40(29-16-19-33(20-17-29)60-32-13-7-6-8-14-32)51-54(42(39)49-28-48-41)31-12-11-25-52(27-31)38(56)15-9-4-2-1-3-5-10-24-47-30-18-21-34-35(26-30)45(59)53(44(34)58)36-22-23-37(55)50-43(36)57/h6-8,13-14,16-21,26,28,31,36,47H,1-5,9-12,15,22-25,27H2,(H2,46,48,49)(H,50,55,57)/t31-,36?/m1/s1","TXQUGROTXYOXMO-RACIXVTASA-N"
"3184","Q06187","BTK","CRBN","","GBD-12","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","825.971","825.396230352","7.13","61","8","12","3","17","194.74","C46H51N9O6","InChI=1S/C46H51N9O6/c47-42-40-41(30-20-22-33(23-21-30)61-32-15-8-7-9-16-32)52-55(43(40)50-29-49-42)31-14-13-27-53(28-31)38(57)19-10-5-3-1-2-4-6-11-26-48-35-18-12-17-34-39(35)46(60)54(45(34)59)36-24-25-37(56)51-44(36)58/h7-9,12,15-18,20-23,29,31,36,48H,1-6,10-11,13-14,19,24-28H2,(H2,47,49,50)(H,51,56,58)/t31-,36?/m1/s1","ZOWOGIBTZKPHRP-RACIXVTASA-N"
"3185","Q06187","BTK","CRBN","","GBD-13","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","825.971","825.396230352","6.58","61","8","12","3","17","194.74","C46H51N9O6","InChI=1S/C46H51N9O6/c47-42-40-41(30-17-20-34(21-18-30)61-33-14-8-7-9-15-33)52-55(43(40)50-29-49-42)32-13-12-26-53(28-32)39(57)16-10-5-3-1-2-4-6-11-25-48-31-19-22-35-36(27-31)46(60)54(45(35)59)37-23-24-38(56)51-44(37)58/h7-9,14-15,17-22,27,29,32,37,48H,1-6,10-13,16,23-26,28H2,(H2,47,49,50)(H,51,56,58)/t32-,37?/m1/s1","IRHJWGMAWWUWEA-ZIQZBVCVSA-N"
"3186","Q06187","BTK","CRBN","","GBD-14","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","839.998","839.411880416","7.67","62","8","12","3","18","194.74","C47H53N9O6","InChI=1S/C47H53N9O6/c48-43-41-42(31-21-23-34(24-22-31)62-33-16-9-8-10-17-33)53-56(44(41)51-30-50-43)32-15-14-28-54(29-32)39(58)20-11-6-4-2-1-3-5-7-12-27-49-36-19-13-18-35-40(36)47(61)55(46(35)60)37-25-26-38(57)52-45(37)59/h8-10,13,16-19,21-24,30,32,37,49H,1-7,11-12,14-15,20,25-29H2,(H2,48,50,51)(H,52,57,59)/t32-,37?/m1/s1","RWIAYIGXNMKZHF-ZIQZBVCVSA-N"
"3187","Q06187","BTK","CRBN","","GBD-15","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCCCCCCCCCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","839.998","839.411880416","7.12","62","8","12","3","18","194.74","C47H53N9O6","InChI=1S/C47H53N9O6/c48-43-41-42(31-18-21-35(22-19-31)62-34-15-9-8-10-16-34)53-56(44(41)51-30-50-43)33-14-13-27-54(29-33)40(58)17-11-6-4-2-1-3-5-7-12-26-49-32-20-23-36-37(28-32)47(61)55(46(36)60)38-24-25-39(57)52-45(38)59/h8-10,15-16,18-23,28,30,33,38,49H,1-7,11-14,17,24-27,29H2,(H2,48,50,51)(H,52,57,59)/t33-,38?/m1/s1","GCTKAZBZZAIKCL-OVFDOZPJSA-N"
"3188","Q06187","BTK","CRBN","","GBD-16","NC1=NC=NC2=C1C(C1=CC=C(OC3=CC=CC=C3)C=C1)=NN2[C@@H]1CCCN(C(=O)CCOCCOCCNC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2)C1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41422-021-00533-6","801.861","801.323459336","2.5","59","8","14","3","15","213.2","C42H43N9O8","InChI=1S/C42H43N9O8/c43-38-36-37(26-8-11-30(12-9-26)59-29-6-2-1-3-7-29)48-51(39(36)46-25-45-38)28-5-4-18-49(24-28)35(53)16-19-57-21-22-58-20-17-44-27-10-13-31-32(23-27)42(56)50(41(31)55)33-14-15-34(52)47-40(33)54/h1-3,6-13,23,25,28,33,44H,4-5,14-22,24H2,(H2,43,45,46)(H,47,52,54)/t28-,33?/m1/s1","UCTGQBPFCSBHTA-TUDONDPESA-N"
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"3212","P55055","LXRB","CRBN","","GW3965-PEG5-POM","O=C(CC1=CC=CC(OCCCN(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C2=CC=CC=C2)C2=CC=CC=C2)=C1)NCCOCCOCCOCCOCCOCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3389/fchem.2021.674967","1114.612","1113.4113848","6.84","79","7","13","3","32","200.37","C58H63ClF3N5O12","InChI=1S/C58H63ClF3N5O12/c59-54-43(16-8-19-47(54)58(60,61)62)37-66(38-46(41-12-3-1-4-13-41)42-14-5-2-6-15-42)24-10-25-79-44-17-7-11-40(35-44)36-51(69)63-23-26-74-27-28-75-29-30-76-31-32-77-33-34-78-39-52(70)64-48-20-9-18-45-53(48)57(73)67(56(45)72)49-21-22-50(68)65-55(49)71/h1-9,11-20,35,46,49H,10,21-34,36-39H2,(H,63,69)(H,64,70)(H,65,68,71)","GAMAJZWSYMRZFB-UHFFFAOYSA-N"
"3213","P10415","BCL2","VHL","","PPC5","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","47","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1599.442","1597.60489933","10.87","109","11","19","5","28","263.54","C79H99ClF3N11O11S4","InChI=1S/C79H99ClF3N11O11S4/c1-53(55-15-17-57(18-16-55)72-54(2)84-52-107-72)85-75(99)68-45-63(95)49-94(68)76(100)73(77(3,4)5)87-70(96)13-10-14-71(97)93-39-35-91(36-40-93)51-78(6)31-29-66(56-19-23-60(80)24-20-56)59(47-78)48-90-33-37-92(38-34-90)62-25-21-58(22-26-62)74(98)88-109(103,104)65-27-28-67(69(46-65)108(101,102)79(81,82)83)86-61(30-32-89-41-43-105-44-42-89)50-106-64-11-8-7-9-12-64/h7-9,11-12,15-28,46,52-53,61,63,68,73,86,95H,10,13-14,29-45,47-51H2,1-6H3,(H,85,99)(H,87,96)(H,88,98)/t53-,61+,63+,68-,73+,78?/m0/s1","BRIZMACXBJUXJT-UWPVXNPMSA-N"
"3213","Q07817","BCL-xL","VHL","","PPC5","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","316.2","56","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1599.442","1597.60489933","10.87","109","11","19","5","28","263.54","C79H99ClF3N11O11S4","InChI=1S/C79H99ClF3N11O11S4/c1-53(55-15-17-57(18-16-55)72-54(2)84-52-107-72)85-75(99)68-45-63(95)49-94(68)76(100)73(77(3,4)5)87-70(96)13-10-14-71(97)93-39-35-91(36-40-93)51-78(6)31-29-66(56-19-23-60(80)24-20-56)59(47-78)48-90-33-37-92(38-34-90)62-25-21-58(22-26-62)74(98)88-109(103,104)65-27-28-67(69(46-65)108(101,102)79(81,82)83)86-61(30-32-89-41-43-105-44-42-89)50-106-64-11-8-7-9-12-64/h7-9,11-12,15-28,46,52-53,61,63,68,73,86,95H,10,13-14,29-45,47-51H2,1-6H3,(H,85,99)(H,87,96)(H,88,98)/t53-,61+,63+,68-,73+,78?/m0/s1","BRIZMACXBJUXJT-UWPVXNPMSA-N"
"3214","P10415","BCL2","VHL","","PPC6","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","47","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1613.469","1611.62054939","11.23","110","11","19","5","29","263.54","C80H101ClF3N11O11S4","InChI=1S/C80H101ClF3N11O11S4/c1-54(56-16-18-58(19-17-56)73-55(2)85-53-108-73)86-76(100)69-46-64(96)50-95(69)77(101)74(78(3,4)5)88-71(97)14-10-11-15-72(98)94-40-36-92(37-41-94)52-79(6)32-30-67(57-20-24-61(81)25-21-57)60(48-79)49-91-34-38-93(39-35-91)63-26-22-59(23-27-63)75(99)89-110(104,105)66-28-29-68(70(47-66)109(102,103)80(82,83)84)87-62(31-33-90-42-44-106-45-43-90)51-107-65-12-8-7-9-13-65/h7-9,12-13,16-29,47,53-54,62,64,69,74,87,96H,10-11,14-15,30-46,48-52H2,1-6H3,(H,86,100)(H,88,97)(H,89,99)/t54-,62+,64+,69-,74+,79?/m0/s1","KVQKGBLSBLWZKE-AAWIYDMSSA-N"
"3214","Q07817","BCL-xL","VHL","","PPC6","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","39.9","91","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1613.469","1611.62054939","11.23","110","11","19","5","29","263.54","C80H101ClF3N11O11S4","InChI=1S/C80H101ClF3N11O11S4/c1-54(56-16-18-58(19-17-56)73-55(2)85-53-108-73)86-76(100)69-46-64(96)50-95(69)77(101)74(78(3,4)5)88-71(97)14-10-11-15-72(98)94-40-36-92(37-41-94)52-79(6)32-30-67(57-20-24-61(81)25-21-57)60(48-79)49-91-34-38-93(39-35-91)63-26-22-59(23-27-63)75(99)89-110(104,105)66-28-29-68(70(47-66)109(102,103)80(82,83)84)87-62(31-33-90-42-44-106-45-43-90)51-107-65-12-8-7-9-13-65/h7-9,12-13,16-29,47,53-54,62,64,69,74,87,96H,10-11,14-15,30-46,48-52H2,1-6H3,(H,86,100)(H,88,97)(H,89,99)/t54-,62+,64+,69-,74+,79?/m0/s1","KVQKGBLSBLWZKE-AAWIYDMSSA-N"
