diff --git "a/predict_results_None.txt" "b/predict_results_None.txt" new file mode 100644--- /dev/null +++ "b/predict_results_None.txt" @@ -0,0 +1,29494 @@ +index prediction +0 BACKGROUND +1 BACKGROUND +2 OBJECTIVE +3 METHODS +4 RESULTS +5 METHODS +6 METHODS +7 RESULTS +8 RESULTS +9 RESULTS +10 CONCLUSIONS +11 OBJECTIVE +12 METHODS +13 METHODS +14 RESULTS +15 RESULTS +16 RESULTS +17 CONCLUSIONS +18 OBJECTIVE +19 METHODS +20 RESULTS +21 RESULTS +22 RESULTS +23 RESULTS +24 RESULTS +25 METHODS +26 RESULTS +27 RESULTS +28 RESULTS +29 CONCLUSIONS +30 CONCLUSIONS +31 BACKGROUND +32 BACKGROUND +33 METHODS +34 METHODS +35 METHODS +36 RESULTS +37 RESULTS +38 RESULTS +39 RESULTS +40 RESULTS +41 CONCLUSIONS +42 CONCLUSIONS +43 BACKGROUND +44 OBJECTIVE +45 METHODS +46 METHODS +47 METHODS +48 METHODS +49 RESULTS +50 RESULTS +51 CONCLUSIONS +52 METHODS +53 CONCLUSIONS +54 OBJECTIVE +55 METHODS +56 METHODS +57 METHODS +58 METHODS +59 METHODS +60 METHODS +61 RESULTS +62 RESULTS +63 RESULTS +64 RESULTS +65 RESULTS +66 RESULTS +67 CONCLUSIONS +68 OBJECTIVE +69 METHODS +70 METHODS +71 METHODS +72 RESULTS +73 RESULTS +74 RESULTS +75 CONCLUSIONS +76 BACKGROUND +77 OBJECTIVE +78 METHODS +79 METHODS +80 METHODS +81 METHODS +82 RESULTS +83 RESULTS +84 RESULTS +85 RESULTS +86 RESULTS +87 CONCLUSIONS +88 BACKGROUND +89 BACKGROUND +90 BACKGROUND +91 BACKGROUND +92 METHODS +93 METHODS +94 CONCLUSIONS +95 CONCLUSIONS +96 BACKGROUND +97 OBJECTIVE +98 OBJECTIVE +99 BACKGROUND +100 METHODS +101 METHODS +102 METHODS +103 METHODS +104 METHODS +105 RESULTS +106 RESULTS +107 RESULTS +108 RESULTS +109 CONCLUSIONS +110 CONCLUSIONS +111 BACKGROUND +112 BACKGROUND +113 METHODS +114 METHODS +115 METHODS +116 METHODS +117 RESULTS +118 RESULTS +119 RESULTS +120 RESULTS +121 CONCLUSIONS +122 BACKGROUND +123 BACKGROUND +124 BACKGROUND +125 BACKGROUND +126 BACKGROUND +127 METHODS +128 METHODS +129 BACKGROUND +130 BACKGROUND +131 BACKGROUND +132 BACKGROUND +133 BACKGROUND +134 METHODS +135 METHODS +136 METHODS +137 METHODS +138 METHODS +139 RESULTS +140 RESULTS +141 RESULTS +142 CONCLUSIONS +143 CONCLUSIONS +144 CONCLUSIONS +145 BACKGROUND +146 OBJECTIVE +147 METHODS +148 METHODS +149 RESULTS +150 RESULTS +151 RESULTS +152 RESULTS +153 RESULTS +154 CONCLUSIONS +155 CONCLUSIONS +156 CONCLUSIONS +157 OBJECTIVE +158 METHODS +159 METHODS +160 METHODS +161 METHODS +162 METHODS +163 METHODS +164 METHODS +165 RESULTS +166 RESULTS +167 RESULTS +168 RESULTS +169 RESULTS +170 RESULTS +171 CONCLUSIONS +172 OBJECTIVE +173 METHODS +174 METHODS +175 METHODS +176 METHODS +177 METHODS +178 METHODS +179 METHODS +180 METHODS +181 RESULTS +182 RESULTS +183 CONCLUSIONS +184 CONCLUSIONS +185 OBJECTIVE +186 METHODS +187 METHODS +188 METHODS +189 METHODS +190 RESULTS +191 RESULTS +192 RESULTS +193 RESULTS +194 RESULTS +195 RESULTS +196 CONCLUSIONS +197 CONCLUSIONS +198 BACKGROUND +199 METHODS +200 METHODS +201 METHODS +202 METHODS +203 METHODS +204 RESULTS +205 RESULTS +206 CONCLUSIONS +207 BACKGROUND +208 OBJECTIVE +209 METHODS +210 METHODS +211 METHODS +212 RESULTS +213 RESULTS +214 RESULTS +215 RESULTS +216 RESULTS +217 RESULTS +218 CONCLUSIONS +219 OBJECTIVE +220 METHODS +221 METHODS +222 METHODS +223 RESULTS +224 RESULTS +225 RESULTS +226 RESULTS +227 RESULTS +228 RESULTS +229 RESULTS +230 CONCLUSIONS +231 RESULTS +232 RESULTS +233 CONCLUSIONS +234 BACKGROUND +235 CONCLUSIONS +236 OBJECTIVE +237 METHODS +238 RESULTS +239 RESULTS +240 RESULTS +241 RESULTS +242 RESULTS +243 BACKGROUND +244 CONCLUSIONS +245 CONCLUSIONS +246 BACKGROUND +247 BACKGROUND +248 OBJECTIVE +249 METHODS +250 METHODS +251 METHODS +252 METHODS +253 RESULTS +254 RESULTS +255 RESULTS +256 RESULTS +257 RESULTS +258 RESULTS +259 CONCLUSIONS +260 BACKGROUND +261 CONCLUSIONS +262 METHODS +263 METHODS +264 METHODS +265 METHODS +266 RESULTS +267 RESULTS +268 RESULTS +269 OBJECTIVE +270 OBJECTIVE +271 METHODS +272 METHODS +273 METHODS +274 METHODS +275 METHODS +276 METHODS +277 METHODS +278 METHODS +279 RESULTS +280 RESULTS +281 RESULTS +282 RESULTS +283 RESULTS +284 RESULTS +285 RESULTS +286 CONCLUSIONS +287 CONCLUSIONS +288 RESULTS +289 RESULTS +290 CONCLUSIONS +291 OBJECTIVE +292 OBJECTIVE +293 METHODS +294 METHODS +295 RESULTS +296 CONCLUSIONS +297 RESULTS +298 RESULTS +299 RESULTS +300 RESULTS +301 RESULTS +302 RESULTS +303 CONCLUSIONS +304 CONCLUSIONS +305 OBJECTIVE +306 BACKGROUND +307 BACKGROUND +308 METHODS +309 RESULTS +310 RESULTS +311 RESULTS +312 CONCLUSIONS +313 RESULTS +314 OBJECTIVE +315 METHODS +316 METHODS +317 METHODS +318 RESULTS +319 RESULTS +320 RESULTS +321 RESULTS +322 RESULTS +323 RESULTS +324 CONCLUSIONS +325 BACKGROUND +326 OBJECTIVE +327 BACKGROUND +328 BACKGROUND +329 METHODS +330 RESULTS +331 RESULTS +332 METHODS +333 RESULTS +334 RESULTS +335 CONCLUSIONS +336 CONCLUSIONS +337 CONCLUSIONS +338 OBJECTIVE +339 METHODS +340 METHODS +341 METHODS +342 METHODS +343 METHODS +344 METHODS +345 METHODS +346 RESULTS +347 RESULTS +348 RESULTS +349 CONCLUSIONS +350 CONCLUSIONS +351 BACKGROUND +352 OBJECTIVE +353 METHODS +354 METHODS +355 METHODS +356 RESULTS +357 RESULTS +358 CONCLUSIONS +359 OBJECTIVE +360 METHODS +361 METHODS +362 METHODS +363 METHODS +364 RESULTS +365 RESULTS +366 RESULTS +367 CONCLUSIONS +368 CONCLUSIONS +369 OBJECTIVE +370 METHODS +371 METHODS +372 METHODS +373 METHODS +374 RESULTS +375 RESULTS +376 RESULTS +377 RESULTS +378 CONCLUSIONS +379 RESULTS +380 BACKGROUND +381 BACKGROUND +382 BACKGROUND +383 METHODS +384 METHODS +385 METHODS +386 RESULTS +387 RESULTS +388 CONCLUSIONS +389 CONCLUSIONS +390 BACKGROUND +391 BACKGROUND +392 METHODS +393 METHODS +394 METHODS +395 METHODS +396 METHODS +397 RESULTS +398 RESULTS +399 RESULTS +400 RESULTS +401 RESULTS +402 RESULTS +403 CONCLUSIONS +404 BACKGROUND +405 CONCLUSIONS +406 OBJECTIVE +407 METHODS +408 METHODS +409 RESULTS +410 RESULTS +411 RESULTS +412 RESULTS +413 RESULTS +414 CONCLUSIONS +415 BACKGROUND +416 BACKGROUND +417 METHODS +418 METHODS +419 METHODS +420 METHODS +421 METHODS +422 METHODS +423 METHODS +424 METHODS +425 RESULTS +426 RESULTS +427 RESULTS +428 RESULTS +429 RESULTS +430 CONCLUSIONS +431 CONCLUSIONS +432 OBJECTIVE +433 METHODS +434 METHODS +435 METHODS +436 RESULTS +437 RESULTS +438 RESULTS +439 RESULTS +440 RESULTS +441 CONCLUSIONS +442 OBJECTIVE +443 OBJECTIVE +444 BACKGROUND +445 BACKGROUND +446 OBJECTIVE +447 RESULTS +448 RESULTS +449 RESULTS +450 METHODS +451 METHODS +452 METHODS +453 METHODS +454 METHODS +455 RESULTS +456 RESULTS +457 RESULTS +458 RESULTS +459 CONCLUSIONS +460 RESULTS +461 CONCLUSIONS +462 BACKGROUND +463 BACKGROUND +464 METHODS +465 METHODS +466 RESULTS +467 RESULTS +468 RESULTS +469 RESULTS +470 CONCLUSIONS +471 CONCLUSIONS +472 OBJECTIVE +473 BACKGROUND +474 METHODS +475 METHODS +476 METHODS +477 RESULTS +478 METHODS +479 RESULTS +480 RESULTS +481 RESULTS +482 RESULTS +483 RESULTS +484 RESULTS +485 CONCLUSIONS +486 OBJECTIVE +487 METHODS +488 METHODS +489 METHODS +490 METHODS +491 METHODS +492 METHODS +493 METHODS +494 RESULTS +495 RESULTS +496 RESULTS +497 CONCLUSIONS +498 OBJECTIVE +499 METHODS +500 METHODS +501 METHODS +502 METHODS +503 METHODS +504 METHODS +505 RESULTS +506 RESULTS +507 RESULTS +508 RESULTS +509 CONCLUSIONS +510 BACKGROUND +511 BACKGROUND +512 CONCLUSIONS +513 OBJECTIVE +514 METHODS +515 METHODS +516 METHODS +517 RESULTS +518 RESULTS +519 RESULTS +520 RESULTS +521 RESULTS +522 RESULTS +523 CONCLUSIONS +524 CONCLUSIONS +525 BACKGROUND +526 OBJECTIVE +527 OBJECTIVE +528 METHODS +529 METHODS +530 METHODS +531 METHODS +532 METHODS +533 METHODS +534 METHODS +535 RESULTS +536 RESULTS +537 CONCLUSIONS +538 OBJECTIVE +539 OBJECTIVE +540 RESULTS +541 RESULTS +542 RESULTS +543 RESULTS +544 RESULTS +545 OBJECTIVE +546 OBJECTIVE +547 METHODS +548 METHODS +549 RESULTS +550 RESULTS +551 RESULTS +552 CONCLUSIONS +553 OBJECTIVE +554 METHODS +555 METHODS +556 METHODS +557 METHODS +558 METHODS +559 METHODS +560 METHODS +561 METHODS +562 RESULTS +563 RESULTS +564 RESULTS +565 CONCLUSIONS +566 OBJECTIVE +567 METHODS +568 METHODS +569 METHODS +570 METHODS +571 RESULTS +572 RESULTS +573 RESULTS +574 RESULTS +575 CONCLUSIONS +576 RESULTS +577 RESULTS +578 RESULTS +579 CONCLUSIONS +580 BACKGROUND +581 BACKGROUND +582 METHODS +583 METHODS +584 RESULTS +585 RESULTS +586 RESULTS +587 RESULTS +588 RESULTS +589 RESULTS +590 RESULTS +591 RESULTS +592 RESULTS +593 CONCLUSIONS +594 CONCLUSIONS +595 BACKGROUND +596 BACKGROUND +597 BACKGROUND +598 BACKGROUND +599 CONCLUSIONS +600 CONCLUSIONS +601 METHODS +602 METHODS +603 METHODS +604 METHODS +605 METHODS +606 METHODS +607 BACKGROUND +608 BACKGROUND +609 BACKGROUND +610 OBJECTIVE +611 METHODS +612 METHODS +613 RESULTS +614 RESULTS +615 RESULTS +616 CONCLUSIONS +617 CONCLUSIONS +618 OBJECTIVE +619 METHODS +620 METHODS +621 METHODS +622 METHODS +623 METHODS +624 RESULTS +625 RESULTS +626 RESULTS +627 RESULTS +628 RESULTS +629 CONCLUSIONS +630 BACKGROUND +631 BACKGROUND +632 METHODS +633 METHODS +634 METHODS +635 CONCLUSIONS +636 METHODS +637 METHODS +638 METHODS +639 METHODS +640 CONCLUSIONS +641 BACKGROUND +642 BACKGROUND +643 OBJECTIVE +644 METHODS +645 METHODS +646 METHODS +647 RESULTS +648 RESULTS +649 CONCLUSIONS +650 CONCLUSIONS +651 CONCLUSIONS +652 OBJECTIVE +653 METHODS +654 METHODS +655 METHODS +656 RESULTS +657 RESULTS +658 RESULTS +659 RESULTS +660 CONCLUSIONS +661 RESULTS +662 RESULTS +663 OBJECTIVE +664 OBJECTIVE +665 METHODS +666 RESULTS +667 RESULTS +668 CONCLUSIONS +669 OBJECTIVE +670 METHODS +671 METHODS +672 METHODS +673 METHODS +674 METHODS +675 RESULTS +676 RESULTS +677 RESULTS +678 CONCLUSIONS +679 BACKGROUND +680 OBJECTIVE +681 METHODS +682 METHODS +683 METHODS +684 METHODS +685 METHODS +686 RESULTS +687 RESULTS +688 RESULTS +689 RESULTS +690 RESULTS +691 CONCLUSIONS +692 BACKGROUND +693 BACKGROUND +694 METHODS +695 METHODS +696 METHODS +697 RESULTS +698 RESULTS +699 RESULTS +700 RESULTS +701 CONCLUSIONS +702 RESULTS +703 OBJECTIVE +704 METHODS +705 RESULTS +706 RESULTS +707 RESULTS +708 CONCLUSIONS +709 CONCLUSIONS +710 OBJECTIVE +711 METHODS +712 METHODS +713 METHODS +714 METHODS +715 METHODS +716 METHODS +717 RESULTS +718 RESULTS +719 RESULTS +720 RESULTS +721 RESULTS +722 CONCLUSIONS +723 RESULTS +724 METHODS +725 OBJECTIVE +726 METHODS +727 METHODS +728 METHODS +729 METHODS +730 METHODS +731 METHODS +732 RESULTS +733 RESULTS +734 CONCLUSIONS +735 BACKGROUND +736 BACKGROUND +737 BACKGROUND +738 METHODS +739 METHODS +740 METHODS +741 CONCLUSIONS +742 RESULTS +743 CONCLUSIONS +744 CONCLUSIONS +745 CONCLUSIONS +746 BACKGROUND +747 OBJECTIVE +748 METHODS +749 METHODS +750 RESULTS +751 RESULTS +752 CONCLUSIONS +753 OBJECTIVE +754 METHODS +755 METHODS +756 METHODS +757 METHODS +758 METHODS +759 CONCLUSIONS +760 RESULTS +761 BACKGROUND +762 METHODS +763 METHODS +764 METHODS +765 RESULTS +766 RESULTS +767 RESULTS +768 CONCLUSIONS +769 BACKGROUND +770 BACKGROUND +771 BACKGROUND +772 BACKGROUND +773 OBJECTIVE +774 METHODS +775 METHODS +776 METHODS +777 METHODS +778 METHODS +779 RESULTS +780 RESULTS +781 RESULTS +782 CONCLUSIONS +783 CONCLUSIONS +784 CONCLUSIONS +785 CONCLUSIONS +786 BACKGROUND +787 BACKGROUND +788 METHODS +789 METHODS +790 METHODS +791 METHODS +792 METHODS +793 METHODS +794 METHODS +795 RESULTS +796 RESULTS +797 RESULTS +798 RESULTS +799 CONCLUSIONS +800 CONCLUSIONS +801 OBJECTIVE +802 METHODS +803 RESULTS +804 RESULTS +805 RESULTS +806 RESULTS +807 RESULTS +808 RESULTS +809 CONCLUSIONS +810 OBJECTIVE +811 METHODS +812 METHODS +813 METHODS +814 METHODS +815 METHODS +816 METHODS +817 METHODS +818 RESULTS +819 RESULTS +820 RESULTS +821 RESULTS +822 CONCLUSIONS +823 BACKGROUND +824 BACKGROUND +825 METHODS +826 METHODS +827 METHODS +828 METHODS +829 METHODS +830 RESULTS +831 RESULTS +832 RESULTS +833 RESULTS +834 CONCLUSIONS +835 CONCLUSIONS +836 BACKGROUND +837 OBJECTIVE +838 OBJECTIVE +839 METHODS +840 METHODS +841 METHODS +842 METHODS +843 RESULTS +844 RESULTS +845 RESULTS +846 RESULTS +847 RESULTS +848 RESULTS +849 CONCLUSIONS +850 CONCLUSIONS +851 BACKGROUND +852 BACKGROUND +853 BACKGROUND +854 METHODS +855 METHODS +856 METHODS +857 RESULTS +858 RESULTS +859 RESULTS +860 CONCLUSIONS +861 RESULTS +862 BACKGROUND +863 CONCLUSIONS +864 BACKGROUND +865 BACKGROUND +866 BACKGROUND +867 METHODS +868 METHODS +869 METHODS +870 RESULTS +871 RESULTS +872 RESULTS +873 RESULTS +874 RESULTS +875 CONCLUSIONS +876 CONCLUSIONS +877 BACKGROUND +878 CONCLUSIONS +879 OBJECTIVE +880 BACKGROUND +881 METHODS +882 METHODS +883 METHODS +884 RESULTS +885 RESULTS +886 RESULTS +887 RESULTS +888 RESULTS +889 CONCLUSIONS +890 CONCLUSIONS +891 CONCLUSIONS +892 OBJECTIVE +893 METHODS +894 METHODS +895 METHODS +896 METHODS +897 METHODS +898 RESULTS +899 RESULTS +900 RESULTS +901 RESULTS +902 RESULTS +903 RESULTS +904 CONCLUSIONS +905 BACKGROUND +906 METHODS +907 METHODS +908 METHODS +909 METHODS +910 RESULTS +911 RESULTS +912 RESULTS +913 RESULTS +914 CONCLUSIONS +915 RESULTS +916 BACKGROUND +917 BACKGROUND +918 BACKGROUND +919 METHODS +920 METHODS +921 METHODS +922 METHODS +923 RESULTS +924 RESULTS +925 RESULTS +926 CONCLUSIONS +927 CONCLUSIONS +928 BACKGROUND +929 OBJECTIVE +930 METHODS +931 METHODS +932 METHODS +933 METHODS +934 METHODS +935 METHODS +936 METHODS +937 METHODS +938 RESULTS +939 RESULTS +940 RESULTS +941 CONCLUSIONS +942 BACKGROUND +943 BACKGROUND +944 OBJECTIVE +945 METHODS +946 METHODS +947 METHODS +948 METHODS +949 RESULTS +950 RESULTS +951 RESULTS +952 RESULTS +953 RESULTS +954 RESULTS +955 CONCLUSIONS +956 CONCLUSIONS +957 OBJECTIVE +958 METHODS +959 METHODS +960 METHODS +961 RESULTS +962 RESULTS +963 RESULTS +964 RESULTS +965 RESULTS +966 CONCLUSIONS +967 BACKGROUND +968 OBJECTIVE +969 METHODS +970 METHODS +971 RESULTS +972 RESULTS +973 RESULTS +974 CONCLUSIONS +975 CONCLUSIONS +976 CONCLUSIONS +977 OBJECTIVE +978 METHODS +979 METHODS +980 METHODS +981 RESULTS +982 RESULTS +983 RESULTS +984 CONCLUSIONS +985 BACKGROUND +986 CONCLUSIONS +987 OBJECTIVE +988 RESULTS +989 RESULTS +990 RESULTS +991 RESULTS +992 CONCLUSIONS +993 CONCLUSIONS +994 BACKGROUND +995 BACKGROUND +996 BACKGROUND +997 METHODS +998 METHODS +999 METHODS +1000 RESULTS +1001 RESULTS +1002 RESULTS +1003 RESULTS +1004 CONCLUSIONS +1005 CONCLUSIONS +1006 BACKGROUND +1007 BACKGROUND +1008 BACKGROUND +1009 OBJECTIVE +1010 METHODS +1011 METHODS +1012 METHODS +1013 METHODS +1014 RESULTS +1015 RESULTS +1016 RESULTS +1017 RESULTS +1018 CONCLUSIONS +1019 CONCLUSIONS +1020 OBJECTIVE +1021 METHODS +1022 METHODS +1023 METHODS +1024 RESULTS +1025 RESULTS +1026 CONCLUSIONS +1027 OBJECTIVE +1028 METHODS +1029 METHODS +1030 RESULTS +1031 RESULTS +1032 METHODS +1033 METHODS +1034 METHODS +1035 METHODS +1036 RESULTS +1037 RESULTS +1038 CONCLUSIONS +1039 BACKGROUND +1040 BACKGROUND +1041 BACKGROUND +1042 BACKGROUND +1043 METHODS +1044 RESULTS +1045 RESULTS +1046 RESULTS +1047 RESULTS +1048 CONCLUSIONS +1049 CONCLUSIONS +1050 OBJECTIVE +1051 METHODS +1052 METHODS +1053 METHODS +1054 RESULTS +1055 RESULTS +1056 RESULTS +1057 CONCLUSIONS +1058 BACKGROUND +1059 OBJECTIVE +1060 METHODS +1061 METHODS +1062 METHODS +1063 METHODS +1064 METHODS +1065 METHODS +1066 METHODS +1067 METHODS +1068 METHODS +1069 METHODS +1070 RESULTS +1071 RESULTS +1072 RESULTS +1073 RESULTS +1074 CONCLUSIONS +1075 RESULTS +1076 BACKGROUND +1077 OBJECTIVE +1078 METHODS +1079 METHODS +1080 METHODS +1081 RESULTS +1082 RESULTS +1083 RESULTS +1084 RESULTS +1085 CONCLUSIONS +1086 BACKGROUND +1087 BACKGROUND +1088 BACKGROUND +1089 METHODS +1090 METHODS +1091 METHODS +1092 METHODS +1093 RESULTS +1094 RESULTS +1095 CONCLUSIONS +1096 RESULTS +1097 OBJECTIVE +1098 METHODS +1099 METHODS +1100 METHODS +1101 RESULTS +1102 RESULTS +1103 RESULTS +1104 RESULTS +1105 RESULTS +1106 CONCLUSIONS +1107 RESULTS +1108 CONCLUSIONS +1109 OBJECTIVE +1110 METHODS +1111 RESULTS +1112 RESULTS +1113 RESULTS +1114 CONCLUSIONS +1115 CONCLUSIONS +1116 CONCLUSIONS +1117 METHODS +1118 METHODS +1119 METHODS +1120 METHODS +1121 RESULTS +1122 RESULTS +1123 RESULTS +1124 RESULTS +1125 RESULTS +1126 RESULTS +1127 RESULTS +1128 CONCLUSIONS +1129 RESULTS +1130 OBJECTIVE +1131 METHODS +1132 RESULTS +1133 METHODS +1134 METHODS +1135 METHODS +1136 METHODS +1137 RESULTS +1138 RESULTS +1139 RESULTS +1140 RESULTS +1141 RESULTS +1142 RESULTS +1143 CONCLUSIONS +1144 OBJECTIVE +1145 METHODS +1146 METHODS +1147 METHODS +1148 METHODS +1149 METHODS +1150 METHODS +1151 RESULTS +1152 RESULTS +1153 RESULTS +1154 RESULTS +1155 RESULTS +1156 RESULTS +1157 CONCLUSIONS +1158 CONCLUSIONS +1159 CONCLUSIONS +1160 BACKGROUND +1161 OBJECTIVE +1162 METHODS +1163 METHODS +1164 METHODS +1165 RESULTS +1166 RESULTS +1167 RESULTS +1168 CONCLUSIONS +1169 CONCLUSIONS +1170 BACKGROUND +1171 OBJECTIVE +1172 METHODS +1173 RESULTS +1174 RESULTS +1175 RESULTS +1176 RESULTS +1177 RESULTS +1178 RESULTS +1179 CONCLUSIONS +1180 OBJECTIVE +1181 METHODS +1182 METHODS +1183 RESULTS +1184 RESULTS +1185 RESULTS +1186 RESULTS +1187 CONCLUSIONS +1188 CONCLUSIONS +1189 BACKGROUND +1190 BACKGROUND +1191 METHODS +1192 METHODS +1193 METHODS +1194 METHODS +1195 RESULTS +1196 RESULTS +1197 RESULTS +1198 RESULTS +1199 RESULTS +1200 RESULTS +1201 RESULTS +1202 RESULTS +1203 RESULTS +1204 RESULTS +1205 RESULTS +1206 CONCLUSIONS +1207 OBJECTIVE +1208 METHODS +1209 METHODS +1210 RESULTS +1211 RESULTS +1212 RESULTS +1213 RESULTS +1214 RESULTS +1215 RESULTS +1216 RESULTS +1217 RESULTS +1218 CONCLUSIONS +1219 BACKGROUND +1220 CONCLUSIONS +1221 METHODS +1222 METHODS +1223 BACKGROUND +1224 METHODS +1225 METHODS +1226 RESULTS +1227 RESULTS +1228 RESULTS +1229 RESULTS +1230 RESULTS +1231 RESULTS +1232 CONCLUSIONS +1233 RESULTS +1234 BACKGROUND +1235 BACKGROUND +1236 BACKGROUND +1237 METHODS +1238 METHODS +1239 METHODS +1240 METHODS +1241 METHODS +1242 RESULTS +1243 RESULTS +1244 RESULTS +1245 CONCLUSIONS +1246 BACKGROUND +1247 BACKGROUND +1248 METHODS +1249 METHODS +1250 METHODS +1251 RESULTS +1252 RESULTS +1253 RESULTS +1254 RESULTS +1255 RESULTS +1256 BACKGROUND +1257 OBJECTIVE +1258 OBJECTIVE +1259 METHODS +1260 METHODS +1261 METHODS +1262 METHODS +1263 METHODS +1264 RESULTS +1265 RESULTS +1266 RESULTS +1267 RESULTS +1268 RESULTS +1269 RESULTS +1270 BACKGROUND +1271 OBJECTIVE +1272 BACKGROUND +1273 OBJECTIVE +1274 METHODS +1275 METHODS +1276 METHODS +1277 RESULTS +1278 RESULTS +1279 RESULTS +1280 RESULTS +1281 RESULTS +1282 CONCLUSIONS +1283 CONCLUSIONS +1284 CONCLUSIONS +1285 BACKGROUND +1286 CONCLUSIONS +1287 OBJECTIVE +1288 METHODS +1289 METHODS +1290 RESULTS +1291 RESULTS +1292 RESULTS +1293 RESULTS +1294 CONCLUSIONS +1295 CONCLUSIONS +1296 CONCLUSIONS +1297 BACKGROUND +1298 BACKGROUND +1299 OBJECTIVE +1300 METHODS +1301 METHODS +1302 METHODS +1303 RESULTS +1304 RESULTS +1305 RESULTS +1306 RESULTS +1307 RESULTS +1308 CONCLUSIONS +1309 BACKGROUND +1310 OBJECTIVE +1311 BACKGROUND +1312 BACKGROUND +1313 METHODS +1314 METHODS +1315 RESULTS +1316 RESULTS +1317 RESULTS +1318 RESULTS +1319 RESULTS +1320 METHODS +1321 METHODS +1322 RESULTS +1323 BACKGROUND +1324 BACKGROUND +1325 BACKGROUND +1326 CONCLUSIONS +1327 BACKGROUND +1328 METHODS +1329 METHODS +1330 METHODS +1331 METHODS +1332 METHODS +1333 METHODS +1334 CONCLUSIONS +1335 CONCLUSIONS +1336 BACKGROUND +1337 OBJECTIVE +1338 METHODS +1339 METHODS +1340 METHODS +1341 METHODS +1342 METHODS +1343 RESULTS +1344 RESULTS +1345 RESULTS +1346 RESULTS +1347 CONCLUSIONS +1348 OBJECTIVE +1349 METHODS +1350 METHODS +1351 METHODS +1352 METHODS +1353 METHODS +1354 RESULTS +1355 BACKGROUND +1356 BACKGROUND +1357 BACKGROUND +1358 METHODS +1359 METHODS +1360 METHODS +1361 RESULTS +1362 RESULTS +1363 RESULTS +1364 RESULTS +1365 RESULTS +1366 RESULTS +1367 RESULTS +1368 RESULTS +1369 CONCLUSIONS +1370 BACKGROUND +1371 BACKGROUND +1372 BACKGROUND +1373 METHODS +1374 RESULTS +1375 RESULTS +1376 RESULTS +1377 RESULTS +1378 RESULTS +1379 CONCLUSIONS +1380 BACKGROUND +1381 OBJECTIVE +1382 METHODS +1383 METHODS +1384 METHODS +1385 METHODS +1386 METHODS +1387 METHODS +1388 METHODS +1389 RESULTS +1390 RESULTS +1391 RESULTS +1392 RESULTS +1393 RESULTS +1394 RESULTS +1395 RESULTS +1396 RESULTS +1397 RESULTS +1398 RESULTS +1399 RESULTS +1400 RESULTS +1401 CONCLUSIONS +1402 OBJECTIVE +1403 OBJECTIVE +1404 METHODS +1405 METHODS +1406 METHODS +1407 METHODS +1408 RESULTS +1409 RESULTS +1410 RESULTS +1411 CONCLUSIONS +1412 BACKGROUND +1413 BACKGROUND +1414 OBJECTIVE +1415 METHODS +1416 METHODS +1417 METHODS +1418 RESULTS +1419 CONCLUSIONS +1420 OBJECTIVE +1421 METHODS +1422 METHODS +1423 METHODS +1424 RESULTS +1425 RESULTS +1426 CONCLUSIONS +1427 OBJECTIVE +1428 BACKGROUND +1429 BACKGROUND +1430 BACKGROUND +1431 METHODS +1432 METHODS +1433 METHODS +1434 METHODS +1435 METHODS +1436 RESULTS +1437 RESULTS +1438 RESULTS +1439 RESULTS +1440 CONCLUSIONS +1441 BACKGROUND +1442 OBJECTIVE +1443 METHODS +1444 METHODS +1445 METHODS +1446 RESULTS +1447 RESULTS +1448 RESULTS +1449 CONCLUSIONS +1450 CONCLUSIONS +1451 OBJECTIVE +1452 METHODS +1453 METHODS +1454 METHODS +1455 METHODS +1456 METHODS +1457 METHODS +1458 RESULTS +1459 RESULTS +1460 RESULTS +1461 RESULTS +1462 CONCLUSIONS +1463 RESULTS +1464 CONCLUSIONS +1465 CONCLUSIONS +1466 CONCLUSIONS +1467 OBJECTIVE +1468 METHODS +1469 METHODS +1470 METHODS +1471 RESULTS +1472 METHODS +1473 RESULTS +1474 RESULTS +1475 RESULTS +1476 RESULTS +1477 RESULTS +1478 CONCLUSIONS +1479 OBJECTIVE +1480 METHODS +1481 METHODS +1482 METHODS +1483 METHODS +1484 METHODS +1485 RESULTS +1486 RESULTS +1487 RESULTS +1488 RESULTS +1489 RESULTS +1490 RESULTS +1491 RESULTS +1492 CONCLUSIONS +1493 OBJECTIVE +1494 METHODS +1495 METHODS +1496 METHODS +1497 METHODS +1498 METHODS +1499 METHODS +1500 METHODS +1501 RESULTS +1502 RESULTS +1503 CONCLUSIONS +1504 BACKGROUND +1505 CONCLUSIONS +1506 BACKGROUND +1507 BACKGROUND +1508 METHODS +1509 METHODS +1510 METHODS +1511 METHODS +1512 METHODS +1513 METHODS +1514 METHODS +1515 RESULTS +1516 RESULTS +1517 RESULTS +1518 RESULTS +1519 RESULTS +1520 RESULTS +1521 CONCLUSIONS +1522 BACKGROUND +1523 BACKGROUND +1524 METHODS +1525 METHODS +1526 METHODS +1527 METHODS +1528 RESULTS +1529 RESULTS +1530 RESULTS +1531 CONCLUSIONS +1532 BACKGROUND +1533 CONCLUSIONS +1534 OBJECTIVE +1535 METHODS +1536 METHODS +1537 METHODS +1538 RESULTS +1539 RESULTS +1540 RESULTS +1541 RESULTS +1542 RESULTS +1543 CONCLUSIONS +1544 OBJECTIVE +1545 METHODS +1546 RESULTS +1547 RESULTS +1548 CONCLUSIONS +1549 BACKGROUND +1550 OBJECTIVE +1551 RESULTS +1552 METHODS +1553 METHODS +1554 METHODS +1555 METHODS +1556 RESULTS +1557 RESULTS +1558 RESULTS +1559 RESULTS +1560 RESULTS +1561 RESULTS +1562 RESULTS +1563 RESULTS +1564 CONCLUSIONS +1565 RESULTS +1566 CONCLUSIONS +1567 BACKGROUND +1568 BACKGROUND +1569 METHODS +1570 RESULTS +1571 RESULTS +1572 CONCLUSIONS +1573 BACKGROUND +1574 BACKGROUND +1575 OBJECTIVE +1576 METHODS +1577 METHODS +1578 METHODS +1579 METHODS +1580 RESULTS +1581 RESULTS +1582 CONCLUSIONS +1583 CONCLUSIONS +1584 BACKGROUND +1585 BACKGROUND +1586 BACKGROUND +1587 BACKGROUND +1588 BACKGROUND +1589 METHODS +1590 METHODS +1591 METHODS +1592 METHODS +1593 RESULTS +1594 RESULTS +1595 RESULTS +1596 CONCLUSIONS +1597 CONCLUSIONS +1598 OBJECTIVE +1599 METHODS +1600 METHODS +1601 METHODS +1602 METHODS +1603 METHODS +1604 RESULTS +1605 RESULTS +1606 CONCLUSIONS +1607 BACKGROUND +1608 BACKGROUND +1609 OBJECTIVE +1610 METHODS +1611 RESULTS +1612 RESULTS +1613 RESULTS +1614 RESULTS +1615 RESULTS +1616 RESULTS +1617 CONCLUSIONS +1618 RESULTS +1619 CONCLUSIONS +1620 OBJECTIVE +1621 METHODS +1622 METHODS +1623 METHODS +1624 METHODS +1625 METHODS +1626 METHODS +1627 METHODS +1628 RESULTS +1629 RESULTS +1630 RESULTS +1631 RESULTS +1632 RESULTS +1633 RESULTS +1634 BACKGROUND +1635 CONCLUSIONS +1636 OBJECTIVE +1637 METHODS +1638 METHODS +1639 METHODS +1640 METHODS +1641 RESULTS +1642 RESULTS +1643 RESULTS +1644 RESULTS +1645 CONCLUSIONS +1646 OBJECTIVE +1647 METHODS +1648 RESULTS +1649 RESULTS +1650 CONCLUSIONS +1651 CONCLUSIONS +1652 OBJECTIVE +1653 METHODS +1654 METHODS +1655 METHODS +1656 RESULTS +1657 RESULTS +1658 CONCLUSIONS +1659 OBJECTIVE +1660 METHODS +1661 METHODS +1662 METHODS +1663 METHODS +1664 METHODS +1665 RESULTS +1666 METHODS +1667 METHODS +1668 RESULTS +1669 RESULTS +1670 RESULTS +1671 CONCLUSIONS +1672 RESULTS +1673 CONCLUSIONS +1674 BACKGROUND +1675 BACKGROUND +1676 CONCLUSIONS +1677 METHODS +1678 METHODS +1679 METHODS +1680 METHODS +1681 METHODS +1682 RESULTS +1683 RESULTS +1684 METHODS +1685 RESULTS +1686 RESULTS +1687 RESULTS +1688 RESULTS +1689 CONCLUSIONS +1690 OBJECTIVE +1691 OBJECTIVE +1692 BACKGROUND +1693 METHODS +1694 METHODS +1695 METHODS +1696 RESULTS +1697 RESULTS +1698 RESULTS +1699 CONCLUSIONS +1700 CONCLUSIONS +1701 BACKGROUND +1702 OBJECTIVE +1703 METHODS +1704 METHODS +1705 RESULTS +1706 METHODS +1707 METHODS +1708 RESULTS +1709 RESULTS +1710 CONCLUSIONS +1711 BACKGROUND +1712 BACKGROUND +1713 OBJECTIVE +1714 METHODS +1715 METHODS +1716 METHODS +1717 METHODS +1718 RESULTS +1719 RESULTS +1720 RESULTS +1721 RESULTS +1722 RESULTS +1723 CONCLUSIONS +1724 BACKGROUND +1725 BACKGROUND +1726 BACKGROUND +1727 BACKGROUND +1728 METHODS +1729 BACKGROUND +1730 METHODS +1731 METHODS +1732 METHODS +1733 METHODS +1734 METHODS +1735 METHODS +1736 RESULTS +1737 RESULTS +1738 RESULTS +1739 RESULTS +1740 RESULTS +1741 RESULTS +1742 RESULTS +1743 RESULTS +1744 CONCLUSIONS +1745 OBJECTIVE +1746 METHODS +1747 METHODS +1748 METHODS +1749 METHODS +1750 METHODS +1751 RESULTS +1752 CONCLUSIONS +1753 BACKGROUND +1754 BACKGROUND +1755 OBJECTIVE +1756 METHODS +1757 METHODS +1758 RESULTS +1759 RESULTS +1760 RESULTS +1761 CONCLUSIONS +1762 OBJECTIVE +1763 METHODS +1764 METHODS +1765 METHODS +1766 RESULTS +1767 RESULTS +1768 RESULTS +1769 RESULTS +1770 CONCLUSIONS +1771 BACKGROUND +1772 BACKGROUND +1773 RESULTS +1774 METHODS +1775 RESULTS +1776 METHODS +1777 RESULTS +1778 RESULTS +1779 RESULTS +1780 CONCLUSIONS +1781 RESULTS +1782 CONCLUSIONS +1783 BACKGROUND +1784 BACKGROUND +1785 OBJECTIVE +1786 METHODS +1787 METHODS +1788 METHODS +1789 RESULTS +1790 RESULTS +1791 CONCLUSIONS +1792 CONCLUSIONS +1793 CONCLUSIONS +1794 OBJECTIVE +1795 BACKGROUND +1796 METHODS +1797 METHODS +1798 RESULTS +1799 RESULTS +1800 RESULTS +1801 RESULTS +1802 RESULTS +1803 BACKGROUND +1804 CONCLUSIONS +1805 BACKGROUND +1806 BACKGROUND +1807 BACKGROUND +1808 BACKGROUND +1809 METHODS +1810 METHODS +1811 METHODS +1812 METHODS +1813 METHODS +1814 METHODS +1815 METHODS +1816 CONCLUSIONS +1817 BACKGROUND +1818 BACKGROUND +1819 METHODS +1820 METHODS +1821 BACKGROUND +1822 CONCLUSIONS +1823 CONCLUSIONS +1824 CONCLUSIONS +1825 CONCLUSIONS +1826 BACKGROUND +1827 OBJECTIVE +1828 METHODS +1829 METHODS +1830 RESULTS +1831 RESULTS +1832 RESULTS +1833 RESULTS +1834 RESULTS +1835 CONCLUSIONS +1836 OBJECTIVE +1837 METHODS +1838 METHODS +1839 METHODS +1840 METHODS +1841 METHODS +1842 RESULTS +1843 METHODS +1844 METHODS +1845 RESULTS +1846 RESULTS +1847 CONCLUSIONS +1848 OBJECTIVE +1849 METHODS +1850 METHODS +1851 METHODS +1852 METHODS +1853 RESULTS +1854 RESULTS +1855 RESULTS +1856 RESULTS +1857 CONCLUSIONS +1858 CONCLUSIONS +1859 BACKGROUND +1860 BACKGROUND +1861 METHODS +1862 METHODS +1863 METHODS +1864 METHODS +1865 RESULTS +1866 RESULTS +1867 CONCLUSIONS +1868 CONCLUSIONS +1869 BACKGROUND +1870 OBJECTIVE +1871 METHODS +1872 RESULTS +1873 RESULTS +1874 RESULTS +1875 RESULTS +1876 RESULTS +1877 RESULTS +1878 CONCLUSIONS +1879 RESULTS +1880 CONCLUSIONS +1881 CONCLUSIONS +1882 METHODS +1883 METHODS +1884 METHODS +1885 RESULTS +1886 RESULTS +1887 CONCLUSIONS +1888 BACKGROUND +1889 OBJECTIVE +1890 RESULTS +1891 RESULTS +1892 RESULTS +1893 RESULTS +1894 RESULTS +1895 CONCLUSIONS +1896 CONCLUSIONS +1897 OBJECTIVE +1898 OBJECTIVE +1899 METHODS +1900 METHODS +1901 RESULTS +1902 RESULTS +1903 RESULTS +1904 RESULTS +1905 RESULTS +1906 RESULTS +1907 RESULTS +1908 CONCLUSIONS +1909 OBJECTIVE +1910 METHODS +1911 METHODS +1912 RESULTS +1913 RESULTS +1914 RESULTS +1915 RESULTS +1916 RESULTS +1917 CONCLUSIONS +1918 RESULTS +1919 RESULTS +1920 CONCLUSIONS +1921 BACKGROUND +1922 METHODS +1923 METHODS +1924 METHODS +1925 RESULTS +1926 RESULTS +1927 RESULTS +1928 CONCLUSIONS +1929 BACKGROUND +1930 BACKGROUND +1931 OBJECTIVE +1932 METHODS +1933 METHODS +1934 RESULTS +1935 RESULTS +1936 RESULTS +1937 RESULTS +1938 RESULTS +1939 CONCLUSIONS +1940 OBJECTIVE +1941 METHODS +1942 METHODS +1943 RESULTS +1944 RESULTS +1945 RESULTS +1946 RESULTS +1947 RESULTS +1948 CONCLUSIONS +1949 RESULTS +1950 OBJECTIVE +1951 OBJECTIVE +1952 OBJECTIVE +1953 METHODS +1954 METHODS +1955 RESULTS +1956 RESULTS +1957 RESULTS +1958 RESULTS +1959 OBJECTIVE +1960 CONCLUSIONS +1961 CONCLUSIONS +1962 CONCLUSIONS +1963 BACKGROUND +1964 BACKGROUND +1965 METHODS +1966 METHODS +1967 RESULTS +1968 RESULTS +1969 RESULTS +1970 RESULTS +1971 CONCLUSIONS +1972 CONCLUSIONS +1973 BACKGROUND +1974 METHODS +1975 METHODS +1976 METHODS +1977 RESULTS +1978 METHODS +1979 METHODS +1980 METHODS +1981 METHODS +1982 METHODS +1983 RESULTS +1984 RESULTS +1985 RESULTS +1986 RESULTS +1987 RESULTS +1988 CONCLUSIONS +1989 RESULTS +1990 BACKGROUND +1991 OBJECTIVE +1992 METHODS +1993 METHODS +1994 METHODS +1995 RESULTS +1996 RESULTS +1997 CONCLUSIONS +1998 CONCLUSIONS +1999 CONCLUSIONS +2000 OBJECTIVE +2001 METHODS +2002 METHODS +2003 METHODS +2004 METHODS +2005 METHODS +2006 RESULTS +2007 RESULTS +2008 RESULTS +2009 CONCLUSIONS +2010 BACKGROUND +2011 METHODS +2012 METHODS +2013 METHODS +2014 METHODS +2015 METHODS +2016 METHODS +2017 METHODS +2018 RESULTS +2019 RESULTS +2020 RESULTS +2021 CONCLUSIONS +2022 CONCLUSIONS +2023 BACKGROUND +2024 BACKGROUND +2025 METHODS +2026 METHODS +2027 RESULTS +2028 CONCLUSIONS +2029 CONCLUSIONS +2030 OBJECTIVE +2031 METHODS +2032 METHODS +2033 RESULTS +2034 RESULTS +2035 RESULTS +2036 RESULTS +2037 RESULTS +2038 RESULTS +2039 CONCLUSIONS +2040 OBJECTIVE +2041 METHODS +2042 METHODS +2043 RESULTS +2044 RESULTS +2045 CONCLUSIONS +2046 BACKGROUND +2047 OBJECTIVE +2048 METHODS +2049 METHODS +2050 METHODS +2051 RESULTS +2052 RESULTS +2053 CONCLUSIONS +2054 BACKGROUND +2055 BACKGROUND +2056 METHODS +2057 METHODS +2058 METHODS +2059 METHODS +2060 RESULTS +2061 RESULTS +2062 RESULTS +2063 RESULTS +2064 CONCLUSIONS +2065 CONCLUSIONS +2066 BACKGROUND +2067 BACKGROUND +2068 BACKGROUND +2069 METHODS +2070 BACKGROUND +2071 METHODS +2072 METHODS +2073 METHODS +2074 METHODS +2075 METHODS +2076 METHODS +2077 METHODS +2078 CONCLUSIONS +2079 CONCLUSIONS +2080 BACKGROUND +2081 OBJECTIVE +2082 METHODS +2083 METHODS +2084 METHODS +2085 METHODS +2086 METHODS +2087 METHODS +2088 METHODS +2089 METHODS +2090 RESULTS +2091 RESULTS +2092 RESULTS +2093 RESULTS +2094 RESULTS +2095 CONCLUSIONS +2096 CONCLUSIONS +2097 CONCLUSIONS +2098 CONCLUSIONS +2099 METHODS +2100 METHODS +2101 RESULTS +2102 RESULTS +2103 RESULTS +2104 RESULTS +2105 RESULTS +2106 RESULTS +2107 CONCLUSIONS +2108 CONCLUSIONS +2109 RESULTS +2110 CONCLUSIONS +2111 CONCLUSIONS +2112 OBJECTIVE +2113 BACKGROUND +2114 CONCLUSIONS +2115 METHODS +2116 METHODS +2117 METHODS +2118 METHODS +2119 RESULTS +2120 RESULTS +2121 RESULTS +2122 