diff --git "a/data/PROTAC-Pedia.csv" "b/data/PROTAC-Pedia.csv"
new file mode 100644--- /dev/null
+++ "b/data/PROTAC-Pedia.csv"
@@ -0,0 +1,1206 @@
+PROTACDB ID,PROTAC SMILES,Active/Inactive,Best PROTAC,Cells,cLogP,Comments,Curator,Dc50,Dmax,E3 Binder SMILES,E3 Ligase,Ec50 of Ligand Cells,Ec50 of PROTAC Cells,exit_vector,Hbond acceptors,Hbond donors,Ic50 of Ligand,Ic50 of PROTAC,Ligand Name,Ligand SMILES,Linker,Linker Type,linker_ha,linker_no,linker_rb,MW,Off Targets Reported,PATENT,Ligand PDB,Ligand ID,Pubmed,PROTAC Name,Proteomics Data Available,Secondary Pubmed,Status,Target,Tested A Non Binding E3 Control,Tested Competition With Ligand,Tested Engagement In Cells,Tested Proteaseome Inhibitor,Time,TPSA
+1,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Inactive,No,MOLT-4,10.837319999999995,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CC=O,Alkane,6,3,2,1486.2819999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,1a,No,,Reviewed,Q07817,No,No,No,No,48,251.07
+2,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Inactive,No,MOLT-4,11.227419999999992,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCC=O,Alkane,7,3,3,1500.3089999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,1b,No,,Reviewed,Q07817,No,No,No,No,48,251.07
+3,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Inactive,No,MOLT-4,11.61751999999999,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCC=O,Alkane,8,3,4,1514.3359999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,1c,No,,Reviewed,Q07817,No,No,No,No,48,251.07
+4,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.007619999999987,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCC=O,Alkane,9,3,5,1528.3629999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,1d,No,,Reviewed,Q07817,No,No,No,No,48,251.07
+5,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.397719999999985,IC50's are for cell viability assays,Ronen Gabizon,53 nM,~ 100 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCCC=O,Alkane,10,3,6,1542.3899999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,1e (DT2216),No,,Reviewed,Q07817,No,No,Yes,No,48,251.07
+6,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.787819999999982,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCCCC=O,Alkane,11,3,7,1556.4169999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,1f,No,,Reviewed,Q07817,No,No,No,No,48,251.07
+7,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.090919999999986,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCCCC=O,Alkane,7,2,4,1500.3529999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,2a,No,,Reviewed,Q07817,No,No,No,No,48,233.99999999999997
+8,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.481019999999985,IC50's are for cell viability assays,Ronen Gabizon,93 nM,~ 90 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCCCCC=O,Alkane,8,2,5,1514.3799999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,2b,No,,Reviewed,Q07817,No,No,No,No,48,233.99999999999997
+9,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,12.871119999999982,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCCCCCC=O,Alkane,9,2,6,1528.4069999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,2c,No,,Reviewed,Q07817,No,No,No,No,48,233.99999999999997
+10,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,13.26121999999998,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCCCCCCC=O,Alkane,10,2,7,1542.4339999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,2d,No,,Reviewed,Q07817,No,No,No,No,48,233.99999999999997
+11,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,11.244019999999992,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,18,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCOCCC=O,PEG,10,4,6,1544.3619999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,3a,No,,Reviewed,Q07817,No,No,No,No,48,260.3
+12,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,10.480419999999997,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,19,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)COCCOCC=O,PEG,11,5,7,1560.3609999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,3b,No,,Reviewed,Q07817,No,No,No,No,48,269.53000000000003
+13,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCC(=O)N2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,10.870519999999994,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,19,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)COCCCOCC=O,PEG,12,5,8,1574.3879999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,3c,No,,Reviewed,Q07817,No,No,No,No,48,269.53000000000003
+14,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,10.937219999999995,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,18,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCOCC=O,PEG,7,3,4,1502.3249999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,4a,No,,Reviewed,Q07817,No,No,No,No,48,243.22999999999996
+15,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCN2CCN(CC[C@H](CSc3ccccc3)Nc3ccc(S(=O)(=O)NC(=O)c4ccc(N5CCN(CC6=C(c7ccc(Cl)cc7)CCC(C)(C)C6)CC5)cc4)cc3S(=O)(=O)C(F)(F)F)CC2)C(C)(C)C)cc1,Active,No,MOLT-4,10.953819999999993,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,19,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NCCOCCOCC=O,PEG,10,4,7,1546.3779999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,4b,No,,Reviewed,Q07817,No,No,No,No,48,252.46
+16,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCC(=O)N(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Inactive,No,MOLT-4,12.711919999999981,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCC=O,Alkane,6,1,3,1487.3099999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,5,No,,Reviewed,Q07817,No,No,No,No,48,247.82999999999998
+17,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,12.405119999999984,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCC=O,Alkane,4,1,1,1445.2729999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,6a,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+18,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,12.795219999999983,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCC=O,Alkane,5,1,2,1459.2999999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,6b,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+19,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,13.18531999999998,IC50's are for cell viability assays,Ronen Gabizon,71 nM,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCC=O,Alkane,6,1,3,1473.3269999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,6c,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+20,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,13.575419999999978,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCC=O,Alkane,7,1,4,1487.3539999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,6d,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+21,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,13.965519999999977,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCCC=O,Alkane,8,1,5,1501.3809999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,6e,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+22,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,14.355619999999975,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCCCC=O,Alkane,9,1,6,1515.4079999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,6f,No,,Reviewed,Q07817,No,No,No,No,48,230.76
+23,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,11.268019999999993,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,18,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,COCC=O,PEG,5,2,2,1491.2979999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,7a,No,,Reviewed,Q07817,No,No,No,No,48,249.22
+24,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,11.284619999999993,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,19,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,COCCOCC=O,PEG,8,3,5,1535.3509999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,7b,No,,Reviewed,Q07817,No,No,No,No,48,258.45
+25,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN(C)CC[C@H](CSc2ccccc2)Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CCC(C)(C)C5)CC4)cc3)cc2S(=O)(=O)C(F)(F)F)C(C)(C)C)cc1,Active,No,MOLT-4,11.301219999999994,IC50's are for cell viability assays,Ronen Gabizon,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,20,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,COCCOCCOCC=O,PEG,11,4,8,1579.4039999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,7c,No,,Reviewed,Q07817,No,No,No,No,48,267.68
+26,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)CCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.938700000000004,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCC(N)=O,Alkane,6,2,2,1314.9729999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,8a,No,,Reviewed,Q07817,No,No,No,No,48,235.01999999999995
+27,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)CCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,9.328800000000003,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCC(N)=O,Alkane,7,2,3,1328.9999999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,8b,No,,Reviewed,Q07817,No,No,No,No,48,235.01999999999995
+28,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)CCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,9.7189,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCC(N)=O,Alkane,8,2,4,1343.0269999999991,No degradation of BCL2,,4QNQ,1XJ,32145645,8c,No,,Reviewed,Q07817,No,No,No,No,48,235.01999999999995
+29,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)CCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Inactive,No,MOLT-4,10.108999999999998,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCCC(N)=O,Alkane,9,2,5,1357.0539999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,8d,No,,Reviewed,Q07817,No,No,No,No,48,235.01999999999995
+30,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)CCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Inactive,No,MOLT-4,10.499099999999997,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCCCC(N)=O,Alkane,10,2,6,1371.0809999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,8e,No,,Reviewed,Q07817,No,No,No,No,48,235.01999999999995
+31,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,9.022000000000004,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCN,Alkane,4,1,1,1286.9629999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,9a,No,,Reviewed,Q07817,No,No,No,No,48,217.94999999999996
+32,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,9.412100000000002,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCN,Alkane,5,1,2,1300.9899999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,9b,No,,Reviewed,Q07817,No,No,No,No,48,217.94999999999996
+33,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,9.8022,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCN,Alkane,6,1,3,1315.0169999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,9c,No,,Reviewed,Q07817,No,No,No,No,48,217.94999999999996
+34,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)COCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.19170000000001,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,18,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCC(N)=O,PEG,10,4,6,1375.0249999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,10a,No,,Reviewed,Q07817,No,No,No,No,48,253.47999999999996
+35,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)COCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.208300000000008,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,19,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOCC(N)=O,PEG,13,5,9,1419.0779999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,10b,No,,Reviewed,Q07817,No,No,No,No,48,262.71
+36,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)COCCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.22490000000001,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,20,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOCCOCC(N)=O,PEG,16,6,12,1463.1309999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,10c,No,,Reviewed,Q07817,No,No,No,No,48,271.93999999999994
+37,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=O)NCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.374700000000006,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,18,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCNC(N)=O,PEG,12,5,7,1404.0669999999996,No degradation of BCL2,,4QNQ,1XJ,32145645,11a,No,,Reviewed,Q07817,No,No,No,No,48,265.51
+38,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(C(=S)NCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Inactive,No,MOLT-4,8.539600000000005,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,18,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCNC(N)=S,PEG,12,4,7,1420.1349999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,11b,No,,Reviewed,Q07817,No,No,No,No,48,248.43999999999997
+39,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.648500000000006,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,17,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCN,PEG,6,2,3,1316.9889999999994,No degradation of BCL2,,4QNQ,1XJ,32145645,12a,No,,Reviewed,Q07817,No,No,No,No,48,227.17999999999998
+40,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.665100000000006,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,18,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCN,PEG,9,3,6,1361.0419999999992,No degradation of BCL2,,4QNQ,1XJ,32145645,12b,No,,Reviewed,Q07817,No,No,No,No,48,236.40999999999997
+41,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@@H](CCN5CCN(CCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,Active,No,MOLT-4,8.681700000000006,IC50's are for cell viability assays,Ronen Gabizon,4.5 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,19,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOCCN,PEG,12,4,9,1405.0949999999993,No degradation of BCL2,,4QNQ,1XJ,32145645,12c,No,,Reviewed,Q07817,No,No,No,No,48,245.64
+42,CN(CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F)C(=O)CCCn1cc(COCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1,Active,No,MOLT-4,9.077800000000003,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCc1cn(CC)nn1,Other,14,5,7,1429.0770000000005,No degradation of BCL2,,4QNQ,1XJ,32145645,13a,No,,Reviewed,Q07817,No,No,No,No,48,280.94999999999993
+43,CN(CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F)C(=O)CCCn1cc(COCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1,Active,No,MOLT-4,9.094400000000004,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,21,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOCc1cn(CC)nn1,Other,17,6,10,1473.1300000000006,No degradation of BCL2,,4QNQ,1XJ,32145645,13b,No,,Reviewed,Q07817,No,No,No,No,48,290.17999999999995
+44,CN(CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F)C(=O)CCCCCCn1cc(COCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1,Active,No,MOLT-4,10.248099999999999,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCn1cc(COCCOCC)nn1,Other,17,5,10,1471.1580000000004,No degradation of BCL2,,4QNQ,1XJ,32145645,14a,No,,Reviewed,Q07817,No,No,No,No,48,280.94999999999993
+45,CN(CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F)C(=O)CCCCCCn1cc(COCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1,Active,No,MOLT-4,10.2647,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,21,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCn1cc(COCCOCCOCC)nn1,Other,20,6,13,1515.2110000000005,No degradation of BCL2,,4QNQ,1XJ,32145645,14b,No,,Reviewed,Q07817,No,No,No,No,48,290.17999999999995
+46,CN(CCCCCCCn1cc(COCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,10.721499999999994,IC50's are for cell viability assays,Ronen Gabizon,6.3 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCn1cc(COCCOCC)nn1,Other,17,5,10,1457.1749999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,15a,No,,Reviewed,Q07817,No,No,No,No,48,263.87999999999994
+47,CN(CCCCCCCn1cc(COCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nn1)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,10.738099999999994,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,21,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCn1cc(COCCOCCOCC)nn1,Other,20,6,13,1501.228,No degradation of BCL2,,4QNQ,1XJ,32145645,15b,No,,Reviewed,Q07817,No,No,No,No,48,273.10999999999996
+48,CN(CCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,9.336200000000002,IC50's are for cell viability assays,Ronen Gabizon,10.6 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,C,Alkane,1,0,0,1231.8829999999998,No degradation of BCL2,,4QNQ,1XJ,32145645,16a,No,,Reviewed,Q07817,No,No,No,No,48,214.70999999999998
+49,CN(CCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,9.726299999999998,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CC,Alkane,2,0,0,1245.9099999999999,No degradation of BCL2,,4QNQ,1XJ,32145645,16b,No,,Reviewed,Q07817,No,No,No,No,48,214.70999999999998
+50,CN(CCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,10.116399999999997,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCC,Alkane,3,0,0,1259.937,No degradation of BCL2,,4QNQ,1XJ,32145645,16c,No,,Reviewed,Q07817,No,No,No,No,48,214.70999999999998
+51,CN(CCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,10.506499999999996,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCC,Alkane,4,0,1,1273.9639999999997,No degradation of BCL2,,4QNQ,1XJ,32145645,16d,No,,Reviewed,Q07817,No,No,No,No,48,214.70999999999998
+52,CN(CCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Inactive,No,MOLT-4,11.28669999999999,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCC,Alkane,6,0,3,1302.0179999999998,No degradation of BCL2,,4QNQ,1XJ,32145645,16e,No,,Reviewed,Q07817,No,No,No,No,48,214.70999999999998
+53,CN(CCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,8.979300000000004,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOC,PEG,4,1,1,1305.9619999999998,No degradation of BCL2,,4QNQ,1XJ,32145645,17a,No,,Reviewed,Q07817,No,No,No,No,48,233.17
+54,CN(CCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,Yes,MOLT-4,8.995900000000004,IC50's are for cell viability assays,Ronen Gabizon,2.5 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOC,PEG,7,2,4,1350.0149999999999,No degradation of BCL2,,4QNQ,1XJ,32145645,17b (XZ739),No,,Reviewed,Q07817,Yes,Yes,No,Yes,48,242.39999999999998
+55,CN(CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC[C@@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CCC(C)(C)C4)CC3)cc2)cc1S(=O)(=O)C(F)(F)F,Active,No,MOLT-4,9.012500000000005,IC50's are for cell viability assays,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOC,PEG,10,3,7,1394.0679999999995,No degradation of BCL2,,4QNQ,1XJ,32145645,17c,No,,Reviewed,Q07817,No,No,No,No,48,251.62999999999997
+56,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCCCC(=O)Nc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)cc4OC)nc32)c1,Inactive,No,H1975,6.555320000000007,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,4,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCC=O,Alkane,12,1,9,979.1079999999996,No,,5GMP,F62,32171162,14a,No,,Reviewed,P00533,No,No,No,No,16,234.33999999999997
+57,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCCCCNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc6ccccc6)CC5)cc4OC)nc32)c1,Inactive,No,H1975,7.093420000000008,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,aliphatic_CC,13,6,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCCN,Alkane,12,1,9,999.2709999999996,No,,5GMP,F62,32171162,14b,No,,Reviewed,P00533,No,No,No,No,16,226.14
+58,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCCCCNC(=O)c6ccc(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(c8ccc(Cl)cc8F)[C@H]7c7cccc(Cl)c7F)c(OC)c6)CC5)cc4OC)nc32)c1,Active,No,H1975,13.49949999999998,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,264 nM,,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,aliphatic_CC,14,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCCN,Alkane,12,1,9,1307.3849999999995,No,,5GMP,F62,32171162,14c,No,,Reviewed,P00533,No,No,No,No,16,224.93999999999994
+59,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCCCCCCCCCCNC(=O)c6ccc(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(c8ccc(Cl)cc8F)[C@H]7c7cccc(Cl)c7F)c(OC)c6)CC5)cc4OC)nc32)c1,Inactive,No,H1975,13.972899999999978,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,aliphatic_CC,14,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCCN,Alkane,12,1,9,1293.4019999999996,No,,5GMP,F62,32171162,14d,No,,Reviewed,P00533,No,No,No,No,16,207.86999999999995
+60,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,8.756440000000005,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,313 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCC=O,Alkane,12,1,9,1136.4339999999997,No,,5GMP,F62,32171162,14e,No,,Reviewed,P00533,No,No,No,No,16,233.32
+61,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,9.229840000000005,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,25.3 nM,~ 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCCC=O,Alkane,12,1,9,1122.4509999999998,"WT EGFR, 50 nM",,5GMP,F62,32171162,14f,No,,Reviewed,P00533,No,No,No,No,16,216.25
+62,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCCNC(=O)c6ccc(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(c8ccc(Cl)cc8F)[C@H]7c7cccc(Cl)c7F)c(OC)c6)CC5)cc4OC)nc32)c1,Active,No,H1975,12.719299999999983,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,77 nM,,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,aliphatic_CC,14,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCCN,Alkane,10,1,7,1279.3309999999997,No,,5GMP,F62,32171162,14g,No,,Reviewed,P00533,No,No,No,No,16,224.93999999999994
+63,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCNC(=O)c6ccc(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(c8ccc(Cl)cc8F)[C@H]7c7cccc(Cl)c7F)c(OC)c6)CC5)cc4OC)nc32)c1,Inactive,No,H1975,11.939099999999986,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,aliphatic_CC,14,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCN,Alkane,8,1,5,1251.2769999999998,No,,5GMP,F62,32171162,14h,No,,Reviewed,P00533,No,No,No,No,16,224.93999999999994
+64,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCNC(=O)c6ccc(NC(=O)[C@@H]7N[C@@H](CC(C)(C)C)[C@](C#N)(c8ccc(Cl)cc8F)[C@H]7c7cccc(Cl)c7F)c(OC)c6)CC5)cc4OC)nc32)c1,Inactive,No,H1975,11.15889999999999,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,aliphatic_CC,14,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCN,Alkane,6,1,3,1223.2229999999997,No,,5GMP,F62,32171162,14i,No,,Reviewed,P00533,No,No,No,No,16,224.93999999999994
+65,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,7.976240000000009,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,69 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCC=O,Alkane,10,1,7,1108.3799999999997,No,,5GMP,F62,32171162,14j,No,,Reviewed,P00533,No,No,No,No,16,233.32
+66,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,7.196040000000007,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,235 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCC=O,Alkane,8,1,5,1080.3259999999996,No,,5GMP,F62,32171162,14k,No,,Reviewed,P00533,No,No,No,No,16,233.32
+67,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Inactive,No,H1975,6.415840000000006,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCC=O,Alkane,6,1,3,1052.2719999999997,No,,5GMP,F62,32171162,14l,No,,Reviewed,P00533,No,No,No,No,16,233.32
+68,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,8.449640000000008,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,132 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCCCC=O,Alkane,10,1,7,1094.3969999999997,No,,5GMP,F62,32171162,14m,No,,Reviewed,P00533,No,No,No,No,16,216.25
+69,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,No,H1975,7.669440000000009,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,466 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCCCC=O,Alkane,8,1,5,1066.3429999999996,No,,5GMP,F62,32171162,14n,No,,Reviewed,P00533,No,No,No,No,16,216.25
+70,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Active,Yes,H1975,6.889240000000007,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity). EC50 of PROTAC was measured in H1975 cell line",Ronen Gabizon,5.9 nM,100 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCCCC=O,Alkane,6,1,3,1038.2889999999998,No,,5GMP,F62,32171162,14o,No,,Reviewed,P00533,No,Yes,No,Yes,16,216.25
+71,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(CCCC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4OC)nc32)c1,Inactive,No,H1975,6.109040000000007,"Ligand IC50 is 0.26 nM (Kd), 4.0 nM (kinase activity)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,< 4 nM,,XTF-262,C=CC(=O)Nc1cccc(-n2c(=O)cc(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1,CCC=O,Alkane,4,1,1,1010.2349999999996,No,,5GMP,F62,32171162,14p,No,,Reviewed,P00533,No,No,No,No,16,216.25
+72,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O,Inactive,No,PBMCs,3.032120000000006,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,14,5,2.1 nM,0.29 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCOCCOCCOCCC=O,PEG,14,4,10,942.1049999999999,No,,5UIU,8CG,31312412,2,No,,Reviewed,Q9NWZ3,No,No,No,No,24,242.85999999999999
+73,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O,Active,No,PBMCs,6.493220000000005,,Ronen Gabizon,3 uM,50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,11,5,2.1 nM,0.099 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCCCCCCCCCCC=O,Alkane,14,1,10,936.1890000000001,No,,5UIU,8CG,31312412,3,No,,Reviewed,Q9NWZ3,Yes,No,No,No,24,215.17
+74,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCOCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2cc1C(N)=O,Inactive,No,PBMCs,0.8812000000000029,,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,13,3,2.1 nM,,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCOCCOCCOCCO,PEG,13,4,9,757.7530000000002,No,,5UIU,8CG,31312412,4,No,,Reviewed,Q9NWZ3,No,No,No,No,24,224.01000000000002
+75,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCCCCCCCCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2cc1C(N)=O,Inactive,No,PBMCs,4.3423000000000025,,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,10,3,2.1 nM,2.5 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCCCCCCCCCCO,Alkane,13,1,9,751.8370000000002,No,,5UIU,8CG,31312412,5,No,,Reviewed,Q9NWZ3,No,No,No,No,24,196.32
+76,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCC#Cc2cnc(OC[C@@H]3CCC(=O)N3)c3cc(OC)c(C(N)=O)cc23)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Inactive,No,PBMCs,2.7436000000000096,,Ronen Gabizon,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aryl_C,13,6,2.1 nM,0.022 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCOCCOCCOCCC=O,PEG,14,4,10,995.1879999999995,No,,5UIU,8CG,31312412,6,No,,Reviewed,Q9NWZ3,No,No,No,No,24,250.86999999999998
+77,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCCC#Cc2cnc(OC[C@@H]3CCC(=O)N3)c3cc(OC)c(C(N)=O)cc23)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Inactive,No,PBMCs,6.204700000000008,,Ronen Gabizon,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aryl_C,10,6,2.1 nM,21 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCCCCCCCCCCC=O,Alkane,14,1,10,989.2719999999996,No,,5UIU,8CG,31312412,7,No,,Reviewed,Q9NWZ3,No,No,No,No,24,223.17999999999998
+78,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O,Inactive,No,THP-1,3.3724200000000026,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,11,5,2.1 nM,0.099 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCCC=O,Alkane,6,1,2,823.973,No,,5UIU,8CG,31312412,3B,No,,Reviewed,Q9NWZ3,Yes,No,No,No,24,215.17
+79,COc1cc2c(OC[C@@H]3CCC(=O)N3)ncc(C#CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c2cc1C(N)=O,Inactive,No,THP-1,3.7625200000000047,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,11,5,2.1 nM,0.099 nM,PF-06650833 without fluorine and ethyl groupo,COc1cc2c(OC[C@@H]3CCC(=O)N3)nccc2cc1C(N)=O,C#CCCCC=O,Alkane,7,1,3,837.9999999999999,No,,5UIU,8CG,31312412,3C,No,,Reviewed,Q9NWZ3,Yes,No,No,No,24,215.17
+80,CC[C@H]1[C@@H](COc2ncc(C#CCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F,Active,No,PBMCs,7.077320000000007,,Ronen Gabizon,259 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,11,5,2.1 nM,,PF-06650833,CC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F,C#CCCCCCCCCCCC=O,Alkane,14,1,10,982.2329999999997,No,,5UIU,8CG,31312412,8,No,,Reviewed,Q9NWZ3,No,No,No,No,24,215.17
+81,CC[C@H]1[C@@H](COc2ncc(C#CCN3CCC4(CC3)CCN(c3ncc(C(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)cn3)CC4)c3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F,Active,Yes,PBMCs,4.962520000000007,,Ronen Gabizon,151 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,15,5,2.1 nM,,PF-06650833,CC[C@H]1[C@@H](COc2nccc3cc(C(N)=O)c(OC)cc23)NC(=O)[C@H]1F,C#CCN1CCC2(CC1)CCN(c1ncc(C=O)cn1)CC2,Other,22,5,3,1086.3049999999996,No,,5UIU,8CG,31312412,9,No,,Reviewed,Q9NWZ3,Yes,No,No,Yes,24,247.42999999999998
+82,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,8.732860000000006,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,17,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCCOCCCCCC=O,non-PEG polyether,18,4,15,1158.933999999999,No,,2GQG,1N1,31539241,7,No,,Reviewed,P00519,No,No,No,No,24,225.59999999999997
+83,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,8.259460000000006,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,17,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCCOCCCCCC=O,non-PEG polyether,18,4,15,1172.916999999999,No,,2GQG,1N1,31539241,9,No,,Reviewed,P00519,No,No,No,No,24,242.66999999999996
+84,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.9520600000000075,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,19,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,COCCOCCOCCOCCOCCC=O,PEG,18,6,15,1176.8609999999992,No,,2GQG,1N1,31539241,10,No,,Reviewed,P00519,No,No,No,No,24,261.12999999999994
+85,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.935460000000007,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,18,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,COCCOCCOCCOCCC=O,PEG,15,5,12,1132.8079999999993,No,,2GQG,1N1,31539241,11,No,,Reviewed,P00519,No,No,No,No,24,251.89999999999998
+86,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.918860000000006,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,17,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,COCCOCCOCCC=O,PEG,12,4,9,1088.7549999999997,No,,2GQG,1N1,31539241,12,No,,Reviewed,P00519,No,No,No,No,24,242.66999999999996
+87,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCOCCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.9022600000000045,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,16,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,COCCOCCC=O,PEG,9,3,6,1044.7019999999998,No,,2GQG,1N1,31539241,13,No,,Reviewed,P00519,No,No,No,No,24,233.43999999999994
+88,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)COCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.122060000000004,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOCC=O,PEG,6,2,3,1016.6479999999996,No,,2GQG,1N1,31539241,14,No,,Reviewed,P00519,No,No,No,No,24,233.43999999999994
+89,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,10.550259999999994,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCCCCCCCCCCC=O,Alkane,15,1,12,1124.9199999999992,No,,2GQG,1N1,31539241,15,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+90,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,9.770059999999999,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCCCCCCCCC=O,Alkane,13,1,10,1096.8659999999993,No,,2GQG,1N1,31539241,16,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+91,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,8.209660000000008,,Ronen Gabizon,10.1 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCCCCC=O,Alkane,9,1,6,1040.7579999999998,No,,2GQG,1N1,31539241,17,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+92,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,7.819560000000009,,Ronen Gabizon,37.9 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCCCC=O,Alkane,8,1,5,1026.7309999999998,No,,2GQG,1N1,31539241,18,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+93,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,Yes,K562,7.429460000000008,,Ronen Gabizon,8.5 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCCC=O,Alkane,7,1,4,1012.7039999999997,"EPHB4, RIPK2, Src, PDGFRβ, BTK",,2GQG,1N1,31539241,19 (SIAIS178),No,,Reviewed,P00519,Yes,Yes,Yes,Yes,24,214.97999999999996
+94,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,7.0393600000000065,,Ronen Gabizon,17.9 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCC=O,Alkane,6,1,3,998.6769999999997,No,,2GQG,1N1,31539241,20,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+95,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,6.649260000000006,,Ronen Gabizon,34.7 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCC=O,Alkane,5,1,2,984.6499999999996,No,,2GQG,1N1,31539241,21,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+96,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,6.259160000000006,,Ronen Gabizon,40.2 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCC=O,Alkane,4,1,1,970.6229999999997,No,,2GQG,1N1,31539241,22,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+97,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562,5.869060000000005,,Ronen Gabizon,611 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,14,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CC=O,Alkane,3,1,0,956.5959999999997,No,,2GQG,1N1,31539241,23,No,,Reviewed,P00519,No,No,No,No,24,214.97999999999996
+98,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCc3cn(CCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)nn3)CC2)n1,Inactive,No,K562,6.483460000000005,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,17,5,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCc1cn(CCCC=O)nn1,Other,12,4,5,1079.7549999999997,No,,2GQG,1N1,31539241,24,No,,Reviewed,P00519,No,No,No,No,24,245.68999999999994
+99,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CNC(=O)CCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,5.375360000000004,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,15,6,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,NC(=O)CCCC=O,Alkane,8,3,4,1027.6749999999995,No,,2GQG,1N1,31539241,25,No,,Reviewed,P00519,No,No,No,No,24,244.07999999999993
+100,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(C(=O)CCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,8.496160000000007,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,15,6,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCNC(=O)CCCCCCCCC=O,Alkane,16,3,11,1139.8909999999992,No,,2GQG,1N1,31539241,26,No,,Reviewed,P00519,No,No,No,No,24,244.07999999999993
+101,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCNC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Inactive,No,K562,8.969560000000005,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,15,6,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCNC(=O)CCCCCCCCC=O,Other,16,3,11,1125.9079999999992,No,,2GQG,1N1,31539241,27,No,,Reviewed,P00519,No,No,No,No,24,227.00999999999993
+102,COc1cc(/C=C2\SC(=O)N(Cc3cn(CCCNC(=O)[C@@H](N)CCCNC(=N)N)nn3)C2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,Active,No,MCF-7,3.302850000000002,,Ronen Gabizon,5 uM,> 90 %,N=C(N)NCCC[C@H](N)C(=O)O,Ubr1,,,other,12,5,,,29,COc1cc(/C=C2\SC(=O)NC2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,Cc1cn(CCCN)nn1,Other,10,4,3,714.7310000000002,No,,3K6P,5FB,31511327,Arg-TERRalpha,No,,Reviewed,P11474,No,Yes,No,Yes,48,227.35999999999996
+103,COc1cc(/C=C2\SC(=O)N(Cc3cn(CCCNC(=O)[C@@H](N)Cc4c[nH]cn4)nn3)C2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,Active,Yes,MCF-7,4.0053800000000015,,Ronen Gabizon,0.5 uM,~ 90 %,N[C@@H](Cc1c[nH]cn1)C(=O)O,Ubr1,,,other,12,3,,,29,COc1cc(/C=C2\SC(=O)NC2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,Cc1cn(CCCN)nn1,Other,10,4,3,695.6840000000002,No,,3K6P,5FB,31511327,His-TERRalpha,No,,Reviewed,P11474,No,Yes,No,Yes,48,194.14
+104,CC[C@H](C)[C@H](N)c1cn([C@@H](Cc2ccc(O)cc2)C(=O)N2CCN(c3nc(NCCOCCOCCOCc4cn(CCOCCOCCOCCOCCOCCNC(=O)CN5CCN(C(=O)N6C(c7ccc(OC)cc7OC(C)C)=N[C@@H](c7ccc(Cl)cc7)[C@H]6c6ccc(Cl)cc6)CC5=O)nn4)nc(N4CCN(C(=O)[C@H](Cc5ccc(O)cc5)n5cc([C@@H](N)[C@@H](C)CC)nn5)CC4)n3)CC2)nn1,Active,No,Hs578t,7.887200000000026,,Ronen Gabizon,> 10 uM,,COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,amine_to_methylamine,35,6,112 nM,,IY-IY,CC[C@H](C)[C@H](N)c1cn([C@@H](Cc2ccc(O)cc2)C(=O)N2CCN(c3nc(N)nc(N4CCN(C(=O)[C@H](Cc5ccc(O)cc5)n5cc([C@@H](N)[C@@H](C)CC)nn5)CC4)n3)CC2)nn1,CCOCCOCCOCc1cn(CCOCCOCCOCCOCCOCCNC(C)=O)nn1,Other,36,13,27,1963.1529999999996,No,,,,31512882,11,No,,Reviewed,Q16288,No,No,No,No,24,460.04999999999984
+105,CC[C@H](C)[C@H](N)c1cn([C@@H](Cc2ccc(O)cc2)C(=O)N2CCN(c3nc(NCCOCCOCCOCc4cn(CCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)nc(N4CCN(C(=O)[C@H](Cc5ccc(O)cc5)n5cc([C@@H](N)[C@@H](C)CC)nn5)CC4)n3)CC2)nn1,Active,Yes,Hs578t,3.6765000000000114,DC50 is between 0.1uM-1uM,Ronen Gabizon,< 1 uM,100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,29,7,112 nM,,IY-IY,CC[C@H](C)[C@H](N)c1cn([C@@H](Cc2ccc(O)cc2)C(=O)N2CCN(c3nc(N)nc(N4CCN(C(=O)[C@H](Cc5ccc(O)cc5)n5cc([C@@H](N)[C@@H](C)CC)nn5)CC4)n3)CC2)nn1,CCOCCOCCOCc1cn(CCCCCC=O)nn1,Other,22,7,15,1447.675,No,,,,31512882,4,No,,Reviewed,Q16288,No,No,No,No,24,422.7699999999999
+106,CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,Active,No,"RS4;11, MOLM-13",4.335340000000002,"Direct degration studies in this paper only conducted for first and final compounds; during the med chem campaign cell viability was used as the read out. Complex structure with the ligand was modeled based on 4Z93. IC50 of the ligand is between 2nM and 7nM, depending on which BRD. DC50 is between 3nM-10nM.",Ronen Gabizon,< 10 nM,100 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,15,5,< 7 nM,,HJB97,CCn1nc(C2CC2)cc1Nc1ncnc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,O=CNCCCCNC(=O)CO,Alkane,12,5,7,871.9119999999998,No,,,,28339196,9,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,3,257.66
+107,CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCCCCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,Active,No,"RS4;11, MOLM-13",6.522840000000007,"Complex structure with the ligand was modeled based on 4Z93. IC50 of the ligand is between 2nM and 7nM, depending on which BRD",Ronen Gabizon,< 1 nM,100 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,12,4,< 7 nM,,HJB97,CCn1nc(C2CC2)cc1Nc1ncnc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,CCCCCCNC=O,Alkane,9,2,6,812.932,No,,,,28339196,21,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,3,202.25999999999996
+108,CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCCCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,Active,Yes,"RS4;11, MOLM-13",6.132740000000006,"Complex structure with the ligand was modeled based on 4Z93. IC50 of the ligand is between 2nM and 7nM, depending on which BRD",Ronen Gabizon,< 1 nM,100 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,12,4,< 7 nM,,HJB97,CCn1nc(C2CC2)cc1Nc1ncnc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,CCCCCNC=O,Alkane,8,2,5,798.905,No,,,,28339196,23 (BET-d260),No,,Reviewed,"O60885, P25440, Q15059",Yes,Yes,No,Yes,3,202.25999999999996
+109,CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,Active,No,"RS4;11, MOLM-13",5.742640000000005,"Complex structure with the ligand was modeled based on 4Z93. IC50 of the ligand is between 2nM and 7nM, depending on which BRD",Ronen Gabizon,~ 3 nM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,12,4,< 7 nM,,HJB97,CCn1nc(C2CC2)cc1Nc1ncnc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,CCCCNC=O,Alkane,7,2,4,784.8779999999999,No,,,,28339196,24,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,3,202.25999999999996
+110,CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,Active,No,"RS4;11, MOLM-13",5.352540000000005,"Complex structure with the ligand was modeled based on 4Z93. IC50 of the ligand is between 2nM and 7nM, depending on which BRD",Ronen Gabizon,~ 10 nM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,12,4,< 7 nM,,HJB97,CCn1nc(C2CC2)cc1Nc1ncnc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12,CCCNC=O,Alkane,6,2,3,770.8509999999999,No,,,,28339196,25,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,3,202.25999999999996
+111,CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3OC)nc2N1C1CCCC1,Active,Yes,"MV4-11, MOLM-13, KG1",3.009100000000002,They show "dual" degradation but don't do any test that the dual degradation actually made any difference. They make it sound novel but of course we can call our PROTACs "dual" degraders if you can the off-targets "targets". EC50 of ligand is in measured in MV4-11 cell line. EC50 of PROTAC is between 4.5nM-6.94nM (depended on the cell line).,Ronen Gabizon,< 5 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,14,4,25 nM,,BI2536,CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccccc3OC)nc2N1C1CCCC1,CCOCCOCCNC=O,PEG,11,4,8,811.8969999999998,No,,4O74,R78,31708096,HBL-4,No,,Reviewed,"O60885, P53350",No,No,No,No,24,213.73000000000002
+112,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCn2cc(Nc3ncc(Cl)c(NCc4cc(F)ccc4F)n3)cn2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,No,THP,8.033700000000007,Structutre with ligand is modeled in the paper.,Ronen Gabizon,2.5 uM,60 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aliphatic_CC,11,6,< 1 nM,~ 100 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,CCCCCCCCC=O,Alkane,10,1,7,972.6269999999996,No,,,,32001089,7 (JP-2),No,,Reviewed,"O60674, P23458",No,No,No,No,24,187.29999999999998
+113,Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CCCCCCCCCn2cc(Nc3ncc(Cl)c(NCc4cc(F)ccc4F)n3)cn2)C(C)(C)C)cc1,Inactive,No,THP,8.322220000000005,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,12,5,< 1 nM,~ 100 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,CCCCCCCCC=O,Alkane,10,1,7,919.544,No,,,,32001089,24,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,179.29000000000002
+114,O=C1CCC(N2Cc3c(NC(=O)CCCCCCCCCn4cc(Nc5ncc(Cl)c(NCc6cc(F)ccc6F)n5)cn4)cccc3C2=O)C(=O)N1,Inactive,No,THP,6.480900000000006,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,4,< 1 nM,< 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,CCCCCCCCC=O,Alkane,10,1,7,748.2350000000001,No,,,,32001089,25,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,163.24
+115,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCn2cc(Nc3ncc(Cl)c(NCc4cc(F)ccc4F)n3)cn2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,No,THP,4.979300000000013,Structutre with ligand is modeled in the paper.,Ronen Gabizon,> 5 uM,30 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aliphatic_CC,15,6,< 1 nM,~ 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,COCCOCCOCCOCC=O,PEG,14,5,11,1036.6229999999998,No,,,,32001089,6 (JP-1),No,,Reviewed,"O60674, P23458",No,No,No,No,24,224.22
+116,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCn2cc(Nc3ncc(Cl)c(NCc4cc(F)ccc4F)n3)cn2)C(C)(C)C)cc1,Inactive,No,THP,5.267820000000005,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,5,< 1 nM,10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,COCCOCCOCCOCC=O,PEG,14,5,11,983.5399999999997,No,,,,32001089,26,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,216.20999999999998
+117,O=C1CCC(N2Cc3c(NC(=O)COCCOCCOCCOCCn4cc(Nc5ncc(Cl)c(NCc6cc(F)ccc6F)n5)cn4)cccc3C2=O)C(=O)N1,Inactive,No,THP,3.4265000000000017,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,4,< 1 nM,10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,COCCOCCOCCOCC=O,PEG,14,5,11,812.2310000000001,No,,,,32001089,27,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,200.16
+118,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,No,THP,7.9495000000000084,Structutre with ligand is modeled in the paper.,Ronen Gabizon,> 5 uM,50 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aryl_O,12,6,< 1 nM,~ 100 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCCCCCCCCCO,Alkane,12,2,9,1002.6529999999995,No,,,,32001089,13 (JP-4),No,,Reviewed,"O60674, P23458",No,No,No,No,24,196.53
+119,Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)CCCCCCCCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C(C)(C)C)cc1,Inactive,No,THP,8.238020000000006,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,5,< 1 nM,10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCCCCCCCCCO,Alkane,12,2,9,949.5699999999998,No,,,,32001089,28,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,188.51999999999998
+120,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)cc(OCCCCCCCCCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3F)n2)cn1,Inactive,No,THP,6.396700000000006,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,11,4,< 1 nM,< 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCCCCCCCCCO,Alkane,12,2,9,778.2610000000001,No,,,,32001089,29,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,172.46999999999997
+121,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,No,THP,4.895100000000013,Structutre with ligand is modeled in the paper.,Ronen Gabizon,~ 5 uM,60 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aryl_O,16,6,< 1 nM,~ 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCO,PEG,16,6,13,1066.6489999999997,No,,,,32001089,10 (JP-3),No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,233.45000000000002
+122,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C(C)(C)C)cc1,Inactive,No,THP,5.183620000000005,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,17,5,< 1 nM,~ 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCO,PEG,16,6,13,1013.5659999999997,No,,,,32001089,30,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,225.44
+123,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)cc(OCCOCCOCCOCCOCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3F)n2)cn1,Inactive,No,THP,3.3423000000000007,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,15,4,< 1 nM,~ 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCO,PEG,16,6,13,842.2570000000001,No,,,,32001089,31,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,209.39
+124,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Inactive,No,THP,4.928300000000015,Structutre with ligand is modeled in the paper. IC50 of PROTAC is between 10nM-50nM.,Ronen Gabizon,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,aryl_O,18,6,< 1 nM,< 50 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCOCCOCCO,PEG,22,8,19,1154.755,No,,,,32001089,32,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,251.91
+125,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOc2cc(F)cc(CNc3nc(Nc4cnn(C)c4)ncc3Cl)c2F)C(C)(C)C)cc1,Inactive,No,THP,5.216820000000007,Structutre with ligand is modeled in the paper. IC50 of PROTAC is between 10nM-50nM.,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,19,5,< 1 nM,< 50 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCOCCOCCO,PEG,22,8,19,1101.6719999999991,No,,,,32001089,33,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,243.89999999999998
+126,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)cc(OCCOCCOCCOCCOCCOCCOCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3F)n2)cn1,Inactive,No,THP,3.3755000000000006,Structutre with ligand is modeled in the paper.,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,4,< 1 nM,~ 10 nM,Pyrimidine 1,Cn1cc(Nc2ncc(Cl)c(NCc3cc(F)ccc3F)n2)cn1,O=CCOCCOCCOCCOCCOCCOCCO,PEG,22,8,19,930.3629999999998,No,,,,32001089,34,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,227.85000000000002
+127,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCCCCCCCCN2CCN(CCCOc3ccc(-c4cnc5cccc(-c6cc(F)c(CN7CCS(=O)(=O)CC7)c(F)c6)c5n4)cc3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,Yes,THP,8.940800000000008,DC50 is between 1uM-2uM. Dmax is for JAK1.,Ronen Gabizon,< 2 uM,50 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,morpholine_to_piperazine,14,4,10 nM,> 100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCCCCCCCCC=O,Alkane,12,2,9,1273.6470000000002,No,,3KRR,DQX,32001089,17 (JP-6),No,,Reviewed,"O60674, P23458, P52333",Yes,Yes,No,Yes,24,207.73999999999995
+128,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCCCCCCCCC(=O)N[C@@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,THP,9.229320000000003,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,15,3,< 1 nM,100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCCCCCCCCC=O,Alkane,12,2,9,1220.5639999999985,No,,3KRR,DQX,32001089,35,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,199.72999999999996
+129,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCCCCCCCCC(=O)Nc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)CC1,Inactive,No,THP,7.388000000000007,IC50 of PROTAC is 10-100 nM,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,13,2,< 1 nM,< 100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCCCCCCCCC=O,Alkane,12,2,9,1049.254999999999,No,,3KRR,DQX,32001089,36,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,183.67999999999998
+130,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(CCCOc3ccc(-c4cnc5cccc(-c6cc(F)c(CN7CCS(=O)(=O)CC7)c(F)c6)c5n4)cc3OC)CC2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,No,THP,5.886400000000019,Dmax is for JAK1,Ronen Gabizon,~ 2.5 uM,60 %,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,morpholine_to_piperazine,18,4,< 1 nM,100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1337.6430000000005,No,,3KRR,DQX,32001089,15 (JP-5),No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,244.65999999999997
+131,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCOCCOCCOCCOCC(=O)N[C@@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,THP,6.174920000000011,IC50 of PROTAC is 10-100 nM,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,19,3,< 1 nM,< 100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1284.5599999999986,No,,3KRR,DQX,32001089,37,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,236.64999999999998
+132,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCOCCOCCOCCOCC(=O)Nc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)CC1,Inactive,No,THP,4.333600000000004,,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,17,2,< 1 nM,10 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1113.250999999999,No,,3KRR,DQX,32001089,38,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,220.6
+133,CN[C@H](C)C(=O)N[C@@H](C(=O)N1C[C@H](NC(=O)COCCOCCOCCOCCOCCOCCN2CCN(CCCOc3ccc(-c4cnc5cccc(-c6cc(F)c(CN7CCS(=O)(=O)CC7)c(F)c6)c5n4)cc3OC)CC2)C[C@@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Inactive,No,THP,5.919600000000017,,Ronen Gabizon,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,morpholine_to_piperazine,20,4,< 1 nM,100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCCOCCOCC=O,PEG,22,8,19,1425.7490000000003,No,,3KRR,DQX,32001089,39,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,263.11999999999995
+134,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)N[C@@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,THP,6.208120000000013,,Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,morpholine_to_piperazine,21,3,< 1 nM,100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCCOCCOCC=O,PEG,22,8,19,1372.6659999999986,No,,3KRR,DQX,32001089,40,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,255.10999999999996
+135,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCN(CCOCCOCCOCCOCCOCCOCC(=O)Nc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)CC1,Inactive,No,THP,4.366800000000008,IC50 of PROTAC is 10-100 nM,Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,19,2,< 1 nM,< 100 nM,Quinoxaline,COc1cc(-c2cnc3cccc(-c4cc(F)c(CN5CCS(=O)(=O)CC5)c(F)c4)c3n2)ccc1OCCCN1CCOCC1,NCCOCCOCCOCCOCCOCCOCC=O,PEG,22,8,19,1201.3569999999993,No,,3KRR,DQX,32001089,41,No,,Reviewed,"O60674, P23458, P52333",No,No,No,No,24,239.05999999999997
+136,O=C1CCC(N2Cc3c(NC(=O)CCCCCCCN4CCN(c5ccc(Nc6cc7c(N8CCC(CO)CC8)nc(Nc8ccc(F)cc8)nc7cn6)nc5)CC4)cccc3C2=O)C(=O)N1,Active,Yes,HCC827,6.117100000000006,IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant),Ronen Gabizon,45.2 nM,87 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCCCCC=O,Alkane,10,2,7,913.0719999999998,No,,,,31951960,2,No,,Reviewed,P00533,No,Yes,No,Yes,48,201.14999999999995
+137,O=C1CCC(N2Cc3c(NC(=O)CCCCCCN4CCN(c5ccc(Nc6cc7c(N8CCC(CO)CC8)nc(Nc8ccc(F)cc8)nc7cn6)nc5)CC4)cccc3C2=O)C(=O)N1,Active,No,HCC827,5.727000000000005,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCCCC=O,Alkane,9,2,6,899.0449999999997,No,,,,31951960,3,No,,Reviewed,P00533,No,No,No,No,48,201.14999999999995
+138,O=C1CCC(N2Cc3c(NC(=O)CCCCCN4CCN(c5ccc(Nc6cc7c(N8CCC(CO)CC8)nc(Nc8ccc(F)cc8)nc7cn6)nc5)CC4)cccc3C2=O)C(=O)N1,Active,No,HCC827,5.336900000000004,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCCC=O,Alkane,8,2,5,885.0179999999998,No,,,,31951960,4,No,,Reviewed,P00533,No,No,No,No,48,201.14999999999995
+139,O=C1CCC(N2Cc3c(NC(=O)CCCCN4CCN(c5ccc(Nc6cc7c(N8CCC(CO)CC8)nc(Nc8ccc(F)cc8)nc7cn6)nc5)CC4)cccc3C2=O)C(=O)N1,Active,No,HCC827,4.946800000000004,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCC=O,Alkane,7,2,4,870.9909999999999,No,,,,31951960,5,No,,Reviewed,P00533,No,No,No,No,48,201.14999999999995
+140,O=C1CCC(N2Cc3c(NC(=O)CCCCCCCn4cc(CN5CCN(c6ccc(Nc7cc8c(N9CCC(CO)CC9)nc(Nc9ccc(F)cc9)nc8cn7)nc6)CC5)nn4)cccc3C2=O)C(=O)N1,Active,No,HCC827,5.908800000000006,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCc1cn(CCCCCCCC=O)nn1,Other,16,5,9,994.1499999999995,No,,,,31951960,6,No,,Reviewed,P00533,No,No,No,No,48,231.85999999999993
+141,O=C(CN1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1)NCCC(=O)Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Active,No,HCC827,3.2828000000000017,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCC(=O)NCCC=O,Alkane,9,4,4,899.9889999999995,No,,,,31951960,7,No,,Reviewed,P00533,No,No,No,No,48,230.25
+142,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCN(CCCCCCCC(=O)Nc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,Active,No,HCC827,6.438800000000006,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,4,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCCCCC=O,Alkane,10,2,7,926.1149999999997,No,,,,31951960,8,No,,Reviewed,P00533,No,No,No,No,48,184.15999999999997
+143,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCN(CC(=O)NCCC(=O)Nc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,Active,No,HCC827,3.6045000000000043,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,5,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCC(=O)NCCC=O,Alkane,9,4,4,913.0319999999996,No,,,,31951960,9,No,,Reviewed,P00533,No,No,No,No,48,213.26
+144,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(c3ccc(Nc4cc5c(N6CCC(CO)CC6)nc(Nc6ccc(F)cc6)nc5cn4)nc3)CC2)C(C)(C)C)cc1,Active,Yes,HCC827,7.568320000000007,Structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant),Ronen Gabizon,34.8 nM,98 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCCCC=O,Alkane,9,2,6,1070.3539999999991,No,,,,31951960,10,No,,Reviewed,P00533,No,No,No,No,48,217.2
+145,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCN2CCN(c3ccc(Nc4cc5c(N6CCC(CO)CC6)nc(Nc6ccc(F)cc6)nc5cn4)nc3)CC2)C(C)(C)C)cc1,Active,No,HCC827,6.788120000000005,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,NCCCCC=O,Alkane,7,2,4,1042.2999999999995,No,,,,31951960,11,No,,Reviewed,P00533,No,No,No,No,48,217.2
+146,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCOCCOCCOCCN2CCN(c3ccc(Nc4cc5c(N6CCC(CO)CC6)nc(Nc6ccc(F)cc6)nc5cn4)nc3)CC2)C(C)(C)C)cc1,Active,No,HCC827,6.141020000000009,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,19,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,CCOCCOCCOCCN,PEG,12,4,9,1118.394999999999,No,,,,31951960,12,No,,Reviewed,P00533,No,No,No,No,48,227.82
+147,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCOCCOCCN2CCN(c3ccc(Nc4cc5c(N6CCC(CO)CC6)nc(Nc6ccc(F)cc6)nc5cn4)nc3)CC2)C(C)(C)C)cc1,Active,No,HCC827,6.124420000000006,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,18,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,CCOCCOCCN,PEG,9,3,6,1074.3419999999992,No,,,,31951960,13,No,,Reviewed,P00533,No,No,No,No,48,218.58999999999997
+148,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCOCCOCCn2cc(CN3CCN(c4ccc(Nc5cc6c(N7CCC(CO)CC7)nc(Nc7ccc(F)cc7)nc6cn5)nc4)CC3)nn2)C(C)(C)C)cc1,Active,No,HCC827,5.9161200000000065,"Degredation profile isn't concentration dependent, structure with the ligand was modeled by docking. IC50 of the ligand is between 1nM-34 nM (depends on EGFR mutant). EC50 of ligand is between 0.044uM-1.06 uM (cell line depandant)",Ronen Gabizon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,21,6,< 34 nM,,compound 1,CN(C)C1CCN(c2ccc(Nc3cc4c(N5CCC(CO)CC5)nc(Nc5ccc(F)cc5)nc4cn3)nc2)CC1,CCOCCOCCn1cc(CN)nn1,Other,15,6,8,1155.4199999999992,No,,,,31951960,14,No,,Reviewed,P00533,No,No,No,No,48,249.29999999999995
+149,CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)ncc1Cl,Active,Yes,"MOLT-4, MOLM14",3.584000000000003,"General kinase PROTAC, DCmax is for the most degraded kinase. IC50 of the ligand is for 193 kinases in the panel. IC50 of the PROTAC is by FLT3 kinase activity.",Ronen Gabizon,< 100 nM,> 85 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,5,< 1 uM,10.3 nM,TL13-87,CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl,COCCOCCNC(C)=O,Other,11,4,6,931.4729999999998,"INCENP, NDUFAB1, CCNH, CCNK, and IKZF1",,2XB7,GUI,29129717,TL12-186,Yes,,Reviewed,"O14976, O75385, P06239, P07332, P11802, P16591, P24941, P30291, P35991, P36888, P42680, P50613, P50750, P51451, P53671, Q00534, Q00537, Q05397, Q08881, Q13131, Q14004, Q14289, Q2M2I8, Q7KZI7, Q91820, Q96GD4, Q96SZ6, Q9NYV4",Yes,No,Yes,Yes,4,233.59999999999997
+150,CC(C)(C)/C(O)=C/C(=N)N[N+](=O)Nc1ccc(-c2cn3c(n2)sc2cc(OCCN4CCN(C(=O)CCC(=O)NCCCCNC(=O)COc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ccc23)cc1,Inactive,No,"MOLM14, MV4-11",4.0876700000000055,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,16,7,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCCNC(=O)CCC(=O)N1CCN(CCO)CC1,Other,25,9,11,1048.1729999999995,No,,4XUF,P30,29129717,JB-4-048,No,,Reviewed,P36888,No,No,No,No,12,289.28
+151,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(C(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",4.991300000000007,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,19,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCOCCOCCOCCCNC(=O)CCC(=O)N1CCN(CCO)CC1,Other,34,12,20,1176.3199999999995,No,,4XUF,P30,29129717,JB-4-050,No,,Reviewed,P36888,No,No,No,No,12,295.9099999999999
+152,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCCCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",6.195100000000005,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,16,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCCCCCCNC(=O)CN1CCN(CCO)CC1,Other,26,8,14,1058.2319999999995,No,,4XUF,P30,29129717,JB-4-072,No,,Reviewed,P36888,No,No,No,No,12,251.14999999999998
+153,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCOCCOCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",5.187000000000003,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,15,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,CC(=O)NCCOCCOCCO,PEG,13,5,8,891.964,No,,4XUF,P30,29129717,TL13-148,No,,Reviewed,P36888,No,No,No,No,12,236.82999999999998
+154,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(C(=O)CCC(=O)NCCCCCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",6.501900000000006,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,16,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCCCCCCNC(=O)CCC(=O)N1CCN(CCO)CC1,Other,29,9,15,1100.2689999999996,No,,4XUF,P30,29129717,JB-4-049,No,,Reviewed,P36888,No,No,No,No,12,268.21999999999997
+155,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",4.634700000000004,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,16,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCCNC(=O)CN1CCN(CCO)CC1,Other,22,8,10,1002.1239999999997,No,,4XUF,P30,29129717,JB-4-066,No,,Reviewed,P36888,No,No,No,No,12,251.14999999999998
+156,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CC(=O)NCCCOCCOCCOCCCNC(=O)COc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Inactive,No,"MOLM14, MV4-11",4.684500000000006,IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines,Ronen Gabizon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,19,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,O=C(CO)NCCCOCCOCCOCCCNC(=O)CN1CCN(CCO)CC1,Other,31,11,19,1134.2829999999997,No,,4XUF,P30,29129717,JB-4-073,No,,Reviewed,P36888,No,No,No,No,12,278.84
+157,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCN(CCOCCOCCNC(=O)CNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)ccc34)cc2)no1,Active,No,"MOLM14, MV4-11",4.804600000000004,Dmax is difficult to quantify because AC220 raises FLT3 expression levels. IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines. EC50 of PROTAC was measured on MOLM-14 cell lines.,Ronen Gabizon,< 10 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,CC(=O)NCCOCCOCCN1CCN(CCO)CC1,Other,21,7,11,1004.1399999999998,"No; confirmed that AURKA, BTK and PTK2B are not degraded",,4XUF,P30,29129717,TL13-117,No,,Reviewed,P36888,No,No,No,No,12,243.31
+158,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCOCCOCCOCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)ccc34)cc2)no1,Active,No,"MOLM14, MV4-11",5.203600000000003,Dmax is difficult to quantify because AC220 raises FLT3 expression levels. IC50 of ligand is 1.6 nM (binding); 1.1-4 (activity). EC50 of ligand is measured on MOLM-14 cell lines. EC50 of PROTAC was measured on MOLM-14 cell lines.,Ronen Gabizon,< 10 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,16,5,< 1.6 nM,,AC220,CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3ccccc34)cc2)no1,CC(=O)NCCOCCOCCOCCO,PEG,16,6,11,936.017,"No; confirmed that AURKA, BTK and PTK2B are not degraded",,4XUF,P30,29129717,TL13-149,No,,Reviewed,P36888,No,No,No,No,12,246.06
+159,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl,Active,No,"MOLM14, MV4-11",5.107080000000004,IC50 of ligand is inhibitory - data from Selleckchem. EC50 of the lidand is Src-dependent cell proliferation - data from Selleckchem.,Ronen Gabizon,~ 100 nM,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,1.2 nM,,Bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCOCCOC,Other,7,2,4,903.8209999999998,No,,3UE4,DB8,29129717,CJH-005-067,No,,Reviewed,Q06187,No,No,No,No,4,196.92
+160,Cc1cc(C2CC2)cc2ccn(-c3cccc(-c4cc(Nc5ccc(N6CCN(CCOCCOCCNC(=O)CNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)cn5)c(=O)n(C)c4)c3CO)c(=O)c12,Active,Yes,MOLM14,3.957820000000005,IC50 of ligand is 4 nM (BTK inhibition)/ 0.3 nM (binding). EC50 of ligand is 20-30 nM (B-cell signaling).,Ronen Gabizon,< 40 nM,~ 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,5,< 4 nM,,RN486,CN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1,COCCOCCNC(C)=O,Other,11,4,6,1033.1559999999997,No,,4OTR,2V3,29129717,DD-04-015,No,,Reviewed,Q06187,No,No,No,No,4,238.76999999999995
+161,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,6.459820000000005,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCCO,non-PEG polyether,9,3,6,977.0399999999995,No,,4IM0,1FV,28692295,3a,No,,Reviewed,Q9UHD2,No,No,No,No,16,200.24
+162,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,5.696220000000006,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,14,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCO,PEG,10,4,7,993.0389999999995,No,,4IM0,1FV,28692295,3b,No,,Reviewed,Q9UHD2,No,No,No,No,16,209.47000000000003
+163,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,7.240020000000006,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCCCCCOCCO,non-PEG polyether,11,3,8,1005.0939999999996,No,,4IM0,1FV,28692295,3c,No,,Reviewed,Q9UHD2,No,No,No,No,16,200.24
+164,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,6.476420000000005,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,14,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCO,non-PEG polyether,12,4,9,1021.0929999999995,No,,4IM0,1FV,28692295,3d,No,,Reviewed,Q9UHD2,No,No,No,No,16,209.47000000000003
+165,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,5.712820000000005,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCOCCO,PEG,13,5,10,1037.0919999999994,No,,4IM0,1FV,28692295,3e,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+166,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.256620000000007,,Paul Gehrtz,88 nM,79 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,14,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCCO,non-PEG polyether,14,4,11,1049.1469999999995,No,,4IM0,1FV,28692295,3f,No,,Reviewed,Q9UHD2,No,No,No,No,16,209.47000000000003
+167,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,6.493020000000006,,Paul Gehrtz,71 nM,86 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCOCCCCO,non-PEG polyether,15,5,12,1065.1459999999993,No,,4IM0,1FV,28692295,3g,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+168,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,5.729420000000008,,Paul Gehrtz,103 nM,92 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,16,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCOCCOCCO,PEG,16,6,13,1081.144999999999,No,,4IM0,1FV,28692295,3h,No,,Reviewed,Q9UHD2,No,No,No,No,16,227.93
+169,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,Yes,"Panc02.13, H23, A549, H1792, H2110, HCC827",7.2732200000000065,,Paul Gehrtz,12 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,4.6 nM,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1093.1999999999991,No,,4IM0,1FV,28692295,3i,No,,Reviewed,Q9UHD2,Yes,No,No,Yes,16,218.7
+170,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,8.817020000000003,,Paul Gehrtz,95 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,14,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCCCCCOCCCCOCCCCO,non-PEG polyether,18,4,15,1105.254999999999,No,,4IM0,1FV,28692295,3j,No,,Reviewed,Q9UHD2,No,No,No,No,16,209.47000000000003
+171,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,5.7460200000000095,,Paul Gehrtz,29 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,17,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCOCCOCCOCCO,PEG,19,7,16,1125.197999999999,No,,4IM0,1FV,28692295,3k,No,,Reviewed,Q9UHD2,No,No,No,No,16,237.15999999999997