"3215","P10415","BCL2","VHL","","PPC7","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","179.9","79","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1627.496","1625.63619946","11.77","111","11","19","5","30","263.54","C81H103ClF3N11O11S4","InChI=1S/C81H103ClF3N11O11S4/c1-55(57-17-19-59(20-18-57)74-56(2)86-54-109-74)87-77(101)70-47-65(97)51-96(70)78(102)75(79(3,4)5)89-72(98)15-11-8-12-16-73(99)95-41-37-93(38-42-95)53-80(6)33-31-68(58-21-25-62(82)26-22-58)61(49-80)50-92-35-39-94(40-36-92)64-27-23-60(24-28-64)76(100)90-111(105,106)67-29-30-69(71(48-67)110(103,104)81(83,84)85)88-63(32-34-91-43-45-107-46-44-91)52-108-66-13-9-7-10-14-66/h7,9-10,13-14,17-30,48,54-55,63,65,70,75,88,97H,8,11-12,15-16,31-47,49-53H2,1-6H3,(H,87,101)(H,89,98)(H,90,100)/t55-,63+,65+,70-,75+,80?/m0/s1","XXWWYTHQXVIKLW-WGWDJEQESA-N"
"3215","Q07817","BCL-xL","VHL","","PPC7","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","12.8","85","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1627.496","1625.63619946","11.77","111","11","19","5","30","263.54","C81H103ClF3N11O11S4","InChI=1S/C81H103ClF3N11O11S4/c1-55(57-17-19-59(20-18-57)74-56(2)86-54-109-74)87-77(101)70-47-65(97)51-96(70)78(102)75(79(3,4)5)89-72(98)15-11-8-12-16-73(99)95-41-37-93(38-42-95)53-80(6)33-31-68(58-21-25-62(82)26-22-58)61(49-80)50-92-35-39-94(40-36-92)64-27-23-60(24-28-64)76(100)90-111(105,106)67-29-30-69(71(48-67)110(103,104)81(83,84)85)88-63(32-34-91-43-45-107-46-44-91)52-108-66-13-9-7-10-14-66/h7,9-10,13-14,17-30,48,54-55,63,65,70,75,88,97H,8,11-12,15-16,31-47,49-53H2,1-6H3,(H,87,101)(H,89,98)(H,90,100)/t55-,63+,65+,70-,75+,80?/m0/s1","XXWWYTHQXVIKLW-WGWDJEQESA-N"
"3216","P10415","BCL2","VHL","","PPC8","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","54","94","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81?/m0/s1","KQEMZZJSHJCPSI-KGENNJKMSA-N"
"3216","Q07817","BCL-xL","VHL","","PPC8","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","12.9","94","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81?/m0/s1","KQEMZZJSHJCPSI-KGENNJKMSA-N"
"3217","P10415","BCL2","VHL","","PPC9","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","316.2","79","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1655.55","1653.66749958","12.86","113","11","19","5","32","263.54","C83H107ClF3N11O11S4","InChI=1S/C83H107ClF3N11O11S4/c1-57(59-19-21-61(22-20-59)76-58(2)88-56-111-76)89-79(103)72-49-67(99)53-98(72)80(104)77(81(3,4)5)91-74(100)17-13-8-7-9-14-18-75(101)97-43-39-95(40-44-97)55-82(6)35-33-70(60-23-27-64(84)28-24-60)63(51-82)52-94-37-41-96(42-38-94)66-29-25-62(26-30-66)78(102)92-113(107,108)69-31-32-71(73(50-69)112(105,106)83(85,86)87)90-65(34-36-93-45-47-109-48-46-93)54-110-68-15-11-10-12-16-68/h10-12,15-16,19-32,50,56-57,65,67,72,77,90,99H,7-9,13-14,17-18,33-49,51-55H2,1-6H3,(H,89,103)(H,91,100)(H,92,102)/t57-,65+,67+,72-,77+,82?/m0/s1","YCSHJMBQFQHZEP-BMNBLYSOSA-N"
"3217","Q07817","BCL-xL","VHL","","PPC9","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","12.8","96","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1655.55","1653.66749958","12.86","113","11","19","5","32","263.54","C83H107ClF3N11O11S4","InChI=1S/C83H107ClF3N11O11S4/c1-57(59-19-21-61(22-20-59)76-58(2)88-56-111-76)89-79(103)72-49-67(99)53-98(72)80(104)77(81(3,4)5)91-74(100)17-13-8-7-9-14-18-75(101)97-43-39-95(40-44-97)55-82(6)35-33-70(60-23-27-64(84)28-24-60)63(51-82)52-94-37-41-96(42-38-94)66-29-25-62(26-30-66)78(102)92-113(107,108)69-31-32-71(73(50-69)112(105,106)83(85,86)87)90-65(34-36-93-45-47-109-48-46-93)54-110-68-15-11-10-12-16-68/h10-12,15-16,19-32,50,56-57,65,67,72,77,90,99H,7-9,13-14,17-18,33-49,51-55H2,1-6H3,(H,89,103)(H,91,100)(H,92,102)/t57-,65+,67+,72-,77+,82?/m0/s1","YCSHJMBQFQHZEP-BMNBLYSOSA-N"
"3218","P10415","BCL2","VHL","","PPC10","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","354.8","69","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1669.577","1667.68314965","13.4","114","11","19","5","33","263.54","C84H109ClF3N11O11S4","InChI=1S/C84H109ClF3N11O11S4/c1-58(60-20-22-62(23-21-60)77-59(2)89-57-112-77)90-80(104)73-50-68(100)54-99(73)81(105)78(82(3,4)5)92-75(101)18-14-9-7-8-10-15-19-76(102)98-44-40-96(41-45-98)56-83(6)36-34-71(61-24-28-65(85)29-25-61)64(52-83)53-95-38-42-97(43-39-95)67-30-26-63(27-31-67)79(103)93-114(108,109)70-32-33-72(74(51-70)113(106,107)84(86,87)88)91-66(35-37-94-46-48-110-49-47-94)55-111-69-16-12-11-13-17-69/h11-13,16-17,20-33,51,57-58,66,68,73,78,91,100H,7-10,14-15,18-19,34-50,52-56H2,1-6H3,(H,90,104)(H,92,101)(H,93,103)/t58-,66+,68+,73-,78+,83?/m0/s1","CGIQKSDNJNCLMP-PVVVILJQSA-N"
"3218","Q07817","BCL-xL","VHL","","PPC10","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","12.1","81","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1669.577","1667.68314965","13.4","114","11","19","5","33","263.54","C84H109ClF3N11O11S4","InChI=1S/C84H109ClF3N11O11S4/c1-58(60-20-22-62(23-21-60)77-59(2)89-57-112-77)90-80(104)73-50-68(100)54-99(73)81(105)78(82(3,4)5)92-75(101)18-14-9-7-8-10-15-19-76(102)98-44-40-96(41-45-98)56-83(6)36-34-71(61-24-28-65(85)29-25-61)64(52-83)53-95-38-42-97(43-39-95)67-30-26-63(27-31-67)79(103)93-114(108,109)70-32-33-72(74(51-70)113(106,107)84(86,87)88)91-66(35-37-94-46-48-110-49-47-94)55-111-69-16-12-11-13-17-69/h11-13,16-17,20-33,51,57-58,66,68,73,78,91,100H,7-10,14-15,18-19,34-50,52-56H2,1-6H3,(H,90,104)(H,92,101)(H,93,103)/t58-,66+,68+,73-,78+,83?/m0/s1","CGIQKSDNJNCLMP-PVVVILJQSA-N"
"3219","P10415","BCL2","VHL","","PPC11","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","38","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1683.604","1681.69879971","13.94","115","11","19","5","34","263.54","C85H111ClF3N11O11S4","InChI=1S/C85H111ClF3N11O11S4/c1-59(61-21-23-63(24-22-61)78-60(2)90-58-113-78)91-81(105)74-51-69(101)55-100(74)82(106)79(83(3,4)5)93-76(102)19-15-10-8-7-9-11-16-20-77(103)99-45-41-97(42-46-99)57-84(6)37-35-72(62-25-29-66(86)30-26-62)65(53-84)54-96-39-43-98(44-40-96)68-31-27-64(28-32-68)80(104)94-115(109,110)71-33-34-73(75(52-71)114(107,108)85(87,88)89)92-67(36-38-95-47-49-111-50-48-95)56-112-70-17-13-12-14-18-70/h12-14,17-18,21-34,52,58-59,67,69,74,79,92,101H,7-11,15-16,19-20,35-51,53-57H2,1-6H3,(H,91,105)(H,93,102)(H,94,104)/t59-,67+,69+,74-,79+,84?/m0/s1","UQQFHLGCSOEWFT-SPQPUINASA-N"
"3219","Q07817","BCL-xL","VHL","","PPC11","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)N3CCN(CC4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","38","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1683.604","1681.69879971","13.94","115","11","19","5","34","263.54","C85H111ClF3N11O11S4","InChI=1S/C85H111ClF3N11O11S4/c1-59(61-21-23-63(24-22-61)78-60(2)90-58-113-78)91-81(105)74-51-69(101)55-100(74)82(106)79(83(3,4)5)93-76(102)19-15-10-8-7-9-11-16-20-77(103)99-45-41-97(42-46-99)57-84(6)37-35-72(62-25-29-66(86)30-26-62)65(53-84)54-96-39-43-98(44-40-96)68-31-27-64(28-32-68)80(104)94-115(109,110)71-33-34-73(75(52-71)114(107,108)85(87,88)89)92-67(36-38-95-47-49-111-50-48-95)56-112-70-17-13-12-14-18-70/h12-14,17-18,21-34,52,58-59,67,69,74,79,92,101H,7-11,15-16,19-20,35-51,53-57H2,1-6H3,(H,91,105)(H,93,102)(H,94,104)/t59-,67+,69+,74-,79+,84?/m0/s1","UQQFHLGCSOEWFT-SPQPUINASA-N"