CONCLUSIONS +2123 BACKGROUND +2124 BACKGROUND +2125 BACKGROUND +2126 BACKGROUND +2127 BACKGROUND +2128 BACKGROUND +2129 METHODS +2130 METHODS +2131 METHODS +2132 METHODS +2133 RESULTS +2134 RESULTS +2135 RESULTS +2136 CONCLUSIONS +2137 OBJECTIVE +2138 METHODS +2139 METHODS +2140 METHODS +2141 METHODS +2142 RESULTS +2143 RESULTS +2144 RESULTS +2145 RESULTS +2146 RESULTS +2147 RESULTS +2148 CONCLUSIONS +2149 METHODS +2150 METHODS +2151 METHODS +2152 METHODS +2153 METHODS +2154 METHODS +2155 METHODS +2156 METHODS +2157 METHODS +2158 METHODS +2159 RESULTS +2160 RESULTS +2161 RESULTS +2162 CONCLUSIONS +2163 CONCLUSIONS +2164 BACKGROUND +2165 METHODS +2166 METHODS +2167 METHODS +2168 RESULTS +2169 RESULTS +2170 BACKGROUND +2171 CONCLUSIONS +2172 CONCLUSIONS +2173 OBJECTIVE +2174 METHODS +2175 RESULTS +2176 METHODS +2177 RESULTS +2178 CONCLUSIONS +2179 RESULTS +2180 RESULTS +2181 RESULTS +2182 CONCLUSIONS +2183 OBJECTIVE +2184 METHODS +2185 METHODS +2186 METHODS +2187 METHODS +2188 METHODS +2189 RESULTS +2190 CONCLUSIONS +2191 RESULTS +2192 RESULTS +2193 CONCLUSIONS +2194 OBJECTIVE +2195 METHODS +2196 METHODS +2197 RESULTS +2198 RESULTS +2199 RESULTS +2200 RESULTS +2201 CONCLUSIONS +2202 BACKGROUND +2203 BACKGROUND +2204 OBJECTIVE +2205 METHODS +2206 METHODS +2207 METHODS +2208 RESULTS +2209 RESULTS +2210 RESULTS +2211 CONCLUSIONS +2212 BACKGROUND +2213 BACKGROUND +2214 BACKGROUND +2215 OBJECTIVE +2216 METHODS +2217 METHODS +2218 METHODS +2219 METHODS +2220 METHODS +2221 RESULTS +2222 RESULTS +2223 RESULTS +2224 CONCLUSIONS +2225 BACKGROUND +2226 OBJECTIVE +2227 METHODS +2228 METHODS +2229 RESULTS +2230 RESULTS +2231 RESULTS +2232 RESULTS +2233 CONCLUSIONS +2234 BACKGROUND +2235 OBJECTIVE +2236 METHODS +2237 METHODS +2238 METHODS +2239 METHODS +2240 RESULTS +2241 CONCLUSIONS +2242 OBJECTIVE +2243 METHODS +2244 METHODS +2245 METHODS +2246 METHODS +2247 METHODS +2248 RESULTS +2249 RESULTS +2250 RESULTS +2251 RESULTS +2252 CONCLUSIONS +2253 BACKGROUND +2254 METHODS +2255 METHODS +2256 METHODS +2257 METHODS +2258 RESULTS +2259 METHODS +2260 METHODS +2261 RESULTS +2262 RESULTS +2263 RESULTS +2264 RESULTS +2265 RESULTS +2266 RESULTS +2267 CONCLUSIONS +2268 BACKGROUND +2269 OBJECTIVE +2270 METHODS +2271 METHODS +2272 RESULTS +2273 RESULTS +2274 RESULTS +2275 RESULTS +2276 RESULTS +2277 RESULTS +2278 RESULTS +2279 RESULTS +2280 RESULTS +2281 RESULTS +2282 RESULTS +2283 RESULTS +2284 OBJECTIVE +2285 METHODS +2286 METHODS +2287 METHODS +2288 RESULTS +2289 RESULTS +2290 CONCLUSIONS +2291 OBJECTIVE +2292 METHODS +2293 METHODS +2294 METHODS +2295 METHODS +2296 METHODS +2297 METHODS +2298 RESULTS +2299 RESULTS +2300 RESULTS +2301 RESULTS +2302 RESULTS +2303 CONCLUSIONS +2304 METHODS +2305 BACKGROUND +2306 OBJECTIVE +2307 OBJECTIVE +2308 METHODS +2309 METHODS +2310 RESULTS +2311 RESULTS +2312 CONCLUSIONS +2313 CONCLUSIONS +2314 BACKGROUND +2315 BACKGROUND +2316 METHODS +2317 METHODS +2318 METHODS +2319 METHODS +2320 METHODS +2321 RESULTS +2322 RESULTS +2323 RESULTS +2324 RESULTS +2325 CONCLUSIONS +2326 BACKGROUND +2327 OBJECTIVE +2328 OBJECTIVE +2329 METHODS +2330 METHODS +2331 METHODS +2332 METHODS +2333 RESULTS +2334 RESULTS +2335 RESULTS +2336 CONCLUSIONS +2337 CONCLUSIONS +2338 BACKGROUND +2339 CONCLUSIONS +2340 CONCLUSIONS +2341 CONCLUSIONS +2342 OBJECTIVE +2343 BACKGROUND +2344 METHODS +2345 METHODS +2346 METHODS +2347 CONCLUSIONS +2348 RESULTS +2349 RESULTS +2350 RESULTS +2351 CONCLUSIONS +2352 CONCLUSIONS +2353 BACKGROUND +2354 BACKGROUND +2355 BACKGROUND +2356 OBJECTIVE +2357 METHODS +2358 METHODS +2359 METHODS +2360 METHODS +2361 METHODS +2362 RESULTS +2363 RESULTS +2364 RESULTS +2365 RESULTS +2366 CONCLUSIONS +2367 BACKGROUND +2368 BACKGROUND +2369 METHODS +2370 METHODS +2371 METHODS +2372 METHODS +2373 RESULTS +2374 RESULTS +2375 RESULTS +2376 RESULTS +2377 RESULTS +2378 CONCLUSIONS +2379 BACKGROUND +2380 CONCLUSIONS +2381 OBJECTIVE +2382 METHODS +2383 METHODS +2384 RESULTS +2385 RESULTS +2386 RESULTS +2387 CONCLUSIONS +2388 BACKGROUND +2389 BACKGROUND +2390 METHODS +2391 RESULTS +2392 RESULTS +2393 RESULTS +2394 RESULTS +2395 RESULTS +2396 RESULTS +2397 CONCLUSIONS +2398 CONCLUSIONS +2399 CONCLUSIONS +2400 OBJECTIVE +2401 METHODS +2402 METHODS +2403 METHODS +2404 METHODS +2405 METHODS +2406 METHODS +2407 METHODS +2408 METHODS +2409 RESULTS +2410 RESULTS +2411 RESULTS +2412 RESULTS +2413 CONCLUSIONS +2414 BACKGROUND +2415 CONCLUSIONS +2416 OBJECTIVE +2417 OBJECTIVE +2418 METHODS +2419 METHODS +2420 METHODS +2421 METHODS +2422 RESULTS +2423 RESULTS +2424 RESULTS +2425 CONCLUSIONS +2426 CONCLUSIONS +2427 BACKGROUND +2428 METHODS +2429 METHODS +2430 METHODS +2431 METHODS +2432 RESULTS +2433 RESULTS +2434 RESULTS +2435 RESULTS +2436 RESULTS +2437 RESULTS +2438 RESULTS +2439 RESULTS +2440 CONCLUSIONS +2441 BACKGROUND +2442 CONCLUSIONS +2443 METHODS +2444 METHODS +2445 METHODS +2446 RESULTS +2447 RESULTS +2448 CONCLUSIONS +2449 CONCLUSIONS +2450 CONCLUSIONS +2451 OBJECTIVE +2452 METHODS +2453 METHODS +2454 RESULTS +2455 RESULTS +2456 RESULTS +2457 RESULTS +2458 RESULTS +2459 METHODS +2460 RESULTS +2461 RESULTS +2462 RESULTS +2463 OBJECTIVE +2464 METHODS +2465 METHODS +2466 METHODS +2467 METHODS +2468 METHODS +2469 RESULTS +2470 CONCLUSIONS +2471 OBJECTIVE +2472 METHODS +2473 METHODS +2474 METHODS +2475 METHODS +2476 METHODS +2477 RESULTS +2478 RESULTS +2479 CONCLUSIONS +2480 OBJECTIVE +2481 METHODS +2482 METHODS +2483 METHODS +2484 METHODS +2485 RESULTS +2486 RESULTS +2487 RESULTS +2488 RESULTS +2489 CONCLUSIONS +2490 OBJECTIVE +2491 METHODS +2492 METHODS +2493 RESULTS +2494 METHODS +2495 METHODS +2496 METHODS +2497 RESULTS +2498 RESULTS +2499 RESULTS +2500 RESULTS +2501 RESULTS +2502 RESULTS +2503 RESULTS +2504 CONCLUSIONS +2505 OBJECTIVE +2506 METHODS +2507 METHODS +2508 METHODS +2509 METHODS +2510 RESULTS +2511 RESULTS +2512 RESULTS +2513 RESULTS +2514 RESULTS +2515 RESULTS +2516 RESULTS +2517 RESULTS +2518 RESULTS +2519 CONCLUSIONS +2520 BACKGROUND +2521 METHODS +2522 BACKGROUND +2523 RESULTS +2524 RESULTS +2525 BACKGROUND +2526 RESULTS +2527 RESULTS +2528 CONCLUSIONS +2529 CONCLUSIONS +2530 OBJECTIVE +2531 METHODS +2532 METHODS +2533 METHODS +2534 METHODS +2535 METHODS +2536 METHODS +2537 METHODS +2538 RESULTS +2539 RESULTS +2540 RESULTS +2541 RESULTS +2542 RESULTS +2543 RESULTS +2544 CONCLUSIONS +2545 RESULTS +2546 BACKGROUND +2547 BACKGROUND +2548 OBJECTIVE +2549 METHODS +2550 METHODS +2551 RESULTS +2552 RESULTS +2553 RESULTS +2554 RESULTS +2555 RESULTS +2556 CONCLUSIONS +2557 CONCLUSIONS +2558 BACKGROUND +2559 OBJECTIVE +2560 METHODS +2561 METHODS +2562 METHODS +2563 METHODS +2564 METHODS +2565 RESULTS +2566 RESULTS +2567 RESULTS +2568 RESULTS +2569 RESULTS +2570 RESULTS +2571 RESULTS +2572 CONCLUSIONS +2573 OBJECTIVE +2574 METHODS +2575 METHODS +2576 METHODS +2577 METHODS +2578 METHODS +2579 RESULTS +2580 RESULTS +2581 RESULTS +2582 CONCLUSIONS +2583 OBJECTIVE +2584 METHODS +2585 METHODS +2586 METHODS +2587 METHODS +2588 METHODS +2589 METHODS +2590 RESULTS +2591 RESULTS +2592 RESULTS +2593 RESULTS +2594 CONCLUSIONS +2595 CONCLUSIONS +2596 CONCLUSIONS +2597 OBJECTIVE +2598 METHODS +2599 RESULTS +2600 RESULTS +2601 RESULTS +2602 RESULTS +2603 CONCLUSIONS +2604 CONCLUSIONS +2605 OBJECTIVE +2606 METHODS +2607 METHODS +2608 METHODS +2609 METHODS +2610 RESULTS +2611 RESULTS +2612 RESULTS +2613 RESULTS +2614 CONCLUSIONS +2615 CONCLUSIONS +2616 BACKGROUND +2617 OBJECTIVE +2618 METHODS +2619 METHODS +2620 METHODS +2621 RESULTS +2622 RESULTS +2623 CONCLUSIONS +2624 BACKGROUND +2625 CONCLUSIONS +2626 OBJECTIVE +2627 CONCLUSIONS +2628 METHODS +2629 METHODS +2630 METHODS +2631 RESULTS +2632 RESULTS +2633 RESULTS +2634 RESULTS +2635 CONCLUSIONS +2636 CONCLUSIONS +2637 BACKGROUND +2638 OBJECTIVE +2639 METHODS +2640 RESULTS +2641 METHODS +2642 METHODS +2643 RESULTS +2644 CONCLUSIONS +2645 CONCLUSIONS +2646 OBJECTIVE +2647 METHODS +2648 METHODS +2649 METHODS +2650 METHODS +2651 METHODS +2652 RESULTS +2653 RESULTS +2654 RESULTS +2655 RESULTS +2656 RESULTS +2657 RESULTS +2658 CONCLUSIONS +2659 RESULTS +2660 CONCLUSIONS +2661 OBJECTIVE +2662 METHODS +2663 METHODS +2664 METHODS +2665 RESULTS +2666 RESULTS +2667 RESULTS +2668 RESULTS +2669 RESULTS +2670 RESULTS +2671 CONCLUSIONS +2672 CONCLUSIONS +2673 CONCLUSIONS +2674 BACKGROUND +2675 OBJECTIVE +2676 METHODS +2677 METHODS +2678 RESULTS +2679 RESULTS +2680 RESULTS +2681 RESULTS +2682 CONCLUSIONS +2683 CONCLUSIONS +2684 RESULTS +2685 OBJECTIVE +2686 METHODS +2687 METHODS +2688 METHODS +2689 METHODS +2690 RESULTS +2691 RESULTS +2692 RESULTS +2693 RESULTS +2694 RESULTS +2695 CONCLUSIONS +2696 CONCLUSIONS +2697 BACKGROUND +2698 METHODS +2699 RESULTS +2700 BACKGROUND +2701 RESULTS +2702 RESULTS +2703 RESULTS +2704 CONCLUSIONS +2705 BACKGROUND +2706 BACKGROUND +2707 METHODS +2708 RESULTS +2709 RESULTS +2710 RESULTS +2711 RESULTS +2712 CONCLUSIONS +2713 OBJECTIVE +2714 OBJECTIVE +2715 METHODS +2716 METHODS +2717 RESULTS +2718 RESULTS +2719 RESULTS +2720 RESULTS +2721 CONCLUSIONS +2722 CONCLUSIONS +2723 CONCLUSIONS +2724 OBJECTIVE +2725 METHODS +2726 METHODS +2727 METHODS +2728 METHODS +2729 METHODS +2730 RESULTS +2731 RESULTS +2732 RESULTS +2733 RESULTS +2734 RESULTS +2735 CONCLUSIONS +2736 BACKGROUND +2737 METHODS +2738 METHODS +2739 METHODS +2740 METHODS +2741 METHODS +2742 RESULTS +2743 RESULTS +2744 RESULTS +2745 RESULTS +2746 CONCLUSIONS +2747 BACKGROUND +2748 BACKGROUND +2749 METHODS +2750 METHODS +2751 METHODS +2752 METHODS +2753 METHODS +2754 METHODS +2755 METHODS +2756 RESULTS +2757 RESULTS +2758 CONCLUSIONS +2759 OBJECTIVE +2760 METHODS +2761 METHODS +2762 METHODS +2763 METHODS +2764 METHODS +2765 METHODS +2766 METHODS +2767 METHODS +2768 METHODS +2769 METHODS +2770 RESULTS +2771 RESULTS +2772 RESULTS +2773 RESULTS +2774 RESULTS +2775 CONCLUSIONS +2776 CONCLUSIONS +2777 BACKGROUND +2778 METHODS +2779 METHODS +2780 METHODS +2781 METHODS +2782 METHODS +2783 METHODS +2784 METHODS +2785 OBJECTIVE +2786 RESULTS +2787 RESULTS +2788 RESULTS +2789 RESULTS +2790 RESULTS +2791 RESULTS +2792 CONCLUSIONS +2793 CONCLUSIONS +2794 BACKGROUND +2795 OBJECTIVE +2796 OBJECTIVE +2797 METHODS +2798 METHODS +2799 METHODS +2800 METHODS +2801 RESULTS +2802 RESULTS +2803 RESULTS +2804 CONCLUSIONS +2805 CONCLUSIONS +2806 CONCLUSIONS +2807 CONCLUSIONS +2808 BACKGROUND +2809 BACKGROUND +2810 OBJECTIVE +2811 METHODS +2812 METHODS +2813 RESULTS +2814 RESULTS +2815 RESULTS +2816 RESULTS +2817 BACKGROUND +2818 BACKGROUND +2819 RESULTS +2820 METHODS +2821 RESULTS +2822 RESULTS +2823 RESULTS +2824 CONCLUSIONS +2825 BACKGROUND +2826 BACKGROUND +2827 BACKGROUND +2828 OBJECTIVE +2829 METHODS +2830 METHODS +2831 METHODS +2832 RESULTS +2833 RESULTS +2834 RESULTS +2835 RESULTS +2836 RESULTS +2837 RESULTS +2838 CONCLUSIONS +2839 CONCLUSIONS +2840 OBJECTIVE +2841 METHODS +2842 METHODS +2843 METHODS +2844 METHODS +2845 METHODS +2846 METHODS +2847 METHODS +2848 METHODS +2849 RESULTS +2850 RESULTS +2851 RESULTS +2852 OBJECTIVE +2853 METHODS +2854 METHODS +2855 METHODS +2856 METHODS +2857 RESULTS +2858 RESULTS +2859 RESULTS +2860 RESULTS +2861 OBJECTIVE +2862 METHODS +2863 METHODS +2864 METHODS +2865 METHODS +2866 METHODS +2867 METHODS +2868 METHODS +2869 RESULTS +2870 RESULTS +2871 RESULTS +2872 CONCLUSIONS +2873 OBJECTIVE +2874 METHODS +2875 METHODS +2876 METHODS +2877 METHODS +2878 METHODS +2879 METHODS +2880 RESULTS +2881 RESULTS +2882 CONCLUSIONS +2883 BACKGROUND +2884 METHODS +2885 METHODS +2886 METHODS +2887 METHODS +2888 RESULTS +2889 RESULTS +2890 RESULTS +2891 RESULTS +2892 RESULTS +2893 RESULTS +2894 CONCLUSIONS +2895 CONCLUSIONS +2896 OBJECTIVE +2897 METHODS +2898 METHODS +2899 METHODS +2900 METHODS +2901 METHODS +2902 METHODS +2903 RESULTS +2904 RESULTS +2905 RESULTS +2906 RESULTS +2907 RESULTS +2908 RESULTS +2909 CONCLUSIONS +2910 BACKGROUND +2911 METHODS +2912 OBJECTIVE +2913 METHODS +2914 METHODS +2915 METHODS +2916 METHODS +2917 METHODS +2918 RESULTS +2919 RESULTS +2920 RESULTS +2921 OBJECTIVE +2922 METHODS +2923 METHODS +2924 METHODS +2925 RESULTS +2926 RESULTS +2927 RESULTS +2928 RESULTS +2929 CONCLUSIONS +2930 CONCLUSIONS +2931 OBJECTIVE +2932 METHODS +2933 METHODS +2934 METHODS +2935 METHODS +2936 METHODS +2937 METHODS +2938 METHODS +2939 RESULTS +2940 RESULTS +2941 RESULTS +2942 RESULTS +2943 CONCLUSIONS +2944 CONCLUSIONS +2945 RESULTS +2946 CONCLUSIONS +2947 BACKGROUND +2948 CONCLUSIONS +2949 BACKGROUND +2950 METHODS +2951 METHODS +2952 METHODS +2953 METHODS +2954 RESULTS +2955 RESULTS +2956 CONCLUSIONS +2957 BACKGROUND +2958 BACKGROUND +2959 OBJECTIVE +2960 METHODS +2961 METHODS +2962 METHODS +2963 METHODS +2964 RESULTS +2965 RESULTS +2966 RESULTS +2967 RESULTS +2968 RESULTS +2969 RESULTS +2970 RESULTS +2971 RESULTS +2972 RESULTS +2973 CONCLUSIONS +2974 BACKGROUND +2975 BACKGROUND +2976 METHODS +2977 METHODS +2978 METHODS +2979 METHODS +2980 RESULTS +2981 RESULTS +2982 RESULTS +2983 RESULTS +2984 RESULTS +2985 CONCLUSIONS +2986 CONCLUSIONS +2987 OBJECTIVE +2988 METHODS +2989 METHODS +2990 METHODS +2991 RESULTS +2992 RESULTS +2993 RESULTS +2994 RESULTS +2995 RESULTS +2996 RESULTS +2997 CONCLUSIONS +2998 CONCLUSIONS +2999 OBJECTIVE +3000 METHODS +3001 RESULTS +3002 RESULTS +3003 RESULTS +3004 RESULTS +3005 CONCLUSIONS +3006 CONCLUSIONS +3007 BACKGROUND +3008 BACKGROUND +3009 OBJECTIVE +3010 METHODS +3011 METHODS +3012 METHODS +3013 RESULTS +3014 RESULTS +3015 RESULTS +3016 RESULTS +3017 RESULTS +3018 RESULTS +3019 RESULTS +3020 RESULTS +3021 CONCLUSIONS +3022 CONCLUSIONS +3023 OBJECTIVE +3024 METHODS +3025 METHODS +3026 RESULTS +3027 RESULTS +3028 RESULTS +3029 RESULTS +3030 RESULTS +3031 RESULTS +3032 BACKGROUND +3033 BACKGROUND +3034 OBJECTIVE +3035 METHODS +3036 METHODS +3037 METHODS +3038 RESULTS +3039 RESULTS +3040 RESULTS +3041 CONCLUSIONS +3042 CONCLUSIONS +3043 CONCLUSIONS +3044 OBJECTIVE +3045 METHODS +3046 METHODS +3047 METHODS +3048 METHODS +3049 METHODS +3050 METHODS +3051 METHODS +3052 METHODS +3053 RESULTS +3054 RESULTS +3055 RESULTS +3056 CONCLUSIONS +3057 OBJECTIVE +3058 METHODS +3059 METHODS +3060 METHODS +3061 METHODS +3062 METHODS +3063 RESULTS +3064 RESULTS +3065 CONCLUSIONS +3066 CONCLUSIONS +3067 BACKGROUND +3068 BACKGROUND +3069 OBJECTIVE +3070 METHODS +3071 METHODS +3072 METHODS +3073 RESULTS +3074 RESULTS +3075 RESULTS +3076 RESULTS +3077 RESULTS +3078 RESULTS +3079 CONCLUSIONS +3080 OBJECTIVE +3081 BACKGROUND +3082 METHODS +3083 METHODS +3084 METHODS +3085 METHODS +3086 METHODS +3087 RESULTS +3088 CONCLUSIONS +3089 OBJECTIVE +3090 RESULTS +3091 METHODS +3092 RESULTS +3093 RESULTS +3094 RESULTS +3095 RESULTS +3096 CONCLUSIONS +3097 OBJECTIVE +3098 METHODS +3099 METHODS +3100 METHODS +3101 METHODS +3102 METHODS +3103 RESULTS +3104 RESULTS +3105 RESULTS +3106 RESULTS +3107 CONCLUSIONS +3108 BACKGROUND +3109 OBJECTIVE +3110 OBJECTIVE +3111 OBJECTIVE +3112 METHODS +3113 METHODS +3114 RESULTS +3115 RESULTS +3116 RESULTS +3117 CONCLUSIONS +3118 CONCLUSIONS +3119 OBJECTIVE +3120 METHODS +3121 METHODS +3122 METHODS +3123 RESULTS +3124 RESULTS +3125 CONCLUSIONS +3126 CONCLUSIONS +3127 OBJECTIVE +3128 METHODS +3129 METHODS +3130 METHODS +3131 METHODS +3132 RESULTS +3133 RESULTS +3134 RESULTS +3135 RESULTS +3136 RESULTS +3137 RESULTS +3138 RESULTS +3139 RESULTS +3140 RESULTS +3141 RESULTS +3142 RESULTS +3143 RESULTS +3144 RESULTS +3145 RESULTS +3146 BACKGROUND +3147 BACKGROUND +3148 METHODS +3149 METHODS +3150 METHODS +3151 METHODS +3152 METHODS +3153 METHODS +3154 RESULTS +3155 RESULTS +3156 RESULTS +3157 CONCLUSIONS +3158 BACKGROUND +3159 BACKGROUND +3160 RESULTS +3161 METHODS +3162 RESULTS +3163 RESULTS +3164 RESULTS +3165 CONCLUSIONS +3166 CONCLUSIONS +3167 BACKGROUND +3168 BACKGROUND +3169 BACKGROUND +3170 BACKGROUND +3171 METHODS +3172 OBJECTIVE +3173 METHODS +3174 METHODS +3175 METHODS +3176 METHODS +3177 METHODS +3178 RESULTS +3179 RESULTS +3180 RESULTS +3181 RESULTS +3182 RESULTS +3183 RESULTS +3184 RESULTS +3185 CONCLUSIONS +3186 CONCLUSIONS +3187 CONCLUSIONS +3188 BACKGROUND +3189 OBJECTIVE +3190 METHODS +3191 METHODS +3192 METHODS +3193 RESULTS +3194 RESULTS +3195 RESULTS +3196 RESULTS +3197 RESULTS +3198 RESULTS +3199 RESULTS +3200 CONCLUSIONS +3201 BACKGROUND +3202 BACKGROUND +3203 METHODS +3204 METHODS +3205 METHODS +3206 METHODS +3207 METHODS +3208 RESULTS +3209 RESULTS +3210 CONCLUSIONS +3211 BACKGROUND +3212 BACKGROUND +3213 OBJECTIVE +3214 METHODS +3215 METHODS +3216 RESULTS +3217 METHODS +3218 METHODS +3219 RESULTS +3220 RESULTS +3221 RESULTS +3222 CONCLUSIONS +3223 BACKGROUND +3224 BACKGROUND +3225 BACKGROUND +3226 METHODS +3227 METHODS +3228 METHODS +3229 RESULTS +3230 RESULTS +3231 RESULTS +3232 CONCLUSIONS +3233 OBJECTIVE +3234 METHODS +3235 METHODS +3236 METHODS +3237 METHODS +3238 METHODS +3239 RESULTS +3240 RESULTS +3241 RESULTS +3242 RESULTS +3243 METHODS +3244 RESULTS +3245 BACKGROUND +3246 RESULTS +3247 CONCLUSIONS +3248 OBJECTIVE +3249 METHODS +3250 METHODS +3251 METHODS +3252 METHODS +3253 RESULTS +3254 RESULTS +3255 RESULTS +3256 RESULTS +3257 RESULTS +3258 CONCLUSIONS +3259 CONCLUSIONS +3260 BACKGROUND +3261 OBJECTIVE +3262 OBJECTIVE +3263 METHODS +3264 METHODS +3265 METHODS +3266 METHODS +3267 METHODS +3268 METHODS +3269 METHODS +3270 RESULTS +3271 METHODS +3272 RESULTS +3273 RESULTS +3274 RESULTS +3275 RESULTS +3276 RESULTS +3277 RESULTS +3278 METHODS +3279 RESULTS +3280 RESULTS +3281 CONCLUSIONS +3282 CONCLUSIONS +3283 OBJECTIVE +3284 METHODS +3285 METHODS +3286 METHODS +3287 RESULTS +3288 RESULTS +3289 RESULTS +3290 RESULTS +3291 RESULTS +3292 CONCLUSIONS +3293 OBJECTIVE +3294 BACKGROUND +3295 OBJECTIVE +3296 METHODS +3297 METHODS +3298 METHODS +3299 METHODS +3300 METHODS +3301 METHODS +3302 METHODS +3303 METHODS +3304 RESULTS +3305 RESULTS +3306 RESULTS +3307 RESULTS +3308 RESULTS +3309 RESULTS +3310 CONCLUSIONS +3311 RESULTS +3312 BACKGROUND +3313 BACKGROUND +3314 OBJECTIVE +3315 METHODS +3316 METHODS +3317 RESULTS +3318 RESULTS +3319 RESULTS +3320 RESULTS +3321 RESULTS +3322 RESULTS +3323 CONCLUSIONS +3324 BACKGROUND +3325 BACKGROUND +3326 METHODS +3327 METHODS +3328 METHODS +3329 METHODS +3330 METHODS +3331 METHODS +3332 METHODS +3333 RESULTS +3334 RESULTS +3335 RESULTS +3336 RESULTS +3337 RESULTS +3338 CONCLUSIONS +3339 CONCLUSIONS +3340 BACKGROUND +3341 BACKGROUND +3342 BACKGROUND +3343 METHODS +3344 METHODS +3345 METHODS +3346 RESULTS +3347 CONCLUSIONS +3348 CONCLUSIONS +3349 OBJECTIVE +3350 METHODS +3351 METHODS +3352 METHODS +3353 METHODS +3354 RESULTS +3355 RESULTS +3356 CONCLUSIONS +3357 RESULTS +3358 RESULTS +3359 RESULTS +3360 RESULTS +3361 CONCLUSIONS +3362 BACKGROUND +3363 OBJECTIVE +3364 METHODS +3365 METHODS +3366 RESULTS +3367 RESULTS +3368 CONCLUSIONS +3369 OBJECTIVE +3370 METHODS +3371 METHODS +3372 METHODS +3373 RESULTS +3374 METHODS +3375 METHODS +3376 RESULTS +3377 METHODS +3378 RESULTS +3379 CONCLUSIONS +3380 CONCLUSIONS +3381 BACKGROUND +3382 BACKGROUND +3383 CONCLUSIONS +3384 OBJECTIVE +3385 METHODS +3386 METHODS +3387 RESULTS +3388 RESULTS +3389 CONCLUSIONS +3390 CONCLUSIONS +3391 CONCLUSIONS +3392 OBJECTIVE +3393 METHODS +3394 METHODS +3395 METHODS +3396 METHODS +3397 RESULTS +3398 CONCLUSIONS +3399 BACKGROUND +3400 BACKGROUND +3401 BACKGROUND +3402 BACKGROUND +3403 METHODS +3404 METHODS +3405 METHODS +3406 RESULTS +3407 RESULTS +3408 RESULTS +3409 RESULTS +3410 RESULTS +3411 RESULTS +3412 CONCLUSIONS +3413 CONCLUSIONS +3414 OBJECTIVE +3415 METHODS +3416 METHODS +3417 METHODS +3418 CONCLUSIONS +3419 CONCLUSIONS +3420 CONCLUSIONS +3421 BACKGROUND +3422 BACKGROUND +3423 METHODS +3424 METHODS +3425 RESULTS +3426 RESULTS +3427 RESULTS +3428 RESULTS +3429 RESULTS +3430 CONCLUSIONS +3431 CONCLUSIONS +3432 CONCLUSIONS +3433 BACKGROUND +3434 CONCLUSIONS +3435 OBJECTIVE +3436 METHODS +3437 METHODS +3438 METHODS +3439 METHODS +3440 RESULTS +3441 CONCLUSIONS +3442 CONCLUSIONS +3443 CONCLUSIONS +3444 BACKGROUND +3445 BACKGROUND +3446 BACKGROUND +3447 METHODS +3448 METHODS +3449 METHODS +3450 METHODS +3451 METHODS +3452 RESULTS +3453 RESULTS +3454 RESULTS +3455 RESULTS +3456 CONCLUSIONS +3457 BACKGROUND +3458 BACKGROUND +3459 BACKGROUND +3460 METHODS +3461 METHODS +3462 METHODS +3463 RESULTS +3464 RESULTS +3465 CONCLUSIONS +3466 RESULTS +3467 BACKGROUND +3468 BACKGROUND +3469 CONCLUSIONS +3470 OBJECTIVE +3471 METHODS +3472 METHODS +3473 METHODS +3474 METHODS +3475 METHODS +3476 RESULTS +3477 RESULTS +3478 RESULTS +3479 RESULTS +3480 RESULTS +3481 CONCLUSIONS +3482 CONCLUSIONS +3483 BACKGROUND +3484 BACKGROUND +3485 METHODS +3486 METHODS +3487 METHODS +3488 METHODS +3489 METHODS +3490 OBJECTIVE +3491 METHODS +3492 METHODS +3493 METHODS +3494 METHODS +3495 METHODS +3496 METHODS +3497 METHODS +3498 METHODS +3499 METHODS +3500 RESULTS +3501 RESULTS +3502 RESULTS +3503 METHODS +3504 METHODS +3505 CONCLUSIONS +3506 RESULTS +3507 METHODS +3508 METHODS +3509 RESULTS +3510 RESULTS +3511 CONCLUSIONS +3512 OBJECTIVE +3513 METHODS +3514 METHODS +3515 METHODS +3516 METHODS +3517 METHODS +3518 METHODS +3519 METHODS +3520 RESULTS +3521 RESULTS +3522 RESULTS +3523 RESULTS +3524 RESULTS +3525 CONCLUSIONS +3526 OBJECTIVE +3527 METHODS +3528 METHODS +3529 METHODS +3530 METHODS +3531 METHODS +3532 METHODS +3533 METHODS +3534 METHODS +3535 METHODS +3536 METHODS +3537 RESULTS +3538 RESULTS +3539 RESULTS +3540 RESULTS +3541 CONCLUSIONS +3542 OBJECTIVE +3543 METHODS +3544 METHODS +3545 RESULTS +3546 RESULTS +3547 CONCLUSIONS +3548 CONCLUSIONS +3549 BACKGROUND +3550 CONCLUSIONS +3551 BACKGROUND +3552 METHODS +3553 CONCLUSIONS +3554 RESULTS +3555 BACKGROUND +3556 METHODS +3557 METHODS +3558 RESULTS +3559 RESULTS +3560 RESULTS +3561 RESULTS +3562 METHODS +3563 CONCLUSIONS +3564 CONCLUSIONS +3565 OBJECTIVE +3566 METHODS +3567 METHODS +3568 METHODS +3569 METHODS +3570 METHODS +3571 RESULTS +3572 RESULTS +3573 RESULTS +3574 RESULTS +3575 CONCLUSIONS +3576 OBJECTIVE +3577 OBJECTIVE +3578 METHODS +3579 RESULTS +3580 RESULTS +3581 CONCLUSIONS +3582 BACKGROUND +3583 BACKGROUND +3584 METHODS +3585 METHODS +3586 METHODS +3587 RESULTS +3588 RESULTS +3589 RESULTS +3590 RESULTS +3591 CONCLUSIONS +3592 CONCLUSIONS +3593 BACKGROUND +3594 BACKGROUND +3595 CONCLUSIONS +3596 BACKGROUND +3597 OBJECTIVE +3598 METHODS +3599 METHODS +3600 METHODS +3601 METHODS +3602 METHODS +3603 RESULTS +3604 RESULTS +3605 RESULTS +3606 CONCLUSIONS +3607 CONCLUSIONS +3608 OBJECTIVE +3609 METHODS +3610 METHODS +3611 METHODS +3612 METHODS +3613 RESULTS +3614 RESULTS +3615 RESULTS +3616 RESULTS +3617 RESULTS +3618 CONCLUSIONS +3619 CONCLUSIONS +3620 BACKGROUND +3621 BACKGROUND +3622 OBJECTIVE +3623 RESULTS +3624 METHODS +3625 METHODS +3626 RESULTS +3627 RESULTS +3628 RESULTS +3629 RESULTS +3630 CONCLUSIONS +3631 CONCLUSIONS +3632 BACKGROUND +3633 BACKGROUND +3634 OBJECTIVE +3635 METHODS +3636 METHODS +3637 RESULTS +3638 RESULTS +3639 RESULTS +3640 CONCLUSIONS +3641 OBJECTIVE +3642 METHODS +3643 METHODS +3644 METHODS +3645 RESULTS +3646 RESULTS +3647 CONCLUSIONS +3648 RESULTS +3649 CONCLUSIONS +3650 BACKGROUND +3651 CONCLUSIONS +3652 CONCLUSIONS +3653 BACKGROUND +3654 OBJECTIVE +3655 METHODS +3656 RESULTS +3657 RESULTS +3658 RESULTS +3659 RESULTS +3660 CONCLUSIONS +3661 CONCLUSIONS +3662 BACKGROUND +3663 METHODS +3664 METHODS +3665 METHODS +3666 METHODS +3667 METHODS +3668 METHODS +3669 RESULTS +3670 RESULTS +3671 RESULTS +3672 RESULTS +3673 RESULTS +3674 CONCLUSIONS +3675 BACKGROUND +3676 OBJECTIVE +3677 METHODS +3678 METHODS +3679 METHODS +3680 METHODS +3681 METHODS +3682 RESULTS +3683 RESULTS +3684 RESULTS +3685 CONCLUSIONS +3686 RESULTS +3687 CONCLUSIONS +3688 CONCLUSIONS +3689 BACKGROUND +3690 OBJECTIVE +3691 METHODS +3692 METHODS +3693 METHODS +3694 METHODS +3695 METHODS +3696 RESULTS +3697 RESULTS +3698 RESULTS +3699 RESULTS +3700 CONCLUSIONS +3701 OBJECTIVE +3702 METHODS +3703 METHODS +3704 RESULTS +3705 RESULTS +3706 CONCLUSIONS +3707 CONCLUSIONS +3708 BACKGROUND +3709 BACKGROUND +3710 OBJECTIVE +3711 METHODS +3712 METHODS +3713 METHODS +3714 RESULTS +3715 RESULTS +3716 RESULTS +3717 CONCLUSIONS +3718 BACKGROUND +3719 BACKGROUND +3720 OBJECTIVE +3721 METHODS +3722 METHODS +3723 METHODS +3724 METHODS +3725 METHODS +3726 METHODS +3727 RESULTS +3728 RESULTS +3729 CONCLUSIONS +3730 BACKGROUND +3731 OBJECTIVE +3732 METHODS +3733 METHODS +3734 METHODS +3735 METHODS +3736 RESULTS +3737 RESULTS +3738 RESULTS +3739 RESULTS +3740 CONCLUSIONS +3741 OBJECTIVE +3742 BACKGROUND +3743 METHODS +3744 METHODS +3745 METHODS +3746 RESULTS +3747 RESULTS +3748 RESULTS +3749 RESULTS +3750 RESULTS +3751 CONCLUSIONS +3752 BACKGROUND +3753 BACKGROUND +3754 METHODS +3755 METHODS +3756 METHODS +3757 RESULTS +3758 RESULTS +3759 RESULTS +3760 RESULTS +3761 RESULTS +3762 CONCLUSIONS +3763 CONCLUSIONS +3764 OBJECTIVE +3765 METHODS +3766 RESULTS +3767 RESULTS +3768 RESULTS +3769 RESULTS +3770 CONCLUSIONS +3771 CONCLUSIONS +3772 OBJECTIVE +3773 METHODS +3774 METHODS +3775 METHODS +3776 METHODS +3777 METHODS +3778 METHODS +3779 METHODS +3780 RESULTS +3781 RESULTS +3782 RESULTS +3783 RESULTS +3784 RESULTS +3785 RESULTS +3786 RESULTS +3787 CONCLUSIONS +3788 CONCLUSIONS +3789 BACKGROUND +3790 BACKGROUND +3791 OBJECTIVE +3792 METHODS +3793 METHODS +3794 METHODS +3795 RESULTS +3796 RESULTS +3797 RESULTS +3798 CONCLUSIONS +3799 OBJECTIVE +3800 METHODS +3801 METHODS +3802 METHODS +3803 RESULTS +3804 RESULTS +3805 CONCLUSIONS +3806 OBJECTIVE +3807 METHODS +3808 METHODS +3809 METHODS +3810 METHODS +3811 METHODS +3812 METHODS +3813 RESULTS +3814 RESULTS +3815 RESULTS +3816 RESULTS +3817 RESULTS +3818 RESULTS +3819 CONCLUSIONS +3820 OBJECTIVE +3821 METHODS +3822 METHODS +3823 METHODS +3824 METHODS +3825 METHODS +3826 METHODS +3827 RESULTS +3828 RESULTS +3829 CONCLUSIONS +3830 CONCLUSIONS +3831 OBJECTIVE +3832 METHODS +3833 METHODS +3834 METHODS +3835 METHODS +3836 METHODS +3837 RESULTS +3838 RESULTS +3839 RESULTS +3840 CONCLUSIONS +3841 OBJECTIVE +3842 METHODS +3843 METHODS +3844 METHODS +3845 METHODS +3846 METHODS +3847 RESULTS +3848 RESULTS +3849 RESULTS +3850 RESULTS +3851 RESULTS +3852 RESULTS +3853 RESULTS +3854 CONCLUSIONS +3855 BACKGROUND +3856 OBJECTIVE +3857 METHODS +3858 METHODS +3859 METHODS +3860 RESULTS +3861 RESULTS +3862 CONCLUSIONS +3863 OBJECTIVE +3864 METHODS +3865 METHODS +3866 RESULTS +3867 METHODS +3868 CONCLUSIONS +3869 RESULTS +3870 RESULTS +3871 CONCLUSIONS +3872 CONCLUSIONS +3873 BACKGROUND +3874 BACKGROUND +3875 BACKGROUND +3876 METHODS +3877 METHODS +3878 METHODS +3879 METHODS +3880 METHODS +3881 METHODS +3882 RESULTS +3883 RESULTS +3884 RESULTS +3885 CONCLUSIONS +3886 OBJECTIVE +3887 METHODS +3888 METHODS +3889 METHODS +3890 RESULTS +3891 RESULTS +3892 RESULTS +3893 RESULTS +3894 CONCLUSIONS +3895 CONCLUSIONS +3896 OBJECTIVE +3897 METHODS +3898 METHODS +3899 METHODS +3900 METHODS +3901 METHODS +3902 METHODS +3903 METHODS +3904 METHODS +3905 METHODS +3906 METHODS +3907 RESULTS +3908 RESULTS +3909 RESULTS +3910 RESULTS +3911 CONCLUSIONS +3912 RESULTS +3913 CONCLUSIONS +3914 OBJECTIVE +3915 METHODS +3916 RESULTS +3917 RESULTS +3918 RESULTS +3919 RESULTS +3920 RESULTS +3921 CONCLUSIONS +3922 CONCLUSIONS +3923 CONCLUSIONS +3924 OBJECTIVE +3925 OBJECTIVE +3926 METHODS +3927 RESULTS +3928 RESULTS +3929 RESULTS +3930 RESULTS +3931 RESULTS +3932 CONCLUSIONS +3933 CONCLUSIONS +3934 CONCLUSIONS +3935 BACKGROUND +3936 METHODS +3937 METHODS +3938 RESULTS +3939 RESULTS +3940 RESULTS +3941 RESULTS +3942 RESULTS +3943 CONCLUSIONS +3944 BACKGROUND +3945 METHODS +3946 METHODS +3947 METHODS +3948 METHODS +3949 RESULTS +3950 RESULTS +3951 RESULTS +3952 RESULTS +3953 RESULTS +3954 RESULTS +3955 RESULTS +3956 CONCLUSIONS +3957 OBJECTIVE +3958 BACKGROUND +3959 METHODS +3960 RESULTS +3961 CONCLUSIONS +3962 CONCLUSIONS +3963 BACKGROUND +3964 OBJECTIVE +3965 METHODS +3966 RESULTS +3967 METHODS +3968 METHODS +3969 METHODS +3970 METHODS +3971 RESULTS +3972 RESULTS +3973 CONCLUSIONS +3974 CONCLUSIONS +3975 BACKGROUND +3976 OBJECTIVE +3977 METHODS +3978 METHODS +3979 METHODS +3980 METHODS +3981 METHODS +3982 METHODS +3983 RESULTS +3984 RESULTS +3985 RESULTS +3986 RESULTS +3987 CONCLUSIONS +3988 OBJECTIVE +3989 BACKGROUND +3990 METHODS +3991 METHODS +3992 METHODS +3993 METHODS +3994 RESULTS +3995 RESULTS +3996 RESULTS +3997 RESULTS +3998 RESULTS +3999 RESULTS +4000 CONCLUSIONS +4001 RESULTS +4002 OBJECTIVE +4003 METHODS +4004 METHODS +4005 METHODS +4006 METHODS +4007 METHODS +4008 RESULTS +4009 RESULTS +4010 CONCLUSIONS +4011 OBJECTIVE +4012 BACKGROUND +4013 METHODS +4014 OBJECTIVE +4015 METHODS +4016 METHODS +4017 METHODS +4018 METHODS +4019 METHODS +4020 RESULTS +4021 RESULTS +4022 RESULTS +4023 RESULTS +4024 RESULTS +4025 CONCLUSIONS +4026 CONCLUSIONS +4027 BACKGROUND +4028 OBJECTIVE +4029 METHODS +4030 METHODS +4031 RESULTS +4032 RESULTS +4033 RESULTS +4034 RESULTS +4035 CONCLUSIONS +4036 RESULTS +4037 CONCLUSIONS +4038 OBJECTIVE +4039 METHODS +4040 METHODS +4041 METHODS +4042 METHODS +4043 METHODS +4044 METHODS +4045 RESULTS +4046 RESULTS +4047 RESULTS +4048 RESULTS +4049 CONCLUSIONS +4050 BACKGROUND +4051 RESULTS +4052 RESULTS +4053 RESULTS +4054 RESULTS +4055 CONCLUSIONS +4056 CONCLUSIONS +4057 BACKGROUND +4058 OBJECTIVE +4059 METHODS +4060 METHODS +4061 METHODS +4062 METHODS +4063 RESULTS +4064 RESULTS +4065 METHODS +4066 RESULTS +4067 RESULTS +4068 RESULTS +4069 RESULTS +4070 RESULTS +4071 RESULTS +4072 RESULTS +4073 CONCLUSIONS +4074 RESULTS +4075 RESULTS +4076 BACKGROUND +4077 BACKGROUND +4078 BACKGROUND +4079 METHODS +4080 METHODS +4081 METHODS +4082 METHODS +4083 METHODS +4084 METHODS +4085 CONCLUSIONS +4086 CONCLUSIONS +4087 BACKGROUND +4088 BACKGROUND +4089 METHODS +4090 METHODS +4091 METHODS +4092 METHODS +4093 METHODS +4094 METHODS +4095 RESULTS +4096 RESULTS +4097 RESULTS +4098 RESULTS +4099 CONCLUSIONS +4100 CONCLUSIONS +4101 OBJECTIVE +4102 METHODS +4103 METHODS +4104 METHODS +4105 METHODS +4106 METHODS +4107 METHODS +4108 METHODS +4109 RESULTS +4110 RESULTS +4111 RESULTS +4112 RESULTS +4113 CONCLUSIONS +4114 RESULTS +4115 CONCLUSIONS +4116 BACKGROUND +4117 OBJECTIVE +4118 METHODS +4119 METHODS +4120 METHODS +4121 RESULTS +4122 RESULTS +4123 RESULTS +4124 RESULTS +4125 RESULTS +4126 RESULTS +4127 RESULTS +4128 CONCLUSIONS +4129 OBJECTIVE +4130 BACKGROUND +4131 METHODS +4132 RESULTS +4133 RESULTS +4134 RESULTS +4135 RESULTS +4136 RESULTS +4137 RESULTS +4138 CONCLUSIONS +4139 OBJECTIVE +4140 METHODS +4141 METHODS +4142 METHODS +4143 METHODS +4144 METHODS +4145 METHODS +4146 METHODS +4147 METHODS +4148 METHODS +4149 METHODS +4150 RESULTS +4151 RESULTS +4152 CONCLUSIONS +4153 CONCLUSIONS +4154 CONCLUSIONS +4155 BACKGROUND +4156 OBJECTIVE +4157 METHODS +4158 METHODS +4159 METHODS +4160 RESULTS +4161 RESULTS +4162 RESULTS +4163 RESULTS +4164 CONCLUSIONS +4165 CONCLUSIONS +4166 BACKGROUND +4167 BACKGROUND +4168 METHODS +4169 METHODS +4170 METHODS +4171 RESULTS +4172 RESULTS +4173 RESULTS +4174 CONCLUSIONS +4175 RESULTS +4176 CONCLUSIONS +4177 RESULTS +4178 CONCLUSIONS +4179 CONCLUSIONS +4180 BACKGROUND +4181 BACKGROUND +4182 METHODS +4183 METHODS +4184 METHODS +4185 METHODS +4186 METHODS +4187 RESULTS +4188 METHODS +4189 RESULTS +4190 