
==== Front
Innov Aging
Innov Aging
innovateage
Innovation in Aging
2399-5300 Oxford University Press US 

10.1093/geroni/igz038.3337
igz038.3337
Session Lb2570 (Late Breaking Poster)
Late Breaking Poster Session III
AN ANALYSIS OF C-REACTIVE PROTEIN AND COGNITIVE FUNCTION IN OLDER CHINESE ADULTS
Pan Xi 1 Luo Ye 2 1 
Texas State University, San Marcos, Texas, United States
2 
Clemson University, Clemson, South Carolina, United States
11 2019 
08 11 2019 
08 11 2019 
3 Suppl 1 Program Abstracts from the GSA 2019 Annual Scientific Meeting "Strength in Age—Harnessing the Power of Networks"S915 S915
© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America.2019This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract
Recent evidence suggests that inflammatory markers may reflect cerebral disease mechanisms related to dementia. However, whether and how inflammation is associated with cognitive function in older Chinese is unknown. The current study is to analyze the association between high-sensitivity C-reactive protein (CRP), an indicator of chronic inflammation, and domain-specific cognitive function (i.e., mental status, memory, and overall cognition) among older adults aged 65 years and over in China. Data of the study (n=2,438) were selected from the 2015 China Health and Retirement Longitudinal Study (CHARLS) and were analyzed using linear regression models. Results of the study show that for every 1.00 mg/L increase in CRP, the scores of mental status and overall cognition both decreases by 0.03 unit and higher levels of CRP are observed in men than women. The findings might be useful in interpreting the biological mechanisms of dementia and add value in dementia prevention and health promotion for the general older population.


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