"3220","P10415","BCL2","VHL","","753a","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(C[C@@]4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","1.32","Ki was tested by AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81-/m0/s1","KQEMZZJSHJCPSI-UQSQCHHSSA-N"
"3220","Q07817","BCL-xL","VHL","","753a","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(C[C@@]4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","1.52","Ki was tested by AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81-/m0/s1","KQEMZZJSHJCPSI-UQSQCHHSSA-N"
"3221","P10415","BCL2","VHL","","753b","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(C[C@]4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","48","","Degradation of BCL2 in 293T cells after 16 h treatment","","","","","","","","","1.054","Ki was tested by AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81+/m0/s1","KQEMZZJSHJCPSI-RYFXIQSLSA-N"
"3221","Q07817","BCL-xL","VHL","","753b","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)N3CCN(C[C@]4(C)CCC(C5=CC=C(Cl)C=C5)=C(CN5CCN(C6=CC=C(C(=O)NS(=O)(=O)C7=CC=C(N[C@H](CCN8CCOCC8)CSC8=CC=CC=C8)C(S(=O)(=O)C(F)(F)F)=C7)C=C6)CC5)C4)CC3)C(C)(C)C)C=C2)SC=N1","6","","Degradation of BCL-xL in 293T cells after 16 h treatment","","","","","","","","","1.313","Ki was tested by AlphaScreen assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1038/s41467-021-27210-x","1641.523","1639.65184952","12.31","112","11","19","5","31","263.54","C82H105ClF3N11O11S4","InChI=1S/C82H105ClF3N11O11S4/c1-56(58-18-20-60(21-19-58)75-57(2)87-55-110-75)88-78(102)71-48-66(98)52-97(71)79(103)76(80(3,4)5)90-73(99)16-12-7-8-13-17-74(100)96-42-38-94(39-43-96)54-81(6)34-32-69(59-22-26-63(83)27-23-59)62(50-81)51-93-36-40-95(41-37-93)65-28-24-61(25-29-65)77(101)91-112(106,107)68-30-31-70(72(49-68)111(104,105)82(84,85)86)89-64(33-35-92-44-46-108-47-45-92)53-109-67-14-10-9-11-15-67/h9-11,14-15,18-31,49,55-56,64,66,71,76,89,98H,7-8,12-13,16-17,32-48,50-54H2,1-6H3,(H,88,102)(H,90,99)(H,91,101)/t56-,64+,66+,71-,76+,81+/m0/s1","KQEMZZJSHJCPSI-RYFXIQSLSA-N"
"3222","Q13547","HDAC1","CRBN","","","O=C(CCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","2310","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","416.434","416.169584488","-0.7","30","3","6","4","8","144.91","C20H24N4O6","InChI=1S/C20H24N4O6/c25-16(7-2-1-3-8-18(27)23-30)21-14-6-4-5-12-13(14)11-24(20(12)29)15-9-10-17(26)22-19(15)28/h4-6,15,30H,1-3,7-11H2,(H,21,25)(H,23,27)(H,22,26,28)","YVJMSYYKBQTJNZ-UHFFFAOYSA-N"
"3222","O15379","HDAC3","CRBN","","","O=C(CCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","2200","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","416.434","416.169584488","-0.7","30","3","6","4","8","144.91","C20H24N4O6","InChI=1S/C20H24N4O6/c25-16(7-2-1-3-8-18(27)23-30)21-14-6-4-5-12-13(14)11-24(20(12)29)15-9-10-17(26)22-19(15)28/h4-6,15,30H,1-3,7-11H2,(H,21,25)(H,23,27)(H,22,26,28)","YVJMSYYKBQTJNZ-UHFFFAOYSA-N"
"3222","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","1980","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","416.434","416.169584488","-0.7","30","3","6","4","8","144.91","C20H24N4O6","InChI=1S/C20H24N4O6/c25-16(7-2-1-3-8-18(27)23-30)21-14-6-4-5-12-13(14)11-24(20(12)29)15-9-10-17(26)22-19(15)28/h4-6,15,30H,1-3,7-11H2,(H,21,25)(H,23,27)(H,22,26,28)","YVJMSYYKBQTJNZ-UHFFFAOYSA-N"
"3223","Q13547","HDAC1","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","380","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","430.461","430.185234552","-0.15","31","3","6","4","9","144.91","C21H26N4O6","InChI=1S/C21H26N4O6/c26-17(8-3-1-2-4-9-19(28)24-31)22-15-7-5-6-13-14(15)12-25(21(13)30)16-10-11-18(27)23-20(16)29/h5-7,16,31H,1-4,8-12H2,(H,22,26)(H,24,28)(H,23,27,29)","NBFLVVBMRTZBEB-UHFFFAOYSA-N"
"3223","O15379","HDAC3","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","470","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","430.461","430.185234552","-0.15","31","3","6","4","9","144.91","C21H26N4O6","InChI=1S/C21H26N4O6/c26-17(8-3-1-2-4-9-19(28)24-31)22-15-7-5-6-13-14(15)12-25(21(13)30)16-10-11-18(27)23-20(16)29/h5-7,16,31H,1-4,8-12H2,(H,22,26)(H,24,28)(H,23,27,29)","NBFLVVBMRTZBEB-UHFFFAOYSA-N"
"3223","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","1460","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","430.461","430.185234552","-0.15","31","3","6","4","9","144.91","C21H26N4O6","InChI=1S/C21H26N4O6/c26-17(8-3-1-2-4-9-19(28)24-31)22-15-7-5-6-13-14(15)12-25(21(13)30)16-10-11-18(27)23-20(16)29/h5-7,16,31H,1-4,8-12H2,(H,22,26)(H,24,28)(H,23,27,29)","NBFLVVBMRTZBEB-UHFFFAOYSA-N"
"3224","Q13547","HDAC1","CRBN","","","O=C(CCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","1130","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","444.488","444.200884616","0.39","32","3","6","4","10","144.91","C22H28N4O6","InChI=1S/C22H28N4O6/c27-18(9-4-2-1-3-5-10-20(29)25-32)23-16-8-6-7-14-15(16)13-26(22(14)31)17-11-12-19(28)24-21(17)30/h6-8,17,32H,1-5,9-13H2,(H,23,27)(H,25,29)(H,24,28,30)","FEQBAPFWBUXUOT-UHFFFAOYSA-N"
"3224","O15379","HDAC3","CRBN","","","O=C(CCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","1060","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","444.488","444.200884616","0.39","32","3","6","4","10","144.91","C22H28N4O6","InChI=1S/C22H28N4O6/c27-18(9-4-2-1-3-5-10-20(29)25-32)23-16-8-6-7-14-15(16)13-26(22(14)31)17-11-12-19(28)24-21(17)30/h6-8,17,32H,1-5,9-13H2,(H,23,27)(H,25,29)(H,24,28,30)","FEQBAPFWBUXUOT-UHFFFAOYSA-N"
"3224","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","3670","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","444.488","444.200884616","0.39","32","3","6","4","10","144.91","C22H28N4O6","InChI=1S/C22H28N4O6/c27-18(9-4-2-1-3-5-10-20(29)25-32)23-16-8-6-7-14-15(16)13-26(22(14)31)17-11-12-19(28)24-21(17)30/h6-8,17,32H,1-5,9-13H2,(H,23,27)(H,25,29)(H,24,28,30)","FEQBAPFWBUXUOT-UHFFFAOYSA-N"
"3225","Q13547","HDAC1","CRBN","","","O=C(CCCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","720","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","458.515","458.21653468","0.93","33","3","6","4","11","144.91","C23H30N4O6","InChI=1S/C23H30N4O6/c28-19(10-5-3-1-2-4-6-11-21(30)26-33)24-17-9-7-8-15-16(17)14-27(23(15)32)18-12-13-20(29)25-22(18)31/h7-9,18,33H,1-6,10-14H2,(H,24,28)(H,26,30)(H,25,29,31)","FWPNOUQIZJNUJP-UHFFFAOYSA-N"
"3225","O15379","HDAC3","CRBN","","","O=C(CCCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","750","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","458.515","458.21653468","0.93","33","3","6","4","11","144.91","C23H30N4O6","InChI=1S/C23H30N4O6/c28-19(10-5-3-1-2-4-6-11-21(30)26-33)24-17-9-7-8-15-16(17)14-27(23(15)32)18-12-13-20(29)25-22(18)31/h7-9,18,33H,1-6,10-14H2,(H,24,28)(H,26,30)(H,25,29,31)","FWPNOUQIZJNUJP-UHFFFAOYSA-N"
"3225","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCCCC(=O)NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O)NO","","","","","","2940","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules26237241","458.515","458.21653468","0.93","33","3","6","4","11","144.91","C23H30N4O6","InChI=1S/C23H30N4O6/c28-19(10-5-3-1-2-4-6-11-21(30)26-33)24-17-9-7-8-15-16(17)14-27(23(15)32)18-12-13-20(29)25-22(18)31/h7-9,18,33H,1-6,10-14H2,(H,24,28)(H,26,30)(H,25,29,31)","FWPNOUQIZJNUJP-UHFFFAOYSA-N"