+172,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCCCOCCCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.289820000000007,,Paul Gehrtz,6 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,16,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCCCOCCCCOCCO,non-PEG polyether,20,6,17,1137.2529999999988,No,,4IM0,1FV,28692295,3l,No,,Reviewed,Q9UHD2,No,No,No,No,16,227.93
+173,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCOCCCOCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.679920000000007,,Paul Gehrtz,25 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,16,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCCOCCCOCCCOCCCOCCCO,non-PEG polyether,21,6,18,1151.279999999999,No,,4IM0,1FV,28692295,3m,No,,Reviewed,Q9UHD2,No,No,No,No,16,227.93
+174,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,5.762620000000012,,Paul Gehrtz,34 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,18,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCOCCOCCOCCOCCO,PEG,22,8,19,1169.2509999999993,No,,4IM0,1FV,28692295,3n,No,,Reviewed,Q9UHD2,No,No,No,No,16,246.39
+175,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCCCOCCCCOCCOCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.306420000000007,,Paul Gehrtz,3 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,17,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCOCCCCOCCCCOCCOCCO,non-PEG polyether,23,7,20,1181.3059999999991,No,,4IM0,1FV,28692295,3o,No,,Reviewed,Q9UHD2,No,No,No,No,16,237.15999999999997
+176,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCOCCCCOCCCCOCCCCOCCCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,10.427219999999995,,Paul Gehrtz,292 nM,76 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,17,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCCCOCCCCOCCCCOCCCCOCCCCCO,non-PEG polyether,31,7,28,1293.521999999999,No,,4IM0,1FV,28692295,3p,No,,Reviewed,Q9UHD2,No,No,No,No,16,237.15999999999997
+177,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3nccc(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Inactive,No,Panc02.13,6.510720000000005,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,725 nM,1b analog,CN(CCCNc1ccnc(Nc2ccccc2)n1)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1014.3039999999994,No,,4IM0,1FV,28692295,5a,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+178,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(F)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,6.649820000000005,,Paul Gehrtz,282 nM,74 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,103.5 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1F)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1032.2939999999994,No,,4IM0,1FV,28692295,5b,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+179,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Cl)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.164120000000007,,Paul Gehrtz,10 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,10.4 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1Cl)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1048.7489999999993,No,,4IM0,1FV,28692295,5c,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+180,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(I)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.115320000000006,,Paul Gehrtz,3 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,4 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1I)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1140.1999999999991,No,,4IM0,1FV,28692295,5d,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+181,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.529520000000007,,Paul Gehrtz,29 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,13 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1C(F)(F)F)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1082.3009999999992,No,,4IM0,1FV,28692295,5e,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+182,Cc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1,Active,No,Panc02.13,6.81914000000001,,Paul Gehrtz,92 nM,89 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,270 nM,1b analog,Cc1cnc(Nc2ccccc2)nc1NCCCN(C)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1028.3309999999994,No,,4IM0,1FV,28692295,5f,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.70000000000002
+183,CCc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1,Active,No,Panc02.13,7.073120000000009,,Paul Gehrtz,121 nM,77 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,275 nM,1b analog,CCc1cnc(Nc2ccccc2)nc1NCCCN(C)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1042.3579999999995,No,,4IM0,1FV,28692295,5g,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.70000000000002
+184,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(C4CCC4)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.778220000000006,,Paul Gehrtz,544 nM,70 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,1035 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1C1CCC1)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1068.395999999999,No,,4IM0,1FV,28692295,5h,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+185,C=Cc1cnc(Nc2ccc(OCCCOCCCCOCCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)nc1NCCCN(C)C(=O)C1CCC1,Active,No,Panc02.13,7.153720000000008,,Paul Gehrtz,48 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,130 nM,1b analog,C=Cc1cnc(Nc2ccccc2)nc1NCCCN(C)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1040.3419999999996,No,,4IM0,1FV,28692295,5i,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.70000000000002
+186,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(C4CC4)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)(C)C)cc1,Active,No,Panc02.13,7.388120000000006,,Paul Gehrtz,65 nM,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,5,,245 nM,1b analog,CN(CCCNc1nc(Nc2ccccc2)ncc1C1CC1)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1054.3689999999992,No,,4IM0,1FV,28692295,5j,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+187,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CNC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)cc1,Inactive,No,Panc02.13,5.858520000000004,,Paul Gehrtz,> 1000 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)CN)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1037.0919999999994,No,,4IM0,1FV,28692295,6a,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+188,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C)NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)cc1,Active,No,Panc02.13,6.247020000000005,,Paul Gehrtz,> 1000 nM,34 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C)N)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1051.1189999999995,No,,4IM0,1FV,28692295,6b,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+189,CC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1,Active,No,Panc02.13,6.637120000000007,,Paul Gehrtz,864 nM,71 %,CC[C@H](N)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1065.1459999999993,No,,4IM0,1FV,28692295,6c,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+190,CCC[C@H](NC(=O)COCCCOCCCCOCCCOc1ccc(Nc2ncc(Br)c(NCCCN(C)C(=O)C3CCC3)n2)cc1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1,Active,No,Panc02.13,7.027220000000007,,Paul Gehrtz,288 nM,75 %,CCC[C@H](N)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1079.172999999999,No,,4IM0,1FV,28692295,6d,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+191,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCOCCCOc2ccc(Nc3ncc(Br)c(NCCCN(C)C(=O)C4CCC4)n3)cc2)C(C)C)cc1,Active,No,Panc02.13,6.883120000000006,,Paul Gehrtz,44 nM,88 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)C)cc1,VHL,,,aryl_O,15,5,,,1b,CN(CCCNc1nc(Nc2ccccc2)ncc1Br)C(=O)C1CCC1,O=CCOCCCOCCCCOCCCO,non-PEG polyether,17,5,14,1079.1729999999993,No,,4IM0,1FV,28692295,6e,No,,Reviewed,Q9UHD2,No,No,No,No,16,218.7
+192,Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)c3)s2)n1,Active,Yes,HeLa,3.418640000000001,,Shimrit Azulay,,~ 39 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,16,3,,0.25 uM,sirtuin rearranging ligand,COc1cccc(Cc2cnc(NC(=O)CSc3nc(C)cc(C)n3)s2)c1,O=C(CO)NCCCCn1ccnn1,Other,14,6,6,852.956,No,,,,28379698,Compound 12,No,,Reviewed,Q8IXJ6,No,Yes,No,Yes,"1,3,6",229.58999999999997
+193,O=C1CCC(N2C(=O)c3cccc(OCCCCCOc4ccc(CC(=O)Nc5cc(C6CCC6)[nH]n5)cc4)c3C2=O)C(=O)N1,Active,Yes,HCT116,3.8877000000000015,,Rambabu Reddi,,~ 65 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,8,3,,,compound 1,COc1ccc(CC(=O)Nc2cc(C3CCC3)[nH]n2)cc1,CCCCO,Alkane,5,1,2,613.6710000000003,"no off targets. Selective for CDK 9 over CDK2, CDK5, FAK, Akt and IKKβ",,,,28636052,Compound 3,No,,Reviewed,P50750,Yes,Yes,No,No,6,159.79
+194,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)C(C)(C)C)C(C)(C)C)cc1,Active,Yes,Human THP-1 monocytes,6.846520000000008,PROTAC_ERRα is efficacious in mice,Amit Shraga,1.4 nM,> 95 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,17,4,,,Vandetanib,CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1,O=CCOCCOCCOCCOCCO,PEG,16,6,13,1060.3309999999997,BCR,,5J79,6GE,26075522,PROTAC_RIPK2,Yes,,Reviewed,O43353,Yes,Yes,No,Yes,16,229.72999999999996
+195,COc1cc(C=C2SC(=O)N(CCOCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)C2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,Active,Yes,MCF-7 breast cancer cells,7.062000000000007,"protein reduction by nearly 50% was observed as early as 1 h post‐treatment, and almost complete degradation was achieved after 4 h of treatment",Amit Shraga,~ 100 nM,86 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,13,3,,,compound 29 thiazolidinedione-based ligand,COc1cc(/C=C2\SC(=O)N(C)C2=O)ccc1Oc1ccc(C#N)cc1C(F)(F)F,COCCC=O,PEG,6,2,3,949.0429999999999,"RIPK3, NLK, ABL1/BCR-­ABL, TESK2, TGFBR2, TGFBR2",,,,26075522,PROTAC_ERRα,Yes,,Reviewed,P11474,Yes,No,No,Yes,8,200.48999999999995
+196,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCOCCOCC(=O)Nc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)CC1,Active,Yes,NAMALWA,3.9376000000000015,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Amit Shraga,7.9 nM,95 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCOCC(N)=O,PEG,11,5,7,773.8509999999999,No,,5P9J,"8E8",31879210,SJF620,No,29851337,Reviewed,Q06187,No,No,No,No,24,196.13
+197,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCCCCCOCCOCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,No,NAMALWA,5.138200000000003,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,80.6 nM,96 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCCCCCOCCOCC=O,non-PEG polyether,14,4,11,843.942,No,,5P9J,"8E8",29851337,MT-540,No,,Reviewed,Q06187,No,No,No,No,,213.2
+198,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCCCOCCCCOCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,No,NAMALWA,5.138200000000003,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,90.1 nM,93 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCCCOCCCCOCC=O,non-PEG polyether,14,4,11,843.942,No,,5P9J,"8E8",29851337,MT-541,No,,Reviewed,Q06187,No,No,No,No,,213.2
+199,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCCOCCCOCCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,No,NAMALWA,4.748100000000003,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,68.3 nM,95 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCCOCCCOCCC=O,non-PEG polyether,13,4,10,829.9150000000001,No,,5P9J,"8E8",29851337,MT-781,No,,Reviewed,Q06187,No,No,No,No,,213.2
+200,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCOCCOCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Inactive,No,NAMALWA,3.5778000000000008,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCOCC=O,PEG,10,4,7,787.834,No,,5P9J,"8E8",29851337,MT-797,No,,Reviewed,Q06187,No,No,No,No,,213.2
+201,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCOCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Inactive,No,NAMALWA,3.5612000000000013,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCC=O,PEG,7,3,4,743.781,No,,5P9J,"8E8",29851337,MT-783,No,,Reviewed,Q06187,No,No,No,No,,203.96999999999997
+202,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCOCCOCC(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,Yes,"NAMALWA, XLA",3.5778000000000008,"DC50 is 9.1 nM (WT BTK, NAMALWA cells), 14.6 nM (WT BTK, XLA cells), 14.9 nM (C481S, XLA cells). IC50 of PROTAC is 46.9 (WT BTK), 20.9 (C481S). IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,< 14.9 nM,> 99 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,< 46.9 nM,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCOCC=O,PEG,10,4,7,787.834,"Significant binding to: TEC, ERBB2, ERBB3, HCK, YES, BRK, LCK, BLK, CSK, RIPK2, MEK5, CSNK1E",,5P9J,"8E8",29851337,MT-802,Yes,,Reviewed,Q06187,Yes,Yes,Yes,Yes,"1,2,4,8,16,24",213.2
+203,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(CCCCOCCCCOCC(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,No,NAMALWA,5.138200000000003,"IC50 of ligand is 51.0 nM (WT BTK), 30.7 (C481S)",Barr Tivon,11.6 nM,> 99 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,< 51.0 nM,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCCCOCCCCOCC=O,non-PEG polyether,14,4,11,843.942,No,,5P9J,"8E8",29851337,MT-809,No,,Reviewed,Q06187,No,No,No,No,,213.2
+204,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2,Active,Yes,"MV4;11, SUM149, SUM159, MOLM13, MM1.SCRBN−/−, MM1.SW",3.6824600000000025,,Daniel Zaidman,430 nM,95 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,12,3,28 nM,20 nM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCCNC(=O)CO,Alkane,10,4,5,785.2829999999999,"BRD2, BRD3, BRD4",,3MXF,JQ1,25999370,dBET1,Yes,,Reviewed,O60885,No,Yes,Yes,Yes,"1,2,4,8,16,24",194.05
+205,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1,Active,Yes,"MV4;11, 293FT, 293FTCRBN−/−",4.518800000000005,,Daniel Zaidman,10 nM,50 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,14,4,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,O=CCCC(=O)NCCCCNC(=O)CO,Alkane,16,6,9,1009.1229999999994,No,,,,25999370,dFKBP-1,No,,Reviewed,P62942,No,Yes,No,Yes,18,262.21999999999997
+206,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1,Active,No,"MV4;11, 293FT, 293FTCRBN−/−",4.56860000000001,,Daniel Zaidman,< 10 nM,60 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,17,4,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,O=CCCC(=O)NCCCOCCOCCOCCCNC(=O)CO,PEG,25,9,18,1141.2819999999992,No,,,,25999370,dFKBP-2,No,,Reviewed,P62942,No,Yes,No,Yes,18,289.90999999999997
+207,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,9.372140000000005,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,5,0.86 nM,4.3 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCCOCCCCCC=O,non-PEG polyether,19,4,16,1194.558,No,,2HYY,STI,26593377,IMA-6-2-2-6-VHL,No,,Reviewed,P00519,No,No,No,No,24,225.59999999999997
+208,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,7.795140000000011,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,0.86 nM,5.8 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCC=O,non-PEG polyether,12,3,9,1094.397,No,,2HYY,STI,26593377,IMA-6-2-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,216.37
+209,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,7.861540000000015,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,19,5,0.86 nM,1.7 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,24,7,21,1270.6090000000002,No,,2HYY,STI,26593377,IMA-6-(2-)5-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,253.29000000000002
+210,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,10.525839999999999,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,0.86 nM,19 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCCCCOCCCCCC=O,non-PEG polyether,19,3,16,1192.586,No,,2HYY,STI,26593377,IMA-6-5-6-VHL,No,,Reviewed,P00519,No,No,No,No,24,216.37
+211,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCCOCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,7.171020000000007,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,4,0.86 nM,6.2 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCCOCCCCCC=O,non-PEG polyether,19,4,16,1037.232,No,,2HYY,STI,26593377,IMA-6-2-2-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,226.61999999999995
+212,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,5.594020000000004,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,4,0.86 nM,4.7 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCC=O,non-PEG polyether,12,3,9,937.0709999999998,No,,2HYY,STI,26593377,IMA-6-2-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,217.39
+213,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,5.660420000000009,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,18,4,0.86 nM,3.0 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,24,7,21,1113.283,No,,2HYY,STI,26593377,IMA-6-(2-)5-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,254.31
+214,Cc1ccc(NC(=O)c2ccc(CN3CCN(CCCCCCOCCCCCOCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,Inactive,No,K562 CML,8.324720000000008,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,4,0.86 nM,24 nM,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCOCCCCCOCCCCCC=O,non-PEG polyether,19,3,16,1035.26,No,,2HYY,STI,26593377,IMA-6-5-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,217.39
+215,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCCOCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)c(OC)cc23)c(Cl)cc1Cl,Inactive,No,K562 CML,9.9722,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,4,0.063 nM,1.4 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCCOCCCCCC=O,non-PEG polyether,19,4,16,1231.3989999999994,No,,3UE4,DB8,26593377,BOS-6-2-2-6-VHL,No,,Reviewed,P00519,No,No,No,No,24,222.19999999999996
+216,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)c(OC)cc23)c(Cl)cc1Cl,Inactive,No,K562 CML,8.39520000000001,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,0.063 nM,1.3 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCC=O,non-PEG polyether,12,3,9,1131.2379999999998,No,,3UE4,DB8,26593377,BOS-6-2-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,212.97
+217,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)c(OC)cc23)c(Cl)cc1Cl,Inactive,No,K562 CML,8.461600000000011,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,20,4,0.063 nM,0.57 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,24,7,21,1307.4499999999991,No,,3UE4,DB8,26593377,BOS-6-(2-)5-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,249.88999999999996
+218,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)c(OC)cc23)c(Cl)cc1Cl,Inactive,No,K562 CML,11.125899999999994,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,0.063 nM,4.6 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCCCCOCCCCCC=O,non-PEG polyether,19,3,16,1229.4269999999995,No,,3UE4,DB8,26593377,BOS-6-5-6-VHL,No,,Reviewed,P00519,No,No,No,No,24,212.97
+219,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCCOCCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl,Active,No,K562 CML,7.771080000000009,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,3,0.063 nM,0.91 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCCOCCCCCC=O,non-PEG polyether,19,4,16,1074.0729999999996,No,,3UE4,DB8,26593377,BOS-6-2-2-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,223.21999999999997
+220,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl,Active,No,K562 CML,6.194080000000006,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,0.063 nM,0.28 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCC=O,non-PEG polyether,12,3,9,973.9119999999999,No,,3UE4,DB8,26593377,BOS-6-2-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,213.98999999999998
+221,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl,Active,No,K562 CML,6.260480000000008,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,19,3,0.063 nM,0.38 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,24,7,21,1150.1239999999996,No,,3UE4,DB8,26593377,BOS-6-(2-)5-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,250.90999999999997
+222,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(CCCCCCOCCCCCOCCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)c(OC)cc23)c(Cl)cc1Cl,Active,No,K562 CML,8.924780000000005,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,0.063 nM,2.8 nM,bosutinib,COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl,CCCCCOCCCCCOCCCCCC=O,non-PEG polyether,19,3,16,1072.1009999999997,No,,3UE4,DB8,26593377,BOS-6-5-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,213.98999999999998
+223,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562 CML,7.155860000000007,c-ABL degredation,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,16,5,0.030 nM,0.36 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCC=O,non-PEG polyether,11,3,8,1058.773,No,,2GQG,1N1,26593377,DAS-6-2-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,216.36999999999995
+224,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562 CML,7.22226000000001,c-ABL degredation,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,20,5,0.030 nM,0.28 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,23,7,20,1234.984999999999,No,,2GQG,1N1,26593377,DAS-6-(2-)5-2-VHL,No,,Reviewed,P00519,No,No,No,No,24,253.28999999999996
+225,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCCCCOCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)n1,Active,No,K562 CML,9.886559999999998,c-ABL degredation,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,hydroxyl_to_carbon,16,5,0.030 nM,2.6 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCCCCOCCCCCC=O,non-PEG polyether,18,3,15,1156.961999999999,No,,2GQG,1N1,26593377,DAS-6-5-6-VHL,No,,Reviewed,P00519,No,No,No,No,24,216.36999999999995
+226,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCCOCCCCCC(=O)Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n1,Active,No,K562 CML,6.531740000000005,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,16,4,0.030 nM,0.60 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCCOCCCCCC=O,non-PEG polyether,18,4,15,1001.6079999999994,No,,2GQG,1N1,26593377,DAS-6-2-2-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,226.62
+227,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCC(=O)Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n1,Active,Yes,K562 CML,4.954740000000003,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,15,4,0.030 nM,0.28 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCC=O,non-PEG polyether,11,3,8,901.4469999999998,No,,2GQG,1N1,26593377,DAS-6-2-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,217.39
+228,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCOCCOCCOCCOCCOCC(=O)Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n1,Active,No,K562 CML,5.021140000000004,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,19,4,0.030 nM,0.26 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCOCCOCCOCCOCCOCC=O,non-PEG polyether,23,7,20,1077.6589999999997,No,,2GQG,1N1,26593377,DAS-6-(2-)5-2-CRBN,No,,Reviewed,P00519,No,No,No,No,24,254.31
+229,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCCCCOCCCCCOCCCCCC(=O)Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n1,Active,No,K562 CML,7.685440000000007,c-ABL and BCR-ABL degredation,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,15,4,0.030 nM,1.3 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOCCCCCOCCCCCC=O,non-PEG polyether,18,3,15,999.6359999999993,No,,2GQG,1N1,26593377,DAS-6-5-6-CRBN,No,,Reviewed,P00519,No,No,No,No,24,217.39
+230,COc1cc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)ccc1OC(=O)NCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,2.2327700000000004,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,5,7.9 nM,13.5 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,NCCCCNC(=O)CO,Alkane,10,4,5,889.9659999999997,No,,,,28418626,1,No,,Reviewed,Q9H8M2,No,No,No,No,4,261.46
+231,COc1cc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)ccc1OC(=O)NCCCCCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,3.7931700000000026,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,5,7.9 nM,18.9 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,NCCCCCCCCNC(=O)CO,Alkane,14,4,9,946.0739999999994,No,,,,28418626,2,No,,Reviewed,Q9H8M2,No,No,No,No,4,261.46
+232,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCCOCCOCCOCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,1.6891700000000072,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,18,5,7.9 nM,36.5 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,O=CNCCCOCCOCCOCCCNC(=O)CO,PEG,21,8,16,1036.1519999999994,No,,,,28418626,S1,No,,Reviewed,Q9H8M2,No,No,No,No,4,289.15
+233,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCCCCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,3.303370000000002,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,14,4,7.9 nM,30 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,O=CNCCCCCCO,Alkane,10,3,7,874.9949999999997,No,,,,28418626,3,No,,Reviewed,Q9H8M2,No,No,No,No,4,232.35999999999999
+234,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)N1CCC(C2CCN(C(=O)Oc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1,Active,No,MOLM-13,3.697370000000002,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,15,3,7.9 nM,12.5 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,O=CN1CCC(C2CCN(C(=O)O)CC2)CC1,Other,17,5,2,970.0959999999994,No,,,,28418626,S2,No,,Reviewed,Q9H8M2,No,No,No,No,4,243.88
+235,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCOCCOCCOCCN[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Inactive,No,MOLM-13,4.02699000000001,,Adi Rogel,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,18,6,7.9 nM,26.9 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,CCOCCOCCOCCNC=O,PEG,14,5,11,1107.387999999999,No,,,,28418626,S3,No,,Reviewed,Q9H8M2,No,No,No,No,4,261.83
+236,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCOCCOCCN[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Inactive,No,MOLM-13,4.010390000000009,,Adi Rogel,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,6,7.9 nM,22.7 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,CCOCCOCCNC=O,PEG,11,4,8,1063.3349999999991,No,,,,28418626,S4,No,,Reviewed,Q9H8M2,No,No,No,No,4,252.59999999999997
+237,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCCCCCCCNc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,4.116670000000003,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,14,5,7.9 nM,11.5 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,NCCCCCCCCNC=O,Alkane,12,3,9,902.0649999999995,No,,,,28418626,S5,No,,Reviewed,Q9H8M2,No,No,No,No,4,235.16
+238,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,4.116670000000003,,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,5,7.9 nM,15.5 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,CCCCCCCCNC=O,Alkane,11,2,8,902.0649999999995,No,,,,28418626,4,No,,Reviewed,Q9H8M2,No,No,No,No,4,235.16
+239,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OCC(=O)NCCCCCCCCNc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,4.476470000000003,,Adi Rogel,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,5,7.9 nM,12.3 nM,analog of I-BRD9,COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC,CCCCCCCCNC=O,Alkane,11,2,8,888.0819999999994,"BET bromodomains (BRD4, BRD7)",,,,28418626,5,Yes,,Reviewed,Q9H8M2,No,Yes,No,Yes,4,218.09
+240,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCCCCCNc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,MOLM-13,3.2394000000000016,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,12,3,,56.6 nM,BI-7273,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,NCCCCCCNC=O,Alkane,10,3,7,751.8410000000002,No,,5EU1,5SW,28418626,S6,No,,Reviewed,Q9H8M2,No,No,No,No,4,181.27
+241,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,MOLM-13,4.019600000000002,,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,3,,83.1 nM,BI-7273,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CCCCCCCCNC=O,Alkane,11,2,8,779.8950000000002,No,,5EU1,5SW,28418626,S7,No,,Reviewed,Q9H8M2,No,No,No,No,4,181.27
+242,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Inactive,No,MOLM-13,3.456520000000011,,Adi Rogel,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,,43.2 nM,BI-7273,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,O=CCOCCOCCOCCNC=O,PEG,15,6,12,999.2009999999999,No,,5EU1,5SW,28418626,S8,No,,Reviewed,Q9H8M2,No,No,No,No,4,225.01
+243,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCCCCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,MOLM-13,3.1027000000000022,,Adi Rogel,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,13,3,,48 nM,BI-7273,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,O=CNCCCCCCCCNC(=O)CO,Alkane,16,5,11,837.9310000000002,No,,5EU1,5SW,28418626,S9,No,,Reviewed,Q9H8M2,No,No,No,No,4,207.57000000000002
+244,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)CC(=O)NCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,Yes,MOLM-13,1.7122000000000035,,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,3,,104 nM,BI-7273,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CCOCCOCCNC=O,PEG,11,4,8,783.8390000000002,No,,5EU1,5SW,28418626,6 (dBRD9),No,,Reviewed,Q9H8M2,No,No,No,No,4,199.73000000000002
+245,CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCN(CC(=O)NCCOCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)s2)o1,Active,Yes,MOLT4,3.0507000000000044,tested competition with ligand and with thalidomide. EC for ligand and PROTAC was measured in MOLT-4 cell line.,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,16,4,,,SNS-032,CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1,CCOCCOCCOCCNC(C)=O,PEG,15,5,10,869.0360000000001,No,,,,29251720,thal-sns-032,Yes,,Reviewed,P50750,No,Yes,No,Yes,6,223.63
+246,N#CC1(CNc2cccc(-c3cc(N[C@H]4CC[C@H](NCC(=O)NCCOCCOCCOCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ncc3Cl)n2)CCOCC1,Inactive,No,MOLT4,3.9113800000000056,EC50 of ligand is measured on MOLT-4 cell line,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,6,< 0.514 nM,,NVP-2,COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1,CCCOCCOCCOCCN,PEG,13,4,10,943.5029999999997,No,,,,29251720,thal-nvp-2-03-009 (4),No,,Reviewed,P50750,No,No,No,No,6,247.25999999999996
+247,N#CC1(CNc2cccc(-c3cc(N[C@H]4CC[C@H](NCCCCCCNc5cccc6c5C(=O)C(C5CCC(=O)NC5=O)C6=O)CC4)ncc3Cl)n2)CCOCC1,Active,No,MOLT4,6.562480000000007,achieved full degradation after 24hrs with addition of off-target CDK10 degradation. EC50 of ligand is measured on MOLT-4 cell line,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,5,< 0.514 nM,,NVP-2,COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1,O=CNC=O,Alkane,5,3,2,795.3849999999999,CDK10 after 24hr treatment,,,,29251720,thal-nvp-2-03-069 (5),No,,Reviewed,P50750,No,No,No,No,"6,24",187.22999999999993
+248,N#CC1(CNc2cccc(-c3cc(N[C@H]4CC[C@H](NCCCCCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ncc3Cl)n2)CCOCC1,Inactive,No,MOLT4,5.031880000000003,EC50 of ligand is measured on MOLT-4 cell line,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,6,< 0.514 nM,,NVP-2,COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1,CCCCNC(C)=O,Alkane,8,2,3,853.4249999999996,No,,,,29251720,thal-nvp-2-03-084 (6),No,,Reviewed,P50750,No,No,No,No,6,219.56999999999996
+249,N#CC1(CNc2cccc(-c3cc(N[C@H]4CC[C@H](NCCCC(=O)NCCCCOc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ncc3Cl)n2)CCOCC1,Inactive,No,MOLT4,4.9987800000000036,EC50 of ligand is measured on MOLT-4 cell line,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,< 0.514 nM,,NVP-2,COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1,CC(=O)NCCCCO,Alkane,9,3,4,854.4089999999997,No,,,,29251720,thal-nvp-2-03-105 (7),No,,Reviewed,P50750,No,No,No,No,6,216.76999999999995
+250,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCN(C(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)c12,Active,No,,5.187620000000016,,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,morpholine_to_piperazine,21,4,19 nM,,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,NC(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)CO,PEG,26,10,18,1465.695,No,,,,31117518,dMCL1-1,No,,Reviewed,Q07820,No,No,No,No,,324.5899999999999
+251,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCN(C(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)c12,Active,Yes,OPM2,5.345020000000006,,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,morpholine_to_piperazine,16,2,19 nM,30 nM,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,NC(=O)CO,Alkane,5,3,1,1163.3239999999998,No,,,,31117518,dMCL1-2,No,,Reviewed,Q07820,No,No,No,Yes,48,238.69999999999996
+252,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)NCCCCNC(=O)COc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)n(CCN3CCOCC3)c12,Inactive,No,,5.461020000000008,,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,carboxilic_acid_to_amide,17,3,19 nM,,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,NCCCCNC(=O)CO,Alkane,10,4,5,1234.4470000000001,No,,,,31117518,dMCL1-3,No,,Reviewed,Q07820,No,No,No,No,,248.51999999999998
+253,Cc1nn(C)c(COc2ccc(N3CCN(C(=O)CCNC(=O)CCCOCCOCCOCCCNC(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,Active,No,,6.095820000000015,modest to poor activity,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,20,4,19 nM,,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,O=CCCNC(=O)CCCOCCOCCOCCCNC(=O)CO,PEG,25,9,18,1359.545,No,,,,31117518,dMCL1-4,No,,Reviewed,Q07820,No,No,No,No,,293.2
+254,Cc1nn(C)c(COc2ccc(N3CCN(C(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,Active,No,,6.253220000000007,modest to poor activity,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,2,19 nM,,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,O=CCO,Alkane,4,2,1,1057.1739999999998,No,,,,31117518,dMCL1-5,No,,Reviewed,Q07820,No,No,No,No,,207.30999999999997
+255,Cc1nn(C)c(COc2ccc(N3CCN(C(=O)CCCNC(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,Active,No,,6.149620000000007,modest to poor activity,Barr Tivon,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,16,3,19 nM,,A-1210477,Cc1nn(C)c(COc2ccc(N3CCN(S(=O)(=O)N(C)C)CC3)cc2)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)n(CCN3CCOCC3)c12,O=CCCCNC(=O)CO,Alkane,10,4,5,1142.2800000000002,No,,,,31117518,dMCL1-6,No,,Reviewed,Q07820,No,No,No,No,,236.40999999999997
+256,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCOCCOCCN2CCN(c3cc(-c4ccccc4O)nnc3N)CC2)c1,Active,No,MV-4-11,3.7085200000000036,"poor cellular permeability, ternary complex crystal structure: 6HAY (VCB:PROTAC 1:SMARCA2). DC50 is SMARCA2 300nM, SMARCA4 250nM. DCmax isSMARCA2 65%, SMARCA4 70%.",Efrat Resnick,< 300 nM,< 70 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,5,,,SMARCABD,Nc1nnc(-c2ccccc2O)cc1N1CCNCC1,CCOCCOCCO,PEG,9,3,6,918.1059999999993,No,,6HAZ,FX5,31178587,PROTAC 1,No,,Reviewed,"P51531, P51532",No,Yes,No,No,,217.83
+257,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCc2ccc(CN3CCN(c4cc(-c5ccccc5O)nnc4N)CC3)cc2)c1,Active,No,,5.418020000000005,"ternary complex crystal structure: 6HAX (VCB:PROTAC 2:SMARCA2BD), 6HAR2 (VCB:PROTAC 2:SMARCA4BD)",Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,13,5,,,SMARCABD,Nc1nnc(-c2ccccc2O)cc1N1CCNCC1,Cc1ccc(CCO)cc1,Other,10,1,2,920.1249999999994,No,,6HAZ,FX5,31178587,PROTAC 2,No,,Reviewed,"P51531, P51532",Yes,Yes,No,No,,199.36999999999998
+258,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCOc2ccc(CN3CCN(c4cc(-c5ccccc5O)nnc4N)CC3)cc2)c1,Active,Yes,"MV-4-11 SK-MEL-5, NCI-H1568",5.254320000000003,"EC50 of PROTAC is 28nM in MV-4-11, 68nM in NCI-H1568. DC50 is (SMARCA2 6nM, SMARCA4 11nM, PBRM1 32nM in MV-4-11; SMARCA2 3.3nM, PBRM1 15.6nM in NCI-H1568)",Efrat Resnick,< 32 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,5,,,SMARCABD,Nc1nnc(-c2ccccc2O)cc1N1CCNCC1,Cc1ccc(OCCO)cc1,Other,11,2,3,936.1239999999995,No,,6HAZ,FX5,31178587,ACBI1,Yes,,Reviewed,"P51531, P51532",Yes,Yes,No,No,18,208.6
+259,C[C@@H]1C[C@@H](O)c2ncnc(C3CCN(C(=O)[C@H](CNCCCCCCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c4ccc(Cl)cc4)CC3)c21,Active,Yes,MDA-MB-468,6.874500000000007,"IC50 of ligand is AKT1 5 nM, AKT2 18 nM, AKT3 8 nM. EC50 of ligand is 0.229-12.9 uM (cell dependant). EC50 of PROTAC is 0.016-1.65 uM (cell dependant). EC50 of PROTAC is AKT1 2 nM, AKT2 6.8 nM, AKT3 3.5 nM.",Rambabu Reddi,2 nM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,8,3,< 18 nM,< 6.8 nM,GDC-0068,CC(C)NC[C@@H](C(=O)N1CCC(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1,CCCCCCCC,Alkane,8,0,5,797.4410000000001,No,,4EKL,0RF,31859249,INY-03-041,Yes,,Reviewed,P31750,Yes,Yes,No,Yes,12,144.82999999999998
+260,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,Inactive,No,PC-3,2.4505999999999997,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,4,4,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,None,Alkane,0,0,0,382.2510000000001,No,,,,31846828,A1,No,,Reviewed,"P24941, P50750",No,No,No,No,12,98.91
+261,O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1,Active,No,PC-3,2.846400000000002,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,10,5,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCCCCCNC(=O)CO,Alkane,12,4,7,809.664,No,,,,31846828,A2,No,,Reviewed,"P24941, P50750",No,No,No,No,12,229.07
+262,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,2.099300000000001,,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,10,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,CCNC(=O)CCC=O,Alkane,9,3,4,780.626,No,,,,31846828,A3,No,,Reviewed,"P24941, P50750",No,No,No,No,12,231.86999999999998
+263,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,2.879500000000001,,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,10,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,CCCCNC(=O)CCC=O,Alkane,11,3,6,808.6799999999998,No,,,,31846828,A4,No,,Reviewed,"P24941, P50750",No,No,No,No,12,231.86999999999998
+264,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,3.6597000000000017,,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,10,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,CCCCCCNC(=O)CCC=O,Alkane,13,3,8,836.7339999999997,No,,,,31846828,A5,No,,Reviewed,"P24941, P50750",No,No,No,No,12,231.86999999999998
+265,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,1.182400000000002,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,11,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCCC(=O)NCCNC(=O)CO,Alkane,14,6,7,838.6619999999999,No,,,,31846828,A6,No,,Reviewed,"P24941, P50750",No,No,No,No,12,258.16999999999996
+266,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,1.9626000000000006,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,11,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCCC(=O)NCCCCNC(=O)CO,Alkane,16,6,9,866.7159999999998,No,,,,31846828,A7,No,,Reviewed,"P24941, P50750",No,No,No,No,12,258.16999999999996
+267,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,2.742800000000001,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,11,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCCC(=O)NCCCCCCNC(=O)CO,Alkane,18,6,11,894.7699999999996,No,,,,31846828,A8,No,,Reviewed,"P24941, P50750",No,No,No,No,12,258.16999999999996
+268,O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1,Active,No,PC-3,1.3192000000000037,Controls were done against CDK2. tested competition with ligand and with pomalidomide,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,12,5,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCOCCOCCNC(=O)CO,PEG,14,6,9,841.662,No,,,,31846828,A9,No,,Reviewed,"P24941, P50750",No,Yes,No,Yes,12,247.52999999999997
+269,O=C(CCC(=O)N1CCC(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)CC1)NCCCOCCOCCOCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,1.622300000000005,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,14,6,,,AT-7519,O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl,O=CCCC(=O)NCCCOCCOCCOCCNC(=O)CO,PEG,24,9,17,984.8479999999995,No,,,,31846828,A10,No,,Reviewed,"P24941, P50750",No,No,No,No,12,285.85999999999996
+270,O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1,Active,No,PC-3,1.697700000000003,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,13,6,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCCNC(=O)CO,Alkane,10,4,5,816.8359999999999,No,,,,31846828,F1,No,,Reviewed,"P24941, P50750",No,No,No,No,12,256.81
+271,O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1,Active,No,PC-3,2.4779000000000027,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,13,6,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCCCCNC(=O)CO,Alkane,12,4,7,844.89,No,,,,31846828,F2,No,,Reviewed,"P24941, P50750",No,No,No,No,12,256.81
+272,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,Yes,PC-3,1.7308000000000008,"preferentially degrades CDK9 over CDK2. Controls were done against CDK2 and CDK9. tested competition with ligand and with pomalidomide. DC50 is CDK2: 62 nM, CDK9: 33 nM.",Ella Livnah,< 62 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,13,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,CCNC(=O)CCC=O,Alkane,9,3,4,815.8519999999997,No,,,,31846828,F3,No,,Reviewed,"P24941, P50750",No,Yes,No,Yes,12,259.61
+273,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,PC-3,2.511000000000001,,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,13,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,CCCCNC(=O)CCC=O,Alkane,11,3,6,843.9059999999996,No,,,,31846828,F4,No,,Reviewed,"P24941, P50750",No,No,No,No,12,259.61
+274,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,PC-3,3.291200000000001,,Ella Livnah,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,13,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,CCCCCCNC(=O)CCC=O,Alkane,13,3,8,871.9599999999995,No,,,,31846828,F5,No,,Reviewed,"P24941, P50750",No,No,No,No,12,259.61
+275,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,PC-3,0.8139000000000034,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,14,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCC(=O)NCCNC(=O)CO,Alkane,14,6,7,873.8879999999997,No,,,,31846828,F6,No,,Reviewed,"P24941, P50750",No,No,No,No,12,285.90999999999997
+276,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,1.5941000000000027,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,14,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCC(=O)NCCCCNC(=O)CO,Alkane,16,6,9,901.9419999999996,No,,,,31846828,F7,No,,Reviewed,"P24941, P50750",No,No,No,No,12,285.90999999999997
+277,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCCCCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,2.3743000000000025,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,14,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCC(=O)NCCCCCCNC(=O)CO,Alkane,18,6,11,929.9959999999994,No,,,,31846828,F8,No,,Reviewed,"P24941, P50750",No,No,No,No,12,285.90999999999997
+278,O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1,Active,No,PC-3,0.9507000000000062,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,15,6,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCOCCOCCNC(=O)CO,PEG,14,6,9,876.8879999999998,No,,,,31846828,F9,No,,Reviewed,"P24941, P50750",No,No,No,No,12,275.27
+279,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCCOCCOCCOCCNC(=O)COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,PC-3,1.2538000000000065,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,17,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,O=CCCC(=O)NCCCOCCOCCOCCNC(=O)CO,PEG,24,9,17,1020.0739999999993,No,,,,31846828,F10,No,,Reviewed,"P24941, P50750",No,No,No,No,12,313.5999999999999
+280,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCNc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Active,No,PC-3,2.0906000000000016,,Ella Livnah,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,12,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,CCNC(=O)CCC=O,Alkane,9,3,4,801.8689999999997,No,,,,31846828,F11,No,,Reviewed,"P24941, P50750",Yes,No,No,No,12,242.54
+281,O=C(CCC(=O)N1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1)NCCNc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,PC-3,1.7308000000000008,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_amide,13,7,,,FN-1501,O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2[nH]ccc12,NCCNC(=O)CCC=O,Alkane,10,4,5,815.8519999999997,No,,,,31846828,F12,No,,Reviewed,"P24941, P50750",No,No,No,No,12,259.61
+282,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Active,No,HeLa,4.357320000000003,,Shimrit Azulay,,47 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,5,45 nM,275 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCCNC=O,Alkane,7,3,4,818.9609999999999,No,,5WUK,73K,31831267,UNC6851,No,,Reviewed,"O75530, Q15022, Q15910",No,No,No,No,24,208.98000000000002
+283,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Active,Yes,"HeLa, DLBCL",4.7474200000000035,DC50 value is for HeLa cells. DC50 is 0.61 uM for DLBCL cells. DMAX value is for HeLa cells. DMAX is 96 % for DLBCL cells.,Shimrit Azulay,0.79 uM,92 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,5,45 nM,247 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCCCNC=O,Alkane,8,3,5,832.9879999999998,"EZH2, SUZ12",,5WUK,73K,31831267,UNC6852,Yes,,Reviewed,"O75530, Q15022, Q15910",Yes,No,No,Yes,24,208.98000000000002
+284,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Inactive,No,HeLa,5.137520000000003,,Shimrit Azulay,,24 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,5,45 nM,368 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCCCCNC=O,Alkane,9,3,6,847.0149999999999,No,,5WUK,73K,31831267,UNC6853,No,,Reviewed,"O75530, Q15022, Q15910",No,No,No,No,24,208.98000000000002
+285,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Inactive,No,HeLa,4.390520000000003,,Shimrit Azulay,,0.03 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,15,5,45 nM,82 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCCOCCOCCNC=O,PEG,13,5,10,907.0669999999999,No,,5WUK,73K,31831267,UNC6845,No,,Reviewed,"O75530, Q15022, Q15910",No,No,No,No,24,227.44
+286,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Inactive,No,HeLa,4.017020000000005,,Shimrit Azulay,,0.04 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,16,5,45 nM,613 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCOCCOCCOCCNC=O,PEG,15,6,12,937.0929999999998,No,,5WUK,73K,31831267,UNC6846,No,,Reviewed,"O75530, Q15022, Q15910",No,No,No,No,24,236.67000000000002
+287,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCNC(=O)c2ccc(-c3cnc(NCc4ccco4)n4cnnc34)cc2)C(C)(C)C)cc1,Inactive,No,HeLa,4.4237200000000065,,Shimrit Azulay,,29 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,5,45 nM,241 nM,EED226,CS(=O)(=O)c1ccc(-c2cnc(NCc3ccco3)n3cnnc23)cc1,O=CCCOCCOCCOCCOCCNC=O,PEG,19,7,16,995.1729999999997,No,,5WUK,73K,31831267,UNC6847,No,,Reviewed,"O75530, Q15022, Q15910",No,No,No,No,24,245.89999999999998
+288,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCNC(=O)c4ccc(CN(CC5CCCCC5)S(=O)(=O)c5ccc(S(=O)(=O)N(Cc6ccc(Cl)cc6)C6CCCC6)cc5)cc4)c3C2=O)C(=O)N1,Active,No,Jurkat,6.521000000000007,"proteomics of PDEdelta degradation show upregulation of enzymes involved in lipid metabolism - deltasonamide 1 also causes this. IC50 Deltasonamide 1 is 203 pM, and of the Bn derivative is 8 nM.",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,carboxilic_acid_to_amide,12,3,8 nM,14.8 nM,deltasonamide 1 Bn derivative,O=C(O)c1ccc(CN(CC2CCCCC2)S(=O)(=O)c2ccc(S(=O)(=O)N(Cc3ccc(Cl)cc3)C3CCCC3)cc2)cc1,NCCOCCOCCN,PEG,10,4,7,1045.678,ferritin light chain,,5ML8,V98,31829492,1,Yes,,Reviewed,O43924,No,No,No,No,"24,48",217.89999999999998
+289,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCNC(=O)c4ccc(CN(CC5CCCCC5)S(=O)(=O)c5ccc(S(=O)(=O)N(Cc6ccc(Cl)cc6)C6CCCC6)cc5)cc4)c3C2=O)C(=O)N1,Active,No,Jurkat,6.537600000000007,"proteomics of PDEdelta degradation show upregulation of enzymes involved in lipid metabolism - deltasonamide 1 also causes this. IC50 Deltasonamide 1 is 203 pM, and of the Bn derivative is 8 nM.",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,carboxilic_acid_to_amide,13,3,8 nM,27.0 nM,deltasonamide 1 Bn derivative,O=C(O)c1ccc(CN(CC2CCCCC2)S(=O)(=O)c2ccc(S(=O)(=O)N(Cc3ccc(Cl)cc3)C3CCCC3)cc2)cc1,NCCOCCOCCOCCN,PEG,13,5,10,1089.731,ferritin light chain,,5ML8,V98,31829492,2,Yes,,Reviewed,O43924,No,No,No,No,"24,48",227.13
+290,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCNC(=O)c4ccc(CN(CC5CCCCC5)S(=O)(=O)c5ccc(S(=O)(=O)N(Cc6ccc(Cl)cc6)C6CCCC6)cc5)cc4)c3C2=O)C(=O)N1,Active,Yes,Jurkat and Panc Tu‐I,6.554200000000007,"proteomics of PDEdelta degradation show upregulation of enzymes involved in lipid metabolism - deltasonamide 1 also causes this. Dmax was measured in Panc-Tu-1 cell line. DC50 is 83.4% (24 h, Panc-Tu-1), 85% (24 h, 1 uM, Jurkat). IC50 Deltasonamide 1 is 203 pM, and of the Bn derivative is 8 nM.",Paul Gehrtz,48 nM,> 83.4 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,carboxilic_acid_to_amide,14,3,8 nM,64.3 nM,deltasonamide 1 Bn derivative,O=C(O)c1ccc(CN(CC2CCCCC2)S(=O)(=O)c2ccc(S(=O)(=O)N(Cc3ccc(Cl)cc3)C3CCCC3)cc2)cc1,NCCOCCOCCOCCOCCN,PEG,16,6,13,1133.7839999999997,ferritin light chain,,5ML8,V98,31829492,3,Yes,,Reviewed,O43924,Yes,No,No,Yes,"24,48",236.35999999999999
+291,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](NC(=O)COCCOCCOCCOCCNC(=O)c2ccc(CN(CC3CCCCC3)S(=O)(=O)c3ccc(S(=O)(=O)N(Cc4ccc(Cl)cc4)C4CCCC4)cc3)cc2)C(C)C)cc1,Active,No,Jurkat and Panc Tu‐I,7.891820000000014,"proteomics of PDEdelta degradation show upregulation of enzymes involved in lipid metabolism - deltasonamide 1 also causes this. IC50 Deltasonamide 1 is 203 pM, and of the Bn derivative is 8 nM.",Paul Gehrtz,,,CC(=O)N[C@@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)C,VHL,,,carboxilic_acid_to_amide,15,4,8 nM,57.1 nM,deltasonamide 1 Bn derivative,O=C(O)c1ccc(CN(CC2CCCCC2)S(=O)(=O)c2ccc(S(=O)(=O)N(Cc3ccc(Cl)cc3)C3CCCC3)cc2)cc1,NCCOCCOCCOCCO,PEG,13,5,10,1291.0659999999996,ferritin light chain,,5ML8,V98,31829492,5,Yes,,Reviewed,O43924,No,No,No,No,"24,48",252.40999999999997
+292,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,9.255720000000004,,Adi Rogel,7.2 nM,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,aryl_C,12,3,8 nM,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1095.8079999999995,No,,,,31804827,1 (ARD-61),No,,Reviewed,P10275,No,No,No,No,"0.5,1,3,6,12,24",194.22999999999996
+293,C#Cc1ccc([C@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](c2cc(C)no2)C(C)C)cc1,Active,No,LNCaP,7.80510000000001,,Adi Rogel,,> 99 %,C#Cc1ccc([C@H](CC(=O)NC)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](c2cc(C)no2)C(C)C)cc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1022.6879999999995,No,,,,31804827,2,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+294,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(C#N)cc2)C(C)C)on1,Active,No,LNCaP,7.69548000000001,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(C#N)cc1,VHL,,,aryl_C,11,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1023.6759999999996,No,,,,31804827,3,No,,Reviewed,P10275,No,No,No,No,6,205.12999999999994
+295,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(Br)cc2)C(C)C)on1,Active,No,LNCaP,8.586300000000007,,Adi Rogel,,> 95 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Br)cc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1077.5619999999997,No,,,,31804827,4,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+296,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(Cl)cc2)C(C)C)on1,Active,No,LNCaP,8.477200000000007,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Cl)cc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1033.1109999999996,No,,,,31804827,5,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+297,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(F)cc2)C(C)C)on1,Active,No,LNCaP,7.96290000000001,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(F)cc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,1016.6559999999997,No,,,,31804827,6,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+298,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.82380000000001,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,998.6659999999997,No,,,,31804827,7,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+299,CC(=O)NC[C@H](C(=O)N1C[C@@H](O)C[C@@H]1C(=O)N[C@@H](CC(=O)N1CCC(N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)CC1)c1ccccc1)C(C)C,Inactive,No,LNCaP,6.4958800000000085,,Adi Rogel,,11 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](CNC(C)=O)C(C)C)c1ccccc1,VHL,,,aryl_C,9,4,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C(C)C)CC1,Other,11,1,1,988.6709999999997,No,,,,31804827,8,No,,Reviewed,P10275,No,No,No,No,6,184.40999999999997
+300,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)C3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.0436000000000085,,Adi Rogel,,86 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CN(C(C)C)C1,Other,9,1,1,970.6119999999997,No,,,,31804827,9,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+301,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)C2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.0436000000000085,,Adi Rogel,,68 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC1CCN(C)CC1,Other,9,1,0,970.6119999999997,No,,,,31804827,10,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+302,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccccc2)C(C)C)on1,Active,Yes,LNCaP,7.359400000000009,,Adi Rogel,0.5352 nM,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,915.5319999999999,No,,,,31804827,11 (ARD-266),No,,Reviewed,P10275,No,Yes,No,Yes,"0.5,1,3,6,12,24",178.09999999999997
+303,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C3CN(c4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)C3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.444100000000009,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_N,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,CC(C)C1CNC1,Other,7,1,1,946.5899999999998,No,,,,31804827,12,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+304,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CC(c4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)C3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.159500000000008,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,CC(C)N1CCC1,Other,7,1,1,946.5899999999998,No,,,,31804827,13,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+305,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(c3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,7.475300000000009,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,CCC,Other,3,0,0,891.5099999999999,No,,,,31804827,14,No,,Reviewed,P10275,No,No,No,No,6,178.09999999999997
+306,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCN(c3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccccc2)C(C)C)on1,Active,No,LNCaP,6.4179000000000075,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccccc1,VHL,,,aryl_N,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,CNC,Other,3,1,0,892.4979999999998,No,,,,31804827,15,No,,Reviewed,P10275,No,No,No,No,6,181.33999999999997
+307,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,8.791320000000006,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,aryl_C,11,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,1012.6739999999998,No,,,,31804827,16,No,,Reviewed,P10275,No,No,No,No,6,190.98999999999995
+308,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(F)cc2)C(C)C)on1,Active,No,LNCaP,7.49850000000001,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(F)cc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,933.5219999999999,No,,,,31804827,17,No,,Reviewed,P10275,No,No,No,No,6,178.09999999999997
+309,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(Cl)cc2)C(C)C)on1,Active,No,LNCaP,8.01280000000001,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Cl)cc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,949.9769999999999,No,,,,31804827,18,No,,Reviewed,P10275,No,No,No,No,6,178.09999999999997
+310,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(Br)cc2)C(C)C)on1,Active,No,LNCaP,8.121900000000009,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(Br)cc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,994.4279999999999,No,,,,31804827,19,No,,Reviewed,P10275,No,No,No,No,6,178.09999999999997
+311,Cc1cc([C@H](C(=O)N2C[C@@H](O)C[C@@H]2C(=O)N[C@@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)c2ccc(C#N)cc2)C(C)C)on1,Active,No,LNCaP,7.231080000000009,,Adi Rogel,,> 99 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(C#N)cc1,VHL,,,aryl_C,10,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,940.5419999999998,No,,,,31804827,20,No,,Reviewed,P10275,No,No,No,No,6,201.89
+312,C#Cc1ccc([C@H](CC(=O)N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](c2cc(C)no2)C(C)C)cc1,Active,No,LNCaP,7.340700000000009,,Adi Rogel,,> 99 %,C#Cc1ccc([C@H](CC(=O)NC)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](c2cc(C)no2)C(C)C)cc1,VHL,,,aryl_C,9,3,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,939.5539999999997,No,,,,31804827,21,No,,Reviewed,P10275,No,No,No,No,6,178.09999999999997
+313,CC(=O)N[C@H](C(=O)N1C[C@@H](O)C[C@@H]1C(=O)N[C@@H](CC(=O)N1CCC(C#Cc2ccc(C(=O)N[C@H]3C(C)(C)[C@H](Oc4ccc(C#N)c(Cl)c4)C3(C)C)cc2)CC1)c1ccccc1)C(C)C,Inactive,No,LNCaP,5.783880000000007,,Adi Rogel,,< 5 %,CNC(=O)C[C@H](NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@@H](CNC(C)=O)C(C)C)c1ccccc1,VHL,,,aryl_C,8,4,,,Apalutamide analog,CC1(C)[C@H](NC(=O)c2ccccc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,C#CC(C)C,Other,5,0,0,891.5099999999999,No,,,,31804827,22,No,,Reviewed,P10275,No,No,No,No,6,181.17
+314,CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF7,7.7630200000000125,also tested degradation for two common mutants of ERa. EC50 of PROTAC was measured in MCF-7 cell line.,Adi Rogel,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,15,5,,,RALOXIFENE,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,O=CCOCCOCCO,PEG,10,4,7,1050.31,No,,2JFA,RAL,32067153,ERD56,No,30990042,Reviewed,P03372,No,No,No,No,24,209.31999999999996
+315,CC/C(=C(\c1ccccc1)c1ccc(OCCN(CC)CCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)cc1)c1ccccc1,Active,No,MCF7,10.118819999999998,also tested degradation for two common mutants of ERa. EC50 of PROTAC was measured in MCF-7 cell line.,Adi Rogel,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,8,3,,,GW5638,CC/C(=C(\c1ccccc1)c1ccc(/C=C/C(=O)O)cc1)c1ccccc1,CCN(CCO)CCCCCC=O,Alkane,13,3,9,912.254,No,,1R5K,GW5,32067153,ERD32,No,30990042,Reviewed,P03372,No,No,No,No,24,124.10000000000001
+316,CCCCN(Cc1ccc(C(=O)NO)cc1)C(=O)Nc1ccc(NC(=O)CCCc2cn(CCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)cc1,Active,Yes,"HeLa, Mino, Jeko-1, HUVEC, MDA-MB-231, MM.1S",3.7226000000000026,,"Daniel Zaidman, Yangwode Jing",3.2 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_N,13,6,,,Nex A,CCCCN(Cc1ccc(C(=O)NO)cc1)C(=O)Nc1ccccc1,CCOCCn1cc(CCCC(N)=O)nn1,non-PEG polyether,16,6,8,836.907,No,,5G0J,N4R,31769449,NH2,No,30796636,Reviewed,Q9UBN7,Yes,Yes,No,Yes,"1,18,24",246.28999999999996
+317,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCn4cc(CCCCN(Cc5ccc(C(=O)NO)cc5)C(=O)Nc5ccccc5)nn4)c3C2=O)C(=O)N1,Active,No,"Hela, MM.1S",3.0006000000000004,,"Daniel Zaidman, Yangwode Jing",3.8 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,5,,,Nex A,CCCCN(Cc1ccc(C(=O)NO)cc1)C(=O)Nc1ccccc1,CCOCCOCCn1ccnn1,non-PEG polyether,13,5,7,795.8540000000004,No,,5G0J,N4R,31769449,NP8,No,30796636,Reviewed,Q9UBN7,Yes,Yes,No,Yes,"2,24",226.42
+318,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNc1cccc3nnn(C4CCC(=O)NC4=O)c(=O)c13)c1nnc(C)n1-2,Active,No,22Rv1,3.533760000000002,,Daniel Zaidman,,36 %,Nc1cccc2nnn(C3CCC(=O)NC3=O)c(=O)c12,Cereblon,,,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCOCCOCCN,Alkane,9,3,6,787.3029999999998,No,,,,30684871,TD-230,No,,Reviewed,O60885,No,No,No,No,24,196.60999999999996
+319,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCCCCNc1cccc3nnn(C4CCC(=O)NC4=O)c(=O)c13)c1nnc(C)n1-2,Active,No,22Rv1,5.841160000000005,,Daniel Zaidman,,63 %,Nc1cccc2nnn(C3CCC(=O)NC3=O)c(=O)c12,Cereblon,,,ester_to_amide,13,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCCCCCCCN,PEG,9,1,6,783.3589999999999,No,,,,30684871,TD-207,No,,Reviewed,O60885,No,No,No,No,24,178.14999999999998
+320,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(OCCOCCOCCNc3cccc4nnn(C5CCC(=O)NC5=O)c(=O)c34)cc1)c1nnc(C)n1-2,Active,No,22Rv1,5.435060000000005,,Daniel Zaidman,3.3 nM,100 %,Nc1cccc2nnn(C3CCC(=O)NC3=O)c(=O)c12,Cereblon,,,ester_to_amide,16,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCOCCOCCOc1ccc(N)cc1,PEG,16,4,8,879.3999999999999,No,,,,30684871,TD-188,No,,Reviewed,O60885,No,No,No,No,24,205.83999999999997
+321,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1cccc(OCCOCCOCCNc3cccc4nnn(C5CCC(=O)NC5=O)c(=O)c34)c1)c1nnc(C)n1-2,Active,Yes,22Rv1,5.435060000000005,,Daniel Zaidman,0.32 nM,100 %,Nc1cccc2nnn(C3CCC(=O)NC3=O)c(=O)c12,Cereblon,,,ester_to_amide,16,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCOCCOCCOc1cccc(N)c1,PEG,16,4,8,879.3999999999997,No,,,,30684871,TD-428,No,,Reviewed,O60885,No,Yes,No,Yes,24,205.83999999999997
+322,COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCC(=O)Nc3ccc(OCC(C)(O)C(=O)Nc4ccc([N+](=O)[O-])c(C(F)(F)F)c4)cc3)C(=O)C2)c(OC(C)C)c1,Active,Yes,HeLa,8.098400000000012,,Daniel Zaidman,,,COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,aliphatic_CO,15,4,4 nM,,SARM,CC(=O)Nc1ccc(OCC(C)(O)C(=O)Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)cc1,CC(=O)NCCOCCOCCO,PEG,13,5,8,1210.0569999999996,No,,,,18752944,SARM-nutlin PROTAC,No,,Reviewed,P10275,No,No,No,Yes,7,262.27
+323,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@@H](F)[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,Yes,"HeLa, MV4;11, A549",5.544680000000006,DC50 is 1-3nM,Daniel Zaidman,< 3 nM,100 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@@H](F)[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,15,4,,249 nM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCOCC=O,PEG,13,5,10,1020.6509999999995,"BRD2, BRD3",,,,29949369,15a,No,,Reviewed,O60885,No,No,No,No,24,211.48999999999995
+324,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@H](F)[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,No,"HeLa, MV4;11, A549",5.544680000000006,DC50 is 10-30nM,Daniel Zaidman,< 30 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@H](F)[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,15,4,,603 nM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCOCC=O,PEG,13,5,10,1020.6509999999995,"BRD2, BRD3",,,,29949369,15b,No,,Reviewed,O60885,No,No,No,No,24,211.48999999999995
+325,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCOCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,AML cells,2.3575200000000027,,Daniel Zaidman,,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCCNC(C)=O,PEG,15,5,10,936.0399999999996,"CDK4, IKZF1, IKZF3",,5L2I,LQQ,30595531,YKL-06-102,Yes,,Reviewed,"P11802, Q00534",No,Yes,No,Yes,4,248.62
+326,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCOCCNC(=O)COc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,Yes,"AML cells, CRBN-/-",2.3244200000000035,,Daniel Zaidman,,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,3,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCCNC(=O)CO,PEG,16,6,11,937.0239999999997,No,,5L2I,LQQ,30595531,BSJ-03-123,Yes,,Reviewed,Q00534,Yes,Yes,Yes,No,4,245.82
+327,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(CC(=O)NCCOCCOCCOCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,No,SU-DHL-1 and NCI-H2228,5.786820000000006,"competition with ligand only slightly rescued protein degradation. EC50 of ligand and PROTAC is measured on SUDHL-1 cell line. DC50 is SU-DHL-1: 3 ± 1 nM, NCI-H2228: 34 ± 9 nM.","Ella Livnah, Yangwode Jing",< 34 nM,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,19,5,1.3 nM,37 nM,Ceritinib,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1,CCOCCOCCOCCOCCOCCNC(C)=O,PEG,21,7,16,1134.7509999999993,No,,4MKC,4MK,29627725,5,No,,Reviewed,Q9UM73,Yes,Yes,No,Yes,16,267.28
+328,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(CC(=O)NCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1,Active,Yes,SU-DHL-1 and NCI-H2228,5.703820000000005,"competition with ligand only slightly rescued protein degradation. EC50 of ligand and PROTAC is measured on SUDHL-1 cell line. DC50 is SU-DHL-1: 11 ± 2 nM, NCI-H2228: 59 ± 16 nM.","Ella Livnah, Yangwode Jing",< 59 nM,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,14,5,1.3 nM,19 nM,Ceritinib,Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1,CCNC(C)=O,Alkane,6,2,1,914.4859999999995,No,,4MKC,4MK,29627725,6,No,,Reviewed,Q9UM73,Yes,Yes,No,Yes,16,221.13
+329,O=C(CCCCCCC(=O)N/N=C/c1ccc(OCCn2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)cc1)NO,Active,No,MCF-7,1.6665000000000023,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,5,,,compound 2c,COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1,Cc1cn(C)nn1,PEG,7,3,0,687.7140000000004,No,,,,29871848,9a,No,,Reviewed,Q9UBN7,No,Yes,No,No,12,226.30999999999995
+330,O=C(CCCCCCC(=O)N/N=C/c1ccc(OCCOCCn2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)cc1)NO,Active,No,MCF-7,1.6831000000000025,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,5,,,compound 2c,COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1,COCCn1cc(C)nn1,PEG,10,4,3,731.7670000000003,No,,,,29871848,9b,No,,Reviewed,Q9UBN7,No,Yes,No,No,12,235.53999999999996
+331,O=C(CCCCCCC(=O)N/N=C/c1ccc(OCCOCCOCCn2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)cc1)NO,Active,Yes,"MCF-7, MM.1S",1.6997000000000018,DC50 and Dmax are for MCF-7 cells,Barr Tivon,34 nM,70.5 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,5,,,compound 2c,COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1,COCCOCCn1cc(C)nn1,PEG,13,5,6,775.8200000000003,No,,,,29871848,dHDAC6 (or 9c),No,,Reviewed,Q9UBN7,No,Yes,No,Yes,12,244.76999999999998
+332,O=C(CCCCCCC(=O)N/N=C/c1ccc(OCCOCCOCCOCCn2cc(CNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)cc1)NO,Active,No,MCF-7,1.716300000000003,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,5,,,compound 2c,COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1,COCCOCCOCCn1cc(C)nn1,PEG,16,6,9,819.8730000000003,No,,,,29871848,9d,No,,Reviewed,Q9UBN7,No,Yes,No,No,12,254.0
+333,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCn1cc(COc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn1)c1nnc(C)n1-2,Active,No,H661,3.577760000000003,,Ella Livnah,0.49 uM,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,14,2,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(CO)nn1,PEG,10,5,3,781.2549999999998,No,,,,28378579,11a,No,,Reviewed,O60885,No,No,Yes,No,4,195.65999999999997