RESULTS +4191 CONCLUSIONS +4192 CONCLUSIONS +4193 METHODS +4194 METHODS +4195 RESULTS +4196 RESULTS +4197 RESULTS +4198 RESULTS +4199 RESULTS +4200 CONCLUSIONS +4201 RESULTS +4202 CONCLUSIONS +4203 BACKGROUND +4204 BACKGROUND +4205 METHODS +4206 METHODS +4207 METHODS +4208 METHODS +4209 METHODS +4210 RESULTS +4211 RESULTS +4212 RESULTS +4213 RESULTS +4214 RESULTS +4215 CONCLUSIONS +4216 OBJECTIVE +4217 METHODS +4218 METHODS +4219 METHODS +4220 METHODS +4221 RESULTS +4222 RESULTS +4223 CONCLUSIONS +4224 OBJECTIVE +4225 METHODS +4226 METHODS +4227 RESULTS +4228 RESULTS +4229 RESULTS +4230 RESULTS +4231 RESULTS +4232 CONCLUSIONS +4233 RESULTS +4234 OBJECTIVE +4235 METHODS +4236 METHODS +4237 METHODS +4238 RESULTS +4239 RESULTS +4240 RESULTS +4241 CONCLUSIONS +4242 RESULTS +4243 OBJECTIVE +4244 METHODS +4245 METHODS +4246 METHODS +4247 METHODS +4248 METHODS +4249 METHODS +4250 RESULTS +4251 RESULTS +4252 RESULTS +4253 CONCLUSIONS +4254 BACKGROUND +4255 OBJECTIVE +4256 METHODS +4257 METHODS +4258 METHODS +4259 RESULTS +4260 RESULTS +4261 RESULTS +4262 RESULTS +4263 RESULTS +4264 CONCLUSIONS +4265 CONCLUSIONS +4266 RESULTS +4267 BACKGROUND +4268 BACKGROUND +4269 METHODS +4270 METHODS +4271 METHODS +4272 RESULTS +4273 RESULTS +4274 RESULTS +4275 RESULTS +4276 RESULTS +4277 CONCLUSIONS +4278 CONCLUSIONS +4279 OBJECTIVE +4280 METHODS +4281 METHODS +4282 METHODS +4283 METHODS +4284 METHODS +4285 METHODS +4286 RESULTS +4287 RESULTS +4288 RESULTS +4289 RESULTS +4290 RESULTS +4291 CONCLUSIONS +4292 CONCLUSIONS +4293 OBJECTIVE +4294 METHODS +4295 METHODS +4296 METHODS +4297 METHODS +4298 METHODS +4299 METHODS +4300 RESULTS +4301 CONCLUSIONS +4302 RESULTS +4303 CONCLUSIONS +4304 BACKGROUND +4305 BACKGROUND +4306 BACKGROUND +4307 METHODS +4308 METHODS +4309 METHODS +4310 RESULTS +4311 RESULTS +4312 RESULTS +4313 RESULTS +4314 RESULTS +4315 CONCLUSIONS +4316 CONCLUSIONS +4317 BACKGROUND +4318 BACKGROUND +4319 OBJECTIVE +4320 METHODS +4321 METHODS +4322 METHODS +4323 METHODS +4324 RESULTS +4325 RESULTS +4326 RESULTS +4327 RESULTS +4328 RESULTS +4329 CONCLUSIONS +4330 CONCLUSIONS +4331 OBJECTIVE +4332 METHODS +4333 METHODS +4334 METHODS +4335 METHODS +4336 RESULTS +4337 CONCLUSIONS +4338 BACKGROUND +4339 BACKGROUND +4340 CONCLUSIONS +4341 OBJECTIVE +4342 METHODS +4343 METHODS +4344 BACKGROUND +4345 CONCLUSIONS +4346 BACKGROUND +4347 OBJECTIVE +4348 METHODS +4349 METHODS +4350 METHODS +4351 RESULTS +4352 RESULTS +4353 RESULTS +4354 RESULTS +4355 RESULTS +4356 RESULTS +4357 RESULTS +4358 RESULTS +4359 RESULTS +4360 RESULTS +4361 OBJECTIVE +4362 BACKGROUND +4363 BACKGROUND +4364 OBJECTIVE +4365 METHODS +4366 METHODS +4367 METHODS +4368 METHODS +4369 METHODS +4370 METHODS +4371 METHODS +4372 RESULTS +4373 RESULTS +4374 RESULTS +4375 CONCLUSIONS +4376 BACKGROUND +4377 BACKGROUND +4378 BACKGROUND +4379 METHODS +4380 METHODS +4381 METHODS +4382 RESULTS +4383 RESULTS +4384 RESULTS +4385 RESULTS +4386 RESULTS +4387 CONCLUSIONS +4388 CONCLUSIONS +4389 CONCLUSIONS +4390 OBJECTIVE +4391 OBJECTIVE +4392 METHODS +4393 METHODS +4394 METHODS +4395 METHODS +4396 RESULTS +4397 RESULTS +4398 CONCLUSIONS +4399 RESULTS +4400 RESULTS +4401 CONCLUSIONS +4402 CONCLUSIONS +4403 CONCLUSIONS +4404 OBJECTIVE +4405 BACKGROUND +4406 OBJECTIVE +4407 METHODS +4408 METHODS +4409 RESULTS +4410 RESULTS +4411 RESULTS +4412 RESULTS +4413 CONCLUSIONS +4414 CONCLUSIONS +4415 OBJECTIVE +4416 METHODS +4417 RESULTS +4418 METHODS +4419 METHODS +4420 METHODS +4421 RESULTS +4422 RESULTS +4423 RESULTS +4424 RESULTS +4425 RESULTS +4426 RESULTS +4427 RESULTS +4428 RESULTS +4429 RESULTS +4430 RESULTS +4431 RESULTS +4432 RESULTS +4433 RESULTS +4434 RESULTS +4435 RESULTS +4436 RESULTS +4437 OBJECTIVE +4438 METHODS +4439 METHODS +4440 METHODS +4441 METHODS +4442 RESULTS +4443 RESULTS +4444 RESULTS +4445 RESULTS +4446 RESULTS +4447 CONCLUSIONS +4448 BACKGROUND +4449 BACKGROUND +4450 OBJECTIVE +4451 METHODS +4452 METHODS +4453 RESULTS +4454 RESULTS +4455 CONCLUSIONS +4456 BACKGROUND +4457 OBJECTIVE +4458 OBJECTIVE +4459 OBJECTIVE +4460 METHODS +4461 METHODS +4462 METHODS +4463 METHODS +4464 METHODS +4465 RESULTS +4466 RESULTS +4467 RESULTS +4468 RESULTS +4469 RESULTS +4470 RESULTS +4471 CONCLUSIONS +4472 BACKGROUND +4473 OBJECTIVE +4474 METHODS +4475 METHODS +4476 METHODS +4477 METHODS +4478 METHODS +4479 RESULTS +4480 RESULTS +4481 RESULTS +4482 CONCLUSIONS +4483 BACKGROUND +4484 BACKGROUND +4485 OBJECTIVE +4486 METHODS +4487 METHODS +4488 RESULTS +4489 RESULTS +4490 RESULTS +4491 CONCLUSIONS +4492 CONCLUSIONS +4493 OBJECTIVE +4494 METHODS +4495 METHODS +4496 METHODS +4497 RESULTS +4498 RESULTS +4499 RESULTS +4500 RESULTS +4501 RESULTS +4502 CONCLUSIONS +4503 BACKGROUND +4504 BACKGROUND +4505 METHODS +4506 METHODS +4507 RESULTS +4508 RESULTS +4509 RESULTS +4510 CONCLUSIONS +4511 CONCLUSIONS +4512 CONCLUSIONS +4513 BACKGROUND +4514 BACKGROUND +4515 METHODS +4516 OBJECTIVE +4517 METHODS +4518 METHODS +4519 RESULTS +4520 RESULTS +4521 CONCLUSIONS +4522 CONCLUSIONS +4523 OBJECTIVE +4524 METHODS +4525 METHODS +4526 METHODS +4527 RESULTS +4528 RESULTS +4529 CONCLUSIONS +4530 CONCLUSIONS +4531 OBJECTIVE +4532 OBJECTIVE +4533 METHODS +4534 METHODS +4535 RESULTS +4536 RESULTS +4537 RESULTS +4538 RESULTS +4539 CONCLUSIONS +4540 BACKGROUND +4541 CONCLUSIONS +4542 BACKGROUND +4543 METHODS +4544 METHODS +4545 METHODS +4546 METHODS +4547 METHODS +4548 RESULTS +4549 RESULTS +4550 RESULTS +4551 CONCLUSIONS +4552 CONCLUSIONS +4553 OBJECTIVE +4554 METHODS +4555 METHODS +4556 METHODS +4557 METHODS +4558 RESULTS +4559 RESULTS +4560 CONCLUSIONS +4561 BACKGROUND +4562 BACKGROUND +4563 BACKGROUND +4564 RESULTS +4565 RESULTS +4566 CONCLUSIONS +4567 BACKGROUND +4568 METHODS +4569 METHODS +4570 METHODS +4571 METHODS +4572 METHODS +4573 RESULTS +4574 RESULTS +4575 RESULTS +4576 RESULTS +4577 RESULTS +4578 CONCLUSIONS +4579 CONCLUSIONS +4580 CONCLUSIONS +4581 BACKGROUND +4582 OBJECTIVE +4583 METHODS +4584 METHODS +4585 METHODS +4586 METHODS +4587 METHODS +4588 METHODS +4589 RESULTS +4590 RESULTS +4591 RESULTS +4592 CONCLUSIONS +4593 BACKGROUND +4594 BACKGROUND +4595 METHODS +4596 METHODS +4597 METHODS +4598 METHODS +4599 METHODS +4600 METHODS +4601 RESULTS +4602 RESULTS +4603 RESULTS +4604 RESULTS +4605 CONCLUSIONS +4606 CONCLUSIONS +4607 BACKGROUND +4608 METHODS +4609 METHODS +4610 RESULTS +4611 RESULTS +4612 RESULTS +4613 CONCLUSIONS +4614 CONCLUSIONS +4615 OBJECTIVE +4616 METHODS +4617 METHODS +4618 METHODS +4619 METHODS +4620 RESULTS +4621 RESULTS +4622 RESULTS +4623 RESULTS +4624 RESULTS +4625 RESULTS +4626 CONCLUSIONS +4627 BACKGROUND +4628 OBJECTIVE +4629 OBJECTIVE +4630 METHODS +4631 METHODS +4632 CONCLUSIONS +4633 CONCLUSIONS +4634 CONCLUSIONS +4635 METHODS +4636 METHODS +4637 CONCLUSIONS +4638 BACKGROUND +4639 BACKGROUND +4640 CONCLUSIONS +4641 OBJECTIVE +4642 METHODS +4643 METHODS +4644 METHODS +4645 METHODS +4646 RESULTS +4647 RESULTS +4648 RESULTS +4649 CONCLUSIONS +4650 RESULTS +4651 RESULTS +4652 RESULTS +4653 CONCLUSIONS +4654 BACKGROUND +4655 OBJECTIVE +4656 METHODS +4657 METHODS +4658 METHODS +4659 RESULTS +4660 RESULTS +4661 RESULTS +4662 CONCLUSIONS +4663 CONCLUSIONS +4664 BACKGROUND +4665 BACKGROUND +4666 OBJECTIVE +4667 METHODS +4668 METHODS +4669 METHODS +4670 METHODS +4671 METHODS +4672 RESULTS +4673 RESULTS +4674 CONCLUSIONS +4675 CONCLUSIONS +4676 CONCLUSIONS +4677 OBJECTIVE +4678 METHODS +4679 METHODS +4680 METHODS +4681 METHODS +4682 METHODS +4683 METHODS +4684 METHODS +4685 METHODS +4686 METHODS +4687 RESULTS +4688 RESULTS +4689 RESULTS +4690 RESULTS +4691 RESULTS +4692 CONCLUSIONS +4693 CONCLUSIONS +4694 CONCLUSIONS +4695 BACKGROUND +4696 BACKGROUND +4697 BACKGROUND +4698 BACKGROUND +4699 METHODS +4700 METHODS +4701 METHODS +4702 METHODS +4703 METHODS +4704 METHODS +4705 RESULTS +4706 RESULTS +4707 CONCLUSIONS +4708 RESULTS +4709 CONCLUSIONS +4710 CONCLUSIONS +4711 BACKGROUND +4712 BACKGROUND +4713 OBJECTIVE +4714 METHODS +4715 METHODS +4716 METHODS +4717 RESULTS +4718 RESULTS +4719 CONCLUSIONS +4720 OBJECTIVE +4721 METHODS +4722 METHODS +4723 METHODS +4724 METHODS +4725 CONCLUSIONS +4726 RESULTS +4727 RESULTS +4728 RESULTS +4729 RESULTS +4730 RESULTS +4731 RESULTS +4732 CONCLUSIONS +4733 BACKGROUND +4734 METHODS +4735 METHODS +4736 METHODS +4737 RESULTS +4738 RESULTS +4739 RESULTS +4740 CONCLUSIONS +4741 CONCLUSIONS +4742 BACKGROUND +4743 BACKGROUND +4744 BACKGROUND +4745 METHODS +4746 METHODS +4747 METHODS +4748 METHODS +4749 METHODS +4750 RESULTS +4751 RESULTS +4752 RESULTS +4753 RESULTS +4754 CONCLUSIONS +4755 BACKGROUND +4756 BACKGROUND +4757 BACKGROUND +4758 METHODS +4759 METHODS +4760 METHODS +4761 METHODS +4762 RESULTS +4763 RESULTS +4764 RESULTS +4765 CONCLUSIONS +4766 OBJECTIVE +4767 METHODS +4768 METHODS +4769 METHODS +4770 METHODS +4771 METHODS +4772 RESULTS +4773 RESULTS +4774 CONCLUSIONS +4775 CONCLUSIONS +4776 BACKGROUND +4777 OBJECTIVE +4778 BACKGROUND +4779 METHODS +4780 METHODS +4781 METHODS +4782 RESULTS +4783 RESULTS +4784 RESULTS +4785 CONCLUSIONS +4786 OBJECTIVE +4787 METHODS +4788 METHODS +4789 METHODS +4790 METHODS +4791 METHODS +4792 METHODS +4793 RESULTS +4794 RESULTS +4795 RESULTS +4796 CONCLUSIONS +4797 BACKGROUND +4798 BACKGROUND +4799 METHODS +4800 METHODS +4801 METHODS +4802 RESULTS +4803 RESULTS +4804 RESULTS +4805 RESULTS +4806 RESULTS +4807 CONCLUSIONS +4808 BACKGROUND +4809 OBJECTIVE +4810 METHODS +4811 METHODS +4812 METHODS +4813 METHODS +4814 RESULTS +4815 METHODS +4816 RESULTS +4817 CONCLUSIONS +4818 CONCLUSIONS +4819 CONCLUSIONS +4820 BACKGROUND +4821 METHODS +4822 METHODS +4823 METHODS +4824 METHODS +4825 METHODS +4826 RESULTS +4827 RESULTS +4828 RESULTS +4829 CONCLUSIONS +4830 CONCLUSIONS +4831 CONCLUSIONS +4832 OBJECTIVE +4833 METHODS +4834 METHODS +4835 METHODS +4836 METHODS +4837 METHODS +4838 METHODS +4839 METHODS +4840 METHODS +4841 RESULTS +4842 RESULTS +4843 RESULTS +4844 RESULTS +4845 CONCLUSIONS +4846 RESULTS +4847 METHODS +4848 RESULTS +4849 RESULTS +4850 RESULTS +4851 RESULTS +4852 RESULTS +4853 CONCLUSIONS +4854 BACKGROUND +4855 BACKGROUND +4856 METHODS +4857 METHODS +4858 METHODS +4859 METHODS +4860 RESULTS +4861 RESULTS +4862 RESULTS +4863 RESULTS +4864 RESULTS +4865 CONCLUSIONS +4866 BACKGROUND +4867 OBJECTIVE +4868 BACKGROUND +4869 METHODS +4870 RESULTS +4871 METHODS +4872 METHODS +4873 METHODS +4874 METHODS +4875 METHODS +4876 RESULTS +4877 RESULTS +4878 RESULTS +4879 CONCLUSIONS +4880 CONCLUSIONS +4881 CONCLUSIONS +4882 BACKGROUND +4883 BACKGROUND +4884 BACKGROUND +4885 BACKGROUND +4886 METHODS +4887 METHODS +4888 METHODS +4889 METHODS +4890 RESULTS +4891 RESULTS +4892 RESULTS +4893 RESULTS +4894 CONCLUSIONS +4895 BACKGROUND +4896 BACKGROUND +4897 CONCLUSIONS +4898 BACKGROUND +4899 RESULTS +4900 CONCLUSIONS +4901 BACKGROUND +4902 OBJECTIVE +4903 METHODS +4904 METHODS +4905 METHODS +4906 RESULTS +4907 RESULTS +4908 RESULTS +4909 RESULTS +4910 RESULTS +4911 CONCLUSIONS +4912 BACKGROUND +4913 BACKGROUND +4914 METHODS +4915 METHODS +4916 METHODS +4917 METHODS +4918 RESULTS +4919 RESULTS +4920 CONCLUSIONS +4921 CONCLUSIONS +4922 BACKGROUND +4923 OBJECTIVE +4924 OBJECTIVE +4925 METHODS +4926 METHODS +4927 METHODS +4928 METHODS +4929 METHODS +4930 METHODS +4931 RESULTS +4932 RESULTS +4933 CONCLUSIONS +4934 CONCLUSIONS +4935 BACKGROUND +4936 OBJECTIVE +4937 METHODS +4938 METHODS +4939 METHODS +4940 METHODS +4941 METHODS +4942 RESULTS +4943 RESULTS +4944 RESULTS +4945 RESULTS +4946 RESULTS +4947 RESULTS +4948 CONCLUSIONS +4949 RESULTS +4950 CONCLUSIONS +4951 CONCLUSIONS +4952 OBJECTIVE +4953 METHODS +4954 METHODS +4955 METHODS +4956 METHODS +4957 RESULTS +4958 RESULTS +4959 RESULTS +4960 RESULTS +4961 RESULTS +4962 CONCLUSIONS +4963 CONCLUSIONS +4964 CONCLUSIONS +4965 BACKGROUND +4966 OBJECTIVE +4967 METHODS +4968 METHODS +4969 METHODS +4970 METHODS +4971 METHODS +4972 METHODS +4973 RESULTS +4974 RESULTS +4975 RESULTS +4976 CONCLUSIONS +4977 OBJECTIVE +4978 METHODS +4979 METHODS +4980 RESULTS +4981 RESULTS +4982 RESULTS +4983 RESULTS +4984 RESULTS +4985 RESULTS +4986 RESULTS +4987 RESULTS +4988 CONCLUSIONS +4989 CONCLUSIONS +4990 CONCLUSIONS +4991 BACKGROUND +4992 BACKGROUND +4993 METHODS +4994 METHODS +4995 RESULTS +4996 METHODS +4997 OBJECTIVE +4998 RESULTS +4999 RESULTS +5000 RESULTS +5001 CONCLUSIONS +5002 OBJECTIVE +5003 METHODS +5004 METHODS +5005 METHODS +5006 METHODS +5007 METHODS +5008 RESULTS +5009 RESULTS +5010 RESULTS +5011 RESULTS +5012 RESULTS +5013 RESULTS +5014 RESULTS +5015 CONCLUSIONS +5016 BACKGROUND +5017 BACKGROUND +5018 CONCLUSIONS +5019 CONCLUSIONS +5020 CONCLUSIONS +5021 CONCLUSIONS +5022 CONCLUSIONS +5023 BACKGROUND +5024 METHODS +5025 METHODS +5026 METHODS +5027 RESULTS +5028 RESULTS +5029 RESULTS +5030 RESULTS +5031 CONCLUSIONS +5032 OBJECTIVE +5033 METHODS +5034 METHODS +5035 METHODS +5036 RESULTS +5037 RESULTS +5038 RESULTS +5039 RESULTS +5040 RESULTS +5041 CONCLUSIONS +5042 CONCLUSIONS +5043 BACKGROUND +5044 BACKGROUND +5045 BACKGROUND +5046 OBJECTIVE +5047 METHODS +5048 METHODS +5049 RESULTS +5050 RESULTS +5051 RESULTS +5052 RESULTS +5053 RESULTS +5054 RESULTS +5055 RESULTS +5056 CONCLUSIONS +5057 OBJECTIVE +5058 METHODS +5059 METHODS +5060 METHODS +5061 RESULTS +5062 RESULTS +5063 RESULTS +5064 RESULTS +5065 RESULTS +5066 RESULTS +5067 RESULTS +5068 CONCLUSIONS +5069 BACKGROUND +5070 BACKGROUND +5071 BACKGROUND +5072 METHODS +5073 METHODS +5074 METHODS +5075 METHODS +5076 RESULTS +5077 RESULTS +5078 RESULTS +5079 RESULTS +5080 CONCLUSIONS +5081 RESULTS +5082 RESULTS +5083 CONCLUSIONS +5084 CONCLUSIONS +5085 BACKGROUND +5086 OBJECTIVE +5087 METHODS +5088 METHODS +5089 METHODS +5090 OBJECTIVE +5091 METHODS +5092 RESULTS +5093 RESULTS +5094 RESULTS +5095 RESULTS +5096 CONCLUSIONS +5097 CONCLUSIONS +5098 BACKGROUND +5099 BACKGROUND +5100 BACKGROUND +5101 METHODS +5102 METHODS +5103 METHODS +5104 METHODS +5105 METHODS +5106 METHODS +5107 RESULTS +5108 RESULTS +5109 RESULTS +5110 RESULTS +5111 RESULTS +5112 RESULTS +5113 METHODS +5114 METHODS +5115 RESULTS +5116 CONCLUSIONS +5117 CONCLUSIONS +5118 BACKGROUND +5119 OBJECTIVE +5120 METHODS +5121 RESULTS +5122 RESULTS +5123 CONCLUSIONS +5124 BACKGROUND +5125 OBJECTIVE +5126 METHODS +5127 METHODS +5128 METHODS +5129 RESULTS +5130 RESULTS +5131 RESULTS +5132 CONCLUSIONS +5133 OBJECTIVE +5134 BACKGROUND +5135 OBJECTIVE +5136 METHODS +5137 METHODS +5138 METHODS +5139 METHODS +5140 METHODS +5141 RESULTS +5142 RESULTS +5143 RESULTS +5144 RESULTS +5145 CONCLUSIONS +5146 CONCLUSIONS +5147 BACKGROUND +5148 OBJECTIVE +5149 CONCLUSIONS +5150 OBJECTIVE +5151 METHODS +5152 METHODS +5153 METHODS +5154 RESULTS +5155 RESULTS +5156 RESULTS +5157 RESULTS +5158 RESULTS +5159 RESULTS +5160 RESULTS +5161 CONCLUSIONS +5162 BACKGROUND +5163 OBJECTIVE +5164 METHODS +5165 METHODS +5166 METHODS +5167 METHODS +5168 RESULTS +5169 RESULTS +5170 RESULTS +5171 RESULTS +5172 CONCLUSIONS +5173 BACKGROUND +5174 OBJECTIVE +5175 METHODS +5176 METHODS +5177 METHODS +5178 METHODS +5179 RESULTS +5180 RESULTS +5181 RESULTS +5182 RESULTS +5183 CONCLUSIONS +5184 OBJECTIVE +5185 METHODS +5186 METHODS +5187 METHODS +5188 METHODS +5189 METHODS +5190 METHODS +5191 RESULTS +5192 RESULTS +5193 RESULTS +5194 CONCLUSIONS +5195 BACKGROUND +5196 BACKGROUND +5197 OBJECTIVE +5198 METHODS +5199 METHODS +5200 METHODS +5201 METHODS +5202 RESULTS +5203 RESULTS +5204 RESULTS +5205 RESULTS +5206 RESULTS +5207 RESULTS +5208 CONCLUSIONS +5209 BACKGROUND +5210 BACKGROUND +5211 METHODS +5212 METHODS +5213 METHODS +5214 RESULTS +5215 RESULTS +5216 RESULTS +5217 CONCLUSIONS +5218 BACKGROUND +5219 METHODS +5220 METHODS +5221 METHODS +5222 RESULTS +5223 RESULTS +5224 CONCLUSIONS +5225 CONCLUSIONS +5226 BACKGROUND +5227 BACKGROUND +5228 METHODS +5229 METHODS +5230 METHODS +5231 METHODS +5232 METHODS +5233 RESULTS +5234 RESULTS +5235 RESULTS +5236 RESULTS +5237 CONCLUSIONS +5238 CONCLUSIONS +5239 BACKGROUND +5240 BACKGROUND +5241 BACKGROUND +5242 BACKGROUND +5243 BACKGROUND +5244 OBJECTIVE +5245 METHODS +5246 METHODS +5247 METHODS +5248 CONCLUSIONS +5249 CONCLUSIONS +5250 CONCLUSIONS +5251 CONCLUSIONS +5252 BACKGROUND +5253 BACKGROUND +5254 CONCLUSIONS +5255 CONCLUSIONS +5256 BACKGROUND +5257 OBJECTIVE +5258 METHODS +5259 METHODS +5260 METHODS +5261 RESULTS +5262 RESULTS +5263 RESULTS +5264 CONCLUSIONS +5265 CONCLUSIONS +5266 BACKGROUND +5267 BACKGROUND +5268 METHODS +5269 METHODS +5270 METHODS +5271 METHODS +5272 METHODS +5273 RESULTS +5274 RESULTS +5275 RESULTS +5276 RESULTS +5277 RESULTS +5278 RESULTS +5279 RESULTS +5280 CONCLUSIONS +5281 CONCLUSIONS +5282 OBJECTIVE +5283 METHODS +5284 METHODS +5285 METHODS +5286 METHODS +5287 METHODS +5288 RESULTS +5289 RESULTS +5290 RESULTS +5291 RESULTS +5292 CONCLUSIONS +5293 BACKGROUND +5294 BACKGROUND +5295 OBJECTIVE +5296 METHODS +5297 METHODS +5298 METHODS +5299 RESULTS +5300 RESULTS +5301 RESULTS +5302 RESULTS +5303 RESULTS +5304 CONCLUSIONS +5305 BACKGROUND +5306 BACKGROUND +5307 BACKGROUND +5308 BACKGROUND +5309 METHODS +5310 METHODS +5311 METHODS +5312 RESULTS +5313 RESULTS +5314 RESULTS +5315 CONCLUSIONS +5316 CONCLUSIONS +5317 OBJECTIVE +5318 METHODS +5319 METHODS +5320 METHODS +5321 METHODS +5322 METHODS +5323 METHODS +5324 METHODS +5325 RESULTS +5326 RESULTS +5327 RESULTS +5328 RESULTS +5329 RESULTS +5330 RESULTS +5331 RESULTS +5332 CONCLUSIONS +5333 RESULTS +5334 BACKGROUND +5335 BACKGROUND +5336 METHODS +5337 CONCLUSIONS +5338 RESULTS +5339 RESULTS +5340 RESULTS +5341 RESULTS +5342 CONCLUSIONS +5343 CONCLUSIONS +5344 OBJECTIVE +5345 METHODS +5346 METHODS +5347 METHODS +5348 METHODS +5349 METHODS +5350 RESULTS +5351 RESULTS +5352 RESULTS +5353 RESULTS +5354 CONCLUSIONS +5355 BACKGROUND +5356 BACKGROUND +5357 METHODS +5358 CONCLUSIONS +5359 RESULTS +5360 RESULTS +5361 RESULTS +5362 RESULTS +5363 CONCLUSIONS +5364 OBJECTIVE +5365 METHODS +5366 METHODS +5367 METHODS +5368 METHODS +5369 RESULTS +5370 RESULTS +5371 RESULTS +5372 CONCLUSIONS +5373 CONCLUSIONS +5374 OBJECTIVE +5375 BACKGROUND +5376 METHODS +5377 METHODS +5378 METHODS +5379 METHODS +5380 RESULTS +5381 METHODS +5382 RESULTS +5383 RESULTS +5384 CONCLUSIONS +5385 OBJECTIVE +5386 METHODS +5387 METHODS +5388 METHODS +5389 METHODS +5390 RESULTS +5391 RESULTS +5392 RESULTS +5393 RESULTS +5394 RESULTS +5395 CONCLUSIONS +5396 CONCLUSIONS +5397 BACKGROUND +5398 OBJECTIVE +5399 METHODS +5400 METHODS +5401 METHODS +5402 METHODS +5403 METHODS +5404 RESULTS +5405 RESULTS +5406 RESULTS +5407 RESULTS +5408 CONCLUSIONS +5409 BACKGROUND +5410 BACKGROUND +5411 OBJECTIVE +5412 METHODS +5413 RESULTS +5414 RESULTS +5415 CONCLUSIONS +5416 BACKGROUND +5417 BACKGROUND +5418 BACKGROUND +5419 BACKGROUND +5420 METHODS +5421 METHODS +5422 METHODS +5423 RESULTS +5424 RESULTS +5425 RESULTS +5426 CONCLUSIONS +5427 BACKGROUND +5428 BACKGROUND +5429 BACKGROUND +5430 OBJECTIVE +5431 OBJECTIVE +5432 METHODS +5433 METHODS +5434 RESULTS +5435 METHODS +5436 METHODS +5437 RESULTS +5438 RESULTS +5439 RESULTS +5440 CONCLUSIONS +5441 OBJECTIVE +5442 METHODS +5443 METHODS +5444 METHODS +5445 METHODS +5446 METHODS +5447 METHODS +5448 METHODS +5449 METHODS +5450 RESULTS +5451 RESULTS +5452 CONCLUSIONS +5453 RESULTS +5454 RESULTS +5455 RESULTS +5456 RESULTS +5457 RESULTS +5458 CONCLUSIONS +5459 CONCLUSIONS +5460 CONCLUSIONS +5461 CONCLUSIONS +5462 BACKGROUND +5463 METHODS +5464 METHODS +5465 METHODS +5466 CONCLUSIONS +5467 RESULTS +5468 RESULTS +5469 RESULTS +5470 CONCLUSIONS +5471 RESULTS +5472 BACKGROUND +5473 BACKGROUND +5474 METHODS +5475 RESULTS +5476 RESULTS +5477 RESULTS +5478 RESULTS +5479 CONCLUSIONS +5480 BACKGROUND +5481 OBJECTIVE +5482 METHODS +5483 METHODS +5484 METHODS +5485 METHODS +5486 METHODS +5487 METHODS +5488 METHODS +5489 RESULTS +5490 RESULTS +5491 RESULTS +5492 RESULTS +5493 CONCLUSIONS +5494 BACKGROUND +5495 BACKGROUND +5496 OBJECTIVE +5497 METHODS +5498 METHODS +5499 METHODS +5500 RESULTS +5501 RESULTS +5502 RESULTS +5503 RESULTS +5504 CONCLUSIONS +5505 RESULTS +5506 BACKGROUND +5507 OBJECTIVE +5508 METHODS +5509 METHODS +5510 METHODS +5511 METHODS +5512 RESULTS +5513 RESULTS +5514 RESULTS +5515 RESULTS +5516 CONCLUSIONS +5517 OBJECTIVE +5518 METHODS +5519 METHODS +5520 METHODS +5521 RESULTS +5522 RESULTS +5523 RESULTS +5524 RESULTS +5525 CONCLUSIONS +5526 BACKGROUND +5527 BACKGROUND +5528 CONCLUSIONS +5529 BACKGROUND +5530 METHODS +5531 METHODS +5532 METHODS +5533 METHODS +5534 METHODS +5535 RESULTS +5536 RESULTS +5537 RESULTS +5538 RESULTS +5539 RESULTS +5540 CONCLUSIONS +5541 BACKGROUND +5542 METHODS +5543 METHODS +5544 METHODS +5545 RESULTS +5546 RESULTS +5547 RESULTS +5548 RESULTS +5549 CONCLUSIONS +5550 OBJECTIVE +5551 BACKGROUND +5552 METHODS +5553 RESULTS +5554 RESULTS +5555 RESULTS +5556 RESULTS +5557 CONCLUSIONS +5558 OBJECTIVE +5559 METHODS +5560 METHODS +5561 METHODS +5562 METHODS +5563 RESULTS +5564 RESULTS +5565 RESULTS +5566 RESULTS +5567 RESULTS +5568 RESULTS +5569 CONCLUSIONS +5570 CONCLUSIONS +5571 BACKGROUND +5572 METHODS +5573 METHODS +5574 METHODS +5575 METHODS +5576 METHODS +5577 METHODS +5578 RESULTS +5579 RESULTS +5580 RESULTS +5581 RESULTS +5582 CONCLUSIONS +5583 BACKGROUND +5584 BACKGROUND +5585 METHODS +5586 METHODS +5587 METHODS +5588 METHODS +5589 METHODS +5590 METHODS +5591 RESULTS +5592 RESULTS +5593 RESULTS +5594 RESULTS +5595 RESULTS +5596 RESULTS +5597 CONCLUSIONS +5598 OBJECTIVE +5599 METHODS +5600 METHODS +5601 METHODS +5602 METHODS +5603 RESULTS +5604 RESULTS +5605 RESULTS +5606 RESULTS +5607 RESULTS +5608 RESULTS +5609 RESULTS +5610 RESULTS +5611 CONCLUSIONS +5612 BACKGROUND +5613 BACKGROUND +5614 OBJECTIVE +5615 METHODS +5616 METHODS +5617 METHODS +5618 METHODS +5619 METHODS +5620 METHODS +5621 METHODS +5622 RESULTS +5623 RESULTS +5624 RESULTS +5625 RESULTS +5626 CONCLUSIONS +5627 BACKGROUND +5628 OBJECTIVE +5629 OBJECTIVE +5630 METHODS +5631 METHODS +5632 METHODS +5633 METHODS +5634 RESULTS +5635 RESULTS +5636 RESULTS +5637 RESULTS +5638 RESULTS +5639 RESULTS +5640 CONCLUSIONS +5641 RESULTS +5642 OBJECTIVE +5643 METHODS +5644 METHODS +5645 METHODS +5646 METHODS +5647 METHODS +5648 METHODS +5649 METHODS +5650 METHODS +5651 RESULTS +5652 CONCLUSIONS +5653 CONCLUSIONS +5654 BACKGROUND +5655 OBJECTIVE +5656 METHODS +5657 METHODS +5658 RESULTS +5659 RESULTS +5660 RESULTS +5661 CONCLUSIONS +5662 BACKGROUND +5663 BACKGROUND +5664 METHODS +5665 METHODS +5666 RESULTS +5667 RESULTS +5668 RESULTS +5669 RESULTS +5670 CONCLUSIONS +5671 BACKGROUND +5672 OBJECTIVE +5673 METHODS +5674 OBJECTIVE +5675 METHODS +5676 METHODS +5677 METHODS +5678 RESULTS +5679 RESULTS +5680 RESULTS +5681 CONCLUSIONS +5682 CONCLUSIONS +5683 BACKGROUND +5684 BACKGROUND +5685 BACKGROUND +5686 BACKGROUND +5687 METHODS +5688 METHODS +5689 METHODS +5690 METHODS +5691 METHODS +5692 METHODS +5693 METHODS +5694 METHODS +5695 RESULTS +5696 RESULTS +5697 CONCLUSIONS +5698 RESULTS +5699 BACKGROUND +5700 BACKGROUND +5701 BACKGROUND +5702 OBJECTIVE +5703 BACKGROUND +5704 BACKGROUND +5705 METHODS +5706 METHODS +5707 RESULTS +5708 RESULTS +5709 RESULTS +5710 RESULTS +5711 RESULTS +5712 CONCLUSIONS +5713 OBJECTIVE +5714 OBJECTIVE +5715 METHODS +5716 METHODS +5717 METHODS +5718 RESULTS +5719 RESULTS +5720 RESULTS +5721 CONCLUSIONS +5722 BACKGROUND +5723 BACKGROUND +5724 OBJECTIVE +5725 METHODS +5726 METHODS +5727 METHODS +5728 METHODS +5729 RESULTS +5730 CONCLUSIONS +5731 OBJECTIVE +5732 METHODS +5733 METHODS +5734 METHODS +5735 RESULTS +5736 CONCLUSIONS +5737 RESULTS +5738 RESULTS +5739 CONCLUSIONS +5740 OBJECTIVE +5741 METHODS +5742 METHODS +5743 METHODS +5744 METHODS +5745 METHODS +5746 RESULTS +5747 METHODS +5748 RESULTS +5749 RESULTS +5750 RESULTS +5751 RESULTS +5752 RESULTS +5753 RESULTS +5754 RESULTS +5755 CONCLUSIONS +5756 BACKGROUND +5757 BACKGROUND +5758 METHODS +5759 METHODS +5760 RESULTS +5761 RESULTS +5762 RESULTS +5763 RESULTS +5764 CONCLUSIONS +5765 CONCLUSIONS +5766 CONCLUSIONS +5767 BACKGROUND +5768 BACKGROUND +5769 BACKGROUND +5770 OBJECTIVE +5771 METHODS +5772 METHODS +5773 METHODS +5774 METHODS +5775 RESULTS +5776 RESULTS +5777 RESULTS +5778 RESULTS +5779 RESULTS +5780 CONCLUSIONS +5781 CONCLUSIONS +5782 BACKGROUND +5783 BACKGROUND +5784 RESULTS +5785 METHODS +5786 METHODS +5787 RESULTS +5788 RESULTS +5789 CONCLUSIONS +5790 CONCLUSIONS +5791 BACKGROUND +5792 BACKGROUND +5793 BACKGROUND +5794 METHODS +5795 METHODS +5796 METHODS +5797 BACKGROUND +5798 METHODS +5799 METHODS +5800 RESULTS +5801 RESULTS +5802 RESULTS +5803 RESULTS +5804 CONCLUSIONS +5805 BACKGROUND +5806 OBJECTIVE +5807 METHODS +5808 METHODS +5809 METHODS +5810 METHODS +5811 RESULTS +5812 RESULTS +5813 RESULTS +5814 RESULTS +5815 RESULTS +5816 RESULTS +5817 CONCLUSIONS +5818 RESULTS +5819 RESULTS +5820 OBJECTIVE +5821 METHODS +5822 RESULTS +5823 CONCLUSIONS +5824 CONCLUSIONS +5825 BACKGROUND +5826 BACKGROUND +5827 OBJECTIVE +5828 METHODS +5829 METHODS +5830 RESULTS +5831 RESULTS +5832 RESULTS +5833 CONCLUSIONS +5834 CONCLUSIONS +5835 CONCLUSIONS +5836 OBJECTIVE +5837 METHODS +5838 METHODS +5839 METHODS +5840 METHODS +5841 METHODS +5842 METHODS +5843 RESULTS +5844 RESULTS +5845 RESULTS +5846 RESULTS +5847 RESULTS +5848 CONCLUSIONS +5849 OBJECTIVE +5850 METHODS +5851 METHODS +5852 METHODS +5853 RESULTS +5854 RESULTS +5855 RESULTS +5856 RESULTS +5857 METHODS +5858 OBJECTIVE +5859 BACKGROUND +5860 BACKGROUND +5861 BACKGROUND +5862 METHODS +5863 METHODS +5864 METHODS +5865 RESULTS +5866 RESULTS +5867 RESULTS +5868 RESULTS +5869 RESULTS +5870 RESULTS +5871 CONCLUSIONS +5872 RESULTS +5873 CONCLUSIONS +5874 BACKGROUND +5875 BACKGROUND +5876 METHODS +5877 RESULTS +5878 METHODS +5879 METHODS +5880 RESULTS +5881 RESULTS +5882 RESULTS +5883 CONCLUSIONS +5884 OBJECTIVE +5885 METHODS +5886 METHODS +5887 METHODS +5888 METHODS +5889 METHODS +5890 METHODS +5891 METHODS +5892 METHODS +5893 RESULTS +5894 RESULTS +5895 RESULTS +5896 RESULTS +5897 CONCLUSIONS +5898 RESULTS +5899 CONCLUSIONS +5900 CONCLUSIONS +5901 BACKGROUND +5902 OBJECTIVE +5903 METHODS +5904 METHODS +5905 METHODS +5906 METHODS +5907 METHODS +5908 RESULTS +5909 RESULTS +5910 RESULTS +5911 CONCLUSIONS +5912 CONCLUSIONS +5913 BACKGROUND +5914 BACKGROUND +5915 BACKGROUND +5916 BACKGROUND +5917 METHODS +5918 METHODS +5919 METHODS +5920 RESULTS +5921 RESULTS +5922 RESULTS +5923 CONCLUSIONS +5924 CONCLUSIONS +5925 BACKGROUND +5926 OBJECTIVE +5927 METHODS +5928 METHODS +5929 METHODS +5930 METHODS +5931 METHODS +5932 RESULTS +5933 RESULTS +5934 RESULTS +5935 RESULTS +5936 RESULTS +5937 RESULTS +5938 CONCLUSIONS +5939 BACKGROUND +5940 METHODS +5941 RESULTS +5942 RESULTS +5943 RESULTS +5944 RESULTS +5945 RESULTS +5946 RESULTS +5947 CONCLUSIONS +5948 BACKGROUND +5949 BACKGROUND +5950 METHODS +5951 METHODS +5952 METHODS +5953 METHODS +5954 METHODS +5955 METHODS +5956 CONCLUSIONS +5957 CONCLUSIONS +5958 BACKGROUND +5959 BACKGROUND +5960 METHODS +5961 METHODS +5962 METHODS +5963 METHODS +5964 RESULTS +5965 RESULTS +5966 CONCLUSIONS +5967 BACKGROUND +5968 OBJECTIVE +5969 METHODS +5970 METHODS +5971 METHODS +5972 METHODS +5973 METHODS +5974 METHODS +5975 RESULTS +5976 RESULTS +5977 RESULTS +5978 CONCLUSIONS +5979 CONCLUSIONS +5980 OBJECTIVE +5981 OBJECTIVE +5982 METHODS +5983 METHODS +5984 METHODS +5985 METHODS +5986 METHODS +5987 RESULTS +5988 RESULTS +5989 RESULTS +5990 RESULTS +5991 RESULTS +5992 RESULTS +5993 CONCLUSIONS +5994 CONCLUSIONS +5995 BACKGROUND +5996 BACKGROUND +5997 OBJECTIVE +5998 METHODS +5999 METHODS +6000 METHODS +6001 RESULTS +6002 RESULTS +6003 RESULTS +6004 CONCLUSIONS +6005 BACKGROUND +6006 BACKGROUND +6007 BACKGROUND +6008 OBJECTIVE +6009 METHODS +6010 METHODS +6011 METHODS +6012 METHODS +6013 METHODS +6014 METHODS +6015 RESULTS +6016 RESULTS +6017 RESULTS +6018 RESULTS +6019 CONCLUSIONS +6020 BACKGROUND +6021 OBJECTIVE +6022 METHODS +6023 METHODS +6024 METHODS +6025 METHODS +6026 METHODS +6027 METHODS +6028 METHODS +6029 METHODS +6030 METHODS +6031 RESULTS +6032 RESULTS +6033 RESULTS +6034 RESULTS +6035 CONCLUSIONS +6036 CONCLUSIONS +6037 BACKGROUND +6038 BACKGROUND +6039 OBJECTIVE +6040 METHODS +6041 METHODS +6042 METHODS +6043 METHODS +6044 METHODS +6045 METHODS +6046 METHODS +6047 METHODS +6048 METHODS +6049 RESULTS +6050 RESULTS +6051 CONCLUSIONS +6052 CONCLUSIONS +6053 BACKGROUND +6054 OBJECTIVE +6055 METHODS +6056 METHODS +6057 RESULTS +6058 RESULTS +6059 CONCLUSIONS +6060 OBJECTIVE +6061 METHODS +6062 METHODS +6063 RESULTS +6064 RESULTS +6065 CONCLUSIONS +6066 OBJECTIVE +6067 CONCLUSIONS +6068 CONCLUSIONS +6069 METHODS +6070 METHODS +6071 METHODS +6072 RESULTS +6073 RESULTS +6074 RESULTS +6075 RESULTS +6076 RESULTS +6077 RESULTS +6078 RESULTS +6079 CONCLUSIONS +6080 OBJECTIVE +6081 METHODS +6082 METHODS +6083 METHODS +6084 METHODS +6085 METHODS +6086 RESULTS +6087 METHODS +6088 METHODS +6089 METHODS +6090 RESULTS +6091 RESULTS +6092 RESULTS +6093 RESULTS +6094 RESULTS +6095 RESULTS +6096 RESULTS +6097 RESULTS +6098 BACKGROUND +6099 CONCLUSIONS +6100 OBJECTIVE +6101 OBJECTIVE +6102 METHODS +6103 METHODS +6104 METHODS +6105 METHODS +6106 METHODS +6107 RESULTS +6108 METHODS +6109 METHODS +6110 RESULTS +6111 RESULTS +6112 RESULTS +6113 RESULTS +6114 RESULTS +6115 RESULTS +6116 RESULTS +6117 CONCLUSIONS +6118 CONCLUSIONS +6119 CONCLUSIONS +6120 OBJECTIVE +6121 BACKGROUND +6122 OBJECTIVE +6123 METHODS +6124 METHODS +6125 METHODS +6126 METHODS +6127 RESULTS +6128 RESULTS +6129 RESULTS +6130 RESULTS +6131 RESULTS +6132 CONCLUSIONS +6133 CONCLUSIONS +6134 BACKGROUND +6135 BACKGROUND +6136 METHODS +6137 RESULTS +6138 RESULTS +6139 CONCLUSIONS +6140 CONCLUSIONS +6141 OBJECTIVE +6142 METHODS +6143 METHODS +6144 RESULTS +6145 CONCLUSIONS +6146 BACKGROUND +6147 BACKGROUND +6148 OBJECTIVE +6149 METHODS +6150 METHODS +6151 RESULTS +6152 RESULTS +6153 RESULTS +6154 CONCLUSIONS +6155 CONCLUSIONS +6156 CONCLUSIONS +6157 METHODS +6158 METHODS +6159 METHODS +6160 METHODS +6161 RESULTS +6162 RESULTS +6163 RESULTS +6164 RESULTS +6165 CONCLUSIONS +6166 CONCLUSIONS +6167 BACKGROUND +6168 BACKGROUND +6169 BACKGROUND +6170 METHODS +6171 METHODS +6172 RESULTS +6173 RESULTS +6174 RESULTS +6175 CONCLUSIONS +6176 BACKGROUND +6177 BACKGROUND +6178 OBJECTIVE +6179 METHODS +6180 METHODS +6181 METHODS +6182 METHODS +6183 METHODS +6184 RESULTS +6185 RESULTS +6186 RESULTS +6187 RESULTS +6188 CONCLUSIONS +6189 CONCLUSIONS +6190 OBJECTIVE +6191 METHODS +6192 RESULTS +6193 RESULTS +6194 RESULTS +6195 RESULTS +6196 CONCLUSIONS +6197 CONCLUSIONS +6198 BACKGROUND +6199 BACKGROUND +6200 OBJECTIVE +6201 METHODS +6202 METHODS +6203 METHODS +6204 METHODS +6205 RESULTS +6206 RESULTS +6207 RESULTS +6208 RESULTS +6209 RESULTS +6210 CONCLUSIONS +6211 BACKGROUND +6212 OBJECTIVE +6213 METHODS +6214 METHODS +6215 METHODS +6216 RESULTS +6217 RESULTS +6218 RESULTS +6219 CONCLUSIONS +6220 CONCLUSIONS +6221 METHODS +6222 OBJECTIVE +6223 METHODS +6224 METHODS +6225 METHODS +6226 METHODS +6227 RESULTS +6228 RESULTS +6229 CONCLUSIONS +6230 CONCLUSIONS +6231 OBJECTIVE +6232 METHODS +6233 RESULTS +6234 RESULTS +6235 RESULTS +6236 RESULTS +6237 CONCLUSIONS +6238 BACKGROUND +6239 BACKGROUND +6240 BACKGROUND +6241 OBJECTIVE +6242 METHODS +6243 METHODS +6244 METHODS +6245 RESULTS +6246 RESULTS +6247 RESULTS +6248 RESULTS +6249 RESULTS +6250 CONCLUSIONS +6251 CONCLUSIONS +6252 OBJECTIVE +6253 METHODS +6254 METHODS +6255 METHODS +6256 METHODS +6257 METHODS +6258 METHODS +6259 RESULTS +6260 RESULTS +6261 CONCLUSIONS +6262 BACKGROUND +6263 BACKGROUND +6264 OBJECTIVE +6265 METHODS +6266 METHODS +6267 RESULTS +6268 RESULTS +6269 CONCLUSIONS +6270 CONCLUSIONS +6271 BACKGROUND +6272 OBJECTIVE +6273 METHODS +6274 METHODS +6275 METHODS +6276 METHODS +6277 METHODS +6278 RESULTS +6279 RESULTS +6280 CONCLUSIONS +6281 OBJECTIVE +6282 METHODS +6283 METHODS +6284 METHODS +6285 METHODS +6286 RESULTS +6287 RESULTS +6288 RESULTS +6289 RESULTS +6290 CONCLUSIONS +6291 RESULTS +6292 OBJECTIVE +6293 METHODS +6294 METHODS +6295 METHODS +6296 RESULTS +6297 RESULTS +6298 CONCLUSIONS +6299 OBJECTIVE +6300 METHODS +6301 METHODS +6302 METHODS +6303 RESULTS +6304 RESULTS +6305 CONCLUSIONS +6306 BACKGROUND +6307 OBJECTIVE +6308 METHODS +6309 METHODS +6310 METHODS +6311 METHODS +6312 RESULTS +6313 RESULTS +6314 RESULTS +6315 RESULTS +6316 CONCLUSIONS +6317 CONCLUSIONS +6318 CONCLUSIONS +6319 CONCLUSIONS +6320 BACKGROUND +6321 METHODS +6322 METHODS +6323 METHODS +6324 METHODS +6325 METHODS +6326 METHODS +6327 METHODS +6328 RESULTS +6329 RESULTS +6330 RESULTS +6331 RESULTS +6332 RESULTS +6333 CONCLUSIONS +6334 BACKGROUND +6335 BACKGROUND +6336 BACKGROUND +6337 METHODS +6338 METHODS +6339 METHODS +6340 RESULTS +6341 RESULTS +6342 RESULTS +6343 CONCLUSIONS +6344 RESULTS +6345 CONCLUSIONS +6346 CONCLUSIONS +6347 OBJECTIVE +6348 METHODS +6349 METHODS +6350 METHODS +6351 METHODS +6352 METHODS +6353 METHODS +6354 METHODS +6355 RESULTS +6356 RESULTS +6357 RESULTS +6358 RESULTS +6359 CONCLUSIONS +6360 RESULTS +6361 CONCLUSIONS +6362 OBJECTIVE +6363 METHODS +6364 METHODS +6365 METHODS +6366 METHODS +6367 METHODS +6368 RESULTS +6369 RESULTS +6370 RESULTS +6371 RESULTS +6372 RESULTS +6373 RESULTS +6374 CONCLUSIONS +6375 BACKGROUND +6376 METHODS +6377 METHODS +6378 RESULTS +6379 METHODS +6380 METHODS +6381 RESULTS +6382 RESULTS +6383 RESULTS +6384 RESULTS +6385 CONCLUSIONS +6386 RESULTS +6387 RESULTS +6388 CONCLUSIONS +6389 CONCLUSIONS +6390 CONCLUSIONS +6391 BACKGROUND +6392 BACKGROUND +6393 METHODS +6394 METHODS +6395 METHODS +6396 METHODS +6397 METHODS +6398 METHODS +6399 METHODS +6400 METHODS +6401 METHODS +6402 CONCLUSIONS +6403 CONCLUSIONS +6404 BACKGROUND +6405 BACKGROUND +6406 OBJECTIVE +6407 METHODS +6408 METHODS +6409 RESULTS +6410 METHODS +6411 RESULTS +6412 RESULTS +6413 RESULTS +6414 CONCLUSIONS +6415 CONCLUSIONS +6416 BACKGROUND +6417 OBJECTIVE +6418 BACKGROUND +6419 METHODS +6420 METHODS +6421 METHODS +6422 METHODS +6423 METHODS +6424 METHODS +6425 RESULTS +6426 RESULTS +6427 RESULTS +6428 RESULTS +6429 RESULTS +6430 CONCLUSIONS +6431 BACKGROUND +6432 OBJECTIVE +6433 METHODS +6434 METHODS +6435 METHODS +6436 METHODS +6437 RESULTS +6438 RESULTS +6439 RESULTS +6440 CONCLUSIONS +6441 BACKGROUND +6442 BACKGROUND +6443 BACKGROUND +6444 METHODS +6445 METHODS +6446 RESULTS +6447 RESULTS +6448 RESULTS +6449 RESULTS +6450 CONCLUSIONS +6451 RESULTS +6452 RESULTS +6453 CONCLUSIONS +6454 CONCLUSIONS +6455 CONCLUSIONS +6456 OBJECTIVE +6457 METHODS +6458 METHODS +6459 METHODS +6460 RESULTS +6461 RESULTS +6462 RESULTS +6463 RESULTS +6464 RESULTS +6465 CONCLUSIONS +6466 RESULTS +6467 CONCLUSIONS +6468 OBJECTIVE +6469 METHODS +6470 METHODS +6471 METHODS +6472 METHODS +6473 METHODS +6474 RESULTS +6475 RESULTS +6476 RESULTS +6477 RESULTS +6478 CONCLUSIONS +6479 CONCLUSIONS +6480 OBJECTIVE +6481 METHODS +6482 METHODS +6483 METHODS +6484 METHODS +6485 RESULTS +6486 RESULTS +6487 RESULTS +6488 RESULTS +6489 RESULTS +6490 RESULTS +6491 CONCLUSIONS +6492 BACKGROUND +6493 OBJECTIVE +6494 BACKGROUND +6495 OBJECTIVE +6496 METHODS +6497 METHODS +6498 METHODS +6499 METHODS +6500 RESULTS +6501 RESULTS +6502 RESULTS +6503 CONCLUSIONS +6504 CONCLUSIONS +6505 OBJECTIVE +6506 METHODS +6507 METHODS +6508 RESULTS +6509 RESULTS +6510 RESULTS +6511 CONCLUSIONS +6512 OBJECTIVE +6513 METHODS +6514 METHODS +6515 METHODS +6516 METHODS +6517 METHODS +6518 RESULTS +6519 RESULTS +6520 CONCLUSIONS +6521 CONCLUSIONS +6522 OBJECTIVE +6523 OBJECTIVE +6524 METHODS +6525 METHODS +6526 RESULTS +6527 RESULTS +6528 RESULTS +6529 RESULTS +6530 RESULTS +6531 RESULTS +6532 RESULTS +6533 CONCLUSIONS +6534 CONCLUSIONS +6535 OBJECTIVE +6536 METHODS +6537 METHODS +6538 METHODS +6539 METHODS +6540 METHODS +6541 METHODS +6542 RESULTS +6543 RESULTS +6544 RESULTS +6545 RESULTS +6546 RESULTS +6547 RESULTS +6548 CONCLUSIONS +6549 CONCLUSIONS +6550 CONCLUSIONS +6551 OBJECTIVE +6552 METHODS +6553 METHODS +6554 RESULTS +6555 RESULTS +6556 CONCLUSIONS +6557 BACKGROUND +6558 OBJECTIVE +6559 METHODS +6560 METHODS +6561 METHODS +6562 METHODS +6563 RESULTS +6564 CONCLUSIONS +6565 OBJECTIVE +6566 METHODS +6567 METHODS +6568 RESULTS +6569 RESULTS +6570 RESULTS +6571 CONCLUSIONS +6572 CONCLUSIONS +6573 BACKGROUND +6574 BACKGROUND +6575 BACKGROUND +6576 METHODS +6577 METHODS +6578 METHODS +6579 RESULTS +6580 METHODS +6581 RESULTS +6582 METHODS +6583 METHODS +6584 RESULTS +6585 RESULTS +6586 RESULTS +6587 RESULTS +6588 RESULTS +6589 CONCLUSIONS +6590 RESULTS +6591 METHODS +6592 METHODS +6593 OBJECTIVE +6594 METHODS +6595 METHODS +6596 METHODS +6597 RESULTS +6598 CONCLUSIONS +6599 RESULTS +6600 RESULTS +6601 METHODS +6602 OBJECTIVE +6603 BACKGROUND +6604 METHODS +6605 METHODS +6606 METHODS +6607 RESULTS +6608 RESULTS +6609 RESULTS +6610 RESULTS +6611 CONCLUSIONS +6612 OBJECTIVE +6613 METHODS +6614 METHODS +6615 METHODS +6616 METHODS +6617 METHODS +6618 METHODS +6619 RESULTS +6620 RESULTS +6621 CONCLUSIONS +6622 CONCLUSIONS +6623 OBJECTIVE +6624 METHODS +6625 METHODS +6626 METHODS +6627 RESULTS +6628 CONCLUSIONS +6629 BACKGROUND +6630 OBJECTIVE +6631 METHODS +6632 METHODS +6633 METHODS +6634 METHODS +6635 RESULTS +6636 METHODS +6637 RESULTS +6638 RESULTS +6639 RESULTS +6640 RESULTS +6641 CONCLUSIONS +6642 BACKGROUND +6643 BACKGROUND +6644 OBJECTIVE +6645 METHODS +6646 METHODS +6647 RESULTS +6648 RESULTS +6649 RESULTS +6650 CONCLUSIONS +6651 BACKGROUND +6652 OBJECTIVE +6653 METHODS +6654 RESULTS +6655 METHODS +6656 RESULTS +6657 RESULTS +6658 RESULTS +6659 RESULTS +6660 CONCLUSIONS +6661 BACKGROUND +6662 BACKGROUND +6663 BACKGROUND +6664 METHODS +6665 METHODS +6666 METHODS +6667 METHODS +6668 RESULTS +6669 RESULTS +6670 RESULTS +6671 RESULTS +6672 RESULTS +6673 RESULTS +6674 CONCLUSIONS +6675 CONCLUSIONS +6676 BACKGROUND +6677 OBJECTIVE +6678 METHODS +6679 METHODS +6680 RESULTS +6681 RESULTS +6682 RESULTS +6683 RESULTS +6684 CONCLUSIONS +6685 CONCLUSIONS +6686 BACKGROUND +6687 BACKGROUND +6688 OBJECTIVE +6689 METHODS +6690 METHODS +6691 METHODS +6692 RESULTS +6693 RESULTS +6694 CONCLUSIONS +6695 BACKGROUND +6696 BACKGROUND +6697 BACKGROUND +6698 METHODS +6699 METHODS +6700 METHODS +6701 RESULTS +6702 RESULTS +6703 CONCLUSIONS +6704 OBJECTIVE +6705 CONCLUSIONS +6706 BACKGROUND +6707 BACKGROUND +6708 OBJECTIVE +6709 METHODS +6710 RESULTS +6711 CONCLUSIONS +6712 BACKGROUND +6713 BACKGROUND +6714 BACKGROUND +6715 METHODS +6716 METHODS +6717 METHODS +6718 RESULTS +6719 RESULTS +6720 METHODS +6721 RESULTS +6722 RESULTS +6723 RESULTS +6724 RESULTS +6725 RESULTS +6726 CONCLUSIONS +6727 RESULTS +6728 BACKGROUND +6729 BACKGROUND +6730 OBJECTIVE +6731 METHODS +6732 METHODS +6733 METHODS +6734 METHODS +6735 RESULTS +6736 RESULTS +6737 RESULTS +6738 RESULTS +6739 CONCLUSIONS +6740 CONCLUSIONS +6741 CONCLUSIONS +6742 BACKGROUND +6743 BACKGROUND +6744 METHODS +6745 METHODS +6746 METHODS +6747 METHODS +6748 METHODS +6749 RESULTS +6750 RESULTS +6751 CONCLUSIONS +6752 CONCLUSIONS +6753 OBJECTIVE +6754 METHODS +6755 RESULTS +6756 METHODS +6757 METHODS +6758 METHODS +6759 METHODS +6760 METHODS +6761 RESULTS +6762 RESULTS +6763 RESULTS +6764 RESULTS +6765 CONCLUSIONS +6766 BACKGROUND +6767 METHODS +6768 RESULTS +6769 CONCLUSIONS +6770 OBJECTIVE +6771 METHODS +6772 METHODS +6773 METHODS +6774 METHODS +6775 RESULTS +6776 RESULTS +6777 RESULTS +6778 CONCLUSIONS +6779 OBJECTIVE +6780 METHODS +6781 RESULTS +6782 RESULTS +6783 RESULTS +6784 RESULTS +6785 CONCLUSIONS +6786 CONCLUSIONS +6787 OBJECTIVE +6788 METHODS +6789 METHODS +6790 METHODS +6791 METHODS +6792 METHODS +6793 METHODS +6794 METHODS +6795 METHODS +6796 METHODS +6797 RESULTS +6798 RESULTS +6799 RESULTS +6800 RESULTS +6801 RESULTS +6802 RESULTS +6803 RESULTS +6804 RESULTS +6805 RESULTS +6806 CONCLUSIONS +6807 OBJECTIVE +6808 METHODS +6809 METHODS +6810 METHODS +6811 BACKGROUND +6812 BACKGROUND +6813 RESULTS +6814 RESULTS +6815 RESULTS +6816 RESULTS +6817 CONCLUSIONS +6818 RESULTS +6819 CONCLUSIONS +6820 OBJECTIVE +6821 METHODS +6822 METHODS +6823 METHODS +6824 METHODS +6825 METHODS +6826 RESULTS +6827 RESULTS +6828 RESULTS +6829 RESULTS +6830 RESULTS +6831 CONCLUSIONS +6832 CONCLUSIONS +6833 CONCLUSIONS +6834 OBJECTIVE +6835 METHODS +6836 METHODS +6837 METHODS +6838 RESULTS +6839 RESULTS +6840 RESULTS +6841 RESULTS +6842 CONCLUSIONS +6843 CONCLUSIONS +6844 BACKGROUND +6845 METHODS +6846 RESULTS +6847 METHODS +6848 RESULTS +6849 RESULTS +6850 RESULTS +6851 RESULTS +6852 RESULTS +6853 RESULTS +6854 RESULTS +6855 CONCLUSIONS +6856 BACKGROUND +6857 OBJECTIVE +6858 METHODS +6859 RESULTS +6860 METHODS +6861 METHODS +6862 RESULTS +6863 RESULTS +6864 RESULTS +6865 RESULTS +6866 CONCLUSIONS +6867 CONCLUSIONS +6868 OBJECTIVE +6869 METHODS +6870 METHODS +6871 METHODS +6872 METHODS +6873 RESULTS +6874 RESULTS +6875 CONCLUSIONS +6876 CONCLUSIONS +6877 OBJECTIVE +6878 METHODS +6879 METHODS +6880 METHODS +6881 RESULTS +6882 RESULTS +6883 RESULTS +6884 RESULTS +6885 BACKGROUND +6886 CONCLUSIONS +6887 CONCLUSIONS +6888 OBJECTIVE +6889 METHODS +6890 METHODS +6891 METHODS +6892 METHODS +6893 METHODS +6894 RESULTS +6895 RESULTS +6896 METHODS +6897 RESULTS +6898 RESULTS +6899 RESULTS +6900 RESULTS +6901 RESULTS +6902 RESULTS +6903 OBJECTIVE +6904 BACKGROUND +6905 METHODS +6906 METHODS +6907 METHODS +6908 RESULTS +6909 RESULTS +6910 RESULTS +6911 CONCLUSIONS +6912 OBJECTIVE +6913 METHODS +6914 METHODS +6915 RESULTS +6916 RESULTS +6917 RESULTS +6918 RESULTS +6919 RESULTS +6920 CONCLUSIONS +6921 BACKGROUND +6922 BACKGROUND +6923 OBJECTIVE +6924 METHODS +6925 METHODS +6926 METHODS +6927 METHODS +6928 RESULTS +6929 RESULTS +6930 RESULTS +6931 RESULTS +6932 RESULTS +6933 BACKGROUND +6934 CONCLUSIONS +6935 CONCLUSIONS +6936 METHODS +6937 OBJECTIVE +6938 BACKGROUND +6939 BACKGROUND +6940 METHODS +6941 METHODS +6942 RESULTS +6943 RESULTS +6944 RESULTS +6945 RESULTS +6946 RESULTS +6947 RESULTS +6948 RESULTS +6949 CONCLUSIONS +6950 CONCLUSIONS +6951 METHODS +6952 OBJECTIVE +6953 METHODS +6954 METHODS +6955 METHODS +6956 METHODS +6957 METHODS +6958 METHODS +6959 RESULTS +6960 RESULTS +6961 CONCLUSIONS +6962 CONCLUSIONS +6963 CONCLUSIONS +6964 OBJECTIVE +6965 METHODS +6966 METHODS +6967 RESULTS +6968 RESULTS +6969 RESULTS +6970 CONCLUSIONS +6971 BACKGROUND +6972 BACKGROUND +6973 METHODS +6974 METHODS +6975 BACKGROUND +6976 BACKGROUND +6977 BACKGROUND +6978 CONCLUSIONS +6979 BACKGROUND +6980 CONCLUSIONS +6981 CONCLUSIONS +6982 OBJECTIVE +6983 METHODS +6984 METHODS +6985 METHODS +6986 METHODS +6987 METHODS +6988 METHODS +6989 METHODS +6990 RESULTS +6991 RESULTS +6992 RESULTS +6993 RESULTS +6994 CONCLUSIONS +6995 BACKGROUND +6996 BACKGROUND +6997 BACKGROUND +6998 METHODS +6999 METHODS +7000 METHODS +7001 RESULTS +7002 RESULTS +7003 RESULTS +7004 RESULTS +7005 RESULTS +7006 RESULTS +7007 CONCLUSIONS +7008 CONCLUSIONS +7009 CONCLUSIONS +7010 BACKGROUND +7011 CONCLUSIONS +7012 OBJECTIVE +7013 METHODS +7014 METHODS +7015 METHODS +7016 METHODS +7017 RESULTS +7018 RESULTS +7019 RESULTS +7020 CONCLUSIONS +7021 BACKGROUND +7022 BACKGROUND +7023 METHODS +7024 METHODS +7025 METHODS +7026 METHODS +7027 RESULTS +7028 RESULTS +7029 RESULTS +7030 RESULTS +7031 CONCLUSIONS +7032 METHODS +7033 BACKGROUND +7034 OBJECTIVE +7035 METHODS +7036 METHODS +7037 METHODS +7038 RESULTS +7039 RESULTS +7040 RESULTS +7041 RESULTS +7042 RESULTS +7043 CONCLUSIONS +7044 OBJECTIVE +7045 METHODS +7046 RESULTS +7047 RESULTS +7048 RESULTS +7049 RESULTS +7050 CONCLUSIONS +7051 CONCLUSIONS +7052 OBJECTIVE +7053 METHODS +7054 RESULTS +7055 RESULTS +7056 RESULTS +7057 CONCLUSIONS +7058 OBJECTIVE +7059 METHODS +7060 METHODS +7061 METHODS +7062 METHODS +7063 METHODS +7064 RESULTS +7065 RESULTS +7066 RESULTS +7067 RESULTS +7068 RESULTS +7069 RESULTS +7070 CONCLUSIONS +7071 RESULTS +7072 BACKGROUND +7073 CONCLUSIONS +7074 METHODS +7075 METHODS +7076 RESULTS +7077 RESULTS +7078 RESULTS +7079 CONCLUSIONS +7080 BACKGROUND +7081 METHODS +7082 METHODS +7083 METHODS +7084 METHODS +7085 METHODS +7086 RESULTS +7087 RESULTS +7088 RESULTS +7089 CONCLUSIONS +7090 RESULTS +7091 CONCLUSIONS +7092 BACKGROUND +7093 METHODS +7094 METHODS +7095 METHODS +7096 METHODS +7097 METHODS +7098 RESULTS +7099 RESULTS +7100 RESULTS +7101 CONCLUSIONS +7102 CONCLUSIONS +7103 OBJECTIVE +7104 METHODS +7105 METHODS +7106 METHODS +7107 METHODS +7108 METHODS +7109 RESULTS +7110 RESULTS +7111 RESULTS +7112 RESULTS +7113 RESULTS +7114 CONCLUSIONS +7115 RESULTS +7116 BACKGROUND +7117 OBJECTIVE +7118 METHODS +7119 METHODS +7120 RESULTS +7121 RESULTS +7122 RESULTS +7123 CONCLUSIONS +7124 OBJECTIVE +7125 METHODS +7126 METHODS +7127 METHODS +7128 METHODS +7129 RESULTS +7130 RESULTS +7131 RESULTS +7132 RESULTS +7133 RESULTS +7134 RESULTS +7135 CONCLUSIONS +7136 BACKGROUND +7137 OBJECTIVE +7138 METHODS +7139 METHODS +7140 METHODS +7141 METHODS +7142 METHODS +7143 RESULTS +7144 RESULTS +7145 RESULTS +7146 RESULTS +7147 RESULTS +7148 RESULTS +7149 CONCLUSIONS +7150 OBJECTIVE +7151 METHODS +7152 METHODS +7153 METHODS +7154 METHODS +7155 METHODS +7156 METHODS +7157 METHODS +7158 RESULTS +7159 RESULTS +7160 RESULTS +7161 RESULTS +7162 RESULTS +7163 RESULTS +7164 RESULTS +7165 CONCLUSIONS +7166 CONCLUSIONS +7167 CONCLUSIONS +7168 BACKGROUND +7169 OBJECTIVE +7170 METHODS +7171 RESULTS +7172 METHODS +7173 RESULTS +7174 RESULTS +7175 RESULTS +7176 RESULTS +7177 RESULTS +7178 RESULTS +7179 CONCLUSIONS +7180 BACKGROUND +7181 BACKGROUND +7182 METHODS +7183 METHODS +7184 METHODS +7185 METHODS +7186 METHODS +7187 RESULTS +7188 RESULTS +7189 RESULTS +7190 RESULTS +7191 CONCLUSIONS +7192 BACKGROUND +7193 BACKGROUND +7194 BACKGROUND +7195 BACKGROUND +7196 BACKGROUND +7197 METHODS +7198 METHODS +7199 RESULTS +7200 RESULTS +7201 CONCLUSIONS +7202 BACKGROUND +7203 OBJECTIVE +7204 METHODS +7205 METHODS +7206 METHODS +7207 METHODS +7208 RESULTS +7209 CONCLUSIONS +7210 CONCLUSIONS +7211 OBJECTIVE +7212 METHODS +7213 METHODS +7214 METHODS +7215 RESULTS +7216 RESULTS +7217 RESULTS +7218 RESULTS +7219 RESULTS +7220 RESULTS +7221 RESULTS +7222 RESULTS +7223 RESULTS +7224 RESULTS +7225 CONCLUSIONS +7226 CONCLUSIONS +7227 OBJECTIVE +7228 CONCLUSIONS +7229 OBJECTIVE +7230 METHODS +7231 RESULTS +7232 METHODS +7233 METHODS +7234 METHODS +7235 METHODS +7236 METHODS +7237 METHODS +7238 RESULTS +7239 RESULTS +7240 RESULTS +7241 RESULTS +7242 RESULTS +7243 RESULTS +7244 RESULTS +7245 CONCLUSIONS +7246 CONCLUSIONS +7247 OBJECTIVE +7248 BACKGROUND +7249 OBJECTIVE +7250 METHODS +7251 METHODS +7252 RESULTS +7253 RESULTS +7254 RESULTS +7255 METHODS +7256 RESULTS +7257 CONCLUSIONS +7258 BACKGROUND +7259 BACKGROUND +7260 METHODS +7261 METHODS +7262 METHODS +7263 METHODS +7264 METHODS +7265 CONCLUSIONS +7266 METHODS +7267 METHODS +7268 METHODS +7269 METHODS +7270 METHODS +7271 CONCLUSIONS +7272 CONCLUSIONS +7273 CONCLUSIONS +7274 BACKGROUND +7275 METHODS +7276 METHODS +7277 METHODS +7278 METHODS +7279 RESULTS +7280 RESULTS +7281 RESULTS +7282 RESULTS +7283 CONCLUSIONS +7284 CONCLUSIONS +7285 OBJECTIVE +7286 METHODS +7287 METHODS +7288 METHODS +7289 METHODS +7290 RESULTS +7291 RESULTS +7292 RESULTS +7293 RESULTS +7294 CONCLUSIONS +7295 BACKGROUND +7296 CONCLUSIONS +7297 OBJECTIVE +7298 METHODS +7299 METHODS +7300 METHODS +7301 METHODS +7302 METHODS +7303 METHODS +7304 METHODS +7305 METHODS +7306 METHODS +7307 METHODS +7308 RESULTS +7309 RESULTS +7310 RESULTS +7311 RESULTS +7312 RESULTS +7313 RESULTS +7314 CONCLUSIONS +7315 OBJECTIVE +7316 METHODS +7317 METHODS +7318 METHODS +7319 RESULTS +7320 METHODS +7321 METHODS +7322 METHODS +7323 RESULTS +7324 RESULTS +7325 RESULTS +7326 RESULTS +7327 CONCLUSIONS +7328 CONCLUSIONS +7329 OBJECTIVE +7330 METHODS +7331 METHODS +7332 RESULTS +7333 RESULTS +7334 CONCLUSIONS +7335 CONCLUSIONS +7336 CONCLUSIONS +7337 BACKGROUND +7338 BACKGROUND +7339 OBJECTIVE +7340 METHODS +7341 METHODS +7342 RESULTS +7343 RESULTS +7344 RESULTS +7345 RESULTS +7346 CONCLUSIONS +7347 CONCLUSIONS +7348 BACKGROUND +7349 BACKGROUND +7350 BACKGROUND +7351 METHODS +7352 METHODS +7353 METHODS +7354 METHODS +7355 RESULTS +7356 RESULTS +7357 RESULTS +7358 RESULTS +7359 BACKGROUND +7360 BACKGROUND +7361 METHODS +7362 METHODS +7363 RESULTS +7364 METHODS +7365 METHODS +7366 METHODS +7367 METHODS +7368 METHODS +7369 RESULTS +7370 CONCLUSIONS +7371 CONCLUSIONS +7372 OBJECTIVE +7373 METHODS +7374 METHODS +7375 METHODS +7376 METHODS +7377 METHODS +7378 RESULTS +7379 RESULTS +7380 CONCLUSIONS +7381 OBJECTIVE +7382 METHODS +7383 METHODS +7384 METHODS +7385 METHODS +7386 METHODS +7387 METHODS +7388 METHODS +7389 METHODS +7390 METHODS +7391 CONCLUSIONS +7392 RESULTS +7393 RESULTS +7394 RESULTS +7395 CONCLUSIONS +7396 CONCLUSIONS +7397 CONCLUSIONS +7398 BACKGROUND +7399 METHODS +7400 METHODS +7401 METHODS +7402 RESULTS +7403 RESULTS +7404 RESULTS +7405 CONCLUSIONS +7406 CONCLUSIONS +7407 BACKGROUND +7408 BACKGROUND +7409 OBJECTIVE +7410 METHODS +7411 METHODS +7412 RESULTS +7413 RESULTS +7414 RESULTS +7415 RESULTS +7416 RESULTS +7417 RESULTS +7418 CONCLUSIONS +7419 CONCLUSIONS +7420 OBJECTIVE +7421 METHODS +7422 METHODS +7423 METHODS +7424 METHODS +7425 METHODS +7426 RESULTS +7427 RESULTS +7428 RESULTS +7429 CONCLUSIONS +7430 CONCLUSIONS +7431 CONCLUSIONS +7432 CONCLUSIONS +7433 BACKGROUND +7434 BACKGROUND +7435 METHODS +7436 METHODS +7437 METHODS +7438 RESULTS +7439 RESULTS +7440 RESULTS +7441 RESULTS +7442 RESULTS +7443 CONCLUSIONS +7444 CONCLUSIONS +7445 BACKGROUND +7446 BACKGROUND +7447 METHODS +7448 METHODS +7449 METHODS +7450 RESULTS +7451 RESULTS +7452 RESULTS +7453 METHODS +7454 RESULTS +7455 RESULTS +7456 CONCLUSIONS +7457 OBJECTIVE +7458 CONCLUSIONS +7459 OBJECTIVE +7460 RESULTS +7461 RESULTS +7462 RESULTS +7463 RESULTS +7464 OBJECTIVE +7465 BACKGROUND +7466 BACKGROUND +7467 METHODS +7468 RESULTS +7469 METHODS +7470 METHODS +7471 METHODS +7472 RESULTS +7473 RESULTS +7474 RESULTS +7475 CONCLUSIONS +7476 METHODS +7477 OBJECTIVE +7478 BACKGROUND +7479 BACKGROUND +7480 METHODS +7481 METHODS +7482 METHODS +7483 METHODS +7484 METHODS +7485 RESULTS +7486 RESULTS +7487 CONCLUSIONS +7488 BACKGROUND +7489 OBJECTIVE +7490 OBJECTIVE +7491 METHODS +7492 METHODS +7493 RESULTS +7494 RESULTS +7495 RESULTS +7496 CONCLUSIONS +7497 RESULTS +7498 OBJECTIVE +7499 METHODS +7500 METHODS +7501 METHODS +7502 METHODS +7503 METHODS +7504 RESULTS +7505 RESULTS +7506 CONCLUSIONS +7507 CONCLUSIONS +7508 OBJECTIVE +7509 METHODS +7510 METHODS +7511 METHODS +7512 METHODS +7513 METHODS +7514 METHODS +7515 METHODS +7516 METHODS +7517 METHODS +7518 RESULTS +7519 CONCLUSIONS +7520 CONCLUSIONS +7521 CONCLUSIONS +7522 CONCLUSIONS +7523 OBJECTIVE +7524 METHODS +7525 METHODS +7526 METHODS +7527 METHODS +7528 METHODS +7529 RESULTS +7530 RESULTS +7531 RESULTS +7532 RESULTS +7533 CONCLUSIONS +7534 BACKGROUND +7535 OBJECTIVE +7536 CONCLUSIONS +7537 BACKGROUND +7538 METHODS +7539 METHODS +7540 METHODS +7541 RESULTS +7542 RESULTS +7543 RESULTS +7544 RESULTS +7545 RESULTS +7546 CONCLUSIONS +7547 BACKGROUND +7548 OBJECTIVE +7549 METHODS +7550 METHODS +7551 METHODS +7552 RESULTS +7553 RESULTS +7554 RESULTS +7555 RESULTS +7556 CONCLUSIONS +7557 BACKGROUND +7558 BACKGROUND +7559 BACKGROUND +7560 BACKGROUND +7561 METHODS +7562 METHODS +7563 METHODS +7564 METHODS +7565 METHODS +7566 RESULTS +7567 RESULTS +7568 METHODS +7569 RESULTS +7570 RESULTS +7571 RESULTS +7572 RESULTS +7573 RESULTS +7574 CONCLUSIONS +7575 BACKGROUND +7576 BACKGROUND +7577 METHODS +7578 METHODS +7579 METHODS +7580 RESULTS +7581 RESULTS +7582 RESULTS +7583 RESULTS +7584 CONCLUSIONS +7585 OBJECTIVE +7586 METHODS +7587 METHODS +7588 RESULTS +7589 METHODS +7590 RESULTS +7591 RESULTS +7592 RESULTS +7593 RESULTS +7594 RESULTS +7595 RESULTS +7596 CONCLUSIONS +7597 RESULTS +7598 CONCLUSIONS +7599 RESULTS +7600 OBJECTIVE +7601 METHODS +7602 METHODS +7603 METHODS +7604 METHODS +7605 METHODS +7606 METHODS +7607 RESULTS +7608 RESULTS +7609 RESULTS +7610 RESULTS +7611 RESULTS +7612 CONCLUSIONS +7613 CONCLUSIONS +7614 OBJECTIVE +7615 METHODS +7616 METHODS +7617 METHODS +7618 METHODS +7619 METHODS +7620 RESULTS +7621 RESULTS +7622 RESULTS +7623 RESULTS +7624 RESULTS +7625 CONCLUSIONS +7626 OBJECTIVE +7627 BACKGROUND +7628 METHODS +7629 METHODS +7630 METHODS +7631 METHODS +7632 RESULTS +7633 RESULTS +7634 RESULTS +7635 RESULTS +7636 RESULTS +7637 CONCLUSIONS +7638 CONCLUSIONS +7639 OBJECTIVE +7640 METHODS +7641 METHODS +7642 METHODS +7643 METHODS +7644 METHODS +7645 METHODS +7646 METHODS +7647 RESULTS +7648 RESULTS +7649 RESULTS +7650 RESULTS +7651 RESULTS +7652 CONCLUSIONS +7653 CONCLUSIONS +7654 CONCLUSIONS +7655 BACKGROUND +7656 METHODS +7657 METHODS +7658 METHODS +7659 METHODS +7660 RESULTS +7661 METHODS +7662 RESULTS +7663 RESULTS +7664 CONCLUSIONS +7665 BACKGROUND +7666 BACKGROUND +7667 BACKGROUND +7668 OBJECTIVE +7669 METHODS +7670 METHODS +7671 METHODS +7672 METHODS +7673 METHODS +7674 METHODS +7675 RESULTS +7676 RESULTS +7677 RESULTS +7678 RESULTS +7679 CONCLUSIONS +7680 RESULTS +7681 BACKGROUND +7682 BACKGROUND +7683 METHODS +7684 METHODS +7685 METHODS +7686 METHODS +7687 METHODS +7688 METHODS +7689 RESULTS +7690 RESULTS +7691 RESULTS +7692 RESULTS +7693 RESULTS +7694 RESULTS +7695 RESULTS +7696 CONCLUSIONS +7697 CONCLUSIONS +7698 CONCLUSIONS +7699 BACKGROUND +7700 BACKGROUND +7701 METHODS +7702 METHODS +7703 METHODS +7704 RESULTS +7705 RESULTS +7706 RESULTS +7707 CONCLUSIONS +7708 BACKGROUND +7709 BACKGROUND +7710 OBJECTIVE +7711 METHODS +7712 METHODS +7713 METHODS +7714 METHODS +7715 METHODS +7716 RESULTS +7717 RESULTS +7718 RESULTS +7719 RESULTS +7720 RESULTS +7721 RESULTS +7722 RESULTS +7723 CONCLUSIONS +7724 OBJECTIVE +7725 METHODS +7726 METHODS +7727 METHODS +7728 METHODS +7729 METHODS +7730 RESULTS +7731 RESULTS +7732 CONCLUSIONS +7733 BACKGROUND +7734 BACKGROUND +7735 BACKGROUND +7736 OBJECTIVE +7737 METHODS +7738 METHODS +7739 METHODS +7740 METHODS +7741 METHODS +7742 RESULTS +7743 RESULTS +7744 RESULTS +7745 RESULTS +7746 RESULTS +7747 CONCLUSIONS +7748 CONCLUSIONS +7749 CONCLUSIONS +7750 OBJECTIVE +7751 METHODS +7752 METHODS +7753 RESULTS +7754 RESULTS +7755 RESULTS +7756 RESULTS +7757 RESULTS +7758 CONCLUSIONS +7759 BACKGROUND +7760 BACKGROUND +7761 OBJECTIVE +7762 METHODS +7763 METHODS +7764 METHODS +7765 RESULTS +7766 RESULTS +7767 CONCLUSIONS +7768 OBJECTIVE +7769 METHODS +7770 METHODS +7771 METHODS +7772 METHODS +7773 METHODS +7774 METHODS +7775 RESULTS +7776 RESULTS +7777 RESULTS +7778 RESULTS +7779 CONCLUSIONS +7780 BACKGROUND +7781 CONCLUSIONS +7782 OBJECTIVE +7783 METHODS +7784 METHODS +7785 METHODS +7786 METHODS +7787 METHODS +7788 RESULTS +7789 RESULTS +7790 RESULTS +7791 RESULTS +7792 RESULTS +7793 RESULTS +7794 CONCLUSIONS +7795 CONCLUSIONS +7796 CONCLUSIONS +7797 CONCLUSIONS +7798 BACKGROUND +7799 BACKGROUND +7800 METHODS +7801 METHODS +7802 METHODS +7803 METHODS +7804 METHODS +7805 METHODS +7806 METHODS +7807 METHODS +7808 METHODS +7809 METHODS +7810 BACKGROUND +7811 CONCLUSIONS +7812 OBJECTIVE +7813 METHODS +7814 METHODS +7815 METHODS +7816 RESULTS +7817 RESULTS +7818 RESULTS +7819 RESULTS +7820 CONCLUSIONS +7821 OBJECTIVE +7822 METHODS +7823 METHODS +7824 RESULTS +7825 RESULTS +7826 RESULTS +7827 RESULTS +7828 RESULTS +7829 CONCLUSIONS +7830 CONCLUSIONS +7831 OBJECTIVE +7832 METHODS +7833 METHODS +7834 METHODS +7835 METHODS +7836 RESULTS +7837 RESULTS +7838 RESULTS +7839 RESULTS +7840 RESULTS +7841 CONCLUSIONS +7842 RESULTS +7843 OBJECTIVE +7844 METHODS +7845 METHODS +7846 METHODS +7847 METHODS +7848 METHODS +7849 METHODS +7850 RESULTS +7851 RESULTS +7852 RESULTS +7853 RESULTS +7854 CONCLUSIONS +7855 CONCLUSIONS +7856 BACKGROUND +7857 BACKGROUND +7858 METHODS +7859 METHODS +7860 METHODS +7861 METHODS +7862 RESULTS +7863 RESULTS +7864 RESULTS +7865 RESULTS +7866 CONCLUSIONS +7867 CONCLUSIONS +7868 BACKGROUND +7869 BACKGROUND +7870 BACKGROUND +7871 BACKGROUND +7872 BACKGROUND +7873 METHODS +7874 METHODS +7875 RESULTS +7876 RESULTS +7877 RESULTS +7878 RESULTS +7879 BACKGROUND +7880 OBJECTIVE +7881 METHODS +7882 METHODS +7883 METHODS +7884 RESULTS +7885 RESULTS +7886 RESULTS +7887 RESULTS +7888 RESULTS +7889 RESULTS +7890 RESULTS +7891 CONCLUSIONS +7892 CONCLUSIONS +7893 OBJECTIVE +7894 METHODS +7895 RESULTS +7896 RESULTS +7897 RESULTS +7898 RESULTS +7899 RESULTS +7900 CONCLUSIONS +7901 CONCLUSIONS +7902 BACKGROUND +7903 OBJECTIVE +7904 METHODS +7905 RESULTS +7906 METHODS +7907 METHODS +7908 METHODS +7909 RESULTS +7910 RESULTS +7911 RESULTS +7912 RESULTS +7913 CONCLUSIONS +7914 CONCLUSIONS +7915 OBJECTIVE +7916 METHODS +7917 METHODS +7918 METHODS +7919 RESULTS +7920 RESULTS +7921 RESULTS +7922 RESULTS +7923 RESULTS +7924 CONCLUSIONS +7925 CONCLUSIONS +7926 OBJECTIVE +7927 METHODS +7928 METHODS +7929 METHODS +7930 METHODS +7931 RESULTS +7932 RESULTS +7933 RESULTS +7934 RESULTS +7935 RESULTS +7936 CONCLUSIONS +7937 CONCLUSIONS +7938 BACKGROUND +7939 CONCLUSIONS +7940 METHODS +7941 RESULTS +7942 METHODS +7943 RESULTS +7944 RESULTS +7945 CONCLUSIONS +7946 CONCLUSIONS +7947 METHODS +7948 METHODS +7949 METHODS +7950 RESULTS +7951 RESULTS +7952 RESULTS +7953 RESULTS +7954 CONCLUSIONS +7955 BACKGROUND +7956 BACKGROUND +7957 OBJECTIVE +7958 METHODS +7959 METHODS +7960 METHODS +7961 METHODS +7962 RESULTS +7963 RESULTS +7964 RESULTS +7965 CONCLUSIONS +7966 CONCLUSIONS +7967 BACKGROUND +7968 BACKGROUND +7969 BACKGROUND +7970 BACKGROUND +7971 METHODS +7972 METHODS +7973 METHODS +7974 METHODS +7975 METHODS +7976 METHODS +7977 METHODS +7978 METHODS +7979 METHODS +7980 CONCLUSIONS +7981 CONCLUSIONS +7982 CONCLUSIONS +7983 BACKGROUND +7984 OBJECTIVE +7985 METHODS +7986 METHODS +7987 METHODS +7988 RESULTS +7989 RESULTS +7990 RESULTS +7991 RESULTS +7992 RESULTS +7993 CONCLUSIONS +7994 CONCLUSIONS +7995 BACKGROUND +7996 METHODS +7997 BACKGROUND +7998 RESULTS +7999 RESULTS +8000 RESULTS +8001 RESULTS +8002 CONCLUSIONS +8003 CONCLUSIONS +8004 CONCLUSIONS +8005 OBJECTIVE +8006 METHODS +8007 METHODS +8008 METHODS +8009 METHODS +8010 RESULTS +8011 RESULTS +8012 RESULTS +8013 RESULTS +8014 RESULTS +8015 CONCLUSIONS +8016 RESULTS +8017 CONCLUSIONS +8018 BACKGROUND +8019 BACKGROUND +8020 BACKGROUND +8021 METHODS +8022 METHODS +8023 METHODS +8024 RESULTS +8025 RESULTS +8026 RESULTS +8027 RESULTS +8028 RESULTS +8029 RESULTS +8030 CONCLUSIONS +8031 CONCLUSIONS +8032 OBJECTIVE +8033 BACKGROUND +8034 BACKGROUND +8035 OBJECTIVE +8036 METHODS +8037 METHODS +8038 METHODS +8039 METHODS +8040 RESULTS +8041 RESULTS +8042 RESULTS +8043 RESULTS +8044 CONCLUSIONS +8045 OBJECTIVE +8046 OBJECTIVE +8047 METHODS +8048 METHODS +8049 METHODS +8050 METHODS +8051 METHODS +8052 RESULTS +8053 RESULTS +8054 RESULTS +8055 RESULTS +8056 RESULTS +8057 RESULTS +8058 CONCLUSIONS +8059 CONCLUSIONS +8060 BACKGROUND +8061 METHODS +8062 METHODS +8063 METHODS +8064 RESULTS +8065 RESULTS +8066 RESULTS +8067 RESULTS +8068 CONCLUSIONS +8069 CONCLUSIONS +8070 BACKGROUND +8071 BACKGROUND +8072 BACKGROUND +8073 METHODS +8074 METHODS +8075 METHODS +8076 METHODS +8077 RESULTS +8078 RESULTS +8079 RESULTS +8080 CONCLUSIONS +8081 BACKGROUND +8082 OBJECTIVE +8083 METHODS +8084 METHODS +8085 METHODS +8086 RESULTS +8087 RESULTS +8088 RESULTS +8089 RESULTS +8090 RESULTS +8091 CONCLUSIONS +8092 CONCLUSIONS +8093 OBJECTIVE +8094 METHODS +8095 METHODS +8096 METHODS +8097 METHODS +8098 METHODS +8099 RESULTS +8100 RESULTS +8101 CONCLUSIONS +8102 CONCLUSIONS +8103 BACKGROUND +8104 BACKGROUND +8105 OBJECTIVE +8106 METHODS +8107 METHODS +8108 RESULTS +8109 RESULTS +8110 RESULTS +8111 CONCLUSIONS +8112 BACKGROUND +8113 OBJECTIVE +8114 METHODS +8115 METHODS +8116 METHODS +8117 RESULTS +8118 RESULTS +8119 RESULTS +8120 RESULTS +8121 CONCLUSIONS +8122 RESULTS +8123 RESULTS +8124 OBJECTIVE +8125 METHODS +8126 METHODS +8127 METHODS +8128 METHODS +8129 METHODS +8130 METHODS +8131 METHODS +8132 METHODS +8133 RESULTS +8134 RESULTS +8135 RESULTS +8136 RESULTS +8137 CONCLUSIONS +8138 CONCLUSIONS +8139 BACKGROUND +8140 BACKGROUND +8141 OBJECTIVE +8142 METHODS +8143 METHODS +8144 METHODS +8145 METHODS +8146 RESULTS +8147 RESULTS +8148 CONCLUSIONS +8149 CONCLUSIONS +8150 BACKGROUND +8151 BACKGROUND +8152 METHODS +8153 METHODS +8154 METHODS +8155 METHODS +8156 RESULTS +8157 RESULTS +8158 RESULTS +8159 RESULTS +8160 CONCLUSIONS +8161 BACKGROUND +8162 RESULTS +8163 RESULTS +8164 BACKGROUND +8165 METHODS +8166 RESULTS +8167 METHODS +8168 RESULTS +8169 RESULTS +8170 RESULTS +8171 RESULTS +8172 RESULTS +8173 CONCLUSIONS +8174 CONCLUSIONS +8175 BACKGROUND +8176 OBJECTIVE +8177 METHODS +8178 METHODS +8179 METHODS +8180 RESULTS +8181 RESULTS +8182 RESULTS +8183 RESULTS +8184 RESULTS +8185 CONCLUSIONS +8186 OBJECTIVE +8187 METHODS +8188 METHODS +8189 METHODS +8190 METHODS +8191 RESULTS +8192 RESULTS +8193 RESULTS +8194 RESULTS +8195 CONCLUSIONS +8196 CONCLUSIONS +8197 OBJECTIVE +8198 METHODS +8199 METHODS +8200 METHODS +8201 METHODS +8202 METHODS +8203 METHODS +8204 RESULTS +8205 RESULTS +8206 RESULTS +8207 CONCLUSIONS +8208 OBJECTIVE +8209 METHODS +8210 METHODS +8211 RESULTS +8212 RESULTS +8213 CONCLUSIONS +8214 OBJECTIVE +8215 METHODS +8216 METHODS +8217 METHODS +8218 RESULTS +8219 RESULTS +8220 RESULTS +8221 CONCLUSIONS +8222 BACKGROUND +8223 METHODS +8224 METHODS +8225 METHODS +8226 METHODS +8227 METHODS +8228 RESULTS +8229 RESULTS +8230 RESULTS +8231 RESULTS +8232 CONCLUSIONS +8233 BACKGROUND +8234 BACKGROUND +8235 OBJECTIVE +8236 BACKGROUND +8237 METHODS +8238 RESULTS +8239 RESULTS +8240 RESULTS +8241 RESULTS +8242 RESULTS +8243 RESULTS +8244 RESULTS +8245 CONCLUSIONS +8246 OBJECTIVE +8247 METHODS +8248 METHODS +8249 METHODS +8250 METHODS +8251 RESULTS +8252 RESULTS +8253 RESULTS +8254 RESULTS +8255 RESULTS +8256 RESULTS +8257 CONCLUSIONS +8258 RESULTS +8259 BACKGROUND +8260 BACKGROUND +8261 OBJECTIVE +8262 METHODS +8263 METHODS +8264 METHODS +8265 METHODS +8266 METHODS +8267 OBJECTIVE +8268 METHODS +8269 METHODS +8270 METHODS +8271 METHODS +8272 METHODS +8273 METHODS +8274 METHODS +8275 RESULTS +8276 RESULTS +8277 RESULTS +8278 CONCLUSIONS +8279 OBJECTIVE +8280 METHODS +8281 METHODS +8282 METHODS +8283 METHODS +8284 METHODS +8285 METHODS +8286 RESULTS +8287 RESULTS +8288 RESULTS +8289 CONCLUSIONS +8290 OBJECTIVE +8291 METHODS +8292 METHODS +8293 METHODS +8294 METHODS +8295 RESULTS +8296 METHODS +8297 METHODS +8298 RESULTS +8299 RESULTS +8300 RESULTS +8301 RESULTS +8302 CONCLUSIONS +8303 OBJECTIVE +8304 METHODS +8305 RESULTS +8306 RESULTS +8307 RESULTS +8308 RESULTS +8309 