"3226","Q13547","HDAC1","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NO","","","","","","2700","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","444.444","444.164499108","0.55","32","3","7","4","9","161.98","C21H24N4O7","InChI=1S/C21H24N4O7/c26-15(8-3-1-2-4-9-17(28)24-32)22-13-7-5-6-12-18(13)21(31)25(20(12)30)14-10-11-16(27)23-19(14)29/h5-7,14,32H,1-4,8-11H2,(H,22,26)(H,24,28)(H,23,27,29)","PRSFCRQNQVGPGL-UHFFFAOYSA-N"
"3226","O15379","HDAC3","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NO","","","","","","330","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","444.444","444.164499108","0.55","32","3","7","4","9","161.98","C21H24N4O7","InChI=1S/C21H24N4O7/c26-15(8-3-1-2-4-9-17(28)24-32)22-13-7-5-6-12-18(13)21(31)25(20(12)30)14-10-11-16(27)23-19(14)29/h5-7,14,32H,1-4,8-11H2,(H,22,26)(H,24,28)(H,23,27,29)","PRSFCRQNQVGPGL-UHFFFAOYSA-N"
"3226","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCCC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NO","","","","","","420","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","444.444","444.164499108","0.55","32","3","7","4","9","161.98","C21H24N4O7","InChI=1S/C21H24N4O7/c26-15(8-3-1-2-4-9-17(28)24-32)22-13-7-5-6-12-18(13)21(31)25(20(12)30)14-10-11-16(27)23-19(14)29/h5-7,14,32H,1-4,8-11H2,(H,22,26)(H,24,28)(H,23,27,29)","PRSFCRQNQVGPGL-UHFFFAOYSA-N"
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"3230","O15379","HDAC3","CRBN","","","O=C(CCCCCNC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NO","","","","","","220","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","445.432","445.159748076","-0.49","32","3","7","5","8","174.01","C20H23N5O7","InChI=1S/C20H23N5O7/c26-14-9-8-13(17(28)23-14)25-18(29)11-5-4-6-12(16(11)19(25)30)22-20(31)21-10-3-1-2-7-15(27)24-32/h4-6,13,32H,1-3,7-10H2,(H,24,27)(H2,21,22,31)(H,23,26,28)","KNGUNHPHYALYKS-UHFFFAOYSA-N"
"3230","Q9UBN7","HDAC6","CRBN","","","O=C(CCCCCNC(=O)NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NO","","","","","","5280","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","445.432","445.159748076","-0.49","32","3","7","5","8","174.01","C20H23N5O7","InChI=1S/C20H23N5O7/c26-14-9-8-13(17(28)23-14)25-18(29)11-5-4-6-12(16(11)19(25)30)22-20(31)21-10-3-1-2-7-15(27)24-32/h4-6,13,32H,1-3,7-10H2,(H,24,27)(H2,21,22,31)(H,23,26,28)","KNGUNHPHYALYKS-UHFFFAOYSA-N"
"3231","Q13547","HDAC1","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","1600","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","484.512","484.174669868","1.8","36","5","6","3","6","130.83","C27H24N4O5","InChI=1S/C27H24N4O5/c28-20-5-1-2-6-21(20)29-25(33)17-10-8-16(9-11-17)15-36-23-7-3-4-18-19(23)14-31(27(18)35)22-12-13-24(32)30-26(22)34/h1-11,22H,12-15,28H2,(H,29,33)(H,30,32,34)","RDQXAQYEABCNQH-UHFFFAOYSA-N"
"3231","O15379","HDAC3","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","560","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","484.512","484.174669868","1.8","36","5","6","3","6","130.83","C27H24N4O5","InChI=1S/C27H24N4O5/c28-20-5-1-2-6-21(20)29-25(33)17-10-8-16(9-11-17)15-36-23-7-3-4-18-19(23)14-31(27(18)35)22-12-13-24(32)30-26(22)34/h1-11,22H,12-15,28H2,(H,29,33)(H,30,32,34)","RDQXAQYEABCNQH-UHFFFAOYSA-N"
"3231","Q9UBN7","HDAC6","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2CN(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","",">20000","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","43","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","484.512","484.174669868","1.8","36","5","6","3","6","130.83","C27H24N4O5","InChI=1S/C27H24N4O5/c28-20-5-1-2-6-21(20)29-25(33)17-10-8-16(9-11-17)15-36-23-7-3-4-18-19(23)14-31(27(18)35)22-12-13-24(32)30-26(22)34/h1-11,22H,12-15,28H2,(H,29,33)(H,30,32,34)","RDQXAQYEABCNQH-UHFFFAOYSA-N"
"3232","Q13547","HDAC1","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","1200","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","541","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","498.495","498.153934424","1.74","37","5","7","3","6","147.9","C27H22N4O6","InChI=1S/C27H22N4O6/c28-18-5-1-2-6-19(18)29-24(33)16-10-8-15(9-11-16)14-37-21-7-3-4-17-23(21)27(36)31(26(17)35)20-12-13-22(32)30-25(20)34/h1-11,20H,12-14,28H2,(H,29,33)(H,30,32,34)","BAMHDTFTYJNQJI-UHFFFAOYSA-N"
"3232","O15379","HDAC3","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","","280","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","541","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","498.495","498.153934424","1.74","37","5","7","3","6","147.9","C27H22N4O6","InChI=1S/C27H22N4O6/c28-18-5-1-2-6-19(18)29-24(33)16-10-8-15(9-11-16)14-37-21-7-3-4-17-23(21)27(36)31(26(17)35)20-12-13-22(32)30-25(20)34/h1-11,20H,12-14,28H2,(H,29,33)(H,30,32,34)","BAMHDTFTYJNQJI-UHFFFAOYSA-N"
"3232","Q9UBN7","HDAC6","CRBN","","","NC1=CC=CC=C1NC(=O)C1=CC=C(COC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)C=C1","","","","","",">20000","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","541","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","498.495","498.153934424","1.74","37","5","7","3","6","147.9","C27H22N4O6","InChI=1S/C27H22N4O6/c28-18-5-1-2-6-19(18)29-24(33)16-10-8-15(9-11-16)14-37-21-7-3-4-17-23(21)27(36)31(26(17)35)20-12-13-22(32)30-25(20)34/h1-11,20H,12-14,28H2,(H,29,33)(H,30,32,34)","BAMHDTFTYJNQJI-UHFFFAOYSA-N"
"3233","Q13547","HDAC1","CRBN","","","O=C1CCC(N2CC3=C(OCC4=CC=C(C(=O)NO)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","8320","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","409.398","409.127385328","0.43","30","4","6","3","5","125.04","C21H19N3O6","InChI=1S/C21H19N3O6/c25-18-9-8-16(20(27)22-18)24-10-15-14(21(24)28)2-1-3-17(15)30-11-12-4-6-13(7-5-12)19(26)23-29/h1-7,16,29H,8-11H2,(H,23,26)(H,22,25,27)","BKKKUAHCAQVVDE-UHFFFAOYSA-N"
"3233","O15379","HDAC3","CRBN","","","O=C1CCC(N2CC3=C(OCC4=CC=C(C(=O)NO)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","650","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","409.398","409.127385328","0.43","30","4","6","3","5","125.04","C21H19N3O6","InChI=1S/C21H19N3O6/c25-18-9-8-16(20(27)22-18)24-10-15-14(21(24)28)2-1-3-17(15)30-11-12-4-6-13(7-5-12)19(26)23-29/h1-7,16,29H,8-11H2,(H,23,26)(H,22,25,27)","BKKKUAHCAQVVDE-UHFFFAOYSA-N"
"3233","Q9UBN7","HDAC6","CRBN","","","O=C1CCC(N2CC3=C(OCC4=CC=C(C(=O)NO)C=C4)C=CC=C3C2=O)C(=O)N1","","","","","","380","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","",">10000","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","409.398","409.127385328","0.43","30","4","6","3","5","125.04","C21H19N3O6","InChI=1S/C21H19N3O6/c25-18-9-8-16(20(27)22-18)24-10-15-14(21(24)28)2-1-3-17(15)30-11-12-4-6-13(7-5-12)19(26)23-29/h1-7,16,29H,8-11H2,(H,23,26)(H,22,25,27)","BKKKUAHCAQVVDE-UHFFFAOYSA-N"