+334,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCn1cc(COCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn1)c1nnc(C)n1-2,Inactive,No,H661,3.5943600000000018,,Ella Livnah,> 5 uM,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,15,2,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCO)nn1,PEG,13,6,6,825.3079999999998,No,,,,28378579,11b,No,,Reviewed,O60885,No,No,Yes,No,4,204.89
+335,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCn1cc(COCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn1)c1nnc(C)n1-2,Inactive,No,H661,3.6109600000000013,,Ella Livnah,> 5 uM,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,16,2,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCO)nn1,PEG,16,7,9,869.3609999999999,No,,,,28378579,11c,No,,Reviewed,O60885,No,No,Yes,No,4,214.11999999999995
+336,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCn1cc(COCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn1)c1nnc(C)n1-2,Active,No,H661,3.6275600000000017,,Ella Livnah,0.45 uM,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,17,2,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCOCCO)nn1,PEG,19,8,12,913.4139999999998,No,,,,28378579,11d,No,,Reviewed,O60885,No,No,Yes,No,4,223.34999999999997
+337,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCn1cc(COCCOCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn1)c1nnc(C)n1-2,Active,Yes,H661,3.644160000000003,,Ella Livnah,0.20 uM,> 90 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,ester_to_amide,18,2,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCOCCOCCO)nn1,PEG,22,9,15,957.4669999999996,No,,,,28378579,11e,No,,Reviewed,O60885,No,Yes,Yes,Yes,4,232.57999999999998
+338,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCc2cn(CCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)nn2)C(C)(C)C)cc1,Active,No,H661,5.355180000000006,,Ella Livnah,0.059 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,16,4,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCC=O)nn1,PEG,13,6,6,995.6329999999995,No,,,,28378579,12a,No,,Reviewed,O60885,No,Yes,Yes,Yes,4,223.73999999999995
+339,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCc2cn(CCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)nn2)C(C)(C)C)cc1,Active,No,H661,5.371780000000006,,Ella Livnah,0.083 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,17,4,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCC=O)nn1,PEG,16,7,9,1039.6859999999995,No,,,,28378579,12b,No,,Reviewed,O60885,No,No,Yes,No,4,232.96999999999997
+340,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCc2cn(CCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)nn2)C(C)(C)C)cc1,Active,No,H661,5.388380000000007,,Ella Livnah,0.24 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,18,4,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCOCC=O)nn1,PEG,19,8,12,1083.7389999999991,No,,,,28378579,12c,No,,Reviewed,O60885,No,No,Yes,No,4,242.19999999999993
+341,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCc2cn(CCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)nn2)C(C)(C)C)cc1,Active,No,H661,5.404980000000009,,Ella Livnah,0.46 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,19,4,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCOCCOCC=O)nn1,PEG,22,9,15,1127.791999999999,No,,,,28378579,12d,No,,Reviewed,O60885,No,No,Yes,No,4,251.42999999999995
+342,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCc2cn(CCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)nn2)C(C)(C)C)cc1,Active,No,H661,5.421580000000009,,Ella Livnah,0.63 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,20,4,,,JQ-1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCn1cc(COCCOCCOCCOCCOCC=O)nn1,PEG,25,10,18,1171.8449999999991,No,,,,28378579,12e,No,,Reviewed,O60885,No,No,Yes,No,4,260.6599999999999
+343,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4cn(CCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,No,DU145/Cy,4.3777000000000035,"Tested reversal of docetaxel resistance by degradation of CYP, followed by lysis and WB, model with the ligand is available in previous publication",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,13,1,1.4 nM,101.2 nM,Compound 2,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3)oc12,OCCn1ccnn1,Other,8,4,2,729.7020000000001,No,,,,31945665,6A,No,,Reviewed,Q16678,No,No,No,No,48,181.39
+344,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4cn(CCCCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,No,DU145/Cy,5.548000000000006,"Tested reversal of docetaxel resistance by degradation of CYP, followed by lysis and WB, model with the ligand is available in previous publication",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,13,1,1.4 nM,152.7 nM,Compound 2,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3)oc12,OCCCCCn1ccnn1,Other,11,4,5,771.7830000000001,No,,,,31945665,6B,No,,Reviewed,Q16678,No,No,No,No,48,181.39
+345,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4cn(CCCCCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,Yes,DU145/Cy,5.938100000000007,"Tested reversal of docetaxel resistance by degradation of CYP, followed by lysis and WB, model with the ligand is available in previous publication",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,13,1,1.4 nM,95.1 nM,Compound 2,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3)oc12,OCCCCCCn1ccnn1,Other,12,4,6,785.8100000000001,No,,,,31945665,6C,No,,Reviewed,Q16678,No,No,No,No,48,181.39
+346,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccc(-c4cn(CCCCCCCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Inactive,No,DU145/Cy,6.718300000000006,"Tested reversal of docetaxel resistance by degradation of CYP, followed by lysis and WB, model with the ligand is available in previous publication",Paul Gehrtz,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,13,1,1.4 nM,166.2 nM,Compound 2,COc1ccc(OC)c2c1c(OC)cc1c(=O)cc(-c3ccccc3)oc12,OCCCCCCCCn1ccnn1,Other,14,4,8,813.8640000000001,No,,,,31945665,6D,No,,Reviewed,Q16678,No,No,No,No,48,181.39
+347,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,No,Hela,5.596680000000006,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,15,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCOCC=O,PEG,13,5,10,1002.6609999999996,"BRD2, BRD3",,3MXF,JQ1,28288108,MZ1,No,,Reviewed,O60885,Yes,No,Yes,No,24,211.48999999999995
+348,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,No,Hela,5.613280000000007,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,16,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1046.7139999999995,"BRD2, BRD3",,3MXF,JQ1,28288108,MZ2,No,,Reviewed,O60885,No,No,Yes,No,24,220.71999999999997
+349,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,No,Hela,6.324180000000008,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,16,5,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCOCC(=O)N[C@@H](C=O)Cc1ccccc1,PEG,24,7,14,1149.8379999999988,"BRD2, BRD3",,3MXF,JQ1,28288108,MZ3,No,,Reviewed,O60885,No,No,Yes,No,24,240.58999999999992
+350,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1,Active,No,Hela,5.580080000000006,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,14,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCC=O,PEG,10,4,7,958.6079999999996,"BRD2, BRD3",,3MXF,JQ1,28288108,MZ4,No,,Reviewed,O60885,No,No,Yes,No,24,202.26
+351,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,Yes,Hela,7.592880000000009,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,13,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCCCCS,Alkane,8,1,5,972.7039999999993,"BRD2, BRD3",,3MXF,JQ1,28288108,AT1,No,,Reviewed,O60885,No,No,Yes,No,24,183.8
+352,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,No,Hela,6.812680000000008,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,13,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCCS,Alkane,6,1,3,944.6499999999994,"BRD2, BRD3",,3MXF,JQ1,28288108,AT2,No,,Reviewed,O60885,No,No,Yes,No,24,183.8
+353,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCOCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,No,Hela,6.049080000000007,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,14,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCS,PEG,7,2,4,960.6489999999994,"BRD2, BRD3",,3MXF,JQ1,28288108,AT3,No,,Reviewed,O60885,No,No,Yes,No,24,193.02999999999997
+354,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCOCCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,No,Hela,6.829280000000009,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,14,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCOCCCS,non-PEG polyether,9,2,6,988.7029999999993,"BRD2, BRD3",,3MXF,JQ1,28288108,AT4,No,,Reviewed,O60885,No,No,Yes,No,24,193.02999999999997
+355,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCOCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,No,Hela,6.829280000000009,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,14,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCCCS,non-PEG polyether,9,2,6,988.7029999999993,"BRD2, BRD3",,3MXF,JQ1,28288108,AT5,No,,Reviewed,O60885,No,No,Yes,No,24,193.02999999999997
+356,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCOCCOCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21,Active,No,Hela,6.065680000000007,,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,15,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCOCCOCCS,PEG,10,3,7,1004.7019999999993,"BRD2, BRD3",,3MXF,JQ1,28288108,AT6,No,,Reviewed,O60885,No,No,Yes,No,24,202.26
+357,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOc2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2)C(C)(C)C)cc1,Active,No,VCaP,6.163400000000006,,Daniel Zaidman,,47 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,3,70 nM,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,O=CCOCCOCCOCCO,PEG,13,5,10,1008.155,No,,,,30271980,2a,No,,Reviewed,P10275,No,No,No,No,20,195.89
+358,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCCCCOc2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2)C(C)(C)C)cc1,Active,No,VCaP,7.707200000000009,,Daniel Zaidman,15 nM,76 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,70 nM,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,O=CCOCCCOCCCCCO,non-PEG polyether,14,4,11,1020.2099999999999,No,,,,30271980,2b,No,,Reviewed,P10275,No,No,No,No,20,186.66
+359,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCOc2ccc(-c3ccc(N4C(=S)N(c5ccc(C#N)c(C(F)(F)F)c5)C(=O)C4(C)C)cc3)cc2)C(C)(C)C)cc1,Active,Yes,VCaP,8.577400000000006,,Daniel Zaidman,5 nM,98 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,11,3,70 nM,36 nM,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,cc-c(cc)OCCCCOCC=O,Other,14,3,9,1024.2009999999998,No,,,,30271980,2c (ARCC-4),No,,Reviewed,P10275,Yes,No,No,Yes,20,177.43
+360,CN1CC(Nc2cnn(C)c(=O)c2Br)CC(c2ccc(C(=O)N(C)CCCN(C)c3ccc(CCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)cc2)C1,Active,No,THP1,4.453900000000003,DC50 is 1.5nM/3nM. DCmax is 97%/91%.,Daniel Zaidman,< 3 nM,> 91 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,12,2,60 nM,,GSK4027,CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1,CN(C=O)CCCN(C)c1ccc(CCCO)cc1,Other,19,4,9,895.8559999999998,No,,,,30200762,GSK983,No,,Reviewed,"Q92830, Q92831",No,No,No,No,18,166.48999999999998
+361,CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccc(C(=O)N(C)CCCN(C)c3ccc(CCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)cc2)C1,Active,Yes,THP1,4.453900000000003,,Daniel Zaidman,,97 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,12,2,60 nM,,GSK4027,CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1,CN(C=O)CCCN(C)c1ccc(CCCO)cc1,Other,19,4,9,895.8559999999998,No,,,,30200762,GSK699,No,,Reviewed,"Q92830, Q92831",No,No,No,Yes,18,166.48999999999998
+362,CN1C[C@@H](Nc2cnn(C)c(=O)c2Br)C[C@@H](c2ccc(C(=O)N(C)CCCN(C)c3ccc(CCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)cc2)C1,Active,No,THP1,4.453900000000003,only slightly active,Daniel Zaidman,,38 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,12,2,60 nM,,GSK4027,CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1,CN(C=O)CCCN(C)c1ccc(CCCO)cc1,Other,19,4,9,895.8559999999998,No,,,,30200762,GSK702,No,,Reviewed,"Q92830, Q92831",No,No,No,No,18,166.48999999999998
+363,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,No,PC3,5.883320000000005,,Daniel Zaidman,23.2 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,3.9 nM,10.7 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCOCCO,PEG,7,3,4,982.121,No,,,,30444612,PROTAC-1,No,,Reviewed,Q05397,No,No,No,No,24,217.31
+364,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,No,PC3,6.273420000000005,,Daniel Zaidman,7.6 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,3.9 nM,14.7 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCOCCCO,non-PEG polyether,8,3,5,996.1479999999999,No,,,,30444612,PROTAC-2,No,,Reviewed,Q05397,No,No,No,No,24,217.31
+365,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,Yes,"PC3, MDA-MB-231",6.273420000000005,,Daniel Zaidman,3.0 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,3.9 nM,6.5 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCCOCCO,PEG,8,3,5,996.1479999999999,Other kinases,,,,30444612,PROTAC-3,No,,Reviewed,Q05397,Yes,No,No,No,24,217.31
+366,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,No,PC3,6.663520000000006,,Daniel Zaidman,4.0 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,3.9 nM,14.5 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCCOCCCO,non-PEG polyether,9,3,6,1010.175,No,,,,30444612,PROTAC-4,No,,Reviewed,Q05397,No,No,No,No,24,217.31
+367,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,No,PC3,6.2900200000000055,,Daniel Zaidman,20.8 nM,99 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,15,5,3.9 nM,12.7 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCCOCCOCCO,PEG,11,4,8,1040.201,No,,,,30444612,PROTAC-5,No,,Reviewed,Q05397,No,No,No,No,24,226.54000000000002
+368,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1,Active,No,PC3,6.323220000000006,,Daniel Zaidman,48.1 nM,91 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,5,3.9 nM,6.1 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=CCCOCCOCCOCCOCCO,PEG,17,6,14,1128.3069999999996,No,,,,30444612,PROTAC-6,No,,Reviewed,Q05397,No,No,No,No,24,245.0
+369,CN(c1cccc(CNc2nc(Nc3ccc(OCCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O,Active,No,PC3,4.018900000000002,,Daniel Zaidman,8.2 nM,98 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,4,3.9 nM,11.3 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=C(CCOCCCO)NCCO,non-PEG polyether,13,5,8,896.9020000000003,No,,,,30444612,PROTAC-8,No,,Reviewed,Q05397,No,No,No,No,24,227.56
+370,CN(c1cccc(CNc2nc(Nc3ccc(OCCOCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O,Active,No,PC3,3.6454000000000013,,Daniel Zaidman,26.7 nM,99 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,4,3.9 nM,4.7 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=C(CCOCCOCCO)NCCO,PEG,15,6,10,926.9280000000002,No,,,,30444612,PROTAC-9,No,,Reviewed,Q05397,No,No,No,No,24,236.79000000000002
+371,CN(c1cccc(CNc2nc(Nc3ccc(OCCOCCOCCOCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O,Active,No,PC3,3.678600000000003,,Daniel Zaidman,< 10 nM,87 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,17,4,3.9 nM,9.7 nM,defactinib analog,CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3N(C)S(C)(=O)=O)n2)cc1,O=C(CCOCCOCCOCCOCCO)NCCO,PEG,21,8,16,1015.0340000000002,No,,,,30444612,PROTAC-10,No,,Reviewed,Q05397,No,No,No,No,24,255.25
+372,Cc1ncsc1-c1ccc2c(c1)OCCOCCOC[C@@H](NC(=O)C[C@@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COCCOCCOCC(=O)N[C@@H](C(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NC2,Active,Yes,hela,5.3908800000000054,they heva a ternary complex crystal structure but dont give PDB. DC50 is between 25-125nM,Efrat Resnick,< 125 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,ester_to_amide,18,4,,189 nM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,N[C@H](COCCOCCO)COCCOCCOCC=O,Other,21,8,17,1118.7769999999994,Brd2 and Brd3 (DC50 >125nM),,,,31746102,macroPROTAC-1,No,,Reviewed,O60885,No,No,No,No,"4,18",239.17999999999998
+373,Cc1nc(CCC(=O)NCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12,Active,No,Karpas422,5.640940000000007,,Adi Rogel,,~ 100 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,14,5,< 1 nM,< 1 nM,EED ligand,CNC(=O)CCc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)c(C)n1,CCCC=O,Alkane,5,1,2,960.1499999999994,"SUZ12, EZH2 (also members of the PRC2 complex)",,,,31786184,PROTAC 1,Yes,,Reviewed,O75530,Yes,Yes,No,Yes,"1,2,6,8,24,48",217.95999999999998
+374,Cc1nc(CCC(=O)NCCOc2ccc(OCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)cc2)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12,Active,Yes,Karpas422,5.928440000000008,,Adi Rogel,,~ 100 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,5,< 1 nM,~ 1 nM,EED ligand,CNC(=O)CCc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)c(C)n1,COc1ccc(OCC=O)cc1,Other,12,3,4,1054.2189999999996,"SUZ12, EZH2 (also members of the PRC2 complex)",,,,31786184,PROTAC 2,Yes,,Reviewed,O75530,Yes,Yes,No,Yes,"1,2,6,8,24,48",236.41999999999996
+375,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(OCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2,Active,Yes,"Namalwa, CA-46, Ramos",5.770260000000006,"tested also biological effects - proliferation and caspase activity on BL cells. IC50 of ligand is 14 nM (BD1), 3.5 nM (BD2). IC50 of PROTAC is 90 nM (BD1), 28 nM (BD2).",Adi Rogel,< 1 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,3,< 14 nM,< 90 nM,OTX015,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2,CCOCCOCCOCC,PEG,11,3,8,923.4489999999997,No,,,,26051217,ARV-825,No,,Reviewed,O60885,No,No,No,Yes,"0.5,1,2,4,7,24",204.67000000000002
+376,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)c2cn(CCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nn2)C1,Active,Yes,"HBL1, Ramos, Mino, IgE MM",3.4997000000000007,"also degrades ibrutinib-resistant C481S BTK. DC50 is 6.3 nM (HBL1), 8.5 nM (Ramos), 9.2 nM (Mino), 11.4 nM (IgE MM)",Adi Rogel,< 11.4 nM,94 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,3,,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,cn(CCOCCOCCOCC)nn,Other,15,6,10,912.9649999999997,No,,5P9J,"8E8",29875397,P13I,No,,Reviewed,Q06187,No,Yes,No,Yes,"4,8,12,24",253.14
+377,N#CC1=C(NCCC(=O)NCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,Inactive,No,hela,4.793680000000003,"IC50 error: for ligand ± 0.87 uM, for PROTAC ± 3.66 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,2.31 uM,10.48 uM,S1-6,N#CC1=C(C#N)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,CCNC(=O)CCN,Alkane,8,3,3,777.6570000000002,No,,,,31389699,H1,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,177.57
+378,N#CC1=C(NCCC(=O)NCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,Inactive,No,hela,5.573880000000004,"IC50 error: for ligand ± 0.87 uM, for PROTAC ± 2.13 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,2.31 uM,9.71 uM,S1-6,N#CC1=C(C#N)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,CCCCNC(=O)CCN,Alkane,10,3,5,805.7110000000001,No,,,,31389699,H2,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,177.57
+379,N#CC1=C(NCCC(=O)NCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,Inactive,No,hela,6.354080000000006,"IC50 error: for ligand ± 0.87 uM, for PROTAC ± 0.58 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,2.31 uM,1.94 uM,S1-6,N#CC1=C(C#N)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,CCCCCCNC(=O)CCN,Alkane,12,3,7,833.7650000000001,No,,,,31389699,H3,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,177.57
+380,N#CC1=C(NCCC(=O)NCCCCCC(=O)NCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,Inactive,No,hela,7.030680000000006,"IC50 error: for ligand ± 0.87 uM, for PROTAC ± 4.44 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,11,5,2.31 uM,11.65 uM,S1-6,N#CC1=C(C#N)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,CCCCCCNC(=O)CCCCCNC(=O)CCN,Other,20,5,13,946.9250000000002,No,,,,31389699,H4,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,206.67
+381,N#CC1=C(NCCC(=O)NCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,Inactive,No,hela,4.826880000000005,"IC50 error: for ligand ± 0.87 uM, for PROTAC ± 0.89 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,4,2.31 uM,2.24 uM,S1-6,N#CC1=C(C#N)c2ccc(Sc3ccc(Br)cc3)c3cccc(c23)C1=O,CCOCCOCCNC(=O)CCN,PEG,14,5,9,865.763,No,,,,31389699,H5,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,196.03
+382,O=C(CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O)NCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,hela,4.6556000000000015,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 4.33 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,3.18 uM,15.21 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCN,Alkane,3,1,0,853.7519999999997,No,,,,31389699,C1,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,191.16
+383,O=C(CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,hela,5.435800000000003,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 2.90 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,3.18 uM,10.02 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCCCN,Alkane,5,1,2,881.8059999999996,No,,,,31389699,C2,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,191.16
+384,O=C(CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,Yes,hela,6.216000000000005,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 0.27 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,3.18 uM,0.54 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCCCCCN,Alkane,7,1,4,909.8599999999994,No,,,,31389699,C3,No,,Reviewed,"Q07820, Q92934",Yes,Yes,Yes,Yes,12,191.16
+385,O=C(CCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCNC(=O)CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O,Inactive,No,hela,6.892600000000007,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 4.57 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,11,5,3.18 uM,13.47 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCCCCC(=O)NCCCCCCN,Other,15,3,10,1023.0199999999998,No,,,,31389699,C4,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,220.26
+386,O=C(CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O)NCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,Yes,hela,4.688800000000002,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 1.36 uM",Efrat Resnick,3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,4,3.18 uM,4.94 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCOCCOCCN,Other,9,3,6,941.8579999999995,No,,,,31389699,C5,No,,Reviewed,"Q07820, Q92934",Yes,Yes,Yes,Yes,12,209.62
+387,O=C(CCCCC(=O)NCCN1C(=O)c2cccc3c(Sc4ccc(Br)cc4)ccc(c23)C1=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Inactive,No,hela,6.996200000000006,"IC50 error: for ligand ± 1.39 uM, for PROTAC ± 2.28 uM",Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,4,3.18 uM,7.66 uM,Nap-1,CC(C)(C)c1ccc(C(=O)NCCN2C(=O)c3cccc4c(Sc5ccc(Br)cc5)ccc(c34)C2=O)cc1,CCCCCCCCN,Other,9,1,6,937.9139999999993,No,,,,31389699,C6,No,,Reviewed,"Q07820, Q92934",No,No,No,No,12,191.16
+388,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Inactive,No,"Ramos, THP-1",3.5885000000000007,Ligand name is from PMID 24068666,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,4,0.5 nM,735 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCO,PEG,3,1,0,756.7229999999998,No,,,,30012605,1,No,,Reviewed,Q06187,No,No,No,No,24,221.28000000000003
+389,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)COCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Inactive,No,"Ramos, THP-1",2.995099999999999,Ligand name is from PMID 24068666,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,4,0.5 nM,1400 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOC,PEG,4,1,1,770.7499999999999,No,,,,30012605,2,No,,Reviewed,Q06187,No,No,No,No,24,221.28000000000003
+390,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.605100000000001,Ligand name is from PMID 24068666. DCmax is 18-33%,Adi Rogel,,< 33 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,4,0.5 nM,1535 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCO,PEG,6,2,3,800.7759999999998,No,,,,30012605,3,No,,Reviewed,Q06187,No,No,No,No,24,230.51000000000002
+391,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)COCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.0116999999999994,Ligand name is from PMID 24068666. DCmax is 15-34%,Adi Rogel,,< 34 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,4,0.5 nM,489 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOC,PEG,7,2,4,814.8029999999999,No,,,,30012605,4,No,,Reviewed,Q06187,No,No,No,No,24,230.51000000000002
+392,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.6217000000000006,Ligand name is from PMID 24068666. DCmax is 36-64%. DC50 is 1487 - 1994.5 nM.,Adi Rogel,< 1994.5 nM,< 64 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,4,0.5 nM,1150 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCO,PEG,9,3,6,844.8289999999997,No,,,,30012605,5,No,,Reviewed,Q06187,No,No,No,No,24,239.74
+393,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.638300000000001,Ligand name is from PMID 24068666. DCmax is 68-85%. DC50 is 36.9 - 398.5 nM.,Adi Rogel,< 398.5 nM,> 68 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,0.5 nM,71 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCO,PEG,12,4,9,888.8819999999996,No,,,,30012605,6,No,,Reviewed,Q06187,No,No,No,No,24,248.97000000000003
+394,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)COCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.044900000000001,Ligand name is from PMID 24068666. DCmax is 63-84%. DC50 is 21.8 - 469.9 nM.,Adi Rogel,< 469.9 nM,> 63 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,0.5 nM,79 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOC,PEG,13,4,10,902.9089999999997,No,,,,30012605,7,No,,Reviewed,Q06187,No,No,No,No,24,248.97000000000003
+395,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.6549000000000014,Ligand name is from PMID 24068666. DCmax is 75-87%. DC50 is 4.5 - 90.5 nM.,Adi Rogel,< 90.5 nM,> 75 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,0.5 nM,80 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCO,PEG,15,5,12,932.9349999999995,No,,,,30012605,8,No,,Reviewed,Q06187,No,No,No,No,24,258.2
+396,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)COCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.0615000000000014,Ligand name is from PMID 24068666. DCmax is 71-85%. DC50 is 5.9 - 217.7 nM.,Adi Rogel,< 217.7 nM,> 71 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,0.5 nM,74 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCOC,PEG,16,5,13,946.9619999999995,"TEC, ZFP91, IKZF1, IKZF3, ZNF827",,,,30012605,9,Yes,,Reviewed,Q06187,No,Yes,No,No,"0.02,0.5,1,2,4,6,8,24,32,48",258.2
+397,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)OCCOCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,Yes,"Ramos, THP-1",3.6715000000000018,Ligand name is from PMID 24068666. DCmax is 80-87%. DC50 is 1.1 - 37.4 nM.,Adi Rogel,< 37.4 nM,> 80 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,0.5 nM,61 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCOCCO,PEG,18,6,15,976.9879999999994,"ZFP91, IKZF1, IKZF3, ZNF827",,,,30012605,10,Yes,,Reviewed,Q06187,No,No,No,No,24,267.43
+398,NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@H]2CCCN(C(=O)COCCOCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C2)c1N,Active,No,"Ramos, THP-1",3.078100000000002,Ligand name is from PMID 24068666. DCmax is 70-85%. DC50 is 9.7 - 184.1 nM.,Adi Rogel,< 184.1 nM,> 70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,0.5 nM,138 nM,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCOCCOC,PEG,19,6,16,991.0149999999994,No,,,,30012605,11,No,,Reviewed,Q06187,No,No,No,No,24,267.43
+399,Cc1nc[nH]c1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCC(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccc(F)cc5F)cc4)c(C(N)=O)c3N)C2)C(C)(C)C)cc1,Inactive,No,"Ramos, THP-1",4.836020000000009,Ligand name is from PMID 24068666,Adi Rogel,,,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2[nH]cnc2C)cc1)C(C)(C)C,VHL,,,other,16,6,,,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCOC,PEG,16,5,13,1129.2729999999992,No,,,,30012605,12,No,,Reviewed,Q06187,No,No,No,No,24,290.0399999999999
+400,Cc1nc[nH]c1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCC(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccc(F)cc5F)cc4)c(C(N)=O)c3N)C2)C(C)(C)C)cc1,Inactive,No,"Ramos, THP-1",4.8526200000000115,Ligand name is from PMID 24068666,Adi Rogel,,,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2[nH]cnc2C)cc1)C(C)(C)C,VHL,,,other,17,6,,,PF-06250112,N#CN1CCC[C@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1,CCOCCOCCOCCOCCOCCOC,PEG,19,6,16,1173.3259999999993,No,,,,30012605,13,No,,Reviewed,Q06187,No,No,No,No,24,299.2699999999999
+401,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,2.8121,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,16,3,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCC=O,PEG,9,3,6,871.8639999999998,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,3a,No,,Reviewed,Q06187,No,Yes,No,Yes,24,256.57
+402,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,2.8287000000000004,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,17,3,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCCOCC=O,PEG,12,4,9,915.9169999999997,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,3b,No,,Reviewed,Q06187,No,Yes,No,Yes,24,265.79999999999995
+403,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,2.845300000000001,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,18,3,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCCOCCOCC=O,PEG,15,5,12,959.9699999999996,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,3c,No,,Reviewed,Q06187,No,Yes,No,Yes,24,275.03
+404,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCCOCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,2.861900000000004,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,19,3,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCCOCCOCCOCC=O,PEG,18,6,15,1004.0229999999995,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,3d,No,,Reviewed,Q06187,No,Yes,No,Yes,24,284.25999999999993
+405,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,3.605500000000001,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCCCN,Alkane,5,1,2,796.845,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,4a,No,,Reviewed,Q06187,No,Yes,No,Yes,24,223.83999999999997
+406,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)NCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,4.385700000000002,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCCCCCN,Alkane,7,1,4,824.8989999999999,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,4b,No,,Reviewed,Q06187,No,Yes,No,Yes,24,223.83999999999997
+407,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,5.165900000000003,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCCCCCCCN,Alkane,9,1,6,852.9529999999997,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,4c,No,,Reviewed,Q06187,No,Yes,No,Yes,24,223.83999999999997
+408,C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)NCCCCCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Active,No,K562,6.7263000000000055,Covalent Protac,Paul Gehrtz,,~ 50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCCCCCCCCCCCN,Alkane,13,1,10,909.0609999999995,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,4d,No,,Reviewed,Q06187,No,Yes,No,Yes,24,223.83999999999997
+409,C=CC(=O)N[C@@H](CCC(=O)OCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Inactive,No,K562,4.347440000000008,Covalent Protac,Paul Gehrtz,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,16,7,,,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,CCOCCOCC=O,PEG,9,3,6,1037.0559999999998,BLK (proven for cmpd 7),,,,31922153,5a,No,,Reviewed,Q06187,No,Yes,No,Yes,24,311.61999999999995
+410,C=CC(=O)N[C@@H](CCC(=O)OCCOCCOCCOCCOCC(=O)Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Inactive,No,K562,4.38064000000001,Covalent Protac,Paul Gehrtz,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,18,7,,,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,CCOCCOCCOCCOCC=O,PEG,15,5,12,1125.1619999999998,BLK (proven for cmpd 7),,,,31922153,5b,No,,Reviewed,Q06187,No,Yes,No,Yes,24,330.0799999999999
+411,C=CC(=O)N[C@@H](CCC(=O)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Active,No,K562,5.140840000000003,Covalent Protac,Paul Gehrtz,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,8,,,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,CCCCN,Alkane,5,1,2,962.0369999999999,BLK (proven for cmpd 7),,,,31922153,6a,No,,Reviewed,Q06187,No,Yes,No,Yes,24,278.89
+412,C=CC(=O)N[C@@H](CCC(=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Active,No,K562,6.701240000000003,Covalent Protac,Paul Gehrtz,< 300 nM,~ 75 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,8,,186 nM,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,CCCCCCCCN,Alkane,9,1,6,1018.1449999999998,BLK (proven for cmpd 7),,,,31922153,6b,No,,Reviewed,Q06187,No,Yes,No,Yes,24,278.89
+413,C=CC(=O)N1C[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,Yes,K562,5.013220000000006,Covalent Protac,Paul Gehrtz,136 nM,88 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,carboxilic_acid_to_ester,17,4,,39 nM,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCC=O,PEG,9,3,6,1029.1899999999996,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,7,No,,Reviewed,Q06187,No,Yes,No,Yes,24,255.54999999999995
+414,C=CC(=O)N[C@H](CCC(=O)NCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)CC1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Active,No,K562,8.428960000000007,Covalent Protac,Paul Gehrtz,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,carboxilic_acid_to_amide,14,9,,,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,NCCCCCCCC=O,Alkane,10,2,7,1189.4539999999995,BLK (proven for cmpd 7),,,,31922153,8,No,,Reviewed,Q06187,No,Yes,No,Yes,24,294.93999999999994
+415,CCC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)OCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)CC1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,No,K562,5.237220000000007,Non covalent control,Paul Gehrtz,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,4,,2657 nM,1 (Ibrutinib analogue),C=CC(=O)N1C[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C[C@H]1C(=O)O,CCOCCOCC=O,PEG,9,3,6,1031.2059999999994,BLK (proven for cmpd 7),,5P9J,"8E8",31922153,9,No,,Reviewed,Q06187,No,Yes,No,Yes,24,255.54999999999995
+416,CCC(=O)N[C@@H](CCC(=O)NCCCCCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,Active,No,K562,6.925240000000003,Non covalent control,Paul Gehrtz,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,8,,415 nM,2 (PLS-123 analogue),C=CC(=O)N[C@@H](CCC(=O)O)C(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C)c4)ccc3C)cn2)c1,CCCCCCCCN,Alkane,9,1,6,1020.1609999999997,BLK (proven for cmpd 7),,,,31922153,10,No,,Reviewed,Q06187,No,Yes,No,Yes,24,278.89
+417,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,3.016420000000002,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,19,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCn1cc(C)nn1,Other,14,5,7,916.0129999999995,No,,2EUF,LQQ,31330105,CP-2,No,,Reviewed,Q00534,Yes,No,No,No,,240.99999999999994
+418,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,3.033020000000004,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,20,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCCn1cc(C)nn1,Other,17,6,10,960.0659999999995,No,,2EUF,LQQ,31330105,CP-3,No,,Reviewed,Q00534,No,No,No,No,,250.22999999999996
+419,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,3.0496200000000036,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,21,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCCOCCn1cc(C)nn1,Other,20,7,13,1004.1189999999996,No,,2EUF,LQQ,31330105,CP-4,No,,Reviewed,Q00534,No,No,No,No,,259.46
+420,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,2.324320000000002,DC50 for CDK4 > 100 nM,Efrat Resnick,1.1 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,16,4,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCNC(C)=O,Other,9,3,4,847.9339999999995,No,,2EUF,LQQ,31330105,CP-5,No,,Reviewed,Q00534,No,No,No,No,,230.15999999999997
+421,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,2.3409200000000014,DC50 for CDK4 > 100 nM,Efrat Resnick,24.2 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,4,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCNC(C)=O,Other,12,4,7,891.9869999999995,No,,2EUF,LQQ,31330105,CP-6,No,,Reviewed,Q00534,No,No,No,No,,239.39
+422,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCOCCOCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,2.374120000000006,DC50 for CDK4 > 100 nM,Efrat Resnick,31 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,19,4,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCCOCCNC(C)=O,Other,18,6,13,980.0929999999995,No,,2EUF,LQQ,31330105,CP-8,No,,Reviewed,Q00534,No,No,No,No,,257.85
+423,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,Yes,U251,2.9998200000000015,DC50 for CDK4 > 100 nM. EC50 of PROTAC is 10nM in MM.lS 8nM in Mino.,Efrat Resnick,2.1 nM,89 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCn1cc(C)nn1,Other,11,4,4,871.9599999999995,No,,2EUF,LQQ,31330105,CP-10,Yes,,Reviewed,Q00534,Yes,Yes,No,Yes,,231.76999999999998
+424,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,4.153520000000002,DC50 for CDK4 > 100 nM,Efrat Resnick,5.3 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCn1cc(C)nn1,Other,11,3,4,869.9879999999995,No,,2EUF,LQQ,31330105,CP-13,No,,Reviewed,Q00534,No,No,No,No,,222.53999999999996
+425,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,4.543620000000002,DC50 for CDK4 > 100 nM,Efrat Resnick,10.6 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCCn1cc(C)nn1,Other,12,3,5,884.0149999999995,No,,2EUF,LQQ,31330105,CP-14,No,,Reviewed,Q00534,No,No,No,No,,222.53999999999996
+426,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,3.2247200000000014,DC50 for CDK4 > 100 nM,Efrat Resnick,1.6 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,16,3,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCC,Other,8,2,5,834.9349999999996,No,,2EUF,LQQ,31330105,CP-15,No,,Reviewed,Q00534,No,No,No,No,,210.28999999999996
+427,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCCCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,5.0340200000000035,DC50 for CDK4 > 50 nM,Efrat Resnick,1.7 nM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,15,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCCn1cc(C)nn1,Other,12,3,5,855.0169999999996,No,,2EUF,LQQ,31330105,CP-16,No,,Reviewed,Q00534,No,No,No,No,,193.43999999999994
+428,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCCCC#Cc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,4.093120000000002,DC50 for CDK4 > 100 nM,Efrat Resnick,81.6 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,16,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,C#CCCCCn1cc(C)nn1,Other,12,3,4,864.9679999999995,No,,2EUF,LQQ,31330105,CP-21,No,,Reviewed,Q00534,No,No,No,No,,210.50999999999993
+429,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCCCCC#Cc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,,4.483220000000003,DC50 for CDK4 > 100 nM,Efrat Resnick,86.8 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,16,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,C#CCCCCCn1cc(C)nn1,Other,13,3,5,878.9949999999995,No,,2EUF,LQQ,31330105,CP-22,No,,Reviewed,Q00534,No,No,No,No,,210.50999999999993
+430,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCn3cc(CN4CCN(c5ccc(Nc6ncc7c(C)c(C(C)=O)c(=O)n(C8CCCC8)c7n6)nc5)CC4)nn3)C(=O)C2)c(OC(C)C)c1,Inactive,No,,8.214520000000011,,Efrat Resnick,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,amine_to_methylamine,19,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CC(=O)NCCOCCn1cc(C)nn1,Other,15,6,6,1237.263999999999,No,,2EUF,LQQ,31330105,MP-1,No,,Reviewed,Q00534,No,No,No,No,,239.96999999999994
+431,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCn3cc(CN4CCN(c5ccc(Nc6ncc7c(C)c(C(C)=O)c(=O)n(C8CCCC8)c7n6)nc5)CC4)nn3)C(=O)C2)c(OC(C)C)c1,Inactive,No,,8.23112000000001,,Efrat Resnick,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,amine_to_methylamine,20,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CC(=O)NCCOCCOCCn1cc(C)nn1,Other,18,7,9,1281.3169999999993,No,,2EUF,LQQ,31330105,MP-2,No,,Reviewed,Q00534,No,No,No,No,,249.1999999999999
+432,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCCn3cc(CN4CCN(c5ccc(Nc6ncc7c(C)c(C(C)=O)c(=O)n(C8CCCC8)c7n6)nc5)CC4)nn3)C(=O)C2)c(OC(C)C)c1,Inactive,No,,8.24772000000001,,Efrat Resnick,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,amine_to_methylamine,21,2,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CC(=O)NCCOCCOCCOCCn1cc(C)nn1,Other,21,8,12,1325.3699999999994,No,,2EUF,LQQ,31330105,MP-3,No,,Reviewed,Q00534,No,No,No,No,,258.42999999999995
+433,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCNC(=O)CCC(=O)NC(C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Inactive,No,,4.623940000000008,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,20,5,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,Cc1cn(CCOCCNC(=O)CCC=O)nn1,Other,18,7,9,1128.3749999999998,No,,2EUF,LQQ,31330105,VP-1,No,,Reviewed,Q00534,No,No,No,No,,276.91999999999996
+434,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCNC(=O)CCC(=O)NC(C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Inactive,No,,4.64054000000001,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,21,5,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,Cc1cn(CCOCCOCCNC(=O)CCC=O)nn1,Other,21,8,12,1172.4279999999999,No,,2EUF,LQQ,31330105,VP-2,No,,Reviewed,Q00534,No,No,No,No,,286.1499999999999
+435,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCOCCNC(=O)CCC(=O)NC(C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Inactive,No,,4.657140000000011,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,22,5,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,Cc1cn(CCOCCOCCOCCNC(=O)CCC=O)nn1,Other,24,9,15,1216.4810000000002,No,,2EUF,LQQ,31330105,VP-3,No,,Reviewed,Q00534,No,No,No,No,,295.37999999999994
+436,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCOCCOCCNC(=O)CCC(=O)NC(C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)nn5)CC4)cn3)nc2n(C2CCCC2)c1=O,Inactive,No,,4.673740000000012,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,23,5,,,palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,Cc1cn(CCOCCOCCOCCOCCNC(=O)CCC=O)nn1,Other,27,10,18,1260.5340000000003,No,,2EUF,LQQ,31330105,VP-4,No,,Reviewed,Q00534,No,No,No,No,,304.60999999999996
+437,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n1C1CCCC1,Inactive,No,,2.830400000000002,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,3,,,ribociclib,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1,CCOCCn1cc(C)nn1,Other,11,4,4,858.9649999999993,No,,5L2T,6ZZ,31330105,CP-R1,No,,Reviewed,Q00534,No,No,No,No,,217.93999999999994
+438,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n1C1CCCC1,Inactive,No,,2.8470000000000013,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,3,,,ribociclib,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1,CCOCCOCCn1cc(C)nn1,Other,14,5,7,903.0179999999993,No,,5L2T,6ZZ,31330105,CP-R2,No,,Reviewed,Q00534,No,No,No,No,,227.16999999999996
+439,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(Cc5cn(CCOCCOCCOCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nn5)CC4)cn3)nc2n1C1CCCC1,Inactive,No,,2.8636000000000026,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,19,3,,,ribociclib,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1,CCOCCOCCOCCn1cc(C)nn1,Other,17,6,10,947.0709999999995,No,,5L2T,6ZZ,31330105,CP-R3,No,,Reviewed,Q00534,No,No,No,No,,236.39999999999998
+440,Cc1nc2c(F)cc(-c3nc(Nc4ccc(CN5CCN(c6cn(CCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)cn4)ncc3F)cc2n1C(C)C,Active,No,,4.243020000000002,DC50 for CDK4 > 500 nM,Efrat Resnick,8.6 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,3,,,Abemaciclib,CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1,CCOCCnnn,Other,8,4,4,888.9409999999997,No,,5L2S,6ZZ,31330105,CP-A1,No,,Reviewed,Q00534,No,No,No,No,,210.51999999999998
+441,Cc1nc2c(F)cc(-c3nc(Nc4ccc(CN5CCN(c6cn(CCOCCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)cn4)ncc3F)cc2n1C(C)C,Active,No,,4.259620000000002,DC50 for CDK4 > 500 nM,Efrat Resnick,129.7 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,3,,,Abemaciclib,CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1,CCOCCOCCnnn,Other,11,5,7,932.9939999999997,No,,5L2S,6ZZ,31330105,CP-A2,No,,Reviewed,Q00534,No,No,No,No,,219.74999999999994
+442,Cc1nc2c(F)cc(-c3nc(Nc4ccc(CN5CCN(c6cn(CCOCCOCCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)cn4)ncc3F)cc2n1C(C)C,Active,No,,4.276220000000003,DC50 for CDK4 > 500 nM,Efrat Resnick,271.9 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,3,,,Abemaciclib,CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1,CCOCCOCCOCCnnn,Other,14,6,10,977.0469999999998,No,,5L2S,6ZZ,31330105,CP-A3,No,,Reviewed,Q00534,No,No,No,No,,228.97999999999996
+443,Cc1nc2c(F)cc(-c3nc(Nc4ccc(CN5CCN(c6cn(CCOCCOCCOCCOCCNc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)nn6)CC5)cn4)ncc3F)cc2n1C(C)C,Active,No,,4.292820000000003,DC50 for CDK4 > 500 nM,Efrat Resnick,145.5 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,3,,,Abemaciclib,CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1,CCOCCOCCOCCOCCnnn,Other,17,7,13,1021.0999999999997,No,,5L2S,6ZZ,31330105,CP-A4,No,,Reviewed,Q00534,No,No,No,No,,238.20999999999998
+444,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Inactive,No,,1.773920000000004,,"Efrat Resnick, Yangwode Jing",,< 20 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,13,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCOCCOCC=O,PEG,9,3,6,831.949,No,,4CI3,Y70,30672516,CRBN-2-2-2-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,225.67
+445,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Inactive,No,,1.7905200000000052,,"Efrat Resnick, Yangwode Jing",,< 20 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCOCCOCCOCC=O,PEG,12,4,9,876.002,No,,4CI3,Y70,30672516,CRBN-2-2-2-2-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,234.89999999999998
+446,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCOCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Inactive,No,,2.9608200000000044,,"Efrat Resnick, Yangwode Jing",,< 20 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCOCCOCCOCCCCC=O,non-PEG polyether,15,4,12,918.0829999999999,No,,4CI3,Y70,30672516,CRBN-2-2-2-5-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,234.89999999999998
+447,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCOCCCCCOCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,Yes,MM1S,5.674920000000003,,"Efrat Resnick, Yangwode Jing",1.5 nM,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,13,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCOCCCCCOCCCCC=O,non-PEG polyether,19,3,16,972.2189999999996,No,,4CI3,Y70,30672516,CRBN-6-5-5-VHL,No,,Reviewed,Q96SW2,Yes,Yes,No,Yes,24,225.67
+448,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCCCOCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,,6.455120000000004,,"Efrat Resnick, Yangwode Jing",,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,13,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCOCCCCCCOCCCCCC=O,non-PEG polyether,21,3,18,1000.2729999999995,No,,4CI3,Y70,30672516,CRBN-6-6-6-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,225.67
+449,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,,5.691520000000005,,"Efrat Resnick, Yangwode Jing",,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCOCCCCOCCCCOCCCCCC=O,non-PEG polyether,22,4,19,1016.2719999999995,No,,4CI3,Y70,30672516,CRBN-4-4-4-6-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,234.89999999999998
+450,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCOCCOCCOCCOCCOCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,,4.961120000000009,,"Efrat Resnick, Yangwode Jing",,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,17,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCOCCOCCOCCOCCOCCOCCCCCC=O,non-PEG polyether,29,7,26,1120.3769999999988,No,,4CI3,Y70,30672516,CRBN-6-(2)5-6-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,262.59
+451,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOCCCCOCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,,7.268520000000008,,"Efrat Resnick, Yangwode Jing",,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCOCCCCOCCCCOCCCCOCCCCCC=O,non-PEG polyether,29,5,26,1116.4329999999986,No,,4CI3,Y70,30672516,CRBN-6-(4)3-6-VHL,No,,Reviewed,Q96SW2,No,No,No,No,,244.12999999999997
+452,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(CC(=O)NCCOCCOCC(=O)NCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1,Active,Yes,Ramos,2.2671000000000037,,Ella Livnah,,85 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,17,4,,0.159 uM,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCOCC(=O)NCCOCCO,PEG,17,7,12,932.9919999999997,No,,,,30601480,8c,No,,Reviewed,Q06187,No,No,No,No,16,260.76
+453,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(CC(=O)NCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1,Inactive,No,Ramos,3.1177,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,3,,0.102 uM,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCO,PEG,7,3,4,787.8340000000001,No,,,,30601480,10,No,,Reviewed,Q06187,No,No,No,No,16,213.2
+454,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(CC(=O)NCCOCCOCCC(=O)NCCOCCOCC(=O)NCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1,Active,No,Ramos,1.8066000000000084,,Ella Livnah,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,20,5,,0.108 uM,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,NCCOCCOCCC(=O)NCCOCCOCC(=O)NCCOCCO,PEG,28,11,21,1092.1769999999995,No,,,,30601480,12,No,,Reviewed,Q06187,No,No,No,No,16,308.31999999999994
+461,COc1cc(C(=O)NCCOCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Active,No,HCT116,10.339739999999995,,Adi Rogel,32 nM,98 %,COc1cc(C(N)=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F,Mdm2,,,ester_to_amide,14,4,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCOCCOCCOCCN,PEG,12,4,9,1173.6119999999994,No,,,,30385614,A1874,No,,Reviewed,O60885,Yes,No,No,No,24,203.10999999999999
+462,NC(=O)c1cccc2cn(-c3ccc(-c4cn(CCOCCOCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)nc12,Inactive,No,MDA-MB-231,1.9626,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,15,3,,,Niraparib derivative,NC(=O)c1cccc2cn(-c3ccccc3)nc12,CCOCCOCCOCCOCCn1ccnn1,Other,19,7,13,779.811,No,,4R6E,3JD,30540295,1,No,,Reviewed,P09874,No,No,No,No,,224.12
+463,Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)C(NC(=O)CCC(=O)NCCOCCOCCOCCn2cc(-c3ccc(-n4cc5cccc(C(N)=O)c5n4)cc3)nn2)C(C)(C)C)cc1,Inactive,No,MDA-MB-231,3.5701200000000055,,Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_C,16,5,,,Niraparib derivative,NC(=O)c1cccc2cn(-c3ccccc3)nc12,O=CCCC(=O)NCCOCCOCCOCCn1ccnn1,Other,23,9,15,992.1729999999994,No,,4R6E,3JD,30540295,2,No,,Reviewed,P09874,No,No,No,No,,260.03999999999996
+464,COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCCOCCn3cc(-c4ccc(-n5cc6cccc(C(N)=O)c6n5)cc4)nn3)C(=O)C2)cc1OC(C)C,Active,Yes,MDA-MB-231,7.17730000000001,"EC50 of PROTAC is 8.45 ± 0.54uM (24h treatment), 6.12 ± 0.204uM (48h treatment)",Efrat Resnick,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,aryl_C,16,2,,,Niraparib derivative,NC(=O)c1cccc2cn(-c3ccccc3)nc12,CC(=O)NCCOCCOCCOCCOCCn1ccnn1,Other,23,9,15,1145.114999999999,No,,4R6E,3JD,30540295,3,No,,Reviewed,P09874,No,Yes,No,Yes,"24,48",232.31999999999996
+465,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCn4cc(CCCC(=O)N5CCN(C(=O)c6cc(Cc7n[nH]c(=O)c8ccccc78)ccc6F)CC5)nn4)c3C2=O)C(=O)N1,Inactive,No,MDA-MB-231,2.1315000000000057,,Efrat Resnick,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,3,,,Olaparib derivative,C=Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)CCC)CC3)c2)n[nH]c(=O)c1C,CCOCCOCCOCCOCCn1ccnn1,Other,19,7,13,979.0359999999997,No,,,,30540295,4,No,,Reviewed,P09874,No,No,No,No,,249.57999999999996
+466,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCOCCOCCOCCOCCn3cc(CCCC(=O)N4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)nn3)C(=O)C2)cc1OC(C)C,Inactive,No,MDA-MB-231,7.346200000000011,,Efrat Resnick,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,other,17,2,,,Olaparib derivative,C=Cc1c(Cc2ccc(F)c(C(=O)N3CCN(C(=O)CCC)CC3)c2)n[nH]c(=O)c1C,CC(=O)NCCOCCOCCOCCOCCn1ccnn1,Other,23,9,15,1344.3399999999988,No,,,,30540295,5,No,,Reviewed,P09874,No,No,No,No,,257.78000000000003
+467,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOc2ccc3c(c2)sc2nc(-c4ccc(NC(=O)Nc5cc(C(C)(C)C)on5)cc4)cn23)C(C)(C)C)cc1,Active,Yes,"MV4-11, MOLM-14",8.188620000000007,"IC50 of ligand is FLT-3 ITD 10.3± 0.3nM, FLT-3 WT 7.4± 0.3nM. IC50 of PROTAC is FLT-3 ITD 43± 3.2nM, FLT-3 WT 36± 3nM.",Efrat Resnick,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CO,15,5,< 10.3 nM,< 43 nM,quizartinib,CCOc1ccc2c(c1)sc1nc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)cn12,O=CCCOCCO,PEG,8,3,5,1020.2479999999998,other kinases,,,,30427680,FLT-3 PROTAC,No,,Reviewed,P36888,Yes,No,No,No,,223.77999999999994
+468,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NC(CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)NC5C(C)(C)C(Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,Yes,LnCap,9.255720000000004,,Paul Gehrtz,8.0 nM,,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)C)on1,VHL,,,other,12,3,,,ARI-16,CC1(C)C(NC(=O)c2cnn(CCO)c2)C(C)(C)C1Oc1ccc(C#N)c(Cl)c1,cc(-c)C#CC1CCN(C2CCN(C(C)=O)CC2)CC1,Alkane,20,3,1,1095.8079999999995,No,,,,31931431,ARD-61-HXC (7),Yes,,Reviewed,P10275,No,Yes,No,Yes,6,194.22999999999996
+469,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NC(CC(=O)N2CCC(N3CCC(C#Cc4ccc(N5C(=S)N(c6cnc(C#N)c(C(F)(F)F)c6)C(=O)C56CCC6)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LnCap,8.464920000000008,,Paul Gehrtz,,,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)C)on1,VHL,,,other,13,2,,,Apalutamide,CNC(=O)c1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F,CC(=O)N1CCC(N2CCC(C)CC2)CC1,Alkane,16,3,1,1115.3179999999993,No,,,,31931431,ARD-77-HXC (8),No,,Reviewed,P10275,No,Yes,No,Yes,6,192.33999999999997
+470,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NC(CC(=O)N2CCC(N3CCC(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LnCap,8.925820000000005,,Paul Gehrtz,,,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)C)on1,VHL,,,other,12,2,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CC(=O)N1CCC(N2CCC(C)CC2)CC1,Alkane,16,3,1,1102.3189999999995,No,,,,31931431,ARD-86-HXC (9),No,,Reviewed,P10275,No,Yes,No,Yes,6,179.44999999999993
+471,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NC(CC(=O)N2CCC(N3CCC(C#Cc4ccc(S(=O)(=O)CC(C)(O)C(=O)Nc5ccc(C#N)c(C(F)(F)F)c5)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Inactive,No,LnCap,7.17252000000001,,Paul Gehrtz,,,Cc1cc(C(C(=O)N2C[C@H](O)CC2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)C)on1,VHL,,,other,14,4,,,Bicalutamide,CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1,C#CC1CCN(C2CCN(C(C)=O)CC2)CC1,Alkane,17,3,1,1125.3059999999996,No,,,,31931431,ARD-111-HXC (10),No,,Reviewed,P10275,No,Yes,No,Yes,6,239.36999999999995
+472,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCCOCCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,Yes,"MDA-MB-231, HeLa",8.884720000000003,DC50 error ± 1.0 nM. DMAX error ± 1.1 %.,Ella Livnah,9.5 nM,99.6 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,foretinib,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1O,CCCCOCCCCOCC=O,PEG,13,3,10,1120.2859999999987,No,,,,30631068,SJFα,No,,Reviewed,"O15264, Q16539",No,No,Yes,Yes,"0.5,1.5,3,6,24",228.87
+473,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCOCCOCCOc1cc(-c2scnc2C)ccc1CNC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)C)N1Cc2ccccc2C1=O,Active,No,"MDA-MB-231, HeLa",8.852820000000005,DC50 error ± 81.3 nM. DMAX error ± 10.1 %.,Ella Livnah,45.9 nM,34.5 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H](C(C)C)N2Cc3ccccc3C2=O)c(O)c1,VHL,,,other,15,4,,,foretinib,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1O,CCOCCOCC,PEG,8,2,5,1168.2859999999994,No,,,,30631068,SJFδ,No,,Reviewed,"O15264, Q16539",No,No,Yes,Yes,"0.5,1.5,3,6,24",229.31
+474,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCNC(=O)c2cccc(-c3cc(Nc4ccc(OC(F)(F)F)cc4)ncn3)c2)C(C)(C)C)cc1,Active,No,K562,5.773220000000006,,Adi Rogel,2 uM,85 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,GNF-5,O=C(NCCO)c1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)c1,CC=O,PEG,3,1,0,888.9700000000001,No,,3K5V,STJ,31311809,GMB-101,No,,Reviewed,P00519,No,No,No,No,18,196.99999999999994
+475,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2cccc(-c3cc(Nc4ccc(OC(F)(F)F)cc4)ncn3)c2)C(C)(C)C)cc1,Active,Yes,K562,6.4222200000000065,,Adi Rogel,340 nM,95 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,4,,,GNF-5 analog,Oc1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)c1,CCOCC=O,PEG,6,2,3,861.9440000000002,No,,3K5V,STJ,31311809,GMB-475,Yes,,Reviewed,P00519,Yes,No,No,Yes,18,177.13
+476,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)oc12,Inactive,No,MCF-7,3.858900000000001,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,11,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCO,Alkane,8,2,5,669.6430000000003,No,,,,30196207,8a,No,,Reviewed,P50750,No,No,No,No,24,201.77999999999997
+477,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)oc12,Inactive,No,MCF-7,4.249000000000001,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,11,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCO,Alkane,9,2,6,683.6700000000002,No,,,,30196207,8b,No,,Reviewed,P50750,No,No,No,No,24,201.77999999999997
+478,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)oc12,Active,No,MCF-7,4.639100000000003,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,11,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCCO,Alkane,10,2,7,697.6970000000002,No,,,,30196207,8c,No,,Reviewed,P50750,No,No,No,No,24,201.77999999999997
+479,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCCCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)oc12,Active,No,MCF-7,5.419300000000004,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,11,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCCCCO,Alkane,12,2,9,725.7510000000002,No,,,,30196207,8d,No,,Reviewed,P50750,No,No,No,No,24,201.77999999999997
+480,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCc4cn(CCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,No,MCF-7,3.6506000000000007,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCn1cc(CO)nn1,Other,14,5,7,750.721,No,,,,30196207,11a,No,,Reviewed,P50750,No,No,No,No,24,232.48999999999995
+481,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCc4cn(CCCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,No,MCF-7,4.040700000000001,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCn1cc(CO)nn1,Other,15,5,8,764.748,No,,,,30196207,11b,No,,Reviewed,P50750,No,No,No,No,24,232.48999999999995
+482,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCc4cn(CCCCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,Yes,MCF-7,4.430800000000001,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCCn1cc(CO)nn1,Other,16,5,9,778.7750000000001,No,,,,30196207,11c,No,,Reviewed,P50750,No,No,No,No,24,232.48999999999995
+483,COc1c(O)cc(O)c2c(=O)cc(-c3ccc(OCc4cn(CCCCCCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)nn4)cc3)oc12,Active,No,MCF-7,5.211000000000004,EC50 of ligand and PROTAC was measured in MCF-7 cell line,Adi Rogel,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,4,,,Wogonin,COc1c(O)cc(O)c2c(=O)cc(-c3ccccc3)oc12,O=CCCCCCCCCCn1cc(CO)nn1,Other,18,5,11,806.8290000000001,No,,,,30196207,11d,No,,Reviewed,P50750,No,No,No,Yes,24,232.48999999999995
+484,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,4.638640000000008,,"Ella Livnah, Yangwode Jing",,77 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,17,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCOCCOCCOCC=O,PEG,12,4,9,1101.2939999999999,No,,,,31461270,DAT1,No,,Reviewed,Q96BR1,No,No,No,Yes,"8,16,48",261.65000000000003
+485,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4c(C)n[nH]c4n3)cc2)c1,Inactive,No,HEK293,5.161540000000008,,"Ella Livnah, Yangwode Jing",,16 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,18,5,,,Sanofi 290-R,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4c(C)n[nH]c4n3)cc2)c1,CCOCCOCCOCC=O,PEG,12,4,9,1147.7749999999999,No,,,,31461270,DAT2,No,,Reviewed,Q96BR1,No,No,No,No,48,270.88
+486,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCC(=O)NCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CCO4)c4cn[nH]c4n3)cc2)c1,Inactive,No,HEK293,2.027120000000004,,"Ella Livnah, Yangwode Jing",,30 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCNC(=O)COCCOCCOCC,PEG,15,5,10,987.0369999999998,No,,,,31461270,DAT3,No,,Reviewed,Q96BR1,No,No,No,No,48,274.7
+487,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCC(=O)NCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CCO4)c4c(C)n[nH]c4n3)cc2)c1,Inactive,No,HEK293,2.5500200000000044,,"Ella Livnah, Yangwode Jing",,16 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,5,,,Sanofi 290-R,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4c(C)n[nH]c4n3)cc2)c1,CCNC(=O)COCCOCCOCC,PEG,15,5,10,1033.5179999999998,No,,,,31461270,DAT4,No,,Reviewed,Q96BR1,No,No,No,No,48,283.93
+488,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,4.622040000000006,,"Ella Livnah, Yangwode Jing",,64 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,16,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCOCCOCC=O,PEG,9,3,6,1057.2409999999998,No,,,,31461270,DAT5,No,,Reviewed,Q96BR1,No,No,No,No,48,252.42000000000002
+489,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,4.65524000000001,,"Ella Livnah, Yangwode Jing",,80 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,18,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCOCCOCCOCCOCC=O,PEG,15,5,12,1145.347,No,,,,31461270,DAT6,No,,Reviewed,Q96BR1,No,No,No,No,48,270.88
+490,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,4.67184000000001,,"Ella Livnah, Yangwode Jing",,63 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,19,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCOCCOCCOCCOCCOCC=O,PEG,18,6,15,1189.4,No,,,,31461270,DAT7,No,,Reviewed,Q96BR1,No,No,No,No,48,280.11
+491,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCCCCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,Yes,"HEK293, CAMA-1, ZR-75-1",6.199040000000008,,"Ella Livnah, Yangwode Jing",< 100 nM,81 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,17,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCCCCCOCCOCCOCC=O,PEG,16,4,13,1157.402,No,,,,31461270,"DAT8, SGK3-PROTAC1",Yes,,Reviewed,Q96BR1,Yes,No,No,No,"2,48",261.65000000000003
+492,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCCCCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,6.215640000000009,,"Ella Livnah, Yangwode Jing",,88 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,18,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCCCCCOCCOCCOCCOCC=O,PEG,19,5,16,1201.4550000000002,No,,,,31461270,DAT9,No,,Reviewed,Q96BR1,No,No,No,No,48,270.88
+493,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCCCCCOCCCCCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,7.742840000000009,,"Ella Livnah, Yangwode Jing",,91 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,16,5,,,Sanofi 308-R,Cc1ccc(F)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4cn[nH]c4n3)cc2)c1,CCCCCCOCCCCCCOCC=O,non-PEG polyether,17,3,14,1169.4570000000003,No,,,,31461270,DAT10,No,,Reviewed,Q96BR1,No,No,No,No,48,252.42000000000002
+494,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCCCCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4c(C)n[nH]c4n3)cc2)c1,Active,No,HEK293,6.73854000000001,,"Ella Livnah, Yangwode Jing",,71 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,19,5,,,Sanofi 290-R,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4c(C)n[nH]c4n3)cc2)c1,CCCCCCOCCOCCOCCOCC=O,PEG,19,5,16,1247.9359999999997,No,,,,31461270,DAT11,No,,Reviewed,Q96BR1,No,No,No,No,48,280.11
+495,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CN(CCCCCCOCCCCCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)CCO4)c4cn[nH]c4n3)cc2)c1,Active,No,HEK293,7.957320000000008,,"Ella Livnah, Yangwode Jing",,71 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,5,,,Sanofi 290-R,COc1ccc(Cl)c(S(=O)(=O)Nc2ccc(-c3nc(OC[C@H]4CNCCO4)c4c(C)n[nH]c4n3)cc2)c1,CCCCCCOCCCCCCOCC=O,non-PEG polyether,17,3,14,1201.911,No,,,,31461270,DAT12,No,,Reviewed,Q96BR1,No,No,No,No,48,261.65000000000003
+496,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCc4cn(CCCC(=O)N5CCN(CC#Cc6ccc(OCCCc7sc(N8CCc9cccc(C(=O)Nc%10nc%11ccccc%11s%10)c9C8)nc7C(=O)O)c(F)c6)CC5)nn4)c3C2=O)C(=O)N1,Active,Yes,MOLT4,6.030800000000005,"Selective BCLXL degradation: only in MOLT4 cells, not platelets",Paul Gehrtz,50 nM,85 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,20,4,0.005 nM,0.009 nM,A-1155463,CN(C)CC#Cc1ccc(OCCCc2sc(N3CCc4cccc(C(=O)Nc5nc6ccccc6s5)c4C3)nc2C(=O)O)c(F)c1,CCOCCOCc1cn(CCCC(=O)N(C)C)nn1,non-PEG polyether,20,7,10,1221.364,No,,4QVX,3CQ,31754664,XZ424,No,,Reviewed,Q07817,Yes,No,No,Yes,16,272.94999999999993
+497,COc1cc(/C=C(\C#N)C(=O)NCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.049400000000009,DCmax was measured in 100nM,Amit Shraga,,50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,7.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CC,Alkane,2,0,0,900.9430000000002,No,,3K6P,5FB,31097997,6a,No,,Reviewed,P62508,No,No,No,No,4,165.91
+498,COc1cc(/C=C(\C#N)C(=O)NCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.4395000000000095,DCmax was measured in 100nM,Amit Shraga,,85 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,6.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCC,Alkane,3,0,0,914.9700000000001,No,,3K6P,5FB,31097997,6b,No,,Reviewed,P62508,No,No,No,No,4,165.91
+499,COc1cc(/C=C(\C#N)C(=O)NCCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,Yes,MDA-MB-231,7.829600000000012,"selective towards ERRa (tested also against ERRb, ERRg). DCmax was measured in 100nM",Amit Shraga,,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,12.67 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCC,Alkane,4,0,1,928.9970000000002,No,,3K6P,5FB,31097997,6c,No,,Reviewed,P62508,Yes,Yes,Yes,Yes,4,165.91