RESULTS +8310 RESULTS +8311 RESULTS +8312 RESULTS +8313 CONCLUSIONS +8314 OBJECTIVE +8315 METHODS +8316 METHODS +8317 METHODS +8318 METHODS +8319 METHODS +8320 METHODS +8321 RESULTS +8322 RESULTS +8323 RESULTS +8324 CONCLUSIONS +8325 RESULTS +8326 RESULTS +8327 BACKGROUND +8328 CONCLUSIONS +8329 OBJECTIVE +8330 METHODS +8331 METHODS +8332 METHODS +8333 METHODS +8334 METHODS +8335 RESULTS +8336 RESULTS +8337 RESULTS +8338 CONCLUSIONS +8339 BACKGROUND +8340 BACKGROUND +8341 OBJECTIVE +8342 METHODS +8343 METHODS +8344 METHODS +8345 METHODS +8346 RESULTS +8347 RESULTS +8348 RESULTS +8349 RESULTS +8350 RESULTS +8351 CONCLUSIONS +8352 CONCLUSIONS +8353 OBJECTIVE +8354 METHODS +8355 METHODS +8356 METHODS +8357 METHODS +8358 METHODS +8359 METHODS +8360 METHODS +8361 RESULTS +8362 RESULTS +8363 RESULTS +8364 CONCLUSIONS +8365 CONCLUSIONS +8366 BACKGROUND +8367 BACKGROUND +8368 OBJECTIVE +8369 METHODS +8370 METHODS +8371 METHODS +8372 METHODS +8373 RESULTS +8374 RESULTS +8375 RESULTS +8376 RESULTS +8377 CONCLUSIONS +8378 CONCLUSIONS +8379 CONCLUSIONS +8380 BACKGROUND +8381 BACKGROUND +8382 OBJECTIVE +8383 METHODS +8384 METHODS +8385 METHODS +8386 RESULTS +8387 RESULTS +8388 RESULTS +8389 CONCLUSIONS +8390 CONCLUSIONS +8391 OBJECTIVE +8392 METHODS +8393 METHODS +8394 METHODS +8395 METHODS +8396 METHODS +8397 METHODS +8398 RESULTS +8399 RESULTS +8400 CONCLUSIONS +8401 BACKGROUND +8402 OBJECTIVE +8403 OBJECTIVE +8404 RESULTS +8405 METHODS +8406 METHODS +8407 METHODS +8408 METHODS +8409 RESULTS +8410 RESULTS +8411 RESULTS +8412 RESULTS +8413 OBJECTIVE +8414 METHODS +8415 METHODS +8416 METHODS +8417 METHODS +8418 RESULTS +8419 RESULTS +8420 CONCLUSIONS +8421 OBJECTIVE +8422 METHODS +8423 METHODS +8424 METHODS +8425 METHODS +8426 RESULTS +8427 RESULTS +8428 RESULTS +8429 CONCLUSIONS +8430 CONCLUSIONS +8431 OBJECTIVE +8432 METHODS +8433 METHODS +8434 METHODS +8435 METHODS +8436 METHODS +8437 RESULTS +8438 RESULTS +8439 RESULTS +8440 RESULTS +8441 RESULTS +8442 RESULTS +8443 RESULTS +8444 RESULTS +8445 BACKGROUND +8446 CONCLUSIONS +8447 OBJECTIVE +8448 CONCLUSIONS +8449 OBJECTIVE +8450 METHODS +8451 METHODS +8452 METHODS +8453 METHODS +8454 METHODS +8455 METHODS +8456 RESULTS +8457 RESULTS +8458 RESULTS +8459 CONCLUSIONS +8460 BACKGROUND +8461 BACKGROUND +8462 OBJECTIVE +8463 METHODS +8464 METHODS +8465 METHODS +8466 METHODS +8467 RESULTS +8468 RESULTS +8469 RESULTS +8470 RESULTS +8471 CONCLUSIONS +8472 BACKGROUND +8473 BACKGROUND +8474 METHODS +8475 METHODS +8476 RESULTS +8477 RESULTS +8478 RESULTS +8479 RESULTS +8480 RESULTS +8481 BACKGROUND +8482 BACKGROUND +8483 BACKGROUND +8484 CONCLUSIONS +8485 OBJECTIVE +8486 METHODS +8487 METHODS +8488 METHODS +8489 METHODS +8490 RESULTS +8491 RESULTS +8492 RESULTS +8493 RESULTS +8494 CONCLUSIONS +8495 OBJECTIVE +8496 METHODS +8497 METHODS +8498 METHODS +8499 METHODS +8500 METHODS +8501 METHODS +8502 METHODS +8503 RESULTS +8504 METHODS +8505 RESULTS +8506 RESULTS +8507 RESULTS +8508 CONCLUSIONS +8509 CONCLUSIONS +8510 CONCLUSIONS +8511 OBJECTIVE +8512 METHODS +8513 METHODS +8514 RESULTS +8515 RESULTS +8516 RESULTS +8517 CONCLUSIONS +8518 BACKGROUND +8519 CONCLUSIONS +8520 BACKGROUND +8521 METHODS +8522 RESULTS +8523 RESULTS +8524 RESULTS +8525 RESULTS +8526 RESULTS +8527 RESULTS +8528 RESULTS +8529 CONCLUSIONS +8530 OBJECTIVE +8531 METHODS +8532 METHODS +8533 METHODS +8534 METHODS +8535 METHODS +8536 METHODS +8537 CONCLUSIONS +8538 CONCLUSIONS +8539 CONCLUSIONS +8540 CONCLUSIONS +8541 OBJECTIVE +8542 METHODS +8543 METHODS +8544 METHODS +8545 RESULTS +8546 CONCLUSIONS +8547 RESULTS +8548 RESULTS +8549 CONCLUSIONS +8550 BACKGROUND +8551 METHODS +8552 METHODS +8553 RESULTS +8554 RESULTS +8555 RESULTS +8556 RESULTS +8557 CONCLUSIONS +8558 OBJECTIVE +8559 BACKGROUND +8560 METHODS +8561 METHODS +8562 METHODS +8563 METHODS +8564 METHODS +8565 METHODS +8566 RESULTS +8567 RESULTS +8568 RESULTS +8569 CONCLUSIONS +8570 CONCLUSIONS +8571 BACKGROUND +8572 OBJECTIVE +8573 METHODS +8574 METHODS +8575 METHODS +8576 METHODS +8577 METHODS +8578 RESULTS +8579 RESULTS +8580 RESULTS +8581 RESULTS +8582 CONCLUSIONS +8583 CONCLUSIONS +8584 OBJECTIVE +8585 BACKGROUND +8586 RESULTS +8587 METHODS +8588 RESULTS +8589 RESULTS +8590 CONCLUSIONS +8591 CONCLUSIONS +8592 BACKGROUND +8593 BACKGROUND +8594 METHODS +8595 METHODS +8596 METHODS +8597 METHODS +8598 RESULTS +8599 RESULTS +8600 RESULTS +8601 CONCLUSIONS +8602 BACKGROUND +8603 BACKGROUND +8604 METHODS +8605 METHODS +8606 METHODS +8607 METHODS +8608 RESULTS +8609 CONCLUSIONS +8610 OBJECTIVE +8611 METHODS +8612 METHODS +8613 METHODS +8614 METHODS +8615 METHODS +8616 RESULTS +8617 RESULTS +8618 RESULTS +8619 RESULTS +8620 RESULTS +8621 CONCLUSIONS +8622 CONCLUSIONS +8623 CONCLUSIONS +8624 OBJECTIVE +8625 METHODS +8626 METHODS +8627 METHODS +8628 RESULTS +8629 CONCLUSIONS +8630 CONCLUSIONS +8631 OBJECTIVE +8632 METHODS +8633 METHODS +8634 METHODS +8635 METHODS +8636 METHODS +8637 METHODS +8638 CONCLUSIONS +8639 METHODS +8640 METHODS +8641 METHODS +8642 METHODS +8643 METHODS +8644 RESULTS +8645 RESULTS +8646 CONCLUSIONS +8647 BACKGROUND +8648 BACKGROUND +8649 OBJECTIVE +8650 METHODS +8651 METHODS +8652 METHODS +8653 METHODS +8654 METHODS +8655 RESULTS +8656 RESULTS +8657 RESULTS +8658 BACKGROUND +8659 BACKGROUND +8660 METHODS +8661 RESULTS +8662 RESULTS +8663 CONCLUSIONS +8664 OBJECTIVE +8665 METHODS +8666 METHODS +8667 RESULTS +8668 RESULTS +8669 RESULTS +8670 CONCLUSIONS +8671 CONCLUSIONS +8672 BACKGROUND +8673 OBJECTIVE +8674 BACKGROUND +8675 OBJECTIVE +8676 METHODS +8677 METHODS +8678 METHODS +8679 METHODS +8680 RESULTS +8681 CONCLUSIONS +8682 RESULTS +8683 RESULTS +8684 RESULTS +8685 RESULTS +8686 RESULTS +8687 RESULTS +8688 CONCLUSIONS +8689 CONCLUSIONS +8690 BACKGROUND +8691 BACKGROUND +8692 METHODS +8693 METHODS +8694 METHODS +8695 METHODS +8696 METHODS +8697 RESULTS +8698 RESULTS +8699 RESULTS +8700 RESULTS +8701 RESULTS +8702 CONCLUSIONS +8703 BACKGROUND +8704 BACKGROUND +8705 BACKGROUND +8706 OBJECTIVE +8707 METHODS +8708 METHODS +8709 METHODS +8710 METHODS +8711 METHODS +8712 METHODS +8713 METHODS +8714 METHODS +8715 RESULTS +8716 RESULTS +8717 RESULTS +8718 CONCLUSIONS +8719 CONCLUSIONS +8720 BACKGROUND +8721 BACKGROUND +8722 BACKGROUND +8723 METHODS +8724 METHODS +8725 METHODS +8726 METHODS +8727 METHODS +8728 METHODS +8729 METHODS +8730 RESULTS +8731 RESULTS +8732 RESULTS +8733 RESULTS +8734 RESULTS +8735 RESULTS +8736 CONCLUSIONS +8737 CONCLUSIONS +8738 BACKGROUND +8739 BACKGROUND +8740 BACKGROUND +8741 METHODS +8742 METHODS +8743 METHODS +8744 RESULTS +8745 RESULTS +8746 RESULTS +8747 RESULTS +8748 CONCLUSIONS +8749 BACKGROUND +8750 OBJECTIVE +8751 METHODS +8752 METHODS +8753 METHODS +8754 RESULTS +8755 RESULTS +8756 RESULTS +8757 RESULTS +8758 RESULTS +8759 CONCLUSIONS +8760 OBJECTIVE +8761 METHODS +8762 METHODS +8763 RESULTS +8764 RESULTS +8765 RESULTS +8766 CONCLUSIONS +8767 RESULTS +8768 CONCLUSIONS +8769 OBJECTIVE +8770 METHODS +8771 METHODS +8772 RESULTS +8773 RESULTS +8774 RESULTS +8775 RESULTS +8776 CONCLUSIONS +8777 CONCLUSIONS +8778 BACKGROUND +8779 CONCLUSIONS +8780 METHODS +8781 METHODS +8782 METHODS +8783 RESULTS +8784 RESULTS +8785 CONCLUSIONS +8786 OBJECTIVE +8787 METHODS +8788 METHODS +8789 METHODS +8790 METHODS +8791 METHODS +8792 METHODS +8793 METHODS +8794 RESULTS +8795 RESULTS +8796 CONCLUSIONS +8797 CONCLUSIONS +8798 BACKGROUND +8799 OBJECTIVE +8800 METHODS +8801 METHODS +8802 METHODS +8803 RESULTS +8804 RESULTS +8805 CONCLUSIONS +8806 OBJECTIVE +8807 METHODS +8808 METHODS +8809 RESULTS +8810 RESULTS +8811 RESULTS +8812 RESULTS +8813 RESULTS +8814 CONCLUSIONS +8815 BACKGROUND +8816 OBJECTIVE +8817 OBJECTIVE +8818 METHODS +8819 METHODS +8820 METHODS +8821 METHODS +8822 METHODS +8823 RESULTS +8824 RESULTS +8825 RESULTS +8826 RESULTS +8827 CONCLUSIONS +8828 CONCLUSIONS +8829 BACKGROUND +8830 BACKGROUND +8831 BACKGROUND +8832 OBJECTIVE +8833 METHODS +8834 METHODS +8835 METHODS +8836 METHODS +8837 METHODS +8838 CONCLUSIONS +8839 BACKGROUND +8840 BACKGROUND +8841 BACKGROUND +8842 OBJECTIVE +8843 METHODS +8844 METHODS +8845 METHODS +8846 RESULTS +8847 RESULTS +8848 RESULTS +8849 CONCLUSIONS +8850 OBJECTIVE +8851 BACKGROUND +8852 METHODS +8853 METHODS +8854 RESULTS +8855 RESULTS +8856 RESULTS +8857 RESULTS +8858 CONCLUSIONS +8859 CONCLUSIONS +8860 BACKGROUND +8861 CONCLUSIONS +8862 BACKGROUND +8863 BACKGROUND +8864 BACKGROUND +8865 METHODS +8866 METHODS +8867 METHODS +8868 METHODS +8869 METHODS +8870 RESULTS +8871 METHODS +8872 RESULTS +8873 RESULTS +8874 RESULTS +8875 RESULTS +8876 CONCLUSIONS +8877 METHODS +8878 METHODS +8879 BACKGROUND +8880 BACKGROUND +8881 METHODS +8882 METHODS +8883 RESULTS +8884 RESULTS +8885 RESULTS +8886 RESULTS +8887 CONCLUSIONS +8888 CONCLUSIONS +8889 BACKGROUND +8890 BACKGROUND +8891 BACKGROUND +8892 OBJECTIVE +8893 METHODS +8894 METHODS +8895 METHODS +8896 METHODS +8897 METHODS +8898 RESULTS +8899 RESULTS +8900 CONCLUSIONS +8901 CONCLUSIONS +8902 OBJECTIVE +8903 METHODS +8904 METHODS +8905 METHODS +8906 RESULTS +8907 RESULTS +8908 RESULTS +8909 CONCLUSIONS +8910 CONCLUSIONS +8911 BACKGROUND +8912 RESULTS +8913 METHODS +8914 METHODS +8915 RESULTS +8916 RESULTS +8917 RESULTS +8918 CONCLUSIONS +8919 BACKGROUND +8920 OBJECTIVE +8921 METHODS +8922 RESULTS +8923 CONCLUSIONS +8924 OBJECTIVE +8925 METHODS +8926 METHODS +8927 METHODS +8928 METHODS +8929 RESULTS +8930 RESULTS +8931 RESULTS +8932 RESULTS +8933 CONCLUSIONS +8934 BACKGROUND +8935 BACKGROUND +8936 CONCLUSIONS +8937 BACKGROUND +8938 METHODS +8939 METHODS +8940 METHODS +8941 RESULTS +8942 RESULTS +8943 CONCLUSIONS +8944 BACKGROUND +8945 OBJECTIVE +8946 METHODS +8947 METHODS +8948 METHODS +8949 METHODS +8950 METHODS +8951 RESULTS +8952 RESULTS +8953 RESULTS +8954 CONCLUSIONS +8955 BACKGROUND +8956 OBJECTIVE +8957 METHODS +8958 METHODS +8959 METHODS +8960 RESULTS +8961 RESULTS +8962 RESULTS +8963 RESULTS +8964 RESULTS +8965 CONCLUSIONS +8966 RESULTS +8967 RESULTS +8968 OBJECTIVE +8969 METHODS +8970 METHODS +8971 METHODS +8972 METHODS +8973 METHODS +8974 METHODS +8975 RESULTS +8976 RESULTS +8977 RESULTS +8978 RESULTS +8979 CONCLUSIONS +8980 OBJECTIVE +8981 METHODS +8982 METHODS +8983 METHODS +8984 METHODS +8985 METHODS +8986 METHODS +8987 RESULTS +8988 RESULTS +8989 RESULTS +8990 CONCLUSIONS +8991 BACKGROUND +8992 CONCLUSIONS +8993 BACKGROUND +8994 METHODS +8995 METHODS +8996 RESULTS +8997 RESULTS +8998 CONCLUSIONS +8999 OBJECTIVE +9000 METHODS +9001 METHODS +9002 METHODS +9003 METHODS +9004 RESULTS +9005 RESULTS +9006 RESULTS +9007 CONCLUSIONS +9008 CONCLUSIONS +9009 CONCLUSIONS +9010 BACKGROUND +9011 BACKGROUND +9012 BACKGROUND +9013 BACKGROUND +9014 BACKGROUND +9015 METHODS +9016 METHODS +9017 RESULTS +9018 RESULTS +9019 RESULTS +9020 RESULTS +9021 RESULTS +9022 RESULTS +9023 CONCLUSIONS +9024 OBJECTIVE +9025 METHODS +9026 METHODS +9027 METHODS +9028 METHODS +9029 METHODS +9030 METHODS +9031 METHODS +9032 METHODS +9033 RESULTS +9034 RESULTS +9035 RESULTS +9036 RESULTS +9037 RESULTS +9038 RESULTS +9039 RESULTS +9040 OBJECTIVE +9041 METHODS +9042 METHODS +9043 RESULTS +9044 RESULTS +9045 RESULTS +9046 CONCLUSIONS +9047 CONCLUSIONS +9048 OBJECTIVE +9049 METHODS +9050 METHODS +9051 METHODS +9052 METHODS +9053 METHODS +9054 METHODS +9055 RESULTS +9056 RESULTS +9057 RESULTS +9058 CONCLUSIONS +9059 BACKGROUND +9060 BACKGROUND +9061 METHODS +9062 RESULTS +9063 METHODS +9064 METHODS +9065 METHODS +9066 RESULTS +9067 RESULTS +9068 CONCLUSIONS +9069 BACKGROUND +9070 OBJECTIVE +9071 METHODS +9072 METHODS +9073 METHODS +9074 METHODS +9075 METHODS +9076 RESULTS +9077 METHODS +9078 RESULTS +9079 CONCLUSIONS +9080 RESULTS +9081 CONCLUSIONS +9082 OBJECTIVE +9083 METHODS +9084 METHODS +9085 METHODS +9086 METHODS +9087 METHODS +9088 METHODS +9089 METHODS +9090 METHODS +9091 RESULTS +9092 RESULTS +9093 CONCLUSIONS +9094 CONCLUSIONS +9095 BACKGROUND +9096 OBJECTIVE +9097 METHODS +9098 METHODS +9099 METHODS +9100 METHODS +9101 RESULTS +9102 RESULTS +9103 RESULTS +9104 RESULTS +9105 RESULTS +9106 CONCLUSIONS +9107 CONCLUSIONS +9108 CONCLUSIONS +9109 METHODS +9110 METHODS +9111 METHODS +9112 METHODS +9113 METHODS +9114 OBJECTIVE +9115 RESULTS +9116 RESULTS +9117 RESULTS +9118 RESULTS +9119 CONCLUSIONS +9120 CONCLUSIONS +9121 BACKGROUND +9122 OBJECTIVE +9123 METHODS +9124 METHODS +9125 METHODS +9126 RESULTS +9127 RESULTS +9128 RESULTS +9129 CONCLUSIONS +9130 OBJECTIVE +9131 METHODS +9132 METHODS +9133 METHODS +9134 METHODS +9135 METHODS +9136 METHODS +9137 METHODS +9138 RESULTS +9139 RESULTS +9140 RESULTS +9141 CONCLUSIONS +9142 BACKGROUND +9143 BACKGROUND +9144 METHODS +9145 METHODS +9146 RESULTS +9147 METHODS +9148 METHODS +9149 METHODS +9150 METHODS +9151 RESULTS +9152 RESULTS +9153 RESULTS +9154 RESULTS +9155 RESULTS +9156 RESULTS +9157 CONCLUSIONS +9158 CONCLUSIONS +9159 OBJECTIVE +9160 METHODS +9161 RESULTS +9162 RESULTS +9163 RESULTS +9164 RESULTS +9165 RESULTS +9166 RESULTS +9167 CONCLUSIONS +9168 METHODS +9169 METHODS +9170 METHODS +9171 METHODS +9172 RESULTS +9173 RESULTS +9174 RESULTS +9175 RESULTS +9176 RESULTS +9177 RESULTS +9178 RESULTS +9179 CONCLUSIONS +9180 BACKGROUND +9181 METHODS +9182 METHODS +9183 METHODS +9184 RESULTS +9185 RESULTS +9186 RESULTS +9187 RESULTS +9188 RESULTS +9189 RESULTS +9190 RESULTS +9191 RESULTS +9192 BACKGROUND +9193 OBJECTIVE +9194 BACKGROUND +9195 BACKGROUND +9196 METHODS +9197 METHODS +9198 METHODS +9199 RESULTS +9200 RESULTS +9201 RESULTS +9202 CONCLUSIONS +9203 CONCLUSIONS +9204 OBJECTIVE +9205 METHODS +9206 METHODS +9207 METHODS +9208 METHODS +9209 METHODS +9210 METHODS +9211 RESULTS +9212 RESULTS +9213 RESULTS +9214 RESULTS +9215 CONCLUSIONS +9216 BACKGROUND +9217 OBJECTIVE +9218 METHODS +9219 METHODS +9220 METHODS +9221 METHODS +9222 RESULTS +9223 RESULTS +9224 RESULTS +9225 RESULTS +9226 RESULTS +9227 RESULTS +9228 CONCLUSIONS +9229 CONCLUSIONS +9230 CONCLUSIONS +9231 OBJECTIVE +9232 METHODS +9233 RESULTS +9234 METHODS +9235 METHODS +9236 METHODS +9237 METHODS +9238 METHODS +9239 METHODS +9240 METHODS +9241 METHODS +9242 METHODS +9243 METHODS +9244 METHODS +9245 METHODS +9246 RESULTS +9247 RESULTS +9248 RESULTS +9249 RESULTS +9250 CONCLUSIONS +9251 RESULTS +9252 RESULTS +9253 BACKGROUND +9254 BACKGROUND +9255 BACKGROUND +9256 METHODS +9257 METHODS +9258 METHODS +9259 METHODS +9260 METHODS +9261 RESULTS +9262 RESULTS +9263 RESULTS +9264 RESULTS +9265 RESULTS +9266 CONCLUSIONS +9267 BACKGROUND +9268 OBJECTIVE +9269 METHODS +9270 METHODS +9271 RESULTS +9272 RESULTS +9273 RESULTS +9274 RESULTS +9275 RESULTS +9276 CONCLUSIONS +9277 CONCLUSIONS +9278 OBJECTIVE +9279 OBJECTIVE +9280 OBJECTIVE +9281 METHODS +9282 METHODS +9283 METHODS +9284 RESULTS +9285 RESULTS +9286 RESULTS +9287 CONCLUSIONS +9288 CONCLUSIONS +9289 BACKGROUND +9290 OBJECTIVE +9291 METHODS +9292 METHODS +9293 METHODS +9294 METHODS +9295 RESULTS +9296 RESULTS +9297 RESULTS +9298 CONCLUSIONS +9299 CONCLUSIONS +9300 OBJECTIVE +9301 METHODS +9302 METHODS +9303 METHODS +9304 RESULTS +9305 RESULTS +9306 RESULTS +9307 RESULTS +9308 CONCLUSIONS +9309 BACKGROUND +9310 CONCLUSIONS +9311 OBJECTIVE +9312 METHODS +9313 METHODS +9314 METHODS +9315 METHODS +9316 METHODS +9317 RESULTS +9318 CONCLUSIONS +9319 CONCLUSIONS +9320 OBJECTIVE +9321 METHODS +9322 METHODS +9323 METHODS +9324 METHODS +9325 METHODS +9326 RESULTS +9327 CONCLUSIONS +9328 BACKGROUND +9329 CONCLUSIONS +9330 OBJECTIVE +9331 METHODS +9332 RESULTS +9333 RESULTS +9334 RESULTS +9335 CONCLUSIONS +9336 BACKGROUND +9337 BACKGROUND +9338 BACKGROUND +9339 BACKGROUND +9340 OBJECTIVE +9341 METHODS +9342 METHODS +9343 METHODS +9344 METHODS +9345 METHODS +9346 RESULTS +9347 RESULTS +9348 RESULTS +9349 RESULTS +9350 CONCLUSIONS +9351 CONCLUSIONS +9352 CONCLUSIONS +9353 OBJECTIVE +9354 METHODS +9355 METHODS +9356 METHODS +9357 METHODS +9358 RESULTS +9359 RESULTS +9360 RESULTS +9361 CONCLUSIONS +9362 BACKGROUND +9363 CONCLUSIONS +9364 OBJECTIVE +9365 METHODS +9366 METHODS +9367 METHODS +9368 RESULTS +9369 RESULTS +9370 RESULTS +9371 RESULTS +9372 RESULTS +9373 RESULTS +9374 RESULTS +9375 RESULTS +9376 CONCLUSIONS +9377 CONCLUSIONS +9378 BACKGROUND +9379 BACKGROUND +9380 BACKGROUND +9381 OBJECTIVE +9382 METHODS +9383 RESULTS +9384 RESULTS +9385 RESULTS +9386 CONCLUSIONS +9387 BACKGROUND +9388 BACKGROUND +9389 BACKGROUND +9390 BACKGROUND +9391 METHODS +9392 METHODS +9393 METHODS +9394 RESULTS +9395 RESULTS +9396 RESULTS +9397 RESULTS +9398 RESULTS +9399 BACKGROUND +9400 CONCLUSIONS +9401 OBJECTIVE +9402 METHODS +9403 METHODS +9404 METHODS +9405 METHODS +9406 METHODS +9407 METHODS +9408 METHODS +9409 METHODS +9410 RESULTS +9411 RESULTS +9412 RESULTS +9413 RESULTS +9414 RESULTS +9415 CONCLUSIONS +9416 OBJECTIVE +9417 METHODS +9418 METHODS +9419 RESULTS +9420 RESULTS +9421 RESULTS +9422 RESULTS +9423 CONCLUSIONS +9424 CONCLUSIONS +9425 OBJECTIVE +9426 METHODS +9427 METHODS +9428 METHODS +9429 METHODS +9430 RESULTS +9431 RESULTS +9432 RESULTS +9433 RESULTS +9434 RESULTS +9435 RESULTS +9436 CONCLUSIONS +9437 OBJECTIVE +9438 METHODS +9439 METHODS +9440 METHODS +9441 METHODS +9442 METHODS +9443 METHODS +9444 METHODS +9445 METHODS +9446 METHODS +9447 RESULTS +9448 RESULTS +9449 CONCLUSIONS +9450 OBJECTIVE +9451 METHODS +9452 METHODS +9453 METHODS +9454 RESULTS +9455 RESULTS +9456 RESULTS +9457 RESULTS +9458 CONCLUSIONS +9459 BACKGROUND +9460 BACKGROUND +9461 BACKGROUND +9462 METHODS +9463 METHODS +9464 METHODS +9465 METHODS +9466 METHODS +9467 METHODS +9468 METHODS +9469 RESULTS +9470 RESULTS +9471 RESULTS +9472 CONCLUSIONS +9473 BACKGROUND +9474 METHODS +9475 METHODS +9476 METHODS +9477 METHODS +9478 RESULTS +9479 RESULTS +9480 RESULTS +9481 RESULTS +9482 CONCLUSIONS +9483 BACKGROUND +9484 BACKGROUND +9485 OBJECTIVE +9486 METHODS +9487 OBJECTIVE +9488 METHODS +9489 RESULTS +9490 RESULTS +9491 CONCLUSIONS +9492 CONCLUSIONS +9493 CONCLUSIONS +9494 BACKGROUND +9495 OBJECTIVE +9496 METHODS +9497 METHODS +9498 METHODS +9499 CONCLUSIONS +9500 CONCLUSIONS +9501 RESULTS +9502 BACKGROUND +9503 BACKGROUND +9504 METHODS +9505 METHODS +9506 METHODS +9507 METHODS +9508 METHODS +9509 METHODS +9510 METHODS +9511 METHODS +9512 RESULTS +9513 RESULTS +9514 RESULTS +9515 RESULTS +9516 CONCLUSIONS +9517 CONCLUSIONS +9518 BACKGROUND +9519 OBJECTIVE +9520 METHODS +9521 METHODS +9522 METHODS +9523 RESULTS +9524 RESULTS +9525 RESULTS +9526 RESULTS +9527 CONCLUSIONS +9528 CONCLUSIONS +9529 BACKGROUND +9530 BACKGROUND +9531 METHODS +9532 METHODS +9533 METHODS +9534 RESULTS +9535 RESULTS +9536 RESULTS +9537 CONCLUSIONS +9538 CONCLUSIONS +9539 CONCLUSIONS +9540 BACKGROUND +9541 BACKGROUND +9542 BACKGROUND +9543 METHODS +9544 METHODS +9545 METHODS +9546 METHODS +9547 METHODS +9548 BACKGROUND +9549 CONCLUSIONS +9550 BACKGROUND +9551 BACKGROUND +9552 OBJECTIVE +9553 METHODS +9554 METHODS +9555 METHODS +9556 METHODS +9557 RESULTS +9558 RESULTS +9559 RESULTS +9560 RESULTS +9561 RESULTS +9562 CONCLUSIONS +9563 OBJECTIVE +9564 METHODS +9565 METHODS +9566 METHODS +9567 METHODS +9568 RESULTS +9569 RESULTS +9570 RESULTS +9571 RESULTS +9572 CONCLUSIONS +9573 BACKGROUND +9574 CONCLUSIONS +9575 OBJECTIVE +9576 METHODS +9577 METHODS +9578 METHODS +9579 RESULTS +9580 RESULTS +9581 RESULTS +9582 RESULTS +9583 CONCLUSIONS +9584 BACKGROUND +9585 BACKGROUND +9586 METHODS +9587 METHODS +9588 METHODS +9589 RESULTS +9590 RESULTS +9591 RESULTS +9592 RESULTS +9593 RESULTS +9594 RESULTS +9595 RESULTS +9596 BACKGROUND +9597 BACKGROUND +9598 OBJECTIVE +9599 METHODS +9600 METHODS +9601 METHODS +9602 RESULTS +9603 RESULTS +9604 RESULTS +9605 CONCLUSIONS +9606 CONCLUSIONS +9607 OBJECTIVE +9608 METHODS +9609 METHODS +9610 METHODS +9611 RESULTS +9612 RESULTS +9613 RESULTS +9614 RESULTS +9615 RESULTS +9616 CONCLUSIONS +9617 BACKGROUND +9618 BACKGROUND +9619 METHODS +9620 METHODS +9621 RESULTS +9622 RESULTS +9623 RESULTS +9624 RESULTS +9625 CONCLUSIONS +9626 CONCLUSIONS +9627 BACKGROUND +9628 BACKGROUND +9629 METHODS +9630 BACKGROUND +9631 RESULTS +9632 RESULTS +9633 CONCLUSIONS +9634 BACKGROUND +9635 CONCLUSIONS +9636 BACKGROUND +9637 METHODS +9638 RESULTS +9639 CONCLUSIONS +9640 BACKGROUND +9641 OBJECTIVE +9642 METHODS +9643 METHODS +9644 RESULTS +9645 RESULTS +9646 CONCLUSIONS +9647 RESULTS +9648 RESULTS +9649 RESULTS +9650 BACKGROUND +9651 BACKGROUND +9652 BACKGROUND +9653 OBJECTIVE +9654 METHODS +9655 METHODS +9656 METHODS +9657 RESULTS +9658 RESULTS +9659 RESULTS +9660 RESULTS +9661 RESULTS +9662 CONCLUSIONS +9663 BACKGROUND +9664 BACKGROUND +9665 BACKGROUND +9666 OBJECTIVE +9667 OBJECTIVE +9668 RESULTS +9669 RESULTS +9670 RESULTS +9671 CONCLUSIONS +9672 BACKGROUND +9673 OBJECTIVE +9674 OBJECTIVE +9675 METHODS +9676 METHODS +9677 METHODS +9678 METHODS +9679 RESULTS +9680 RESULTS +9681 RESULTS +9682 RESULTS +9683 RESULTS +9684 RESULTS +9685 CONCLUSIONS +9686 CONCLUSIONS +9687 OBJECTIVE +9688 OBJECTIVE +9689 METHODS +9690 METHODS +9691 METHODS +9692 RESULTS +9693 RESULTS +9694 RESULTS +9695 CONCLUSIONS +9696 CONCLUSIONS +9697 METHODS +9698 BACKGROUND +9699 BACKGROUND +9700 OBJECTIVE +9701 METHODS +9702 METHODS +9703 RESULTS +9704 RESULTS +9705 RESULTS +9706 RESULTS +9707 CONCLUSIONS +9708 CONCLUSIONS +9709 OBJECTIVE +9710 METHODS +9711 METHODS +9712 METHODS +9713 METHODS +9714 METHODS +9715 METHODS +9716 RESULTS +9717 RESULTS +9718 CONCLUSIONS +9719 CONCLUSIONS +9720 OBJECTIVE +9721 METHODS +9722 RESULTS +9723 METHODS +9724 METHODS +9725 RESULTS +9726 RESULTS +9727 RESULTS +9728 RESULTS +9729 RESULTS +9730 RESULTS +9731 RESULTS +9732 RESULTS +9733 RESULTS +9734 RESULTS +9735 RESULTS +9736 CONCLUSIONS +9737 OBJECTIVE +9738 METHODS +9739 METHODS +9740 RESULTS +9741 RESULTS +9742 RESULTS +9743 RESULTS +9744 CONCLUSIONS +9745 METHODS +9746 OBJECTIVE +9747 METHODS +9748 METHODS +9749 RESULTS +9750 RESULTS +9751 RESULTS +9752 RESULTS +9753 CONCLUSIONS +9754 OBJECTIVE +9755 METHODS +9756 METHODS +9757 METHODS +9758 RESULTS +9759 RESULTS +9760 CONCLUSIONS +9761 CONCLUSIONS +9762 CONCLUSIONS +9763 METHODS +9764 BACKGROUND +9765 BACKGROUND +9766 METHODS +9767 METHODS +9768 RESULTS +9769 RESULTS +9770 RESULTS +9771 RESULTS +9772 CONCLUSIONS +9773 CONCLUSIONS +9774 BACKGROUND +9775 BACKGROUND +9776 METHODS +9777 METHODS +9778 METHODS +9779 RESULTS +9780 RESULTS +9781 RESULTS +9782 RESULTS +9783 CONCLUSIONS +9784 CONCLUSIONS +9785 BACKGROUND +9786 BACKGROUND +9787 OBJECTIVE +9788 METHODS +9789 METHODS +9790 METHODS +9791 METHODS +9792 RESULTS +9793 RESULTS +9794 RESULTS +9795 RESULTS +9796 OBJECTIVE +9797 METHODS +9798 RESULTS +9799 RESULTS +9800 CONCLUSIONS +9801 CONCLUSIONS +9802 BACKGROUND +9803 BACKGROUND +9804 BACKGROUND +9805 METHODS +9806 METHODS +9807 RESULTS +9808 RESULTS +9809 RESULTS +9810 RESULTS +9811 CONCLUSIONS +9812 CONCLUSIONS +9813 BACKGROUND +9814 OBJECTIVE +9815 METHODS +9816 METHODS +9817 RESULTS +9818 RESULTS +9819 RESULTS +9820 CONCLUSIONS +9821 CONCLUSIONS +9822 BACKGROUND +9823 BACKGROUND +9824 BACKGROUND +9825 BACKGROUND +9826 OBJECTIVE +9827 METHODS +9828 METHODS +9829 METHODS +9830 RESULTS +9831 RESULTS +9832 CONCLUSIONS +9833 CONCLUSIONS +9834 BACKGROUND +9835 RESULTS +9836 OBJECTIVE +9837 METHODS +9838 METHODS +9839 METHODS +9840 METHODS +9841 METHODS +9842 RESULTS +9843 RESULTS +9844 CONCLUSIONS +9845 CONCLUSIONS +9846 CONCLUSIONS +9847 BACKGROUND +9848 OBJECTIVE +9849 METHODS +9850 METHODS +9851 METHODS +9852 RESULTS +9853 RESULTS +9854 CONCLUSIONS +9855 OBJECTIVE +9856 METHODS +9857 METHODS +9858 METHODS +9859 METHODS +9860 METHODS +9861 METHODS +9862 METHODS +9863 RESULTS +9864 RESULTS +9865 CONCLUSIONS +9866 OBJECTIVE +9867 METHODS +9868 RESULTS +9869 METHODS +9870 METHODS +9871 RESULTS +9872 RESULTS +9873 CONCLUSIONS +9874 BACKGROUND +9875 CONCLUSIONS +9876 CONCLUSIONS +9877 OBJECTIVE +9878 METHODS +9879 METHODS +9880 METHODS +9881 METHODS +9882 METHODS +9883 METHODS +9884 RESULTS +9885 RESULTS +9886 RESULTS +9887 RESULTS +9888 CONCLUSIONS +9889 CONCLUSIONS +9890 BACKGROUND +9891 BACKGROUND +9892 BACKGROUND +9893 METHODS +9894 RESULTS +9895 METHODS +9896 METHODS +9897 RESULTS +9898 RESULTS +9899 CONCLUSIONS +9900 BACKGROUND +9901 CONCLUSIONS +9902 RESULTS +9903 CONCLUSIONS +9904 METHODS +9905 METHODS +9906 RESULTS +9907 RESULTS +9908 CONCLUSIONS +9909 BACKGROUND +9910 OBJECTIVE +9911 METHODS +9912 METHODS +9913 METHODS +9914 METHODS +9915 METHODS +9916 RESULTS +9917 RESULTS +9918 CONCLUSIONS +9919 OBJECTIVE +9920 METHODS +9921 METHODS +9922 METHODS +9923 RESULTS +9924 RESULTS +9925 RESULTS +9926 RESULTS +9927 RESULTS +9928 CONCLUSIONS +9929 CONCLUSIONS +9930 OBJECTIVE +9931 METHODS +9932 METHODS +9933 METHODS +9934 METHODS +9935 METHODS +9936 METHODS +9937 METHODS +9938 RESULTS +9939 METHODS +9940 RESULTS +9941 RESULTS +9942 RESULTS +9943 RESULTS +9944 CONCLUSIONS +9945 OBJECTIVE +9946 METHODS +9947 METHODS +9948 METHODS +9949 METHODS +9950 METHODS +9951 METHODS +9952 METHODS +9953 METHODS +9954 METHODS +9955 METHODS +9956 RESULTS +9957 RESULTS +9958 RESULTS +9959 CONCLUSIONS +9960 BACKGROUND +9961 BACKGROUND +9962 CONCLUSIONS +9963 CONCLUSIONS +9964 RESULTS +9965 OBJECTIVE +9966 METHODS +9967 METHODS +9968 METHODS +9969 METHODS +9970 RESULTS +9971 RESULTS +9972 RESULTS +9973 RESULTS +9974 CONCLUSIONS +9975 RESULTS +9976 OBJECTIVE +9977 METHODS +9978 METHODS +9979 METHODS +9980 METHODS +9981 METHODS +9982 RESULTS +9983 RESULTS +9984 RESULTS +9985 RESULTS +9986 RESULTS +9987 CONCLUSIONS +9988 CONCLUSIONS +9989 CONCLUSIONS +9990 OBJECTIVE +9991 METHODS +9992 METHODS +9993 METHODS +9994 METHODS +9995 RESULTS +9996 RESULTS +9997 CONCLUSIONS +9998 RESULTS +9999 CONCLUSIONS +10000 CONCLUSIONS +10001 BACKGROUND +10002 RESULTS +10003 METHODS +10004 OBJECTIVE +10005 OBJECTIVE +10006 CONCLUSIONS +10007 CONCLUSIONS +10008 OBJECTIVE +10009 OBJECTIVE +10010 METHODS +10011 CONCLUSIONS +10012 CONCLUSIONS +10013 BACKGROUND +10014 OBJECTIVE +10015 METHODS +10016 METHODS +10017 METHODS +10018 RESULTS +10019 RESULTS +10020 RESULTS +10021 RESULTS +10022 CONCLUSIONS +10023 BACKGROUND +10024 OBJECTIVE +10025 METHODS +10026 METHODS +10027 RESULTS +10028 RESULTS +10029 RESULTS +10030 RESULTS +10031 CONCLUSIONS +10032 CONCLUSIONS +10033 BACKGROUND +10034 BACKGROUND +10035 METHODS +10036 METHODS +10037 METHODS +10038 RESULTS +10039 RESULTS +10040 RESULTS +10041 RESULTS +10042 RESULTS +10043 CONCLUSIONS +10044 CONCLUSIONS +10045 OBJECTIVE +10046 METHODS +10047 METHODS +10048 METHODS +10049 METHODS +10050 RESULTS +10051 RESULTS +10052 RESULTS +10053 RESULTS +10054 CONCLUSIONS +10055 OBJECTIVE +10056 METHODS +10057 RESULTS +10058 RESULTS +10059 RESULTS +10060 RESULTS +10061 RESULTS +10062 RESULTS +10063 RESULTS +10064 RESULTS +10065 CONCLUSIONS +10066 BACKGROUND +10067 OBJECTIVE +10068 METHODS +10069 METHODS +10070 METHODS +10071 RESULTS +10072 RESULTS +10073 RESULTS +10074 RESULTS +10075 CONCLUSIONS +10076 OBJECTIVE +10077 METHODS +10078 METHODS +10079 METHODS +10080 METHODS +10081 METHODS +10082 METHODS +10083 RESULTS +10084 RESULTS +10085 RESULTS +10086 RESULTS +10087 CONCLUSIONS +10088 CONCLUSIONS +10089 OBJECTIVE +10090 METHODS +10091 METHODS +10092 METHODS +10093 RESULTS +10094 RESULTS +10095 RESULTS +10096 RESULTS +10097 RESULTS +10098 CONCLUSIONS +10099 CONCLUSIONS +10100 BACKGROUND +10101 OBJECTIVE +10102 METHODS +10103 METHODS +10104 METHODS +10105 RESULTS +10106 RESULTS +10107 CONCLUSIONS +10108 CONCLUSIONS +10109 CONCLUSIONS +10110 CONCLUSIONS +10111 BACKGROUND +10112 BACKGROUND +10113 BACKGROUND +10114 RESULTS +10115 RESULTS +10116 RESULTS +10117 RESULTS +10118 RESULTS +10119 CONCLUSIONS +10120 BACKGROUND +10121 OBJECTIVE +10122 METHODS +10123 METHODS +10124 METHODS +10125 METHODS +10126 METHODS +10127 METHODS +10128 METHODS +10129 RESULTS +10130 RESULTS +10131 CONCLUSIONS +10132 RESULTS +10133 CONCLUSIONS +10134 BACKGROUND +10135 METHODS +10136 METHODS +10137 RESULTS +10138 RESULTS +10139 RESULTS +10140 CONCLUSIONS +10141 CONCLUSIONS +10142 OBJECTIVE +10143 METHODS +10144 METHODS +10145 RESULTS +10146 RESULTS +10147 RESULTS +10148 CONCLUSIONS +10149 BACKGROUND +10150 BACKGROUND +10151 OBJECTIVE +10152 METHODS +10153 METHODS +10154 RESULTS +10155 RESULTS +10156 RESULTS +10157 CONCLUSIONS +10158 CONCLUSIONS +10159 BACKGROUND +10160 METHODS +10161 METHODS +10162 METHODS +10163 METHODS +10164 METHODS +10165 METHODS +10166 RESULTS +10167 RESULTS +10168 RESULTS +10169 CONCLUSIONS +10170 BACKGROUND +10171 CONCLUSIONS +10172 OBJECTIVE +10173 METHODS +10174 METHODS +10175 RESULTS +10176 RESULTS +10177 CONCLUSIONS +10178 CONCLUSIONS +10179 CONCLUSIONS +10180 BACKGROUND +10181 BACKGROUND +10182 BACKGROUND +10183 BACKGROUND +10184 CONCLUSIONS +10185 METHODS +10186 METHODS +10187 METHODS +10188 METHODS +10189 METHODS +10190 METHODS +10191 RESULTS +10192 METHODS +10193 RESULTS +10194 CONCLUSIONS +10195 BACKGROUND +10196 BACKGROUND +10197 OBJECTIVE +10198 METHODS +10199 METHODS +10200 METHODS +10201 CONCLUSIONS +10202 RESULTS +10203 RESULTS +10204 RESULTS +10205 CONCLUSIONS +10206 CONCLUSIONS +10207 OBJECTIVE +10208 METHODS +10209 METHODS +10210 METHODS +10211 METHODS +10212 METHODS +10213 RESULTS +10214 RESULTS +10215 RESULTS +10216 RESULTS +10217 RESULTS +10218 RESULTS +10219 CONCLUSIONS +10220 BACKGROUND +10221 OBJECTIVE +10222 METHODS +10223 METHODS +10224 METHODS +10225 METHODS +10226 METHODS +10227 METHODS +10228 METHODS +10229 RESULTS +10230 RESULTS +10231 RESULTS +10232 RESULTS +10233 CONCLUSIONS +10234 CONCLUSIONS +10235 OBJECTIVE +10236 METHODS +10237 METHODS +10238 METHODS +10239 METHODS +10240 METHODS +10241 RESULTS +10242 RESULTS +10243 RESULTS +10244 RESULTS +10245 CONCLUSIONS +10246 CONCLUSIONS +10247 BACKGROUND +10248 OBJECTIVE +10249 METHODS +10250 METHODS +10251 METHODS +10252 METHODS +10253 METHODS +10254 METHODS +10255 METHODS +10256 METHODS +10257 METHODS +10258 RESULTS +10259 RESULTS +10260 RESULTS +10261 RESULTS +10262 RESULTS +10263 RESULTS +10264 CONCLUSIONS +10265 RESULTS +10266 CONCLUSIONS +10267 OBJECTIVE +10268 METHODS +10269 METHODS +10270 METHODS +10271 METHODS +10272 METHODS +10273 METHODS +10274 RESULTS +10275 RESULTS +10276 METHODS +10277 RESULTS +10278 RESULTS +10279 CONCLUSIONS +10280 CONCLUSIONS +10281 BACKGROUND +10282 BACKGROUND +10283 METHODS +10284 METHODS +10285 METHODS +10286 METHODS +10287 METHODS +10288 METHODS +10289 METHODS +10290 METHODS +10291 RESULTS +10292 RESULTS +10293 RESULTS +10294 CONCLUSIONS +10295 OBJECTIVE +10296 METHODS +10297 METHODS +10298 METHODS +10299 METHODS +10300 METHODS +10301 RESULTS +10302 RESULTS +10303 RESULTS +10304 RESULTS +10305 RESULTS +10306 CONCLUSIONS +10307 OBJECTIVE +10308 METHODS +10309 METHODS +10310 METHODS +10311 METHODS +10312 METHODS +10313 METHODS +10314 METHODS +10315 RESULTS +10316 RESULTS +10317 CONCLUSIONS +10318 CONCLUSIONS +10319 OBJECTIVE +10320 METHODS +10321 METHODS +10322 METHODS +10323 METHODS +10324 METHODS +10325 METHODS +10326 METHODS +10327 RESULTS +10328 RESULTS +10329 RESULTS +10330 RESULTS +10331 CONCLUSIONS +10332 CONCLUSIONS +10333 BACKGROUND +10334 BACKGROUND +10335 RESULTS +10336 BACKGROUND +10337 METHODS +10338 METHODS +10339 RESULTS +10340 RESULTS +10341 RESULTS +10342 RESULTS +10343 RESULTS +10344 