"3234","Q13547","HDAC1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(OCC4=CC=C(C(=O)NO)C=C4)=C3C2=O)C(=O)N1","","","","","","2230","Inhibition of HDAC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1340","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","423.381","423.106649884","0.38","31","4","7","3","5","142.11","C21H17N3O7","InChI=1S/C21H17N3O7/c25-16-9-8-14(19(27)22-16)24-20(28)13-2-1-3-15(17(13)21(24)29)31-10-11-4-6-12(7-5-11)18(26)23-30/h1-7,14,30H,8-10H2,(H,23,26)(H,22,25,27)","VXUMRHPWCPIJBD-UHFFFAOYSA-N"
"3234","O15379","HDAC3","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(OCC4=CC=C(C(=O)NO)C=C4)=C3C2=O)C(=O)N1","","","","","","760","Inhibition of HDAC3","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1340","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","423.381","423.106649884","0.38","31","4","7","3","5","142.11","C21H17N3O7","InChI=1S/C21H17N3O7/c25-16-9-8-14(19(27)22-16)24-20(28)13-2-1-3-15(17(13)21(24)29)31-10-11-4-6-12(7-5-11)18(26)23-30/h1-7,14,30H,8-10H2,(H,23,26)(H,22,25,27)","VXUMRHPWCPIJBD-UHFFFAOYSA-N"
"3234","Q9UBN7","HDAC6","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(OCC4=CC=C(C(=O)NO)C=C4)=C3C2=O)C(=O)N1","","","","","",">20000","Inhibition of HDAC6","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","1340","Inhibit proliferation of MM.1S cells","","","","","","","","","","","","","","","10.3390/molecules26237241","423.381","423.106649884","0.38","31","4","7","3","5","142.11","C21H17N3O7","InChI=1S/C21H17N3O7/c25-16-9-8-14(19(27)22-16)24-20(28)13-2-1-3-15(17(13)21(24)29)31-10-11-4-6-12(7-5-11)18(26)23-30/h1-7,14,30H,8-10H2,(H,23,26)(H,22,25,27)","VXUMRHPWCPIJBD-UHFFFAOYSA-N"
"3235","Q00613","HSF1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCCNC4=CC=C([N+](=O)[O-])C(NC5=CC=C6[NH]N=CC6=C5)=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules27051655","597.592","597.208429584","4.21","44","6","11","5","11","204.35","C29H27N9O6","InChI=1S/C29H27N9O6/c39-24-11-9-22(27(40)35-24)37-28(41)18-4-3-5-20(25(18)29(37)42)30-12-1-2-13-31-23-10-8-21(38(43)44)26(34-23)33-17-6-7-19-16(14-17)15-32-36-19/h3-8,10,14-15,22,30H,1-2,9,11-13H2,(H,32,36)(H2,31,33,34)(H,35,39,40)","YVKMEJDKAKQVRH-UHFFFAOYSA-N"
"3236","Q00613","HSF1","CRBN","","","O=C1CCC(N2C(=O)C3=CC=CC(NCCCOCCOCCOCCCNC4=CC=C([N+](=O)[O-])C(NC5=CC=C6[NH]N=CC6=C5)=N4)=C3C2=O)C(=O)N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules27051655","729.751","729.287073828","3.76","53","6","14","5","20","232.04","C35H39N9O9","InChI=1S/C35H39N9O9/c45-30-11-9-28(33(46)41-30)43-34(47)24-4-1-5-26(31(24)35(43)48)36-12-2-14-51-16-18-53-19-17-52-15-3-13-37-29-10-8-27(44(49)50)32(40-29)39-23-6-7-25-22(20-23)21-38-42-25/h1,4-8,10,20-21,28,36H,2-3,9,11-19H2,(H,38,42)(H2,37,39,40)(H,41,45,46)","PDVNODIFSHYYDY-UHFFFAOYSA-N"
"3237","Q00613","HSF1","CRBN","","","O=C(CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCOCCOCCOCCCNC1=CC=C([N+](=O)[O-])C(NC2=CC=C3[NH]N=CC3=C2)=N1","","N.D.","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.3390/molecules27051655","786.803","786.308537544","3.11","57","6","15","6","22","261.14","C37H42N10O10","InChI=1S/C37H42N10O10/c48-31-11-9-29(35(50)44-31)46-36(51)25-4-1-5-27(33(25)37(46)52)40-22-32(49)39-13-3-15-56-17-19-57-18-16-55-14-2-12-38-30-10-8-28(47(53)54)34(43-30)42-24-6-7-26-23(20-24)21-41-45-26/h1,4-8,10,20-21,29,40H,2-3,9,11-19,22H2,(H,39,49)(H,41,45)(H2,38,42,43)(H,44,48,50)","NKXLHCPQTNAKHI-UHFFFAOYSA-N"
"3238","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1198.424","1197.56567874","3.37","85","8","15","6","24","234.11","C61H78F3N11O9S","InChI=1S/C61H78F3N11O9S/c1-40-55(85-39-68-40)43-11-9-41(10-12-43)35-67-58(81)51-33-46(76)38-75(51)59(82)56(60(2,3)4)70-53(78)16-28-84-30-29-83-27-15-52(77)65-17-18-72-21-23-73(24-22-72)37-42-7-6-8-44(31-42)45-13-14-50(74-25-19-71(5)20-26-74)49(32-45)69-57(80)47-36-66-54(79)34-48(47)61(62,63)64/h6-14,31-32,34,36,39,46,51,56,76H,15-30,33,35,37-38H2,1-5H3,(H,65,77)(H,66,79)(H,67,81)(H,69,80)(H,70,78)/t46-,51+,56-/m1/s1","JWNOHPMJVYQKIX-SYXXMXNHSA-N"
"3239","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1242.477","1241.59189348","3.23","88","8","16","6","27","243.34","C63H82F3N11O10S","InChI=1S/C63H82F3N11O10S/c1-42-57(88-41-70-42)45-11-9-43(10-12-45)37-69-60(83)53-35-48(78)40-77(53)61(84)58(62(2,3)4)72-55(80)16-28-86-30-32-87-31-29-85-27-15-54(79)67-17-18-74-21-23-75(24-22-74)39-44-7-6-8-46(33-44)47-13-14-52(76-25-19-73(5)20-26-76)51(34-47)71-59(82)49-38-68-56(81)36-50(49)63(64,65)66/h6-14,33-34,36,38,41,48,53,58,78H,15-32,35,37,39-40H2,1-5H3,(H,67,79)(H,68,81)(H,69,83)(H,71,82)(H,72,80)/t48-,53+,58-/m1/s1","UDIKIPMRVVYFFA-KTYBHKGASA-N"
"3240","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1286.53","1285.61810823","3.08","91","8","17","6","30","252.57","C65H86F3N11O11S","InChI=1S/C65H86F3N11O11S/c1-44-59(91-43-72-44)47-11-9-45(10-12-47)39-71-62(85)55-37-50(80)42-79(55)63(86)60(64(2,3)4)74-57(82)16-28-88-30-32-90-34-33-89-31-29-87-27-15-56(81)69-17-18-76-21-23-77(24-22-76)41-46-7-6-8-48(35-46)49-13-14-54(78-25-19-75(5)20-26-78)53(36-49)73-61(84)51-40-70-58(83)38-52(51)65(66,67)68/h6-14,35-36,38,40,43,50,55,60,80H,15-34,37,39,41-42H2,1-5H3,(H,69,81)(H,70,83)(H,71,85)(H,73,84)(H,74,82)/t50-,55+,60-/m1/s1","RSBJQQIVZXVMRO-LCLGPXMOSA-N"
"3241","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1330.583","1329.64432298","2.93","94","8","18","6","33","261.8","C67H90F3N11O12S","InChI=1S/C67H90F3N11O12S/c1-46-61(94-45-74-46)49-11-9-47(10-12-49)41-73-64(87)57-39-52(82)44-81(57)65(88)62(66(2,3)4)76-59(84)16-28-90-30-32-92-34-36-93-35-33-91-31-29-89-27-15-58(83)71-17-18-78-21-23-79(24-22-78)43-48-7-6-8-50(37-48)51-13-14-56(80-25-19-77(5)20-26-80)55(38-51)75-63(86)53-42-72-60(85)40-54(53)67(68,69)70/h6-14,37-38,40,42,45,52,57,62,82H,15-36,39,41,43-44H2,1-5H3,(H,71,83)(H,72,85)(H,73,87)(H,75,86)(H,76,84)/t52-,57+,62-/m1/s1","AAFBROZXFJRJFC-QNIQEMAOSA-N"
"3242","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1166.426","1165.5758495","5.47","83","8","13","6","22","215.65","C61H78F3N11O7S","InChI=1S/C61H78F3N11O7S/c1-40-55(83-39-68-40)43-17-15-41(16-18-43)35-67-58(81)51-33-46(76)38-75(51)59(82)56(60(2,3)4)70-53(78)14-9-7-6-8-13-52(77)65-21-22-72-25-27-73(28-26-72)37-42-11-10-12-44(31-42)45-19-20-50(74-29-23-71(5)24-30-74)49(32-45)69-57(80)47-36-66-54(79)34-48(47)61(62,63)64/h10-12,15-20,31-32,34,36,39,46,51,56,76H,6-9,13-14,21-30,33,35,37-38H2,1-5H3,(H,65,77)(H,66,79)(H,67,81)(H,69,80)(H,70,78)/t46-,51+,56-/m1/s1","AZKHNVFQIUJOPX-SYXXMXNHSA-N"
"3243","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1180.453","1179.59149956","6.01","84","8","13","6","23","215.65","C62H80F3N11O7S","InChI=1S/C62H80F3N11O7S/c1-41-56(84-40-69-41)44-18-16-42(17-19-44)36-68-59(82)52-34-47(77)39-76(52)60(83)57(61(2,3)4)71-54(79)15-10-8-6-7-9-14-53(78)66-22-23-73-26-28-74(29-27-73)38-43-12-11-13-45(32-43)46-20-21-51(75-30-24-72(5)25-31-75)50(33-46)70-58(81)48-37-67-55(80)35-49(48)62(63,64)65/h11-13,16-21,32-33,35,37,40,47,52,57,77H,6-10,14-15,22-31,34,36,38-39H2,1-5H3,(H,66,78)(H,67,80)(H,68,82)(H,70,81)(H,71,79)/t47-,52+,57-/m1/s1","XHIYCVGFYCMOCK-FVWZZRJKSA-N"