+500,COc1cc(/C=C(\C#N)C(=O)NCCCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,8.21970000000001,DCmax was measured in 100nM,Amit Shraga,,78 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,5.67 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCC,Alkane,5,0,2,943.0240000000001,No,,3K6P,5FB,31097997,6d,No,,Reviewed,P62508,No,No,No,No,4,165.91
+501,COc1cc(/C=C(\C#N)C(=O)NCCCCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,8.609800000000007,DCmax was measured in 100nM,Amit Shraga,,71 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,12.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCCC,Alkane,6,0,3,957.051,No,,3K6P,5FB,31097997,6e,No,,Reviewed,P62508,No,No,No,No,4,165.91
+502,COc1cc(/C=C(\C#N)C(=O)NCCCCCCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,8.999900000000004,DCmax was measured in 100nM,Amit Shraga,,9 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,4,5.67 nM,7.67 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCCCC,Alkane,7,0,4,971.0780000000001,No,,3K6P,5FB,31097997,6f,No,,Reviewed,P62508,No,No,No,No,4,165.91
+503,COc1cc(/C=C(\C#N)C(=O)NCCOCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.023500000000009,DCmax was measured in 100nM,Amit Shraga,,92 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,11,4,5.67 nM,11.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOC,PEG,4,1,1,930.969,No,,3K6P,5FB,31097997,6g,No,,Reviewed,P62508,No,No,No,No,4,175.13999999999996
+504,COc1cc(/C=C(\C#N)C(=O)NCCOCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.06600000000001,DCmax was measured in 100nM,Amit Shraga,,89 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,11,4,5.67 nM,9.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCC,PEG,5,1,2,944.9960000000001,No,,3K6P,5FB,31097997,6h,No,,Reviewed,P62508,No,No,No,No,4,175.13999999999996
+505,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.082600000000011,DCmax was measured in 100 nM,Amit Shraga,,19 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,4,5.67 nM,5.33 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCC,PEG,8,2,5,989.0490000000001,No,,3K6P,5FB,31097997,6i,No,,Reviewed,P62508,No,No,No,No,4,184.36999999999998
+506,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCOCCN[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Active,No,MDA-MB-231,7.099200000000011,DCmax was measured in 100 nM,Amit Shraga,,10 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,4,5.67 nM,7.00 nM,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCCOCC,PEG,11,3,8,1033.1019999999999,No,,3K6P,5FB,31097997,6j,No,,Reviewed,P62508,No,No,No,No,4,193.6
+507,COc1cc(/C=C(\C#N)C(=O)NCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,5.628480000000005,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,9,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCC,Alkane,4,0,1,771.6710000000004,No,,3K6P,5FB,31097997,7a,No,,Reviewed,P62508,No,No,No,No,,166.92999999999998
+508,COc1cc(/C=C(\C#N)C(=O)NCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,6.408680000000006,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,9,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCCC,Alkane,6,0,3,799.7250000000003,No,,3K6P,5FB,31097997,7b,No,,Reviewed,P62508,No,No,No,No,,166.92999999999998
+509,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,4.881480000000003,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,11,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCC,PEG,8,2,5,831.7230000000003,No,,3K6P,5FB,31097997,7c,No,,Reviewed,P62508,No,No,No,No,,185.39
+510,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,4.898080000000004,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCCOCC,PEG,11,3,8,875.7760000000004,No,,3K6P,5FB,31097997,7d,No,,Reviewed,P62508,No,No,No,No,,194.61999999999998
+511,COc1cc(/C=C(\C#N)C(=O)NCCCOCCCCOCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,6.4418800000000065,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,11,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCOCCCCOCCC,PEG,12,2,9,887.8310000000005,No,,3K6P,5FB,31097997,7e,No,,Reviewed,P62508,No,No,No,No,,185.39
+512,COc1cc(/C=C(\C#N)C(=O)NCCCOCCOCCOCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,5.678280000000005,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCOCCOCCOCCC,PEG,13,3,10,903.8300000000004,No,,3K6P,5FB,31097997,7f,No,,Reviewed,P62508,No,No,No,No,,194.61999999999998
+513,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,4.914680000000005,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCCOCCOCC,PEG,14,4,11,919.8290000000003,No,,3K6P,5FB,31097997,7g,No,,Reviewed,P62508,No,No,No,No,,203.85
+514,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCOCCOCCOCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,4.931280000000007,,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,3,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCCOCCOCCOCC,PEG,17,5,14,963.8820000000003,No,,3K6P,5FB,31097997,7h,No,,Reviewed,P62508,No,No,No,No,,213.07999999999998
+515,COc1cc(/C=C(\C#N)C(=O)NCCCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc2ccccc2)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,5.693180000000007,,Amit Shraga,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,other,8,5,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCN,Alkane,5,1,2,805.8170000000003,No,,3K6P,5FB,31097997,8a,No,,Reviewed,P62508,No,No,No,No,,175.79999999999998
+516,COc1cc(/C=C(\C#N)C(=O)NCCOCCOCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc2ccccc2)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,Inactive,No,MDA-MB-231,4.946180000000005,,Amit Shraga,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,other,10,5,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCOCCOCCN,PEG,9,3,6,865.8690000000004,No,,3K6P,5FB,31097997,8b,No,,Reviewed,P62508,No,No,No,No,,194.26
+517,COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)CCNC(=O)/C(C#N)=C/c3ccc(OCc4ccc(C(F)(F)F)cc4C(F)(F)F)c(OC)c3)C(=O)C2)c(OC(C)C)c1,Inactive,No,MDA-MB-231,10.905979999999994,,Amit Shraga,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,other,10,1,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCC(C)=O,Alkane,5,1,1,1093.9059999999997,No,,3K6P,5FB,31097997,9a,No,,Reviewed,P62508,No,No,No,No,,163.1
+518,COc1ccc(C2=N[C@@H](c3ccc(Cl)cc3)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCN(CC(=O)NCCCCCNC(=O)/C(C#N)=C/c3ccc(OCc4ccc(C(F)(F)F)cc4C(F)(F)F)c(OC)c3)C(=O)C2)c(OC(C)C)c1,Inactive,No,MDA-MB-231,11.233279999999993,,Amit Shraga,,,COc1ccc(C2=N[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1,Mdm2,,,other,10,2,,,XCT790 4a with thiadiazoloacylamide removed,COc1cc(/C=C(\C#N)C(N)=O)ccc1OCc1ccc(C(F)(F)F)cc1C(F)(F)F,CCCCCNC(C)=O,Alkane,9,2,4,1151.0019999999995,No,,3K6P,5FB,31097997,9b,No,,Reviewed,P62508,No,No,No,No,,175.12999999999997
+519,CCN(CCOCCOCCOCC#Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,5.773700000000007,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,3,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,C#CCOCCOCCO,PEG,10,3,6,845.9710000000003,No,,1ERR,RAL,30990042,12,No,,Reviewed,P03372,No,No,No,No,4,164.17
+520,CCN(CCCCCCC#Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,7.67440000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,9,3,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,C#CCCC,Alkane,5,0,1,783.9470000000003,No,,1ERR,RAL,30990042,13,No,,Reviewed,P03372,No,No,No,No,4,136.48000000000002
+521,CCN(CCOCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,8.153120000000012,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 99.4 %).,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,15,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,O=CCCOCCOCCO,PEG,11,4,8,1064.3369999999998,No,,1ERR,RAL,30990042,14,No,,Reviewed,P03372,No,No,No,No,4,209.31999999999996
+522,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,10.053819999999996,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 99.6 %).,Amit Shraga,,79 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1002.3129999999999,No,,1ERR,RAL,30990042,15,No,,Reviewed,P03372,No,No,No,No,4,181.63
+523,CCN(CCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,8.493420000000006,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,37 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,C=O,Alkane,2,1,0,946.2049999999999,No,,1ERR,RAL,30990042,16,No,,Reviewed,P03372,No,No,No,No,4,181.63
+524,CCN(CCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,8.883520000000003,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,10 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CC=O,Alkane,3,1,0,960.2319999999999,No,,1ERR,RAL,30990042,17,No,,Reviewed,P03372,No,No,No,No,4,181.63
+525,CCN(CCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,9.273620000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,74 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCC=O,Alkane,4,1,1,974.2589999999999,No,,1ERR,RAL,30990042,18,No,,Reviewed,P03372,No,No,No,No,4,181.63
+526,CCN(CCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,9.663719999999998,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,68 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCC=O,Alkane,5,1,2,988.286,No,,1ERR,RAL,30990042,19,No,,Reviewed,P03372,No,No,No,No,4,181.63
+527,CCN(CCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,10.443919999999993,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,77 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCCC=O,Alkane,7,1,4,1016.3399999999998,No,,1ERR,RAL,30990042,20,No,,Reviewed,P03372,No,No,No,No,4,181.63
+528,CCN(CCCCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,10.83401999999999,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,75 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCCCC=O,Alkane,8,1,5,1030.367,No,,1ERR,RAL,30990042,21,No,,Reviewed,P03372,No,No,No,No,4,181.63
+529,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(C)CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C(C)(C)C)cc1,Inactive,No,MCF-7,9.663720000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 0 %).,Amit Shraga,,73 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCC=O,Alkane,5,1,2,988.2860000000001,No,,1ERR,RAL,30990042,22,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+530,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C(C)C)C(C)(C)C)cc1,Active,No,MCF-7,10.442319999999995,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,72 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1016.34,No,,1ERR,RAL,30990042,23,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+531,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C(C)(C)C)C(C)(C)C)cc1,Active,No,MCF-7,10.832419999999992,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,79 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1030.367,No,,1ERR,RAL,30990042,24,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+532,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C2CC2)C(C)(C)C)cc1,Active,No,MCF-7,10.196319999999996,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,80 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1014.324,No,,1ERR,RAL,30990042,25,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+533,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C2CCC2)C(C)(C)C)cc1,Active,No,MCF-7,10.586419999999993,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,85 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1028.3509999999999,No,,1ERR,RAL,30990042,26,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+534,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C2CCCC2)C(C)(C)C)cc1,Active,No,MCF-7,10.976519999999988,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,25 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1042.378,No,,1ERR,RAL,30990042,27,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+535,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C2CCCCC2)C(C)(C)C)cc1,Active,No,MCF-7,11.366619999999987,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,32 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1056.4049999999997,No,,1ERR,RAL,30990042,28,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+536,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)CC2CCC2)C(C)(C)C)cc1,Active,No,MCF-7,10.834019999999992,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99 %).,Amit Shraga,,24 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,1042.378,No,,1ERR,RAL,30990042,29,No,,Reviewed,P03372,No,No,No,No,4,181.62999999999997
+537,CCN(CCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,8.136520000000012,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 97.6 %).,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,O=CCCOCCO,PEG,8,3,5,1020.2839999999998,No,,1ERR,RAL,30990042,30,No,,Reviewed,P03372,No,No,No,No,4,200.08999999999995
+538,CCN(CCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,7.746420000000012,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM > 99.6 %).,Amit Shraga,,6 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,O=CCOCCO,PEG,7,3,4,1006.2569999999998,No,,1ERR,RAL,30990042,31,No,,Reviewed,P03372,No,No,No,No,4,200.08999999999995
+539,CCN(CCCCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,Yes,MCF-7,8.900120000000005,"EC50 of PROTAC was measured in MCF7 cell line. DC50 is 0.17 nM MCF-7, 0.43 T47D. EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 5 nM > 95 %).",Amit Shraga,< 0.43 nM,92 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCOCC=O,Alkane,6,2,3,1004.2849999999999,No,,1ERR,RAL,30990042,32 / ERD-308,No,,Reviewed,P03372,No,Yes,No,Yes,"1,3,4",190.85999999999999
+540,CCN(CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1)CCC1CCN(CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,MCF-7,9.595520000000002,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCN(CC)CCCC=O,Other,10,2,6,1057.3929999999996,No,,1ERR,RAL,30990042,33,No,,Reviewed,P03372,No,No,No,No,4,184.87
+541,CCN(CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1)CCN1CCN(CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Active,No,MCF-7,8.11102000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 50 %).,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,O=CCCCN1CCNCC1,Other,11,3,4,1058.3809999999996,No,,1ERR,RAL,30990042,34,No,,Reviewed,P03372,No,No,No,No,4,188.10999999999996
+542,CCN(CCCC#Cc1cnn(CCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)c1)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,9.131720000000003,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 99.5 %).,Amit Shraga,,30 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,C#Cc1cnn(CCC=O)c1,Other,11,3,3,1064.3439999999998,No,,1ERR,RAL,30990042,35,No,,Reviewed,P03372,No,No,No,No,4,199.44999999999996
+543,CCN(CCC#Cc1cnn(CC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)c1)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,8.35152000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 55 %).,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,Cc1cnn(CC=O)c1,Other,9,3,2,1036.29,No,,1ERR,RAL,30990042,36,No,,Reviewed,P03372,No,No,No,No,4,199.44999999999996
+544,CCN(CCCCc1cnn(CC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)c1)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Active,No,MCF-7,8.932620000000005,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 80 %).,Amit Shraga,,1 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,Cc1cnn(CC=O)c1,Other,9,3,2,1040.322,No,,1ERR,RAL,30990042,37,No,,Reviewed,P03372,No,No,No,No,4,199.44999999999996
+545,CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCN(CC)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)cc1)c1ccccc1,Active,No,MCF-7,10.604619999999995,DCmax was measured in 1 nM (at 76 nM 80 %).,Amit Shraga,,45 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,9,4,,,tamoxifen,CC[N]CCOc1ccc(/C(=C(/CC)c2ccccc2)c2ccc(O)cc2)cc1,CCCCCC=O,Alkane,7,1,4,956.307,No,,,,30990042,38,No,,Reviewed,P03372,No,No,No,No,4,144.32999999999998
+546,CC/C(=C(\c1ccccc1)c1ccc(OCCN(CC)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](C)c2ccc(-c3scnc3C)cc2)C(C)(C)C)cc1)c1ccccc1,Active,No,MCF-7,10.899019999999993,DCmax was measured in 1 nM (at 10 nM 3 %).,Amit Shraga,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,8,3,,,4-hydroxytamoxifen,CC[N]CCOc1ccc(/C(=C(/CC)c2ccccc2)c2ccccc2)cc1,CCCCCC=O,Alkane,7,1,4,940.308,No,,,,30990042,39,No,,Reviewed,P03372,No,No,No,No,4,124.10000000000001
+547,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(Cn2c(-c3ccc(O)cc3)c(C)c3cc(O)ccc32)cc1,Active,No,MCF-7,9.919539999999998,DCmax was measured in 1 nM (at 90 nM 3 %).,Amit Shraga,,26 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,11,5,,,bazedoxifene,CC[N]CCOc1ccc(Cn2c(-c3ccc(O)cc3)c(C)c3cc(O)ccc32)cc1,CCCCCC=O,Alkane,7,1,4,985.3049999999997,No,,,,30990042,40,No,,Reviewed,P03372,No,No,No,No,4,169.49
+548,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc([C@@H]2c3ccc(O)cc3CC[C@@H]2c2ccccc2)cc1,Active,No,MCF-7,10.097419999999998,DCmax was measured in 1 nM (at 10 nM 95 %).,Amit Shraga,,26 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,9,4,,,lasofoxifene,CC[N]CCOc1ccc([C@@H]2c3ccc(O)cc3CC[C@@H]2c2ccccc2)cc1,CCCCCC=O,Alkane,7,1,4,956.3069999999998,No,,,,30990042,41,No,,Reviewed,P03372,No,No,No,No,4,144.33
+549,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,9.49282,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 29 %).,Amit Shraga,,21 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,988.286,No,,1ERR,RAL,30990042,42,No,,Reviewed,P03372,No,No,No,No,4,181.63
+550,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(Cl)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,9.275300000000001,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,1 %,C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(Cl)cc1,VHL,,,other,10,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,939.616,No,,1ERR,RAL,30990042,43,No,,Reviewed,P03372,No,No,No,No,4,168.74
+551,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C#N)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,8.493580000000007,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(C#N)cc1,VHL,,,other,11,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,930.181,No,,1ERR,RAL,30990042,44,No,,Reviewed,P03372,No,No,No,No,4,192.52999999999997
+552,C#Cc1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCN(CC)CCOc2ccc(C(=O)c3c(-c4ccc(O)cc4)sc4cc(O)ccc34)cc2)C(C)(C)C)cc1,Active,No,MCF-7,8.603200000000006,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM (at 10 nM 76 %).,Amit Shraga,,10 %,C#Cc1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,929.1930000000003,No,,1ERR,RAL,30990042,45,No,,Reviewed,P03372,No,No,No,No,4,168.73999999999998
+553,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C2CC2)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,9.499300000000002,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(C2CC2)cc1,VHL,,,other,10,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,945.236,No,,1ERR,RAL,30990042,46,No,,Reviewed,P03372,No,No,No,No,4,168.74
+554,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C(C)C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,9.7453,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,CC(C)c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,947.252,No,,1ERR,RAL,30990042,47,No,,Reviewed,P03372,No,No,No,No,4,168.74
+555,CCN(CCCCCCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(C(C)(C)C)cc1)C(C)(C)C)CCOc1ccc(C(=O)c2c(-c3ccc(O)cc3)sc3cc(O)ccc23)cc1,Inactive,No,MCF-7,9.9194,EC50 of ligand was measured in MCF7 cells. DCmax was measured in 1 nM.,Amit Shraga,,,C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)c1ccc(C(C)(C)C)cc1,VHL,,,other,10,5,,,raloxifene,O=C(c1ccc(OCCN2CCCCC2)cc1)c1c(-c2ccc(O)cc2)sc2cc(O)ccc12,CCCCC=O,Alkane,6,1,3,961.279,No,,1ERR,RAL,30990042,48,No,,Reviewed,P03372,No,No,No,No,4,168.74
+556,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)NCCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,MiaPaCa2,3.681320000000002,,Amit Shraga,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,14,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCNC=O,Alkane,7,2,4,817.9079999999996,No,,5L2I,LQQ,30935795,2,No,,Reviewed,Q00534,No,No,No,No,"4,24",220.93
+557,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)NCCCCCCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,MiaPaCa2,5.2417200000000035,,Amit Shraga,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,14,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCCCCNC=O,Alkane,11,2,8,874.0159999999996,No,,5L2I,LQQ,30935795,3,No,,Reviewed,Q00534,No,No,No,No,"4,24",220.93
+558,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCCCCC(=O)Nc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,MiaPaCa2,4.278520000000002,,Amit Shraga,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,14,3,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCC=O,Alkane,7,1,4,816.9199999999997,No,,5L2I,LQQ,30935795,4,No,,Reviewed,Q00534,No,No,No,No,"4,24",208.89999999999998
+559,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCONc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,MiaPaCa2,3.156320000000002,,Amit Shraga,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,3,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCO,PEG,9,3,6,850.9339999999996,No,,5L2I,LQQ,30935795,5,No,,Reviewed,Q00534,No,No,No,No,"4,24",219.51999999999998
+560,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCCOCCOCCOCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,Yes,"MiaPaCa2, HPNE",3.1377200000000034,,Amit Shraga,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,18,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCOCCOCCOCCCNC(C)=O,PEG,17,5,12,964.0939999999996,No,,5L2I,LQQ,30935795,6,No,,Reviewed,Q00534,No,Yes,No,Yes,"4,24",248.62
+561,COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(CC(=O)NCC(=O)Nc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)c2)c(OC)c1,Active,Yes,"MCF-7, MDA-MB-231, HepG2, LO2, B16",2.0053,Dmax is measured in 10uM. EC50 of PROTAC is MCF-7: 2.70 ± 0.19 MDA-MB-231: 21.21 ± 1.95 HepG2: 18.70 ± 1.65 LO2: 41.11 ± 3.70 B16: 22.68 ± 2.03 uM. EC50 of ligand is MCF-7: 4.17 ± 0.31 MDA-MB-231: 21.33 ± 1.96 HepG2: 10.59 ± 0.94 LO2: 35.57 ± 2.81 B16: 14.49 ± 1.28 uM.,Amit Shraga,~ 0.5 uM,81 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,3,,,RGS,CNc1cc(CS(=O)(=O)/C=C/c2c(OC)cc(OC)cc2OC)ccc1OC,CC(=O)NCC=O,Alkane,7,3,2,748.767,No,,,,30901674,2,No,,Reviewed,P15056,No,Yes,No,Yes,"24,72",212.80999999999997
+562,CN1C(=O)CCc2cc3cc(c21)OCCOC[C@H]1CN(C(=O)CCC(=O)NCCCOCCOCCOc2cccc4c2C(=O)N(C2CCC(=O)NC2=O)C4=O)CCN1c1ncc(Cl)c(n1)N3,Active,Yes,"Karpas 422,ULA, SUDHL4, OCI-Ly1, Ramos",2.0087000000000046,"half the paper develops the ligand and checks its selectivity. Dmax is 76% Karpas 422, 59% ULA, 84% SUDHL4, 82% OCI-Ly1, 82% Ramos.",Amit Shraga,~ 1 uM,> 76 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,16,3,0.063 uM,0.12 uM,14,CC(C)CCC(=O)N1CCN2c3ncc(Cl)c(n3)Nc3cc4c(c(c3)OCCOC[C@H]2C1)N(C)C(=O)CC4,NCCCOCCOCCO,PEG,11,4,8,946.4149999999997,No,,6EW8,C0Q,30335946,15,Yes,,Reviewed,P41182,No,Yes,No,Yes,4,240.47
+563,COc1cc(N2CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.104020000000009,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",> 50 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,NC(=O)CCCCCCC=O,Alkane,11,3,7,1055.6839999999995,No,,6MX8,6GY,32179332,compound 8,No,,Reviewed,Q9UM73,No,No,No,No,,211.32000000000005
+564,COc1cc(N2CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.494120000000006,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",15 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,NC(=O)CCCCCCCC=O,Alkane,12,3,8,1069.7109999999996,No,,6MX8,6GY,32179332,compound 9,No,,Reviewed,Q9UM73,No,No,No,No,,211.32000000000005
+565,COc1cc(N2CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.884220000000003,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",> 50 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,NC(=O)CCCCCCCCC=O,Alkane,13,3,9,1083.7379999999996,No,,6MX8,6GY,32179332,compound 10,No,,Reviewed,Q9UM73,No,No,No,No,,211.32000000000005
+566,COc1cc(N2CCC(NC(=O)CCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.540420000000006,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",9.1 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,6,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCC=O,Alkane,7,1,4,1069.7109999999996,No,,6MX8,6GY,32179332,compound 15,No,,Reviewed,Q9UM73,No,No,No,No,,220.11
+567,COc1cc(N2CCC(NC(=O)CCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.930520000000005,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",20.9 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,6,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCC=O,Alkane,8,1,5,1083.7379999999996,No,,6MX8,6GY,32179332,compound 16,No,,Reviewed,Q9UM73,No,No,No,No,,220.11
+568,COc1cc(N2CCC(NC(=O)CCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,9.320620000000003,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",7.2 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,6,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCCC=O,Alkane,9,1,6,1097.7649999999994,No,,6MX8,6GY,32179332,compound 17,No,,Reviewed,Q9UM73,No,No,No,No,,220.11
+569,COc1cc(N2CCC(N3CCN(C(=O)CCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.568420000000007,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",11.4 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCC=O,Alkane,8,1,5,1138.817999999999,No,,6MX8,6GY,32179332,compound 23,No,,Reviewed,Q9UM73,No,No,No,No,,214.56
+570,COc1cc(N2CCC(N3CCN(C(=O)CCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,8.958520000000004,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",25.1 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCCC=O,Alkane,9,1,6,1152.8449999999991,No,,6MX8,6GY,32179332,compound 24,No,,Reviewed,Q9UM73,No,No,No,No,,214.56
+571,COc1cc(N2CCC(N3CCN(C(=O)CCCCCCCCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,No,SR,9.348620000000002,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",7.5 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,5,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCCCC=O,Alkane,10,1,7,1166.8719999999992,No,,6MX8,6GY,32179332,compound 25,No,,Reviewed,Q9UM73,No,No,No,No,,214.56
+572,COc1cc(N2CCC(NC(=O)CCCCCCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(-c4scnc4C)cc3)C(C)(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,Active,Yes,"SR, H2228, NCI–H69, NCI–H1688, NCI–H446",9.710720000000004,"EC50 of ligand is 2.7 ± 0.4nM (SF cells), 58.2 ± 20.7 nM (H2228 cells). EC50 of PROTAC is 1.7 ± 1 nM (SF cells), 46nM ± 16 nM (H2228 cells).","Daniel Zaidman, Yangwode Jing",7.0 nM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,6,,,Brigatinib,COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1,CCCCCCCCC=O,Alkane,10,1,7,1111.7919999999992,No,,6MX8,6GY,32179332,compound 18 (SIAIS117),No,,Reviewed,Q9UM73,Yes,No,No,Yes,,220.11
+573,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOc2ccc(-c3ccc4ncnc(Nc5ccc(OCc6cccc(F)c6)c(Cl)c5)c4c3)cc2)C(C)(C)C)cc1,Active,Yes,"OVCAR8 (WT EGFR), HeLa (EGFR Exon 20 Ins), SKBr3 (HER2)",9.064920000000003,DC50 is for WT EGFR. DC50 for EGFR Exon 20 Ins is 736.2 nM. DMAX is for WT EGFR. DMAX for EGFR Exon 20 Ins is 68.8 %.,Barr Tivon,39.2 nM,97.6 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,4,,,lapatinib-based,CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,CCOCCOCC=O,PEG,9,3,6,1030.62,No,,1XKK,FMM,29129716,compound 1,No,,Reviewed,"P00533, P04626",Yes,No,No,No,24,186.35999999999996
+574,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCCCOCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,No,"HCC827 (Exon 19 del), H3255 (L858R)",7.387920000000008,DC50 is for EGFR (Exon 19 del). DC50 for EGFR (L858R) 22.3 nM. DMAX is for EGFR (Exon 19 del). DMAX for EGFR (L858R) 96.6 %.,Barr Tivon,11.7 nM,98.9 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,13,4,,,gefitinib-based,COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1,CCOCCOCCC=O,PEG,10,3,7,934.532,No,,4WKQ,IRE,29129716,compound 3,No,,Reviewed,P00533,No,No,No,No,24,186.36
+575,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOCCCCOCCCCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2NC(=O)/C=C/CN(C)C)C(C)(C)C)cc1,Active,No,H1975,8.996020000000001,,Barr Tivon,215.8 nM,79.1 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,afatinib-based,CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1,COCCCCOCCCCCC=O,non-PEG polyether,14,3,11,1086.7729999999992,No,,4G5J,0WN,29129716,compound 4,No,,Reviewed,P00533,No,No,No,No,24,209.46999999999997
+576,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOc2ccc(-c3ccc4ncnc(Nc5ccc(OCc6cccc(F)c6)c(Cl)c5)c4c3)cc2)C(C)(C)C)cc1,Active,No,OVCAR8,9.081520000000003,,Barr Tivon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,4,,,lapatinib-based,CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1,CCOCCOCCOCC=O,PEG,12,4,9,1074.6729999999998,No,,1XKK,FMM,29129716,compound 5,No,,Reviewed,P00533,Yes,No,No,No,24,195.58999999999997
+577,COc1cc2c(Oc3ccc(N(C(=O)C4(C(N)=O)CC4)c4ccc(F)cc4)cc3F)ccnc2cc1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,Yes,"MDA-MB-231, GTL16",8.06742000000001,,Barr Tivon,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,4,,,foretinib-based,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1,O=CCCOCCCO,non-PEG polyether,9,3,6,1106.2589999999989,No,,6SD9,88Z,29129716,compound 7,No,,Reviewed,P08581,Yes,No,Yes,Yes,24,234.07
+578,Cc1nnc2n1-c1sc(C#Cc3cnn(-c4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Inactive,No,"RS4;11, MV4;11, MOLM-13,",3.2449200000000022,EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,11,1,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,None,Other,0,0,0,643.6850000000003,"BRD2, BRD3",,,,30019901,26,No,,Reviewed,O60885,No,No,No,No,"3,24,96",141.30999999999997
+579,Cc1nnc2n1-c1sc(C#Cc3cnn(COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,No,"RS4;11, MV4;11, MOLM-13,",3.292220000000002,EC50 of PROTAC is 19.7nM-311nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CO,12,1,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,O,PEG,1,1,0,673.7110000000001,"BRD2, BRD3",,,,30019901,27,No,,Reviewed,O60885,No,No,No,No,"3,24,96",150.54
+580,Cc1nnc2n1-c1sc(C#Cc3cnn(CCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,No,"RS4;11, MV4;11, MOLM-13,",3.367820000000002,EC50 of PROTAC is 0.379nM-2.23nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,12,2,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,CN,Alkane,2,1,0,686.754,"BRD2, BRD3",,,,30019901,28,No,,Reviewed,O60885,No,No,No,No,"3,24,96",153.33999999999997
+581,Cc1nnc2n1-c1sc(C#Cc3cnn(CCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,No,"RS4;11, MV4;11, MOLM-13,",3.757920000000002,EC50 of PROTAC is 0.038nM-0.56nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,12,2,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,CCN,Alkane,3,1,0,700.7810000000001,"BRD2, BRD3",,,,30019901,29,No,,Reviewed,O60885,No,No,No,No,"3,24,96",153.33999999999997
+582,Cc1nnc2n1-c1sc(C#Cc3cnn(CCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,No,"RS4;11, MV4;11, MOLM-13,",4.1480200000000025,EC50 of PROTAC is 0.02nM-0.19nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,12,2,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,CCCN,Alkane,4,1,1,714.808,"BRD2, BRD3",,,,30019901,30,No,,Reviewed,O60885,No,No,No,No,"3,24,96",153.33999999999997
+583,Cc1nnc2n1-c1sc(C#Cc3cnn(CCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,No,"RS4;11, MV4;11, MOLM-13,",4.538120000000004,EC50 of PROTAC is 0.02nM-0.19nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,12,2,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,CCCCN,Alkane,5,1,2,728.835,"BRD2, BRD3",,,,30019901,31,No,,Reviewed,O60885,No,No,No,No,"3,24,96",153.33999999999997
+584,Cc1nnc2n1-c1sc(C#Cc3cnn(CCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2,Active,Yes,"RS4;11, MV4;11, MOLM-13,",4.447420000000004,EC50 of PROTAC is 0.0083nM-0.062nM. EC50 of ligand is 55.8-207 nM.,Daniel Zaidman,< 0.5 nM,100 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,10,1,10.7 nM,,QCA276,Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2,C#CCC,Other,4,0,0,695.8050000000001,"BRD2, BRD3",,,,30019901,35 (QCA570),No,,Reviewed,O60885,Yes,Yes,No,Yes,"3,24,96",124.24
+585,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(C/C=C/C(=O)N3CCC[C@@H](n4nc(-c5ccc(-c6ccccc6)cc5)c5c(N)ncnc54)C3)CC2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Inactive,No,THP-1,5.098700000000015,,Daniel Zaidman,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,other,17,5,,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,CN1CCN(CCOCCOCCOCCOCC=O)CC1,PEG,22,7,14,1222.547,No,,5P9J,"8E8",30807093,2,Yes,,Reviewed,Q06187,Yes,No,No,No,16,252.97000000000006
+586,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(CCCC(=O)N3CCC[C@@H](n4nc(-c5ccc(-c6ccccc6)cc5)c5c(N)ncnc54)C3)CC2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Active,Yes,THP-1,5.3227000000000135,,Daniel Zaidman,~ 200 nM,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1,Iap,,,other,17,5,,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,CCN1CCN(CCOCCOCCOCCOCC=O)CC1,PEG,23,7,15,1224.5629999999999,No,,5P9J,"8E8",30807093,3,Yes,,Reviewed,Q06187,Yes,No,No,No,16,252.97000000000006
+587,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)/C=C/CN2CCN(CCNC(=O)CCCCn3cc(COCCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)nn3)CC2)C1,Inactive,No,Ramos,4.089700000000003,covalent,Daniel Zaidman,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,18,4,,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,CN1CCN(CCNC(=O)CCCCn2cc(COCCC=O)nn2)CC1,Other,27,9,13,1076.2329999999995,CSK and LYN,,5P9J,"8E8",30807093,4,Yes,,Reviewed,Q06187,No,No,No,No,24,270.25999999999993
+588,Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCCNC(=O)CCCCn2cc(COCCC(=O)Nc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)nn2)C1,Active,No,Ramos,4.696100000000002,,Daniel Zaidman,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,,,Ibrutinib,C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1,CCNC(=O)CCCCn1cc(COCCC=O)nn1,Other,20,7,11,966.0729999999994,"CSK, LYN, and LAT2",,5P9J,"8E8",30807093,5,Yes,,Reviewed,Q06187,No,No,No,No,24,263.78
+589,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCCOC(=O)NC(Nc2ncccn2)C(Cl)(Cl)Cl)C(C)(C)C)cc1,Active,Yes,"MCF-7, U2OS, MDA-MB-231, MDA-MB-435, Flag-Cdc20, MDA-MB-231, 22Rv1, LNCaP",3.9215200000000072,EC50 of PROTAC is 2.6 uM for MDA-MB-231 and 1.99 uM for MDA-MB-435,Daniel Zaidman,1.6 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,6,,,Apcin,Cc1ncc([N+](=O)[O-])n1CCOC(=O)NC(Nc1ncccn1)C(Cl)(Cl)Cl,CNC(=O)CCOCCOCCOCCOCCOCCC=O,PEG,23,8,18,1075.5109999999993,No,,4N14,WR7,31669221,CP5V,No,,Reviewed,Q12834,Yes,No,No,Yes,10,263.0199999999999
+590,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,Hella,4.009520000000007,Engagment was tested in-vitro,"Daniel Zaidman, Yangwode Jing",,32 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCC=O,PEG,12,4,8,953.1759999999998,No,,5EU1,5SW,30540463,5,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,Yes,No,"4,16",189.92000000000002
+591,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,Hella,4.042720000000011,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCOCC=O,PEG,18,6,14,1041.2820000000002,No,,5EU1,5SW,30540463,6,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",208.38
+592,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Active,No,Hella,4.059320000000011,,"Daniel Zaidman, Yangwode Jing",,46 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,18,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCOCCOCC=O,PEG,21,7,17,1085.3349999999996,No,,5EU1,5SW,30540463,22,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",217.61
+593,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCCCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Active,No,Hella,5.179820000000008,,"Daniel Zaidman, Yangwode Jing",,20 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCCCCOCCOCC=O,Alkane,15,4,11,995.257,No,,5EU1,5SW,30540463,23,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",189.92000000000002
+594,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,Hella,4.026120000000009,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCC=O,PEG,15,5,11,997.2289999999999,No,,5EU1,5SW,30540463,24,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",199.15000000000003
+595,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(C(=O)COCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1,Inactive,No,Hella,3.5527200000000096,,"Daniel Zaidman, Yangwode Jing",,5 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)C(=O)COCCOCCOCC=O,PEG,16,6,10,1011.2119999999998,No,,5EU1,5SW,30540463,25,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",216.22000000000003
+596,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,Hella,4.890420000000005,Engagment was tested in-vitro,"Daniel Zaidman, Yangwode Jing",560 nM,10 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCO,PEG,12,4,8,1041.257,No,,5EU1,5SW,30540463,26,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,Yes,No,"4,16",199.15
+597,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)CC1,Active,No,Hella,4.692100000000006,,"Daniel Zaidman, Yangwode Jing",,12 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCO,PEG,12,4,8,1048.2769999999998,No,,5EU1,5SW,30540463,27,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",222.94
+598,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(C)=O)C(C)(C)C)CC1,Inactive,No,Hella,4.408220000000005,,"Daniel Zaidman, Yangwode Jing",,5 %,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,VHL,,,aliphatic_CC,16,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCO,PEG,12,4,8,997.2289999999998,No,,5EU1,5SW,30540463,28,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",199.15
+599,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,Hella,4.9236200000000085,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,18,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCOCCO,PEG,18,6,14,1129.3629999999998,No,,5EU1,5SW,30540463,29,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",217.61
+600,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)CC1,Inactive,No,Hella,4.725300000000008,,"Daniel Zaidman, Yangwode Jing",,11 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,19,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCOCCO,PEG,18,6,14,1136.3829999999996,No,,5EU1,5SW,30540463,30,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",241.4
+601,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(C)=O)C(C)(C)C)CC1,Inactive,No,Hella,4.441420000000008,,"Daniel Zaidman, Yangwode Jing",,2 %,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C,VHL,,,aliphatic_CC,18,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCOCCO,PEG,18,6,14,1085.3349999999996,No,,5EU1,5SW,30540463,31,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"4,16",217.61
+602,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",4.873820000000006,,"Daniel Zaidman, Yangwode Jing",,92 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCO,PEG,9,3,5,997.2039999999997,No,,5EU1,5SW,30540463,46,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",189.92000000000002
+603,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CCN(CCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",4.873820000000006,,"Daniel Zaidman, Yangwode Jing",,97 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,15,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCO,PEG,9,3,5,997.2039999999997,No,,5EU1,5SW,30540463,47,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",189.92000000000002
+604,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CCN(CCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",4.890420000000005,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,3,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CN(C)CCOCCOCCO,PEG,12,4,8,1041.257,No,,5F1H,5U6,30540463,48,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",199.15
+605,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",4.907020000000008,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,17,3,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CN(C)CCOCCOCCOCCO,PEG,15,5,11,1085.3099999999997,No,,5F1H,5U6,30540463,49,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",208.38000000000002
+606,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CCN(CCOCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",4.907020000000008,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,17,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCOCCOCCOCCO,PEG,15,5,11,1085.3099999999997,No,,5EU1,5SW,30540463,50,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",208.38000000000002
+607,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCCCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,Yes,"Hella, RI-1, EOL-1, A-204",6.027520000000005,DC50 is 1.76 nM and 4.5 nM,"Daniel Zaidman, Yangwode Jing",< 4.5 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,14,3,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CN(C)CCCCCO,Alkane,9,2,5,995.2319999999997,No,,5F1H,5U6,30540463,51 (VZ185),Yes,28418626,Reviewed,"Q9H8M2, Q9NPI1",Yes,Yes,Yes,Yes,"2,4",180.69
+608,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CCN(CCCCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",6.027520000000005,,"Daniel Zaidman, Yangwode Jing",,35 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,14,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCCCCO,Alkane,9,2,5,995.2319999999997,No,,5EU1,5SW,30540463,52,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",180.69
+609,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCCCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Active,No,"Hella, RI-1",6.044120000000006,,"Daniel Zaidman, Yangwode Jing",,17 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CN(C)CCCCCOCCO,Alkane,12,3,8,1039.2849999999999,No,,5EU1,5SW,30540463,53,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",189.92000000000002
+610,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CCN(CCCCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1,Inactive,No,"Hella, RI-1",6.044120000000006,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CN(C)CCCCCOCCO,Alkane,12,3,8,1039.2849999999999,No,,5F1H,5U6,30540463,54,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",189.92000000000002
+611,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CC(NC(=O)COCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.056620000000003,,"Daniel Zaidman, Yangwode Jing",,71 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,4,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CNC(=O)COCCO,PEG,9,4,4,997.1599999999997,No,,5EU1,5SW,30540463,55,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",215.77999999999997
+612,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CC(NC(=O)COCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.056620000000003,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,4,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CNC(=O)COCCO,PEG,9,4,4,997.1599999999997,No,,5F1H,5U6,30540463,56,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",215.77999999999997
+613,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CC(NC(=O)COCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.073220000000005,,"Daniel Zaidman, Yangwode Jing",,47 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CNC(=O)COCCOCCO,PEG,12,5,7,1041.2129999999997,No,,5EU1,5SW,30540463,57,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",225.01
+614,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CC(NC(=O)COCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.073220000000005,,"Daniel Zaidman, Yangwode Jing",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CNC(=O)COCCOCCO,PEG,12,5,7,1041.2129999999997,No,,5F1H,5U6,30540463,58,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",225.01
+615,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CC(NC(=O)COCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.089820000000008,,"Daniel Zaidman, Yangwode Jing",,2 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,4,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CNC(=O)COCCOCCOCCO,PEG,15,6,10,1085.2659999999994,No,,5EU1,5SW,30540463,59,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",234.23999999999998
+616,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CC(NC(=O)COCCOCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",4.089820000000008,,"Daniel Zaidman, Yangwode Jing",,15 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,4,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CNC(=O)COCCOCCOCCO,PEG,15,6,10,1085.2659999999994,No,,5F1H,5U6,30540463,60,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",234.23999999999998
+617,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CC(NC(=O)CCCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",5.210320000000005,,"Daniel Zaidman, Yangwode Jing",,75 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,14,4,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CNC(=O)CCCCO,Alkane,9,3,4,995.1879999999998,No,,5EU1,5SW,30540463,61,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",206.54999999999998
+618,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CC(NC(=O)CCCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",5.210320000000005,,"Daniel Zaidman, Yangwode Jing",,46 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,14,4,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CNC(=O)CCCCO,Alkane,9,3,4,995.1879999999998,No,,5F1H,5U6,30540463,62,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",206.54999999999998
+619,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CC(NC(=O)CCCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",5.226920000000005,,"Daniel Zaidman, Yangwode Jing",,69 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,4,,,1a,COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C,CNC(=O)CCCCOCCO,non-PEG polyether,12,4,7,1039.2409999999998,No,,5EU1,5SW,30540463,63,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",215.77999999999997
+620,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN1CC(NC(=O)CCCCOCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)C1,Active,No,"Hella, RI-1",5.226920000000005,,"Daniel Zaidman, Yangwode Jing",,3 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,4,,,1b,COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C,CNC(=O)CCCCOCCO,non-PEG polyether,12,4,7,1039.2409999999998,No,,5F1H,5U6,30540463,64,No,28418626,Reviewed,"Q9H8M2, Q9NPI1",No,No,No,No,"2,4",215.77999999999997
+621,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Active,Yes,"MM1S, HEK293T, CRBNY384A/W386A",0.04620000000000346,,"Daniel Zaidman, Yangwode Jing",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,12,4,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCOCCOCC,PEG,8,2,5,660.6400000000003,"IKZF1, IKZF3",,4CI3,Y70,30118587,15a,Yes,,Reviewed,Q96SW2,Yes,Yes,No,Yes,16,209.61999999999998
+622,O=C1CCC(N2C(=O)c3cccc(NCCCOCCOCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Active,No,MM1S,0.8264000000000018,,"Daniel Zaidman, Yangwode Jing",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,12,4,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCOCCOCCC,non-PEG polyether,10,2,7,688.6940000000003,IKZF1,,4CI3,Y70,30118587,15b,No,,Reviewed,Q96SW2,No,No,No,No,16,209.61999999999998
+623,O=C1CCC(N2C(=O)c3cccc(NCCCOCCCCOCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Active,No,MM1S,1.6066000000000018,,"Daniel Zaidman, Yangwode Jing",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,12,4,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCOCCCCOCCC,non-PEG polyether,12,2,9,716.7480000000002,IKZF1,,4CI3,Y70,30118587,15c,No,,Reviewed,Q96SW2,No,No,No,No,16,209.61999999999998
+624,O=C1CCC(N2C(=O)c3cccc(NCCCOCCOCCOCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Active,No,MM1S,0.8430000000000031,,"Daniel Zaidman, Yangwode Jing",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,13,4,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCOCCOCCOCCC,non-PEG polyether,13,3,10,732.7470000000002,IKZF1,,4CI3,Y70,30118587,15d,No,,Reviewed,Q96SW2,No,No,No,No,16,218.85
+625,O=C1CCC(N2C(=O)c3cccc(NCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Active,No,MM1S,0.02960000000000218,,"Daniel Zaidman, Yangwode Jing",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,11,4,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCOCC,PEG,5,1,2,616.5870000000002,IKZF1,,4CI3,Y70,30118587,15e,No,,Reviewed,Q96SW2,No,No,No,No,16,200.39
+626,O=C1CCC(N2C(=O)c3cccc(OCCOCCOCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3C2=O)C(=O)N1,Inactive,No,MM1S,-0.01999999999999702,,"Daniel Zaidman, Yangwode Jing",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_O,12,2,,,Thalidomide,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,OCCOCCOCCO,PEG,10,4,7,662.6080000000003,No,,4CI1,EF2,30118587,18,No,,Reviewed,Q96SW2,No,No,No,No,16,204.01999999999998
+627,O=C1CCC(N2C(=O)c3ccc(C(=O)NCCOCCOCCNC(=O)c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3C2=O)C(=O)N1,Inactive,No,MM1S,-1.3179999999999932,,"Daniel Zaidman, Yangwode Jing",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_C,12,4,,,Thalidomide,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,O=CNCCOCCOCCNC=O,PEG,14,6,11,716.6600000000002,No,,4CI1,EF2,30118587,19,No,,Reviewed,Q96SW2,No,No,No,No,16,243.76
+628,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.724300000000005,,Daniel Zaidman,2.63 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCC,Other,4,0,0,1130.1120000000003,No,,6NUQ,KQV,31747516,12,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+629,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.114400000000006,,Daniel Zaidman,0.26 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCC,Other,5,0,1,1144.1390000000004,No,,6NUQ,KQV,31747516,13,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+630,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,Yes,"Molm-16, SU-DHL-1",4.504500000000006,EC50 of PROTAC is 10nM-35nM,Daniel Zaidman,0.06 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,< 35 nM,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1158.1660000000004,No,,6NUQ,KQV,31747516,14 (SD-36),Yes,31715132,Reviewed,P40763,Yes,No,No,No,"4,16",310.80999999999995
+631,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.894600000000006,,Daniel Zaidman,0.09 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCCC,Other,7,0,3,1172.1930000000004,No,,6NUQ,KQV,31747516,15,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+632,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",5.674800000000006,,Daniel Zaidman,0.15 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCCCCC,Other,9,0,5,1200.2470000000003,No,,6NUQ,KQV,31747516,16,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+633,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(CCCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.977900000000005,,Daniel Zaidman,0.65 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amide_to_amine,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1144.1830000000004,No,,6NUQ,KQV,31747516,17,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",293.7399999999999
+634,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)OCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.334300000000006,,Daniel Zaidman,0.24 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,11,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCCO,Other,7,1,3,1160.1380000000004,No,,6NUQ,KQV,31747516,18,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",320.0399999999999
+635,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)NCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.907300000000009,,Daniel Zaidman,0.05 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,9,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCCN,Other,7,1,3,1159.1540000000005,No,,6NUQ,KQV,31747516,19,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",322.84
+636,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)c3cnn(CCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.8445000000000062,,Daniel Zaidman,0.18 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCn(-c)nc,Other,9,2,3,1196.1750000000002,No,,6NUQ,KQV,31747516,20,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",328.62999999999994
+637,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCn3cc(C#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cn3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.5790000000000077,,Daniel Zaidman,0.25 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#Cc1cnn(CC)c1,Other,9,2,1,1196.1750000000004,No,,6NUQ,KQV,31747516,21,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",328.63
+638,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)N3CCC(CCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.639600000000007,,Daniel Zaidman,0.18 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCC1CCNCC1,Other,10,1,2,1199.2190000000003,No,,6NUQ,KQV,31747516,22,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",314.0499999999999
+639,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCN3CCC(C#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.6561000000000092,,Daniel Zaidman,2.47 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CC1CCN(C)CC1,Other,9,1,0,1199.2190000000003,No,,6NUQ,KQV,31747516,23,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",314.0499999999999
+640,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CC(=O)N3CCC(C#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",3.1827000000000076,,Daniel Zaidman,0.38 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CC1CCN(C=O)CC1,Other,10,2,1,1213.2020000000002,No,,6NUQ,KQV,31747516,24,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",331.11999999999995
+641,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCCc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",5.085600000000007,,Daniel Zaidman,0.16 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,CCCCCC,Alkane,6,0,3,1162.1980000000005,No,,6NUQ,KQV,31747516,25,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+642,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCCNc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.564900000000007,,Daniel Zaidman,0.09 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,9,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,CCCCC,Alkane,5,0,2,1163.1860000000004,No,,6NUQ,KQV,31747516,26,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",322.84
+643,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.144700000000006,,Daniel Zaidman,3.54 uM,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,11,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1172.1490000000003,No,,6NUQ,KQV,31747516,27,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",327.87999999999994
+644,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.5045000000000055,,Daniel Zaidman,0.41 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1158.1660000000004,No,,6NUQ,KQV,31747516,28,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+645,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Active,No,"Molm-16, SU-DHL-1",4.504500000000006,,Daniel Zaidman,0.36 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1158.1660000000004,No,,6NUQ,KQV,31747516,29,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+646,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NCc1ccccc1,Active,No,"Molm-16, SU-DHL-1",2.915100000000005,,Daniel Zaidman,0.22 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109 analog,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCc3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(C(F)(F)P(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1082.0680000000004,No,,6NUQ,KQV,31747516,30,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+647,CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12,Active,No,"Molm-16, SU-DHL-1",1.3447000000000042,,Daniel Zaidman,0.64 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109 analog,CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CC[C@@H]2CCN(C(C)=O)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N12,C#CCCCC,Other,6,0,2,1005.9700000000003,No,,6NUQ,KQV,31747516,31,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.81
+648,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(OP(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Inactive,No,"Molm-16, SU-DHL-1",3.749000000000006,,Daniel Zaidman,> 10 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,8,,,SI-109 analog,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(OP(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1124.1580000000004,No,,6NUQ,KQV,31747516,32,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",320.0399999999999
+649,NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCCCCC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C[C@H](NC(=O)c3cc4cc(CP(=O)(O)O)ccc4[nH]3)C(=O)N12)C(=O)NC(c1ccccc1)c1ccccc1,Inactive,No,"Molm-16, SU-DHL-1",3.9552000000000076,,Daniel Zaidman,> 10 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,8,,,SI-109 analog,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)c2cc3cc(CP(=O)(O)O)ccc3[nH]2)C1,C#CCCCC,Other,6,0,2,1122.1860000000004,No,,6NUQ,KQV,31747516,33,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",310.80999999999995
+650,C/C(=C\C(=O)N[C@H]1CN(C(=O)CCCCCC#Cc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O)c1ccc(C(F)(F)P(=O)(O)O)cc1,Active,No,"Molm-16, SU-DHL-1",4.812900000000009,,Daniel Zaidman,4.45 uM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,7,,,SI-109 analog,CC(=O)N1CC[C@H]2CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c3ccccc3)c3ccccc3)N2C(=O)[C@@H](NC(=O)/C=C(\C)c2ccc(C(F)(F)P(=O)(O)O)cc2)C1,C#CCCCC,Other,6,0,2,1159.1939999999997,No,,6NUQ,KQV,31747516,34,No,31715132,Reviewed,P40763,No,No,No,No,"4,16",295.02
+651,O=C1CCC(N2C(=O)c3cccc(NCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,6.442900000000005,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCC,Alkane,3,0,0,908.8150000000002,No,,5TRF,7HC,30525597,1,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+652,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,5.695900000000004,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,97 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCOCCOC,PEG,7,2,4,968.8669999999998,No,,5TRF,7HC,30525597,2,No,,Reviewed,Q00987,No,No,No,No,2,213.36999999999998
+653,O=C1CCC(N2Cc3c(NC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)cccc3C2=O)C(=O)N1,Inactive,No,RS4;11,6.4329000000000045,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,10 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,7,5,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,None,Other,0,0,0,823.7090000000003,No,,5TRF,7HC,30525597,3,No,,Reviewed,Q00987,No,No,No,No,2,165.81
+654,O=C1CCC(N2C(=O)c3cccc(NCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,5.662700000000003,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,60 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,C,Alkane,1,0,0,880.7610000000002,No,,5TRF,7HC,30525597,4,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+655,O=C1CCC(N2C(=O)c3cccc(NCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,6.052800000000005,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CC,Alkane,2,0,0,894.7880000000001,No,,5TRF,7HC,30525597,5,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+656,O=C1CCC(N2C(=O)c3cccc(NCCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,6.8330000000000055,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,80 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCCC,Alkane,4,0,1,922.8420000000001,No,,5TRF,7HC,30525597,6,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+657,O=C1CCC(N2C(=O)c3cccc(NCCCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,7.223100000000006,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,40 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCCCC,Alkane,5,0,2,936.869,No,,5TRF,7HC,30525597,7,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+658,O=C1CCC(N2C(=O)c3cccc(NCCCCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Inactive,No,RS4;11,7.613200000000006,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,30 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCCCCC,Alkane,6,0,3,950.896,No,,5TRF,7HC,30525597,8,No,,Reviewed,Q00987,No,No,No,No,2,194.91
+659,O=C1CCC(N2C(=O)c3cccc(NCCOCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,5.679300000000005,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,10,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCOC,PEG,4,1,1,924.8140000000001,No,,5TRF,7HC,30525597,9,No,,Reviewed,Q00987,No,No,No,No,2,204.14
+660,O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)c3C2=O)C(=O)N1,Active,No,RS4;11,5.712500000000004,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,6,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCOCCOCCOC,PEG,10,3,7,1012.9199999999997,No,,5TRF,7HC,30525597,10,No,,Reviewed,Q00987,No,No,No,No,2,222.6
+661,O=C1CCC(N2Cc3c(CCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)cccc3C2=O)C(=O)N1,Active,No,"RS4;11, MV4;11",7.323400000000007,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,98 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,7,5,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,CCCC,Alkane,4,0,1,893.8440000000002,No,,5TRF,7HC,30525597,13 (MD-222),No,,Reviewed,Q00987,No,No,No,No,2,165.81
+662,O=C1CCC(N2Cc3c(C#CCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)cccc3C2=O)C(=O)N1,Active,Yes,"RS4;11, MV4;11",6.7423000000000055,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,99 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,7,5,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,C#CCC,Other,4,0,0,889.8120000000002,No,,5TRF,7HC,30525597,14 (MD-224),No,,Reviewed,Q00987,Yes,No,No,Yes,2,165.81
+663,O=C1CCC(N2Cc3cc(C#CCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)ccc3C2=O)C(=O)N1,Active,No,RS4;11,6.7423000000000055,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,80 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,7,5,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,C#CCC,Other,4,0,0,889.8120000000001,No,,5TRF,7HC,30525597,16,No,,Reviewed,Q00987,No,No,No,No,2,165.81
+664,O=C1CCC(N2Cc3ccc(C#CCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)cc3C2=O)C(=O)N1,Active,No,RS4;11,6.742300000000005,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,80 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,7,5,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,C#CCC,Other,4,0,0,889.8120000000001,No,,5TRF,7HC,30525597,17,No,,Reviewed,Q00987,No,No,No,No,2,165.81
+665,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCNC(=O)c2ccc(NC(=O)[C@@H]3NC4(CCCCC4)[C@@]4(C(=O)Nc5cc(Cl)ccc54)[C@H]3c3cccc(Cl)c3F)cc2)C(C)(C)C)cc1,Inactive,No,RS4;11,7.830320000000009,EC50 of ligand and PROTAC was measured in RS4;11 cell line.,Daniel Zaidman,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,13,7,2.7 nM,,MI-1242,CNC(=O)c1ccc(NC(=O)[C@@H]2NC3(CCCCC3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)cc1,COCCOCCOCCC=O,PEG,12,4,9,1198.2559999999992,No,,5TRF,7HC,30525597,20,No,,Reviewed,Q00987,No,No,No,No,2,238.64999999999998
+666,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,5.993800000000006,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,35 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CC=O,Alkane,3,1,0,935.039,No,,,,30629437,8,No,,Reviewed,P10275,No,No,No,No,6,188.07
+667,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,6.383900000000006,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,33 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCC=O,Alkane,4,1,1,949.0659999999999,No,,,,30629437,9,No,,Reviewed,P10275,No,No,No,No,6,188.07
+668,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Inactive,No,LNCaP,6.774000000000006,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,25 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCC=O,Alkane,5,1,2,963.093,No,,,,30629437,10,No,,Reviewed,P10275,No,No,No,No,6,188.07
+669,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Inactive,No,LNCaP,7.1641000000000075,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,29 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCC=O,Alkane,6,1,3,977.12,No,,,,30629437,11,No,,Reviewed,P10275,No,No,No,No,6,188.07
+670,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,7.554200000000007,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,84 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCC=O,Alkane,7,1,4,991.1469999999999,No,,,,30629437,12,No,,Reviewed,P10275,No,No,No,No,6,188.07
+671,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,7.944300000000007,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,65 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCC=O,Alkane,8,1,5,1005.174,No,,,,30629437,13,No,,Reviewed,P10275,No,No,No,No,6,188.07
+672,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,8.334400000000006,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,87 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCCC=O,Alkane,9,1,6,1019.201,No,,,,30629437,14,No,,Reviewed,P10275,No,No,No,No,6,188.07
+673,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,8.724500000000004,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,88 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCCCC=O,Alkane,10,1,7,1033.228,No,,,,30629437,15,No,,Reviewed,P10275,No,No,No,No,6,188.07
+674,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,9.114600000000001,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,86 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCCCCC=O,Alkane,11,1,8,1047.255,No,,,,30629437,16,No,,Reviewed,P10275,No,No,No,No,6,188.07
+675,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,9.5047,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,75 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,10,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCCCCCC=O,Alkane,12,1,9,1061.282,No,,,,30629437,17,No,,Reviewed,P10275,No,No,No,No,6,188.07
+676,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)C(C)(C)C)cc1,Active,No,LNCaP,6.0270000000000055,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,40 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,12,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,COCCOCCC=O,PEG,9,3,6,1023.145,No,,,,30629437,18,No,,Reviewed,P10275,No,No,No,No,6,206.53