"3244","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1194.48","1193.60714962","6.55","85","8","13","6","24","215.65","C63H82F3N11O7S","InChI=1S/C63H82F3N11O7S/c1-42-57(85-41-70-42)45-19-17-43(18-20-45)37-69-60(83)53-35-48(78)40-77(53)61(84)58(62(2,3)4)72-55(80)16-11-9-7-6-8-10-15-54(79)67-23-24-74-27-29-75(30-28-74)39-44-13-12-14-46(33-44)47-21-22-52(76-31-25-73(5)26-32-76)51(34-47)71-59(82)49-38-68-56(81)36-50(49)63(64,65)66/h12-14,17-22,33-34,36,38,41,48,53,58,78H,6-11,15-16,23-32,35,37,39-40H2,1-5H3,(H,67,79)(H,68,81)(H,69,83)(H,71,82)(H,72,80)/t48-,53+,58-/m1/s1","WJMJKBZBSNKBEY-KTYBHKGASA-N"
"3245","P61964","WDR5","VHL","7JTO","MS33","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","260","71","Degradation of WDR5 in MV4;11 cells after 18 h treatment","","","","","","","120","ITC","","","","","","","","","","","","","","","870","ITC","","","","","","","","","","","","","","","520","Kd between VHL and the complex of protac and WDR5 was tested by ITC","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1208.507","1207.62279969","7.09","86","8","13","6","25","215.65","C64H84F3N11O7S","InChI=1S/C64H84F3N11O7S/c1-43-58(86-42-71-43)46-20-18-44(19-21-46)38-70-61(84)54-36-49(79)41-78(54)62(85)59(63(2,3)4)73-56(81)17-12-10-8-6-7-9-11-16-55(80)68-24-25-75-28-30-76(31-29-75)40-45-14-13-15-47(34-45)48-22-23-53(77-32-26-74(5)27-33-77)52(35-48)72-60(83)50-39-69-57(82)37-51(50)64(65,66)67/h13-15,18-23,34-35,37,39,42,49,54,59,79H,6-12,16-17,24-33,36,38,40-41H2,1-5H3,(H,68,80)(H,69,82)(H,70,84)(H,72,83)(H,73,81)/t49-,54+,59-/m1/s1","GLYGYEQLMMPSAW-QWQPEEPRSA-N"
"3246","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCCN3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1222.534","1221.63844975","7.63","87","8","13","6","26","215.65","C65H86F3N11O7S","InChI=1S/C65H86F3N11O7S/c1-44-59(87-43-72-44)47-21-19-45(20-22-47)39-71-62(85)55-37-50(80)42-79(55)63(86)60(64(2,3)4)74-57(82)18-13-11-9-7-6-8-10-12-17-56(81)69-25-26-76-29-31-77(32-30-76)41-46-15-14-16-48(35-46)49-23-24-54(78-33-27-75(5)28-34-78)53(36-49)73-61(84)51-40-70-58(83)38-52(51)65(66,67)68/h14-16,19-24,35-36,38,40,43,50,55,60,80H,6-13,17-18,25-34,37,39,41-42H2,1-5H3,(H,69,81)(H,70,83)(H,71,85)(H,73,84)(H,74,82)/t50-,55+,60-/m1/s1","PRAKQPWJRGIEML-LCLGPXMOSA-N"
"3247","P61964","WDR5","CRBN","","","CN1CCN(C2=CC=C(C3=CC=CC(CN4CCN(CCNC(=O)CCCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C3)C=C2NC(=O)C2=C[NH]C(=O)C=C2C(F)(F)F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","953.036","952.42072876","2.8","69","8","12","5","16","199.6","C49H55F3N10O7","InChI=1S/C49H55F3N10O7/c1-58-18-24-61(25-19-58)39-12-11-33(27-38(39)56-45(66)35-29-55-43(65)28-36(35)49(50,51)52)32-7-4-6-31(26-32)30-60-22-20-59(21-23-60)17-16-54-41(63)10-2-3-15-53-37-9-5-8-34-44(37)48(69)62(47(34)68)40-13-14-42(64)57-46(40)67/h4-9,11-12,26-29,40,53H,2-3,10,13-25,30H2,1H3,(H,54,63)(H,55,65)(H,56,66)(H,57,64,67)","NVVCHFULRVYGAD-UHFFFAOYSA-N"
"3248","P61964","WDR5","CRBN","","","CN1CCN(C2=CC=C(C3=CC=CC(CN4CCN(CCNC(=O)CCOCCOCCOCCOCCNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)=C3)C=C2NC(=O)C2=C[NH]C(=O)C=C2C(F)(F)F)CC1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1101.194","1100.49428762","1.5","79","8","16","5","26","236.52","C55H67F3N10O11","InChI=1S/C55H67F3N10O11/c1-64-16-22-67(23-17-64)45-9-8-39(33-44(45)62-51(72)41-35-61-49(71)34-42(41)55(56,57)58)38-5-2-4-37(32-38)36-66-20-18-65(19-21-66)15-13-60-47(69)12-24-76-26-28-78-30-31-79-29-27-77-25-14-59-43-7-3-6-40-50(43)54(75)68(53(40)74)46-10-11-48(70)63-52(46)73/h2-9,32-35,46,59H,10-31,36H2,1H3,(H,60,69)(H,61,71)(H,62,72)(H,63,70,73)","SMLMEQWGVJQABP-UHFFFAOYSA-N"
"3249","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CCC(=O)N3CCN(CC4=CC=CC(C5=CC=C(N6CCN(C)CC6)C(NC(=O)C6=C[NH]C(=O)C=C6C(F)(F)F)=C5)=C4)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1067.249","1066.47105008","3.81","76","8","12","5","15","203.62","C55H65F3N10O7S","InChI=1S/C55H65F3N10O7S/c1-34-49(76-33-61-34)37-11-9-35(10-12-37)29-60-52(74)45-27-40(69)32-68(45)53(75)50(54(2,3)4)63-46(70)15-16-48(72)67-23-19-65(20-24-67)31-36-7-6-8-38(25-36)39-13-14-44(66-21-17-64(5)18-22-66)43(26-39)62-51(73)41-30-59-47(71)28-42(41)55(56,57)58/h6-14,25-26,28,30,33,40,45,50,69H,15-24,27,29,31-32H2,1-5H3,(H,59,71)(H,60,74)(H,62,73)(H,63,70)/t40-,45+,50-/m1/s1","GFCFZLPKBSGAHU-SHPBXJAASA-N"
"3250","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=CC(C4=CC=C(N5CCN(C)CC5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","970.088","969.381900728","4.15","69","7","11","6","13","209.17","C49H54F3N9O7S","InChI=1S/C49H54F3N9O7S/c1-28-42(69-27-56-28)30-11-9-29(10-12-30)23-54-46(67)39-21-34(62)26-61(39)47(68)43(48(2,3)4)58-41(64)25-55-44(65)33-8-6-7-31(19-33)32-13-14-38(60-17-15-59(5)16-18-60)37(20-32)57-45(66)35-24-53-40(63)22-36(35)49(50,51)52/h6-14,19-20,22,24,27,34,39,43,62H,15-18,21,23,25-26H2,1-5H3,(H,53,63)(H,54,67)(H,55,65)(H,57,66)(H,58,64)/t34-,39+,43-/m1/s1","BUCDOWRSLBETLB-SQKKEFIPSA-N"
"3251","P61964","WDR5","VHL","","","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=CC(C4=CC=C(N5CCN(C)CC5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","984.115","983.397550792","4.55","70","7","11","6","13","209.17","C50H56F3N9O7S","InChI=1S/C50H56F3N9O7S/c1-28(30-10-12-31(13-11-30)43-29(2)56-27-70-43)57-47(68)40-22-35(63)26-62(40)48(69)44(49(3,4)5)59-42(65)25-55-45(66)34-9-7-8-32(20-34)33-14-15-39(61-18-16-60(6)17-19-61)38(21-33)58-46(67)36-24-54-41(64)23-37(36)50(51,52)53/h7-15,20-21,23-24,27-28,35,40,44,63H,16-19,22,25-26H2,1-6H3,(H,54,64)(H,55,66)(H,57,68)(H,58,67)(H,59,65)/t28-,35+,40-,44+/m0/s1","QXYCIZQQMFNEIR-BABAJCCMSA-N"
"3252","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=C(F)C(C4=CC=C(N5CCN(C)CC5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","988.078","987.372478916","4.25","70","7","11","6","13","209.17","C49H53F4N9O7S","InChI=1S/C49H53F4N9O7S/c1-27-42(70-26-57-27)29-8-6-28(7-9-29)22-55-46(68)39-20-32(63)25-62(39)47(69)43(48(2,3)4)59-41(65)24-56-44(66)31-10-12-36(50)33(18-31)30-11-13-38(61-16-14-60(5)15-17-61)37(19-30)58-45(67)34-23-54-40(64)21-35(34)49(51,52)53/h6-13,18-19,21,23,26,32,39,43,63H,14-17,20,22,24-25H2,1-5H3,(H,54,64)(H,55,68)(H,56,66)(H,58,67)(H,59,65)/t32-,39+,43-/m1/s1","NOAIKVKPSCMNHB-SQVUQSAVSA-N"
"3253","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=CC(C4=CC=C(N5C[C@H](C)N(C)[C@H](C)C5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","998.142","997.413200856","5.01","71","7","11","6","13","209.17","C51H58F3N9O7S","InChI=1S/C51H58F3N9O7S/c1-28-24-62(25-29(2)61(28)7)40-16-15-34(18-39(40)59-47(68)37-22-55-42(65)20-38(37)51(52,53)54)33-9-8-10-35(17-33)46(67)57-23-43(66)60-45(50(4,5)6)49(70)63-26-36(64)19-41(63)48(69)56-21-31-11-13-32(14-12-31)44-30(3)58-27-71-44/h8-18,20,22,27-29,36,41,45,64H,19,21,23-26H2,1-7H3,(H,55,65)(H,56,69)(H,57,67)(H,59,68)(H,60,66)/t28-,29+,36-,41+,45-/m1/s1","LFOJIXXRRBDBSV-MBBFMUIHSA-N"
"3254","P61964","WDR5","VHL","","","CC1=C(C2=CC=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=C(F)C(C4=CC=C(N5C[C@H](C)N(C)[C@H](C)C5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1126/scitranslmed.abj1578","1016.132","1015.40377904","5.11","72","7","11","6","13","209.17","C51H57F4N9O7S","InChI=1S/C51H57F4N9O7S/c1-27-23-63(24-28(2)62(27)7)40-15-13-32(17-39(40)60-47(69)36-21-56-42(66)19-37(36)51(53,54)55)35-16-33(12-14-38(35)52)46(68)58-22-43(67)61-45(50(4,5)6)49(71)64-25-34(65)18-41(64)48(70)57-20-30-8-10-31(11-9-30)44-29(3)59-26-72-44/h8-17,19,21,26-28,34,41,45,65H,18,20,22-25H2,1-7H3,(H,56,66)(H,57,70)(H,58,68)(H,60,69)(H,61,67)/t27-,28+,34-,41+,45-/m1/s1","OJCYPKZNPSJLGY-KQNJQULYSA-N"
"3255","P61964","WDR5","VHL","7JTP","MS67","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CNC(=O)C3=CC=C(F)C(C4=CC=C(N5C[C@H](C)N(C)[C@H](C)C5)C(NC(=O)C5=C[NH]C(=O)C=C5C(F)(F)F)=C4)=C3)C(C)(C)C)C=C2)SC=N1","3.7/45","94/85","Degradation of WDR5 in MV4;11/MIA PaCa-2 cells after 18 h treatment","","","","","","","63","ITC","","","","","","","","","","","","","","","140","ITC","","","","","","","","","","","","","","","52","Kd between VHL and the complex of protac and WDR5 was tested by ITC","","","","","","","","","","","","","","","15/38/110","Inhibit growth of MV4;11/EOL-1/MOLM13 cells","","","","","","","","","","","10.1126/scitranslmed.abj1578","1030.159","1029.41942911","5.52","73","7","11","6","13","209.17","C52H59F4N9O7S","InChI=1S/C52H59F4N9O7S/c1-27-23-64(24-28(2)63(27)8)41-16-14-33(18-40(41)61-48(70)37-21-57-43(67)20-38(37)52(54,55)56)36-17-34(13-15-39(36)53)47(69)58-22-44(68)62-46(51(5,6)7)50(72)65-25-35(66)19-42(65)49(71)60-29(3)31-9-11-32(12-10-31)45-30(4)59-26-73-45/h9-18,20-21,26-29,35,42,46,66H,19,22-25H2,1-8H3,(H,57,67)(H,58,69)(H,60,71)(H,61,70)(H,62,68)/t27-,28+,29-,35+,42-,46+/m0/s1","HBHSDSLZXDASLT-FLKKWHKHSA-N"
"3256","P10636","Tau","VHL","","C004019","CC(=O)N1CCCN(C2=NC(NCCC3=CC=CS3)=NC(N(C)CC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@@H](O)C[C@@H]3C(=O)NCC3=CC=C(C4=C(C)N=CS4)C=C3)C(C)(C)C)=N2)CC1","7.85","","Degradation of Tau5 in HEK293-hTau cells after 24 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.7150/thno.55680","1035.308","1034.48301382","3.52","72","6","18","5","25","245.91","C49H70N12O9S2","InChI=1S/C49H70N12O9S2/c1-33-42(72-32-53-33)36-12-10-35(11-13-36)28-52-44(66)39-27-37(63)29-61(39)45(67)43(49(3,4)5)54-41(65)31-70-25-24-69-23-22-68-21-16-50-40(64)30-58(6)47-55-46(51-15-14-38-9-7-26-71-38)56-48(57-47)60-18-8-17-59(19-20-60)34(2)62/h7,9-13,26,32,37,39,43,63H,8,14-25,27-31H2,1-6H3,(H,50,64)(H,52,66)(H,54,65)(H,51,55,56,57)/t37-,39+,43+/m0/s1","IXTMPMLKABNFTQ-LLIFGLRNSA-N"
"3257","P11802","CDK4","CRBN","","MS140","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","0.38","Inhibition of CDK4/cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4/45/25","Inhibit growth of Mino/MOLM14/MV4;11 cells","","","","","","","","","","","10.1038/s43018-021-00174-z","760.812","760.30814362","2.21","56","8","14","3","9","208.9","C39H40N10O7","InChI=1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45)","IWFNIKIERKCKFZ-UHFFFAOYSA-N"
"3257","Q00534","CDK6","CRBN","","MS140","CC(=O)C1=C(C)C2=CN=C(NC3=CC=C(N4CCN(C(=O)CNC5=CC=CC6=C5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)C=N3)N=C2N(C2CCCC2)C1=O","","","","","","0.28","Inhibition of CDK6/cyclin D1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","4/45/25","Inhibit growth of Mino/MOLM14/MV4;11 cells","","","","","","","","","","","10.1038/s43018-021-00174-z","760.812","760.30814362","2.21","56","8","14","3","9","208.9","C39H40N10O7","InChI=1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45)","IWFNIKIERKCKFZ-UHFFFAOYSA-N"
"3258","P51531","SMARCA2","VHL","","AU-15330","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CN3CCN(C4=CC(C5=CC=CC=C5O)=NN=C4N)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19.49/9.971/4.351","Inhibit viability of LNCaP/VCaP/NCI-H929","","","","","","","","","","","","","","","10.1038/s41586-021-04246-z","755.946","755.357736668","3.25","54","6","12","5","10","190.14","C39H49N9O5S","InChI=1S/C39H49N9O5S/c1-23(25-10-12-26(13-11-25)34-24(2)41-22-54-34)42-37(52)31-18-27(49)20-48(31)38(53)35(39(3,4)5)43-33(51)21-46-14-16-47(17-15-46)30-19-29(44-45-36(30)40)28-8-6-7-9-32(28)50/h6-13,19,22-23,27,31,35,49-50H,14-18,20-21H2,1-5H3,(H2,40,45)(H,42,52)(H,43,51)/t23-,27+,31-,35+/m0/s1","HDCCMCFIGHIDJR-TUDDPRDOSA-N"
"3258","P51532","SMARCA4","VHL","","AU-15330","CC1=C(C2=CC=C([C@H](C)NC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H](NC(=O)CN3CCN(C4=CC(C5=CC=CC=C5O)=NN=C4N)CC3)C(C)(C)C)C=C2)SC=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","19.49/9.971/4.351","Inhibit viability of LNCaP/VCaP/NCI-H929","","","","","","","","","","","","","","","10.1038/s41586-021-04246-z","755.946","755.357736668","3.25","54","6","12","5","10","190.14","C39H49N9O5S","InChI=1S/C39H49N9O5S/c1-23(25-10-12-26(13-11-25)34-24(2)41-22-54-34)42-37(52)31-18-27(49)20-48(31)38(53)35(39(3,4)5)43-33(51)21-46-14-16-47(17-15-46)30-19-29(44-45-36(30)40)28-8-6-7-9-32(28)50/h6-13,19,22-23,27,31,35,49-50H,14-18,20-21H2,1-5H3,(H2,40,45)(H,42,52)(H,43,51)/t23-,27+,31-,35+/m0/s1","HDCCMCFIGHIDJR-TUDDPRDOSA-N"
"3259","Q03111","MLLT1","CRBN","","","C[C@H]1CCCN1CC1=NC2=CC=C(NC(=O)C3=CC=C4C(=C3)C=NN4CCCCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2[NH]1","37","95","Degradation of ENL in MV4;11 cells after 24 h treatment","","","170","Inhibition of ENL YEATS-H3K27ac interaction was tested by an Alpha assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","320/570/1100","Inhibit proliferation of Molm-13/MV4;11/Kasumi-1 cells","","","","","","","","","","","","","10.1186/s13045-022-01258-8","757.896","757.370015604","5.64","56","8","10","4","15","174.42","C42H47N9O5","InChI=1S/C42H47N9O5/c1-26-10-9-20-49(26)25-36-46-31-15-14-29(23-33(31)47-36)45-39(53)27-13-16-34-28(22-27)24-44-50(34)21-7-5-3-2-4-6-19-43-32-12-8-11-30-38(32)42(56)51(41(30)55)35-17-18-37(52)48-40(35)54/h8,11-16,22-24,26,35,43H,2-7,9-10,17-21,25H2,1H3,(H,45,53)(H,46,47)(H,48,52,54)/t26-,35?/m0/s1","SCZWWJDUQGVEMY-HJYWNDIWSA-N"
"3260","Q03111","MLLT1","CRBN","","","C[C@H]1CCCN1CC1=NC2=CC=C(NC(=O)C3=CC=C4C(=C3)C=NN4CCCCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2[NH]1","50","68","Degradation of ENL in MV4;11 cells after 24 h treatment","","","100","Inhibition of ENL YEATS-H3K27ac interaction was tested by an Alpha assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","490/1600/19000","Inhibit proliferation of Molm-13/MV4;11/Kasumi-1 cells","","","","","","","","","","","","","10.1186/s13045-022-01258-8","729.842","729.338715476","4.56","54","8","10","4","13","174.42","C40H43N9O5","InChI=1S/C40H43N9O5/c1-24-8-7-18-47(24)23-34-44-29-13-12-27(21-31(29)45-34)43-37(51)25-11-14-32-26(20-25)22-42-48(32)19-5-3-2-4-17-41-30-10-6-9-28-36(30)40(54)49(39(28)53)33-15-16-35(50)46-38(33)52/h6,9-14,20-22,24,33,41H,2-5,7-8,15-19,23H2,1H3,(H,43,51)(H,44,45)(H,46,50,52)/t24-,33?/m0/s1","PCQKARKEVDFIEV-PPVAYSNCSA-N"
"3261","Q03111","MLLT1","CRBN","","","C[C@H]1CCCN1CC1=NC2=CC=C(NC(=O)C3=CC=C4C(=C3)C=NN4CCCCNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)C=C2[NH]1","72","89","Degradation of ENL in MV4;11 cells after 24 h treatment","","","610","Inhibition of ENL YEATS-H3K27ac interaction was tested by an Alpha assay","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","2100/1200/50000","Inhibit proliferation of Molm-13/MV4;11/Kasumi-1 cells","","","","","","","","","","","","","10.1186/s13045-022-01258-8","701.788","701.307415348","3.85","52","8","10","4","11","174.42","C38H39N9O5","InChI=1S/C38H39N9O5/c1-22-6-5-16-45(22)21-32-42-27-11-10-25(19-29(27)43-32)41-35(49)23-9-12-30-24(18-23)20-40-46(30)17-3-2-15-39-28-8-4-7-26-34(28)38(52)47(37(26)51)31-13-14-33(48)44-36(31)50/h4,7-12,18-20,22,31,39H,2-3,5-6,13-17,21H2,1H3,(H,41,49)(H,42,43)(H,44,48,50)/t22-,31?/m0/s1","BQKBBOYUPLMTRW-DEUJGTPJSA-N"