+677,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCc2ccc(C#Cc3ccc(N4C(=S)N(c5ccc(C#N)c(C(F)(F)F)c5)C(=O)C4(C)C)cc3)cn2)C(C)(C)C)cc1,Active,No,LNCaP,9.022600000000002,,Daniel Zaidman,,96 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,10,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(CCCCCCC=O)nc1,Other,15,2,7,1031.24,No,,,,30629437,19,No,,Reviewed,P10275,No,No,No,No,6,171.85999999999996
+678,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Active,No,LNCaP,7.431800000000008,,Daniel Zaidman,,80 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(CCCC=O)CC2)nc1,Other,18,4,5,1073.2809999999995,No,,,,30629437,20,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+679,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Active,No,LNCaP,7.99280000000001,,Daniel Zaidman,,92 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(CCCC=O)CC2)nc1,Other,18,4,5,1087.3079999999993,No,,,,30629437,21,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+680,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Active,No,LNCaP,8.382900000000006,,Daniel Zaidman,,89 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(CCCCC=O)CC2)nc1,Other,19,4,6,1101.3349999999994,No,,,,30629437,22,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+681,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Active,No,LNCaP,7.602700000000009,,Daniel Zaidman,,78 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(CCC=O)CC2)nc1,Other,17,4,4,1073.2809999999995,No,,,,30629437,23,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+682,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Active,No,LNCaP,7.212600000000009,,Daniel Zaidman,,31 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,12,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(CC=O)CC2)nc1,Other,16,4,3,1059.2539999999997,No,,,,30629437,24,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+683,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)N2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)C(C)(C)C)cc1,Inactive,No,LNCaP,7.806000000000009,,Daniel Zaidman,,12 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,11,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N2CCN(C=O)CC2)nc1,Other,15,4,2,1045.2269999999996,No,,,,30629437,25,No,,Reviewed,P10275,No,No,No,No,6,178.33999999999997
+684,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)NCCCCCCCCCNC(=O)c2ccc(N3C(=S)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)C3(C)C)cc2F)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,9.587119999999999,"EC50 of ligand is LNCaP 25 nM, VCaP 87.4 nM, 22RV1 > 10 uM",Daniel Zaidman,,87 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,aliphatic_CC,12,4,,,Enzalutamide,CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCCCCCC,Alkane,7,0,4,1114.302,No,,,,30629437,26,No,,Reviewed,P10275,No,No,No,No,6,214.09999999999997
+685,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)NCCCN2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,8.294420000000008,,Daniel Zaidman,,94 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,14,3,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CCN1CCN(c2ccc(C)cn2)CC1,Other,15,3,2,1154.3549999999996,No,,,,30629437,27,No,,Reviewed,P10275,No,No,No,No,6,204.36999999999995
+686,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCN(c3ccc(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)cn3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,8.314720000000007,,Daniel Zaidman,,93 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,13,2,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,Cc1ccc(N(C)C)nc1,Other,10,2,1,1097.2589999999996,No,,,,30629437,28,No,,Reviewed,P10275,No,No,No,No,6,192.33999999999992
+687,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(N5C(=S)N(c6ccc(C#N)c(C(F)(F)F)c6)C(=O)C5(C)C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,8.925820000000005,,Daniel Zaidman,,97 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,12,2,,,Enzalutamide (-F analog),CNC(=O)c1ccc(N2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)C2(C)C)cc1F,CC1CCN(C(C)C)CC1,Other,10,1,1,1102.3189999999995,No,,,,30629437,29,No,,Reviewed,P10275,No,No,No,No,6,179.44999999999993
+688,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(N5C(=S)N(c6cnc(C#N)c(C(F)(F)F)c6)C(=O)C56CCC6)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,8.464920000000008,,Daniel Zaidman,,95 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,13,2,,,Enzalutamide (analog),Cc1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1,CC1CCN(C(C)C)CC1,Other,10,1,1,1115.3179999999993,No,,,,30629437,30,No,,Reviewed,P10275,No,No,No,No,6,192.33999999999997
+689,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(S(=O)CC(C)(O)C(=O)Nc5ccc(C#N)c(C(F)(F)F)c5)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,7.50642000000001,,Daniel Zaidman,,35 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,13,4,,,Enzalutamide (analog),Cc1ccc(S(=O)CC(C)(O)C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1,CC1CCN(C(C)C)CC1,Other,10,1,1,1109.3069999999996,No,,,,30629437,31,No,,Reviewed,P10275,No,No,No,No,6,222.29999999999995
+690,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,9.255720000000004,,Daniel Zaidman,,99 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,12,3,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CC1CCN(C(C)C)CC1,Other,10,1,1,1095.8079999999995,No,,,,30629437,32,No,,Reviewed,P10275,No,No,No,No,6,194.22999999999996
+691,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(Cc5c(C)nn(-c6ccc(C#N)c(Cl)c6)c5C)cc4)CC3)CC2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,9.037060000000006,,Daniel Zaidman,,93 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,12,2,,,Enzalutamide (analog),Cc1ccc(Cc2c(C)nn(-c3ccc(C#N)c(Cl)c3)c2C)cc1,CC1CCN(C(C)C)CC1,Other,10,1,1,1034.7279999999996,No,,,,30629437,33,No,,Reviewed,P10275,No,No,No,No,6,173.71999999999997
+692,Cc1ncsc1-c1ccc([C@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,Active,Yes,"LNCaP, VCaP, and 22Rv",8.552500000000006,"DC50 is 0.86nM in LNCaP, 0.76 in VCaP and 10.4 nM at 1uM in 22Rv1. EC50 in cells is 0.25nM for LNCaP, 0.34 nM for VCaP, 183nM for 22Rv1.",Daniel Zaidman,< 10.4 nM,> 95 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1,VHL,,,other,11,4,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CC1CCN(C2CCN(C=O)CC2)CC1,Other,15,3,2,1129.8409999999992,No,,,,30629437,34 (ARD-69),No,,Reviewed,P10275,Yes,Yes,No,Yes,"6,24",197.29999999999998
+693,Cc1ncsc1-c1ccc([C@H](CC(=O)N2CCC(N3CCC(C#Cc4ccc(C(=O)N[C@H]5C(C)(C)[C@H](Oc6ccc(C#N)c(Cl)c6)C5(C)C)cc4)CC3)CC2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1,Active,No,LNCaP,8.354180000000007,,Daniel Zaidman,,100 %,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1,VHL,,,other,12,4,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CC1CCN(C2CCN(C=O)CC2)CC1,Other,15,3,2,1136.8609999999992,No,,,,30629437,35,No,,Reviewed,P10275,No,No,No,No,6,221.08999999999997
+694,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CC(=O)N1CCC(N2CCC(C#Cc3ccc(C(=O)N[C@H]4C(C)(C)[C@H](Oc5ccc(C#N)c(Cl)c5)C4(C)C)cc3)CC2)CC1)c1ccc(-c2scnc2C)cc1)C(C)(C)C,Active,No,LNCaP,8.07030000000001,,Daniel Zaidman,,99 %,CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)C,VHL,,,other,11,4,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CC1CCN(C2CCN(C=O)CC2)CC1,Other,15,3,2,1085.8129999999992,No,,,,30629437,36,No,,Reviewed,P10275,No,No,No,No,6,197.29999999999995
+695,Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(=O)NCCCCCCCCCNC(=O)c2ccc(C(=O)N[C@H]3C(C)(C)[C@H](Oc4ccc(C#N)c(Cl)c4)C3(C)C)cc2)c2ccc(-c3scnc3C)cc2)C(C)C)on1,Active,No,LNCaP,9.777919999999998,,Daniel Zaidman,,96 %,CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(-c2scnc2C)cc1,VHL,,,other,12,5,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CCCCCCCCN,Alkane,9,1,6,1089.801,No,,,,30629437,39,No,,Reviewed,P10275,No,No,No,No,6,228.87999999999994
+696,CC1(C)[C@H](NC(=O)c2ccc(C(=O)NCCCCCCCCCCc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,Inactive,No,LNCaP,7.318180000000008,,Daniel Zaidman,,20 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,8,3,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CCCCCCCCCCN,Alkane,11,1,8,822.4030000000001,No,,,,30629437,40,No,,Reviewed,P10275,No,No,No,No,6,174.76999999999998
+697,CC1(C)[C@H](NC(=O)c2ccc(C#CC3CCN(C4CCN(c5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)cc2)C(C)(C)[C@H]1Oc1ccc(C#N)c(Cl)c1,Inactive,No,LNCaP,5.957380000000006,,Daniel Zaidman,,25 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,9,2,,,Enzalutamide (analog),Cc1ccc(C(=O)N[C@H]2C(C)(C)[C@H](Oc3ccc(C#N)c(Cl)c3)C2(C)C)cc1,CCC(CC)N1CCC(C)CC1,Other,12,1,3,829.3979999999998,No,,,,30629437,41,No,,Reviewed,P10275,No,No,No,No,6,152.14999999999998
+698,C=CC(=O)N1CCN(c2nc(NCCC(=O)NCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.247400000000006,,Efrat Resnick,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,14,5,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCNC(=O)CCN,non-PEG polyether,15,6,10,936.3979999999999,No,,5V9O,91G,31883964,2,No,,Reviewed,P01116,No,No,No,No,16,224.73
+699,C=CC(=O)N1CCN(c2nc(NCCC(=O)NCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.280600000000008,,Efrat Resnick,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,16,5,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCOCCNC(=O)CCN,non-PEG polyether,21,8,16,1024.504,No,,5V9O,91G,31883964,3,No,,Reviewed,P01116,No,No,No,No,16,243.19000000000003
+700,C=CC(=O)N1CCN(c2nc(NCCCc3cn(CCOCCOCCOCCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)nn3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,5.258500000000006,,Efrat Resnick,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,16,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCCc1cn(CCOCCOCCOCCC(N)=O)nn1,non-PEG polyether,23,9,15,1032.531,No,,5V9O,91G,31883964,4,No,,Reviewed,P01116,No,No,No,No,16,235.56999999999996
+701,C=CC(=O)N1CCN(c2nc(NCCOCCOCCOCCc3cn(CCOCCOCCOCCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)nn3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.91820000000001,,Efrat Resnick,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,19,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCc1cn(CCOCCOCCOCCC(N)=O)nn1,non-PEG polyether,31,12,23,1150.663,No,,5V9O,91G,31883964,5,No,,Reviewed,P01116,No,No,No,No,16,263.26
+702,C=CC(=O)N1CCN(c2nc(NCCOCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.724600000000005,,Efrat Resnick,,7 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,14,3,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCO,PEG,13,5,10,910.356,No,,5V9O,91G,31883964,6,No,,Reviewed,P01116,No,No,No,No,16,202.05999999999997
+703,C=CC(=O)N1CCN(c2nc(NCCOCCOCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.741200000000006,,Efrat Resnick,,6 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,15,3,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCOCCO,PEG,16,6,13,954.4089999999999,No,,5V9O,91G,31883964,7,No,,Reviewed,P01116,No,No,No,No,16,211.29
+704,C=CC(=O)N1CCN(c2nc(NCCOCCOCCOCCOCCOCCOc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.757800000000006,,Efrat Resnick,,3 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,16,3,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCOCCOCCO,PEG,19,7,16,998.4619999999999,No,,5V9O,91G,31883964,8,No,,Reviewed,P01116,No,No,No,No,16,220.52
+705,C=CC(=O)N1CCN(c2nc(NCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.757700000000006,Engagment was tested in-vitro,Efrat Resnick,,19 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,14,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCOCCN,PEG,13,5,10,909.372,No,,5V9O,91G,31883964,9,No,,Reviewed,P01116,Yes,No,Yes,No,16,204.85999999999999
+706,C=CC(=O)N1CCN(c2nc(NCCCCCCCCCCCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,8.608900000000006,,Efrat Resnick,,1 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,11,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCCCCCCCCCCCN,Alkane,14,2,11,917.4830000000001,No,,5V9O,91G,31883964,10,No,,Reviewed,P01116,No,No,No,No,16,177.17
+707,C=CC(=O)N1CCN(c2nc(NCCCN(C)CCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,5.4199000000000055,Engagment was tested in-vitro,Efrat Resnick,,25 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,12,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,CN(CCCN)CCCN,Other,10,3,6,862.3629999999999,No,,5V9O,91G,31883964,11,No,,Reviewed,P01116,No,No,Yes,No,16,180.41
+708,C=CC(=O)N1CCN(c2nc(NCCN3CCN(CCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.325500000000005,,Efrat Resnick,,24 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,13,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCN1CCN(CCN)CC1,Other,12,4,4,889.3889999999998,No,,5V9O,91G,31883964,12,No,,Reviewed,P01116,No,No,No,No,16,183.65
+709,C=CC(=O)N1CCN(c2nc(NCCCN3CCN(CCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Active,Yes,GFP-KRASG12C reporter cell line in Flp-In 293,5.105700000000006,Engagment was tested in-vitro,Efrat Resnick,,32 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,13,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCCN1CCN(CCCN)CC1,Other,14,4,6,917.4429999999999,No,,5V9O,91G,31883964,13 (XY-4-88),Yes,,Reviewed,P01116,Yes,Yes,Yes,Yes,16,183.65
+710,C=CC(=O)N1CCN(c2nc(NCCCCN3CCN(CCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,5.885900000000007,,Efrat Resnick,,17 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,13,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCCCN1CCN(CCCCN)CC1,Other,16,4,8,945.4969999999998,No,,5V9O,91G,31883964,14,No,,Reviewed,P01116,No,No,No,No,16,183.65
+711,C=CC(=O)N1CCN(c2nc(NCCOCCCN3CCN(CCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.748800000000006,,Efrat Resnick,,10 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,15,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCCN1CCN(CCOCCN)CC1,Other,19,6,11,991.5219999999997,No,,5V9O,91G,31883964,15,No,,Reviewed,P01116,No,No,No,No,16,202.10999999999999
+712,C=CC(=O)N1CCN(c2nc(NCCOCCOCCNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Inactive,No,GFP-KRASG12C reporter cell line in Flp-In 293,4.741100000000003,,Efrat Resnick,,4 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,13,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCOCCOCCN,PEG,10,4,7,865.319,No,,5V9O,91G,31883964,16,No,,Reviewed,P01116,No,No,No,No,16,195.62999999999997
+713,C=CC(=O)N1CCN(c2nc(NCCCN3CCN(CCCNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,Active,No,GFP-KRASG12C reporter cell line in Flp-In 293,5.105700000000006,,Efrat Resnick,,35 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aryl_N,13,4,,,Compound 1,C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1,NCCCN1CCN(CCCN)CC1,Other,14,4,6,917.4429999999999,No,,5V9O,91G,31883964,17,No,,Reviewed,P01116,No,No,No,No,16,183.65
+714,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,HEK293T,4.471420000000002,,"Paul Gehrtz, Yangwode Jing",44.5 nM,97.1 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,11,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCCCC=O,Alkane,10,1,7,842.032,CNIH1 and LMBRD2,,4CI3,Y70,31873151,6a (TD158),Yes,,Reviewed,Q96SW2,No,Yes,Yes,Yes,24,207.20999999999998
+715,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,Yes,HEK293T,5.251620000000002,,"Paul Gehrtz, Yangwode Jing",20.4 nM,99.6 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,11,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCCCCCC=O,Alkane,12,1,9,870.086,No,,4CI3,Y70,31873151,6b (TD165),No,,Reviewed,Q96SW2,No,No,Yes,No,24,207.20999999999998
+716,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,HEK293T,3.6912200000000013,,"Paul Gehrtz, Yangwode Jing",100.6 nM,96.9 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,11,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CCCCCCC=O,Alkane,8,1,5,813.978,No,,4CI3,Y70,31873151,6d (TD-156),No,,Reviewed,Q96SW2,No,No,Yes,No,24,207.20999999999998
+717,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,HEK293T,4.367820000000004,,"Paul Gehrtz, Yangwode Jing",28.8 nM,98.4 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,12,6,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,CC(=O)NCCCCCCCCCCC=O,Alkane,16,3,11,927.1379999999999,No,,4CI3,Y70,31873151,6e (TD-759),No,,Reviewed,Q96SW2,Yes,No,Yes,No,24,236.30999999999997
+718,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,HEK293T,4.3347200000000035,,"Paul Gehrtz, Yangwode Jing",367.7 nM,82 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_ether,12,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,O=CCCCCCCCCCCNC(=O)CO,Alkane,17,4,12,928.122,No,,4CI3,Y70,31873151,6f (TD-760),No,,Reviewed,Q96SW2,No,No,Yes,No,24,233.50999999999996
+719,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1,Active,No,HEK293T,3.2178200000000006,,"Paul Gehrtz, Yangwode Jing",2546.1 nM,77.9 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_amide,11,5,,,Pomalidomide,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,O=CCCCCCC=O,Alkane,9,2,6,827.961,No,,4CI3,Y70,31873151,12 (TD-033),No,,Reviewed,Q96SW2,No,No,Yes,No,24,224.27999999999997
+720,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)c5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,Jurkat,7.820840000000009,,Daniel Zaidman,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCCCCC=O,Alkane,9,1,6,1016.3269999999995,No,,5L2I,LQQ,32184044,4,No,,Reviewed,"P11802, Q00534",No,No,No,Yes,24,207.88
+721,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)c5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,Jurkat,5.530040000000008,,Daniel Zaidman,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,18,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCC=O,PEG,12,4,9,1064.3239999999996,No,,5L2I,LQQ,32184044,5,No,,Reviewed,"P11802, Q00534",No,No,No,No,24,235.57
+722,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CC(=O)NCCOCCOCCOCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)N[C@@H](C)c5ccc(-c6scnc6C)cc5)C(C)(C)C)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,Jurkat,5.036340000000011,"inactive for CDK4, active for CDK6",Daniel Zaidman,,,Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,19,5,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CC(=O)NCCOCCOCCOCCC=O,PEG,17,6,12,1135.403,No,,5L2I,LQQ,32184044,6,No,,Reviewed,"P11802, Q00534",No,No,No,No,24,264.66999999999996
+723,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)COCCOCCOCCN2CCN(c3ccc(Nc4ncc5c(C)c(C(C)=O)c(=O)n(C6CCCC6)c5n4)nc3)CC2)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C,Active,No,Jurkat,3.8694200000000105,,Daniel Zaidman,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C,Iap,,,amine_to_methylamine,17,5,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCOCC=O,Alkane,12,4,9,1059.229999999999,No,,5L2I,LQQ,32184044,7,No,,Reviewed,"P11802, Q00534",No,No,No,Yes,24,243.57999999999996
+724,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)CCOCCOCCOCCNC(=O)CN2CCN(c3ccc(Nc4cc5c(cn4)c(C)c(C(C)=O)c(=O)n5C4CCCC4)nc3)CC2)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C,Inactive,No,Jurkat,3.980720000000013,,Daniel Zaidman,,,CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C,Iap,,,other,17,6,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CC(=O)NCCOCCOCCOCCC=O,PEG,17,6,12,1129.3209999999992,No,,5L2I,LQQ,32184044,9,No,,Reviewed,"P11802, Q00534",No,No,No,No,24,259.78999999999996
+725,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,Yes,Jurkat,3.0879200000000013,,Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,15,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCNC(C)=O,Alkane,8,2,3,831.9349999999996,No,,5L2I,LQQ,32184044,10,No,,Reviewed,"P11802, Q00534",No,No,No,Yes,24,220.93
+726,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(CCOCCOCCNC(=O)CNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cn3)nc2n(C2CCCC2)c1=O,Active,No,Jurkat,2.3409200000000023,,Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,17,4,,,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCOCCOCCNC(C)=O,PEG,12,4,7,891.9869999999995,No,,5L2I,LQQ,32184044,11,No,,Reviewed,"P11802, Q00534",No,No,No,No,24,239.39
+727,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C,Inactive,No,"MV4-11, Molm-13",2.8012999999999995,"EC50 of ligand is 0.370 uM for MV4- 11, 3.369 uM for Molm-13. EC50 of PROTAC is 1.648uM for MV4-11, >10uM for Molm-13",Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,10,4,49.5 nM,,compound 6,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cccc13)C(=O)N2C,CCNC(=O)CC,Alkane,7,2,2,738.779,No,,,,31767403,13,No,,Reviewed,"O60885, P25440",No,No,No,No,"1,2,4,6,16,24",200.39
+728,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C,Active,No,"MV4-11, Molm-13",3.1914000000000007,"EC50 of ligand is 0.370 uM for MV4- 11, 3.369 uM for Molm-13. EC50 of PROTAC is 0.025uM for MV4-11, 0.18uM for Molm-13",Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,10,4,49.5 nM,,compound 6,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cccc13)C(=O)N2C,CCCNC(=O)CC,Alkane,8,2,3,752.806,No,,,,31767403,14,No,,Reviewed,"O60885, P25440",No,No,No,No,"1,2,4,6,16,24",200.39
+729,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C,Active,Yes,Big sellection of cacer cell lines,3.581500000000001,"EC50 of ligand is 0.370 uM for MV4- 11, 3.369 uM for Molm-13. EC50 of PROTAC is 0.012uM for MV4-11, 0.052uM for Molm-13.",Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,10,4,49.5 nM,,compound 6,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cccc13)C(=O)N2C,CCCCNC(=O)CC,Alkane,9,2,4,766.8330000000001,No,,,,31767403,15,No,,Reviewed,"O60885, P25440",No,No,No,No,"1,2,4,6,16,24",200.39
+730,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C,Active,No,"MV4-11, Molm-13",3.9716000000000014,"EC50 of ligand is 0.370 uM for MV4- 11, 3.369 uM for Molm-13. EC50 of PROTAC is 0.032uM for MV4-11, 0.177uM for Molm-13.",Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,10,4,49.5 nM,,compound 6,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cccc13)C(=O)N2C,CCCCCNC(=O)CC,Alkane,10,2,5,780.86,No,,,,31767403,16,No,,Reviewed,"O60885, P25440",No,No,No,No,"1,2,4,6,16,24",200.39
+731,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(CCC(=O)NCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc13)C(=O)N2C,Inactive,No,"MV4-11, Molm-13",4.361700000000003,"EC50 of ligand is 0.370 uM for MV4- 11, 3.369 uM for Molm-13. EC50 of PROTAC is 3.429uM for MV4-11, >10uM for Molm-13.",Daniel Zaidman,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_C,10,4,49.5 nM,,compound 6,COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cccc13)C(=O)N2C,CCCCCCNC(=O)CC,Alkane,11,2,6,794.8870000000001,No,,,,31767403,17,No,,Reviewed,"O60885, P25440",No,No,No,No,"1,2,4,6,16,24",200.39
+732,ClC1=CC=C(C2=N[C@@H](CNC(C3=CC(F)=C(/N=N/C4=C(F)C=C(C(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)C=C4F)C(F)=C3)=O)C8=NN=C(C)N8C9=C2C(C)=C(C)S9)C=C1,Active,Yes,RAMOS,10.055979999999995,,"Shimrit Azulay, Daniel Zaidman",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,4,,,JQ1,O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C,NC(=O)c1cc(F)c(/N=N/c2c(F)cc(C=O)cc2F)c(F)c1,Other,23,5,4,1108.6449999999998,,,,,31660436,trans-photoPROTAC-1,No,,Reviewed,O15155,No,No,No,No,,208.51999999999998
+733,ClC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CNC(C5=CC(F)=C(C(F)=C5)/N=N\C6=C(C=C(C=C6F)C(N[C@H](C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C=C8)C9=C(N=CS9)C)=O)=O)C(C)(C)C)=O)F)=O,Inactive,No,RAMOS,10.055979999999998,,"Shimrit Azulay, Daniel Zaidman",,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,4,,,JQ1,O=C(C[C@H]1C2=NN=C(N2C3=C(C(C4=CC=C(C=C4)Cl)=N1)C(C)=C(S3)C)C)OC(C)(C)C,NC(=O)c1cc(F)c(/N=N\c2c(F)cc(C=O)cc2F)c(F)c1,Other,23,5,4,1108.6449999999993,,,,,31660436,cis-photoPROTAC-1,No,,Reviewed,O15155,No,No,No,No,,208.51999999999998
+736,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=C(CCC(NCCOCOCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C=C3)(=O)=O)C=C(C)C2=O,Active,No,A375,5.797440000000005,IC50 value of PROTAC tested with MEK1,"Shimrit Azulay, Daniel Zaidman",,,N[C@H](C(N1C[C@@H](C[C@H]1C(N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C,VHL,,,aryl_C,15,6,0.4 uM,0.1 uM,Compound 2,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=CC=C3)(=O)=O)C=C(C)C2=O,CCC(=O)NCCOCOCOCC=O,PEG,15,6,10,1173.1379999999995,,,,VRA,31804822,Compound 3,No,,Reviewed,"P36507, Q02750",No,No,No,Yes,16,248.61999999999995
+737,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=C(CCC(NCCOCOCOCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C=C3)(=O)=O)C=C(C)C2=O,Active,Yes,A375,5.771540000000005,IC50 value of PROTAC tested with MEK1,"Shimrit Azulay, Daniel Zaidman",,,N[C@H](C(N1C[C@@H](C[C@H]1C(N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C,VHL,,,aryl_C,16,6,0.4 uM,0.1 uM,Compound 2,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=CC=C3)(=O)=O)C=C(C)C2=O,CCC(=O)NCCOCOCOCOCC=O,PEG,17,7,12,1203.1639999999995,,,,VRA,31804822,Compound 4,No,,Reviewed,"P36507, Q02750",No,No,No,Yes,16,257.84999999999997
+738,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=C(OCC(NCCOCOCOCC(N[C@@H](C(C)(C)C)C(N4C[C@H](O)C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C=C3)(=O)=O)C=C(C)C2=O,Active,No,A375,5.243640000000004,IC50 value of PROTAC tested with MEK1,"Shimrit Azulay, Daniel Zaidman",,,N[C@H](C(N1C[C@@H](C[C@H]1C(N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C,VHL,,,aryl_O,16,6,0.4 uM,0.16 uM,Compound 2,FC1=CC(I)=CC=C1NC(N2C)=C(NS(C3=CC=CC=C3)(=O)=O)C=C(C)C2=O,O=CCOCOCOCCNC(=O)CO,PEG,15,7,10,1175.1099999999994,,,,VRA,31804822,Compound 5,No,,Reviewed,"P36507, Q02750",No,No,No,Yes,16,257.84999999999997
+739,O=C(N1CCC[C@H](N2C3=C(C(N)=NC=N3)C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)C1)/C(C#N)=C/C(C)(CCCOCCOCCOCCOCCOC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)C,Active,Yes,"Mino, Ramos",5.834280000000005,,Amit Shraga,6 nM,85 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,17,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,CC(C)CCCOCCOCCOCCOCCO,PEG,19,5,15,998.1069999999994,BLK,,,,32369353,RC-3,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",252.64999999999995
+740,O=C(N1CCC[C@H](N2C3=C(C(N)=NC=N3)C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)C1)CCCCCCOCCOCCOCCOCCOC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O,Active,Yes,"Mino, Ramos",5.528400000000005,,Amit Shraga,2.2 nM,97 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,16,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,CCCCCOCCOCCOCCOCCO,PEG,18,5,15,947.0589999999996,,,,,32369353,NC-1,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",228.85999999999999
+741,O=C(N1CCC[C@H](N2C3=C(C(N)=NC=N3)C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)C1)/C=C/CCCCOCCOCCOCCOCCOC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O,Active,No,"Mino, Ramos",5.304400000000005,,Amit Shraga,1.9 nM,88 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,16,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,CCCCOCCOCCOCCOCCO,PEG,17,5,14,945.0429999999996,,,,,32369353,IR-2,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",228.85999999999999
+742,O=C1N(C2CCC(NC2=O)=O)C(C3=CC=CC(OCCOCCOCCOCCOCCOC/C=C/C(N4CCC[C@H](C4)N5C6=C(C(C7=CC=C(C=C7)OC8=CC=CC=C8)=N5)C(N)=NC=N6)=O)=C31)=O,Active,No,"Mino, Ramos",4.150700000000004,,Amit Shraga,8.6 nM,91 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,17,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,COCCOCCOCCOCCOCCO,Other,17,6,14,947.0149999999999,,,,,32369353,IR-1,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",238.09000000000003
+743,O=C(/C(C#N)=C/CCCCOCCOCCOCCOCCOC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)N4CCC[C@@H](C4)N5C6=C(C(C7=CC=C(C=C7)OC8=CC=CC=C8)=N5)C(N)=NC=N6,Active,No,"Mino, Ramos",5.198180000000003,,Amit Shraga,35 nM,66 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,17,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,CCCCOCCOCCOCCOCCO,Other,17,5,14,970.0529999999995,,,,,32369353,RC-2,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",252.65000000000003
+744,O=C(CC1)NC(C1N2C(C(C=CC=C3OCCOCCOCCOCCOCCOC/C=C(C#N)/C(N(CCC4)C[C@@H]4N5N=C(C6=CC=C(C=C6)OC7=CC=CC=C7)C(C5=NC=N8)=C8N)=O)=C3C2=O)=O)=O,Inactive,No,"Mino, Ramos",4.044480000000004,,Amit Shraga,10 nM,68 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,18,2,,,Ibrutinib,C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N,COCCOCCOCCOCCOCCO,Other,17,6,14,972.0249999999997,,,,,32369353,RC-1,Yes,,Reviewed,Q06187,Yes,Yes,No,Yes,"1,2,4,6,24",261.88
+745,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,3.8256400000000026,IC50 of PROTAC with error of ± 13.8 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,132.2 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCC=O,Alkane,8,3,3,703.7560000000003,,,,,31813613,Compound 8,No,,Reviewed,O60885,No,No,No,No,,174.26
+746,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,4.215740000000004,IC50 of PROTAC with error of ± 15.4 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,138.4 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCCC=O,Alkane,9,3,4,717.7830000000004,,,,,31813613,Compound 9,No,,Reviewed,O60885,No,No,No,No,,174.26
+747,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,4.605840000000004,IC50 of PROTAC with error of ± 14.2 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,133.6 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCCCC=O,Alkane,10,3,5,731.8100000000004,,,,,31813613,Compound 10,No,,Reviewed,O60885,No,No,No,No,,174.26
+748,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,4.9959400000000045,IC50 of PROTAC with error of ± 8.7 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,99.1 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCCCCC=O,Alkane,11,3,6,745.8370000000004,,,,,31813613,Compound 11,No,,Reviewed,O60885,No,No,No,No,,174.26
+749,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,5.386040000000006,IC50 of PROTAC with error of ± 6.5 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,80.6 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCCCCCC=O,Alkane,12,3,7,759.8640000000004,,,,,31813613,Compound 12,No,,Reviewed,O60885,No,No,No,No,,174.26
+750,CC%11(C)CC/C(c1ccc(Cl)cc1)=C(CN%10CCN(c9ccc(C(=O)NS(=O)(=O)c8ccc(NC(CCN6CCN(C(=O)CCCn5cc(COCCOCCNc3cccc4c(=O)n(C2CCC(=O)NC2=O)c(=O)c34)nn5)CC6)CSc7ccccc7)c(S(=O)(=O)C(F)(F)F)c8)cc9)CC%10)\C%11,Active,Yes,WI38 platelets,8.763600000000006,,Barr Tivon,46 nM,96.2 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,21,4,,,ABT-263,C1(=CC=C(C=C1)C2=C(CC(CC2)(C)C)CN3CCN(CC3)C4=CC=C(C=C4)C(=O)N[S](C5=CC=C(C(=C5)[S](C(F)(F)F)(=O)=O)NC(CCN6CCNCC6)CSC7=CC=CC=C7)(=O)=O)Cl,CCOCCOCc1cn(CCCC=O)nn1,Other,17,6,10,1484.1569999999995,,,6QGH,1XJ,32332723,PZ15227,No,,Reviewed,Q07817,Yes,Yes,No,Yes,16,284.18999999999994
+751,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC(NCCCCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)C(N3C)=O)=C2,Active,No,,5.776140000000006,IC50 of PROTAC with error of ± 7.1 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,8,3,46.4 nM,68.3 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CC(=O)NCCCCCCCC=O,Alkane,13,3,8,773.8910000000003,,,3MXF,,31813613,Compound 13,No,,Reviewed,O60885,No,No,No,No,,174.26
+752,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)C(N3C)=O)=C2,Active,No,,5.489640000000006,IC50 of PROTAC with error of ± 13.6 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 nM,,other,7,2,46.4 nM,143.7 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CCCCC=O,Alkane,6,1,3,674.7580000000004,,,3MXF,,31813613,Compound 14,No,,Reviewed,O60885,No,No,No,No,,145.16
+753,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)C(N3C)=O)=C2,Active,No,,5.879740000000006,IC50 of PROTAC with error of ± 14.0 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,7,2,46.4 nM,135.1 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CCCCCC=O,Alkane,7,1,4,688.7850000000004,,,3MXF,,31813613,Compound 15,No,,Reviewed,O60885,No,No,No,No,,145.16
+754,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CCCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)C(N3C)=O)=C2,Active,No,,6.2698400000000065,IC50 of PROTAC with error of ± 12.6 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,7,2,46.4 nM,118.2 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,CCCCCCC=O,Alkane,8,1,5,702.8120000000005,,,3MXF,,31813613,Compound 16,No,,Reviewed,O60885,No,No,No,No,,145.16
+755,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(COCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,THP-1,4.0851400000000035,IC50 of PROTAC with error of ± 1.6 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 nM,1.83 uM,other,11,2,46.4 nM,14.2 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(COCC=O)nn1,PEG,11,5,4,743.7810000000003,,,3MXF,,31813613,Compound 17,No,,Reviewed,O60885,No,No,No,No,,185.09999999999997
+756,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,,4.1442400000000035,IC50 of PROTAC with error of ± 2.3 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,12,2,46.4 nM,15.4 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCCOCC=O)nn1,PEG,15,6,8,801.8610000000001,,,3MXF,,31813613,Compound 18,No,,Reviewed,O60885,No,No,No,No,,194.32999999999998
+757,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(COCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7=O)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,Yes,THP-1,3.7253400000000028,IC50 of PROTAC with error of ± 7.8 nM,"Shimrit Azulay, Daniel Zaidman",,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,0.81 uM,other,12,2,46.4 nM,41.8 nM,Compound 21,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(COCC=O)nn1,PEG,11,5,4,757.7640000000004,,,3MXF,,31813613,Compound 21,No,,Reviewed,O60885,No,Yes,No,No,,202.16999999999996
+758,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,,4.1183400000000026,IC50 of PROTAC with error of ± 2.9 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,13,2,46.4 nM,22.1 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCOCCOCC=O)nn1,PEG,17,7,10,831.8870000000001,,,3MXF,,31813613,Compound 19,No,,Reviewed,O60885,No,No,No,No,,203.56
+759,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCOCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,,4.0924400000000025,IC50 of PROTAC with error of ± 3.7 nM,Shimrit Azulay,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,14,2,46.4 nM,22.6 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCOCOCCOCC=O)nn1,PEG,19,8,12,861.913,,,3MXF,,31813613,Compound 20,No,,Reviewed,O60885,No,No,No,No,,212.78999999999996
+760,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7=O)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,THP-1,3.7844400000000027,IC50 of PROTAC with error of ± 9.0 nM,Shimrit Azulay,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,1.66 uM,other,13,2,46.4 nM,67.7 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCCOCC=O)nn1,PEG,15,6,8,815.8440000000002,,,3MXF,,31813613,Compound 22,No,,Reviewed,O60885,No,No,No,No,,211.39999999999998
+761,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7=O)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,THP-1,3.7585400000000027,IC50 of PROTAC with error of ± 8.5 nM,Shimrit Azulay,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,1.75 uM,other,14,2,46.4 nM,68.5 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCOCCOCC=O)nn1,PEG,17,7,10,845.8700000000001,,,3MXF,,31813613,Compound 23,No,,Reviewed,O60885,No,No,No,No,,220.63
+762,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)N(CC5=CN(CCOCOCOCCOCC(NC6=C7C(C(N(C8CCC(NC8=O)=O)C7=O)=O)=CC=C6)=O)N=N5)C(N3C)=O)=C2,Active,No,,3.7326400000000017,IC50 of PROTAC with error of ± 23.2 nM,Shimrit Azulay,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,3.26 uM,,other,15,2,46.4 nM,173.4 nM,compound 6,CC1=NOC(C)=C1C2=CC=C3C(C(C4=CC=CC=C4)NC(N3C)=O)=C2,Cc1cn(CCOCOCOCCOCC=O)nn1,PEG,19,8,12,875.8960000000001,,,3MXF,,31813613,Compound 24,No,,Reviewed,O60885,No,No,No,No,,229.85999999999996
+763,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=CC7=C(C=CC=C7)C=N6)=CC=N5)=O)NC1=O,Inactive,No,"MCF7, A549",4.420700000000002,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,4,,,"2,4-bis-arylamino-1,3-pyrimidine",OC(C=C1)=CC=C1NC2=NC(NC3=CC4=C(C=CC=C4)C=N3)=CC=N2,CCOCC,PEG,5,1,2,672.7020000000002,,,3QQU,,32340152,10a,No,,Reviewed,"P08069, P12931",No,No,No,No,72,176.77
+764,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=CC7=C(C=CC=C7)C=N6)=CC=N5)=O)NC1=O,Inactive,No,"MCF7, A549",4.437300000000001,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,4,,,"2,4-bis-arylamino-1,3-pyrimidine",OC(C=C1)=CC=C1NC2=NC(NC3=CC4=C(C=CC=C4)C=N3)=CC=N2,CCOCCOCC,PEG,8,2,5,716.7550000000002,,,3QQU,,32340152,10b,No,,Reviewed,"P08069, P12931",No,No,No,No,72,186.0
+765,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=CC7=C(C=CC=C7)C=N6)=CC=N5)=O)NC1=O,Inactive,No,"MCF7, A549",4.453900000000002,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,4,,,"2,4-bis-arylamino-1,3-pyrimidine",OC(C=C1)=CC=C1NC2=NC(NC3=CC4=C(C=CC=C4)C=N3)=CC=N2,CCOCCOCCOCC,PEG,11,3,8,760.8080000000002,,,3QQU,,32340152,10c,No,,Reviewed,"P08069, P12931",No,No,No,No,72,195.23
+766,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=NNC(C)=C6)=CC=N5)=O)NC1=O,Active,Yes,"MCF7, A549",2.904020000000001,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,5,,< 4.2 uM,"N2-phenyl-N4-(1H-pyrazol-3-yl)pyrimidine-2,4-diamine",OC(C=C1)=CC=C1NC2=NC(NC3=NNC(C)=C3)=CC=N2,CCOCC,PEG,5,1,2,625.6460000000002,,,,,32340152,12a,No,,Reviewed,"P08069, P12931",No,No,No,No,24,192.55999999999997
+767,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=NNC(C)=C6)=CC=N5)=O)NC1=O,Active,Yes,"MCF7, A549",2.9206199999999995,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,5,,< 7.6 uM,"N2-phenyl-N4-(1H-pyrazol-3-yl)pyrimidine-2,4-diamine",OC(C=C1)=CC=C1NC2=NC(NC3=NNC(C)=C3)=CC=N2,CCOCCOCC,PEG,8,2,5,669.6990000000002,,,,,32340152,"12b, CPR4",No,,Reviewed,"P08069, P12931",No,No,No,No,24,201.79
+768,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=NNC(C)=C6)=C(Cl)C=N5)=O)NC1=O,Inactive,No,"MCF7, A549",3.574019999999999,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,5,,,"N2-phenyl-N4-(1H-pyrazol-3-yl)pyrimidine-2,4-diamine",OC(C=C1)=CC=C1NC2=NC(NC3=NNC(C)=C3)=CC=N2,CCOCCOCC,PEG,8,2,5,704.1440000000001,,,,,32340152,12d,No,,Reviewed,"P08069, P12931",No,No,No,No,72,201.79
+769,O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3NCCOCCOC(C=C4)=CC=C4NC5=NC(NC6=NNC(C)=C6)=C(Cl)C=N5)=O)NC1=O,Inactive,No,"MCF7, A549",3.5574200000000005,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,12,5,,,"N2-phenyl-N4-(1H-pyrazol-3-yl)pyrimidine-2,4-diamine",OC(C=C1)=CC=C1NC2=NC(NC3=NNC(C)=C3)=CC=N2,CCOCC,PEG,5,1,2,660.0910000000001,,,,,32340152,12c,No,,Reviewed,"P08069, P12931",No,No,No,No,72,192.55999999999997
+770,NC1=C2C(N(CC3=CN(CC(NC4=CC=C(OCCOCCNC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)C=C4)=O)N=N3)N=C2C8=CC=C(Cl)C=C8)=NC=N1,Inactive,No,"MCF7, A549",2.916100000000002,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCOCCOc1ccc(NC(=O)Cn2cc(C)nn2)cc1,Other,22,7,8,819.239,,,,,32340152,16a,No,,Reviewed,"P08069, P12931",No,No,No,No,72,243.4699999999999
+771,O=C([C@H]1N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)CC(C=C(OCCOCCOCCOCCOC(C(S(C(C)(C)C)(=O)=O)=C2)=CC3=C2C(NC(C=C4)=CC5=C4SC=N5)=CC=N3)C=C6)=C6C1)N[C@H]7CCCC8=CC=CC=C87,Active,No,THPT1,8.253800000000007,,"Amit Shraga, Daniel Zaidman",< 1 uM,> 80 %,O=C([C@H]1N(C([C@@H](NC([C@@H](NC)C)=O)C(C)(C)C)=O)CC(C=CC=C2)=C2C1)N[C@H]3CCCC4=CC=CC=C43,Iap,,,aryl_O,15,4,,,RIP-2 kinase,O=S(C1=CC2=C(C=C1)N=CC=C2NC(C=C3)=CC4=C3SC=N4)(C(C)(C)C)=O,OCCOCCOCCOCCO,PEG,13,5,10,1092.395,,US10336744B2,,,,7a,No,,Reviewed,O43353,No,No,No,No,,208.64000000000001
+772,CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C(C=C3)=CC=C3OCCN(C)CCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)=O,Active,No,MCF-7,7.36272000000001,,"Amit Shraga, Daniel Zaidman",< 1 uM,,N[C@H](C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O)=O)C(C)(C)C.Cl,VHL,,,other,12,4,,,tamoxifen,CC[N]CCOc1ccc(/C(c2ccc(O)cc2)=C(c3ccccc3)/CC)cc1,O=CCOCCOCCO,PEG,10,4,7,976.2499999999999,,ES2717436T3,2JF9,,,"(25.4R) -1 - ((S) -2- (tert -Butyl) -17- (4 - ((Z) -1,2-diphenylbut-1-en-1-yl) phenoxy) -15- methyl-4-oxo-6,9,12-trioxa-3,15-diazaheptadecan-I-oil) -4-hydroxy-M- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide N26699-42",No,,Reviewed,P03372,No,No,No,No,24,172.01999999999998
+773,CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C(C=C3)=CC=C3OCCN(C)CCOCCOCCOCC(N[C@@H](C(C)C)C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)=O,Active,No,MCF-7,6.97262000000001,,"Amit Shraga, Daniel Zaidman",< 1 uM,,N[C@H](C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O)=O)C(C)(C)C.Cl,VHL,,,other,12,4,,,tamoxifen,CC[N]CCOc1ccc(/C(c2ccc(O)cc2)=C(c3ccccc3)/CC)cc1,O=CCOCCOCCO,Other,10,4,7,962.223,,ES2717436T3,2JF9,,,"(2S, 4R) -1 - ((S) -17- (4 - ((Z) 2-Diphenylbut-1-en-I-yl) phenoxy) -2-isopropyl-15-methyl-4-oxo-6 , 9,12-trioxa-3,15-diazaheptadecan-I-oil) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide N26699-42",No,,Reviewed,P03372,No,No,No,No,24,172.01999999999998
+774,NC1=C2C(N(CC3=CN(CC(NC4=CC=C(OCCOCCOCCNC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)C=C4)=O)N=N3)N=C2C8=CC=C(Cl)C=C8)=NC=N1,Inactive,No,"MCF7, A549",2.9327000000000023,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCOCCOCCOc1ccc(NC(=O)Cn2cc(C)nn2)cc1,Other,25,8,11,863.292,,,,,32340152,16b,No,,Reviewed,"P08069, P12931",No,No,No,No,72,252.69999999999993
+775,NC1=C2C(N(CCCNC3=CC=C(OCCOCCOCCNC4=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=CC=C4)C=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1,Inactive,No,"MCF7, A549",4.156400000000003,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCCNc1ccc(OCCOCCOCC)cc1,Other,19,4,11,782.2580000000002,,,,,32340152,18b,No,,Reviewed,"P08069, P12931",No,No,No,No,72,204.91999999999996
+776,NC1=C2C(N(CCCNC3=CC=C(OCCOCCNC4=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=CC=C4)C=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1,Inactive,No,"MCF7, A549",4.139800000000004,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCCNc1ccc(OCCOCC)cc1,Other,16,3,8,738.2050000000002,,,,,32340152,18a,No,,Reviewed,"P08069, P12931",No,No,No,No,72,195.68999999999994
+777,NC1=C2C(N(CCCN3N=NC(CNC4=CC=C(OCCOCCOCCNC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)C=C4)=C3)N=C2C8=CC=C(Cl)C=C8)=NC=N1,Inactive,No,"MCF7, A549",3.948100000000003,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCCn1cc(CNc2ccc(OCCOCCOCC)cc2)nn1,Other,25,7,13,863.3360000000004,,,,,32340152,21b,No,,Reviewed,"P08069, P12931",No,No,No,No,72,235.62999999999994
+778,NC1=C2C(N(CCCN3N=NC(CNC4=CC=C(OCCOCCNC5=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=CC=C5)C=C4)=C3)N=C2C8=CC=C(Cl)C=C8)=NC=N1,Inactive,No,"MCF7, A549",3.9315000000000033,,Barr Tivon,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,,,"aminopyrazolo [3,4-d]pyrimidine",NC1=C2C(NN=C2C3=CC=CC=C3)=NC=N1,CCCn1cc(CNc2ccc(OCCOCC)cc2)nn1,Other,22,6,10,819.2830000000002,,,,,32340152,21a,No,,Reviewed,"P08069, P12931",No,No,No,No,72,226.39999999999998
+779,O=C(C1=C2C(OCCOCCOCCOCCOCCOC/C=C\C(N3C[C@H](N(CC3)C4=NC(N(C5=C4C=C(C(C6=C(C=CC=C6F)O)=N5)F)C7=C(C=CN=C7C(C)C)C)=O)C)=O)=CC=C1)N(C(C(N8)=O)CCC8=O)C2=O,Inactive,No,HOP62/INC-H23,4.414820000000002,Inactive PROTAC for KRAS based on AMG-510.,Ronen Gabizon,,,O=C(N(C1=O)C(CC2)C(NC2=O)=O)C3=C1C=CC=C3,Cereblon,68 nM,,aliphatic_CC,18,2,~ 50 nM,,AMG-510,C=CC(N1C[C@H](N(CC1)C2=NC(N(C3=C2C=C(C(C4=C(C=CC=C4F)O)=N3)F)C5=C(C=CN=C5C(C)C)C)=O)C)=O,COCCOCCOCCOCCOCCO,PEG,17,6,14,1067.1129999999998,,,6OIM,MOV,,RG40,No,,Reviewed,P01116,No,No,No,No,24,243.37999999999997
+780,NC(C1=CC(C(N(C2=O)CC(NCCNc3c(C4=O)c(C(N4C(CC5)C(NC5=O)=O)=O)ccc3)=O)=O)=C(N=C1N)N2C6CC6)=O,Inactive,No,MDA-MB-231,-1.7962999999999956,"There was no reported structure for full-length eEF2K. The structure of target-ligand complex was generated using homology modelling (PDB code 5E4H); IC50 of this ligand (A484954) was reported as 0.42uM in another paper (10.1016/j.bmc.2014.06.050), which can be accounted for by the difference in ATP concentration in assays.","Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCN,Alkane,4,2,1,617.579,No,,,,32717479,9a,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+781,NC(C1=CC(C(N(CC(NCCCNc2cccc(C(N3C(C(N4)=O)CCC4=O)=O)c2C3=O)=O)C5=O)=O)=C(N5C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-1.4061999999999961,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCN,Alkane,5,2,2,631.606,No,,,,32717479,9b,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+782,NC(C1=CC(C(N(CC(NCCCCNc2cccc(C(N3C(C(N4)=O)CCC4=O)=O)c2C3=O)=O)C5=O)=O)=C(N5C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-1.0160999999999965,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCN,Alkane,6,2,3,645.633,No,,,,32717479,9c,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+783,NC(C1=CC(C(N(CC(NCCCCCNc2cccc(C(N3C(C(N4)=O)CCC4=O)=O)c2C3=O)=O)C5=O)=O)=C(N5C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-0.6259999999999968,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCCN,Alkane,7,2,4,659.66,No,,,,32717479,9d,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+784,NC(C1=CC(C(N2CC(NCCCCCCNc3c(C4=O)c(C(N4C(CC5)C(NC5=O)=O)=O)ccc3)=O)=O)=C(N=C1N)N(C6CC6)C2=O)=O,Inactive,No,MDA-MB-231,-0.235899999999996,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCCCN,Alkane,8,2,5,673.6869999999999,No,,,,32717479,9e,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+785,NC(C1=CC(C(N2CC(NCCOCCNc3c(C4=O)c(C(N4C(CC5)C(NC5=O)=O)=O)ccc3)=O)=O)=C(N=C1N)N(C6CC6)C2=O)=O,Inactive,No,MDA-MB-231,-1.7796999999999952,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCOCCN,Other,7,3,4,661.632,No,,,,32717479,9f,No,25047940,Reviewed,O00418,No,No,No,No,24,259.91
+786,NC(C1=CC(C(N2CC(NCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-2.7131999999999943,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCNC(=O)CO,Alkane,8,4,3,675.6149999999999,No,,,,32717479,11a,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+787,NC(C1=CC(C(N2CC(NCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-2.323099999999994,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCNC(=O)CO,Alkane,9,4,4,689.6419999999999,No,,,,32717479,11b,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+788,NC(C1=CC(C(N2CC(NCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-1.9329999999999936,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCNC(=O)CO,Alkane,10,4,5,703.669,No,,,,32717479,11c,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+789,NC(C1=CC(C(N2CC(NCCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-1.5428999999999944,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCCNC(=O)CO,Alkane,11,4,6,717.696,No,,,,32717479,11d,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+790,NC(C1=CC(C(N2CC(NCCCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-1.1527999999999947,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCCCCCNC(=O)CO,Alkane,12,4,7,731.7230000000001,No,,,,32717479,11e,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+791,NC(C1=CC(C(N2CC(NCCOCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)C6CC6)N=C1N)=O,Inactive,No,MDA-MB-231,-2.696599999999993,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,5,0.28 uM,,A484954,O=C(N(CC)C1=O)N(C2CC2)C3=C1C=C(C(N)=O)C(N)=N3,NCCOCCNC(=O)CO,Other,11,5,6,719.668,No,,,,32717479,11f,No,25047940,Reviewed,O00418,No,No,No,No,24,286.2099999999999
+792,NC(C1=CC(C(N2CC(NCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-3.028199999999994,,"Yangwode Jing, Daniel Zaidman",,10.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCNC(=O)CO,Alkane,8,4,3,663.6039999999999,No,,,,32717479,11g,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+793,NC(C1=CC(C(N2CC(NCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-2.6380999999999935,,"Yangwode Jing, Daniel Zaidman",,15.4 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCNC(=O)CO,Alkane,9,4,4,677.631,No,,,,32717479,11h,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+794,NC(C1=CC(C(N2CC(NCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-2.247999999999993,,"Yangwode Jing, Daniel Zaidman",,26.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCNC(=O)CO,Alkane,10,4,5,691.658,No,,,,32717479,11i,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+795,NC(C1=CC(C(N2CC(NCCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-1.8578999999999937,,"Yangwode Jing, Daniel Zaidman",,32.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCCNC(=O)CO,Alkane,11,4,6,705.6850000000001,No,,,,32717479,11j,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+796,NC(C1=CC(C(N2CC(NCCCCCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-1.4677999999999936,,"Yangwode Jing, Daniel Zaidman",,35.3 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCCCNC(=O)CO,Alkane,12,4,7,719.7120000000001,No,,,,32717479,11k,No,25047940,Reviewed,O00418,No,No,No,No,24,276.9799999999999
+797,NC(C1=CC(C(N2CC(NCCOCCNC(COc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,Yes,MDA-MB-231,-3.0115999999999925,,"Yangwode Jing, Daniel Zaidman",,56.7 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,15,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCOCCNC(=O)CO,Other,11,5,6,707.657,No,,,,32717479,11l,No,25047940,Reviewed,O00418,No,No,No,Yes,24,286.2099999999999
+798,NC(C1=CC(C(N2CC(NCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Inactive,No,MDA-MB-231,-2.1112999999999955,,"Yangwode Jing, Daniel Zaidman",,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCN,Alkane,4,2,1,605.5680000000001,No,,,,32717479,9g,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+799,NC(C1=CC(C(N2CC(NCCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-1.7211999999999952,,"Yangwode Jing, Daniel Zaidman",,20.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCN,Alkane,5,2,2,619.595,No,,,,32717479,9h,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+800,NC(C1=CC(C(N2CC(NCCCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-1.3310999999999953,,"Yangwode Jing, Daniel Zaidman",,35.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCN,Alkane,6,2,3,633.6220000000001,No,,,,32717479,9i,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+801,NC(C1=CC(C(N2CC(NCCCCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-0.940999999999995,,"Yangwode Jing, Daniel Zaidman",,24.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCCN,Alkane,7,2,4,647.649,No,,,,32717479,9j,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+802,NC(C1=CC(C(N2CC(NCCCCCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-0.5508999999999953,,"Yangwode Jing, Daniel Zaidman",,20.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,13,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCCCCCN,Alkane,8,2,5,661.6759999999999,No,,,,32717479,9k,No,25047940,Reviewed,O00418,No,No,No,No,24,250.67999999999998
+803,NC(C1=CC(C(N2CC(NCCOCCNc3c(C(N(C4=O)C5C(NC(CC5)=O)=O)=O)c4ccc3)=O)=O)=C(N(C2=O)CC)N=C1N)=O,Active,No,MDA-MB-231,-2.0946999999999942,,"Yangwode Jing, Daniel Zaidman",,15.0 %,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,other,14,5,~ 1 uM,,Ethyl-substituted A484954,CCN(C(N1CC)=O)C(C2=C1N=C(C(C(N)=O)=C2)N)=O,NCCOCCN,Other,7,3,4,649.621,No,,,,32717479,9l,No,25047940,Reviewed,O00418,No,No,No,No,24,259.90999999999997
+804,O=C(NC1=O)CCC1N(C2=O)CC3=C2C=CC=C3NC(COCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(F)C=C5)=N/O)=O,Inactive,No,HeLa,1.6535000000000026,EC50 for ligand Epa was also reported as 7.1nM; Cytotoxicity IC50 (CC50) for PROTAC 1a: >40uM,Yangwode Jing,,,NC1=CC=CC2=C1CN(C2=O)C3CCC(NC3=O)=O,Cereblon,12 nM,,other,13,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCC=O,PEG,9,3,6,746.5510000000004,No,,5WN8,BBJ,33163345,1a,No,,Reviewed,P14902,No,No,No,No,24,221.63999999999996
+805,O=C(NC1=O)CCC1N(C2=O)CC3=C2C=CC=C3NC(COCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(F)C=C5)=N/O)=O,Inactive,No,HeLa,1.6701000000000037,Cytotoxicity IC50 (CC50): >40uM,Yangwode Jing,,,NC1=CC=CC2=C1CN(C2=O)C3CCC(NC3=O)=O,Cereblon,12 nM,,other,14,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCC=O,PEG,12,4,9,790.6040000000003,No,,5WN8,BBJ,33163345,1b,No,,Reviewed,P14902,No,No,No,No,24,230.86999999999998
+806,O=C(NC1=O)CCC1N(C2=O)CC3=C2C=CC=C3NC(COCCOCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(F)C=C5)=N/O)=O,Inactive,No,HeLa,1.6867000000000036,Cytotoxicity IC50 (CC50): >40uM,Yangwode Jing,,,NC1=CC=CC2=C1CN(C2=O)C3CCC(NC3=O)=O,Cereblon,12 nM,,other,15,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCCOCC=O,PEG,15,5,12,834.6570000000004,No,,5WN8,BBJ,33163345,1c,No,,Reviewed,P14902,No,No,No,No,24,240.09999999999994
+807,O=C(CCC1N(C(C2=C3C=CC=C2NC(COCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(C=C5)F)=N/O)=O)=O)C3=O)NC1=O,Inactive,No,HeLa,1.310300000000002,Cytotoxicity IC50 (CC50): 34.27uM,Yangwode Jing,,,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,Cereblon,12 nM,,other,15,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCC=O,PEG,12,4,9,804.5870000000004,No,,5WN8,BBJ,33163345,2a,No,,Reviewed,P14902,No,No,No,No,24,247.94
+808,O=C(CCC1N(C(C2=C3C=CC=C2NC(COCCOCCOCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(C=C5)F)=N/O)=O)=O)C3=O)NC1=O,Inactive,No,HeLa,1.3435000000000064,Cytotoxicity IC50 (CC50): 35.38uM,Yangwode Jing,,,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,Cereblon,12 nM,,other,17,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCCOCCOCC=O,PEG,18,6,15,892.6930000000003,No,,5WN8,BBJ,33163345,2b,No,,Reviewed,P14902,No,No,No,No,24,266.4
+809,O=C(CCC1N(C(C2=C3C=CC=C2NC(COCCOCCOCCOCCOCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(C=C5)F)=N/O)=O)=O)C3=O)NC1=O,Active,Yes,HeLa,1.376700000000008,Cytotoxicity IC50 (CC50): 37.43uM,Yangwode Jing,2.84 uM,93 %,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,Cereblon,12 nM,,other,19,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCCOCCOCCOCCOCC=O,PEG,24,8,21,980.7990000000002,No,,5WN8,BBJ,33163345,2c,No,,Reviewed,P14902,Yes,Yes,No,Yes,24,284.85999999999996
+810,O=C(CCC1N(C(C2=C3C=CC=C2NC(COCCOCCOCCOCCOCCOCCOCCOCCOCCNCCNC4=NON=C4/C(NC5=CC(Br)=C(C=C5)F)=N/O)=O)=O)C3=O)NC1=O,Inactive,No,HeLa,1.4099000000000113,Cytotoxicity IC50 (CC50): >40uM,Yangwode Jing,,,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,Cereblon,12 nM,,other,21,6,72 nM,,Epacadostat,O=S(NCCNC1=NON=C1/C(NC2=CC(Br)=C(F)C=C2)=N/O)(N)=O,CCOCCOCCOCCOCCOCCOCCOCCOCCOCC=O,PEG,30,10,27,1068.905,No,,5WN8,BBJ,33163345,2d,No,,Reviewed,P14902,No,No,No,No,24,303.31999999999994
+811,O=C1C2=C(C(N1C3CCC(NC3=O)=O)=O)C=CC=C2OCC(NCCCCCC(NC4=CC=C(C(NC(C=CC=C5)=C5N)=O)C=C4)=O)=O,Inactive,No,E14 mouse embryonic stem cells; Human colon cancer cell line HCT116,2.6163999999999987,,Yangwode Jing,,,O=C(CC1)NC(C1N2C(C(C=CC=C3)=C3C2=O)=O)=O,Cereblon,,,aliphatic_CC,9,5,0.53 uM,0.92 uM,CI-994,O=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2,CCCCNC(=O)CO,Alkane,9,3,4,654.6800000000004,No,,4LY1,20Y,32201871,1,No,,Reviewed,"O15379, Q13547, Q92769",No,No,No,No,24,206.1
+812,O=C1C2=C(C(N1C3CCC(NC3=O)=O)=O)C=CC=C2OCC(NCCCCCCCCCCCC(NC4=CC=C(C(NC(C=CC=C5)=C5N)=O)C=C4)=O)=O,Active,No,E14 mouse embryonic stem cells; Human colon cancer cell line HCT116,4.957000000000002,,Yangwode Jing,~ 10 uM,,O=C(CC1)NC(C1N2C(C(C=CC=C3)=C3C2=O)=O)=O,Cereblon,,,aliphatic_CC,9,5,0.53 uM,8.6 uM,CI-994,O=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2,CCCCCCCCCCNC(=O)CO,Alkane,15,3,10,738.8420000000006,No,,4LY1,20Y,32201871,2,No,,Reviewed,"O15379, Q13547, Q92769",No,No,No,No,24,206.1
+813,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCC(NC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)=O)=O)=O,Inactive,No,E14 mouse embryonic stem cells; Human colon cancer cell line HCT116,5.261020000000003,,Yangwode Jing,,,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)N)=O,VHL,,,aliphatic_CC,9,6,0.53 uM,0.70 uM,CI-994,O=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2,CCCC=O,Alkane,5,1,2,767.9530000000003,No,,4LY1,20Y,32201871,3,No,,Reviewed,"O15379, Q13547, Q92769",No,No,No,No,24,195.85
+814,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCCCCCC(NC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)=O)=O)=O,Active,Yes,E14 mouse embryonic stem cells; Human colon cancer cell line HCT116,7.601620000000008,"For HDAC1/HDAC2/HDAC3, the Dmax of this PROTAC is: >85%, >76%, >63%, respectively.",Yangwode Jing,~ 1 uM,,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)N)=O,VHL,,,aliphatic_CC,9,6,0.53 uM,16.8 uM,CI-994,O=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2,CCCCCCCCCC=O,Alkane,11,1,8,852.115,No,,4LY1,20Y,32201871,4,No,,Reviewed,"O15379, Q13547, Q92769",Yes,No,No,No,24,195.85
+815,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCCCCC4CCN(CCNC(C5=CC6=C(O5)C(C7=CC=CC=C7C6=O)=O)=O)CC4,Active,Yes,Pancreatic cancer cell lines BxPC-3; MIA PaCa-2,3.570500000000002,"XD2-149 was initially designed to degrade STAT3. However, experiments showed that XD2-149 down-regulate STAT3 level in a proteasome-independent manner. Proteomics data revealed that an E3 ligase, ZFP91, was the true substrate for this PROTAC. This paper reported a total of 22 PROTACs, which differed from each other in linker design and E3 binder choices (pomalidomide/thalidomide/lenalidomide). However, the authors didn't mention whether the remaining 21 molecules could degrade ZFP91 or not. It is also interesting that pomalidomide itself can induce the degradation of CRBN neo-substrates like ZFP91 (DC50: 0.42uM, 5-fold less potent than XD2-149), since pomalidomide can remodel CRBN surface for binding proteins like ZFP91 (Nat Med., 2019, doi: 10.1038/s41591-019-0668-z).",Yangwode Jing,~ 70 nM,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,~ 1 uM,other,10,3,,,Napabucasin,O=C(C1=C2C=C(C(C)=O)O1)C3=CC=CC=C3C2=O,CCCCCC1CCN(CCN)CC1,Other,14,2,6,693.7570000000003,No,,,,33506674,XD2-149,Yes,,Reviewed,Q96JP5,Yes,Yes,No,Yes,"16, 24",175.2
+816,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,4.817920000000003,,Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CNC=O,Alkane,4,2,1,948.6169999999996,No,,5EHR,5OD,32437146,SHP2-D7,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+817,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,5.208020000000002,,Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCNC=O,Alkane,5,2,2,962.6439999999996,No,,5EHR,5OD,32437146,SHP2-D8,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+818,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,5.598120000000003,,Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCNC=O,Alkane,6,2,3,976.6709999999995,No,,5EHR,5OD,32437146,SHP2-D9,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+819,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,5.988220000000004,,Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCNC=O,Alkane,7,2,4,990.6979999999995,No,,5EHR,5OD,32437146,SHP2-D10,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+820,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,6.378320000000005,,Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCNC=O,Alkane,8,2,5,1004.7249999999995,No,,5EHR,5OD,32437146,SHP2-D11,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+821,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Inactive,No,KYSE520 esophageal cancer cell line,6.768420000000005,Degradation rate: 20% (0.1uM compound) or 14% (1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCNC=O,Alkane,9,2,6,1018.7519999999994,No,,5EHR,5OD,32437146,SHP2-D12,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+822,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,7.158520000000006,,Yangwode Jing,,80 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCNC=O,Alkane,10,2,7,1032.7789999999993,No,,5EHR,5OD,32437146,SHP2-D13,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+823,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,7.548620000000006,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCNC=O,Alkane,11,2,8,1046.8059999999991,No,,5EHR,5OD,32437146,SHP2-D14,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+824,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,7.938720000000007,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCNC=O,Alkane,12,2,9,1060.8329999999992,No,,5EHR,5OD,32437146,SHP2-D15,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+825,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCCCNC(CC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,8.328820000000007,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCCNC=O,Alkane,13,2,10,1074.859999999999,No,,5EHR,5OD,32437146,SHP2-D16,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+826,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCCNC(CCC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,8.328820000000007,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCNC(C)=O,Alkane,13,2,8,1074.859999999999,No,,5EHR,5OD,32437146,SHP2-D17,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+827,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCCCNC(CCC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,8.718920000000006,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCCNC(C)=O,Alkane,14,2,9,1088.886999999999,No,,5EHR,5OD,32437146,SHP2-D18,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+828,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(CCCCCCCCCCCNC(CCCC(NC4=CC=CC(SC5=NC=C(N=C5N)N6CCC(C)(CC6)N)=C4Cl)=O)=O)=O)=O,Active,No,KYSE520 esophageal cancer cell line,9.109020000000005,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,14,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCCNC(=O)CC,Alkane,15,2,10,1102.913999999999,No,,5EHR,5OD,32437146,SHP2-D19,No,,Reviewed,Q06124,No,No,No,No,6,250.89000000000001
+829,O=C([C@H]1N(C([C@H](NC(COCCOCCOCCNC(CCC(CCC(NC2=CC=CC(SC3=NC=C(N4CCC(CC4)(N)C)N=C3N)=C2Cl)=O)=O)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,5.217020000000012,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,18,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CC(=O)CCC(=O)NCCOCCOCCO,PEG,17,6,11,1136.8399999999992,No,,5EHR,5OD,32437146,SHP2-D20,No,,Reviewed,Q06124,No,No,No,No,6,295.6499999999999
+830,O=C([C@H]1N(C([C@H](NC(CCOCCOCCOCCNC(CCC(CCC(NC2=CC=CC(SC3=NC=C(N4CCC(CC4)(N)C)N=C3N)=C2Cl)=O)=O)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,5.607120000000012,Degradation rate for KYSE520 cell: 87% (1uM compound); Degradation rate for MV4;11 cell: 85% (0.1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,18,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,COCCOCCOCCNC(=O)CCC(C)=O,PEG,18,6,12,1150.8669999999993,No,,5EHR,5OD,32437146,SHP2-D21,No,,Reviewed,Q06124,No,No,No,No,6,295.6499999999999
+831,O=C([C@H]1N(C([C@H](NC(CCOCCOCCOCCOCCNC(CCC(CCC(NC2=CC=CC(SC3=NC=C(N4CCC(CC4)(N)C)N=C3N)=C2Cl)=O)=O)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,5.623720000000012,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,19,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,COCCOCCOCCOCCNC(=O)CCC(C)=O,PEG,21,7,15,1194.9199999999992,No,,5EHR,5OD,32437146,SHP2-D22,No,,Reviewed,Q06124,No,No,No,No,6,304.88
+832,O=C([C@H]1N(C([C@H](NC(CCCCCCCCCCN2CCN(CC2)CC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,8.050020000000009,Dmax for KYSE520 cell: >95%; Degradation rate in MV4;11 cell: 47% (0.1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,other,15,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCN1CCNCC1,Other,15,2,8,1101.9299999999992,No,,5EHR,5OD,32437146,SHP2-D23,No,,Reviewed,Q06124,No,No,No,No,6,228.26999999999998
+833,O=C([C@H]1N(C([C@H](NC(CCCCCCCCCCCN2CCN(CC2)CC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,8.440120000000006,Dmax for KYSE520 cell: >95%; Degradation rate in MV4;11 cell: 6% (0.1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,other,15,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCCN1CCNCC1,Other,16,2,9,1115.9569999999992,No,,5EHR,5OD,32437146,SHP2-D24,No,,Reviewed,Q06124,No,No,No,No,6,228.26999999999998
+834,O=C([C@H]1N(C([C@H](NC(CCCCCCCCCCCCCCC(NC2=CC=CC(SC3=NC=C(N4CCC(CC4)(N)C)N=C3N)=C2Cl)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,10.382919999999995,Degradation rate in KYSE520 cell: 90% (1uM compound); Degradation rate in MV4;11 cell: 8% (0.1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,13,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCCCCC,Alkane,12,0,9,1059.8889999999992,No,,5EHR,5OD,32437146,SHP2-D25,No,,Reviewed,Q06124,No,No,No,No,6,221.78999999999996
+835,O=C([C@H]1N(C([C@H](NC(CCCCCCCCN2CCN(C(CCC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,Yes,KYSE520 esophageal cancer cell line; MV4;11 cell line,7.576620000000008,DC50 for KYSE520 cell: 6.0nM;DC50 for MV4;11 cell: 2.6nM; EC50 for KYSE520 cell: 0.66uM; EC50 for MV4;11 cell: 9.9nM;,Yangwode Jing,6.0 nM,100 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,0.66 uM,aliphatic_CC,15,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCN1CCN(C(C)=O)CC1,Other,16,3,6,1115.912999999999,No,,5EHR,5OD,32437146,SHP2-D26,No,,Reviewed,Q06124,No,Yes,No,Yes,"6, 12",245.33999999999997
+836,O=C([C@H]1N(C([C@H](NC(CCCCCCCCCN2CCN(C(CCC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,7.9667200000000085,,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,15,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCCCN1CCN(C(C)=O)CC1,Other,17,3,7,1129.939999999999,No,,5EHR,5OD,32437146,SHP2-D27,No,,Reviewed,Q06124,No,No,No,No,6,245.33999999999997
+837,O=C([C@H]1N(C([C@H](NC(CCCCCCCN2CCN(C(CCC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,7.186520000000008,Dmax for KYSE520 cell: >95%; Dmax for MV4;11 cell: >90%,Yangwode Jing,,> 95 %,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,15,6,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCCCCN1CCN(C(C)=O)CC1,Other,15,3,5,1101.885999999999,No,,5EHR,5OD,32437146,SHP2-D28,No,,Reviewed,Q06124,No,No,No,No,6,245.33999999999997
+838,O=C([C@H]1N(C([C@H](NC(CCCCN2CCN(CCCCNC(CCC(NC3=CC=CC(SC4=NC=C(N5CCC(CC5)(N)C)N=C4N)=C3Cl)=O)=O)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C,Active,No,KYSE520 esophageal cancer cell line; MV4;11 cell line,6.386020000000012,Dmax for KYSE520 cell: >80%; Degradation rate for MV4;11 cell: 9% (0.1uM compound),Yangwode Jing,,,O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](C(C)(C)C)NC(C)=O)=O,VHL,,,aliphatic_CC,16,7,98.7 nM,,SHP2 inhibitor 5,ClC1=C(C=CC=C1NC(C)=O)SC2=NC=C(N=C2N)N3CCC(C)(CC3)N,CCCN1CCN(CCCCNC(C)=O)CC1,Other,17,4,7,1130.927999999999,No,,5EHR,5OD,32437146,SHP2-D29,No,,Reviewed,Q06124,No,No,No,No,6,257.36999999999995
+839,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)C=C1,Active,No,"HeLa, HL60, MV4;11",5.580080000000005,"pEC50 for MV4;11 and HL60 cells: 6.75±0.03 and 5.84±0.06, respectively.
+pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 7.0/7.0/6.5/6.2, respectively (24h, HeLa cells).
+Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 96%/97%/97%/93%, respectively (HeLa cells).",Yangwode Jing,< 0.1 uM,> 93 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 1 uM,ester_to_amide,14,4,,,JQ1,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(OC(C)(C)C)=O)C=C1,NCCOCCOCC=O,PEG,10,4,7,958.608,No,,3MXF,JQ1,28595007,MZ4,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,"4, 24, 48",202.26
+840,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)C=C1,Active,Yes,"HeLa, HL60, MV4;11",5.596680000000004,"pEC50 for MV4;11 and HL60 cells: 7.57±0.03 and 6.66±0.05, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 8.1/8.6/7.0/7.4, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 98%/100%/100%/98%, respectively (HeLa cells).",Yangwode Jing,< 2.5 nM,> 98 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 0.1 uM,ester_to_amide,15,4,,,JQ1,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(OC(C)(C)C)=O)C=C1,NCCOCCOCCOCC=O,PEG,13,5,10,1002.661,No,,3MXF,JQ1,28595007,MZ1,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,"4, 24, 48",211.48999999999995
+841,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)C=C1,Active,No,"HeLa, HL60, MV4;11",5.613280000000005,"pEC50 for MV4;11 and HL60 cells: 6.91±0.04 and 5.90±0.05, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 8.4/8.0/6.5/6.7, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 99%/100%/99%/97%, respectively (HeLa cells).",Yangwode Jing,< 4 nM,> 97 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 0.4 uM,ester_to_amide,16,4,,,JQ1,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(OC(C)(C)C)=O)C=C1,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1046.714,No,,3MXF,JQ1,28595007,MZ2,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,"4, 24, 48",220.71999999999997
+842,CC1=NN=C2N1C3=C(C(C4=CC=C(C=C4)Cl)=N[C@H]2CC(NC5=CC=C(C=C5)OCCOCCOCCOCCNC6=C(C7=CC=C6)C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)C(C)=C(C)S3,Active,No,"HeLa, HL60, MV4;11",5.770260000000005,"pEC50 for MV4;11 and HL60 cells: 7.77±0.06 and 7.46±0.03, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 9.2/9.0/9.1/8.2, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 97%/100%/98%/83%, respectively (HeLa cells).",Yangwode Jing,< 1 nM,> 83 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,~ 32 nM,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCOCCOCCOCCOc1ccc(N)cc1,PEG,19,5,11,923.4489999999998,No,,3MXF,JQ1,28595007,ARV-825,No,,Reviewed,"O60885, P25440, Q15059",No,No,No,No,"4, 24, 48",204.67
+843,O=C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](O)C1)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)C4=CC=C(C5=CC6=C(N(C(C)=O)[C@@H](C)C[C@H]6NC7=CC=C(Cl)C=C7)C=C5)C=C4,Active,No,"HeLa, HL60, MV4;11",7.309320000000011,"pEC50 for MV4;11 and HL60 cells: 6.24±0.05 and 6.17±0.03, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 6.9/6.7/6.8/NA, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 94%/78%/74%/37%, respectively (HeLa cells).",Yangwode Jing,~ 0.1 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 1 uM,carboxilic_acid_to_amide,11,5,~ 30 nM,,I-BET726,O=C(O)C1=CC=C(C2=CC3=C(N(C(C)=O)[C@@H](C)C[C@H]3NC4=CC=C(Cl)C=C4)C=C2)C=C1,NCCOCCOCC=O,PEG,10,4,7,992.64,No,,4BJX,73B,28595007,MZP-61,No,,Reviewed,"O60885, Q15059",No,No,No,No,"4, 24, 48",191.53
+844,O=C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](O)C1)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)C4=CC=C(C5=CC6=C(N(C(C)=O)[C@@H](C)C[C@H]6NC7=CC=C(Cl)C=C7)C=C5)C=C4,Active,No,"HeLa, HL60, MV4;11",7.325920000000011,"pEC50 for MV4;11 and HL60 cells: 7.31±0.03 and 6.57±0.02, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 8.1/7.6/7.3/NA, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 98%/95%/91%/43%, respectively (HeLa cells).",Yangwode Jing,~ 7.9 nM,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 0.1 uM,carboxilic_acid_to_amide,12,5,~ 30 nM,,I-BET726,O=C(O)C1=CC=C(C2=CC3=C(N(C(C)=O)[C@@H](C)C[C@H]3NC4=CC=C(Cl)C=C4)C=C2)C=C1,NCCOCCOCCOCC=O,PEG,13,5,10,1036.693,No,,4BJX,73B,28595007,MZP-54,No,,Reviewed,"O60885, Q15059",No,No,No,No,"4, 24, 48",200.76
+845,O=C(NCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](O)C1)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)C4=CC=C(C5=CC6=C(N(C(C)=O)[C@@H](C)C[C@H]6NC7=CC=C(Cl)C=C7)C=C5)C=C4,Active,No,"HeLa, HL60, MV4;11",7.342520000000013,"pEC50 for MV4;11 and HL60 cells: 7.08±0.05 and 6.37±0.03, respectively. pDC50 for Brd4 short/Brd4 long/Brd3/Brd2: 8.1/7.5/7.7/NA, respectively (24h, HeLa cells). Dmax for Brd4 short/Brd4 long/Brd3/Brd2: 95%/93%/92%/26%, respectively (HeLa cells).",Yangwode Jing,~ 7.9 nM,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,~ 0.25 uM,carboxilic_acid_to_amide,13,5,,,I-BET726,O=C(O)C1=CC=C(C2=CC3=C(N(C(C)=O)[C@@H](C)C[C@H]3NC4=CC=C(Cl)C=C4)C=C2)C=C1,NCCOCCOCCOCCOCC=O,PEG,16,6,13,1080.7459999999999,No,,4BJX,73B,28595007,MZP-55,No,,Reviewed,"O60885, Q15059",No,No,No,No,"4, 24, 48",209.99
+846,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N4[C@H](C[C@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=O)C[C@H](O)C3,Active,No,"HeLa, HEK293, U2OS",3.5348400000000106,,Yangwode Jing,< 1 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_amide,16,6,,,Vh032,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3,O=CCOCCOCCOCCOCC=O,PEG,16,6,13,1091.364,No,,5LLI,6Z3,29018234,CM09,Yes,,Reviewed,P40337,Yes,No,No,No,"4, 10, 24, 48",260.18
+847,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N4[C@H](C[C@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=O)C[C@H](O)C3,Active,No,"HeLa, HEK293, U2OS",3.551440000000012,,Yangwode Jing,< 0.1 uM,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_amide,17,6,,,Vh032,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3,O=CCOCCOCCOCCOCCOCC=O,PEG,19,7,16,1135.417,No,,5LLI,6Z3,29018234,CM10,Yes,,Reviewed,P40337,Yes,No,No,No,"4, 10, 24, 48",269.41
+848,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N4[C@H](C[C@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=O)C[C@H](O)C3,Active,Yes,"HeLa, HEK293, U2OS",3.568040000000013,ITC/SEC/AlphaLISA assays were carried out for CM09/10/11 to confirm the formation of ternary complex in vitro.,Yangwode Jing,< 100 nM,100 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_amide,18,6,,,Vh032,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3,O=CCOCCOCCOCCOCCOCCOCC=O,PEG,22,8,19,1179.47,No,,5LLI,6Z3,29018234,CM11,Yes,,Reviewed,P40337,Yes,Yes,No,Yes,"4, 10, 24, 48",278.64
+849,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCOCCOCCOCCOCCOC3=C(CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C)=O)=O)C[C@H](O)C4)=O)C=CC(C5=C(C)N=CS5)=C3)[C@@H]6N(C([C@@H](C(C)(C)C)NC(C)=O)=O)C[C@@H](O)C6,Inactive,No,HeLa,4.332240000000012,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,"['amine_to_amide', 'aryl_O']",18,6,,,Vh032,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3,OCCOCCOCCOCCOCCO,PEG,16,6,13,1179.47,No,,5LLI,6Z3,29018234,CMP106,No,,Reviewed,P40337,No,No,No,No,10,278.64000000000004
+850,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOC4=C(CNC([C@H]5N(C([C@H](C(C)(C)C)NC(C)=O)=O)C[C@H](O)C5)=O)C=CC(C6=C(C)N=CS6)=C4)=O)=O)C[C@@H](O)C3,Inactive,No,HeLa,3.9501400000000126,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,"['amine_to_amide', 'aryl_O']",18,6,,,Vh032,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@H](O)C3,O=CCOCCOCCOCCOCCOCCO,PEG,19,7,16,1179.47,No,,5LLI,6Z3,29018234,CMP112,No,,Reviewed,P40337,No,No,No,No,10,278.64
+851,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1OCCOCCOCCOCCOCCOC3=C(CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C5(C#N)CC5)=O)=O)C[C@H](O)C4)=O)C=CC(C6=C(C)N=CS6)=C3)[C@@H]7N(C([C@@H](C(C)(C)C)NC(C8(C#N)CC8)=O)=O)C[C@@H](O)C7,Inactive,No,HeLa,4.900000000000013,,Yangwode Jing,,,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(C4(C#N)CC4)=O)=O)C[C@@H](O)C3,VHL,,,aryl_O,20,6,,,Vh298,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(C4(C#N)CC4)=O)=O)C[C@@H](O)C3,OCCOCCOCCOCCOCCO,PEG,16,6,13,1281.5659999999998,No,,5LLI,6Z3,29018234,CMP108,No,,Reviewed,P40337,No,No,No,No,10,326.21999999999997
+852,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCOC4=C(CNC([C@H]5N(C([C@H](C(C)(C)C)NC(C6(C#N)CC6)=O)=O)C[C@H](O)C5)=O)C=CC(C7=C(C)N=CS7)=C4)=O)=O)C[C@@H](O)C3,Inactive,No,HeLa,4.2340200000000126,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,19,6,,,Vh298,O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3N(C([C@@H](C(C)(C)C)NC(C4(C#N)CC4)=O)=O)C[C@@H](O)C3,OCCOCCOCCOCCOCCO,PEG,16,6,13,1230.5179999999998,No,,5LLI,6Z3,29018234,CMP113,No,,Reviewed,P40337,No,No,No,No,10,302.43
+853,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)OCCC5=CN(N=N5)CC(NC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O,Active,No,"MDA-MB-231, A549, A549/DDP, HUVEC",4.210900000000003,"EC50 of PROTAC1: 22.56±1.89uM/25.75±0.91uM/79.51±3.10uM/29.92±1.81uM for MDA-MB-231, A549, A549/DDP, HUVEC cells, respectively (MTT assay, 72h).",Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,13,3,,,CX-4945,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)O,CCc1cn(CC=O)nn1,Other,10,4,3,758.1510000000001,No,,3PE1 6HMB,3NG,30245235,1,No,,Reviewed,P68400,No,No,No,No,"24, 72",207.46999999999997
+854,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)OCCCC5=CN(N=N5)CC(NC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O,Active,Yes,"MDA-MB-231, A549, A549/DDP, HUVEC",4.601000000000004,"EC50 of PROTAC2: 17.36±1.43uM/31.19±2.95uM/57.55±4.20uM/34.39±2.99uM for MDA-MB-231, A549, A549/DDP, HUVEC cells, respectively (MTT assay, 72h).",Yangwode Jing,,> 80 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,13,3,,,CX-4945,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)O,CCCc1cn(CC=O)nn1,Other,11,4,4,772.1780000000001,No,,3PE1 6HMB,3NG,30245235,2,No,,Reviewed,P68400,No,No,No,Yes,"24, 72",207.46999999999997
+855,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)OCCCCCC5=CN(N=N5)CC(NC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O,Active,No,"MDA-MB-231, A549, A549/DDP, HUVEC",5.381200000000006,"EC50 of PROTAC3: 21.32±1.85uM/29.77±0.84uM/30.68±2.45uM/33.92±2.84uM for MDA-MB-231, A549, A549/DDP, HUVEC cells, respectively (MTT assay, 72h).",Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,13,3,,,CX-4945,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)O,CCCCCc1cn(CC=O)nn1,Other,13,4,6,800.2320000000001,No,,3PE1 6HMB,3NG,30245235,3,No,,Reviewed,P68400,No,No,No,No,"24, 72",207.46999999999997
+856,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)OCCOCC5=CN(N=N5)CC(NC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O,Active,No,"MDA-MB-231, A549, A549/DDP, HUVEC",4.185000000000004,"EC50 of PROTAC4: 31.67±2.97uM/36.46±0.52uM/>200uM/37.13±2.52uM for MDA-MB-231, A549, A549/DDP, HUVEC cells, respectively (MTT assay, 72h).",Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_ester,14,3,,,CX-4945,O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)O,CCOCc1cn(CC=O)nn1,Other,12,5,5,788.177,No,,3PE1 6HMB,3NG,30245235,4,No,,Reviewed,P68400,No,No,No,No,"24, 72",216.7
+857,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.90672000000001,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCC=O,PEG,16,6,11,933.054,No,,4CI3,Y70,30826187,7a,No,,Reviewed,Q96SW2,No,No,No,No,4,264.0
+858,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.9399200000000099,7b can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,17,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCCOCC=O,PEG,22,8,17,1021.1599999999999,Yes,,4CI3,Y70,30826187,7b,No,,Reviewed,Q96SW2,No,No,No,No,4,282.46
+859,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCCCCOCCOCCCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,Yes,"HeLa, HEK293",3.2639200000000104,Reported DC50 and Dmax above are in HeLa cells. DC50 for HEK293 cells: 230nM; Dmax for HEK293 cells: 98%. 14a can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,200 nM,88 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,16,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCCCCOCCOCCCCCOCC=O,non-PEG polyether,25,7,20,1061.2689999999996,Yes,,4CI3,Y70,30826187,14a,No,,Reviewed,Q96SW2,No,No,No,No,4,273.22999999999996
+860,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCCCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,2.450520000000008,14b can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCCCCCOCC=O,non-PEG polyether,17,5,12,945.109,Yes,,4CI3,Y70,30826187,14b,No,,Reviewed,Q96SW2,No,No,No,No,4,254.76999999999998
+861,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.9565200000000094,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,18,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCCOCCOCC=O,PEG,25,9,20,1065.2129999999997,No,,4CI3,Y70,30826187,14c,No,,Reviewed,Q96SW2,No,No,No,No,4,291.68999999999994
+862,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,1.0063200000000043,14d can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,21,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCCOCCOCCOCCOCCOCC=O,PEG,34,12,29,1197.3719999999994,Yes,,4CI3,Y70,30826187,14d,No,,Reviewed,Q96SW2,No,No,No,No,4,319.37999999999994
+863,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.9233200000000112,14e can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,16,6,1.2 uM,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCC=O,PEG,19,7,14,977.107,Yes,,4CI3,Y70,30826187,14e,No,,Reviewed,Q96SW2,No,No,No,No,4,273.22999999999996
+864,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@H](O)C6)=O)=O,Active,No,HeLa,1.7876200000000084,,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,16,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCC,PEG,15,5,10,1021.1349999999999,No,,4CI3,Y70,30826187,18a,No,,Reviewed,Q96SW2,No,No,No,No,4,273.23
+865,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@H](O)C6)=O)=O,Active,No,HeLa,1.8208200000000119,,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,18,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCCOCC,PEG,21,7,16,1109.241,No,,4CI3,Y70,30826187,18b,No,,Reviewed,Q96SW2,No,No,No,No,4,291.69
+866,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(CCCCOC4=CC(C5=C(N=CS5)C)=CC=C4CNC([C@@H]6C[C@H](CN6C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)O)=O)=O,Inactive,No,HeLa,2.9081200000000025,18c can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,13,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCCCC(=O)NCC,Alkane,9,2,4,931.0569999999998,Yes,,4CI3,Y70,30826187,18c,No,,Reviewed,Q96SW2,No,No,No,No,4,245.54
+867,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)COCCOCCOCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Active,No,HeLa,1.874520000000009,,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,16,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCS,PEG,16,5,11,1023.1759999999998,No,,4CI3,Y70,30826187,22a,No,,Reviewed,Q96SW2,No,No,No,No,4,263.99999999999994
+868,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)COCCOCCOCCOCCOCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Active,No,HeLa,1.9077200000000116,,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,18,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)COCCOCCOCCOCCOCCS,PEG,22,7,17,1111.282,No,,4CI3,Y70,30826187,22b,No,,Reviewed,Q96SW2,No,No,No,No,4,282.4599999999999
+869,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CCCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Inactive,No,HeLa,2.995020000000004,22c can degrade VHL at higher concentration. See Target UniprotID P40337 for details.,Yangwode Jing,,,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,VHL,,,amine_to_methylamine,13,6,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCNC(=O)CCCCS,Other,10,2,5,933.0980000000001,Yes,,4CI3,Y70,30826187,22c,No,,Reviewed,Q96SW2,No,No,No,No,4,236.30999999999995
+870,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.90672000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,15,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCOCCOCC=O,PEG,16,6,11,933.054,No,,6GFZ,EXE,30826187,7a,No,,Reviewed,P40337,No,No,No,No,4,264.0
+871,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,0.9399200000000099,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,17,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCOCCOCCOCCOCC=O,PEG,22,8,17,1021.1599999999999,No,,6GFZ,EXE,30826187,7b,No,,Reviewed,P40337,No,No,No,No,4,282.46
+872,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCCCCOCCOCCCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,3.2639200000000104,14a can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,16,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCCCCOCCOCCCCCOCC=O,non-PEG polyether,25,7,20,1061.2689999999996,Yes,,6GFZ,EXE,30826187,14a,No,,Reviewed,P40337,No,No,No,No,4,273.22999999999996
+873,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCCCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,2.450520000000008,14b can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,14,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCCCCCOCC=O,non-PEG polyether,17,5,12,945.109,Yes,,6GFZ,EXE,30826187,14b,No,,Reviewed,P40337,No,No,No,No,4,254.76999999999998
+874,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Inactive,No,HeLa,0.9565200000000094,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,18,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCOCCOCCOCCOCCOCC=O,PEG,25,9,20,1065.2129999999997,No,,6GFZ,EXE,30826187,14c,No,,Reviewed,P40337,No,No,No,No,4,291.68999999999994
+875,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,1.0063200000000043,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,21,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCOCCOCCOCCOCCOCCOCCOCCOCC=O,PEG,34,12,29,1197.3719999999994,No,,6GFZ,EXE,30826187,14d,No,,Reviewed,P40337,No,No,No,No,4,319.37999999999994
+876,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O,Active,No,HeLa,0.9233200000000112,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,16,6,,,Vh032,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,CCNC(=O)COCCOCCOCCOCC=O,PEG,19,7,14,977.107,No,,6GFZ,EXE,30826187,14e,No,,Reviewed,P40337,No,No,No,No,4,273.22999999999996
+877,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@H](O)C6)=O)=O,Inactive,No,HeLa,1.7876200000000084,18a can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCNC(=O)COCCOCCOCC,PEG,15,5,10,1021.1349999999999,Yes,,5LLI,6Z3,30826187,18a,No,,Reviewed,P40337,No,No,No,No,4,273.23
+878,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(COCCOCCOCCOCCOCCOC4=CC(C5=C(C)N=CS5)=CC=C4CNC([C@H]6N(C([C@@H](NC(C7(F)CC7)=O)C(C)(C)C)=O)C[C@H](O)C6)=O)=O,Inactive,No,HeLa,1.8208200000000119,18b can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCNC(=O)COCCOCCOCCOCCOCC,PEG,21,7,16,1109.241,Yes,,5LLI,6Z3,30826187,18b,No,,Reviewed,P40337,No,No,No,No,4,291.69
+879,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCCNC(CCCCOC4=CC(C5=C(N=CS5)C)=CC=C4CNC([C@@H]6C[C@H](CN6C([C@H](C(C)(C)C)NC(C7(CC7)F)=O)=O)O)=O)=O,Active,No,HeLa,2.9081200000000025,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCCCC(=O)NCC,Alkane,9,2,4,931.0569999999998,No,,5LLI,6Z3,30826187,18c,No,,Reviewed,P40337,No,No,No,No,4,245.54
+880,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)COCCOCCOCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Inactive,No,HeLa,1.874520000000009,22a can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCNC(=O)COCCOCCOCCS,PEG,16,5,11,1023.1759999999998,Yes,,5LLI,6Z3,30826187,22a,No,,Reviewed,P40337,No,No,No,No,4,263.99999999999994
+881,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)COCCOCCOCCOCCOCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Inactive,No,HeLa,1.9077200000000116,22b can degrade Cereblon at lower concentration. See Target UniprotID Q96SW2 for details.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCNC(=O)COCCOCCOCCOCCOCCS,PEG,22,7,17,1111.282,Yes,,5LLI,6Z3,30826187,22b,No,,Reviewed,P40337,No,No,No,No,4,282.4599999999999
+882,O=C(NCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)CCCCSC(C)([C@@H](C(N4C[C@@H](C[C@H]4C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)O)=O)NC(C7(CC7)F)=O)C,Active,No,HeLa,2.995020000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,6,,,Vh101,O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3O,CCNC(=O)CCCCS,Other,10,2,5,933.0980000000001,No,,5LLI,6Z3,30826187,22c,No,,Reviewed,P40337,No,No,No,No,4,236.30999999999995
+883,ClCC(N(CC1=CC=CC=C1)C2=CC=C(OC3=CC=C(OCCCCNC(C[C@@H](C4=NN=C(N4C5=C6C(C)=C(S5)C)C)N=C6C(C=C7)=CC=C7Cl)=O)C=C3)C=C2)=O,Active,Yes,"231MFP breast cancer cells, HeLa",9.729359999999998,,Yangwode Jing,,> 50 %,ClCC(N(CC1=CC=CC=C1)C2=CC=C(OC3=CC=C(OC)C=C3)C=C2)=O,RNF4,,,ester_to_amide,9,1,,0.54 uM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,CCCN,Alkane,4,1,1,821.8310000000002,"Yes, MT2A, ZC2HC1A, ZNF367, and ENSA were also down-regulated",,3MXF 3ONI,JQ1,31059647,CCW 28-3,Yes,,Reviewed,O60885,No,Yes,No,Yes,3,110.94
+884,O=C(N1C2C(NC(CC2)=O)=O)C(C=CC=C3NCCOCCOCCNC4=CC=CC(C(N5C6C(NC(CC6)=O)=O)=O)=C4C5=O)=C3C1=O,Active,Yes,MM1S,0.04620000000000385,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,12,4,,,Pomalidomide,NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O,CCOCCOCC,PEG,8,2,5,660.6400000000002,No,,4CI3,Y70,31157769,8,No,,Reviewed,Q96SW2,Yes,Yes,No,Yes,"3, 24, 48, 96",209.61999999999998
+885,ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCCCNC(C5=CC=C(C(OC=C6)=C6[C@@H]7C[C@@]([H])(O[C@]([C@@]8([H])C9[C@]%10(C)C(C=C[C@@]9(C)C(O8)=O)=O)([C@]%11(C)[C@@H]%10CC(OC)=O)[H])C%11=C7C)C=C5)=O)=O)C=C1,Active,Yes,231MFP,8.849460000000004,IC50: 0.24±0.12 uM,"Yangwode Jing, Nir London",,,CC1=C2[C@](O[C@]([C@@]3([H])C4[C@]5(C)C(C=C[C@@]4(C)C(O3)=O)=O)([C@]2(C)[C@@H]5CC(OC)=O)[H])(C[C@H]1C6=COC=C6)[H],RNF114,,,ester_to_amide,14,2,,0.24 uM,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCNC(=O)c1ccccc1,Other,13,3,4,1025.625,No,,3MXF,JQ1,31209351,XH2,Yes,,Reviewed,O60885,No,Yes,No,Yes,12,193.30999999999997
+886,O=C(NCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN([C@@H](CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,5.694660000000005,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCN,Other,19,7,7,907.4099999999996,No,,3MXF,JQ1,32128406,PHOTAC-I-1,No,,Reviewed,O60885,No,No,No,No,4,220.15999999999997
+887,O=C(NCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,6.0847600000000055,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCCN,Other,20,7,8,921.4369999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-2,No,,Reviewed,O60885,No,No,No,No,4,220.15999999999997
+888,O=C(NCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,Yes,RS4;11,6.474860000000007,"Light-activated PROTAC. The cis form is active. Tested Cullin-RING inhibitors (MLN4924), which proved that PROTAC is UPS-dependent.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,88.5 nM,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCCCN,Other,21,7,9,935.4639999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-3,No,,Reviewed,O60885,Yes,No,No,No,4,220.15999999999997
+889,O=C(NCCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,6.864960000000008,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCCCCN,Other,22,7,10,949.4909999999996,No,,3MXF,JQ1,32128406,PHOTAC-I-4,No,,Reviewed,O60885,No,No,No,No,4,220.15999999999997
+890,O=C(NCCCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,7.255060000000009,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,15,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCCCCCN,Other,23,7,11,963.5179999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-5,No,,Reviewed,O60885,No,No,No,No,4,220.15999999999997
+891,O=C(NCCNC(COC1=CC=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1)=O)C[C@@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,5.677460000000005,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,13,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCNC(=O)COc1ccc(N)cc1,Other,15,5,5,847.3579999999998,No,,3MXF,JQ1,32128406,PHOTAC-I-6,No,,Reviewed,O60885,No,No,No,No,4,201.7
+892,O=C(NCCCCNC(COC1=CC=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,6.457660000000007,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,13,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCCNC(=O)COc1ccc(N)cc1,Other,17,5,7,875.4119999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-7,No,,Reviewed,O60885,No,No,No,No,4,201.7
+893,O=C(NCCCCCCNC(COC1=CC=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,7.237860000000008,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,13,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCCCCCNC(=O)COc1ccc(N)cc1,Other,19,5,9,903.4659999999998,No,,3MXF,JQ1,32128406,PHOTAC-I-8,No,,Reviewed,O60885,No,No,No,No,4,201.7
+894,O=C(NCCNC(COC1=C(OC)C=C(/N=N/C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)C=C1OC)=O)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5,Active,No,RS4;11,5.334860000000004,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,16,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,COc1cc(N)cc(OC)c1OCC(=O)NCCN,Other,19,7,7,921.3929999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-9,No,,Reviewed,O60885,No,No,No,No,4,237.22999999999996
+895,O=C(NC1=CC=C(/N=N/C2=CC=C(NC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)C=C2)C=C1)C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6,Active,No,RS4;11,7.662460000000007,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,14,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,Nc1ccc(/N=N/c2ccc(NC(=O)CO)cc2)cc1,Other,20,6,4,909.3849999999998,No,,3MXF,JQ1,32128406,PHOTAC-I-10,No,,Reviewed,O60885,No,No,No,No,4,218.76999999999998
+896,O=C(NCC1=CC=C(/N=N/C2=CC=C(NC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)C=C2)C=C1)C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6,Active,No,RS4;11,7.340160000000007,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,14,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCc1ccc(/N=N/c2ccc(NC(=O)CO)cc2)cc1,Other,21,6,5,923.4119999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-11,No,,Reviewed,O60885,No,No,No,No,4,218.76999999999998
+897,O=C(NCCC1=CC=C(/N=N/C2=CC=C(NC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)C=C2)C=C1)C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6,Active,No,RS4;11,7.3826600000000075,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,14,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,NCCc1ccc(/N=N/c2ccc(NC(=O)CO)cc2)cc1,Other,22,6,6,937.4389999999997,No,,3MXF,JQ1,32128406,PHOTAC-I-12,No,,Reviewed,O60885,No,No,No,No,4,218.76999999999998
+898,O=C(NC1=CC=C2/N=N\C3=CC=C(NC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)C=C3CCC2=C1)C[C@H]7C8=NN=C(C)N8C9=C(C(C)=C(C)S9)C(C%10=CC=C(Cl)C=C%10)=N7,Active,No,RS4;11,7.761060000000008,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,ester_to_amide,14,3,,,JQ1,Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2,Nc1c-c2c(-cc1)/N=N\c1ccc(NC(=O)CO)cc1CC2,Other,22,6,2,935.4229999999995,No,,3MXF,JQ1,32128406,PHOTAC-I-13,No,,Reviewed,O60885,No,No,No,No,4,218.76999999999998
+899,O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(OCC(NC3=CC=C(/N=N/C4=CC=C(NC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)C=C4)C=C3)=O)=C2)CCC8=CC=C(OC)C(OC)=C8,Active,No,RS4;11,8.158900000000006,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,16,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,O=C(CO)Nc1ccc(/N=N/c2ccc(NC(=O)CO)cc2)cc1,Other,24,8,6,1092.1719999999993,No,,,,32128406,PHOTAC-II-6,No,,Reviewed,P62942,No,No,No,No,4,267.07
+900,O=C(NCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)COc5cc([C@@H](CCc6cc(OC)c(OC)cc6)OC([C@@H]7CCCCN7C(C(C(C)(C)CC)=O)=O)=O)ccc5,Active,No,RS4;11,6.581200000000007,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,17,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,COc1cc(N)cc(OC)c1OCC(=O)NCCCNC(=O)CO,Other,24,9,10,1104.2239999999995,No,,,,32128406,PHOTAC-II-1,No,,Reviewed,P62942,No,No,No,No,4,268.4599999999999
+901,O=C(NCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)COc5cc([C@@H](CCc6cc(OC)c(OC)cc6)OC([C@@H]7CCCCN7C(C(C(C)(C)CC)=O)=O)=O)ccc5,Inactive,No,RS4;11,6.971300000000007,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,17,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,COc1cc(N)cc(OC)c1OCC(=O)NCCCCNC(=O)CO,Other,25,9,11,1118.2509999999995,No,,,,32128406,PHOTAC-II-2,No,,Reviewed,P62942,No,No,No,No,4,268.4599999999999
+902,O=C(NCCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)COc5cc([C@@H](CCc6cc(OC)c(OC)cc6)OC([C@@H]7CCCCN7C(C(C(C)(C)CC)=O)=O)=O)ccc5,Inactive,No,RS4;11,7.361400000000008,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,17,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,COc1cc(N)cc(OC)c1OCC(=O)NCCCCCNC(=O)CO,Other,26,9,12,1132.2779999999996,No,,,,32128406,PHOTAC-II-3,No,,Reviewed,P62942,No,No,No,No,4,268.4599999999999
+903,O=C(NCCCCCCNC(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)=O)COc5cc([C@@H](CCc6cc(OC)c(OC)cc6)OC([C@@H]7CCCCN7C(C(C(C)(C)CC)=O)=O)=O)ccc5,Inactive,No,RS4;11,7.751500000000008,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,17,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,COc1cc(N)cc(OC)c1OCC(=O)NCCCCCCNC(=O)CO,Other,27,9,13,1146.3049999999994,No,,,,32128406,PHOTAC-II-4,No,,Reviewed,P62942,No,No,No,No,4,268.4599999999999
+904,O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(OCC(NCCNC(COC3=CC=C(/N=N\C4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)C=C3)=O)=O)=C2)CCC7=CC=C(OC)C(OC)=C7,Active,No,RS4;11,6.173900000000006,Light-activated PROTAC. The cis form is active.,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_ether,15,3,,,SLF,CCC(C)(C)C(=O)C(=O)N1CCCC[C@H]1C(=O)OC(CCc1ccc(OC)c(OC)c1)c1cccc(N)c1,Nc1ccc(OCC(=O)NCCNC(=O)CO)cc1,Other,19,7,7,1030.1449999999995,No,,,,32128406,PHOTAC-II-5,No,,Reviewed,P62942,No,No,No,No,4,249.99999999999997
+905,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCOC4=CC=C(/N=N/C5=CC=C(C(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)C=C5)C=C4)CC3)=C2)S1)NC9=C(C)C=CC=C9Cl,Active,No,K562,7.828940000000008,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,O=Cc1ccc(/N=N/c2ccccc2)cc1,Other,16,3,3,953.4859999999998,No,,2GQG,1N1,32153174,Azo-PROTAC-2C,No,,Reviewed,P00519,No,No,No,No,24,215.80999999999997
+906,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCOC4=CC=C(/N=N/C5=CC=C(C(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)C=C5)C=C4)CC3)=C2)S1)NC9=C(C)C=CC=C9Cl,Active,No,K562,8.219040000000007,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,15,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,COc1ccc(/N=N/c2ccc(C=O)cc2)cc1,Other,18,4,4,967.5129999999997,No,,2GQG,1N1,32153174,Azo-PROTAC-3C,No,,Reviewed,P00519,No,No,No,No,24,215.80999999999997
+907,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCCOC4=CC=C(/N=N/C5=CC=C(C(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)C=C5)C=C4)CC3)=C2)S1)NC9=C(C)C=CC=C9Cl,Active,Yes,"K562, A549, HCT116, MCF-7, HEK293T",8.609140000000005,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,28 nM,hydroxyl_to_carbon,15,4,,68 nM,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOc1ccc(/N=N/c2ccc(C=O)cc2)cc1,Other,19,4,5,981.5399999999997,No,,2GQG,1N1,32153174,Azo-PROTAC-4C,No,,Reviewed,P00519,Yes,Yes,No,No,24,215.80999999999997
+908,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCCCOC4=CC=C(/N=N/C5=CC=C(C(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)C=C5)C=C4)CC3)=C2)S1)NC9=C(C)C=CC=C9Cl,Inactive,No,K562,8.999240000000004,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,15,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCOc1ccc(/N=N/c2ccc(C=O)cc2)cc1,Other,20,4,6,995.5669999999998,No,,2GQG,1N1,32153174,Azo-PROTAC-5C,No,,Reviewed,P00519,No,No,No,No,24,215.80999999999997
+909,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCCCCOC4=CC=C(/N=N/C5=CC=C(C(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)C=C5)C=C4)CC3)=C2)S1)NC9=C(C)C=CC=C9Cl,Inactive,No,K562,9.38934,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,15,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCCCOc1ccc(/N=N/c2ccc(C=O)cc2)cc1,Other,21,4,7,1009.5939999999998,No,,2GQG,1N1,32153174,Azo-PROTAC-6C,No,,Reviewed,P00519,No,No,No,No,24,215.80999999999997
+910,O=C(N/N=C/C1=CC=C(OCCOCCOCCN2N=NC(CNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=C2)C=C1)CCCCCCC(NO)=O,Active,No,MM1S,1.6997000000000053,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,5,,,AB3,O=C(N/N=C/C1=CC=C(OC)C=C1)CCCCCCC(NO)=O,COCCOCCn1cc(C)nn1,Other,13,5,6,775.8199999999998,No,,5WGL,AH4,32292566,1,No,,Reviewed,Q9UBN7,No,No,No,No,6,244.76999999999998
+911,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3NCC4=CN(N=N4)CCCCCOC5=CC=C(NC(N(CCCC)CC6=CC=C(C(NO)=O)C=C6)=O)C=C5,Active,No,MM1S,4.493900000000003,,Yangwode Jing,2.2 nM,86 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,12,5,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,Cc1cn(CCCCCO)nn1,Other,12,4,5,779.855,Yes,,5G0I 5G0J,N4R,32292566,2,No,,Reviewed,Q9UBN7,No,No,No,No,"0.5, 1, 2, 4, 6",217.19
+912,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,6.2641200000000055,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCO)nn1,Other,14,5,7,965.191,No,,5G0I 5G0J,N4R,32292566,3a,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+913,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,6.654220000000007,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCO)nn1,Other,15,5,8,979.2180000000001,No,,5G0I 5G0J,N4R,32292566,3b,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+914,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,7.044320000000007,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCO)nn1,Other,16,5,9,993.2450000000001,No,,5G0I 5G0J,N4R,32292566,3c,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+915,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,7.434420000000007,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCO)nn1,Other,17,5,10,1007.2720000000002,No,,5G0I 5G0J,N4R,32292566,3d,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+916,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,7.824520000000008,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCO)nn1,Other,18,5,11,1021.2990000000001,No,,5G0I 5G0J,N4R,32292566,3e,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+917,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,8.214620000000007,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCO)nn1,Other,19,5,12,1035.326,No,,5G0I 5G0J,N4R,32292566,3f,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+918,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,8.604720000000006,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCCO)nn1,Other,20,5,13,1049.353,No,,5G0I 5G0J,N4R,32292566,3g,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+919,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,8.994820000000002,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCCCO)nn1,Other,21,5,14,1063.3799999999999,No,,5G0I 5G0J,N4R,32292566,3h,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+920,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,9.384920000000003,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCCCCO)nn1,Other,22,5,15,1077.4069999999997,No,,5G0I 5G0J,N4R,32292566,3i,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+921,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,Yes,MM1S; Mouse 4935 cells,9.77502,,Yangwode Jing,7.1 nM,90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCCCCCO)nn1,Other,23,5,16,1091.434,No,,5G0I 5G0J,N4R,32292566,3j,No,,Reviewed,Q9UBN7,No,Yes,No,Yes,"0.5, 1, 2, 4, 6",233.23999999999995
+922,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCC2=CN(CCCCCCCCCCCCOC3=CC=C(NC(N(CCCC)CC4=CC=C(C(NO)=O)C=C4)=O)C=C3)N=N2)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5,Active,No,MM1S,10.165119999999996,,Yangwode Jing,11 nM,89 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCCCCCCCCCCCO)nn1,Other,24,5,17,1105.4609999999998,No,,5G0I 5G0J,N4R,32292566,3k,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999995
+923,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCC4=CN(N=N4)CCCOC5=CC=C(C=C5)NC(N(CC6=CC=C(C=C6)C(NO)=O)CCCC)=O)=O)C(C)(C)C)=O,Inactive,No,MM1S,5.874020000000003,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCc1cn(CCCO)nn1,Other,13,5,6,951.1639999999999,No,,5G0I 5G0J,N4R,32292566,WH174,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999998
+924,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCC4=CN(N=N4)CCCOC5=CC=C(C=C5)NC(N(CC6=CC=C(C=C6)C(NO)=O)CCCC)=O)=O)C(C)(C)C)=O,Inactive,No,MM1S,6.264120000000005,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,13,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCc1cn(CCCO)nn1,Other,14,5,7,965.1909999999998,No,,5G0I 5G0J,N4R,32292566,WH167,No,,Reviewed,Q9UBN7,No,No,No,No,6,233.23999999999998
+925,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCC4=CN(CCOCCOC5=CC=C(C=C5)NC(N(CC6=CC=C(C=C6)C(NO)=O)CCCC)=O)N=N4)=O)C(C)(C)C)=O,Inactive,No,MM1S,6.280720000000004,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,14,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCOCCO)nn1,Other,17,6,10,1009.2439999999997,No,,5G0I 5G0J,N4R,32292566,WH221,No,,Reviewed,Q9UBN7,No,No,No,No,6,242.46999999999997
+926,O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCC4=CN(CCOCCOCCOC5=CC=C(C=C5)NC(N(CC6=CC=C(C=C6)C(NO)=O)CCCC)=O)N=N4)=O)C(C)(C)C)=O,Inactive,No,MM1S,6.297320000000005,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aryl_O,15,6,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,O=CCCCCc1cn(CCOCCOCCO)nn1,Other,20,7,13,1053.2969999999996,No,,5G0I 5G0J,N4R,32292566,WH212,No,,Reviewed,Q9UBN7,No,No,No,No,6,251.7
+927,COC1=C(C=C(C(N(CCN(CCOCCOCC(NC2=CC=CC3=C2CN(C3=O)C4CCC(NC4=O)=O)=O)C)C)=C1)NC(C=C)=O)NC5=NC=CC(C6=CN(C7=C6C=CC=C7)C)=N5,Active,No,PC9; HCC827; H1975,4.3129000000000035,"EC50: 1.425±0.052uM, 1.874±0.098uM, 1.388±0.556uM for PC9/HCC827/H1975 cells, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,1.425 uM,aliphatic_CC,14,4,,,Osimertinib,COC1=C(C=C(C(N(CCN(C)C)C)=C1)NC(C=C)=O)NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2,COCCOCC=O,PEG,8,3,5,872.9839999999998,,,3IKA,0UN,32317208,16a,No,,Reviewed,P00533,No,No,No,No,"6, 24",201.58999999999997
+928,COC1=C(C=C(C(N(CCN(CCOCCOCCOCC(NC2=CC=CC3=C2CN(C3=O)C4CCC(NC4=O)=O)=O)C)C)=C1)NC(C=C)=O)NC5=NC=CC(C6=CN(C7=C6C=CC=C7)C)=N5,Active,No,PC9; HCC827; H1975,4.329500000000005,"EC50: 1.117±0.105uM, 1.611±0.139uM, 1.698±0.614uM for PC9/HCC827/H1975 cells, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,1.117 uM,aliphatic_CC,15,4,,,Osimertinib,COC1=C(C=C(C(N(CCN(C)C)C)=C1)NC(C=C)=O)NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2,COCCOCCOCC=O,PEG,11,4,8,917.0369999999999,No,,3IKA,0UN,32317208,16b,No,,Reviewed,P00533,No,No,No,No,"6, 24",210.82
+929,COC1=C(C=C(C(N(CCN(CCOCCOCCOCCOCC(NC2=CC=CC3=C2CN(C3=O)C4CCC(NC4=O)=O)=O)C)C)=C1)NC(C=C)=O)NC5=NC=CC(C6=CN(C7=C6C=CC=C7)C)=N5,Active,Yes,PC9; HCC827; H1975,4.346100000000006,"EC50: 0.413±0.087uM, 1.344±0.112uM, 0.657±0.008uM for PC9/HCC827/H1975 cells, respectively.",Yangwode Jing,0.161 uM,68 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,0.413 uM,aliphatic_CC,16,4,,,Osimertinib,COC1=C(C=C(C(N(CCN(C)C)C)=C1)NC(C=C)=O)NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2,COCCOCCOCCOCC=O,PEG,14,5,11,961.0899999999997,No,,3IKA,0UN,32317208,16c,No,,Reviewed,P00533,No,No,No,Yes,"1, 3, 6, 12, 24, 48",220.04999999999995
+930,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3OCC(NCCOCCOCCOCCNC(C4=CC=C(C5=CC=C(F)C(C)=C5)C(N6CCC(C7=C(C)N=CN7)CC6)=C4)=O)=O,Active,No,"T47D, BT474, MDAMB231, MCF7, HS578T, LS180, HCT116, HCT15, DLD1, SW480, LOVO, SW620, HEL, KCL22, THP1, K562, ML2, NOMO1, MONOMAC6, MOLM13, LAMA84, SHI1, MV411, KU812, KG1, KBM7, HL60, BV173, HUH7, NCIH460, A549, NCIH2228, PC9, NCIH446, HELA, T98G, MCF10A, HAP1, DU145, PC3, LNCaP, A375, LOXIMVI",3.592640000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,4,,,carboxy-w9A,FC1=CC=C(C2=CC=C(C(O)=O)C=C2N3CCC(C4=C(C)N=CN4)CC3)C=C1C,NCCOCCOCCOCCNC(=O)CO,PEG,17,7,12,881.959,"Possible, since d9A-2 was reported.",,,,32386596,d9A-1,No,,Reviewed,P19634,No,No,No,No,8,210.59
+931,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3OCC(NCCOCCOCCOCCOCCNC(C4=CC=C(C5=CC=C(F)C(C)=C5)C(N6CCC(C7=C(C)N=CN7)CC6)=C4)=O)=O,Active,Yes,"T47D, BT474, MDAMB231, MCF7, HS578T, LS180, HCT116, HCT15, DLD1, SW480, LOVO, SW620, HEL, KCL22, THP1, K562, ML2, NOMO1, MONOMAC6, MOLM13, LAMA84, SHI1, MV411, KU812, KG1, KBM7, HL60, BV173, HUH7, NCIH460, A549, NCIH2228, PC9, NCIH446, HELA, T98G, MCF10A, HAP1, DU145, PC3, LNCaP, A375, LOXIMVI",3.609240000000006,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,< 0.1 uM,carboxilic_acid_to_amide,13,4,,,carboxy-w9A,FC1=CC=C(C2=CC=C(C(O)=O)C=C2N3CCC(C4=C(C)N=CN4)CC3)C=C1C,NCCOCCOCCOCCOCCNC(=O)CO,PEG,20,8,15,926.0119999999998,"Yes, could also degrade SLC9A2, SLC9A4, SLC9A7, SLC9B1",,,,32386596,d9A-2,No,,Reviewed,P19634,No,No,No,Yes,"8, 72",219.82000000000002
+932,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3OCC(NCCOCCCOCCCOCCNC(C4=CC=C(C5=CC=C(F)C(C)=C5)C(N6CCC(C7=C(C)N=CN7)CC6)=C4)=O)=O,Active,No,"T47D, BT474, MDAMB231, MCF7, HS578T, LS180, HCT116, HCT15, DLD1, SW480, LOVO, SW620, HEL, KCL22, THP1, K562, ML2, NOMO1, MONOMAC6, MOLM13, LAMA84, SHI1, MV411, KU812, KG1, KBM7, HL60, BV173, HUH7, NCIH460, A549, NCIH2228, PC9, NCIH446, HELA, T98G, MCF10A, HAP1, DU145, PC3, LNCaP, A375, LOXIMVI",4.3728400000000045,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,4,,,carboxy-w9A,FC1=CC=C(C2=CC=C(C(O)=O)C=C2N3CCC(C4=C(C)N=CN4)CC3)C=C1C,NCCOCCCOCCCOCCNC(=O)CO,non-PEG polyether,19,7,14,910.0129999999999,"Possible, since d9A-2 was reported",,,,32386596,d9A-3,No,,Reviewed,P19634,No,No,No,No,8,210.59
+933,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3OCC(NCCOCCOCCNC(C4=CC=C(C5=CC=C(F)C(C)=C5)C(N6CCC(C7=C(C)N=CN7)CC6)=C4)=O)=O,Inactive,No,"T47D, BT474, MDAMB231, MCF7, HS578T, LS180, HCT116, HCT15, DLD1, SW480, LOVO, SW620, HEL, KCL22, THP1, K562, ML2, NOMO1, MONOMAC6, MOLM13, LAMA84, SHI1, MV411, KU812, KG1, KBM7, HL60, BV173, HUH7, NCIH460, A549, NCIH2228, PC9, NCIH446, HELA, T98G, MCF10A, HAP1, DU145, PC3, LNCaP, A375, LOXIMVI",3.5760400000000034,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,,carboxy-w9A,FC1=CC=C(C2=CC=C(C(O)=O)C=C2N3CCC(C4=C(C)N=CN4)CC3)C=C1C,NCCOCCOCCNC(=O)CO,PEG,14,6,9,837.906,Possible,,,,32386596,d9A-4,No,,Reviewed,P19634,No,No,No,No,8,201.35999999999999
+934,O=C(N(C1=O)C2CCC(NC2=O)=O)C3=C1C=CC=C3OCC(NCCCCCCNC(C4=CC=C(C5=CC=C(F)C(C)=C5)C(N6CCC(C7=C(C)N=CN7)CC6)=C4)=O)=O,Inactive,No,"T47D, BT474, MDAMB231, MCF7, HS578T, LS180, HCT116, HCT15, DLD1, SW480, LOVO, SW620, HEL, KCL22, THP1, K562, ML2, NOMO1, MONOMAC6, MOLM13, LAMA84, SHI1, MV411, KU812, KG1, KBM7, HL60, BV173, HUH7, NCIH460, A549, NCIH2228, PC9, NCIH446, HELA, T98G, MCF10A, HAP1, DU145, PC3, LNCaP, A375, LOXIMVI",5.103240000000005,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,9,4,,,carboxy-w9A,FC1=CC=C(C2=CC=C(C(O)=O)C=C2N3CCC(C4=C(C)N=CN4)CC3)C=C1C,NCCCCCCNC(=O)CO,Alkane,12,4,7,805.9079999999999,Possible,,,,32386596,d9A-5,No,,Reviewed,P19634,No,No,No,No,8,182.9
+935,O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCOCCOCCNC(CCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)=O)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Inactive,No,NCI-H2030,6.273800000000012,,Yangwode Jing,,~ 30 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,17,4,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,CC(=O)NCCOCCOCCC=O,PEG,14,5,9,1233.9099999999996,No,,6UT0,M1X,32875077,LC-1,No,,Reviewed,P01116,No,No,No,No,"24, 72",248.01999999999998
+936,O=C([C@H]1N(C([C@@H](NC(CCOCCCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Active,Yes,5W1573; NCI-H2030; NCI-H358; HCT116; MIA-PaCa-2,7.14100000000001,"EC50/DC50/Dmax reported above were obtained using NCI-H2030 cells. DC50: 0.25~0.76uM; Dmax: ~75%-90%, specific value depends on the cell line.",Yangwode Jing,0.59 uM,~ 80 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,3.8 uM,aliphatic_CC,15,3,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,CCOCCC=O,Other,7,2,4,1132.8049999999994,No,,6UT0,M1X,32875077,LC-2,No,,Reviewed,P01116,Yes,No,No,Yes,"24, 72",209.69
+937,O=C([C@H]1N(C([C@@H](NC(CCNC(CCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Active,No,NCI-H2030,6.24060000000001,,Yangwode Jing,6.4 uM,~ 85 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,4,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,CC(=O)NCCC=O,Other,8,3,3,1145.8039999999994,No,,6UT0,M1X,32875077,LC-3,No,,Reviewed,P01116,No,No,No,No,"24, 72",229.55999999999995
+938,O=C([C@H]1N(C([C@@H](NC(CCOCCCCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Active,No,SW1573,7.53110000000001,,Yangwode Jing,0.88 uM,~ 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,15,3,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,CCCOCCC=O,Other,8,2,5,1146.8319999999994,No,,6UT0,M1X,32875077,LC-4,No,,Reviewed,P01116,No,No,No,No,"24, 72",209.69
+939,O=C([C@H]1N(C([C@@H](NC(CCOCCOCCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Active,No,SW1573,6.767500000000011,,Yangwode Jing,> 10 uM,~ 50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,3,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,COCCOCCC=O,PEG,9,3,6,1162.8309999999992,No,,6UT0,M1X,32875077,LC-5,No,,Reviewed,P01116,No,No,No,No,"24, 72",218.91999999999996
+940,O=C([C@H]1N(C([C@@H](NC(CCOCCNC(CCN2[C@H](COC3=NC(N4C[C@H](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8,Inactive,No,NCI-H2030,6.25720000000001,,Yangwode Jing,,~ 35 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,aliphatic_CC,16,4,~ 0.10 uM,,MRTX849,N#CC[C@@H]1N(C(C(F)=C)=O)CCN(C2=C3C(CN(C4=C5C(Cl)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1,CC(=O)NCCOCCC=O,Other,11,4,6,1189.8569999999993,No,,6UT0,M1X,32875077,LC-6,No,,Reviewed,P01116,No,No,No,No,"24, 72",238.78999999999996
+941,O=C(NCCOCCOCCNC1=CC=C(C=C1)C2=NC3=CC=C(C)C=C3S2)[C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O,Active,Yes,Fibroblasts from patients; HeLa,4.294820000000002,,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,aliphatic_CC,9,5,,,BTA,CC1=CC=C2C(SC(C3=CC=C(NC)C=C3)=N2)=C1,COCCOCCN,PEG,8,3,5,661.8690000000001,No,,,,28703441,1,No,,Reviewed,P42858,Yes,No,No,Yes,"24, 48",147.83
+942,O=C(NCCOCCOCCOC1=CC(SC(/N=N/C2=CC=C(N(C)C)C=C2)=N3)=C3C=C1)[C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O,Active,No,Fibroblasts from patients; HeLa,4.767700000000003,,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,aliphatic_CC,12,4,,,PDB,CN(C)C1=CC=C(/N=N/C2=NC3=C(S2)C=C(OC)C=C3)C=C1,COCCOCCN,PEG,8,3,5,719.9090000000001,No,,,,28703441,2,No,,Reviewed,P42858,No,No,No,No,"24, 48",172.99
+943,O=C([C@H]1N(C[C@@H](C1)O)C([C@@H](NC(CCCC(N2CCC(C3=C(C)C=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C(OC(C)C)=C3)CC2)=O)=O)C(C)(C)C)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C,Active,Yes,SU-DHL-1; H3122,9.012240000000004,"EC50: 0.058uM/0.18uM/>10uM for SU-DHL-1/H3122/A549 cells, respectively.",Yangwode Jing,,> 90 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,0.058 uM,amine_to_amide,14,5,7 nM,0.11 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,O=CCCCC=O,Alkane,7,2,4,1084.8069999999996,No,,4MKC,4MK,30274779,TD-004,No,,Reviewed,Q9UM73,No,No,No,Yes,16,225.14999999999998
+944,O=C([C@@H]1N(C([C@H](NC(CCCCCC(N2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C=C3C)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6,Active,No,SU-DHL-1,9.792439999999997,,Yangwode Jing,,> 95 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_amide,14,5,7 nM,0.14 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,O=CCCCCCC=O,Alkane,9,2,6,1112.8609999999996,No,,4MKC,4MK,30274779,TD-016,No,,Reviewed,Q9UM73,No,No,No,No,16,225.14999999999998
+945,O=C([C@@H]1N(C([C@H](NC(CCCCN2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C=C3C)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6,Active,No,SU-DHL-1,9.485640000000004,,Yangwode Jing,,> 50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,14,5,7 nM,0.032 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,CCCCC=O,Alkane,6,1,3,1070.8239999999994,No,,4MKC,4MK,30274779,TD-009,No,,Reviewed,Q9UM73,No,No,No,No,16,208.07999999999998
+946,O=C([C@H]1N(C([C@@H](NC(COCCN2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C=C3C)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6,Active,No,SU-DHL-1,8.331940000000008,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,5,7 nM,0.089 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,CCOCC=O,Other,6,2,3,1072.7959999999994,No,,4MKC,4MK,30274779,TD-013,No,,Reviewed,Q9UM73,No,No,No,No,16,217.30999999999995
+947,O=C([C@@H]1N(C([C@H](NC(COCCCN2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C=C3C)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6,Active,No,SU-DHL-1,8.722040000000005,,Yangwode Jing,,> 50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,15,5,7 nM,0.02 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,CCCOCC=O,Other,7,2,4,1086.8229999999994,No,,4MKC,4MK,30274779,TD-020,No,,Reviewed,Q9UM73,No,No,No,No,16,217.30999999999995
+948,O=C([C@@H]1N(C([C@@H](C(C)(C)C)NC(COCCOCCOCCN2CCC(C3=CC(OC(C)C)=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C=C3C)CC2)=O)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6,Active,No,SU-DHL-1; H3122,8.36514000000001,,Yangwode Jing,,> 50 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,amine_to_methylamine,17,5,7 nM,0.016 uM,LDK378,O=S(C1=CC=CC=C1NC2=NC(NC3=CC(C)=C(C4CCNCC4)C=C3OC(C)C)=NC=C2Cl)(C(C)C)=O,CCOCCOCCOCC=O,PEG,12,4,9,1160.9019999999996,No,,4MKC,4MK,30274779,TD-002,No,,Reviewed,Q9UM73,No,No,No,No,16,235.76999999999998
+949,O=C(NO)C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1,Active,Yes,IgEMM; hTERT-RPE1; HeLa; Jurkat; RPMI8226; MM.1S,3.000600000000004,,Yangwode Jing,3.8 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,1.21 uM,aliphatic_CC,13,5,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,CCOCCOCCn1ccnn1,PEG,13,5,7,795.8540000000003,No,,5G0J 5G0I,N4R,30603959,NP8,No,,Reviewed,Q9UBN7,Yes,Yes,No,Yes,"2, 4, 6, 8, 24",226.42
+950,O=C(NO)C1=CC=C(CN(CCCCC2=CN(CCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1,Active,No,HeLa,2.9840000000000027,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,5,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,CCOCCn1ccnn1,PEG,10,4,4,751.8010000000002,No,,5G0J 5G0I,N4R,30603959,NP6,No,,Reviewed,Q9UBN7,No,No,No,No,24,217.18999999999997
+951,O=C(NO)C1=CC=C(CN(CCCCC2=CN(CCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1,Active,No,HeLa,3.017200000000006,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,5,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,CCOCCOCCOCCn1ccnn1,PEG,16,6,10,839.907,No,,5G0J 5G0I,N4R,30603959,NP9,No,,Reviewed,Q9UBN7,No,No,No,No,24,235.64999999999995
+952,O=C(NO)C1=CC=C(CN(CCCCC2=CN(CCOCCOCCOCCOCCNC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1,Active,No,HeLa,3.0338000000000074,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,5,,,Nexturastat A (Next-A),O=C(N(CCCC)CC1=CC=C(C(NO)=O)C=C1)NC2=CC=CC=C2,CCOCCOCCOCCOCCn1ccnn1,PEG,19,7,13,883.96,No,,5G0J 5G0I,N4R,30603959,NP10,No,,Reviewed,Q9UBN7,No,No,No,No,24,244.87999999999997
+953,O=C(NCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4,Active,No,Jurkat,2.324320000000003,,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,16,4,,,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CC(=O)NCCOCCN,PEG,10,4,5,847.9339999999996,No,,5L2I,LQQ,30802347,BSJ-03-006,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,230.15999999999997
+954,O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4,Active,No,Jurkat,2.340920000000004,,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,17,4,,,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CC(=O)NCCOCCOCCN,PEG,13,5,8,891.9869999999995,No,,5L2I,LQQ,30802347,BSJ-03-007,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,239.39