"3262","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","810","71","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","806.777","805.232841772","3.73","55","6","12","2","15","167.07","C38H41Cl2N9O5S","InChI=1S/C38H41Cl2N9O5S/c1-23-24(2)55-38-35(23)36(26-5-7-27(40)8-6-26)44-29(37-46-45-25(3)49(37)38)20-32(50)42-12-16-53-17-13-43-33(51)22-47-15-18-54-31-19-28(9-10-30(31)47)48(14-4-11-41)34(52)21-39/h5-10,19,29H,4,12-18,20-22H2,1-3H3,(H,42,50)(H,43,51)/t29-/m0/s1","QVNLOGQWJMAEJT-LJAQVGFWSA-N"
"3262","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","820","81","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","806.777","805.232841772","3.73","55","6","12","2","15","167.07","C38H41Cl2N9O5S","InChI=1S/C38H41Cl2N9O5S/c1-23-24(2)55-38-35(23)36(26-5-7-27(40)8-6-26)44-29(37-46-45-25(3)49(37)38)20-32(50)42-12-16-53-17-13-43-33(51)22-47-15-18-54-31-19-28(9-10-30(31)47)48(14-4-11-41)34(52)21-39/h5-10,19,29H,4,12-18,20-22H2,1-3H3,(H,42,50)(H,43,51)/t29-/m0/s1","QVNLOGQWJMAEJT-LJAQVGFWSA-N"
"3263","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","250","94","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","1500","Inhibit FEM1B-FNIP1 degron fluorescence polarization","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","804.805","803.253577216","4.94","55","6","11","2","15","157.84","C39H43Cl2N9O4S","InChI=1S/C39H43Cl2N9O4S/c1-24-25(2)55-39-36(24)37(27-8-10-28(41)11-9-27)45-30(38-47-46-26(3)50(38)39)21-33(51)43-15-5-4-6-16-44-34(52)23-48-18-19-54-32-20-29(12-13-31(32)48)49(17-7-14-42)35(53)22-40/h8-13,20,30H,4-7,15-19,21-23H2,1-3H3,(H,43,51)(H,44,52)/t30-/m0/s1","IEXUFNUFUSSKQI-PMERELPUSA-N"
"3263","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCCCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","198/313","","Degradation of BRD4 in 231MFP/HAP1 cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","804.805","803.253577216","4.94","55","6","11","2","15","157.84","C39H43Cl2N9O4S","InChI=1S/C39H43Cl2N9O4S/c1-24-25(2)55-39-36(24)37(27-8-10-28(41)11-9-27)45-30(38-47-46-26(3)50(38)39)21-33(51)43-15-5-4-6-16-44-34(52)23-48-18-19-54-32-20-29(12-13-31(32)48)49(17-7-14-42)35(53)22-40/h8-13,20,30H,4-7,15-19,21-23H2,1-3H3,(H,43,51)(H,44,52)/t30-/m0/s1","IEXUFNUFUSSKQI-PMERELPUSA-N"
"3264","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","1100","85","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","850.83","849.25905652","3.58","58","6","13","2","18","176.3","C40H45Cl2N9O6S","InChI=1S/C40H45Cl2N9O6S/c1-25-26(2)58-40-37(25)38(28-5-7-29(42)8-6-28)46-31(39-48-47-27(3)51(39)40)22-34(52)44-12-16-55-19-20-56-17-13-45-35(53)24-49-15-18-57-33-21-30(9-10-32(33)49)50(14-4-11-43)36(54)23-41/h5-10,21,31H,4,12-20,22-24H2,1-3H3,(H,44,52)(H,45,53)/t31-/m0/s1","CPDVGNBJFIONLX-HKBQPEDESA-N"
"3265","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCOCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","3600","60","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","894.883","893.285271268","3.43","61","6","14","2","21","185.53","C42H49Cl2N9O7S","InChI=1S/C42H49Cl2N9O7S/c1-27-28(2)61-42-39(27)40(30-5-7-31(44)8-6-30)48-33(41-50-49-29(3)53(41)42)24-36(54)46-12-16-57-19-21-59-22-20-58-17-13-47-37(55)26-51-15-18-60-35-23-32(9-10-34(35)51)52(14-4-11-45)38(56)25-43/h5-10,23,33H,4,12-22,24-26H2,1-3H3,(H,46,54)(H,47,55)/t33-/m0/s1","QMBOIOPJFSHXPV-XIFFEERXSA-N"
"3266","O60885","BRD4","FEM1B","","","CC1=C(C)C2=C(S1)N1C(C)=NN=C1[C@H](CC(=O)NCCOCCOCCOCCOCCNC(=O)CN1CCOC3=CC(N(CCC#N)C(=O)CCl)=CC=C31)N=C2C1=CC=C(Cl)C=C1","1600","80","Degradation of BRD4 in HEK293T cells after 8 h treatment","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","938.936","937.311486016","3.28","64","6","15","2","24","194.76","C44H53Cl2N9O8S","InChI=1S/C44H53Cl2N9O8S/c1-29-30(2)64-44-41(29)42(32-5-7-33(46)8-6-32)50-35(43-52-51-31(3)55(43)44)26-38(56)48-12-16-59-19-21-61-23-24-62-22-20-60-17-13-49-39(57)28-53-15-18-63-37-25-34(9-10-36(37)53)54(14-4-11-47)40(58)27-45/h5-10,25,35H,4,12-24,26-28H2,1-3H3,(H,48,56)(H,49,57)/t35-/m0/s1","UUCUKSPUFPMKNK-DHUJRADRSA-N"
"3267","","BCR-ABL","FEM1B","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCCCCNC(=O)CN3CCOC4=CC(N(CCC#N)C(=O)CCl)=CC=C43)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","848.862","847.291025344","5.92","58","6","13","3","17","171.95","C40H47Cl2N11O4S","InChI=1S/C40H47Cl2N11O4S/c1-27-8-6-9-30(42)38(27)49-39(56)33-25-45-40(58-33)48-34-23-35(47-28(2)46-34)51-18-16-50(17-19-51)14-5-3-4-13-44-36(54)26-52-20-21-57-32-22-29(10-11-31(32)52)53(15-7-12-43)37(55)24-41/h6,8-11,22-23,25H,3-5,7,13-21,24,26H2,1-2H3,(H,44,54)(H,49,56)(H,45,46,47,48)","WIXPXNLUXBZCHT-UHFFFAOYSA-N"
"3268","","BCR-ABL","FEM1B","","","CC1=NC(NC2=NC=C(C(=O)NC3=C(C)C=CC=C3Cl)S2)=CC(N2CCN(CCOCCOCCOCCNC(=O)CN3CCOC4=CC(N(CCC#N)C(=O)CCl)=CC=C43)CC2)=N1","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1021/jacs.1c03980","938.94","937.322719396","4.41","64","6","16","3","23","199.64","C43H53Cl2N11O7S","InChI=1S/C43H53Cl2N11O7S/c1-30-5-3-6-33(45)41(30)52-42(59)36-28-48-43(64-36)51-37-26-38(50-31(2)49-37)54-14-12-53(13-15-54)16-19-61-22-24-62-23-21-60-18-10-47-39(57)29-55-17-20-63-35-25-32(7-8-34(35)55)56(11-4-9-46)40(58)27-44/h3,5-8,25-26,28H,4,10-24,27,29H2,1-2H3,(H,47,57)(H,52,59)(H,48,49,50,51)","YPMQMBLMNGXVCK-UHFFFAOYSA-N"
"3269","P03372","ER","CRBN","","ARV-471","O=C1CC[C@H](N2CC3=CC(N4CCN(CC5CCN(C6=CC=C([C@@H]7C8=CC=C(O)C=C8CC[C@@H]7C7=CC=CC=C7)C=C6)CC5)CC4)=CC=C3C2=O)C(=O)N1","2","","Degradation of ER in ER-positive breast cancer cell lines","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1158/1538-7445.SABCS18-P5-04-18","723.918","723.378455048","6.36","54","9","7","2","7","96.43","C45H49N5O4","InChI=1S/C45H49N5O4/c51-37-12-15-39-33(27-37)8-13-38(31-4-2-1-3-5-31)43(39)32-6-9-35(10-7-32)48-20-18-30(19-21-48)28-47-22-24-49(25-23-47)36-11-14-40-34(26-36)29-50(45(40)54)41-16-17-42(52)46-44(41)53/h1-7,9-12,14-15,26-27,30,38,41,43,51H,8,13,16-25,28-29H2,(H,46,52,53)/t38-,41+,43+/m1/s1","TZZDVPMABRWKIZ-XMOGEVODSA-N"
"3270","P10275","AR","CRBN","","ARV-110","N#CC1=CC=C(O[C@H]2CC[C@H](NC(=O)C3=CC=C(N4CCC(CN5CCN(C6=CC7=C(C=C6F)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)N=N3)CC2)C=C1Cl","1","","Degradation of AR in LNCaP cells","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","","10.1200/JCO.2019.37.7_suppl.259","812.303","811.300885996","3.94","58","8","12","2","9","181.17","C41H43ClFN9O6","InChI=1S/C41H43ClFN9O6/c42-31-19-28(4-1-25(31)22-44)58-27-5-2-26(3-6-27)45-38(54)33-7-9-36(48-47-33)51-13-11-24(12-14-51)23-49-15-17-50(18-16-49)35-21-30-29(20-32(35)43)40(56)52(41(30)57)34-8-10-37(53)46-39(34)55/h1,4,7,9,19-21,24,26-27,34H,2-3,5-6,8,10-18,23H2,(H,45,54)(H,46,53,55)/t26-,27-,34?","CLCTZVRHDOAUGJ-SYVGMNBRSA-N"