+955,O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4,Active,No,Jurkat,3.868120000000003,"IC50: 77nM/27.6nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,4,,77 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CC(=O)NCCCCCCN,Alkane,11,3,6,859.9889999999996,No,,5L2I,LQQ,30802347,BSJ-03-008,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,220.92999999999995
+956,O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4,Active,No,Jurkat,2.3575200000000054,"IC50: 137nM/39nM for CDK4/CDK6, respectively; Show selective degradation of CDK6 (therefore active for CDK6 and inactive for CDK4).",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,18,4,,39 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CC(=O)NCCOCCOCCOCCN,PEG,16,6,11,936.0399999999993,"Yes, can also degrade IKZF1/3",,5L2I,LQQ,30802347,YKL-06-102,No,,Reviewed,Q00534,No,No,No,No,4,248.61999999999995
+957,O=C(NCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4,Active,No,Jurkat,2.390720000000008,,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,20,4,,,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CC(=O)NCCOCCOCCOCCOCCOCCN,PEG,22,8,17,1024.145999999999,No,,5L2I,LQQ,30802347,BSJ-03-009,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,267.08
+958,O=C(NCCOCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,Jurkat,2.3244200000000053,"IC50: 106nM/37.7nM for CDK4/CDK6, respectively. Show selectivity on CDK6 (therefore inactive for CDK4 and active for CDK6).",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,18,3,,37.7 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CCOCCOCCOCCNC(=O)CO,PEG,16,6,11,937.0239999999994,No,,5L2I,LQQ,30802347,BSJ-03-123,Yes,,Reviewed,Q00534,No,No,No,No,4,245.82
+959,O=C(NCCCCCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,Jurkat,4.615220000000004,,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CCCCCCCCNC(=O)CO,Alkane,13,3,8,889.0269999999997,No,,5L2I,LQQ,30802347,BSJ-03-124,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,218.12999999999997
+960,O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,Yes,Jurkat; Molt4; Granta-519; Mino; Jeko; Rec1; Maver,3.054820000000001,"IC50: 25.7nM/7.57nM for CDK4/CDK6, respectively. BSJ-02-162 is capable of degrading both CDK4 and CDK6.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,25.7 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CCCCNC(=O)CO,Alkane,9,3,4,832.919,"Yes, can also degrade IKZF1/3",,5L2I,LQQ,30802347,BSJ-02-162,Yes,,Reviewed,"P11802, Q00534",No,No,No,No,"4, 24, 72, 96",218.12999999999997
+961,O=C(NCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,Jurkat,2.664720000000001,,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CCCNC(=O)CO,Alkane,8,3,3,818.8919999999999,No,,5L2I,LQQ,30802347,BSJ-03-135,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,218.12999999999997
+962,O=C(NCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,Jurkat,2.2746200000000005,"IC50: 69.6nM/34.6nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,69.6 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,CCNC(=O)CO,Alkane,7,3,2,804.865,No,,5L2I,LQQ,30802347,BSJ-03-189,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,218.12999999999997
+963,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N4CCN(C5=CC=C(NC6=NC=C(C(C)=C(C(C)=O)C(N7C8CCCC8)=O)C7=N6)N=C5)CC4)=O,Active,No,Jurkat,3.284020000000001,IC50: 130nM/45.1nM for CDK4/CDK6 respectively.,Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,13,2,,130 nM,Palbociclib,CC(C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O)=O,None,Other,0,0,0,703.7599999999999,No,,5L2I,LQQ,30802347,BSJ-04-060,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,179.79999999999995
+964,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C,Active,No,Jurkat,3.0553000000000026,"IC50: 175nM/142nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,175 nM,Ribociclib,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C,CCOCCOCCN,PEG,9,3,6,821.9399999999997,No,,5L2T,6ZZ,30802347,BSJ-01-151,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,196.45999999999998
+965,O=C(C1=CC2=CN=C(N([H])C3=NC=C(N4CCN(CCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C,Active,No,Jurkat,3.8023000000000025,"IC50: 79.7nM/65.5nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,13,3,,79.7 nM,Ribociclib,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C,CCCCN,Alkane,5,1,2,761.8879999999996,No,,5L2T,6ZZ,30802347,BSJ-01-152,No,,Reviewed,"P11802, Q00534",No,No,No,No,4,178.0
+966,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C,Active,No,Jurkat,2.9185000000000034,"IC50: 70.8nM/52.2nM for CDK4/CDK6, respectively; Show selective degradation of CDK4 (therefore active for CDK4 and inactive for CDK6).",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,14,4,,70.8 nM,Ribociclib,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C,CCCCNC(=O)CN,Other,9,3,4,818.9399999999997,"Yes, can also degrade IKZF1/3",,5L2T,6ZZ,30802347,BSJ-01-187,No,,Reviewed,P11802,No,No,No,No,4,207.09999999999997
+967,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCN4CCN(CC5=CC=C(NC6=NC=C(F)C(C7=CC(F)=C8C(N(C(C)C)C(C)=N8)=C7)=N6)N=C5)CC4)=O,Active,No,Jurkat,5.210520000000005,"IC50: 8.26nM/13.1nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,13,3,,8.26 nM,Abemaciclib,CCN(CC1)CCN1CC(C=C2)=CN=C2NC3=NC=C(C(C4=CC(F)=C(N=C5C)C(N5C(C)C)=C4)=N3)F,CCN,Alkane,3,1,0,805.8909999999998,"Yes, can also degrade CDK9",,5L2S,6ZV,30802347,BSJ-01-158,No,,Reviewed,Q00534,No,No,No,No,4,170.57999999999998
+968,O=C(NCCCCN1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C5C(N(C(C)C)C(C)=N5)=C4)=N3)N=C2)CC1)CNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,Jurkat,4.326720000000003,"IC50: 8.61nM/12.5nM for CDK4/CDK6, respectively.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,aliphatic_CC,14,4,,8.61 nM,Abemaciclib,CCN(CC1)CCN1CC(C=C2)=CN=C2NC3=NC=C(C(C4=CC(F)=C(N=C5C)C(N5C(C)C)=C4)=N3)F,CCNC(=O)CN,Alkane,7,3,2,862.9429999999996,"Yes, can also degrade CDK9",,5L2S,6ZV,30802347,BSJ-01-184,No,,Reviewed,Q00534,No,No,No,No,4,199.67999999999998
+969,O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,Yes,Jurkat; Molt4; Granta-519; Mino; Jeko; Rec1; Maver,3.054820000000001,"IC50: 26.9nM/10.4nM for CDK4/CDK6, respectively. Can degrade both CDK4 and CDK6.",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,15,3,,26.9 nM,Palbociclib,CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O,CCCCNC(=O)CO,Alkane,9,3,4,832.919,No,,5L2I,LQQ,30802347,BSJ-03-204,Yes,,Reviewed,Q00534,No,No,No,No,"4, 24, 72, 96",218.12999999999997
+970,O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,Yes,Mice primary Sertoli cells and primary Germ cells,3.0322000000000013,"This is an article that use a previously reported PROTAC (PMID: 33062164) as chemical biology tool to investigate the non-enzymatic FAK function in mice. Therefore, the relevant data were not given in this article.","Yangwode Jing, Ronen Gabizon",~ 1 nM,~ 100 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCOCCOCC)nn,PEG,12,5,7,949.93,No,,5TOB,YAM,32451721,FC-11,No,33062164,Reviewed,"Q05397, Q14289",No,No,No,No,8,273.96
+971,O=C(NCC1=CN(CCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.0883,,Yangwode Jing,,> 70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,18,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCn1ccnn1,PEG,10,4,4,920.8919999999999,No,,5TOB,7KD,33062164,FC-1,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,277.61999999999995
+972,O=C(NCC1=CN(CCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.104900000000002,,Yangwode Jing,,> 60 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,19,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCOCCn1ccnn1,PEG,13,5,7,964.9449999999998,No,,5TOB,7KD,33062164,FC-2,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,286.84999999999997
+973,O=C(NCC1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Inactive,No,PA1,2.121500000000005,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,20,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCOCCOCCn1ccnn1,PEG,16,6,10,1008.9979999999997,No,,5TOB,7KD,33062164,FC-3,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,296.08
+974,O=C(C1=CN(CCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.4106000000000005,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCn1cc(C(N)=O)nn1,PEG,13,6,5,906.865,No,,5TOB,7KD,33062164,FC-7,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,277.61999999999995
+975,O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.427200000000002,,Yangwode Jing,,> 95 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCOCCn1cc(C(N)=O)nn1,PEG,16,7,8,950.9179999999999,No,,5TOB,7KD,33062164,FC-8,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,286.84999999999997
+976,O=C(C1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=NC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.443800000000003,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,5,,,VS6063,CNC(C(C=C1)=CC=C1NC2=NC(NCC3=C(N(C)S(C)(=O)=O)N=CC=N3)=C(C(F)(F)F)C=N2)=O,CCOCCOCCOCCn1cc(C(N)=O)nn1,PEG,19,8,11,994.9709999999998,No,,5TOB,7KD,33062164,FC-9,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,296.0799999999999
+977,O=C(NCC1=CN(CCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.6933,,Yangwode Jing,,> 80 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,CCOCCn1ccnn1,PEG,10,4,4,919.904,No,,5TOB,YAM,33062164,FC-4,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,264.72999999999996
+978,O=C(NCC1=CN(CCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.709900000000001,,Yangwode Jing,,> 65 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,CCOCCOCCn1ccnn1,PEG,13,5,7,963.9569999999999,No,,5TOB,YAM,33062164,FC-5,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,273.96
+979,O=C(NCC1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Inactive,No,PA1,2.726500000000005,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,CCOCCOCCOCCn1ccnn1,PEG,16,6,10,1008.0099999999998,No,,5TOB,YAM,33062164,FC-6,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,283.19
+980,O=C(C1=CN(CCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,3.015600000000001,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCOCC)nn,PEG,9,4,4,905.8770000000001,No,,5TOB,YAM,33062164,FC-10,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,264.72999999999996
+981,O=C(C1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,3.0488000000000026,,Yangwode Jing,,> 94 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCOCCOCCOCC)nn,PEG,15,6,10,993.9829999999998,No,,5TOB,YAM,33062164,FC-12,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,283.18999999999994
+982,O=C(C1=CN(CCOCCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,3.065400000000005,,Yangwode Jing,,> 80 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,20,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCOCCOCCOCCOCC)nn,PEG,18,7,13,1038.0359999999998,No,,5TOB,YAM,33062164,FC-13,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,292.41999999999996
+983,O=C(C1=CN(CCCCCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,5.339600000000003,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,5,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCCCCCCC)nn,Alkane,12,3,7,945.986,No,,5TOB,YAM,33062164,FC-14,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,255.49999999999994
+984,O=C(C1=CN(CCOCCOCC#CC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,2.971800000000001,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,C#CCOCCOCCn(-c)nn,PEG,13,5,7,944.91,No,,5TOB,YAM,33062164,FC-15,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,261.92999999999995
+985,O=C(C1=CN(CCCCCOCC#CC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,4.1255000000000015,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,C#CCOCCCCCn(-c)nn,Other,13,4,7,942.938,No,,5TOB,YAM,33062164,FC-16,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,252.7
+986,O=C(C1=CN(CCCCCCCC#CC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,5.279200000000003,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,C#CCCCCCCCn(-c)nn,Alkane,13,3,7,940.9659999999999,No,,5TOB,YAM,33062164,FC-17,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,243.46999999999997
+987,O=C(C1=CN(CCOCCOCCCC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,3.552900000000003,,Yangwode Jing,,> 95 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCOCCOCCC)nn,PEG,13,5,8,948.942,No,,5TOB,YAM,33062164,FC-18,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,261.92999999999995
+988,O=C(C1=CN(CCCCCOCCCC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,4.706600000000002,,Yangwode Jing,,> 90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCCCCOCCC)nn,Other,13,4,8,946.9699999999999,No,,5TOB,YAM,33062164,FC-19,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,252.7
+989,O=C(C1=CN(CCCCCCCCCC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=N6)C=C5,Active,No,PA1,5.860300000000004,,Yangwode Jing,,> 85 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,4,,,PF562271,CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O,cn(CCCCCCCCC)nn,Alkane,13,3,8,944.9979999999999,No,,5TOB,YAM,33062164,FC-20,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,243.46999999999997
+990,O=C(C1=CN(CCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=NC=C6C(F)(F)F)C=C5,Inactive,No,PA1,3.015600000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,5,,,PF562271 analogue,O=S(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC(CC(N4)=O)=C4C=C3)=C(C(F)(F)F)C=N2)(C)=O,cn(CCOCC)nn,PEG,9,4,4,905.8770000000001,No,,5TOB,YAM,33062164,FC-21,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,264.72999999999996
+991,O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=NC=C6C(F)(F)F)C=C5,Inactive,No,PA1,3.0322000000000013,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,5,,,PF562271 analogue,O=S(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC(CC(N4)=O)=C4C=C3)=C(C(F)(F)F)C=N2)(C)=O,cn(CCOCCOCC)nn,PEG,12,5,7,949.93,No,,5TOB,YAM,33062164,FC-22,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,273.96
+992,O=C(C1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC(NCC7=CC=CN=C7N(C)S(=O)(C)=O)=NC=C6C(F)(F)F)C=C5,Inactive,No,PA1,3.0488000000000044,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,5,,,PF562271 analogue,O=S(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC(CC(N4)=O)=C4C=C3)=C(C(F)(F)F)C=N2)(C)=O,cn(CCOCCOCCOCC)nn,PEG,15,6,10,993.9829999999998,No,,5TOB,YAM,33062164,FC-23,No,,Reviewed,"Q05397, Q14289",No,No,No,No,8,283.18999999999994
+993,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCN(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)CC5)N=C4)C=C2)C3=O)C9=CC=CC=C9,Active,Yes,Ba/F3; H1975,4.2260000000000035,EC50: 0.096uM for L858R/T790M mutant EGFR Ba/F3 cells; >10uM for wildtype EGFR Ba/F3 cells,Yangwode Jing,,> 70 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,4.9 uM,0.096 uM,amine_to_methylamine,15,3,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCCOCC,PEG,11,3,8,942.0680000000001,No,,,,32510788,DDC-01-163,No,,Reviewed,P00533,Yes,Yes,No,No,"0, 4, 6, 8, 24, 48, 72",204.94
+994,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCN(CCOCCOCCOCCOC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)CC5)N=C4)C=C2)C3=O)C9=CC=CC=C9,Active,No,Ba/F3,4.192900000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,4.9 uM,2.07 uM,amine_to_methylamine,15,2,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCCOCCO,PEG,12,4,9,943.0520000000001,No,,,,32510788,11o,No,,Reviewed,P00533,No,No,No,No,72,202.14
+995,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCN(CCOCCOCCOCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)CC5)N=C4)C=C2)C3=O)C9=CC=CC=C9,Inactive,No,Ba/F3,4.226000000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,4.9 uM,,amine_to_methylamine,15,3,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCCOCC,PEG,11,3,8,942.0680000000001,No,,,,32510788,11n,No,,Reviewed,P00533,No,No,No,No,72,204.94
+996,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCN(CCOCCOCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)CC5)N=C4)C=C2)C3=O)C9=CC=CC=C9,Inactive,No,Ba/F3,4.209400000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,4.9 uM,,amine_to_methylamine,14,3,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCC,PEG,8,2,5,898.0150000000001,No,,,,32510788,11m,No,,Reviewed,P00533,No,No,No,No,72,195.70999999999998
+997,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCN(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)CC5)C=C4)C=C2)C3=O)C9=CC(F)=CC=C9O,Active,No,Ba/F3,4.675700000000004,Targeting EGFR L858R/T790M mutant,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,0.477 uM,amine_to_methylamine,15,4,,19 nM,JBJ-04-125-02,O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N(CC3=C4C=C(C5=CC=C(N6CCNCC6)C=C5)C=C3)C4=O,CCOCCOCCOCC,PEG,11,3,8,975.0690000000002,No,,,,32510788,JBJ-07-038,No,,Reviewed,P00533,Yes,No,No,No,"6, 24, 48, 72",212.27999999999997
+998,O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2F)N(CC3=C4C=C(C5=CC=C(N6CCN(CCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)CC6)C=C5)C=C3)C4=O,Active,No,Ba/F3,5.109200000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,0.153 uM,amine_to_methylamine,14,3,,390 nM,JBJ-04-125-02 analogue,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CC=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC(F)=CC=C6F,CCOCCOCCOCC,PEG,11,3,8,977.0599999999997,No,,,,32510788,JBJ-07-200,No,,Reviewed,P00533,Yes,No,No,No,"6, 24, 48, 72",192.04999999999998
+999,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CC(NCCOCCOCCOCCNC(COC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,3.0303000000000084,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_methylamine,16,4,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CC(=O)NCCOCCOCCOCCNC(=O)CO,PEG,20,8,13,1056.1679999999994,No,,,,32510788,11a,No,,Reviewed,P00533,No,No,No,No,72,247.45
+1000,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CC(NCCCCNC(COC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,3.7607000000000026,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_methylamine,13,4,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CC(=O)NCCCCNC(=O)CO,Other,13,5,6,952.0629999999999,No,,,,32510788,11b,No,,Reviewed,P00533,No,No,No,No,72,219.76
+1001,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CCCCCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,6.341600000000006,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_methylamine,11,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCCCCC,Alkane,6,0,3,865.0289999999999,No,,,,32510788,11c,No,,Reviewed,P00533,No,No,No,No,72,164.36
+1002,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CCCCCCCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,7.1218000000000075,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_methylamine,11,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCCCCCCC,Alkane,8,0,5,893.083,No,,,,32510788,11d,No,,Reviewed,P00533,No,No,No,No,72,164.36
+1003,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(C(CCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,4.714500000000003,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_amide,12,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCC=O,Other,7,2,4,880.9839999999999,No,,,,32510788,11e,No,,Reviewed,P00533,No,No,No,No,72,190.65999999999997
+1004,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(C(CCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,4.731100000000003,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_amide,13,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCCC=O,PEG,10,3,7,925.0369999999999,No,,,,32510788,11f,No,,Reviewed,P00533,No,No,No,No,72,199.89
+1005,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(C(CCOCCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)CC5)NC9=NC=CS9,Active,No,Ba/F3,4.747700000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,0.126 uM,amine_to_amide,14,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCCOCCC=O,PEG,13,4,10,969.0899999999998,No,,,,32510788,11g,No,,Reviewed,P00533,No,No,No,No,72,209.12
+1006,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(C(CCOCCOCCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,4.764300000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_amide,15,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCCOCCOCCC=O,PEG,16,5,13,1013.1429999999997,No,,,,32510788,11h,No,,Reviewed,P00533,No,No,No,No,72,218.34999999999997
+1007,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(C(CCOCCOCCOCCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,4.780900000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_amide,16,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCCOCCOCCOCCC=O,PEG,19,6,16,1057.1959999999997,No,,,,32510788,11i,No,,Reviewed,P00533,No,No,No,No,72,227.57999999999998
+1008,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,4.814400000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,amine_to_methylamine,13,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCC,PEG,8,2,5,897.0269999999999,No,,,,32510788,11j,No,,Reviewed,P00533,No,No,No,No,72,182.82
+1009,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCN(CCOCCOCCOCCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)CC5)NC9=NC=CS9,Active,No,Ba/F3,4.831000000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,0.161 uM,amine_to_methylamine,14,3,,,JBJ-07-149 analogue,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CC=C(C=C4)N5CCNCC5)NC6=NC=CS6,CCOCCOCCOCC,PEG,11,3,8,941.0799999999997,No,,,,32510788,11k,No,,Reviewed,P00533,No,No,No,No,72,192.05
+1010,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CN=C(C=C4)N5CCN(CCOCCOCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H](C6)O)[C@@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,6.888220000000008,,Yangwode Jing,,,O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)N)=O)N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C,VHL,4.9 uM,> 10 uM,amine_to_methylamine,15,4,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCCC=O,PEG,10,3,7,1097.378,No,,,,32510788,11p,No,,Reviewed,P00533,No,No,No,No,72,211.76
+1011,O=C(C(C1=CC=CC=C1)N(C2=O)CC3=C2C=C(C=C3)C4=CN=C(C=C4)N5CCN(CCOCCOCCOCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H](C6)O)[C@@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)=O)CC5)NC9=NC=CS9,Inactive,No,Ba/F3,6.904820000000008,,Yangwode Jing,,,O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)N)=O)N[C@@H](C)C2=CC=C(C=C2)C3=C(N=CS3)C,VHL,4.9 uM,> 10 uM,amine_to_methylamine,16,4,1.1 nM,,JBJ-07-149,O=C(NC1=NC=CS1)C(N(CC2=C3C=C(C4=CN=C(N5CCNCC5)C=C4)C=C2)C3=O)C6=CC=CC=C6,CCOCCOCCOCCC=O,PEG,13,4,10,1141.431,No,,,,32510788,11q,No,,Reviewed,P00533,No,No,No,No,72,220.99
+1012,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(CCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C,Active,No,Jurkat,2.8854000000000024,"IC50: 50.6nM/30nM for CDK4/CDK6, respectively; Show selective degradation of CDK4 (therefore active for CDK4 and inactive for CDK6).",Yangwode Jing,,,O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1,Cereblon,,,amine_to_methylamine,14,3,,50.6 nM,Ribociclib,O=C(C1=CC2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5)N(C)C,CCCCNC(=O)CO,Other,9,3,4,819.9239999999998,No,,5L2T,6ZZ,30802347,BSJ-04-132,Yes,,Reviewed,P11802,No,No,No,No,4,204.3
+1013,O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)/C(CCC1(C)C)=N/OCC(NCCOCCOCCOC([C@@H](NC([C@@H](O)[C@H](N)CC2=CC=CC=C2)=O)CC(C)C)=O)=O,Active,No,"HT1080, IMR-32, MCF-7",4.739500000000006,,"Yangwode Jing, Ronen Gabizon",~ 100 nM,> 90 %,N[C@@H]([C@@H](C(N[C@H](C(OC)=O)CC(C)C)=O)O)CC1=CC=CC=C1,cIAP1,,,other,11,5,,,ATRA,CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(O)=O,COCCOCCNC(=O)CON,PEG,13,6,8,809.0140000000002,"Yes, can degrade both CRABP2 and cIAP1",,3CBS,R12,21515062,Ester-type SNIPER,No,,Reviewed,P29373,No,No,No,No,"0.25, 0.5, 1, 2, 6, 24, 48, 72",208.1
+1014,O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)/C(CCC1(C)C)=N/OCC(NCCOCCOCCNC([C@@H](NC([C@@H](O)[C@H](N)CC2=CC=CC=C2)=O)CC(C)C)=O)=O,Active,Yes,"HT1080, IMR-32, MCF-7",4.312500000000007,,"Yangwode Jing, Ronen Gabizon",~ 100 nM,> 90 %,N[C@@H]([C@@H](C(N[C@H](C(NC)=O)CC(C)C)=O)O)CC1=CC=CC=C1,cIAP1,,,other,10,6,,,ATRA,CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(O)=O,COCCOCCNC(=O)CON,PEG,13,6,8,808.0300000000002,No,,3CBS,R12,21515062,Amide-type SNIPER,No,,Reviewed,P29373,No,Yes,No,Yes,"0.25, 0.5, 1, 2, 6, 24, 48, 72",210.9
+1015,O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)/C(CCC1(C)C)=N/OCC(NCCOCCOCCNC([C@@H](NC(CCCC2=CC=CC=C2)=O)CC(C)C)=O)=O,Inactive,No,HT1080,6.404500000000007,,Yangwode Jing,,,O=C(CCCC1=CC=CC=C1)N[C@H](C(NC)=O)CC(C)C,cIAP1,,,other,8,4,,,ATRA,CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(O)=O,COCCOCCNC(=O)CON,PEG,13,6,8,777.0160000000001,No,,3CBS,R12,21515062,Compound 8,No,,Reviewed,P29373,No,No,No,No,6,164.65
+1016,O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1OCCCNC(COCCOCCOCCNC([C@@H](NC([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)CC(C)C)=O)=O,Active,Yes,HT1080,5.388800000000007,The PDB ligand ID is for Am80,"Yangwode Jing, Ronen Gabizon",~ 10 uM,~ 90 %,N[C@@H]([C@@H](C(N[C@H](C(NC)=O)CC(C)C)=O)O)CC1=CC=CC=C1,cIAP1,,,aryl_O,11,6,,,Ch55,CC(C)(C1=CC(C(/C=C/C(C=C2)=CC=C2C(O)=O)=O)=CC(C(C)(C)C)=C1)C,COCCOCCOCC(=O)NCCCO,PEG,16,6,11,917.1539999999999,No,,3KMR,EQN,22014751,9,No,,Reviewed,P10276,Yes,Yes,No,Yes,"6, 24",224.84
+1017,CC(C)C[C@H](NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O)C(NCCOCCOCCNC(CO/N=C2CC[C@@]3([H])[C@]4([H])CCC5=CC(O)=CC=C5[C@@]4([H])CC[C@]\23C)=O)=O,Active,No,MCF-7,3.3483000000000063,,Yangwode Jing,,,N[C@@H]([C@@H](C(N[C@H](C(NC)=O)CC(C)C)=O)O)CC1=CC=CC=C1,cIAP1,,,other,10,6,,,Estrone,OC(C=C1)=CC(CC[C@@]2([H])[C@]3([H])CC4)=C1[C@@]2([H])CC[C@]3(C)C4=O,COCCOCCNC(=O)CON,PEG,13,6,8,763.9770000000001,No,,,,22014751,11,No,,Reviewed,P03372,Yes,No,No,No,24,193.82999999999998
+1018,O=C(O[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC5=CC=CC=C5)=O)=O,Active,No,MCF-7,4.1378000000000075,,Yangwode Jing,,,N[C@@H]([C@@H](C(N[C@H](C(NC)=O)CC(C)C)=O)O)CC1=CC=CC=C1,cIAP1,,,other,10,4,,,DHT,O[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O,COCCOCCOCC=O,PEG,11,4,8,770.0210000000003,No,,1T5Z,DHT,22014751,13,No,,Reviewed,P10275,No,No,No,No,24,175.51000000000002
+1019,CN(C(CCNC(CCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC1=CC=CC=C1)N)=O)=O)=O)=O)CCOC(C=C2)=CC=C2/C(C(C=C3)=CC=C3O)=C(CC)\C4=CC=CC=C4,Active,No,MCF-7,5.072900000000009,,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,"['amine_to_amide', 'aliphatic_CC']",8,6,,,Endoxifen,OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1,CCNC(=O)CCN,Alkane,8,3,3,806.0170000000002,No,,3ERT,OHT,22277276,5,No,,Reviewed,P03372,No,No,No,Yes,6,183.31999999999996
+1020,CN(C(CCCCNC(CCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC1=CC=CC=C1)N)=O)=O)=O)=O)CCOC(C=C2)=CC=C2/C(C(C=C3)=CC=C3O)=C(CC)\C4=CC=CC=C4,Active,No,MCF-7,5.853100000000011,,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,"['amine_to_amide', 'aliphatic_CC']",8,6,,,Endoxifen,OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1,CCCCNC(=O)CCN,Alkane,10,3,5,834.071,No,,3ERT,OHT,22277276,6,No,,Reviewed,P03372,No,No,No,Yes,6,183.31999999999996
+1021,CN(C(CCCCCCNC(CCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC1=CC=CC=C1)N)=O)=O)=O)=O)CCOC(C=C2)=CC=C2/C(C(C=C3)=CC=C3O)=C(CC)\C4=CC=CC=C4,Active,No,MCF-7,6.633300000000012,,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,"['amine_to_amide', 'aliphatic_CC']",8,6,,,Endoxifen,OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)\CC)C=C1,CCCCCCNC(=O)CCN,Alkane,12,3,7,862.1249999999999,No,,3ERT,OHT,22277276,7,No,,Reviewed,P03372,No,No,No,Yes,6,183.31999999999996
+1022,O=C([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC)C)=O)C2CCCCC2)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)NCCOCCOCCNC(CO/N=C5CCC(C)(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C\5C)=O,Active,Yes,"HT1080, IMR-32",6.831600000000013,,"Yangwode Jing, Ronen Gabizon",~ 1 uM,,O=C([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC)C)=O)C2CCCCC2)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)OC,cIAP1,,,other,11,6,,,ATRA,CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C\C(O)=O,NCCOCCOCCNC(=O)CON,PEG,15,7,10,1062.3629999999994,No,,3CBS,R12,22658364,6,No,,Reviewed,"P29373, Q13490",No,No,No,Yes,"6, 24, 48, 72",226.08999999999995
+1023,CC(C[C@H](C(NCCCCCCC(NCC1=CC=C(C(NC2=CC(NC3=NC=CC(C4=CN=CC=C4)=N3)=C(C=C2)C)=O)C=C1)=O)=O)NC([C@@H]([C@H](Cc5ccccc5)N)O)=O)C,Inactive,No,K562,5.987620000000005,BCR-ABL degredation,Yangwode Jing,,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,other,10,7,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCN,Alkane,6,1,3,828.0310000000002,No,,2HYY,STI,27666635,SNIPER(ABL)-1,No,,Reviewed,P00519,No,No,No,No,"8, 24",213.35
+1024,CC(C[C@H](C(NCCCCCCCC(NCC1=CC=C(C(NC2=CC(NC3=NC=CC(C4=CN=CC=C4)=N3)=C(C=C2)C)=O)C=C1)=O)=O)NC([C@@H]([C@H](Cc5ccccc5)N)O)=O)C,Active,Yes,K562,6.377720000000005,BCR-ABL degredation,"Yangwode Jing, Ronen Gabizon",~ 30 uM,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,other,10,7,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCCN,Alkane,7,1,4,842.0580000000001,No,,2HYY,STI,27666635,SNIPER(ABL)-2,No,,Reviewed,P00519,No,No,No,No,"8, 24",213.35
+1025,CC(C[C@H](C(NCCCCCCCCC(NCC1=CC=C(C(NC2=CC(NC3=NC=CC(C4=CN=CC=C4)=N3)=C(C=C2)C)=O)C=C1)=O)=O)NC([C@@H]([C@H](Cc5ccccc5)N)O)=O)C,Active,No,K562,6.767820000000007,BCR-ABL degredation,"Yangwode Jing, Ronen Gabizon",~ 30 uM,,CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O,Iap,,,other,10,7,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCCCCCN,Alkane,8,1,5,856.085,No,,2HYY,STI,27666635,SNIPER(ABL)-3,No,,Reviewed,P00519,No,No,No,No,"8, 24",213.35
+1027,O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5,Active,Yes,"BxPC3, DLD-1, HCT-116, MDA-MB-231, A549, PC-9",3.3035000000000014,"Above EC50 was obtained in BxPC3 cells. EC50 for DLD-1/HCT-116/MDA-MB-231/A549/PC-9 cells: 4.09uM/6.47uM/>10uM/2.42uM/>10uM, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,1.216 uM,0.165 uM,aryl_C,14,5,2.5 nM,2.7 nM,ABBV-075,CCS(=O)(NC1=CC=C(C(C2=CN(C(C3=C2C=CN3)=O)C)=C1)OC4=CC=C(C=C4F)F)=O,O=CCOCCn1cc(CNC=O)nn1,PEG,15,7,8,926.9159999999994,No,,5UVX,,32361153,32a,No,,Reviewed,O60885,No,No,No,No,"1, 2, 3, 4, 8, 24, 48",257.80999999999995
+1028,O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5,Active,No,"BxPC3, DLD-1, HCT-116, MDA-MB-231, A549, PC-9",3.320100000000002,"Above EC50 was obtained in BxPC3 cells. EC50 for DLD-1/HCT-116/MDA-MB-231/A549/PC-9 cells: 5.96uM/2.22uM/>10uM/0.39uM/>10uM, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,1.216 uM,0.245 uM,aryl_C,15,5,2.5 nM,3.4 nM,ABBV-075,CCS(=O)(NC1=CC=C(C(C2=CN(C(C3=C2C=CN3)=O)C)=C1)OC4=CC=C(C=C4F)F)=O,O=CCOCCOCCn1cc(CNC=O)nn1,PEG,18,8,11,970.9689999999993,No,,5UVX,,32361153,32b,No,,Reviewed,O60885,No,No,No,No,"24, 48",267.03999999999996
+1029,O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCCOCCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5,Active,No,"BxPC3, DLD-1, HCT-116, MDA-MB-231, A549, PC-9",3.3367000000000013,"Above EC50 was obtained in BxPC3 cells. EC50 for DLD-1/HCT-116/MDA-MB-231/A549/PC-9 cells: 2.04uM/4.39uM/>10uM/0.30uM/>10uM, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,1.216 uM,4.138 uM,aryl_C,16,5,2.5 nM,3.7 nM,ABBV-075,CCS(=O)(NC1=CC=C(C(C2=CN(C(C3=C2C=CN3)=O)C)=C1)OC4=CC=C(C=C4F)F)=O,O=CCOCCOCCOCCn1cc(CNC=O)nn1,PEG,21,9,14,1015.0219999999991,No,,5UVX,,32361153,32c,No,,Reviewed,O60885,No,No,No,No,24,276.2699999999999
+1030,O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCCOCCOCCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5,Inactive,No,"BxPC3, DLD-1, HCT-116, MDA-MB-231, A549, PC-9",3.3533000000000017,"Above EC50 was obtained in BxPC3 cells. EC50 for DLD-1/HCT-116/MDA-MB-231/A549/PC-9 cells: >10uM/>10uM/>10uM/2.14uM/>10uM, respectively.",Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,1.216 uM,> 10 uM,aryl_C,17,5,2.5 nM,12.0 nM,ABBV-075,CCS(=O)(NC1=CC=C(C(C2=CN(C(C3=C2C=CN3)=O)C)=C1)OC4=CC=C(C=C4F)F)=O,O=CCOCCOCCOCCOCCn1cc(CNC=O)nn1,PEG,24,10,17,1059.0749999999991,No,,5UVX,,32361153,32d,No,,Reviewed,O60885,No,No,No,No,24,285.49999999999994
+1031,O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=CC=NC5=CC(OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)=C(OC)C=C45)C(F)=C3,Active,Yes,MDA-MB-231,8.494620000000006,,Yangwode Jing,210 nM,91 %,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,14,5,,,foretinib,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1O,CCCOCCCOCCC=O,PEG,12,3,9,1106.2589999999996,Yes. This PROTAC can also degrade other 35 kinases including c-Met,,,,29129718,1,Yes,,Reviewed,Q16539,Yes,No,No,Yes,24,228.86999999999995
+1032,O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=CC=NC5=CC(OCCCOCCCOCCC(NCCOC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)=C(OC)C=C45)C(F)=C3,Active,Yes,MDA-MB-231,5.850000000000005,,Yangwode Jing,27 nM,91 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,4,,,foretinib,COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1O,CCCOCCCOCCC(=O)NCCO,PEG,16,5,11,992.9859999999998,Yes. This PROTAC can also degrade other 61 proteins including c-Met,,,,29129718,2,Yes,,Reviewed,O15264,Yes,No,No,Yes,24,239.11999999999998
+1033,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCCCN4CCN(C5=NC(N6C(C(F)F)=NC7=CC=CC=C67)=NC(N8CCOCC8)=N5)CC4,Inactive,No,,2.7070000000000007,Compound A was not subjected to any cell experiment,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,14,2,16 nM,2847 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NCCCCCC=O,Alkane,8,2,5,785.8129999999998,No,,2WXL,ZS4,29625382,A,No,,Reviewed,P42336,No,No,No,No,,188.08999999999997
+1034,O=C(NCCCC(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)CCC(N4CCN(C5=NC(N6C(C(F)F)=NC7=CC=CC=C67)=NC(N8CCOCC8)=N5)CC4)=O,Active,No,HepG2,1.3498000000000014,,"Yangwode Jing, Ronen Gabizon",> 10 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,15,3,16 nM,18 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NC(=O)CCC(=O)NCCCC=O,Other,13,5,7,856.8479999999997,No,,2WXL,ZS4,29625382,B,No,,Reviewed,P42336,No,No,No,No,"6, 12, 24",234.26
+1035,O=C(NCCCCCC(N1CCN(C2=NC(N3C(C(F)F)=NC4=CC=CC=C34)=NC(N5CCOCC5)=N2)CC1)=O)CCC(NCCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)=O,Inactive,No,HepG2,2.026400000000006,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,16,4,16 nM,38 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NC(=O)CCCCCNC(=O)CCC(=O)NCCCC=O,Other,21,7,13,970.0079999999994,No,,2WXL,ZS4,29625382,C,No,,Reviewed,P42336,No,No,No,No,6,263.36
+1036,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCCCNC(CCC(N4CCN(C5=NC(N6C(C(F)F)=NC7=CC=CC=C67)=NC(N8CCOCC8)=N5)CC4)=O)=O,Active,Yes,HepG2,2.130000000000001,,"Yangwode Jing, Ronen Gabizon",> 10 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,15,3,16 nM,24 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NC(=O)CCC(=O)NCCCCCC=O,Other,15,5,9,884.9019999999998,No,,2WXL,ZS4,29625382,D,No,,Reviewed,P42336,No,No,No,No,"6, 12, 24",234.26
+1037,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=NC(CN5CCN(C6=NC(N7C(C(F)F)=NC8=CC=CC=C78)=NC(N9CCOCC9)=N6)CC5)=C4,Active,No,HepG2,1.7185000000000001,,"Yangwode Jing, Ronen Gabizon",> 10 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,17,2,16 nM,90 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NCc1cn(CCCC=O)nn1,Other,12,5,5,838.8369999999998,No,,2WXL,ZS4,29625382,E,No,,Reviewed,P42336,No,No,No,No,"6, 12, 24",218.8
+1038,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCCCN4N=NC(CN5CCN(C6=NC(N7C(C(F)F)=NC8=CC=CC=C78)=NC(N9CCOCC9)=N6)CC5)=C4,Active,No,HepG2,2.4987000000000004,,"Yangwode Jing, Ronen Gabizon",> 10 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,morpholine_to_piperazine,17,2,16 nM,86 nM,ZSTK474,FC(C1=NC2=CC=CC=C2N1C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)F,NCc1cn(CCCCCC=O)nn1,Other,14,5,7,866.8909999999997,No,,2WXL,ZS4,29625382,F,No,,Reviewed,P42336,No,No,No,No,"6, 12, 24",218.8
+1041,O=P([O-])(NCCCCCC(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)=O)OC[C@@H]4O[C@H](N5C=NC6=C5N=C(N)NC6=O)[C@@H](O)[C@H]4O,Inactive,No,MDA-MB-231; K562,-1.6442999999999948,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,7,,,GMP,O=P([O-])OC[C@@H]1O[C@H](N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@H]1O,NCCCCCC=O,Alkane,8,2,5,716.6250000000002,No,,1EJ1,M7G,30735900,4,No,,Reviewed,P06730,No,No,No,No,"24, 72",296.25
+1042,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=CC=C4)=C2)COP(O)(NCCCCCC(N[C@H](CCC=C56)C6CN([C@@H](CC7)C(NC7=O)=O)C5=O)=O)=O,Inactive,No,MDA-MB-231; K562,-1.0025999999999893,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,8,,,Bn7GMP,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=CC=C4)=C2)COP(O)=O,NCCCCCC=O,Alkane,8,2,5,812.7979999999999,No,,1EJ1,M7G,30735900,5a,No,,Reviewed,P06730,No,No,No,No,"24, 72",284.40999999999997
+1043,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=C(F)C=C4)=C2)COP(O)(NCCCCCC(N[C@H](CCC=C56)C6CN([C@@H](CC7)C(NC7=O)=O)C5=O)=O)=O,Inactive,No,MDA-MB-231; K562,-0.8634999999999904,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,13,8,,,4F-Bn7GMP,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=C(F)C=C4)=C2)COP(O)=O,NCCCCCC=O,Alkane,8,2,5,830.7879999999998,No,,1EJ1,M7G,30735900,5b,No,,Reviewed,P06730,No,No,No,No,"24, 72",284.40999999999997
+1044,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@@H]4O[C@H](COS(=O)(NC(CCC(NCCCCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)=O)=O)=O)[C@@H](O)[C@H]4O,Inactive,No,MDA-MB-231; K562,-1.3649999999999913,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,8,,,Sulfamate-containing 4F-Bn7GMP,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=C(F)C=C4)=C2)COS(=O)(O)=O,NC(=O)CCC(=O)NCCCCCC=O,Other,15,5,9,925.9300000000001,No,,1EJ1,M7G,30735900,13b,No,,Reviewed,P06730,No,No,No,No,"24, 72",327.42
+1045,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@@H]4O[C@H](COS(=O)(NC(CCC(NCCCCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)=O)=O)=O)[C@@H](O)[C@H]4O,Inactive,No,MDA-MB-231; K562,-1.504099999999991,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,8,,,Sulfamate-containing Bn7GMP,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)[N+](CC4=CC=CC=C4)=C2)COS(=O)(O)=O,NC(=O)CCC(=O)NCCCCCC=O,Other,15,5,9,907.9400000000003,No,,1EJ1,M7G,30735900,13a,No,,Reviewed,P06730,No,No,No,No,"24, 72",327.42
+1046,O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COS(=O)(NC(CCC(NCCCCCC(NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)=O)=O)=O)[C@@H](O)[C@H]3O,Inactive,No,MDA-MB-231; K562,-2.444899999999991,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,17,8,,,Sulfamate-containing GMP,O[C@H]1[C@@H](O[C@@H]([C@H]1O)N2C3=C(C(NC(N)=N3)=O)N=C2)COS(=O)(O)=O,NC(=O)CCC(=O)NCCCCCC=O,Other,15,5,9,816.8070000000004,No,,1EJ1,M7G,30735900,12,No,,Reviewed,P06730,No,No,No,No,"24, 72",336.43
+1047,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCCCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,0.18460000000000198,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,9,,,4F-Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCCCCC=O,Alkane,8,2,5,906.7350000000004,No,,1EJ1,M7G,30735900,23b,No,,Reviewed,P06730,No,No,No,No,"24, 72",330.94
+1048,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCCCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,0.04550000000000204,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,9,,,Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCCCCC=O,Alkane,8,2,5,888.7450000000003,No,,1EJ1,M7G,30735900,23a,No,,Reviewed,P06730,No,No,No,No,"24, 72",330.94
+1049,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(NCCCCCC(NC4=CC=CC5=C4CN(C(CC6)C(NC6=O)=O)C5=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,Inactive,No,MDA-MB-231; K562,-0.8952999999999975,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,9,,,GDP,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,NCCCCCC=O,Alkane,8,2,5,797.6120000000005,,,1EJ1,M7G,30735900,20,No,,Reviewed,P06730,No,No,No,No,"24, 72",339.95000000000005
+1050,O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)CCOCCOCCOCCNP(OP(OC[C@@H]4O[C@H](N5C=NC6=C5N=C(N)NC6=O)[C@@H](O)[C@H]4O)(O)=O)(O)=O,Inactive,No,MDA-MB-231; K562,-2.0157999999999943,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,19,9,,,GDP,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,NCCOCCOCCOCCC=O,PEG,14,5,11,887.6900000000004,No,,1EJ1,M7G,30735900,21,No,,Reviewed,P06730,No,No,No,No,"24, 72",367.64000000000004
+1051,O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)CCOCCOCCOCCOCCOCCOCCOCCNP(OP(OC[C@@H]4O[C@H](N5C=NC6=C5N=C(N)NC6=O)[C@@H](O)[C@H]4O)(O)=O)(O)=O,Inactive,No,MDA-MB-231; K562,-1.94939999999999,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,23,9,,,GDP,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,NCCOCCOCCOCCOCCOCCOCCOCCC=O,PEG,26,9,23,1063.9020000000003,No,,1EJ1,M7G,30735900,22,No,,Reviewed,P06730,No,No,No,No,"24, 72",404.56
+1052,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCOCCOCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,-1.074999999999994,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,9,,,Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCOCCOCCOCCC=O,PEG,14,5,11,978.8230000000001,No,,1EJ1,M7G,30735900,24a,No,,Reviewed,P06730,No,No,No,No,"24, 72",358.63
+1053,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@@H]4O[C@H](COP(OP(NCCOCCOCCOCCOCCOCCOCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]4O,Inactive,No,MDA-MB-231; K562,-1.0085999999999882,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,22,9,,,Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCOCCOCCOCCOCCOCCOCCOCCC=O,PEG,26,9,23,1155.0349999999996,No,,1EJ1,M7G,30735900,25a,No,,Reviewed,P06730,No,No,No,No,"24, 72",395.55
+1054,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCOCCOCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,-0.9358999999999942,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,9,,,4F-Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCOCCOCCOCCC=O,PEG,14,5,11,996.813,No,,1EJ1,M7G,30735900,24b,No,,Reviewed,P06730,No,No,No,No,"24, 72",358.63
+1055,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@@H]4O[C@H](COP(OP(NCCOCCOCCOCCOCCOCCOCCOCCC(NC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]4O,Inactive,No,MDA-MB-231; K562,-0.8694999999999893,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,22,9,,,4F-Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCOCCOCCOCCOCCOCCOCCOCCC=O,PEG,26,9,23,1173.0249999999994,No,,1EJ1,M7G,30735900,25b,No,,Reviewed,P06730,No,No,No,No,"24, 72",395.55
+1056,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCCCCC(N[C@@H](C(C)(C)C)C(N5C(C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@H](O)C5)=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,2.0259200000000033,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,10,,,4F-Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=C(F)C=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCCCCC=O,Alkane,8,2,5,1078.0440000000003,No,,1EJ1,M7G,30735900,30b,No,,Reviewed,P06730,No,No,No,No,"24, 72",346.99
+1057,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(NCCCCCC(N[C@@H](C(C)(C)C)C(N5C(C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@H](O)C5)=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,Inactive,No,MDA-MB-231; K562,1.8868200000000033,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,17,10,,,Bn7GDP,O=C1NC(N)=NC2=C1[N+](CC3=CC=CC=C3)=CN2[C@H]4O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]4O,NCCCCCC=O,Alkane,8,2,5,1060.054,No,,1EJ1,M7G,30735900,30a,No,,Reviewed,P06730,No,No,No,No,"24, 72",346.99
+1058,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(NCCCCCC(N[C@@H](C(C)(C)C)C(N4C(C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@H](O)C4)=O)=O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,Inactive,No,MDA-MB-231; K562,0.9460200000000021,,Yangwode Jing,,,Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1,VHL,,,other,18,10,,,GDP,O=C1NC(N)=NC2=C1N=CN2[C@H]3O[C@@H](COP(OP(O)(O)=O)(O)=O)[C@H](O)[C@@H]3O,NCCCCCC=O,Alkane,8,2,5,968.9210000000004,No,,1EJ1,M7G,30735900,29,No,,Reviewed,P06730,No,No,No,No,"24, 72",356.0
+1059,O=C(C(N(CC1=C2C=CC=C1C#CCN3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Active,Yes,RS4;11,7.784700000000009,,"Yangwode Jing, Ronen Gabizon",~ 100 nM,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,7.2 nM,amine_to_methylamine,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CC,Other,3,0,0,859.8549999999994,No,,4IPF,1F0,31128449,20,No,,Reviewed,Q00987,No,No,No,No,6,114.85999999999999
+1060,O=C(C(N(CC1=C2C=CC=C1C#CCCN3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.17480000000001,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCC,Other,4,0,0,873.8819999999994,No,,4IPF,1F0,31128449,21,No,,Reviewed,Q00987,No,No,No,No,6,114.85999999999999
+1061,O=C(C(N(CC1=C2C=CC=C1C#CCCCN3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.564900000000009,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCC,Other,5,0,1,887.9089999999994,No,,4IPF,1F0,31128449,22,No,,Reviewed,Q00987,No,No,No,No,6,114.85999999999999
+1062,O=C(NCC(N1CCN(C(N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1)=O)CCC#CC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O,Inactive,No,RS4;11,7.20770000000001,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,8,2,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCC(=O)NCC=O,Other,10,3,4,958.9439999999994,No,,4IPF,1F0,31128449,14,No,,Reviewed,Q00987,No,No,No,No,6,161.03
+1063,O=C(NCC(N1CCN(C(N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1)=O)CCCC#CC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O,Active,No,RS4;11,7.597800000000011,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,8,2,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCCC(=O)NCC=O,Other,11,3,5,972.9709999999993,No,,4IPF,1F0,31128449,15,No,,Reviewed,Q00987,No,No,No,No,6,161.03
+1064,O=C(NCC(N1CCN(C(N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1)=O)CCCCC#CC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O,Inactive,No,RS4;11,7.987900000000011,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,8,2,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCCCC(=O)NCC=O,Other,12,3,6,986.9979999999993,No,,4IPF,1F0,31128449,16,No,,Reviewed,Q00987,No,No,No,No,6,161.03
+1065,O=C(C(N(CC1=C2C=CC=C1C#CCCC(N3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)=O)C2=O)CC8)NC8=O,Active,No,RS4;11,8.09150000000001,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCC=O,Other,6,1,2,901.8919999999995,No,,4IPF,1F0,31128449,7,No,,Reviewed,Q00987,No,No,No,No,6,131.92999999999998
+1066,O=C(C(N(CC1=C2C=CC=C1C#CCCCC(N3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)=O)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.481600000000007,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCCC=O,Other,7,1,3,915.9189999999995,No,,4IPF,1F0,31128449,8,No,,Reviewed,Q00987,No,No,No,No,6,131.92999999999998
+1067,O=C(C(N(CC1=C2C=CC=C1C#CCCCCC(N3CCN(C(N4C(C5=CC=C(Cl)C=C5)C(C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)=O)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.871700000000006,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,7,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCCCC=O,Other,8,1,4,929.9459999999996,No,,4IPF,1F0,31128449,9,No,,Reviewed,Q00987,No,No,No,No,6,131.92999999999998
+1068,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3N4CCN(C(N5C(C6=CC=C(Cl)C=C6)C(C7=CC=C(Cl)C=C7)N=C5C8=CC=C(C(C)(C)C)C=C8OCC)=O)CC4)=O,Inactive,No,RS4;11,7.57780000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,8,1,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,None,Other,0,0,0,835.7889999999998,No,,4IPF,1F0,31128449,25,No,,Reviewed,Q00987,No,No,No,No,6,131.92999999999998
+1069,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCC(N4CCN(C(N5C(C6=CC=C(Cl)C=C6)C(C7=CC=C(Cl)C=C7)N=C5C8=CC=C(C(C)(C)C)C=C8OCC)=O)CC4)=O)=O,Inactive,No,RS4;11,7.01190000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_amide,9,2,,,RG7112 analogue,O=C(N1CCNCC1)N2C(C3=CC=C(Cl)C=C3)C(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,CC=O,Other,3,1,0,892.8409999999998,No,,4IPF,1F0,31128449,26,No,,Reviewed,Q00987,No,No,No,No,6,161.02999999999997
+1070,O=C(C(N(CC1=C2C=CC=C1C#CCN3CCN(C(N4[C@H](C5=CC=C(Cl)C=C5)[C@H](C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Active,Yes,RS4;11,7.784700000000009,,Yangwode Jing,23 nM,90 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,3.2 nM,amine_to_methylamine,7,1,,,"(4S,5R)-RG7112 analogue",O=C(N1CCNCC1)N2[C@H](C3=CC=C(Cl)C=C3)[C@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CC,Other,3,0,0,859.8549999999994,No,,4IPF,1F0,31128449,32,No,,Reviewed,Q00987,No,Yes,No,Yes,6,114.85999999999999
+1071,O=C(C(N(CC1=C2C=CC=C1C#CCCN3CCN(C(N4[C@H](C5=CC=C(Cl)C=C5)[C@H](C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.17480000000001,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,7,1,,,"(4S,5R)-RG7112 analogue",O=C(N1CCNCC1)N2[C@H](C3=CC=C(Cl)C=C3)[C@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCC,Other,4,0,0,873.8819999999994,No,,4IPF,1F0,31128449,33,No,,Reviewed,Q00987,No,No,No,No,6,114.85999999999999
+1072,O=C(C(N(CC1=C2C=CC=C1C#CCCCN3CCN(C(N4[C@H](C5=CC=C(Cl)C=C5)[C@H](C6=CC=C(Cl)C=C6)N=C4C7=CC=C(C(C)(C)C)C=C7OCC)=O)CC3)C2=O)CC8)NC8=O,Inactive,No,RS4;11,8.564900000000009,,Yangwode Jing,,,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,amine_to_methylamine,7,1,,,"(4S,5R)-RG7112 analogue",O=C(N1CCNCC1)N2[C@H](C3=CC=C(Cl)C=C3)[C@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC,C#CCCC,Other,5,0,1,887.9089999999994,No,,4IPF,1F0,31128449,34,No,,Reviewed,Q00987,No,No,No,No,6,114.85999999999999
+1073,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCN4CCN(C5=CC=C(NC6=NC=C7C(N(C8=NC(C(C)(O)C)=CC=C8)N(CC=C)C7=O)=N6)C=C5)CC4)=O,Active,Yes,MOLT4; BT549; HCC1806; COV362; Kuramochi; OVCAR8,3.159600000000002,IC50 for AZD1175: 1.52±0.17 nM; IC50 for ZNL-02-096: 3.58±0.36 nM,"Yangwode Jing, Ronen Gabizon",~ 10 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,800 nM,390 nM,aliphatic_CC,15,4,1.52 nM,3.58 nM,AZD1775,O=C1N(CC=C)N(C2=NC(C(C)(O)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C31,CC,Alkane,2,0,0,799.8929999999999,No,,5V5Y,8X7,31735695,ZNL-02-096,Yes,,Reviewed,P30291,Yes,Yes,No,Yes,"0.25, 0.5, 1, 2, 3, 4, 5, 24, 48",199.92000000000002
+1074,O=C(NCCCN1CCN(C2=CC=C(NC3=NC=C4C(N(C5=NC(C(C)(O)C)=CC=C5)N(CC=C)C4=O)=N3)C=C2)CC1)CCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,MOLT4,2.699100000000005,IC50: 7.28±0.67 nM,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,800 nM,,aliphatic_CC,18,5,1.52 nM,7.28 nM,AZD1775,O=C1N(CC=C)N(C2=NC(C(C)(O)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C31,CCNC(=O)CCOCCOCC,PEG,13,4,8,959.0779999999995,No,,5V5Y,8X7,31735695,ZNL-02-012,No,,Reviewed,P30291,No,No,No,No,5,247.47999999999996
+1075,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN4CCN(C5=CC=C(NC6=NC=C7C(N(C8=NC(C(C)(O)C)=CC=C8)N(CC=C)C7=O)=N6)C=C5)CC4)=O,Active,No,MOLT4,2.8193000000000037,IC50: 3.18±0.52 nM,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,800 nM,,aliphatic_CC,18,4,1.52 nM,3.18 nM,AZD1775,O=C1N(CC=C)N(C2=NC(C(C)(O)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C31,CCOCCOCCOC,PEG,10,3,7,918.0249999999999,No,,5V5Y,8X7,31735695,ZNL-02-047,No,,Reviewed,P30291,No,No,No,No,5,227.61
+1076,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCN4CCN(C5=CC=C(NC6=NC=C7C(N(C8=NC(C(C)(O)C)=CC=C8)N(CC=C)C7=O)=N6)C=C5)CC4)=O,Active,No,MOLT4,4.329900000000002,IC50: 4.46±0.95 nM,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,800 nM,,aliphatic_CC,15,4,1.52 nM,4.46 nM,AZD1775,O=C1N(CC=C)N(C2=NC(C(C)(O)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C31,CCCCC,Alkane,5,0,2,841.9739999999998,No,,5V5Y,8X7,31735695,ZNL-02-040,No,,Reviewed,P30291,No,No,No,No,5,199.92000000000002
+1077,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,Yes,SRD15; Huh7,6.496400000000007,,Yangwode Jing,0.1 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCO)nn1,PEG,23,8,16,1159.2789999999993,No,,1HWK,117,32321253,P22A,Yes,,Reviewed,P04035,Yes,Yes,No,Yes,"4, 5, 16",284.22999999999996
+1078,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.446600000000005,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,15,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCn1cc(CCCO)nn1,PEG,14,5,7,1027.1199999999997,No,,1HWK,117,32321253,P13A,No,,Reviewed,P04035,No,No,No,No,16,256.53999999999996
+1079,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.836700000000007,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,15,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCn1cc(CCCCO)nn1,PEG,15,5,8,1041.1469999999995,No,,1HWK,117,32321253,P14A,No,,Reviewed,P04035,No,No,No,No,16,256.53999999999996
+1080,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.226800000000007,,Yangwode Jing,3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,15,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCn1cc(CCCCCO)nn1,PEG,16,5,9,1055.1739999999995,No,,1HWK,117,32321253,P15A,No,,Reviewed,P04035,No,No,No,No,16,256.53999999999996
+1081,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.463200000000006,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,16,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCn1cc(CCCO)nn1,PEG,17,6,10,1071.1729999999995,No,,1HWK,117,32321253,P16A,No,,Reviewed,P04035,No,No,No,No,16,265.77
+1082,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.853300000000006,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,16,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCn1cc(CCCCO)nn1,PEG,18,6,11,1085.1999999999994,No,,1HWK,117,32321253,P17A,No,,Reviewed,P04035,No,No,No,No,16,265.77
+1083,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.2434000000000065,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,16,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCn1cc(CCCCCO)nn1,PEG,19,6,12,1099.2269999999994,No,,1HWK,117,32321253,P18A,No,,Reviewed,P04035,No,No,No,No,16,265.77
+1084,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.479800000000007,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCO)nn1,PEG,20,7,13,1115.2259999999994,No,,1HWK,117,32321253,P19A,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1085,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.8699000000000074,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCCO)nn1,PEG,21,7,14,1129.2529999999992,No,,1HWK,117,32321253,P20A,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1086,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.260000000000007,,Yangwode Jing,1.8 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCCCO)nn1,PEG,22,7,15,1143.2799999999993,No,,1HWK,117,32321253,P21A,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1087,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,6.886500000000008,,Yangwode Jing,0.4 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCCO)nn1,PEG,24,8,17,1173.3059999999991,No,,1HWK,117,32321253,P23A,No,,Reviewed,P04035,No,No,No,No,16,284.22999999999996
+1088,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.276600000000008,,Yangwode Jing,0.5 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCCCO)nn1,PEG,25,8,18,1187.3329999999994,No,,1HWK,117,32321253,P24A,No,,Reviewed,P04035,No,No,No,No,16,284.22999999999996
+1089,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,6.513000000000006,,Yangwode Jing,0.2 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,19,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCOCCn1cc(CCCO)nn1,PEG,26,9,19,1203.3319999999992,No,,1HWK,117,32321253,P25A,No,,Reviewed,P04035,No,No,No,No,16,293.4599999999999
+1090,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.293200000000008,,Yangwode Jing,0.6 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,19,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCOCCn1cc(CCCCCO)nn1,PEG,28,9,21,1231.3859999999993,No,,1HWK,117,32321253,P27A,No,,Reviewed,P04035,No,No,No,No,16,293.4599999999999
+1091,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.947900000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CO)nn1,Alkane,14,4,7,1025.1479999999997,No,,1HWK,117,32321253,P13A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1092,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.990400000000008,,Yangwode Jing,0.4 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCn1cc(CCCO)nn1,Alkane,15,4,8,1039.1749999999995,No,,1HWK,117,32321253,P14A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1093,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.380500000000005,,Yangwode Jing,0.2 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CCCO)nn1,Alkane,16,4,9,1053.2019999999995,No,,1HWK,117,32321253,P15A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1094,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.770600000000004,,Yangwode Jing,0.3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CCCCO)nn1,Alkane,17,4,10,1067.2289999999994,No,,1HWK,117,32321253,P16A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1095,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,9.160700000000002,,Yangwode Jing,0.4 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CCCCCO)nn1,Alkane,18,4,11,1081.2559999999992,No,,1HWK,117,32321253,P17A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1096,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,9.5508,,Yangwode Jing,0.3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CCCCCCO)nn1,Alkane,19,4,12,1095.2829999999992,No,,1HWK,117,32321253,P18A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1097,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCCCC4=CN(CCCCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,9.940900000000001,,Yangwode Jing,0.5 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,14,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCCCCCn1cc(CCCCCCCO)nn1,Alkane,20,4,13,1109.3099999999993,No,,1HWK,117,32321253,P19A1,No,,Reviewed,P04035,No,No,No,No,16,247.30999999999997
+1098,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.479800000000007,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCO)nn1,PEG,20,7,13,1115.2259999999994,No,,1HWK,117,32321253,P19AM,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1099,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.8699000000000074,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCCO)nn1,PEG,21,7,14,1129.2529999999992,No,,1HWK,117,32321253,P20AM,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1100,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.260000000000008,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,17,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCn1cc(CCCCCO)nn1,PEG,22,7,15,1143.2799999999993,No,,1HWK,117,32321253,P21AM,No,,Reviewed,P04035,No,No,No,No,16,274.99999999999994
+1101,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,6.496400000000007,,Yangwode Jing,0.3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCO)nn1,PEG,23,8,16,1159.2789999999993,No,,1HWK,117,32321253,P22AM,No,,Reviewed,P04035,No,No,No,No,16,284.22999999999996
+1102,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCC4=CN(CCOCCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.886500000000008,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCCO)nn1,PEG,24,8,17,1173.3059999999991,No,,1HWK,117,32321253,P23AM,No,,Reviewed,P04035,No,No,No,No,16,284.22999999999996
+1103,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCCCC4=CN(CCOCCOCCOCCOCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.276600000000008,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,18,6,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCOCCOCCOCCOCCn1cc(CCCCCO)nn1,PEG,25,8,18,1187.3329999999994,No,,1HWK,117,32321253,P24AM,No,,Reviewed,P04035,No,No,No,No,16,284.22999999999996
+1104,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,6.746000000000007,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCn1cc(CCCO)nn1,Other,15,5,7,1008.1169999999997,No,,1HWK,117,32321253,L13A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1105,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.136100000000007,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCCn1cc(CCCO)nn1,Other,16,5,8,1022.1439999999997,No,,1HWK,117,32321253,L14A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1106,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.526200000000008,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCCCn1cc(CCCO)nn1,Other,17,5,9,1036.1709999999996,No,,1HWK,117,32321253,L15A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1107,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,7.9163000000000086,,Yangwode Jing,0.3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCCCCn1cc(CCCO)nn1,Other,18,5,10,1050.1979999999994,No,,1HWK,117,32321253,L16A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1108,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.306400000000007,,Yangwode Jing,0.2 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCCCCCn1cc(CCCO)nn1,Other,19,5,11,1064.2249999999995,No,,1HWK,117,32321253,L17A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1109,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCCOCC#CC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.696500000000006,,Yangwode Jing,0.7 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,C#CCOCCCCCCCn1cc(CCCO)nn1,Other,20,5,12,1078.2519999999993,No,,1HWK,117,32321253,L18A,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1110,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.327100000000008,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCn1cc(CCCO)nn1,Other,15,5,8,1012.1489999999997,No,,1HWK,117,32321253,L13AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1111,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,7.717200000000009,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCCn1cc(CCCO)nn1,Other,16,5,9,1026.1759999999995,No,,1HWK,117,32321253,L14AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1112,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Inactive,No,SRD15,8.10730000000001,,Yangwode Jing,> 3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCCCn1cc(CCCO)nn1,Other,17,5,10,1040.2029999999995,No,,1HWK,117,32321253,L15AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1113,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.497400000000006,,Yangwode Jing,2.3 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCCCCn1cc(CCCO)nn1,Other,18,5,11,1054.2299999999993,No,,1HWK,117,32321253,L16AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1114,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,8.887500000000003,,Yangwode Jing,0.5 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCCCCCn1cc(CCCO)nn1,Other,19,5,12,1068.2569999999994,No,,1HWK,117,32321253,L17AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1115,O=C(O)C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC(OCCCC4=CN(CCCCCCCOCCCC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O)N=N4)=C3)C(C(NC8=CC=CC=C8)=O)=C1C(C)C,Active,No,SRD15,9.277600000000001,,Yangwode Jing,0.6 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aryl_O,13,5,,,Atorvastatin,O=C(C[C@@H](C[C@@H](CCN1C(C2=CC=C(F)C=C2)=C(C(C(NC3=CC=CC=C3)=O)=C1C(C)C)C4=CC=CC=C4)O)O)O,CCCOCCCCCCCn1cc(CCCO)nn1,Other,20,5,13,1082.2839999999992,No,,1HWK,117,32321253,L18AR,No,,Reviewed,P04035,No,No,No,No,16,227.43999999999997
+1116,O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCN(C(CCCN3N=NC(COCCOCCOC4=CC=CC(C(C5=CSC([C@H]6N(C([C@@H](C7CCCCC7)NC([C@@H](NC)C)=O)=O)CCC6)=N5)=O)=C4)=C3)=O)CC2)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C1)=O)C9=CC=C(N%10CCN(CC%11=C(C%12=CC=C(Cl)C=C%12)CCC(C)(C)C%11)CC%10)C=C9,Active,No,MyLa1929,12.353299999999988,,Yangwode Jing,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,157 nM,morpholine_to_piperazine,23,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCn1cc(COCCOCCO)nn1,PEG,19,8,11,1709.5579999999998,No,,6QGH,1XJ,32388279,3a,No,,Reviewed,Q07817,No,No,No,No,72,289.24
+1117,O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCN(C(CCCN3N=NC(COCCOCCOCCOC4=CC=CC(C(C5=CSC([C@H]6N(C([C@@H](C7CCCCC7)NC([C@@H](NC)C)=O)=O)CCC6)=N5)=O)=C4)=C3)=O)CC2)CSC8=CC=CC=C8)C(S(=O)(C(F)(F)F)=O)=C1)=O)C9=CC=C(N%10CCN(CC%11=C(C%12=CC=C(Cl)C=C%12)CCC(C)(C)C%11)CC%10)C=C9,Active,No,MyLa1929,12.369899999999989,,Yangwode Jing,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,147 nM,morpholine_to_piperazine,24,4,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCn1cc(COCCOCCOCCO)nn1,PEG,22,9,14,1753.6109999999999,No,,4QNQ,1XJ,32388279,3b,No,,Reviewed,Q07817,No,No,No,No,72,298.47
+1119,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(COCCOCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Active,No,MyLa1929,11.78139999999999,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,143 nM,morpholine_to_piperazine,20,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)COCCOCCO,PEG,11,5,7,1600.4260000000002,,,4QNQ,1XJ,32388279,4a,No,,Reviewed,Q07817,No,No,No,No,72,258.53
+1120,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(COCCOCCOCCOCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Active,No,MyLa1929,11.81459999999999,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,75 nM,morpholine_to_piperazine,22,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)COCCOCCOCCOCCO,PEG,17,7,13,1688.5320000000004,,,4QNQ,1XJ,32388279,4b,No,,Reviewed,Q07817,No,No,No,No,72,276.98999999999995
+1121,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Active,No,MyLa1929,12.528399999999987,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,997 nM,morpholine_to_piperazine,18,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCO,Alkane,7,3,3,1540.3739999999998,,,4QNQ,1XJ,32388279,5a,No,,Reviewed,Q07817,No,No,No,No,72,240.06999999999994
+1122,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Active,No,MyLa1929,12.918499999999986,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,1959 nM,morpholine_to_piperazine,18,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCO,Alkane,8,3,4,1554.4009999999998,,,4QNQ,1XJ,32388279,5b,No,,Reviewed,Q07817,No,No,No,No,72,240.06999999999994
+1123,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Inactive,No,MyLa1929,13.308599999999982,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,,morpholine_to_piperazine,18,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCCO,Alkane,9,3,5,1568.4279999999999,,,4QNQ,1XJ,32388279,5c,No,,Reviewed,Q07817,No,No,No,No,72,240.06999999999994
+1124,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCCCOC8=CC=CC(C(C9=CSC([C@H]%10N(CCC%10)C([C@H](NC([C@H](C)NC)=O)C%11CCCCC%11)=O)=N9)=O)=C8)=O)=O,Inactive,No,MyLa1929,13.698699999999981,,Ronen Gabizon,,,C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=C(F)C=C4)=O)=CS3)CCC2)=O)=O,Iap,,,morpholine_to_piperazine,18,4,,, ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,NC(=O)CCCCCCO,Alkane,10,3,6,1582.455,,,4QNQ,1XJ,32388279,5d,No,,Reviewed,Q07817,No,No,No,No,72,240.06999999999994
+1125,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCN8N=NC(COCCOCCOC9=CC=C%10C(CCC[C@H]%10NC([C@H]%11C(C)(C)C[C@@]([H])(OCC[C@H]%12NC([C@@H](C)NC)=O)N%11C%12=O)=O)=C9)=C8)=O)=O,Active,No,MyLa1929,10.289100000000001,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,153 nM,morpholine_to_piperazine,22,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCc1cn(CCCC(N)=O)nn1,non-PEG polyether,18,7,10,1683.495,,,4QNQ,1XJ,32388279,6a,No,,Reviewed,Q07817,No,No,No,No,72,297.60999999999996
+1126,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCN8N=NC(COCCOCCOCCOC9=CC=C%10C(CCC[C@H]%10NC([C@H]%11C(C)(C)C[C@@]([H])(OCC[C@H]%12NC([C@@H](C)NC)=O)N%11C%12=O)=O)=C9)=C8)=O)=O,Active,No,MyLa1929,10.305700000000002,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,119 nM,morpholine_to_piperazine,23,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCCOCc1cn(CCCC(N)=O)nn1,non-PEG polyether,21,8,13,1727.548,,,4QNQ,1XJ,32388279,6b,No,,Reviewed,Q07817,No,No,No,No,72,306.8399999999999
+1127,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(COCCOCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,9.717200000000004,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,100 nM,morpholine_to_piperazine,19,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCOCCOCC(N)=O,PEG,10,4,6,1574.3629999999998,,,4QNQ,1XJ,32388279,7a,No,,Reviewed,Q07817,No,No,No,No,72,266.9
+1128,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(COCCOCCOCCOCCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,10.140500000000005,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,70 nM,morpholine_to_piperazine,21,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCOCCOCCOCCOCC(N)=O,PEG,17,6,13,1676.496,,,4QNQ,1XJ,32388279,7b,No,,Reviewed,Q07817,No,No,No,No,72,285.35999999999996
+1129,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,10.464199999999998,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,62 nM,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCC(N)=O,Alkane,6,2,2,1514.3109999999995,,,4QNQ,1XJ,32388279,8a,No,,Reviewed,Q07817,No,No,No,No,72,248.43999999999997
+1130,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,10.854299999999995,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,76 nM,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCC(N)=O,Alkane,7,2,3,1528.3379999999995,,,4QNQ,1XJ,32388279,8b,No,,Reviewed,Q07817,No,No,No,No,72,248.43999999999997
+1131,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,11.244399999999994,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,127 nM,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCC(N)=O,Alkane,8,2,4,1542.3649999999996,,,4QNQ,1XJ,32388279,8c,No,,Reviewed,Q07817,No,No,No,No,72,248.43999999999997
+1132,O=C(C1=CC=C(C=C1)N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(C=C4)Cl)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@@H](CSC6=CC=CC=C6)CCN7CCN(CC7)C(CCCCCCOC8=CC=C9C(CCC[C@H]9NC([C@H]%10C(C)(C)C[C@@]([H])(OCC[C@H]%11NC([C@@H](C)NC)=O)N%10C%11=O)=O)=C8)=O)=O,Active,No,MyLa1929,11.634499999999992,,Ronen Gabizon,,,O=C([C@H]1C(C)(C)C[C@@]([H])(OCC[C@H]2NC([C@@H](C)NC)=O)N1C2=O)N[C@@H]3CCCC4=CC(O)=CC=C43,Iap,,274 nM,morpholine_to_piperazine,17,5,,,ABT-263,CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1,CCCCCCC(N)=O,Alkane,9,2,5,1556.3919999999996,,,4QNQ,1XJ,32388279,8d,No,,Reviewed,Q07817,No,No,No,No,72,248.43999999999997
+1133,O=C(NCCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Active,Yes,"SW480, HCT116",4.257760000000003,,Yangwode Jing,3.6 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,8 uM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCCCCCC,Alkane,8,0,5,722.8470000000001,No,,5E80,5KP,32603594,17f,No,,Reviewed,O43924,No,Yes,No,Yes,"1, 2, 4, 8, 24",177.39
+1134,O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C(CCCC6=CN(CCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)N=N6)=O)CC5)C=C4,Inactive,No,K562,4.614820000000002,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,4,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCc1cn(CC)nn1,Other,10,3,3,916.0159999999997,No,,2HYY,STI,32657579,P10Im,No,,Reviewed,P00519,No,No,No,No,32,229.63999999999993
+1135,O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C(CCCC6=CN(CCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)N=N6)=O)CC5)C=C4,Inactive,No,K562,4.631420000000002,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,4,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCc1cn(CCOCC)nn1,Other,13,4,6,960.0689999999996,No,,2HYY,STI,32657579,P13Im,No,,Reviewed,P00519,No,No,No,No,32,238.86999999999995
+1136,O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C(CCCC6=CN(CCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)N=N6)=O)CC5)C=C4,Inactive,No,K562,4.648020000000003,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,17,4,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCc1cn(CCOCCOCC)nn1,PEG,16,5,9,1004.1219999999995,No,,2HYY,STI,32657579,P16Im,No,,Reviewed,P00519,No,No,No,No,32,248.0999999999999
+1137,O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C(CCCC6=CN(CCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)N=N6)=O)CC5)C=C4,Inactive,No,K562,4.664620000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,18,4,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCc1cn(CCOCCOCCOCC)nn1,PEG,19,6,12,1048.1749999999995,No,,2HYY,STI,32657579,P19Im,No,,Reviewed,P00519,No,No,No,No,32,257.3299999999999
+1138,O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C(CCCC6=CN(CCOCCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)N=N6)=O)CC5)C=C4,Inactive,No,K562,4.681220000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,19,4,,,imatinib,Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1,CCCc1cn(CCOCCOCCOCCOCC)nn1,PEG,22,7,15,1092.2279999999994,No,,2HYY,STI,32657579,P20Im,No,,Reviewed,P00519,No,No,No,No,32,266.55999999999995
+1139,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(C(CCCC4=CN(CCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)=C2)S1)NC8=C(C)C=CC=C8Cl,Active,No,K562,3.9755400000000023,,Yangwode Jing,~ 56 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,16,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCc1cn(CC)nn1,Other,9,3,2,880.392,No,,2GQG,1N1,32657579,P10D,No,,Reviewed,P00519,No,No,No,No,32,229.63999999999996
+1140,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(C(CCCC4=CN(CCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)=C2)S1)NC8=C(C)C=CC=C8Cl,Active,No,K562,3.992140000000002,,Yangwode Jing,~ 56 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,17,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOCCn1cc(CC)nn1,Other,12,4,5,924.4449999999998,No,,2GQG,1N1,32657579,P13D,No,,Reviewed,P00519,No,No,No,No,32,238.86999999999998
+1141,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(C(CCCC4=CN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)=C2)S1)NC8=C(C)C=CC=C8Cl,Active,No,K562,4.008740000000004,,Yangwode Jing,~ 20 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,18,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOCCOCCn1cc(CC)nn1,PEG,15,5,8,968.4979999999998,No,,2GQG,1N1,32657579,P16D,No,,Reviewed,P00519,No,No,No,No,32,248.1
+1142,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(C(CCCC4=CN(CCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)=C2)S1)NC8=C(C)C=CC=C8Cl,Active,No,K562,4.025340000000007,,Yangwode Jing,~ 56 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,hydroxyl_to_carbon,19,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOCCOCCOCCn1cc(CC)nn1,PEG,18,6,11,1012.5509999999999,No,,2GQG,1N1,32657579,P19D,No,,Reviewed,P00519,No,No,No,No,32,257.3299999999999
+1143,O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(C(CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)=C2)S1)NC8=C(C)C=CC=C8Cl,Active,No,K562,4.041940000000007,,Yangwode Jing,~ 10 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,9.2 nM,hydroxyl_to_carbon,20,4,,,Dasatinib,Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1,CCOCCOCCOCCOCCn1cc(CC)nn1,PEG,21,7,14,1056.6039999999998,No,,2GQG,1N1,32657579,P22D,No,,Reviewed,P00519,No,No,No,No,32,266.55999999999995
+1144,O=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](NC(CCCC4=CN(CCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)C(C8=NNC=C8)=C2,Active,No,K562,3.714500000000001,,Yangwode Jing,> 625 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,14,5,,,Asciminib,O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4,CCn1cc(CCCC(N)=O)nn1,Other,13,5,5,885.2889999999998,No,,5MO4,AY7,32657579,P10As,No,,Reviewed,P00519,No,No,No,No,32,238.52999999999994
+1145,O=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](NC(CCCC4=CN(CCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)C(C8=NNC=C8)=C2,Active,No,K562,3.7311000000000014,,Yangwode Jing,~ 400 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,15,5,,,Asciminib,O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4,CCOCCn1cc(CCCC(N)=O)nn1,Other,16,6,8,929.3419999999998,No,,5MO4,AY7,32657579,P13As,No,,Reviewed,P00519,No,No,No,No,32,247.7599999999999
+1146,O=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](NC(CCCC4=CN(CCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)C(C8=NNC=C8)=C2,Active,No,K562,3.747700000000002,,Yangwode Jing,~ 300 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,16,5,,,Asciminib,O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4,CCOCCOCCn1cc(CCCC(N)=O)nn1,PEG,19,7,11,973.3949999999996,No,,5MO4,AY7,32657579,P16As,No,,Reviewed,P00519,No,No,No,No,32,256.98999999999995
+1147,O=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](NC(CCCC4=CN(CCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)C(C8=NNC=C8)=C2,Active,No,K562,3.764300000000002,,Yangwode Jing,~ 200 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,121 nM,other,17,5,,,Asciminib,O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4,CCOCCOCCOCCn1cc(CCCC(N)=O)nn1,PEG,22,8,14,1017.4479999999995,No,,5MO4,AY7,32657579,P19As,No,,Reviewed,P00519,No,No,No,No,32,266.21999999999997
+1148,O=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](NC(CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)=O)CC3)C(C8=NNC=C8)=C2,Active,No,K562,3.7809000000000026,,Yangwode Jing,~ 500 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,18,5,,,Asciminib,O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4,CCOCCOCCOCCOCCn1cc(CCCC(N)=O)nn1,PEG,25,9,17,1061.5009999999995,No,,5MO4,AY7,32657579,P22As,No,,Reviewed,P00519,No,No,No,No,32,275.44999999999993
+1149,O=C(NC1=CC=C(CN2CCN(C(CCCC3=CN(CCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)N=N3)=O)CC2)C(C(F)(F)F)=C1)C7=CC=C(C)C(C#CC8=CN=C9C=CC=NN98)=C7,Active,No,K562,4.480520000000004,,Yangwode Jing,~ 625 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,14,3,,,Ponatinib,CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C=C3)C)=O,CCCc1cn(CC)nn1,Other,10,3,3,954.9709999999997,No,,3IK3,0LI,32657579,P10P,No,,Reviewed,P00519,No,No,No,No,32,209.1299999999999
+1150,O=C(NC1=CC=C(CN2CCN(C(CCCC3=CN(CCOCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)N=N3)=O)CC2)C(C(F)(F)F)=C1)C7=CC=C(C)C(C#CC8=CN=C9C=CC=NN98)=C7,Active,No,K562,4.497120000000003,,Yangwode Jing,~ 70 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,,,Ponatinib,CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C=C3)C)=O,CCCc1cn(CCOCC)nn1,Other,13,4,6,999.0239999999998,No,,3IK3,0LI,32657579,P13P,No,,Reviewed,P00519,No,No,No,No,32,218.35999999999993
+1151,O=C(NC1=CC=C(CN2CCN(C(CCCC3=CN(CCOCCOCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)N=N3)=O)CC2)C(C(F)(F)F)=C1)C7=CC=C(C)C(C#CC8=CN=C9C=CC=NN98)=C7,Active,No,K562,4.513720000000005,,Yangwode Jing,~ 70 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,3,,,Ponatinib,CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C=C3)C)=O,CCCc1cn(CCOCCOCC)nn1,PEG,16,5,9,1043.0769999999998,No,,3IK3,0LI,32657579,P16P,No,,Reviewed,P00519,No,No,No,No,32,227.58999999999995
+1152,O=C(NC1=CC=C(CN2CCN(C(CCCC3=CN(CCOCCOCCOCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)N=N3)=O)CC2)C(C(F)(F)F)=C1)C7=CC=C(C)C(C#CC8=CN=C9C=CC=NN98)=C7,Active,No,K562,4.530320000000007,,Yangwode Jing,~ 20 nM,50 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,7.5 nM,aliphatic_CC,17,3,,,Ponatinib,CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C=C3)C)=O,CCCc1cn(CCOCCOCCOCC)nn1,PEG,19,6,12,1087.1299999999999,No,,3IK3,0LI,32657579,P19P,No,,Reviewed,P00519,No,No,No,No,32,236.81999999999996
+1153,O=C(NC1=CC=C(CN2CCN(C(CCCC3=CN(CCOCCOCCOCCOCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)N=N3)=O)CC2)C(C(F)(F)F)=C1)C7=CC=C(C)C(C#CC8=CN=C9C=CC=NN98)=C7,Active,No,K562,4.54692000000001,,Yangwode Jing,~ 70 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,18,3,,,Ponatinib,CN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C=C3)C)=O,CCCc1cn(CCOCCOCCOCCOCC)nn1,PEG,22,7,15,1131.183,No,,3IK3,0LI,32657579,P22P,No,,Reviewed,P00519,No,No,No,No,32,246.04999999999993
+1154,O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN4N=NC(CCCC(N5CCN(C6=NC(C)=NC(NC7=NC=C(/C=C/C8=CC=CC(C)=C8)S7)=C6)CC5)=O)=C4)=O,Active,Yes,"K562, BaF3",4.306640000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,0.45 uM,6.1 uM,other,19,3,,,Dasatinib analogue,O=C(N1CCN(C2=NC(C)=NC(NC3=NC=C(/C=C/C4=CC=CC(C)=C4)S3)=C2)CC1)CCCC#C,cn(CCOCCOCCOCCOCC)nn,PEG,18,7,13,1005.1719999999996,No,,2GQG,1N1,32657579,P22D1,No,,Reviewed,P00519,No,No,No,No,48,237.45999999999998
+1155,O=C(NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(C)C(N5C(C)=CC(OCC6=CC=C(F)C=C6F)=C(Br)C5=O)=C4,Inactive,No,"BBL358, T47D",5.097340000000005,"Dmax in BBL358/T47D: 8% and 0, respectively.",Yangwode Jing,,8 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCC,Alkane,3,0,0,790.6180000000003,No,,3HLL,I45,32634680,NR-1a,No,,Reviewed,Q16539,No,No,No,No,24,155.90999999999997
+1156,O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCCCNC(C4=CC=C(C)C(N5C(C)=CC(OCC6=CC=C(F)C=C6F)=C(Br)C5=O)=C4)=O,Active,No,"BBL358, T47D",4.415240000000003,"Dmax in BBL358/T47D: 40%±27% and 0, respectively.",Yangwode Jing,,40 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,9,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCC,Alkane,3,0,0,818.6280000000003,No,,3HLL,I45,32634680,NR-2a,No,,Reviewed,Q16539,No,No,No,No,24,172.98
+1157,O=C(NCCOCCOCCOCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(C)C(N5C(C)=CC(OCC6=CC=C(F)C=C6F)=C(Br)C5=O)=C4,Active,No,"BBL358, T47D",4.416740000000008,,Yangwode Jing,,60 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCOCCOCCOCCOCCOCCOC,PEG,19,6,16,1026.882,No,,3HLL,I45,32634680,NR-1c,No,,Reviewed,Q16539,No,No,No,No,24,211.29
+1158,O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C4=CC=C(C)C(N5C(C)=CC(OCC6=CC=C(F)C=C6F)=C(Br)C5=O)=C4,Active,No,"BBL358, T47D",4.350340000000004,,Yangwode Jing,,60 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCOCCOC,PEG,7,2,4,850.6700000000002,No,,3HLL,I45,32634680,NR-1b,No,,Reviewed,Q16539,No,No,No,No,24,174.36999999999998
+1159,O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCOCCOCCNC(C4=CC=C(C)C(N5C(C)=CC(OCC6=CC=C(F)C=C6F)=C(Br)C5=O)=C4)=O,Active,No,"BBL358, T47D",3.6682400000000035,,Yangwode Jing,,55 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCOCCOC,PEG,7,2,4,878.6800000000002,No,,3HLL,I45,32634680,NR-2b,No,,Reviewed,Q16539,No,No,No,No,24,191.44
+1160,O=C(NCCCCC1=CN(CCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.981340000000006,,Yangwode Jing,,78 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCOCCOCCOCC)nn1,PEG,19,6,12,1017.8819999999997,No,,3HLL,I45,32634680,NR-3a,No,,Reviewed,Q16539,No,No,No,No,24,214.30999999999997
+1161,O=C(NCCCCC1=CN(CCOCCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.997940000000009,,Yangwode Jing,,92 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,16,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCOCCOCCOCCOCC)nn1,PEG,22,7,15,1061.935,No,,3HLL,I45,32634680,NR-3b,No,,Reviewed,Q16539,No,No,No,No,24,223.54
+1162,O=C(NCCCCC1=CN(CCCC(NCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.861140000000009,,Yangwode Jing,,79 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCCC(=O)NCCOCCOCC)nn1,PEG,22,7,13,1058.935,No,,3HLL,I45,32634680,NR-3c,No,,Reviewed,Q16539,No,No,No,No,24,234.17999999999998
+1163,O=C(NCCCCC1=CN(CCCC(NCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(N(CC5=CC=CC=C5[N+]([O-])=O)C4=O)=O)=O)=C2C3=O)=O)N=N1)C6=CC=C(C)C(N7C(C)=CC(OCC8=CC=C(F)C=C8F)=C(Br)C7=O)=C6,Inactive,No,"BBL358, T47D",6.68194000000001,"Dmax in BBL358/T47D: 3%±3% and 20%±20%, respectively.",Yangwode Jing,,3 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,17,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCCC(=O)NCCOCCOCC)nn1,PEG,22,7,13,1194.057,No,,3HLL,I45,32634680,NR-3d,No,,Reviewed,Q16539,No,No,No,No,24,268.53
+1164,O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCOCCOCCNC(CCCN4N=NC(CCCCNC(C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5)=O)=C4)=O,Active,No,"BBL358, T47D",4.179040000000007,"Dmax in BBL358/T47D: 0.5% and 76%, respectively.",Yangwode Jing,,76 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCCC(=O)NCCOCCOCC)nn1,PEG,22,7,13,1086.9449999999997,No,,3HLL,I45,32634680,NR-4,No,,Reviewed,Q16539,No,No,No,No,24,251.25
+1165,O=C(NCCCCC1=CN(CCCC(NCCCCCCC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",6.518940000000007,"Dmax in BBL358/T47D: 67%±17% and 47%±32%, respectively.",Yangwode Jing,,67 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCCCNC(=O)CCCn1cc(CCC)nn1,Alkane,20,5,11,1011.9219999999999,No,,3HLL,I45,32634680,NR-5a,No,,Reviewed,Q16539,No,No,No,No,24,203.68999999999997
+1166,O=C(NCCCCC1=CN(CCCC(NCCCCCC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",6.128840000000007,"Dmax in BBL358/T47D: 77%±3% and 82%±10%, respectively.",Yangwode Jing,,77 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,12,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCCNC(=O)CCCn1cc(CCC)nn1,Alkane,19,5,10,997.8949999999999,No,,3HLL,I45,32634680,NR-5b,No,,Reviewed,Q16539,No,No,No,No,24,203.68999999999997
+1167,O=C(NCCCCC1=CN(CCCC(NCCCCCCC2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,Yes,"BBL358, T47D",6.878740000000008,"Dmax in BBL358/T47D: 93%±5% and 87%±3%, respectively.",Yangwode Jing,,93 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCCCNC(=O)CCCn1cc(CCC)nn1,Alkane,20,5,11,997.939,No,,3HLL,I45,32634680,NR-6a,No,,Reviewed,Q16539,No,No,No,No,24,186.61999999999998
+1168,O=C(NCCCCC1=CN(CCCC(NCCCCCC2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",6.488640000000007,"Dmax in BBL358/T47D: 74%±3% and 16%±13%, respectively.",Yangwode Jing,,74 %,Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,11,3,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCCNC(=O)CCCn1cc(CCC)nn1,Alkane,19,5,10,983.9119999999999,No,,3HLL,I45,32634680,NR-6b,No,,Reviewed,Q16539,No,No,No,No,24,186.61999999999998
+1169,O=C(NCCC1=CN(CCCC(NCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Inactive,No,"BBL358, T47D",4.047740000000005,,Yangwode Jing,,0,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCNC(=O)CCCn1cc(C)nn1,Alkane,14,5,5,942.775,No,,3HLL,I45,32634680,NR-7a,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1170,O=C(NCCC1=CN(CCCC(NCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.437840000000004,,Yangwode Jing,,36 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCNC(=O)CCCn1cc(C)nn1,Alkane,15,5,6,956.8019999999999,No,,3HLL,I45,32634680,NR-7b,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1171,O=C(NCCCC1=CN(CCCC(NCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.827940000000005,,Yangwode Jing,,60 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCNC(=O)CCCn1cc(CC)nn1,Alkane,16,5,7,970.8289999999998,No,,3HLL,I45,32634680,NR-7c,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1172,O=C(NCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.827940000000005,,Yangwode Jing,,40 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCNC(=O)CCCn1cc(C)nn1,Alkane,16,5,7,970.8289999999998,No,,3HLL,I45,32634680,NR-7d,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1173,O=C(NCCCCC1=CN(CCCC(NCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",4.827940000000005,,Yangwode Jing,,40 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCc1cn(CCCC(=O)NCC)nn1,Alkane,16,5,7,970.8289999999998,No,,3HLL,I45,32634680,NR-7e,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1174,O=C(NCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",5.218040000000006,,Yangwode Jing,,84 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCNC(=O)CCCn1cc(CC)nn1,Alkane,17,5,8,984.8559999999998,No,,3HLL,I45,32634680,NR-7f,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1175,O=C(NCCCCC1=CN(CCCC(NCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,No,"BBL358, T47D",5.218040000000006,,Yangwode Jing,,74 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCNC(=O)CCCn1cc(CCC)nn1,Alkane,17,5,8,984.8559999999998,No,,3HLL,I45,32634680,NR-7g,No,,Reviewed,Q16539,No,No,No,No,24,215.71999999999994
+1176,O=C(NCCCCC1=CN(CCCC(NCCCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)N=N1)C5=CC=C(C)C(N6C(C)=CC(OCC7=CC=C(F)C=C7F)=C(Br)C6=O)=C5,Active,Yes,"BBL358, T47D",5.608140000000005,"Dmax in BBL358/T47D: 84%±2% and 89%±2%, respectively.",Yangwode Jing,24 nM,84 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCNC(=O)CCCn1cc(CCC)nn1,Alkane,18,5,9,998.8829999999998,No,,3HLL,I45,32634680,NR-7h,Yes,,Reviewed,Q16539,Yes,No,No,No,24,215.71999999999994
+1177,O=C([O-])N(C(C)(C)C)C(CCN1N=NC(CCCCNC(C2=CC=C(C)C(N3C(C)=CC(OCC4=CC=C(F)C=C4F)=C(Br)C3=O)=C2)=O)=C1)C(NCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O,Active,No,"BBL358, T47D",5.030440000000004,,Yangwode Jing,,81 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,15,4,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCNC(=O)C(CCn1cc(CCC)nn1)N(C(=O)[O-])C(C)(C)C,Other,26,8,10,1113.0069999999996,No,,3HLL,I45,32634680,NR-7i,No,,Reviewed,Q16539,No,No,No,No,24,259.09
+1178,[NH3+]C(CCN1N=NC(CCCCNC(C2=CC=C(C)C(N3C(C)=CC(OCC4=CC=C(F)C=C4F)=C(Br)C3=O)=C2)=O)=C1)C(NCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O.[Cl-],Inactive,No,"BBL358, T47D",0.8325400000000056,,Yangwode Jing,,0,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,aliphatic_CC,13,5,,,PH-797804,O=C(NC)C1=CC=C(C)C(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C1,CCCCNC(=O)C([NH3+])CCn1cc(CCC)nn1,Other,19,6,9,1050.3589999999997,No,,3HLL,I45,32634680,NR-7j,No,,Reviewed,Q16539,No,No,No,No,24,243.35999999999999
+1179,O=C(NCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Inactive,No,"SW480, HCT116",2.3072599999999985,,Yangwode Jing,30 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,81 uM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCC,Alkane,3,0,0,652.7120000000002,No,,5E80,5KP,32603594,17a,No,,Reviewed,O43924,No,No,No,No,24,177.39
+1180,O=C(NCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Inactive,No,"SW480, HCT116",2.6973599999999998,,Yangwode Jing,25 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,76 uM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCC,Alkane,4,0,1,666.7390000000003,No,,5E80,5KP,32603594,17b,No,,Reviewed,O43924,No,No,No,No,24,177.39
+1181,O=C(NCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Inactive,No,"SW480, HCT116",3.087460000000001,,Yangwode Jing,22 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,17 uM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCCC,Alkane,5,0,2,680.7660000000002,No,,5E80,5KP,32603594,17c,No,,Reviewed,O43924,No,No,No,No,24,177.39
+1182,O=C(NCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Active,No,"SW480, HCT116",3.4775600000000013,,Yangwode Jing,15 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,15 uM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCCCC,Alkane,6,0,3,694.7930000000002,No,,5E80,5KP,32603594,17d,No,,Reviewed,O43924,No,No,No,No,24,177.39
+1183,O=C(NCCCCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Active,No,"SW480, HCT116",3.8676600000000025,,Yangwode Jing,14 nM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,12 nM,other,11,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCCCCC,Alkane,7,0,4,708.8200000000002,No,,5E80,5KP,32603594,17e,No,,Reviewed,O43924,No,No,No,No,24,177.39
+1184,O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Inactive,No,"SW480, HCT116",1.950360000000004,,Yangwode Jing,30 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,58 uM,other,13,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCOCCOCC,PEG,8,2,5,726.791,No,,5E80,5KP,32603594,17g,No,,Reviewed,O43924,No,No,No,No,24,195.84999999999997
+1185,O=C(NCCCOCCOCCOCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCN4N=C(C)C5=C(C)N(C6=CC=C(C)C=C6)N=C5C4=O,Active,No,"SW480, HCT116",2.7471600000000054,,Yangwode Jing,10 uM,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,56 uM,26 uM,other,14,3,,,PDEδ inhibitor 2,O=C(N)CCCN1N=C(C)C2=C(C)N(C3=CC=C(C)C=C3)N=C2C1=O,CCCOCCOCCOCCC,PEG,13,3,10,798.8979999999996,No,,5E80,5KP,32603594,17h,No,,Reviewed,O43924,No,No,No,No,24,205.07999999999998
+1186,O=C(NCCNC(C1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)=O)CCCC(NC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O,Inactive,No,,5.800620000000006,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,9,4,,> 200 nM,BMS-8,O=C([C@@H]1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)O,NCCNC(=O)CCCC=O,Other,11,4,6,905.8469999999994,No,,5J8O,6GZ,32388281,P1,No,,Reviewed,Q9NZQ7,No,No,No,No,,183.32
+1187,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCC(N4CCN(C(C5N(CC6=CC=C(OCC7=C(C)C(C8=CC=CC=C8)=CC=C7)C(Br)=C6)CCCC5)=O)CC4)=O,Inactive,No,,6.239020000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,9,2,,> 200 nM,BMS-8,O=C([C@@H]1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)O,O=CCCCC(=O)N1CCNCC1,Other,13,4,4,931.8849999999998,No,,5J8O,6GZ,32388281,P2,No,,Reviewed,Q9NZQ7,No,No,No,No,,165.73999999999998
+1188,O=C(C1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)NCCCCNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O,Inactive,No,,6.767720000000007,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,8,3,,197.4 nM,BMS-8,O=C([C@@H]1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)O,CCCCN,Other,5,1,2,820.7849999999997,No,,5J8O,6GZ,32388281,P3,No,,Reviewed,Q9NZQ7,No,No,No,No,,137.14999999999998
+1189,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O,Inactive,No,,7.142200000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,122.5 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCNC(=O)CCCC=O,Other,11,4,6,992.5299999999994,No,,5J8O,6GZ,32388281,P4,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1190,O=C(NCCCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O,Inactive,No,,7.9224000000000085,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,120.8 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCCCNC(=O)CCCC=O,Other,13,4,8,1020.5839999999994,No,,5J8O,6GZ,32388281,P5,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1191,O=C(NCCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O,Inactive,No,,7.142200000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,> 200 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCCNC(=O)CCC=O,Other,11,4,6,992.5299999999995,No,,5J8O,6GZ,32388281,P6,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1192,O=C(NCCCCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O,Inactive,No,,8.312500000000009,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,> 200 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCCCCNC(=O)CCCC=O,Other,14,4,9,1034.6109999999992,,,5J8O,6GZ,32388281,P7,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1193,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCCC(NC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O,Inactive,No,,7.142200000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,101.9 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCNC(=O)CCCC=O,Other,11,4,6,992.5299999999994,No,,5J8O,6GZ,32388281,P8,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1194,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=C(C)C(C8=CC=CC=C8)=CC=C7)C=C6OCC9=CC=CC(C#N)=C9)CCCC5)=O)CC4)=O,Active,No,A549; H1299; B16-F10; MDAMB231; Jurkat,7.580600000000011,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,carboxilic_acid_to_amide,11,2,,26.1 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,O=CCCCC(=O)N1CCNCC1,Other,13,4,4,1018.5679999999996,No,,5J8O,6GZ,32388281,P9,No,,Reviewed,Q9NZQ7,No,No,No,No,48,198.75999999999996
+1195,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=C(C)C(C8=CC=CC=C8)=CC=C7)C=C6OCC9=CC=CC(C#N)=C9)CCCC5)=O)CC4)=O,Active,No,A549; H1299; B16-F10; MDAMB231; Jurkat,7.19050000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,carboxilic_acid_to_amide,11,2,,44.5 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,O=CCCC(=O)N1CCNCC1,Other,12,4,3,1004.5409999999996,,,5J8O,6GZ,32388281,P10,No,,Reviewed,Q9NZQ7,No,No,No,No,48,198.75999999999996
+1196,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Inactive,No,,7.329100000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,10,3,,117.6 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,CCN,Alkane,3,1,0,879.4139999999994,No,,5J8O,6GZ,32388281,P11,No,,Reviewed,Q9NZQ7,No,No,No,No,,170.17
+1197,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Inactive,No,,7.71920000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,10,3,,97.3 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,CCCN,Alkane,4,1,1,893.4409999999993,No,,5J8O,6GZ,32388281,P12,No,,Reviewed,Q9NZQ7,No,No,No,No,,170.17
+1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Active,No,A549; H1299; B16-F10; MDAMB231; Jurkat,8.10930000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,8.2 uM,carboxilic_acid_to_amide,10,3,,52.8 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,CCCCN,Alkane,5,1,2,907.4679999999993,No,,5J8O,6GZ,32388281,P13,No,,Reviewed,Q9NZQ7,No,No,No,No,48,170.17
+1199,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCCCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Inactive,No,,8.499400000000009,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,10,3,,170.9 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,CCCCCN,Alkane,6,1,3,921.4949999999992,No,,5J8O,6GZ,32388281,P14,No,,Reviewed,Q9NZQ7,No,No,No,No,,170.17
+1200,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCCCCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O,Inactive,No,,8.889500000000005,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,10,3,,> 200 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,CCCCCCN,Alkane,7,1,4,935.5219999999991,No,,5J8O,6GZ,32388281,P15,No,,Reviewed,Q9NZQ7,No,No,No,No,,170.17
+1201,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)=O)CCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O,Inactive,No,,6.7521000000000075,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,11,4,,98.8 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCNC(=O)CCC=O,Other,10,4,5,978.5029999999995,No,,5J8O,6GZ,32388281,P16,No,,Reviewed,Q9NZQ7,No,No,No,No,,216.33999999999995
+1202,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)NCCNC(COCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)=O,Inactive,No,,5.988500000000005,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,4,,> 200 nM,BMS-1233,O=C(C1N(CC2=CC(Cl)=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OCC5=CC=CC(C#N)=C5)CCCC1)O,NCCNC(=O)COCC=O,Other,11,5,6,994.5019999999993,No,,5J8O,6GZ,32388281,P17,No,,Reviewed,Q9NZQ7,No,No,No,No,,225.56999999999996
+1203,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)=O)CCCC(NC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)=O,Inactive,No,,6.913400000000007,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,> 200 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,NCCNC(=O)CCCC=O,Other,11,4,6,1050.5659999999993,No,,5J8O,6GZ,32388281,P18,No,,Reviewed,Q9NZQ7,No,No,No,No,,234.79999999999998
+1204,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)=O)CCCC(NC7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)=O,Inactive,No,,6.913400000000007,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,> 200 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,NCCNC(=O)CCCC=O,Other,11,4,6,1050.5659999999993,No,,5J8O,6GZ,32388281,P19,No,,Reviewed,Q9NZQ7,No,No,No,No,,234.79999999999998
+1205,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCNC(COCC(NC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)=O)=O,Inactive,No,,5.759700000000004,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,14,4,,> 200 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,NCCNC(=O)COCC=O,Other,11,5,6,1052.5379999999993,No,,5J8O,6GZ,32388281,P20,No,,Reviewed,Q9NZQ7,No,No,No,No,,244.02999999999997
+1206,O=C(NCCNC(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)=O)CCC(NC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O)=O,Inactive,No,,6.523300000000007,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,13,4,,> 200 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,NCCNC(=O)CCC=O,Other,10,4,5,1036.5389999999993,No,,5J8O,6GZ,32388281,P21,No,,Reviewed,Q9NZQ7,No,No,No,No,,234.79999999999998
+1207,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=CC=CC(C8=CC=C9OCCOC9=C8)=C7C)C=C6OCC%10=CC=CC(C#N)=C%10)CCCC5)=O)CC4)=O,Active,Yes,A549; H1299; B16-F10; MDAMB231; Jurkat,7.3518000000000105,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,carboxilic_acid_to_amide,13,2,,39.2 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,O=CCCCC(=O)N1CCNCC1,Other,13,4,4,1076.6039999999996,No,,5J8O,6GZ,32388281,P22,No,,Reviewed,Q9NZQ7,No,No,No,No,48,217.21999999999994
+1208,O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=CC=CC(C8=CC=C9OCCOC9=C8)=C7C)C=C6OCC%10=CC=CC(C#N)=C%10)CCCC5)=O)CC4)=O,Active,No,A549; H1299; B16-F10; MDAMB231; Jurkat,6.96170000000001,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,9.2 uM,carboxilic_acid_to_amide,13,2,,25.2 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,O=CCCC(=O)N1CCNCC1,Other,12,4,3,1062.5769999999998,No,,5J8O,6GZ,32388281,P23,No,,Reviewed,Q9NZQ7,No,No,No,No,48,217.21999999999994
+1209,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O,Inactive,No,,7.100300000000008,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,3,,143.7 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,CCN,Alkane,3,1,0,937.4499999999995,No,,5J8O,6GZ,32388281,P24,No,,Reviewed,Q9NZQ7,No,No,No,No,,188.63
+1210,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O,Inactive,No,,7.490400000000009,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,3,,135.2 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,CCCN,Alkane,4,1,1,951.4769999999994,No,,5J8O,6GZ,32388281,P25,No,,Reviewed,Q9NZQ7,No,No,No,No,,188.63
+1211,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O,Active,No,A549; H1299; B16-F10; MDAMB231; Jurkat,7.880500000000009,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,> 10 uM,carboxilic_acid_to_amide,12,3,,102.7 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,CCCCN,Alkane,5,1,2,965.5039999999993,No,,5J8O,6GZ,32388281,P26,No,,Reviewed,Q9NZQ7,No,No,No,No,48,188.63
+1212,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCCCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O,Inactive,No,,8.270600000000009,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,3,,193.2 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,CCCCCN,Alkane,6,1,3,979.5309999999993,No,,5J8O,6GZ,32388281,P27,No,,Reviewed,Q9NZQ7,No,No,No,No,,188.63
+1213,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)NCCCCCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O,Inactive,No,,8.660700000000007,,Yangwode Jing,,,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,carboxilic_acid_to_amide,12,3,,> 200 nM,BMS-1198,O=C(C1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)CCCC1)O,CCCCCCN,Alkane,7,1,4,993.5579999999992,No,,5J8O,6GZ,32388281,P28,No,,Reviewed,Q9NZQ7,No,No,No,No,,188.63
+1214,O=C1N(C2CCC(NC2=O)=O)C(C3=C(NCCCCCCCC(NC(C=C4)=CC=C4N5CC6=CC=C(O)C=C6OC5=O)=O)C=CC=C31)=O,Active,Yes,A549,4.703600000000003,,Zhangping Xiao,200 nM,90 %,Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O,Cereblon,,,other,9,4,150 nM,108 nM,"3-(3,4-dimethoxyphenyl)-7-hydroxy-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one",OC1=CC=C(CN(C2=CC=C(OC)C(OC)=C2)C(O3)=O)C3=C1,CCCCCCCC(N)=O,Alkane,10,2,6,653.6920000000003,,,,,34018657,MD13,No,,Reviewed,P14174,Yes,Yes,No,Yes,12,174.45
+1215,O=C(N[C@@H](C(C)(C)C)C(N1C[C@@H](C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)CCCC/C=C/C[C@H]([C@H]([C@H]4C(N[C@H](C(N(CC(N([C@H](C(N[C@H](C(N([C@H](C(N[C@H](C(N[C@@H](C(N([C@H](C(N([C@H](C(N([C@H](C(N4C)=O)C(C)C)C)=O)CC(C)C)C)=O)CC(C)C)C)=O)C)=O)C)=O)CC(C)C)C)=O)C(C)C)=O)CC(C)C)C)=O)C)=O)CC)=O)O)C,Active,Yes,Huh7,6.611520000000009,Exhibits potent anti-HCV activity. The first demonstration of a PROTAC antiviral effect by degradation of a host protein (cyclophilin A).,David Selwood,30 nM,90 %,N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl,VHL,188 nM,16 nM,aliphatic_CC,18,8,85 nM,183 nM,cyclosporine A,C/C=C/C[C@H]([C@H]([C@H]1C(N[C@H](C(N(CC(N([C@H](C(N[C@H](C(N([C@H](C(N[C@H](C(N[C@@H](C(N([C@H](C(N([C@H](C(N([C@H](C(N1C)=O)C(C)C)C)=O)CC(C)C)C)=O)CC(C)C)C)=O)C)=O)C)=O)CC(C)C)C)=O)C(C)C)=O)CC(C)C)C)=O)C)=O)CC)=O)O)C,CCCC=O,Alkane,5,1,2,1715.3109999999967,,,1m63,,32539931,JW4-10,No,,Reviewed,P62937,Yes,Yes,No,Yes,"4,8,16,24,48",390.43