CONCLUSIONS +10345 CONCLUSIONS +10346 BACKGROUND +10347 BACKGROUND +10348 OBJECTIVE +10349 METHODS +10350 METHODS +10351 METHODS +10352 METHODS +10353 METHODS +10354 RESULTS +10355 RESULTS +10356 RESULTS +10357 RESULTS +10358 RESULTS +10359 RESULTS +10360 RESULTS +10361 RESULTS +10362 CONCLUSIONS +10363 RESULTS +10364 BACKGROUND +10365 BACKGROUND +10366 OBJECTIVE +10367 METHODS +10368 METHODS +10369 METHODS +10370 METHODS +10371 RESULTS +10372 RESULTS +10373 RESULTS +10374 RESULTS +10375 RESULTS +10376 RESULTS +10377 RESULTS +10378 RESULTS +10379 CONCLUSIONS +10380 CONCLUSIONS +10381 BACKGROUND +10382 OBJECTIVE +10383 RESULTS +10384 RESULTS +10385 RESULTS +10386 RESULTS +10387 CONCLUSIONS +10388 CONCLUSIONS +10389 BACKGROUND +10390 OBJECTIVE +10391 METHODS +10392 METHODS +10393 METHODS +10394 RESULTS +10395 RESULTS +10396 RESULTS +10397 RESULTS +10398 RESULTS +10399 RESULTS +10400 CONCLUSIONS +10401 CONCLUSIONS +10402 OBJECTIVE +10403 METHODS +10404 METHODS +10405 METHODS +10406 CONCLUSIONS +10407 METHODS +10408 METHODS +10409 METHODS +10410 OBJECTIVE +10411 CONCLUSIONS +10412 CONCLUSIONS +10413 CONCLUSIONS +10414 RESULTS +10415 RESULTS +10416 CONCLUSIONS +10417 CONCLUSIONS +10418 CONCLUSIONS +10419 METHODS +10420 METHODS +10421 METHODS +10422 CONCLUSIONS +10423 RESULTS +10424 RESULTS +10425 CONCLUSIONS +10426 CONCLUSIONS +10427 OBJECTIVE +10428 METHODS +10429 METHODS +10430 RESULTS +10431 RESULTS +10432 RESULTS +10433 RESULTS +10434 RESULTS +10435 CONCLUSIONS +10436 CONCLUSIONS +10437 BACKGROUND +10438 BACKGROUND +10439 METHODS +10440 RESULTS +10441 METHODS +10442 METHODS +10443 METHODS +10444 RESULTS +10445 RESULTS +10446 RESULTS +10447 RESULTS +10448 RESULTS +10449 RESULTS +10450 CONCLUSIONS +10451 OBJECTIVE +10452 BACKGROUND +10453 OBJECTIVE +10454 METHODS +10455 METHODS +10456 METHODS +10457 METHODS +10458 METHODS +10459 RESULTS +10460 RESULTS +10461 RESULTS +10462 RESULTS +10463 RESULTS +10464 RESULTS +10465 RESULTS +10466 RESULTS +10467 RESULTS +10468 CONCLUSIONS +10469 RESULTS +10470 BACKGROUND +10471 OBJECTIVE +10472 METHODS +10473 METHODS +10474 METHODS +10475 METHODS +10476 METHODS +10477 RESULTS +10478 RESULTS +10479 RESULTS +10480 CONCLUSIONS +10481 CONCLUSIONS +10482 CONCLUSIONS +10483 METHODS +10484 OBJECTIVE +10485 BACKGROUND +10486 BACKGROUND +10487 METHODS +10488 METHODS +10489 METHODS +10490 METHODS +10491 METHODS +10492 METHODS +10493 METHODS +10494 METHODS +10495 RESULTS +10496 RESULTS +10497 RESULTS +10498 CONCLUSIONS +10499 CONCLUSIONS +10500 BACKGROUND +10501 BACKGROUND +10502 METHODS +10503 METHODS +10504 RESULTS +10505 RESULTS +10506 RESULTS +10507 RESULTS +10508 RESULTS +10509 RESULTS +10510 RESULTS +10511 CONCLUSIONS +10512 OBJECTIVE +10513 METHODS +10514 METHODS +10515 METHODS +10516 METHODS +10517 METHODS +10518 RESULTS +10519 RESULTS +10520 RESULTS +10521 RESULTS +10522 CONCLUSIONS +10523 CONCLUSIONS +10524 CONCLUSIONS +10525 BACKGROUND +10526 BACKGROUND +10527 METHODS +10528 METHODS +10529 METHODS +10530 RESULTS +10531 RESULTS +10532 RESULTS +10533 RESULTS +10534 RESULTS +10535 RESULTS +10536 CONCLUSIONS +10537 RESULTS +10538 CONCLUSIONS +10539 OBJECTIVE +10540 BACKGROUND +10541 BACKGROUND +10542 CONCLUSIONS +10543 OBJECTIVE +10544 METHODS +10545 METHODS +10546 RESULTS +10547 RESULTS +10548 CONCLUSIONS +10549 CONCLUSIONS +10550 OBJECTIVE +10551 METHODS +10552 METHODS +10553 METHODS +10554 RESULTS +10555 RESULTS +10556 CONCLUSIONS +10557 CONCLUSIONS +10558 OBJECTIVE +10559 METHODS +10560 METHODS +10561 CONCLUSIONS +10562 RESULTS +10563 CONCLUSIONS +10564 RESULTS +10565 CONCLUSIONS +10566 RESULTS +10567 CONCLUSIONS +10568 BACKGROUND +10569 BACKGROUND +10570 RESULTS +10571 METHODS +10572 RESULTS +10573 RESULTS +10574 RESULTS +10575 RESULTS +10576 RESULTS +10577 CONCLUSIONS +10578 OBJECTIVE +10579 METHODS +10580 METHODS +10581 METHODS +10582 METHODS +10583 RESULTS +10584 RESULTS +10585 RESULTS +10586 RESULTS +10587 CONCLUSIONS +10588 OBJECTIVE +10589 METHODS +10590 METHODS +10591 METHODS +10592 RESULTS +10593 CONCLUSIONS +10594 OBJECTIVE +10595 METHODS +10596 METHODS +10597 METHODS +10598 METHODS +10599 METHODS +10600 RESULTS +10601 RESULTS +10602 RESULTS +10603 RESULTS +10604 RESULTS +10605 CONCLUSIONS +10606 OBJECTIVE +10607 METHODS +10608 METHODS +10609 METHODS +10610 METHODS +10611 METHODS +10612 METHODS +10613 METHODS +10614 METHODS +10615 RESULTS +10616 RESULTS +10617 RESULTS +10618 CONCLUSIONS +10619 BACKGROUND +10620 BACKGROUND +10621 METHODS +10622 METHODS +10623 METHODS +10624 METHODS +10625 RESULTS +10626 RESULTS +10627 RESULTS +10628 RESULTS +10629 CONCLUSIONS +10630 CONCLUSIONS +10631 OBJECTIVE +10632 METHODS +10633 METHODS +10634 METHODS +10635 RESULTS +10636 CONCLUSIONS +10637 OBJECTIVE +10638 CONCLUSIONS +10639 CONCLUSIONS +10640 METHODS +10641 BACKGROUND +10642 OBJECTIVE +10643 METHODS +10644 METHODS +10645 METHODS +10646 RESULTS +10647 RESULTS +10648 CONCLUSIONS +10649 CONCLUSIONS +10650 OBJECTIVE +10651 METHODS +10652 METHODS +10653 RESULTS +10654 RESULTS +10655 RESULTS +10656 RESULTS +10657 RESULTS +10658 CONCLUSIONS +10659 BACKGROUND +10660 BACKGROUND +10661 BACKGROUND +10662 BACKGROUND +10663 BACKGROUND +10664 RESULTS +10665 RESULTS +10666 RESULTS +10667 METHODS +10668 RESULTS +10669 RESULTS +10670 RESULTS +10671 CONCLUSIONS +10672 CONCLUSIONS +10673 BACKGROUND +10674 BACKGROUND +10675 BACKGROUND +10676 OBJECTIVE +10677 METHODS +10678 METHODS +10679 METHODS +10680 RESULTS +10681 RESULTS +10682 OBJECTIVE +10683 OBJECTIVE +10684 METHODS +10685 METHODS +10686 METHODS +10687 METHODS +10688 RESULTS +10689 RESULTS +10690 RESULTS +10691 RESULTS +10692 CONCLUSIONS +10693 CONCLUSIONS +10694 METHODS +10695 BACKGROUND +10696 BACKGROUND +10697 METHODS +10698 RESULTS +10699 RESULTS +10700 RESULTS +10701 RESULTS +10702 RESULTS +10703 RESULTS +10704 CONCLUSIONS +10705 BACKGROUND +10706 BACKGROUND +10707 BACKGROUND +10708 OBJECTIVE +10709 METHODS +10710 METHODS +10711 METHODS +10712 METHODS +10713 METHODS +10714 RESULTS +10715 RESULTS +10716 RESULTS +10717 CONCLUSIONS +10718 CONCLUSIONS +10719 BACKGROUND +10720 OBJECTIVE +10721 OBJECTIVE +10722 METHODS +10723 METHODS +10724 METHODS +10725 RESULTS +10726 RESULTS +10727 RESULTS +10728 CONCLUSIONS +10729 CONCLUSIONS +10730 OBJECTIVE +10731 METHODS +10732 METHODS +10733 METHODS +10734 METHODS +10735 RESULTS +10736 RESULTS +10737 RESULTS +10738 RESULTS +10739 RESULTS +10740 CONCLUSIONS +10741 CONCLUSIONS +10742 BACKGROUND +10743 METHODS +10744 METHODS +10745 METHODS +10746 RESULTS +10747 RESULTS +10748 RESULTS +10749 RESULTS +10750 RESULTS +10751 RESULTS +10752 RESULTS +10753 CONCLUSIONS +10754 RESULTS +10755 BACKGROUND +10756 BACKGROUND +10757 BACKGROUND +10758 METHODS +10759 METHODS +10760 METHODS +10761 METHODS +10762 RESULTS +10763 RESULTS +10764 RESULTS +10765 RESULTS +10766 CONCLUSIONS +10767 CONCLUSIONS +10768 OBJECTIVE +10769 METHODS +10770 METHODS +10771 METHODS +10772 RESULTS +10773 RESULTS +10774 RESULTS +10775 RESULTS +10776 CONCLUSIONS +10777 BACKGROUND +10778 BACKGROUND +10779 METHODS +10780 METHODS +10781 RESULTS +10782 RESULTS +10783 RESULTS +10784 RESULTS +10785 CONCLUSIONS +10786 CONCLUSIONS +10787 OBJECTIVE +10788 METHODS +10789 METHODS +10790 METHODS +10791 METHODS +10792 METHODS +10793 METHODS +10794 METHODS +10795 METHODS +10796 RESULTS +10797 CONCLUSIONS +10798 RESULTS +10799 CONCLUSIONS +10800 OBJECTIVE +10801 METHODS +10802 METHODS +10803 METHODS +10804 METHODS +10805 METHODS +10806 METHODS +10807 RESULTS +10808 RESULTS +10809 CONCLUSIONS +10810 BACKGROUND +10811 BACKGROUND +10812 BACKGROUND +10813 METHODS +10814 CONCLUSIONS +10815 RESULTS +10816 RESULTS +10817 RESULTS +10818 CONCLUSIONS +10819 CONCLUSIONS +10820 BACKGROUND +10821 OBJECTIVE +10822 METHODS +10823 METHODS +10824 METHODS +10825 METHODS +10826 METHODS +10827 RESULTS +10828 RESULTS +10829 RESULTS +10830 RESULTS +10831 RESULTS +10832 CONCLUSIONS +10833 CONCLUSIONS +10834 OBJECTIVE +10835 METHODS +10836 METHODS +10837 RESULTS +10838 RESULTS +10839 RESULTS +10840 CONCLUSIONS +10841 BACKGROUND +10842 METHODS +10843 METHODS +10844 RESULTS +10845 METHODS +10846 METHODS +10847 METHODS +10848 RESULTS +10849 RESULTS +10850 RESULTS +10851 CONCLUSIONS +10852 CONCLUSIONS +10853 CONCLUSIONS +10854 BACKGROUND +10855 OBJECTIVE +10856 METHODS +10857 METHODS +10858 RESULTS +10859 RESULTS +10860 RESULTS +10861 CONCLUSIONS +10862 CONCLUSIONS +10863 OBJECTIVE +10864 BACKGROUND +10865 OBJECTIVE +10866 METHODS +10867 METHODS +10868 METHODS +10869 METHODS +10870 RESULTS +10871 RESULTS +10872 RESULTS +10873 RESULTS +10874 RESULTS +10875 RESULTS +10876 RESULTS +10877 CONCLUSIONS +10878 OBJECTIVE +10879 METHODS +10880 METHODS +10881 METHODS +10882 METHODS +10883 RESULTS +10884 RESULTS +10885 RESULTS +10886 CONCLUSIONS +10887 BACKGROUND +10888 OBJECTIVE +10889 METHODS +10890 METHODS +10891 METHODS +10892 RESULTS +10893 RESULTS +10894 RESULTS +10895 RESULTS +10896 RESULTS +10897 CONCLUSIONS +10898 OBJECTIVE +10899 METHODS +10900 METHODS +10901 METHODS +10902 METHODS +10903 METHODS +10904 RESULTS +10905 RESULTS +10906 RESULTS +10907 RESULTS +10908 RESULTS +10909 RESULTS +10910 RESULTS +10911 RESULTS +10912 BACKGROUND +10913 BACKGROUND +10914 RESULTS +10915 METHODS +10916 RESULTS +10917 RESULTS +10918 RESULTS +10919 RESULTS +10920 CONCLUSIONS +10921 CONCLUSIONS +10922 OBJECTIVE +10923 METHODS +10924 METHODS +10925 METHODS +10926 METHODS +10927 METHODS +10928 RESULTS +10929 RESULTS +10930 RESULTS +10931 RESULTS +10932 RESULTS +10933 CONCLUSIONS +10934 CONCLUSIONS +10935 BACKGROUND +10936 BACKGROUND +10937 METHODS +10938 RESULTS +10939 RESULTS +10940 RESULTS +10941 RESULTS +10942 RESULTS +10943 CONCLUSIONS +10944 CONCLUSIONS +10945 CONCLUSIONS +10946 BACKGROUND +10947 BACKGROUND +10948 METHODS +10949 METHODS +10950 METHODS +10951 METHODS +10952 METHODS +10953 METHODS +10954 METHODS +10955 METHODS +10956 METHODS +10957 METHODS +10958 METHODS +10959 BACKGROUND +10960 METHODS +10961 CONCLUSIONS +10962 BACKGROUND +10963 OBJECTIVE +10964 METHODS +10965 METHODS +10966 RESULTS +10967 RESULTS +10968 RESULTS +10969 RESULTS +10970 RESULTS +10971 RESULTS +10972 CONCLUSIONS +10973 BACKGROUND +10974 BACKGROUND +10975 OBJECTIVE +10976 METHODS +10977 METHODS +10978 METHODS +10979 METHODS +10980 METHODS +10981 METHODS +10982 RESULTS +10983 METHODS +10984 RESULTS +10985 CONCLUSIONS +10986 BACKGROUND +10987 BACKGROUND +10988 OBJECTIVE +10989 METHODS +10990 RESULTS +10991 RESULTS +10992 RESULTS +10993 RESULTS +10994 CONCLUSIONS +10995 RESULTS +10996 CONCLUSIONS +10997 RESULTS +10998 CONCLUSIONS +10999 BACKGROUND +11000 METHODS +11001 METHODS +11002 METHODS +11003 METHODS +11004 RESULTS +11005 RESULTS +11006 RESULTS +11007 RESULTS +11008 RESULTS +11009 RESULTS +11010 RESULTS +11011 CONCLUSIONS +11012 CONCLUSIONS +11013 OBJECTIVE +11014 METHODS +11015 METHODS +11016 METHODS +11017 METHODS +11018 RESULTS +11019 RESULTS +11020 RESULTS +11021 RESULTS +11022 RESULTS +11023 RESULTS +11024 RESULTS +11025 CONCLUSIONS +11026 CONCLUSIONS +11027 OBJECTIVE +11028 METHODS +11029 METHODS +11030 METHODS +11031 METHODS +11032 METHODS +11033 RESULTS +11034 RESULTS +11035 RESULTS +11036 RESULTS +11037 RESULTS +11038 CONCLUSIONS +11039 BACKGROUND +11040 BACKGROUND +11041 METHODS +11042 METHODS +11043 METHODS +11044 RESULTS +11045 CONCLUSIONS +11046 OBJECTIVE +11047 METHODS +11048 METHODS +11049 METHODS +11050 METHODS +11051 METHODS +11052 METHODS +11053 METHODS +11054 METHODS +11055 METHODS +11056 METHODS +11057 METHODS +11058 METHODS +11059 METHODS +11060 RESULTS +11061 RESULTS +11062 RESULTS +11063 RESULTS +11064 RESULTS +11065 CONCLUSIONS +11066 OBJECTIVE +11067 METHODS +11068 METHODS +11069 METHODS +11070 METHODS +11071 METHODS +11072 METHODS +11073 RESULTS +11074 RESULTS +11075 METHODS +11076 RESULTS +11077 CONCLUSIONS +11078 CONCLUSIONS +11079 OBJECTIVE +11080 METHODS +11081 METHODS +11082 RESULTS +11083 RESULTS +11084 RESULTS +11085 RESULTS +11086 CONCLUSIONS +11087 OBJECTIVE +11088 METHODS +11089 METHODS +11090 METHODS +11091 RESULTS +11092 RESULTS +11093 RESULTS +11094 RESULTS +11095 RESULTS +11096 RESULTS +11097 CONCLUSIONS +11098 RESULTS +11099 CONCLUSIONS +11100 OBJECTIVE +11101 METHODS +11102 METHODS +11103 METHODS +11104 RESULTS +11105 RESULTS +11106 CONCLUSIONS +11107 BACKGROUND +11108 BACKGROUND +11109 CONCLUSIONS +11110 CONCLUSIONS +11111 OBJECTIVE +11112 METHODS +11113 METHODS +11114 METHODS +11115 METHODS +11116 METHODS +11117 RESULTS +11118 RESULTS +11119 RESULTS +11120 CONCLUSIONS +11121 RESULTS +11122 CONCLUSIONS +11123 BACKGROUND +11124 OBJECTIVE +11125 METHODS +11126 METHODS +11127 METHODS +11128 METHODS +11129 METHODS +11130 METHODS +11131 METHODS +11132 METHODS +11133 RESULTS +11134 CONCLUSIONS +11135 OBJECTIVE +11136 CONCLUSIONS +11137 CONCLUSIONS +11138 OBJECTIVE +11139 METHODS +11140 METHODS +11141 METHODS +11142 METHODS +11143 METHODS +11144 RESULTS +11145 RESULTS +11146 RESULTS +11147 RESULTS +11148 CONCLUSIONS +11149 RESULTS +11150 CONCLUSIONS +11151 BACKGROUND +11152 BACKGROUND +11153 OBJECTIVE +11154 METHODS +11155 METHODS +11156 METHODS +11157 METHODS +11158 RESULTS +11159 RESULTS +11160 RESULTS +11161 CONCLUSIONS +11162 CONCLUSIONS +11163 BACKGROUND +11164 BACKGROUND +11165 METHODS +11166 METHODS +11167 METHODS +11168 RESULTS +11169 RESULTS +11170 RESULTS +11171 RESULTS +11172 RESULTS +11173 CONCLUSIONS +11174 RESULTS +11175 CONCLUSIONS +11176 OBJECTIVE +11177 METHODS +11178 METHODS +11179 METHODS +11180 METHODS +11181 METHODS +11182 METHODS +11183 METHODS +11184 RESULTS +11185 RESULTS +11186 RESULTS +11187 RESULTS +11188 RESULTS +11189 RESULTS +11190 CONCLUSIONS +11191 CONCLUSIONS +11192 OBJECTIVE +11193 METHODS +11194 METHODS +11195 METHODS +11196 METHODS +11197 METHODS +11198 METHODS +11199 METHODS +11200 RESULTS +11201 RESULTS +11202 RESULTS +11203 RESULTS +11204 CONCLUSIONS +11205 CONCLUSIONS +11206 OBJECTIVE +11207 METHODS +11208 METHODS +11209 METHODS +11210 METHODS +11211 METHODS +11212 RESULTS +11213 RESULTS +11214 RESULTS +11215 RESULTS +11216 CONCLUSIONS +11217 CONCLUSIONS +11218 METHODS +11219 BACKGROUND +11220 METHODS +11221 METHODS +11222 METHODS +11223 METHODS +11224 METHODS +11225 RESULTS +11226 RESULTS +11227 RESULTS +11228 RESULTS +11229 RESULTS +11230 RESULTS +11231 RESULTS +11232 BACKGROUND +11233 BACKGROUND +11234 BACKGROUND +11235 METHODS +11236 METHODS +11237 METHODS +11238 CONCLUSIONS +11239 RESULTS +11240 CONCLUSIONS +11241 RESULTS +11242 CONCLUSIONS +11243 METHODS +11244 METHODS +11245 OBJECTIVE +11246 METHODS +11247 METHODS +11248 METHODS +11249 METHODS +11250 METHODS +11251 RESULTS +11252 RESULTS +11253 RESULTS +11254 CONCLUSIONS +11255 BACKGROUND +11256 BACKGROUND +11257 BACKGROUND +11258 BACKGROUND +11259 BACKGROUND +11260 BACKGROUND +11261 CONCLUSIONS +11262 METHODS +11263 METHODS +11264 METHODS +11265 METHODS +11266 METHODS +11267 METHODS +11268 METHODS +11269 METHODS +11270 CONCLUSIONS +11271 BACKGROUND +11272 BACKGROUND +11273 BACKGROUND +11274 BACKGROUND +11275 BACKGROUND +11276 OBJECTIVE +11277 METHODS +11278 METHODS +11279 METHODS +11280 METHODS +11281 METHODS +11282 METHODS +11283 METHODS +11284 RESULTS +11285 RESULTS +11286 RESULTS +11287 RESULTS +11288 CONCLUSIONS +11289 BACKGROUND +11290 OBJECTIVE +11291 METHODS +11292 METHODS +11293 METHODS +11294 METHODS +11295 METHODS +11296 RESULTS +11297 RESULTS +11298 RESULTS +11299 RESULTS +11300 RESULTS +11301 RESULTS +11302 RESULTS +11303 CONCLUSIONS +11304 BACKGROUND +11305 BACKGROUND +11306 OBJECTIVE +11307 METHODS +11308 METHODS +11309 METHODS +11310 METHODS +11311 METHODS +11312 METHODS +11313 METHODS +11314 RESULTS +11315 RESULTS +11316 RESULTS +11317 CONCLUSIONS +11318 BACKGROUND +11319 BACKGROUND +11320 BACKGROUND +11321 METHODS +11322 RESULTS +11323 RESULTS +11324 CONCLUSIONS +11325 CONCLUSIONS +11326 BACKGROUND +11327 OBJECTIVE +11328 METHODS +11329 METHODS +11330 METHODS +11331 METHODS +11332 RESULTS +11333 RESULTS +11334 RESULTS +11335 CONCLUSIONS +11336 BACKGROUND +11337 BACKGROUND +11338 OBJECTIVE +11339 METHODS +11340 METHODS +11341 METHODS +11342 METHODS +11343 RESULTS +11344 RESULTS +11345 RESULTS +11346 CONCLUSIONS +11347 BACKGROUND +11348 METHODS +11349 METHODS +11350 METHODS +11351 RESULTS +11352 RESULTS +11353 RESULTS +11354 RESULTS +11355 CONCLUSIONS +11356 CONCLUSIONS +11357 CONCLUSIONS +11358 BACKGROUND +11359 BACKGROUND +11360 BACKGROUND +11361 METHODS +11362 METHODS +11363 METHODS +11364 METHODS +11365 METHODS +11366 METHODS +11367 RESULTS +11368 RESULTS +11369 RESULTS +11370 RESULTS +11371 RESULTS +11372 RESULTS +11373 BACKGROUND +11374 OBJECTIVE +11375 OBJECTIVE +11376 METHODS +11377 METHODS +11378 METHODS +11379 METHODS +11380 METHODS +11381 METHODS +11382 RESULTS +11383 RESULTS +11384 CONCLUSIONS +11385 BACKGROUND +11386 BACKGROUND +11387 OBJECTIVE +11388 METHODS +11389 METHODS +11390 METHODS +11391 METHODS +11392 METHODS +11393 METHODS +11394 RESULTS +11395 RESULTS +11396 CONCLUSIONS +11397 CONCLUSIONS +11398 CONCLUSIONS +11399 OBJECTIVE +11400 METHODS +11401 METHODS +11402 METHODS +11403 METHODS +11404 METHODS +11405 RESULTS +11406 RESULTS +11407 RESULTS +11408 RESULTS +11409 CONCLUSIONS +11410 BACKGROUND +11411 METHODS +11412 METHODS +11413 METHODS +11414 METHODS +11415 METHODS +11416 RESULTS +11417 RESULTS +11418 RESULTS +11419 RESULTS +11420 RESULTS +11421 RESULTS +11422 CONCLUSIONS +11423 CONCLUSIONS +11424 BACKGROUND +11425 BACKGROUND +11426 BACKGROUND +11427 BACKGROUND +11428 BACKGROUND +11429 METHODS +11430 METHODS +11431 METHODS +11432 CONCLUSIONS +11433 CONCLUSIONS +11434 BACKGROUND +11435 BACKGROUND +11436 METHODS +11437 METHODS +11438 METHODS +11439 METHODS +11440 METHODS +11441 RESULTS +11442 RESULTS +11443 RESULTS +11444 RESULTS +11445 RESULTS +11446 BACKGROUND +11447 CONCLUSIONS +11448 BACKGROUND +11449 OBJECTIVE +11450 METHODS +11451 METHODS +11452 METHODS +11453 RESULTS +11454 RESULTS +11455 RESULTS +11456 CONCLUSIONS +11457 BACKGROUND +11458 BACKGROUND +11459 BACKGROUND +11460 BACKGROUND +11461 METHODS +11462 METHODS +11463 RESULTS +11464 RESULTS +11465 RESULTS +11466 RESULTS +11467 CONCLUSIONS +11468 CONCLUSIONS +11469 CONCLUSIONS +11470 BACKGROUND +11471 BACKGROUND +11472 BACKGROUND +11473 OBJECTIVE +11474 METHODS +11475 METHODS +11476 RESULTS +11477 RESULTS +11478 RESULTS +11479 RESULTS +11480 CONCLUSIONS +11481 CONCLUSIONS +11482 OBJECTIVE +11483 METHODS +11484 METHODS +11485 METHODS +11486 RESULTS +11487 RESULTS +11488 RESULTS +11489 RESULTS +11490 CONCLUSIONS +11491 BACKGROUND +11492 BACKGROUND +11493 OBJECTIVE +11494 METHODS +11495 METHODS +11496 METHODS +11497 METHODS +11498 METHODS +11499 RESULTS +11500 RESULTS +11501 CONCLUSIONS +11502 CONCLUSIONS +11503 OBJECTIVE +11504 METHODS +11505 RESULTS +11506 RESULTS +11507 RESULTS +11508 RESULTS +11509 RESULTS +11510 RESULTS +11511 CONCLUSIONS +11512 RESULTS +11513 RESULTS +11514 OBJECTIVE +11515 BACKGROUND +11516 CONCLUSIONS +11517 OBJECTIVE +11518 METHODS +11519 METHODS +11520 METHODS +11521 METHODS +11522 METHODS +11523 RESULTS +11524 RESULTS +11525 RESULTS +11526 RESULTS +11527 RESULTS +11528 CONCLUSIONS +11529 CONCLUSIONS +11530 CONCLUSIONS +11531 OBJECTIVE +11532 METHODS +11533 METHODS +11534 METHODS +11535 METHODS +11536 RESULTS +11537 RESULTS +11538 CONCLUSIONS +11539 CONCLUSIONS +11540 OBJECTIVE +11541 OBJECTIVE +11542 OBJECTIVE +11543 OBJECTIVE +11544 METHODS +11545 METHODS +11546 METHODS +11547 RESULTS +11548 RESULTS +11549 CONCLUSIONS +11550 CONCLUSIONS +11551 CONCLUSIONS +11552 BACKGROUND +11553 OBJECTIVE +11554 OBJECTIVE +11555 METHODS +11556 METHODS +11557 RESULTS +11558 METHODS +11559 RESULTS +11560 RESULTS +11561 RESULTS +11562 RESULTS +11563 RESULTS +11564 RESULTS +11565 RESULTS +11566 RESULTS +11567 RESULTS +11568 RESULTS +11569 CONCLUSIONS +11570 CONCLUSIONS +11571 BACKGROUND +11572 METHODS +11573 METHODS +11574 METHODS +11575 METHODS +11576 RESULTS +11577 RESULTS +11578 RESULTS +11579 RESULTS +11580 RESULTS +11581 RESULTS +11582 CONCLUSIONS +11583 CONCLUSIONS +11584 CONCLUSIONS +11585 OBJECTIVE +11586 METHODS +11587 METHODS +11588 METHODS +11589 METHODS +11590 RESULTS +11591 RESULTS +11592 CONCLUSIONS +11593 CONCLUSIONS +11594 CONCLUSIONS +11595 OBJECTIVE +11596 METHODS +11597 METHODS +11598 METHODS +11599 OBJECTIVE +11600 RESULTS +11601 RESULTS +11602 RESULTS +11603 RESULTS +11604 CONCLUSIONS +11605 BACKGROUND +11606 BACKGROUND +11607 BACKGROUND +11608 METHODS +11609 METHODS +11610 METHODS +11611 RESULTS +11612 RESULTS +11613 RESULTS +11614 RESULTS +11615 BACKGROUND +11616 BACKGROUND +11617 BACKGROUND +11618 METHODS +11619 METHODS +11620 METHODS +11621 METHODS +11622 METHODS +11623 METHODS +11624 RESULTS +11625 RESULTS +11626 RESULTS +11627 CONCLUSIONS +11628 BACKGROUND +11629 BACKGROUND +11630 BACKGROUND +11631 METHODS +11632 METHODS +11633 METHODS +11634 METHODS +11635 METHODS +11636 RESULTS +11637 RESULTS +11638 RESULTS +11639 RESULTS +11640 RESULTS +11641 CONCLUSIONS +11642 BACKGROUND +11643 METHODS +11644 METHODS +11645 METHODS +11646 METHODS +11647 METHODS +11648 RESULTS +11649 RESULTS +11650 RESULTS +11651 RESULTS +11652 CONCLUSIONS +11653 BACKGROUND +11654 OBJECTIVE +11655 METHODS +11656 METHODS +11657 METHODS +11658 METHODS +11659 RESULTS +11660 RESULTS +11661 RESULTS +11662 RESULTS +11663 RESULTS +11664 RESULTS +11665 RESULTS +11666 RESULTS +11667 CONCLUSIONS +11668 CONCLUSIONS +11669 OBJECTIVE +11670 METHODS +11671 METHODS +11672 METHODS +11673 METHODS +11674 RESULTS +11675 RESULTS +11676 RESULTS +11677 RESULTS +11678 RESULTS +11679 RESULTS +11680 RESULTS +11681 RESULTS +11682 RESULTS +11683 RESULTS +11684 CONCLUSIONS +11685 CONCLUSIONS +11686 OBJECTIVE +11687 RESULTS +11688 CONCLUSIONS +11689 OBJECTIVE +11690 OBJECTIVE +11691 METHODS +11692 METHODS +11693 RESULTS +11694 RESULTS +11695 RESULTS +11696 RESULTS +11697 CONCLUSIONS +11698 OBJECTIVE +11699 METHODS +11700 METHODS +11701 METHODS +11702 METHODS +11703 METHODS +11704 RESULTS +11705 RESULTS +11706 RESULTS +11707 RESULTS +11708 CONCLUSIONS +11709 BACKGROUND +11710 BACKGROUND +11711 OBJECTIVE +11712 METHODS +11713 METHODS +11714 CONCLUSIONS +11715 CONCLUSIONS +11716 RESULTS +11717 CONCLUSIONS +11718 OBJECTIVE +11719 METHODS +11720 METHODS +11721 METHODS +11722 METHODS +11723 RESULTS +11724 RESULTS +11725 RESULTS +11726 RESULTS +11727 CONCLUSIONS +11728 CONCLUSIONS +11729 BACKGROUND +11730 BACKGROUND +11731 BACKGROUND +11732 CONCLUSIONS +11733 BACKGROUND +11734 METHODS +11735 METHODS +11736 METHODS +11737 METHODS +11738 METHODS +11739 RESULTS +11740 RESULTS +11741 CONCLUSIONS +11742 CONCLUSIONS +11743 BACKGROUND +11744 OBJECTIVE +11745 METHODS +11746 METHODS +11747 METHODS +11748 METHODS +11749 METHODS +11750 METHODS +11751 METHODS +11752 RESULTS +11753 RESULTS +11754 RESULTS +11755 METHODS +11756 RESULTS +11757 RESULTS +11758 RESULTS +11759 CONCLUSIONS +11760 OBJECTIVE +11761 OBJECTIVE +11762 METHODS +11763 METHODS +11764 METHODS +11765 METHODS +11766 RESULTS +11767 RESULTS +11768 RESULTS +11769 RESULTS +11770 CONCLUSIONS +11771 CONCLUSIONS +11772 OBJECTIVE +11773 METHODS +11774 METHODS +11775 METHODS +11776 RESULTS +11777 RESULTS +11778 RESULTS +11779 RESULTS +11780 CONCLUSIONS +11781 OBJECTIVE +11782 METHODS +11783 METHODS +11784 METHODS +11785 METHODS +11786 METHODS +11787 RESULTS +11788 RESULTS +11789 CONCLUSIONS +11790 BACKGROUND +11791 OBJECTIVE +11792 METHODS +11793 METHODS +11794 RESULTS +11795 RESULTS +11796 METHODS +11797 RESULTS +11798 RESULTS +11799 RESULTS +11800 CONCLUSIONS +11801 BACKGROUND +11802 CONCLUSIONS +11803 CONCLUSIONS +11804 BACKGROUND +11805 BACKGROUND +11806 METHODS +11807 BACKGROUND +11808 METHODS +11809 METHODS +11810 METHODS +11811 METHODS +11812 METHODS +11813 METHODS +11814 METHODS +11815 BACKGROUND +11816 CONCLUSIONS +11817 BACKGROUND +11818 BACKGROUND +11819 OBJECTIVE +11820 METHODS +11821 METHODS +11822 RESULTS +11823 RESULTS +11824 RESULTS +11825 CONCLUSIONS +11826 CONCLUSIONS +11827 OBJECTIVE +11828 METHODS +11829 METHODS +11830 METHODS +11831 METHODS +11832 RESULTS +11833 RESULTS +11834 RESULTS +11835 CONCLUSIONS +11836 BACKGROUND +11837 METHODS +11838 BACKGROUND +11839 BACKGROUND +11840 CONCLUSIONS +11841 BACKGROUND +11842 BACKGROUND +11843 BACKGROUND +11844 METHODS +11845 METHODS +11846 METHODS +11847 METHODS +11848 METHODS +11849 METHODS +11850 METHODS +11851 METHODS +11852 METHODS +11853 CONCLUSIONS +11854 BACKGROUND +11855 OBJECTIVE +11856 METHODS +11857 METHODS +11858 METHODS +11859 METHODS +11860 RESULTS +11861 RESULTS +11862 RESULTS +11863 RESULTS +11864 CONCLUSIONS +11865 CONCLUSIONS +11866 OBJECTIVE +11867 METHODS +11868 METHODS +11869 METHODS +11870 METHODS +11871 RESULTS +11872 RESULTS +11873 RESULTS +11874 RESULTS +11875 RESULTS +11876 RESULTS +11877 RESULTS +11878 OBJECTIVE +11879 METHODS +11880 METHODS +11881 METHODS +11882 METHODS +11883 METHODS +11884 METHODS +11885 METHODS +11886 METHODS +11887 RESULTS +11888 RESULTS +11889 RESULTS +11890 CONCLUSIONS +11891 CONCLUSIONS +11892 RESULTS +11893 OBJECTIVE +11894 METHODS +11895 BACKGROUND +11896 BACKGROUND +11897 METHODS +11898 RESULTS +11899 RESULTS +11900 RESULTS +11901 OBJECTIVE +11902 METHODS +11903 METHODS +11904 RESULTS +11905 RESULTS +11906 RESULTS +11907 RESULTS +11908 RESULTS +11909 RESULTS +11910 RESULTS +11911 RESULTS +11912 CONCLUSIONS +11913 OBJECTIVE +11914 METHODS +11915 METHODS +11916 METHODS +11917 METHODS +11918 RESULTS +11919 RESULTS +11920 RESULTS +11921 RESULTS +11922 RESULTS +11923 RESULTS +11924 CONCLUSIONS +11925 METHODS +11926 CONCLUSIONS +11927 BACKGROUND +11928 BACKGROUND +11929 OBJECTIVE +11930 METHODS +11931 METHODS +11932 METHODS +11933 METHODS +11934 METHODS +11935 RESULTS +11936 RESULTS +11937 RESULTS +11938 RESULTS +11939 RESULTS +11940 RESULTS +11941 RESULTS +11942 CONCLUSIONS +11943 OBJECTIVE +11944 OBJECTIVE +11945 METHODS +11946 METHODS +11947 METHODS +11948 METHODS +11949 RESULTS +11950 RESULTS +11951 CONCLUSIONS +11952 CONCLUSIONS +11953 OBJECTIVE +11954 METHODS +11955 METHODS +11956 RESULTS +11957 RESULTS +11958 RESULTS +11959 CONCLUSIONS +11960 OBJECTIVE +11961 METHODS +11962 METHODS +11963 METHODS +11964 METHODS +11965 RESULTS +11966 RESULTS +11967 CONCLUSIONS +11968 OBJECTIVE +11969 METHODS +11970 METHODS +11971 METHODS +11972 METHODS +11973 METHODS +11974 METHODS +11975 RESULTS +11976 RESULTS +11977 RESULTS +11978 CONCLUSIONS +11979 BACKGROUND +11980 OBJECTIVE +11981 OBJECTIVE +11982 METHODS +11983 METHODS +11984 METHODS +11985 METHODS +11986 RESULTS +11987 RESULTS +11988 RESULTS +11989 CONCLUSIONS +11990 CONCLUSIONS +11991 CONCLUSIONS +11992 OBJECTIVE +11993 METHODS +11994 METHODS +11995 METHODS +11996 RESULTS +11997 RESULTS +11998 RESULTS +11999 RESULTS +12000 RESULTS +12001 CONCLUSIONS +12002 CONCLUSIONS +12003 OBJECTIVE +12004 OBJECTIVE +12005 METHODS +12006 METHODS +12007 METHODS +12008 METHODS +12009 METHODS +12010 RESULTS +12011 RESULTS +12012 RESULTS +12013 RESULTS +12014 RESULTS +12015 RESULTS +12016 RESULTS +12017 CONCLUSIONS +12018 BACKGROUND +12019 METHODS +12020 METHODS +12021 METHODS +12022 METHODS +12023 RESULTS +12024 RESULTS +12025 RESULTS +12026 CONCLUSIONS +12027 BACKGROUND +12028 BACKGROUND +12029 BACKGROUND +12030 BACKGROUND +12031 OBJECTIVE +12032 METHODS +12033 METHODS +12034 METHODS +12035 RESULTS +12036 RESULTS +12037 RESULTS +12038 CONCLUSIONS +12039 OBJECTIVE +12040 METHODS +12041 METHODS +12042 METHODS +12043 RESULTS +12044 RESULTS +12045 RESULTS +12046 RESULTS +12047 RESULTS +12048 CONCLUSIONS +12049 CONCLUSIONS +12050 OBJECTIVE +12051 METHODS +12052 METHODS +12053 CONCLUSIONS +12054 RESULTS +12055 CONCLUSIONS +12056 BACKGROUND +12057 BACKGROUND +12058 BACKGROUND +12059 OBJECTIVE +12060 METHODS +12061 METHODS +12062 METHODS +12063 METHODS +12064 METHODS +12065 METHODS +12066 METHODS +12067 METHODS +12068 RESULTS +12069 RESULTS +12070 RESULTS +12071 RESULTS +12072 CONCLUSIONS +12073 CONCLUSIONS +12074 BACKGROUND +12075 METHODS +12076 METHODS +12077 METHODS +12078 METHODS +12079 RESULTS +12080 RESULTS +12081 RESULTS +12082 RESULTS +12083 BACKGROUND +12084 CONCLUSIONS +12085 BACKGROUND +12086 OBJECTIVE +12087 OBJECTIVE +12088 RESULTS +12089 RESULTS +12090 RESULTS +12091 RESULTS +12092 RESULTS +12093 CONCLUSIONS +12094 OBJECTIVE +12095 METHODS +12096 METHODS +12097 METHODS +12098 METHODS +12099 METHODS +12100 RESULTS +12101 RESULTS +12102 RESULTS +12103 RESULTS +12104 CONCLUSIONS +12105 CONCLUSIONS +12106 BACKGROUND +12107 BACKGROUND +12108 RESULTS +12109 RESULTS +12110 RESULTS +12111 RESULTS +12112 RESULTS +12113 RESULTS +12114 CONCLUSIONS +12115 CONCLUSIONS +12116 OBJECTIVE +12117 METHODS +12118 METHODS +12119 METHODS +12120 METHODS +12121 RESULTS +12122 RESULTS +12123 RESULTS +12124 CONCLUSIONS +12125 OBJECTIVE +12126 METHODS +12127 RESULTS +12128 RESULTS +12129 RESULTS +12130 RESULTS +12131 CONCLUSIONS +12132 BACKGROUND +12133 BACKGROUND +12134 BACKGROUND +12135 OBJECTIVE +12136 METHODS +12137 METHODS +12138 METHODS +12139 RESULTS +12140 RESULTS +12141 RESULTS +12142 CONCLUSIONS +12143 BACKGROUND +12144 BACKGROUND +12145 METHODS +12146 METHODS +12147 METHODS +12148 METHODS +12149 METHODS +12150 METHODS +12151 RESULTS +12152 RESULTS +12153 RESULTS +12154 CONCLUSIONS +12155 CONCLUSIONS +12156 OBJECTIVE +12157 METHODS +12158 METHODS +12159 METHODS +12160 METHODS +12161 METHODS +12162 METHODS +12163 METHODS +12164 RESULTS +12165 RESULTS +12166 RESULTS +12167 RESULTS +12168 CONCLUSIONS +12169 CONCLUSIONS +12170 OBJECTIVE +12171 METHODS +12172 METHODS +12173 RESULTS +12174 METHODS +12175 RESULTS +12176 RESULTS +12177 RESULTS +12178 CONCLUSIONS +12179 CONCLUSIONS +12180 CONCLUSIONS +12181 CONCLUSIONS +12182 OBJECTIVE +12183 METHODS +12184 METHODS +12185 METHODS +12186 METHODS +12187 RESULTS +12188 RESULTS +12189 RESULTS +12190 RESULTS +12191 CONCLUSIONS +12192 OBJECTIVE +12193 METHODS +12194 METHODS +12195 RESULTS +12196 RESULTS +12197 CONCLUSIONS +12198 BACKGROUND +12199 BACKGROUND +12200 METHODS +12201 METHODS +12202 METHODS +12203 RESULTS +12204 RESULTS +12205 RESULTS +12206 RESULTS +12207 BACKGROUND +12208 CONCLUSIONS +12209 BACKGROUND +12210 BACKGROUND +12211 BACKGROUND +12212 BACKGROUND +12213 BACKGROUND +12214 RESULTS +12215 RESULTS +12216 CONCLUSIONS +12217 BACKGROUND +12218 BACKGROUND +12219 BACKGROUND +12220 OBJECTIVE +12221 METHODS +12222 METHODS +12223 METHODS +12224 RESULTS +12225 RESULTS +12226 CONCLUSIONS +12227 BACKGROUND +12228 BACKGROUND +12229 METHODS +12230 RESULTS +12231 RESULTS +12232 RESULTS +12233 RESULTS +12234 CONCLUSIONS +12235 CONCLUSIONS +12236 OBJECTIVE +12237 METHODS +12238 METHODS +12239 METHODS +12240 RESULTS +12241 RESULTS +12242 RESULTS +12243 CONCLUSIONS +12244 CONCLUSIONS +12245 OBJECTIVE +12246 RESULTS +12247 OBJECTIVE +12248 METHODS +12249 METHODS +12250 RESULTS +12251 RESULTS +12252 RESULTS +12253 CONCLUSIONS +12254 OBJECTIVE +12255 METHODS +12256 METHODS +12257 METHODS +12258 METHODS +12259 METHODS +12260 METHODS +12261 METHODS +12262 RESULTS +12263 RESULTS +12264 RESULTS +12265 RESULTS +12266 RESULTS +12267 RESULTS +12268 CONCLUSIONS +12269 RESULTS +12270 CONCLUSIONS +12271 CONCLUSIONS +12272 CONCLUSIONS +12273 BACKGROUND +12274 OBJECTIVE +12275 METHODS +12276 METHODS +12277 RESULTS +12278 RESULTS +12279 RESULTS +12280 RESULTS +12281 RESULTS +12282 CONCLUSIONS +12283 BACKGROUND +12284 BACKGROUND +12285 OBJECTIVE +12286 METHODS +12287 METHODS +12288 RESULTS +12289 RESULTS +12290 BACKGROUND +12291 CONCLUSIONS +12292 OBJECTIVE +12293 METHODS +12294 RESULTS +12295 RESULTS +12296 RESULTS +12297 RESULTS +12298 RESULTS +12299 RESULTS +12300 CONCLUSIONS +12301 BACKGROUND +12302 OBJECTIVE +12303 BACKGROUND +12304 METHODS +12305 METHODS +12306 METHODS +12307 METHODS +12308 RESULTS +12309 RESULTS +12310 RESULTS +12311 RESULTS +12312 RESULTS +12313 RESULTS +12314 RESULTS +12315 BACKGROUND +12316 CONCLUSIONS +12317 CONCLUSIONS +12318 CONCLUSIONS +12319 OBJECTIVE +12320 METHODS +12321 METHODS +12322 METHODS +12323 METHODS +12324 METHODS +12325 RESULTS +12326 RESULTS +12327 RESULTS +12328 CONCLUSIONS +12329 CONCLUSIONS +12330 OBJECTIVE +12331 OBJECTIVE +12332 METHODS +12333 METHODS +12334 METHODS +12335 RESULTS +12336 RESULTS +12337 RESULTS +12338 RESULTS +12339 CONCLUSIONS +12340 CONCLUSIONS +12341 BACKGROUND +12342 OBJECTIVE +12343 METHODS +12344 METHODS +12345 METHODS +12346 METHODS +12347 RESULTS +12348 RESULTS +12349 RESULTS +12350 RESULTS +12351 RESULTS +12352 RESULTS +12353 RESULTS +12354 CONCLUSIONS +12355 BACKGROUND +12356 BACKGROUND +12357 BACKGROUND +12358 METHODS +12359 METHODS +12360 METHODS +12361 METHODS +12362 METHODS +12363 METHODS +12364 RESULTS +12365 RESULTS +12366 RESULTS +12367 RESULTS +12368 RESULTS +12369 CONCLUSIONS +12370 BACKGROUND +12371 BACKGROUND +12372 OBJECTIVE +12373 METHODS +12374 METHODS +12375 RESULTS +12376 RESULTS +12377 RESULTS +12378 RESULTS +12379 RESULTS +12380 RESULTS +12381 RESULTS +12382 CONCLUSIONS +12383 OBJECTIVE +12384 METHODS +12385 METHODS +12386 METHODS +12387 METHODS +12388 METHODS +12389 RESULTS +12390 RESULTS +12391 RESULTS +12392 RESULTS +12393 RESULTS +12394 RESULTS +12395 RESULTS +12396 RESULTS +12397 RESULTS +12398 RESULTS +12399 BACKGROUND +12400 RESULTS +12401 CONCLUSIONS +12402 CONCLUSIONS +12403 BACKGROUND +12404 BACKGROUND +12405 BACKGROUND +12406 BACKGROUND +12407 METHODS +12408 METHODS +12409 METHODS +12410 METHODS +12411 METHODS +12412 RESULTS +12413 RESULTS +12414 RESULTS +12415 RESULTS +12416 RESULTS +12417 RESULTS +12418 CONCLUSIONS +12419 CONCLUSIONS +12420 BACKGROUND +12421 BACKGROUND +12422 BACKGROUND +12423 OBJECTIVE +12424 METHODS +12425 METHODS +12426 RESULTS +12427 RESULTS +12428 RESULTS +12429 CONCLUSIONS +12430 RESULTS +12431 CONCLUSIONS +12432 BACKGROUND +12433 BACKGROUND +12434 METHODS +12435 METHODS +12436 RESULTS +12437 RESULTS +12438 RESULTS +12439 RESULTS +12440 RESULTS +12441 RESULTS +12442 CONCLUSIONS +12443 CONCLUSIONS +12444 OBJECTIVE +12445 METHODS +12446 METHODS +12447 METHODS +12448 METHODS +12449 RESULTS +12450 RESULTS +12451 RESULTS +12452 RESULTS +12453 CONCLUSIONS +12454 CONCLUSIONS +12455 OBJECTIVE +12456 METHODS +12457 METHODS +12458 METHODS +12459 METHODS +12460 RESULTS +12461 RESULTS +12462 RESULTS +12463 RESULTS +12464 CONCLUSIONS +12465 BACKGROUND +12466 BACKGROUND +12467 OBJECTIVE +12468 OBJECTIVE +12469 METHODS +12470 METHODS +12471 METHODS +12472 RESULTS +12473 RESULTS +12474 CONCLUSIONS +12475 OBJECTIVE +12476 BACKGROUND +12477 METHODS +12478 METHODS +12479 METHODS +12480 RESULTS +12481 RESULTS +12482 CONCLUSIONS +12483 BACKGROUND +12484 BACKGROUND +12485 OBJECTIVE +12486 METHODS +12487 METHODS +12488 METHODS +12489 METHODS +12490 CONCLUSIONS +12491 RESULTS +12492 CONCLUSIONS +12493 CONCLUSIONS +12494 RESULTS +12495 CONCLUSIONS +12496 CONCLUSIONS +12497 BACKGROUND +12498 BACKGROUND +12499 BACKGROUND +12500 METHODS +12501 METHODS +12502 METHODS +12503 METHODS +12504 METHODS +12505 RESULTS +12506 RESULTS +12507 BACKGROUND +12508 BACKGROUND +12509 BACKGROUND +12510 BACKGROUND +12511 BACKGROUND +12512 BACKGROUND +12513 BACKGROUND +12514 METHODS +12515 METHODS +12516 METHODS +12517 METHODS +12518 METHODS +12519 METHODS +12520 METHODS +12521 RESULTS +12522 RESULTS +12523 RESULTS +12524 RESULTS +12525 RESULTS +12526 CONCLUSIONS +12527 RESULTS +12528 BACKGROUND +12529 BACKGROUND +12530 BACKGROUND +12531 BACKGROUND +12532 METHODS +12533 RESULTS +12534 RESULTS +12535 RESULTS +12536 RESULTS +12537 CONCLUSIONS +12538 CONCLUSIONS +12539 BACKGROUND +12540 OBJECTIVE +12541 OBJECTIVE +12542 METHODS +12543 METHODS +12544 METHODS +12545 RESULTS +12546 CONCLUSIONS +12547 CONCLUSIONS +12548 CONCLUSIONS +12549 CONCLUSIONS +12550 BACKGROUND +12551 METHODS +12552 METHODS +12553 METHODS +12554 RESULTS +12555 RESULTS +12556 RESULTS +12557 RESULTS +12558 RESULTS +12559 RESULTS +12560 CONCLUSIONS +12561 CONCLUSIONS +12562 BACKGROUND +12563 BACKGROUND +12564 METHODS +12565 METHODS +12566 METHODS +12567 METHODS +12568 BACKGROUND +12569 RESULTS +12570 RESULTS +12571 RESULTS +12572 RESULTS +12573 RESULTS +12574 RESULTS +12575 CONCLUSIONS +12576 CONCLUSIONS +12577 BACKGROUND +12578 BACKGROUND +12579 OBJECTIVE +12580 METHODS +12581 METHODS +12582 METHODS +12583 METHODS +12584 METHODS +12585 METHODS +12586 METHODS +12587 METHODS +12588 RESULTS +12589 CONCLUSIONS +12590 CONCLUSIONS +12591 BACKGROUND +12592 BACKGROUND +12593 METHODS +12594 METHODS +12595 METHODS +12596 RESULTS +12597 RESULTS +12598 CONCLUSIONS +12599 OBJECTIVE +12600 METHODS +12601 METHODS +12602 METHODS +12603 METHODS +12604 METHODS +12605 METHODS +12606 METHODS +12607 RESULTS +12608 RESULTS +12609 CONCLUSIONS +12610 RESULTS +12611 CONCLUSIONS +12612 OBJECTIVE +12613 METHODS +12614 METHODS +12615 METHODS +12616 METHODS +12617 METHODS +12618 METHODS +12619 RESULTS +12620 RESULTS +12621 RESULTS +12622 RESULTS +12623 RESULTS +12624 CONCLUSIONS +12625 CONCLUSIONS +12626 CONCLUSIONS +12627 OBJECTIVE +12628 METHODS +12629 METHODS +12630 METHODS +12631 RESULTS +12632 RESULTS +12633 CONCLUSIONS +12634 BACKGROUND +12635 BACKGROUND +12636 BACKGROUND +12637 METHODS +12638 METHODS +12639 METHODS +12640 RESULTS +12641 RESULTS +12642 RESULTS +12643 RESULTS +12644 CONCLUSIONS +12645 CONCLUSIONS +12646 BACKGROUND +12647 METHODS +12648 METHODS +12649 METHODS +12650 METHODS +12651 RESULTS +12652 RESULTS +12653 RESULTS +12654 RESULTS +12655 RESULTS +12656 METHODS +12657 BACKGROUND +12658 OBJECTIVE +12659 METHODS +12660 METHODS +12661 RESULTS +12662 RESULTS +12663 RESULTS +12664 RESULTS +12665 RESULTS +12666 RESULTS +12667 CONCLUSIONS +12668 CONCLUSIONS +12669 BACKGROUND +12670 METHODS +12671 METHODS +12672 METHODS +12673 METHODS +12674 METHODS +12675 RESULTS +12676 RESULTS +12677 RESULTS +12678 RESULTS +12679 RESULTS +12680 RESULTS +12681 RESULTS +12682 RESULTS +12683 RESULTS +12684 CONCLUSIONS +12685 CONCLUSIONS +12686 BACKGROUND +12687 OBJECTIVE +12688 METHODS +12689 METHODS +12690 METHODS +12691 RESULTS +12692 RESULTS +12693 RESULTS +12694 CONCLUSIONS +12695 OBJECTIVE +12696 METHODS +12697 METHODS +12698 METHODS +12699 METHODS +12700 RESULTS +12701 RESULTS +12702 RESULTS +12703 RESULTS +12704 RESULTS +12705 RESULTS +12706 BACKGROUND +12707 METHODS +12708 RESULTS +12709 METHODS +12710 METHODS +12711 RESULTS +12712 RESULTS +12713 METHODS +12714 RESULTS +12715 RESULTS +12716 RESULTS +12717 RESULTS +12718 RESULTS +12719 RESULTS +12720 RESULTS +12721 RESULTS +12722 RESULTS +12723 RESULTS +12724 RESULTS +12725 RESULTS +12726 RESULTS +12727 CONCLUSIONS +12728 BACKGROUND +12729 BACKGROUND +12730 METHODS +12731 METHODS +12732 METHODS +12733 METHODS +12734 METHODS +12735 RESULTS +12736 RESULTS +12737 RESULTS +12738 RESULTS +12739 RESULTS +12740 RESULTS +12741 BACKGROUND +12742 RESULTS +12743 OBJECTIVE +12744 METHODS +12745 METHODS +12746 METHODS +12747 RESULTS +12748 RESULTS +12749 RESULTS +12750 CONCLUSIONS +12751 BACKGROUND +12752 BACKGROUND +12753 OBJECTIVE +12754 METHODS +12755 RESULTS +12756 METHODS +12757 METHODS +12758 METHODS +12759 METHODS +12760 RESULTS +12761 RESULTS +12762 RESULTS +12763 RESULTS +12764 RESULTS +12765 RESULTS +12766 RESULTS +12767 RESULTS +12768 CONCLUSIONS +12769 CONCLUSIONS +12770 CONCLUSIONS +12771 BACKGROUND +12772 METHODS +12773 METHODS +12774 METHODS +12775 RESULTS +12776 RESULTS +12777 RESULTS +12778 RESULTS +12779 RESULTS +12780 RESULTS +12781 CONCLUSIONS +12782 BACKGROUND +12783 BACKGROUND +12784 METHODS +12785 METHODS +12786 RESULTS +12787 RESULTS +12788 RESULTS +12789 RESULTS +12790 RESULTS +12791 CONCLUSIONS +12792 OBJECTIVE +12793 METHODS +12794 METHODS +12795 METHODS +12796 RESULTS +12797 RESULTS +12798 RESULTS +12799 RESULTS +12800 RESULTS +12801 CONCLUSIONS +12802 CONCLUSIONS +12803 CONCLUSIONS +12804 OBJECTIVE +12805 METHODS +12806 METHODS +12807 METHODS +12808 METHODS +12809 METHODS +12810 METHODS +12811 METHODS +12812 METHODS +12813 METHODS +12814 RESULTS +12815 RESULTS +12816 RESULTS +12817 CONCLUSIONS +12818 CONCLUSIONS +12819 BACKGROUND +12820 BACKGROUND +12821 BACKGROUND +12822 METHODS +12823 METHODS +12824 METHODS +12825 METHODS +12826 METHODS +12827 RESULTS +12828 RESULTS +12829 RESULTS +12830 RESULTS +12831 RESULTS +12832 CONCLUSIONS +12833 CONCLUSIONS +12834 CONCLUSIONS +12835 BACKGROUND +12836 CONCLUSIONS +12837 BACKGROUND +12838 OBJECTIVE +12839 METHODS +12840 METHODS +12841 METHODS +12842 METHODS +12843 METHODS +12844 RESULTS +12845 RESULTS +12846 RESULTS +12847 RESULTS +12848 CONCLUSIONS +12849 OBJECTIVE +12850 METHODS +12851 METHODS +12852 RESULTS +12853 RESULTS +12854 RESULTS +12855 RESULTS +12856 RESULTS +12857 RESULTS +12858 RESULTS +12859 CONCLUSIONS +12860 CONCLUSIONS +12861 BACKGROUND +12862 OBJECTIVE +12863 METHODS +12864 METHODS +12865 RESULTS +12866 RESULTS +12867 RESULTS +12868 RESULTS +12869 RESULTS +12870 RESULTS +12871 RESULTS +12872 OBJECTIVE +12873 METHODS +12874 METHODS +12875 METHODS +12876 METHODS +12877 METHODS +12878 METHODS +12879 RESULTS +12880 RESULTS +12881 RESULTS +12882 CONCLUSIONS +12883 BACKGROUND +12884 BACKGROUND +12885 CONCLUSIONS +12886 BACKGROUND +12887 BACKGROUND +12888 BACKGROUND +12889 OBJECTIVE +12890 METHODS +12891 METHODS +12892 METHODS +12893 METHODS +12894 METHODS +12895 RESULTS +12896 RESULTS +12897 RESULTS +12898 CONCLUSIONS +12899 CONCLUSIONS +12900 BACKGROUND +12901 OBJECTIVE +12902 METHODS +12903 METHODS +12904 METHODS +12905 METHODS +12906 METHODS +12907 METHODS +12908 RESULTS +12909 RESULTS +12910 CONCLUSIONS +12911 CONCLUSIONS +12912 BACKGROUND +12913 BACKGROUND +12914 METHODS +12915 METHODS +12916 RESULTS +12917 RESULTS +12918 RESULTS +12919 RESULTS +12920 RESULTS +12921 RESULTS +12922 CONCLUSIONS +12923 METHODS +12924 METHODS +12925 RESULTS +12926 RESULTS +12927 RESULTS +12928 RESULTS +12929 BACKGROUND +12930 BACKGROUND +12931 METHODS +12932 METHODS +12933 METHODS +12934 METHODS +12935 RESULTS +12936 RESULTS +12937 RESULTS +12938 RESULTS +12939 RESULTS +12940 CONCLUSIONS +12941 BACKGROUND +12942 BACKGROUND +12943 BACKGROUND +12944 CONCLUSIONS +12945 METHODS +12946 METHODS +12947 METHODS +12948 METHODS +12949 METHODS +12950 METHODS +12951 METHODS +12952 METHODS +12953 METHODS +12954 METHODS +12955 METHODS +12956 METHODS +12957 METHODS +12958 METHODS +12959 METHODS +12960 BACKGROUND +12961 CONCLUSIONS +12962 CONCLUSIONS +12963 BACKGROUND +12964 BACKGROUND +12965 OBJECTIVE +12966 OBJECTIVE +12967 METHODS +12968 METHODS +12969 RESULTS +12970 RESULTS +12971 RESULTS +12972 CONCLUSIONS +12973 CONCLUSIONS +12974 OBJECTIVE +12975 BACKGROUND +12976 METHODS +12977 METHODS +12978 METHODS +12979 METHODS +12980 METHODS +12981 RESULTS +12982 RESULTS +12983 RESULTS +12984 RESULTS +12985 CONCLUSIONS +12986 OBJECTIVE +12987 METHODS +12988 METHODS +12989 METHODS +12990 METHODS +12991 METHODS +12992 METHODS +12993 METHODS +12994 METHODS +12995 RESULTS +12996 RESULTS +12997 CONCLUSIONS +12998 OBJECTIVE +12999 METHODS +13000 METHODS +13001 RESULTS +13002 RESULTS +13003 CONCLUSIONS +13004 METHODS +13005 BACKGROUND +13006 BACKGROUND +13007 METHODS +13008 METHODS +13009 METHODS +13010 METHODS +13011 METHODS +13012 METHODS +13013 METHODS +13014 RESULTS +13015 RESULTS +13016 RESULTS +13017 RESULTS +13018 RESULTS +13019 CONCLUSIONS +13020 BACKGROUND +13021 BACKGROUND +13022 BACKGROUND +13023 BACKGROUND +13024 METHODS +13025 METHODS +13026 METHODS +13027 METHODS +13028 METHODS +13029 METHODS +13030 METHODS +13031 METHODS +13032 METHODS +13033 METHODS +13034 METHODS +13035 CONCLUSIONS +13036 CONCLUSIONS +13037 CONCLUSIONS +13038 BACKGROUND +13039 BACKGROUND +13040 OBJECTIVE +13041 METHODS +13042 METHODS +13043 METHODS +13044 METHODS +13045 RESULTS +13046 RESULTS +13047 RESULTS +13048 RESULTS +13049 RESULTS +13050 CONCLUSIONS +13051 BACKGROUND +13052 OBJECTIVE +13053 METHODS +13054 METHODS +13055 METHODS +13056 RESULTS +13057 RESULTS +13058 RESULTS +13059 CONCLUSIONS +13060 RESULTS +13061 RESULTS +13062 RESULTS +13063 RESULTS +13064 RESULTS +13065 OBJECTIVE +13066 METHODS +13067 METHODS +13068 METHODS +13069 METHODS +13070 RESULTS +13071 RESULTS +13072 RESULTS +13073 CONCLUSIONS +13074 METHODS +13075 OBJECTIVE +13076 OBJECTIVE +13077 METHODS +13078 METHODS +13079 METHODS +13080 METHODS +13081 METHODS +13082 RESULTS +13083 CONCLUSIONS +13084 CONCLUSIONS +13085 BACKGROUND +13086 BACKGROUND +13087 RESULTS +13088 RESULTS +13089 METHODS +13090 RESULTS +13091 RESULTS +13092 RESULTS +13093 RESULTS +13094 CONCLUSIONS +13095 RESULTS +13096 CONCLUSIONS +13097 BACKGROUND +13098 BACKGROUND +13099 METHODS +13100 BACKGROUND +13101 OBJECTIVE +13102 METHODS +13103 METHODS +13104 METHODS +13105 RESULTS +13106 RESULTS +13107 RESULTS +13108 CONCLUSIONS +13109 CONCLUSIONS +13110 CONCLUSIONS +13111 CONCLUSIONS +13112 OBJECTIVE +13113 METHODS +13114 METHODS +13115 RESULTS +13116 RESULTS +13117 CONCLUSIONS +13118 BACKGROUND +13119 OBJECTIVE +13120 METHODS +13121 METHODS +13122 RESULTS +13123 RESULTS +13124 RESULTS +13125 RESULTS +13126 RESULTS +13127 CONCLUSIONS +13128 OBJECTIVE +13129 OBJECTIVE +13130 METHODS +13131 METHODS +13132 METHODS +13133 METHODS +13134 RESULTS +13135 RESULTS +13136 RESULTS +13137 CONCLUSIONS +13138 OBJECTIVE +13139 METHODS +13140 METHODS +13141 METHODS +13142 METHODS +13143 METHODS +13144 METHODS +13145 RESULTS +13146 RESULTS +13147 RESULTS +13148 CONCLUSIONS +13149 OBJECTIVE +13150 METHODS +13151 METHODS +13152 RESULTS +13153 RESULTS +13154 RESULTS +13155 RESULTS +13156 RESULTS +13157 CONCLUSIONS +13158 CONCLUSIONS +13159 CONCLUSIONS +13160 CONCLUSIONS +13161 OBJECTIVE +13162 METHODS +13163 METHODS +13164 RESULTS +13165 RESULTS +13166 RESULTS +13167 RESULTS +13168 CONCLUSIONS +13169 OBJECTIVE +13170 OBJECTIVE +13171 METHODS +13172 METHODS +13173 RESULTS +13174 RESULTS +13175 RESULTS +13176 RESULTS +13177 CONCLUSIONS +13178 OBJECTIVE +13179 RESULTS +13180 METHODS +13181 METHODS +13182 RESULTS +13183 RESULTS +13184 RESULTS +13185 RESULTS +13186 RESULTS +13187 CONCLUSIONS +13188 BACKGROUND +13189 BACKGROUND +13190 METHODS +13191 RESULTS +13192 METHODS +13193 RESULTS +13194 RESULTS +13195 RESULTS +13196 RESULTS +13197 CONCLUSIONS +13198 CONCLUSIONS +13199 BACKGROUND +13200 OBJECTIVE +13201 RESULTS +13202 OBJECTIVE +13203 METHODS +13204 METHODS +13205 RESULTS +13206 RESULTS +13207 BACKGROUND +13208 CONCLUSIONS +13209 BACKGROUND +13210 METHODS +13211 METHODS +13212 METHODS +13213 METHODS +13214 RESULTS +13215 RESULTS +13216 RESULTS +13217 CONCLUSIONS +13218 CONCLUSIONS +13219 METHODS +13220 METHODS +13221 METHODS +13222 RESULTS +13223 RESULTS +13224 RESULTS +13225 OBJECTIVE +13226 BACKGROUND +13227 OBJECTIVE +13228 METHODS +13229 METHODS +13230 METHODS +13231 METHODS +13232 RESULTS +13233 RESULTS +13234 RESULTS +13235 RESULTS +13236 CONCLUSIONS +13237 CONCLUSIONS +13238 CONCLUSIONS +13239 CONCLUSIONS +13240 OBJECTIVE +13241 METHODS +13242 METHODS +13243 METHODS +13244 METHODS +13245 RESULTS +13246 RESULTS +13247 RESULTS +13248 CONCLUSIONS +13249 OBJECTIVE +13250 METHODS +13251 METHODS +13252 METHODS +13253 METHODS +13254 METHODS +13255 RESULTS +13256 RESULTS +13257 RESULTS +13258 RESULTS +13259 CONCLUSIONS +13260 BACKGROUND +13261 BACKGROUND +13262 METHODS +13263 METHODS +13264 METHODS +13265 METHODS +13266 RESULTS +13267 RESULTS +13268 CONCLUSIONS +13269 OBJECTIVE +13270 METHODS +13271 METHODS +13272 METHODS +13273 METHODS +13274 METHODS +13275 RESULTS +13276 RESULTS +13277 RESULTS +13278 RESULTS +13279 CONCLUSIONS +13280 BACKGROUND +13281 BACKGROUND +13282 BACKGROUND +13283 OBJECTIVE +13284 METHODS +13285 METHODS +13286 METHODS +13287 METHODS +13288 RESULTS +13289 RESULTS +13290 CONCLUSIONS +13291 CONCLUSIONS +13292 BACKGROUND +13293 METHODS +13294 METHODS +13295 RESULTS +13296 RESULTS +13297 RESULTS +13298 RESULTS +13299 RESULTS +13300 RESULTS +13301 RESULTS +13302 RESULTS +13303 OBJECTIVE +13304 METHODS +13305 METHODS +13306 METHODS +13307 METHODS +13308 METHODS +13309 RESULTS +13310 RESULTS +13311 RESULTS +13312 RESULTS +13313 RESULTS +13314 CONCLUSIONS +13315 RESULTS +13316 OBJECTIVE +13317 METHODS +13318 METHODS +13319 METHODS +13320 METHODS +13321 METHODS +13322 RESULTS +13323 RESULTS +13324 RESULTS +13325 RESULTS +13326 CONCLUSIONS +13327 BACKGROUND +13328 BACKGROUND +13329 METHODS +13330 METHODS +13331 METHODS +13332 RESULTS +13333 RESULTS +13334 RESULTS +13335 RESULTS +13336 RESULTS +13337 RESULTS +13338 CONCLUSIONS +13339 CONCLUSIONS +13340 BACKGROUND +13341 CONCLUSIONS +13342 OBJECTIVE +13343 METHODS +13344 METHODS +13345 METHODS +13346 RESULTS +13347 METHODS +13348 METHODS +13349 RESULTS +13350 CONCLUSIONS +13351 BACKGROUND +13352 BACKGROUND +13353 BACKGROUND +13354 BACKGROUND +13355 OBJECTIVE +13356 METHODS +13357 METHODS +13358 METHODS +13359 METHODS +13360 METHODS +13361 RESULTS +13362 CONCLUSIONS +13363 CONCLUSIONS +13364 BACKGROUND +13365 BACKGROUND +13366 BACKGROUND +13367 BACKGROUND +13368 METHODS +13369 METHODS +13370 METHODS +13371 METHODS +13372 METHODS +13373 CONCLUSIONS +13374 BACKGROUND +13375 OBJECTIVE +13376 OBJECTIVE +13377 METHODS +13378 METHODS +13379 METHODS +13380 RESULTS +13381 RESULTS +13382 RESULTS +13383 CONCLUSIONS +13384 CONCLUSIONS +13385 OBJECTIVE +13386 METHODS +13387 METHODS +13388 RESULTS +13389 RESULTS +13390 RESULTS +13391 CONCLUSIONS +13392 OBJECTIVE +13393 METHODS +13394 METHODS +13395 METHODS +13396 METHODS +13397 RESULTS +13398 RESULTS +13399 RESULTS +13400 RESULTS +13401 CONCLUSIONS +13402 OBJECTIVE +13403 BACKGROUND +13404 BACKGROUND +13405 BACKGROUND +13406 OBJECTIVE +13407 METHODS +13408 METHODS +13409 METHODS +13410 METHODS +13411 CONCLUSIONS +13412 CONCLUSIONS +13413 CONCLUSIONS +13414 OBJECTIVE +13415 METHODS +13416 METHODS +13417 METHODS +13418 METHODS +13419 METHODS +13420 RESULTS +13421 METHODS +13422 RESULTS +13423 RESULTS +13424 RESULTS +13425 CONCLUSIONS +13426 OBJECTIVE +13427 METHODS +13428 METHODS +13429 METHODS +13430 METHODS +13431 RESULTS +13432 RESULTS +13433 RESULTS +13434 RESULTS +13435 CONCLUSIONS +13436 CONCLUSIONS +13437 BACKGROUND +13438 BACKGROUND +13439 OBJECTIVE +13440 BACKGROUND +13441 METHODS +13442 METHODS +13443 METHODS +13444 RESULTS +13445 RESULTS +13446 CONCLUSIONS +13447 BACKGROUND +13448 BACKGROUND +13449 METHODS +13450 METHODS +13451 METHODS +13452 RESULTS +13453 RESULTS +13454 CONCLUSIONS +13455 RESULTS +13456 CONCLUSIONS +13457 BACKGROUND +13458 BACKGROUND +13459 OBJECTIVE +13460 METHODS +13461 METHODS +13462 METHODS +13463 METHODS +13464 RESULTS +13465 RESULTS +13466 CONCLUSIONS +13467 CONCLUSIONS +13468 OBJECTIVE +13469 METHODS +13470 METHODS +13471 METHODS +13472 METHODS +13473 RESULTS +13474 METHODS +13475 METHODS +13476 METHODS +13477 RESULTS +13478 RESULTS +13479 CONCLUSIONS +13480 BACKGROUND +13481 BACKGROUND +13482 METHODS +13483 METHODS +13484 METHODS +13485 OBJECTIVE +13486 RESULTS +13487 RESULTS +13488 RESULTS +13489 RESULTS +13490 CONCLUSIONS +13491 BACKGROUND +13492 OBJECTIVE +13493 METHODS +13494 RESULTS +13495 RESULTS +13496 RESULTS +13497 RESULTS +13498 RESULTS +13499 RESULTS +13500 METHODS +13501 RESULTS +13502 RESULTS +13503 CONCLUSIONS +13504 BACKGROUND +13505 BACKGROUND +13506 METHODS +13507 METHODS +13508 METHODS +13509 RESULTS +13510 RESULTS +13511 RESULTS +13512 RESULTS +13513 CONCLUSIONS +13514 CONCLUSIONS +13515 OBJECTIVE +13516 METHODS +13517 OBJECTIVE +13518 METHODS +13519 METHODS +13520 METHODS +13521 METHODS +13522 METHODS +13523 METHODS +13524 RESULTS +13525 RESULTS +13526 RESULTS +13527 CONCLUSIONS +13528 OBJECTIVE +13529 OBJECTIVE +13530 METHODS +13531 METHODS +13532 METHODS +13533 METHODS +13534 RESULTS +13535 RESULTS +13536 CONCLUSIONS +13537 CONCLUSIONS +13538 RESULTS +13539 RESULTS +13540 CONCLUSIONS +13541 BACKGROUND +13542 OBJECTIVE +13543 METHODS +13544 METHODS +13545 METHODS +13546 RESULTS +13547 RESULTS +13548 RESULTS +13549 RESULTS +13550 RESULTS +13551 RESULTS +13552 RESULTS +13553 CONCLUSIONS +13554 CONCLUSIONS +13555 CONCLUSIONS +13556 CONCLUSIONS +13557 OBJECTIVE +13558 METHODS +13559 METHODS +13560 METHODS +13561 METHODS +13562 METHODS +13563 METHODS +13564 METHODS +13565 METHODS +13566 METHODS +13567 RESULTS +13568 RESULTS +13569 RESULTS +13570 RESULTS +13571 CONCLUSIONS +13572 BACKGROUND +13573 OBJECTIVE +13574 RESULTS +13575 METHODS +13576 RESULTS +13577 RESULTS +13578 RESULTS +13579 RESULTS +13580 RESULTS +13581 RESULTS +13582 CONCLUSIONS +13583 BACKGROUND +13584 OBJECTIVE +13585 METHODS +13586 METHODS +13587 METHODS +13588 METHODS +13589 METHODS +13590 METHODS +13591 METHODS +13592 METHODS +13593 RESULTS +13594 RESULTS +13595 RESULTS +13596 RESULTS +13597 CONCLUSIONS +13598 BACKGROUND +13599 BACKGROUND +13600 OBJECTIVE +13601 METHODS +13602 METHODS +13603 RESULTS +13604 RESULTS +13605 RESULTS +13606 CONCLUSIONS +13607 OBJECTIVE +13608 METHODS +13609 METHODS +13610 METHODS +13611 METHODS +13612 METHODS +13613 RESULTS +13614 RESULTS +13615 RESULTS +13616 RESULTS +13617 RESULTS +13618 CONCLUSIONS +13619 BACKGROUND +13620 OBJECTIVE +13621 METHODS +13622 METHODS +13623 RESULTS +13624 CONCLUSIONS +13625 BACKGROUND +13626 BACKGROUND +13627 OBJECTIVE +13628 METHODS +13629 METHODS +13630 RESULTS +13631 RESULTS +13632 CONCLUSIONS +13633 OBJECTIVE +13634 METHODS +13635 METHODS +13636 METHODS +13637 METHODS +13638 METHODS +13639 METHODS +13640 RESULTS +13641 RESULTS +13642 RESULTS +13643 RESULTS +13644 RESULTS +13645 RESULTS +13646 RESULTS +13647 RESULTS +13648 RESULTS +13649 RESULTS +13650 CONCLUSIONS +13651 BACKGROUND +13652 OBJECTIVE +13653 METHODS +13654 METHODS +13655 METHODS +13656 METHODS +13657 RESULTS +13658 RESULTS +13659 RESULTS +13660 RESULTS +13661 RESULTS +13662 RESULTS +13663 CONCLUSIONS +13664 CONCLUSIONS +13665 OBJECTIVE +13666 OBJECTIVE +13667 METHODS +13668 METHODS +13669 METHODS +13670 METHODS +13671 METHODS +13672 METHODS +13673 METHODS +13674 RESULTS +13675 RESULTS +13676 RESULTS +13677 RESULTS +13678 RESULTS +13679 RESULTS +13680 BACKGROUND +13681 OBJECTIVE +13682 CONCLUSIONS +13683 OBJECTIVE +13684 METHODS +13685 METHODS +13686 METHODS +13687 RESULTS +13688 RESULTS +13689 METHODS +13690 RESULTS +13691 RESULTS +13692 CONCLUSIONS +13693 OBJECTIVE +13694 METHODS +13695 RESULTS +13696 RESULTS +13697 RESULTS +13698 RESULTS +13699 CONCLUSIONS +13700 BACKGROUND +13701 OBJECTIVE +13702 METHODS +13703 METHODS +13704 RESULTS +13705 RESULTS +13706 RESULTS +13707 RESULTS +13708 CONCLUSIONS +13709 CONCLUSIONS +13710 OBJECTIVE +13711 METHODS +13712 METHODS +13713 METHODS +13714 METHODS +13715 RESULTS +13716 RESULTS +13717 RESULTS +13718 RESULTS +13719 RESULTS +13720 CONCLUSIONS +13721 OBJECTIVE +13722 METHODS +13723 RESULTS +13724 METHODS +13725 RESULTS +13726 RESULTS +13727 RESULTS +13728 RESULTS +13729 BACKGROUND +13730 BACKGROUND +13731 BACKGROUND +13732 BACKGROUND +13733 METHODS +13734 METHODS +13735 METHODS +13736 RESULTS +13737 CONCLUSIONS +13738 CONCLUSIONS +13739 OBJECTIVE +13740 METHODS +13741 METHODS +13742 METHODS +13743 METHODS +13744 METHODS +13745 METHODS +13746 RESULTS +13747 RESULTS +13748 RESULTS +13749 CONCLUSIONS +13750 CONCLUSIONS +13751 RESULTS +13752 CONCLUSIONS +13753 BACKGROUND +13754 BACKGROUND +13755 OBJECTIVE +13756 METHODS +13757 METHODS +13758 METHODS +13759 RESULTS +13760 RESULTS +13761 RESULTS +13762 RESULTS +13763 CONCLUSIONS +13764 CONCLUSIONS +13765 OBJECTIVE +13766 RESULTS +13767 RESULTS +13768 RESULTS +13769 RESULTS +13770 RESULTS +13771 RESULTS +13772 RESULTS +13773 RESULTS +13774 RESULTS +13775 BACKGROUND +13776 OBJECTIVE +13777 METHODS +13778 METHODS +13779 METHODS +13780 RESULTS +13781 RESULTS +13782 RESULTS +13783 RESULTS +13784 RESULTS +13785 RESULTS +13786 CONCLUSIONS +13787 BACKGROUND +13788 BACKGROUND +13789 METHODS +13790 METHODS +13791 METHODS +13792 RESULTS +13793 RESULTS +13794 RESULTS +13795 RESULTS +13796 RESULTS +13797 RESULTS +13798 RESULTS +13799 CONCLUSIONS +13800 OBJECTIVE +13801 METHODS +13802 METHODS +13803 METHODS +13804 METHODS +13805 METHODS +13806 RESULTS +13807 CONCLUSIONS +13808 CONCLUSIONS +13809 OBJECTIVE +13810 METHODS +13811 METHODS +13812 METHODS +13813 METHODS +13814 METHODS +13815 METHODS +13816 METHODS +13817 METHODS +13818 METHODS +13819 RESULTS +13820 RESULTS +13821 CONCLUSIONS +13822 BACKGROUND +13823 CONCLUSIONS +13824 OBJECTIVE +13825 METHODS +13826 METHODS +13827 METHODS +13828 CONCLUSIONS +13829 RESULTS +13830 CONCLUSIONS +13831 OBJECTIVE +13832 METHODS +13833 METHODS +13834 METHODS +13835 METHODS +13836 METHODS +13837 METHODS +13838 RESULTS +13839 RESULTS +13840 RESULTS +13841 RESULTS +13842 CONCLUSIONS +13843 METHODS +13844 METHODS +13845 RESULTS +13846 RESULTS +13847 RESULTS +13848 RESULTS +13849 RESULTS +13850 CONCLUSIONS +13851 OBJECTIVE +13852 METHODS +13853 METHODS +13854 METHODS +13855 RESULTS +13856 RESULTS +13857 RESULTS +13858 CONCLUSIONS +13859 CONCLUSIONS +13860 OBJECTIVE +13861 METHODS +13862 METHODS +13863 METHODS +13864 RESULTS +13865 RESULTS +13866 CONCLUSIONS +13867 BACKGROUND +13868 METHODS +13869 METHODS +13870 METHODS +13871 RESULTS +13872 RESULTS +13873 CONCLUSIONS +13874 BACKGROUND +13875 BACKGROUND +13876 BACKGROUND +13877 METHODS +13878 METHODS +13879 RESULTS +13880 CONCLUSIONS +13881 BACKGROUND +13882 OBJECTIVE +13883 METHODS +13884 METHODS +13885 METHODS +13886 METHODS +13887 RESULTS +13888 RESULTS +13889 RESULTS +13890 RESULTS +13891 CONCLUSIONS +13892 CONCLUSIONS +13893 BACKGROUND +13894 BACKGROUND +13895 BACKGROUND +13896 METHODS +13897 METHODS +13898 METHODS +13899 RESULTS +13900 RESULTS +13901 RESULTS +13902 RESULTS +13903 RESULTS +13904 CONCLUSIONS +13905 CONCLUSIONS +13906 BACKGROUND +13907 BACKGROUND +13908 BACKGROUND +13909 METHODS +13910 METHODS +13911 METHODS +13912 METHODS +13913 RESULTS +13914 RESULTS +13915 RESULTS +13916 RESULTS +13917 RESULTS +13918 CONCLUSIONS +13919 OBJECTIVE +13920 METHODS +13921 METHODS +13922 METHODS +13923 METHODS +13924 RESULTS +13925 RESULTS +13926 RESULTS +13927 RESULTS +13928 RESULTS +13929 RESULTS +13930 RESULTS +13931 RESULTS +13932 RESULTS +13933 RESULTS +13934 CONCLUSIONS +13935 RESULTS +13936 BACKGROUND +13937 OBJECTIVE +13938 METHODS +13939 METHODS +13940 METHODS +13941 METHODS +13942 METHODS +13943 RESULTS +13944 RESULTS +13945 RESULTS +13946 CONCLUSIONS +13947 BACKGROUND +13948 OBJECTIVE +13949 METHODS +13950 OBJECTIVE +13951 METHODS +13952 METHODS +13953 METHODS +13954 RESULTS +13955 RESULTS +13956 CONCLUSIONS +13957 BACKGROUND +13958 BACKGROUND +13959 OBJECTIVE +13960 METHODS +13961 METHODS +13962 METHODS +13963 RESULTS +13964 RESULTS +13965 RESULTS +13966 RESULTS +13967 CONCLUSIONS +13968 RESULTS +13969 CONCLUSIONS +13970 OBJECTIVE +13971 METHODS +13972 METHODS +13973 METHODS +13974 RESULTS +13975 RESULTS +13976 RESULTS +13977 CONCLUSIONS +13978 RESULTS +13979 CONCLUSIONS +13980 CONCLUSIONS +13981 BACKGROUND +13982 OBJECTIVE +13983 METHODS +13984 METHODS +13985 RESULTS +13986 RESULTS +13987 CONCLUSIONS +13988 BACKGROUND +13989 BACKGROUND +13990 BACKGROUND +13991 BACKGROUND +13992 BACKGROUND +13993 CONCLUSIONS +13994 METHODS +13995 CONCLUSIONS +13996 METHODS +13997 METHODS +13998 METHODS +13999 METHODS +14000 METHODS +14001 BACKGROUND +14002 BACKGROUND +14003 BACKGROUND +14004 OBJECTIVE +14005 METHODS +14006 METHODS +14007 METHODS +14008 METHODS +14009 METHODS +14010 METHODS +14011 METHODS +14012 RESULTS +14013 RESULTS +14014 RESULTS +14015 RESULTS +14016 RESULTS +14017 CONCLUSIONS +14018 RESULTS +14019 RESULTS +14020 CONCLUSIONS +14021 OBJECTIVE +14022 METHODS +14023 METHODS +14024 METHODS +14025 METHODS +14026 METHODS +14027 METHODS +14028 RESULTS +14029 RESULTS +14030 RESULTS +14031 CONCLUSIONS +14032 BACKGROUND +14033 METHODS +14034 RESULTS +14035 METHODS +14036 RESULTS +14037 RESULTS +14038 RESULTS +14039 CONCLUSIONS +14040 BACKGROUND +14041 OBJECTIVE +14042 METHODS +14043 METHODS +14044 RESULTS +14045 RESULTS +14046 RESULTS +14047 CONCLUSIONS +14048 OBJECTIVE +14049 METHODS +14050 METHODS +14051 METHODS +14052 METHODS +14053 RESULTS +14054 RESULTS +14055 CONCLUSIONS +14056 CONCLUSIONS +14057 CONCLUSIONS +14058 CONCLUSIONS +14059 OBJECTIVE +14060 METHODS +14061 METHODS +14062 METHODS +14063 METHODS +14064 RESULTS +14065 RESULTS +14066 RESULTS +14067 CONCLUSIONS +14068 CONCLUSIONS +14069 BACKGROUND +14070 OBJECTIVE +14071 METHODS +14072 METHODS +14073 METHODS +14074 RESULTS +14075 RESULTS +14076 RESULTS +14077 RESULTS +14078 RESULTS +14079 RESULTS +14080 CONCLUSIONS +14081 OBJECTIVE +14082 METHODS +14083 METHODS +14084 METHODS +14085 RESULTS +14086 RESULTS +14087 RESULTS +14088 CONCLUSIONS +14089 BACKGROUND +14090 METHODS +14091 METHODS +14092 RESULTS +14093 RESULTS +14094 CONCLUSIONS +14095 OBJECTIVE +14096 OBJECTIVE +14097 METHODS +14098 METHODS +14099 METHODS +14100 METHODS +14101 METHODS +14102 METHODS +14103 RESULTS +14104 METHODS +14105 METHODS +14106 RESULTS +14107 RESULTS +14108 RESULTS +14109 RESULTS +14110 CONCLUSIONS +14111 BACKGROUND +14112 OBJECTIVE +14113 METHODS +14114 METHODS +14115 METHODS +14116 RESULTS +14117 RESULTS +14118 METHODS +14119 RESULTS +14120 RESULTS +14121 RESULTS +14122 OBJECTIVE +14123 METHODS +14124 METHODS +14125 METHODS +14126 METHODS +14127 METHODS +14128 RESULTS +14129 CONCLUSIONS +14130 OBJECTIVE +14131 METHODS +14132 METHODS +14133 RESULTS +14134 RESULTS +14135 RESULTS +14136 RESULTS +14137 RESULTS +14138 RESULTS +14139 RESULTS +14140 CONCLUSIONS +14141 BACKGROUND +14142 CONCLUSIONS +14143 METHODS +14144 METHODS +14145 RESULTS +14146 RESULTS +14147 RESULTS +14148 RESULTS +14149 RESULTS +14150 RESULTS +14151 RESULTS +14152 RESULTS +14153 CONCLUSIONS +14154 CONCLUSIONS +14155 CONCLUSIONS +14156 BACKGROUND +14157 OBJECTIVE +14158 METHODS +14159 METHODS +14160 METHODS +14161 METHODS +14162 METHODS +14163 RESULTS +14164 RESULTS +14165 RESULTS +14166 CONCLUSIONS +14167 BACKGROUND +14168 BACKGROUND +14169 METHODS +14170 METHODS +14171 METHODS +14172 RESULTS +14173 RESULTS +14174 RESULTS +14175 CONCLUSIONS +14176 CONCLUSIONS +14177 CONCLUSIONS +14178 BACKGROUND +14179 OBJECTIVE +14180 METHODS +14181 METHODS +14182 METHODS +14183 RESULTS +14184 RESULTS +14185 RESULTS +14186 CONCLUSIONS +14187 OBJECTIVE +14188 METHODS +14189 METHODS +14190 METHODS +14191 METHODS +14192 METHODS +14193 RESULTS +14194 RESULTS +14195 RESULTS +14196 RESULTS +14197 RESULTS +14198 CONCLUSIONS +14199 BACKGROUND +14200 BACKGROUND +14201 BACKGROUND +14202 BACKGROUND +14203 BACKGROUND +14204 METHODS +14205 METHODS +14206 METHODS +14207 METHODS +14208 METHODS +14209 CONCLUSIONS +14210 CONCLUSIONS +14211 BACKGROUND +14212 BACKGROUND +14213 BACKGROUND +14214 METHODS +14215 METHODS +14216 METHODS +14217 METHODS +14218 RESULTS +14219 RESULTS +14220 RESULTS +14221 CONCLUSIONS +14222 RESULTS +14223 BACKGROUND +14224 BACKGROUND +14225 OBJECTIVE +14226 METHODS +14227 METHODS +14228 METHODS +14229 METHODS +14230 METHODS +14231 RESULTS +14232 RESULTS +14233 RESULTS +14234 RESULTS +14235 CONCLUSIONS +14236 BACKGROUND +14237 BACKGROUND +14238 BACKGROUND +14239 BACKGROUND +14240 METHODS +14241 METHODS +14242 METHODS +14243 METHODS +14244 BACKGROUND +14245 BACKGROUND +14246 BACKGROUND +14247 BACKGROUND +14248 BACKGROUND +14249 BACKGROUND +14250 BACKGROUND +14251 BACKGROUND +14252 BACKGROUND +14253 METHODS +14254 METHODS +14255 RESULTS +14256 RESULTS +14257 RESULTS +14258 RESULTS +14259 CONCLUSIONS +14260 BACKGROUND +14261 BACKGROUND +14262 METHODS +14263 METHODS +14264 METHODS +14265 METHODS +14266 RESULTS +14267 CONCLUSIONS +14268 RESULTS +14269 RESULTS +14270 CONCLUSIONS +14271 BACKGROUND +14272 OBJECTIVE +14273 METHODS +14274 METHODS +14275 METHODS +14276 RESULTS +14277 RESULTS +14278 RESULTS +14279 RESULTS +14280 RESULTS +14281 RESULTS +14282 CONCLUSIONS +14283 CONCLUSIONS +14284 BACKGROUND +14285 METHODS +14286 RESULTS +14287 RESULTS +14288 CONCLUSIONS +14289 OBJECTIVE +14290 BACKGROUND +14291 BACKGROUND +14292 OBJECTIVE +14293 METHODS +14294 METHODS +14295 METHODS +14296 METHODS +14297 METHODS +14298 METHODS +14299 RESULTS +14300 RESULTS +14301 RESULTS +14302 RESULTS +14303 RESULTS +14304 RESULTS +14305 BACKGROUND +14306 CONCLUSIONS +14307 CONCLUSIONS +14308 BACKGROUND +14309 OBJECTIVE +14310 METHODS +14311 METHODS +14312 METHODS +14313 METHODS +14314 METHODS +14315 METHODS +14316 RESULTS +14317 RESULTS +14318 RESULTS +14319 CONCLUSIONS +14320 OBJECTIVE +14321 METHODS +14322 METHODS +14323 METHODS +14324 METHODS +14325 RESULTS +14326 RESULTS +14327 RESULTS +14328 RESULTS +14329 RESULTS +14330 RESULTS +14331 RESULTS +14332 CONCLUSIONS +14333 OBJECTIVE +14334 BACKGROUND +14335 BACKGROUND +14336 METHODS +14337 METHODS +14338 METHODS +14339 METHODS +14340 METHODS +14341 METHODS +14342 METHODS +14343 METHODS +14344 RESULTS +14345 RESULTS +14346 RESULTS +14347 RESULTS +14348 RESULTS +14349 CONCLUSIONS +14350 RESULTS +14351 CONCLUSIONS +14352 CONCLUSIONS +14353 OBJECTIVE +14354 OBJECTIVE +14355 METHODS +14356 METHODS +14357 METHODS +14358 RESULTS +14359 RESULTS +14360 CONCLUSIONS +14361 CONCLUSIONS +14362 BACKGROUND +14363 OBJECTIVE +14364 METHODS +14365 METHODS +14366 METHODS +14367 METHODS +14368 RESULTS +14369 RESULTS +14370 RESULTS +14371 CONCLUSIONS +14372 RESULTS +14373 CONCLUSIONS +14374 CONCLUSIONS +14375 OBJECTIVE +14376 METHODS +14377 METHODS +14378 METHODS +14379 METHODS +14380 METHODS +14381 RESULTS +14382 RESULTS +14383 RESULTS +14384 RESULTS +14385 RESULTS +14386 CONCLUSIONS +14387 CONCLUSIONS +14388 OBJECTIVE +14389 METHODS +14390 METHODS +14391 METHODS +14392 METHODS +14393 RESULTS +14394 RESULTS +14395 RESULTS +14396 CONCLUSIONS +14397 OBJECTIVE +14398 METHODS +14399 METHODS +14400 METHODS +14401 METHODS +14402 RESULTS +14403 RESULTS +14404 RESULTS +14405 CONCLUSIONS +14406 CONCLUSIONS +14407 OBJECTIVE +14408 METHODS +14409 METHODS +14410 METHODS +14411 METHODS +14412 METHODS +14413 METHODS +14414 RESULTS +14415 RESULTS +14416 CONCLUSIONS +14417 CONCLUSIONS +14418 BACKGROUND +14419 BACKGROUND +14420 CONCLUSIONS +14421 BACKGROUND +14422 BACKGROUND +14423 METHODS +14424 METHODS +14425 METHODS +14426 RESULTS +14427 RESULTS +14428 RESULTS +14429 RESULTS +14430 CONCLUSIONS +14431 RESULTS +14432 BACKGROUND +14433 BACKGROUND +14434 OBJECTIVE +14435 OBJECTIVE +14436 METHODS +14437 RESULTS +14438 RESULTS +14439 RESULTS +14440 RESULTS +14441 CONCLUSIONS +14442 OBJECTIVE +14443 METHODS +14444 METHODS +14445 METHODS +14446 METHODS +14447 METHODS +14448 RESULTS +14449 RESULTS +14450 RESULTS +14451 CONCLUSIONS +14452 CONCLUSIONS +14453 BACKGROUND +14454 BACKGROUND +14455 METHODS +14456 METHODS +14457 RESULTS +14458 RESULTS +14459 CONCLUSIONS +14460 BACKGROUND +14461 BACKGROUND +14462 OBJECTIVE +14463 METHODS +14464 METHODS +14465 METHODS +14466 METHODS +14467 METHODS +14468 METHODS +14469 METHODS +14470 RESULTS +14471 RESULTS +14472 RESULTS +14473 RESULTS +14474 CONCLUSIONS +14475 OBJECTIVE +14476 METHODS +14477 METHODS +14478 METHODS +14479 RESULTS +14480 RESULTS +14481 RESULTS +14482 CONCLUSIONS +14483 OBJECTIVE +14484 METHODS +14485 OBJECTIVE +14486 METHODS +14487 RESULTS +14488 RESULTS +14489 RESULTS +14490 CONCLUSIONS +14491 BACKGROUND +14492 OBJECTIVE +14493 METHODS +14494 METHODS +14495 RESULTS +14496 RESULTS +14497 RESULTS +14498 RESULTS +14499 RESULTS +14500 RESULTS +14501 CONCLUSIONS +14502 BACKGROUND +14503 OBJECTIVE +14504 METHODS +14505 METHODS +14506 METHODS +14507 METHODS +14508 RESULTS +14509 RESULTS +14510 RESULTS +14511 RESULTS +14512 RESULTS +14513 RESULTS +14514 CONCLUSIONS +14515 CONCLUSIONS +14516 BACKGROUND +14517 BACKGROUND +14518 BACKGROUND +14519 METHODS +14520 METHODS +14521 RESULTS +14522 METHODS +14523 METHODS +14524 OBJECTIVE +14525 METHODS +14526 METHODS +14527 RESULTS +14528 RESULTS +14529 CONCLUSIONS +14530 RESULTS +14531 BACKGROUND +14532 OBJECTIVE +14533 METHODS +14534 METHODS +14535 METHODS +14536 METHODS +14537 METHODS +14538 METHODS +14539 METHODS +14540 METHODS +14541 METHODS +14542 METHODS +14543 METHODS +14544 RESULTS +14545 BACKGROUND +14546 CONCLUSIONS +14547 BACKGROUND +14548 BACKGROUND +14549 OBJECTIVE +14550 METHODS +14551 METHODS +14552 METHODS +14553 METHODS +14554 METHODS +14555 METHODS +14556 RESULTS +14557 RESULTS +14558 RESULTS +14559 CONCLUSIONS +14560 BACKGROUND +14561 BACKGROUND +14562 OBJECTIVE +14563 METHODS +14564 RESULTS +14565 METHODS +14566 RESULTS +14567 RESULTS +14568 CONCLUSIONS +14569 BACKGROUND +14570 BACKGROUND +14571 OBJECTIVE +14572 METHODS +14573 METHODS +14574 METHODS +14575 METHODS +14576 METHODS +14577 RESULTS +14578 RESULTS +14579 RESULTS +14580 RESULTS +14581 RESULTS +14582 CONCLUSIONS +14583 OBJECTIVE +14584 METHODS +14585 METHODS +14586 RESULTS +14587 METHODS +14588 RESULTS +14589 RESULTS +14590 RESULTS +14591 RESULTS +14592 CONCLUSIONS +14593 BACKGROUND +14594 OBJECTIVE +14595 METHODS +14596 RESULTS +14597 METHODS +14598 METHODS +14599 METHODS +14600 RESULTS +14601 RESULTS +14602 RESULTS +14603 RESULTS +14604 RESULTS +14605 CONCLUSIONS +14606 BACKGROUND +14607 BACKGROUND +14608 BACKGROUND +14609 BACKGROUND +14610 BACKGROUND +14611 OBJECTIVE +14612 METHODS +14613 METHODS +14614 METHODS +14615 METHODS +14616 METHODS +14617 RESULTS +14618 RESULTS +14619 RESULTS +14620 RESULTS +14621 RESULTS +14622 CONCLUSIONS +14623 OBJECTIVE +14624 METHODS +14625 METHODS +14626 METHODS +14627 METHODS +14628 METHODS +14629 METHODS +14630 RESULTS +14631 RESULTS +14632 RESULTS +14633 RESULTS +14634 RESULTS +14635 RESULTS +14636 RESULTS +14637 CONCLUSIONS +14638 METHODS +14639 METHODS +14640 RESULTS +14641 RESULTS +14642 RESULTS +14643 RESULTS +14644 RESULTS +14645 OBJECTIVE +14646 METHODS +14647 BACKGROUND +14648 METHODS +14649 METHODS +14650 METHODS +14651 METHODS +14652 METHODS +14653 RESULTS +14654 RESULTS +14655 RESULTS +14656 RESULTS +14657 RESULTS +14658 BACKGROUND +14659 CONCLUSIONS +14660 OBJECTIVE +14661 METHODS +14662 METHODS +14663 METHODS +14664 RESULTS +14665 RESULTS +14666 RESULTS +14667 RESULTS +14668 RESULTS +14669 RESULTS +14670 RESULTS +14671 CONCLUSIONS +14672 CONCLUSIONS +14673 BACKGROUND +14674 OBJECTIVE +14675 METHODS +14676 METHODS +14677 RESULTS +14678 RESULTS +14679 RESULTS +14680 RESULTS +14681 RESULTS +14682 CONCLUSIONS +14683 BACKGROUND +14684 BACKGROUND +14685 OBJECTIVE +14686 METHODS +14687 RESULTS +14688 RESULTS +14689 RESULTS +14690 RESULTS +14691 RESULTS +14692 CONCLUSIONS +14693 CONCLUSIONS +14694 CONCLUSIONS +14695 CONCLUSIONS +14696 OBJECTIVE +14697 METHODS +14698 METHODS +14699 METHODS +14700 METHODS +14701 METHODS +14702 RESULTS +14703 RESULTS +14704 CONCLUSIONS +14705 BACKGROUND +14706 OBJECTIVE +14707 METHODS +14708 METHODS +14709 METHODS +14710 RESULTS +14711 RESULTS +14712 RESULTS +14713 RESULTS +14714 RESULTS +14715 CONCLUSIONS +14716 RESULTS +14717 BACKGROUND +14718 RESULTS +14719 METHODS +14720 METHODS +14721 RESULTS +14722 RESULTS +14723 RESULTS +14724 RESULTS +14725 CONCLUSIONS +14726 BACKGROUND +14727 BACKGROUND +14728 METHODS +14729 METHODS +14730 RESULTS +14731 RESULTS +14732 RESULTS +14733 RESULTS +14734 RESULTS +14735 CONCLUSIONS +14736 CONCLUSIONS +14737 BACKGROUND +14738 BACKGROUND +14739 BACKGROUND +14740 BACKGROUND +14741 METHODS +14742 METHODS +14743 RESULTS +14744 RESULTS +14745 RESULTS +14746 CONCLUSIONS +14747 CONCLUSIONS +14748 BACKGROUND +14749 OBJECTIVE +14750 METHODS +14751 METHODS +14752 METHODS +14753 METHODS +14754 RESULTS +14755 RESULTS +14756 RESULTS +14757 RESULTS +14758 CONCLUSIONS +14759 OBJECTIVE +14760 METHODS +14761 METHODS +14762 METHODS +14763 METHODS +14764 METHODS +14765 METHODS +14766 RESULTS +14767 RESULTS +14768 RESULTS +14769 RESULTS +14770 RESULTS +14771 CONCLUSIONS +14772 BACKGROUND +14773 OBJECTIVE +14774 METHODS +14775 METHODS +14776 METHODS +14777 RESULTS +14778 RESULTS +14779 RESULTS +14780 RESULTS +14781 CONCLUSIONS +14782 RESULTS +14783 METHODS +14784 OBJECTIVE +14785 METHODS +14786 METHODS +14787 METHODS +14788 METHODS +14789 RESULTS +14790 RESULTS +14791 RESULTS +14792 CONCLUSIONS +14793 BACKGROUND +14794 OBJECTIVE +14795 METHODS +14796 METHODS +14797 METHODS +14798 METHODS +14799 METHODS +14800 RESULTS +14801 RESULTS +14802 CONCLUSIONS +14803 OBJECTIVE +14804 OBJECTIVE +14805 METHODS +14806 METHODS +14807 METHODS +14808 METHODS +14809 RESULTS +14810 RESULTS +14811 RESULTS +14812 RESULTS +14813 CONCLUSIONS +14814 CONCLUSIONS +14815 OBJECTIVE +14816 METHODS +14817 METHODS +14818 METHODS +14819 METHODS +14820 RESULTS +14821 CONCLUSIONS +14822 RESULTS +14823 RESULTS +14824 CONCLUSIONS +14825 CONCLUSIONS +14826 CONCLUSIONS +14827 BACKGROUND +14828 BACKGROUND +14829 OBJECTIVE +14830 METHODS +14831 METHODS +14832 METHODS +14833 METHODS +14834 RESULTS +14835 RESULTS +14836 RESULTS +14837 CONCLUSIONS +14838 CONCLUSIONS +14839 OBJECTIVE +14840 OBJECTIVE +14841 METHODS +14842 METHODS +14843 METHODS +14844 RESULTS +14845 RESULTS +14846 RESULTS +14847 CONCLUSIONS +14848 CONCLUSIONS +14849 BACKGROUND +14850 OBJECTIVE +14851 METHODS +14852 METHODS +14853 METHODS +14854 METHODS +14855 METHODS +14856 METHODS +14857 METHODS +14858 RESULTS +14859 RESULTS +14860 CONCLUSIONS +14861 OBJECTIVE +14862 RESULTS +14863 METHODS +14864 METHODS +14865 RESULTS +14866 RESULTS +14867 RESULTS +14868 CONCLUSIONS +14869 OBJECTIVE +14870 METHODS +14871 METHODS +14872 METHODS +14873 METHODS +14874 METHODS +14875 METHODS +14876 METHODS +14877 METHODS +14878 METHODS +14879 METHODS +14880 METHODS +14881 METHODS +14882 RESULTS +14883 RESULTS +14884 RESULTS +14885 RESULTS +14886 RESULTS +14887 RESULTS +14888 RESULTS +14889 RESULTS +14890 RESULTS +14891 RESULTS +14892 RESULTS +14893 BACKGROUND +14894 BACKGROUND +14895 METHODS +14896 METHODS +14897 METHODS +14898 METHODS +14899 RESULTS +14900 RESULTS +14901 CONCLUSIONS +14902 CONCLUSIONS +14903 BACKGROUND +14904 OBJECTIVE +14905 METHODS +14906 METHODS +14907 METHODS +14908 METHODS +14909 RESULTS +14910 RESULTS +14911 RESULTS +14912 CONCLUSIONS +14913 BACKGROUND +14914 BACKGROUND +14915 BACKGROUND +14916 METHODS +14917 METHODS +14918 METHODS +14919 RESULTS +14920 CONCLUSIONS +14921 CONCLUSIONS +14922 BACKGROUND +14923 OBJECTIVE +14924 METHODS +14925 METHODS +14926 RESULTS +14927 RESULTS +14928 RESULTS +14929 RESULTS +14930 RESULTS +14931 CONCLUSIONS +14932 OBJECTIVE +14933 METHODS +14934 METHODS +14935 RESULTS +14936 RESULTS +14937 RESULTS +14938 CONCLUSIONS +14939 OBJECTIVE +14940 METHODS +14941 METHODS +14942 METHODS +14943 RESULTS +14944 RESULTS +14945 CONCLUSIONS +14946 OBJECTIVE +14947 METHODS +14948 METHODS +14949 METHODS +14950 METHODS +14951 RESULTS +14952 RESULTS +14953 RESULTS +14954 RESULTS +14955 RESULTS +14956 BACKGROUND +14957 CONCLUSIONS +14958 CONCLUSIONS +14959 METHODS +14960 METHODS +14961 METHODS +14962 METHODS +14963 METHODS +14964 METHODS +14965 METHODS +14966 RESULTS +14967 RESULTS +14968 RESULTS +14969 RESULTS +14970 RESULTS +14971 CONCLUSIONS +14972 OBJECTIVE +14973 METHODS +14974 METHODS +14975 METHODS +14976 METHODS +14977 RESULTS +14978 RESULTS +14979 RESULTS +14980 RESULTS +14981 CONCLUSIONS +14982 OBJECTIVE +14983 METHODS +14984 METHODS +14985 METHODS +14986 METHODS +14987 METHODS +14988 METHODS +14989 RESULTS +14990 RESULTS +14991 RESULTS +14992 RESULTS +14993 CONCLUSIONS +14994 CONCLUSIONS +14995 CONCLUSIONS +14996 OBJECTIVE +14997 METHODS +14998 RESULTS +14999 METHODS +15000 METHODS +15001 RESULTS +15002 RESULTS +15003 RESULTS +15004 CONCLUSIONS +15005 CONCLUSIONS +15006 OBJECTIVE +15007 METHODS +15008 METHODS +15009 METHODS +15010 METHODS +15011 METHODS +15012 METHODS +15013 METHODS +15014 RESULTS +15015 RESULTS +15016 RESULTS +15017 RESULTS +15018 BACKGROUND +15019 RESULTS +15020 BACKGROUND +15021 OBJECTIVE +15022 METHODS +15023 METHODS +15024 METHODS +15025 METHODS +15026 RESULTS +15027 RESULTS +15028 RESULTS +15029 CONCLUSIONS +15030 CONCLUSIONS +15031 BACKGROUND +15032 BACKGROUND +15033 BACKGROUND +15034 METHODS +15035 METHODS +15036 CONCLUSIONS +15037 METHODS +15038 RESULTS +15039 RESULTS +15040 RESULTS +15041 RESULTS +15042 CONCLUSIONS +15043 CONCLUSIONS +15044 CONCLUSIONS +15045 OBJECTIVE +15046 METHODS +15047 METHODS +15048 METHODS +15049 METHODS +15050 METHODS +15051 RESULTS +15052 RESULTS +15053 RESULTS +15054 RESULTS +15055 CONCLUSIONS +15056 BACKGROUND +15057 OBJECTIVE +15058 METHODS +15059 METHODS +15060 METHODS +15061 METHODS +15062 RESULTS +15063 CONCLUSIONS +15064 CONCLUSIONS +15065 BACKGROUND +15066 METHODS +15067 METHODS +15068 RESULTS +15069 RESULTS +15070 RESULTS +15071 RESULTS +15072 RESULTS +15073 CONCLUSIONS +15074 OBJECTIVE +15075 METHODS +15076 METHODS +15077 METHODS +15078 METHODS +15079 RESULTS +15080 RESULTS +15081 CONCLUSIONS +15082 BACKGROUND +15083 BACKGROUND +15084 OBJECTIVE +15085 METHODS +15086 METHODS +15087 RESULTS +15088 RESULTS +15089 RESULTS +15090 RESULTS +15091 RESULTS +15092 RESULTS +15093 RESULTS +15094 RESULTS +15095 RESULTS +15096 CONCLUSIONS +15097 CONCLUSIONS +15098 BACKGROUND +15099 OBJECTIVE +15100 METHODS +15101 METHODS +15102 RESULTS +15103 RESULTS +15104 RESULTS +15105 RESULTS +15106 RESULTS +15107 RESULTS +15108 CONCLUSIONS +15109 CONCLUSIONS +15110 OBJECTIVE +15111 METHODS +15112 METHODS +15113 METHODS +15114 METHODS +15115 METHODS +15116 RESULTS +15117 RESULTS +15118 RESULTS +15119 RESULTS +15120 RESULTS +15121 CONCLUSIONS +15122 BACKGROUND +15123 OBJECTIVE +15124 METHODS +15125 METHODS +15126 METHODS +15127 METHODS +15128 METHODS +15129 RESULTS +15130 RESULTS +15131 RESULTS +15132 RESULTS +15133 CONCLUSIONS +15134 CONCLUSIONS +15135 OBJECTIVE +15136 METHODS +15137 METHODS +15138 METHODS +15139 METHODS +15140 RESULTS +15141 RESULTS +15142 RESULTS +15143 RESULTS +15144 CONCLUSIONS +15145 CONCLUSIONS +15146 BACKGROUND +15147 BACKGROUND +15148 BACKGROUND +15149 BACKGROUND +15150 BACKGROUND +15151 OBJECTIVE +15152 METHODS +15153 METHODS +15154 RESULTS +15155 RESULTS +15156 RESULTS +15157 RESULTS +15158 RESULTS +15159 RESULTS +15160 CONCLUSIONS +15161 OBJECTIVE +15162 METHODS +15163 RESULTS +15164 RESULTS +15165 CONCLUSIONS +15166 CONCLUSIONS +15167 OBJECTIVE +15168 METHODS +15169 METHODS +15170 METHODS +15171 RESULTS +15172 RESULTS +15173 RESULTS +15174 RESULTS +15175 CONCLUSIONS +15176 CONCLUSIONS +15177 BACKGROUND +15178 OBJECTIVE +15179 METHODS +15180 METHODS +15181 RESULTS +15182 RESULTS +15183 RESULTS +15184 RESULTS +15185 RESULTS +15186 RESULTS +15187 CONCLUSIONS +15188 BACKGROUND +15189 METHODS +15190 METHODS +15191 METHODS +15192 METHODS +15193 METHODS +15194 RESULTS +15195 RESULTS +15196 RESULTS +15197 CONCLUSIONS +15198 CONCLUSIONS +15199 BACKGROUND +15200 BACKGROUND +15201 BACKGROUND +15202 METHODS +15203 METHODS +15204 METHODS +15205 RESULTS +15206 RESULTS +15207 RESULTS +15208 CONCLUSIONS +15209 CONCLUSIONS +15210 OBJECTIVE +15211 METHODS +15212 METHODS +15213 METHODS +15214 METHODS +15215 METHODS +15216 METHODS +15217 RESULTS +15218 RESULTS +15219 CONCLUSIONS +15220 BACKGROUND +15221 OBJECTIVE +15222 METHODS +15223 METHODS +15224 METHODS +15225 METHODS +15226 METHODS +15227 RESULTS +15228 CONCLUSIONS +15229 CONCLUSIONS +15230 CONCLUSIONS +15231 CONCLUSIONS +15232 BACKGROUND +15233 BACKGROUND +15234 BACKGROUND +15235 METHODS +15236 METHODS +15237 METHODS +15238 METHODS +15239 RESULTS +15240 RESULTS +15241 RESULTS +15242 RESULTS +15243 RESULTS +15244 RESULTS +15245 CONCLUSIONS +15246 RESULTS +15247 CONCLUSIONS +15248 BACKGROUND +15249 BACKGROUND +15250 OBJECTIVE +15251 METHODS +15252 METHODS +15253 METHODS +15254 METHODS +15255 METHODS +15256 RESULTS +15257 RESULTS +15258 RESULTS +15259 CONCLUSIONS +15260 CONCLUSIONS +15261 BACKGROUND +15262 METHODS +15263 METHODS +15264 METHODS +15265 METHODS +15266 METHODS +15267 RESULTS +15268 RESULTS +15269 METHODS +15270 CONCLUSIONS +15271 RESULTS +15272 OBJECTIVE +15273 METHODS +15274 METHODS +15275 METHODS +15276 METHODS +15277 METHODS +15278 RESULTS +15279 RESULTS +15280 RESULTS +15281 RESULTS +15282 RESULTS +15283 RESULTS +15284 CONCLUSIONS +15285 CONCLUSIONS +15286 CONCLUSIONS +15287 BACKGROUND +15288 OBJECTIVE +15289 METHODS +15290 METHODS +15291 METHODS +15292 METHODS +15293 METHODS +15294 METHODS +15295 RESULTS +15296 RESULTS +15297 RESULTS +15298 CONCLUSIONS +15299 BACKGROUND +15300 BACKGROUND +15301 BACKGROUND +15302 BACKGROUND +15303 METHODS +15304 METHODS +15305 RESULTS +15306 RESULTS +15307 RESULTS +15308 RESULTS +15309 RESULTS +15310 CONCLUSIONS +15311 CONCLUSIONS +15312 OBJECTIVE +15313 BACKGROUND +15314 BACKGROUND +15315 BACKGROUND +15316 METHODS +15317 METHODS +15318 METHODS +15319 METHODS +15320 RESULTS +15321 RESULTS +15322 RESULTS +15323 RESULTS +15324 RESULTS +15325 RESULTS +15326 RESULTS +15327 RESULTS +15328 RESULTS +15329 RESULTS +15330 RESULTS +15331 RESULTS +15332 CONCLUSIONS +15333 CONCLUSIONS +15334 BACKGROUND +15335 METHODS +15336 METHODS +15337 RESULTS +15338 RESULTS +15339 CONCLUSIONS +15340 OBJECTIVE +15341 METHODS +15342 METHODS +15343 METHODS +15344 METHODS +15345 METHODS +15346 METHODS +15347 RESULTS +15348 RESULTS +15349 RESULTS +15350 RESULTS +15351 CONCLUSIONS +15352 CONCLUSIONS +15353 OBJECTIVE +15354 METHODS +15355 METHODS +15356 METHODS +15357 METHODS +15358 METHODS +15359 RESULTS +15360 RESULTS +15361 RESULTS +15362 RESULTS +15363 RESULTS +15364 RESULTS +15365 RESULTS +15366 RESULTS +15367 CONCLUSIONS +15368 RESULTS +15369 OBJECTIVE +15370 METHODS +15371 METHODS +15372 METHODS +15373 METHODS +15374 METHODS +15375 METHODS +15376 METHODS +15377 RESULTS +15378 RESULTS +15379 RESULTS +15380 CONCLUSIONS +15381 OBJECTIVE +15382 METHODS +15383 METHODS +15384 RESULTS +15385 RESULTS +15386 RESULTS +15387 RESULTS +15388 RESULTS +15389 RESULTS +15390 RESULTS +15391 CONCLUSIONS +15392 CONCLUSIONS +15393 RESULTS +15394 OBJECTIVE +15395 METHODS +15396 METHODS +15397 METHODS +15398 METHODS +15399 RESULTS +15400 RESULTS +15401 RESULTS +15402 RESULTS +15403 CONCLUSIONS +15404 CONCLUSIONS +15405 BACKGROUND +15406 OBJECTIVE +15407 METHODS +15408 METHODS +15409 METHODS +15410 METHODS +15411 RESULTS +15412 RESULTS +15413 RESULTS +15414 RESULTS +15415 CONCLUSIONS +15416 BACKGROUND +15417 BACKGROUND +15418 METHODS +15419 METHODS +15420 METHODS +15421 METHODS +15422 METHODS +15423 METHODS +15424 RESULTS +15425 RESULTS +15426 RESULTS +15427 RESULTS +15428 RESULTS +15429 RESULTS +15430 RESULTS +15431 OBJECTIVE +15432 METHODS +15433 METHODS +15434 METHODS +15435 METHODS +15436 METHODS +15437 METHODS +15438 METHODS +15439 METHODS +15440 RESULTS +15441 RESULTS +15442 RESULTS +15443 RESULTS +15444 CONCLUSIONS +15445 OBJECTIVE +15446 METHODS +15447 METHODS +15448 METHODS +15449 RESULTS +15450 RESULTS +15451 CONCLUSIONS +15452 CONCLUSIONS +15453 OBJECTIVE +15454 METHODS +15455 METHODS +15456 RESULTS +15457 RESULTS +15458 RESULTS +15459 RESULTS +15460 RESULTS +15461 RESULTS +15462 CONCLUSIONS +15463 OBJECTIVE +15464 METHODS +15465 METHODS +15466 RESULTS +15467 RESULTS +15468 RESULTS +15469 RESULTS +15470 RESULTS +15471 CONCLUSIONS +15472 CONCLUSIONS +15473 RESULTS +15474 RESULTS +15475 OBJECTIVE +15476 OBJECTIVE +15477 METHODS +15478 METHODS +15479 RESULTS +15480 RESULTS +15481 RESULTS +15482 RESULTS +15483 RESULTS +15484 CONCLUSIONS +15485 RESULTS +15486 METHODS +15487 OBJECTIVE +15488 METHODS +15489 METHODS +15490 METHODS +15491 METHODS +15492 METHODS +15493 RESULTS +15494 RESULTS +15495 RESULTS +15496 CONCLUSIONS +15497 CONCLUSIONS +15498 BACKGROUND +15499 BACKGROUND +15500 OBJECTIVE +15501 METHODS +15502 METHODS +15503 METHODS +15504 RESULTS +15505 RESULTS +15506 RESULTS +15507 RESULTS +15508 RESULTS +15509 RESULTS +15510 RESULTS +15511 CONCLUSIONS +15512 CONCLUSIONS +15513 CONCLUSIONS +15514 OBJECTIVE +15515 METHODS +15516 METHODS +15517 METHODS +15518 METHODS +15519 METHODS +15520 METHODS +15521 METHODS +15522 RESULTS +15523 RESULTS +15524 CONCLUSIONS +15525 CONCLUSIONS +15526 OBJECTIVE +15527 METHODS +15528 METHODS +15529 METHODS +15530 METHODS +15531 METHODS +15532 METHODS +15533 RESULTS +15534 RESULTS +15535 RESULTS +15536 RESULTS +15537 RESULTS +15538 CONCLUSIONS +15539 OBJECTIVE +15540 METHODS +15541 METHODS +15542 METHODS +15543 METHODS +15544 METHODS +15545 RESULTS +15546 CONCLUSIONS +15547 BACKGROUND +15548 METHODS +15549 METHODS +15550 METHODS +15551 METHODS +15552 RESULTS +15553 RESULTS +15554 RESULTS +15555 RESULTS +15556 RESULTS +15557 RESULTS +15558 RESULTS +15559 RESULTS +15560 RESULTS +15561 RESULTS +15562 CONCLUSIONS +15563 CONCLUSIONS +15564 CONCLUSIONS +15565 CONCLUSIONS +15566 BACKGROUND +15567 OBJECTIVE +15568 METHODS +15569 METHODS +15570 METHODS +15571 RESULTS +15572 RESULTS +15573 RESULTS +15574 RESULTS +15575 RESULTS +15576 CONCLUSIONS +15577 BACKGROUND +15578 METHODS +15579 METHODS +15580 METHODS +15581 METHODS +15582 RESULTS +15583 RESULTS +15584 RESULTS +15585 RESULTS +15586 CONCLUSIONS +15587 CONCLUSIONS +15588 OBJECTIVE +15589 METHODS +15590 METHODS +15591 RESULTS +15592 RESULTS +15593 RESULTS +15594 CONCLUSIONS +15595 BACKGROUND +15596 BACKGROUND +15597 CONCLUSIONS +15598 BACKGROUND +15599 BACKGROUND +15600 METHODS +15601 BACKGROUND +15602 METHODS +15603 METHODS +15604 CONCLUSIONS +15605 BACKGROUND +15606 BACKGROUND +15607 OBJECTIVE +15608 BACKGROUND +15609 OBJECTIVE +15610 METHODS +15611 METHODS +15612 METHODS +15613 RESULTS +15614 RESULTS +15615 RESULTS +15616 CONCLUSIONS +15617 CONCLUSIONS +15618 CONCLUSIONS +15619 OBJECTIVE +15620 OBJECTIVE +15621 METHODS +15622 METHODS +15623 METHODS +15624 METHODS +15625 METHODS +15626 RESULTS +15627 RESULTS +15628 RESULTS +15629 RESULTS +15630 RESULTS +15631 RESULTS +15632 CONCLUSIONS +15633 CONCLUSIONS +15634 OBJECTIVE +15635 METHODS +15636 METHODS +15637 METHODS +15638 RESULTS +15639 RESULTS +15640 CONCLUSIONS +15641 BACKGROUND +15642 BACKGROUND +15643 OBJECTIVE +15644 METHODS +15645 METHODS +15646 METHODS +15647 RESULTS +15648 RESULTS +15649 RESULTS +15650 RESULTS +15651 RESULTS +15652 RESULTS +15653 CONCLUSIONS +15654 CONCLUSIONS +15655 BACKGROUND +15656 BACKGROUND +15657 METHODS +15658 METHODS +15659 METHODS +15660 METHODS +15661 METHODS +15662 METHODS +15663 METHODS +15664 METHODS +15665 RESULTS +15666 RESULTS +15667 RESULTS +15668 RESULTS +15669 RESULTS +15670 CONCLUSIONS +15671 BACKGROUND +15672 BACKGROUND +15673 METHODS +15674 METHODS +15675 OBJECTIVE +15676 METHODS +15677 METHODS +15678 METHODS +15679 RESULTS +15680 RESULTS +15681 RESULTS +15682 RESULTS +15683 RESULTS +15684 CONCLUSIONS +15685 BACKGROUND +15686 BACKGROUND +15687 OBJECTIVE +15688 OBJECTIVE +15689 METHODS +15690 METHODS +15691 METHODS +15692 METHODS +15693 METHODS +15694 METHODS +15695 RESULTS +15696 RESULTS +15697 RESULTS +15698 RESULTS +15699 RESULTS +15700 RESULTS +15701 RESULTS +15702 CONCLUSIONS +15703 OBJECTIVE +15704 METHODS +15705 CONCLUSIONS +15706 METHODS +15707 METHODS +15708 METHODS +15709 RESULTS +15710 CONCLUSIONS +15711 RESULTS +15712 CONCLUSIONS +15713 RESULTS +15714 OBJECTIVE +15715 METHODS +15716 METHODS +15717 METHODS +15718 METHODS +15719 METHODS +15720 RESULTS +15721 RESULTS +15722 RESULTS +15723 RESULTS +15724 RESULTS +15725 CONCLUSIONS +15726 METHODS +15727 METHODS +15728 METHODS +15729 METHODS +15730 RESULTS +15731 RESULTS +15732 RESULTS +15733 CONCLUSIONS +15734 CONCLUSIONS +15735 OBJECTIVE +15736 METHODS +15737 METHODS +15738 METHODS +15739 RESULTS +15740 RESULTS +15741 RESULTS +15742 CONCLUSIONS +15743 CONCLUSIONS +15744 CONCLUSIONS +15745 CONCLUSIONS +15746 BACKGROUND +15747 OBJECTIVE +15748 METHODS +15749 METHODS +15750 METHODS +15751 METHODS +15752 METHODS +15753 RESULTS +15754 RESULTS +15755 RESULTS +15756 RESULTS +15757 RESULTS +15758 RESULTS +15759 CONCLUSIONS +15760 CONCLUSIONS +15761 BACKGROUND +15762 METHODS +15763 METHODS +15764 METHODS +15765 METHODS +15766 METHODS +15767 METHODS +15768 METHODS +15769 METHODS +15770 RESULTS +15771 RESULTS +15772 RESULTS +15773 RESULTS +15774 RESULTS +15775 RESULTS +15776 RESULTS +15777 RESULTS +15778 RESULTS +15779 BACKGROUND +15780 BACKGROUND +15781 BACKGROUND +15782 METHODS +15783 METHODS +15784 METHODS +15785 METHODS +15786 RESULTS +15787 RESULTS +15788 RESULTS +15789 RESULTS +15790 RESULTS +15791 RESULTS +15792 CONCLUSIONS +15793 BACKGROUND +15794 BACKGROUND +15795 BACKGROUND +15796 OBJECTIVE +15797 BACKGROUND +15798 BACKGROUND +15799 BACKGROUND +15800 OBJECTIVE +15801 METHODS +15802 METHODS +15803 METHODS +15804 METHODS +15805 METHODS +15806 METHODS +15807 METHODS +15808 METHODS +15809 RESULTS +15810 RESULTS +15811 RESULTS +15812 RESULTS +15813 RESULTS +15814 CONCLUSIONS +15815 OBJECTIVE +15816 METHODS +15817 METHODS +15818 METHODS +15819 METHODS +15820 RESULTS +15821 RESULTS +15822 RESULTS +15823 CONCLUSIONS +15824 BACKGROUND +15825 BACKGROUND +15826 BACKGROUND +15827 METHODS +15828 METHODS +15829 METHODS +15830 METHODS +15831 METHODS +15832 RESULTS +15833 RESULTS +15834 RESULTS +15835 BACKGROUND +15836 OBJECTIVE +15837 CONCLUSIONS +15838 OBJECTIVE +15839 METHODS +15840 METHODS +15841 METHODS +15842 RESULTS +15843 CONCLUSIONS +15844 CONCLUSIONS +15845 OBJECTIVE +15846 METHODS +15847 METHODS +15848 METHODS +15849 METHODS +15850 METHODS +15851 RESULTS +15852 RESULTS +15853 RESULTS +15854 CONCLUSIONS +15855 CONCLUSIONS +15856 CONCLUSIONS +15857 CONCLUSIONS +15858 CONCLUSIONS +15859 OBJECTIVE +15860 METHODS +15861 METHODS +15862 METHODS +15863 METHODS +15864 RESULTS +15865 RESULTS +15866 RESULTS +15867 RESULTS +15868 RESULTS +15869 CONCLUSIONS +15870 OBJECTIVE +15871 METHODS +15872 METHODS +15873 METHODS +15874 METHODS +15875 METHODS +15876 RESULTS +15877 RESULTS +15878 RESULTS +15879 RESULTS +15880 RESULTS +15881 CONCLUSIONS +15882 CONCLUSIONS +15883 OBJECTIVE +15884 METHODS +15885 METHODS +15886 METHODS +15887 METHODS +15888 METHODS +15889 RESULTS +15890 RESULTS +15891 METHODS +15892 RESULTS +15893 RESULTS +15894 RESULTS +15895 RESULTS +15896 RESULTS +15897 RESULTS +15898 RESULTS +15899 RESULTS +15900 CONCLUSIONS +15901 RESULTS +15902 BACKGROUND +15903 METHODS +15904 METHODS +15905 METHODS +15906 METHODS +15907 METHODS +15908 METHODS +15909 RESULTS +15910 RESULTS +15911 RESULTS +15912 RESULTS +15913 CONCLUSIONS +15914 OBJECTIVE +15915 BACKGROUND +15916 METHODS +15917 METHODS +15918 RESULTS +15919 RESULTS +15920 RESULTS +15921 RESULTS +15922 CONCLUSIONS +15923 CONCLUSIONS +15924 CONCLUSIONS +15925 OBJECTIVE +15926 OBJECTIVE +15927 METHODS +15928 METHODS +15929 METHODS +15930 METHODS +15931 METHODS +15932 RESULTS +15933 RESULTS +15934 RESULTS +15935 RESULTS +15936 RESULTS +15937 RESULTS +15938 CONCLUSIONS +15939 BACKGROUND +15940 BACKGROUND +15941 OBJECTIVE +15942 OBJECTIVE +15943 METHODS +15944 METHODS +15945 METHODS +15946 METHODS +15947 METHODS +15948 RESULTS +15949 RESULTS +15950 CONCLUSIONS +15951 CONCLUSIONS +15952 RESULTS +15953 RESULTS +15954 CONCLUSIONS +15955 CONCLUSIONS +15956 BACKGROUND +15957 OBJECTIVE +15958 METHODS +15959 METHODS +15960 METHODS +15961 METHODS +15962 RESULTS +15963 RESULTS +15964 BACKGROUND +15965 CONCLUSIONS +15966 BACKGROUND +15967 BACKGROUND +15968 METHODS +15969 METHODS +15970 METHODS +15971 METHODS +15972 METHODS +15973 METHODS +15974 METHODS +15975 CONCLUSIONS +15976 CONCLUSIONS +15977 CONCLUSIONS +15978 BACKGROUND +15979 BACKGROUND +15980 OBJECTIVE +15981 METHODS +15982 METHODS +15983 METHODS +15984 METHODS +15985 METHODS +15986 CONCLUSIONS +15987 RESULTS +15988 CONCLUSIONS +15989 OBJECTIVE +15990 BACKGROUND +15991 BACKGROUND +15992 BACKGROUND +15993 METHODS +15994 METHODS +15995 METHODS +15996 METHODS +15997 RESULTS +15998 RESULTS +15999 RESULTS +16000 RESULTS +16001 CONCLUSIONS +16002 OBJECTIVE +16003 METHODS +16004 METHODS +16005 METHODS +16006 METHODS +16007 METHODS +16008 RESULTS +16009 RESULTS +16010 CONCLUSIONS +16011 OBJECTIVE +16012 OBJECTIVE +16013 OBJECTIVE +16014 METHODS +16015 METHODS +16016 RESULTS +16017 RESULTS +16018 RESULTS +16019 RESULTS +16020 RESULTS +16021 CONCLUSIONS +16022 CONCLUSIONS +16023 BACKGROUND +16024 METHODS +16025 METHODS +16026 METHODS +16027 RESULTS +16028 RESULTS +16029 RESULTS +16030 RESULTS +16031 RESULTS +16032 CONCLUSIONS +16033 CONCLUSIONS +16034 OBJECTIVE +16035 METHODS +16036 METHODS +16037 RESULTS +16038 RESULTS +16039 CONCLUSIONS +16040 OBJECTIVE +16041 METHODS +16042 METHODS +16043 METHODS +16044 METHODS +16045 METHODS +16046 RESULTS +16047 RESULTS +16048 RESULTS +16049 RESULTS +16050 CONCLUSIONS +16051 BACKGROUND +16052 CONCLUSIONS +16053 BACKGROUND +16054 OBJECTIVE +16055 METHODS +16056 METHODS +16057 RESULTS +16058 RESULTS +16059 RESULTS +16060 CONCLUSIONS +16061 OBJECTIVE +16062 METHODS +16063 METHODS +16064 RESULTS +16065 METHODS +16066 METHODS +16067 RESULTS +16068 CONCLUSIONS +16069 OBJECTIVE +16070 RESULTS +16071 METHODS +16072 OBJECTIVE +16073 METHODS +16074 RESULTS +16075 METHODS +16076 CONCLUSIONS +16077 CONCLUSIONS +16078 CONCLUSIONS +16079 BACKGROUND +16080 BACKGROUND +16081 CONCLUSIONS +16082 OBJECTIVE +16083 RESULTS +16084 METHODS +16085 METHODS +16086 METHODS +16087 METHODS +16088 METHODS +16089 METHODS +16090 METHODS +16091 METHODS +16092 METHODS +16093 METHODS +16094 METHODS +16095 METHODS +16096 METHODS +16097 RESULTS +16098 RESULTS +16099 RESULTS +16100 RESULTS +16101 RESULTS +16102 RESULTS +16103 RESULTS +16104 RESULTS +16105 RESULTS +16106 BACKGROUND +16107 OBJECTIVE +16108 METHODS +16109 METHODS +16110 METHODS +16111 METHODS +16112 METHODS +16113 RESULTS +16114 RESULTS +16115 RESULTS +16116 RESULTS +16117 CONCLUSIONS +16118 CONCLUSIONS +16119 BACKGROUND +16120 OBJECTIVE +16121 OBJECTIVE +16122 METHODS +16123 METHODS +16124 METHODS +16125 METHODS +16126 METHODS +16127 RESULTS +16128 RESULTS +16129 RESULTS +16130 RESULTS +16131 RESULTS +16132 BACKGROUND +16133 CONCLUSIONS +16134 CONCLUSIONS +16135 OBJECTIVE +16136 BACKGROUND +16137 BACKGROUND +16138 METHODS +16139 METHODS +16140 METHODS +16141 METHODS +16142 RESULTS +16143 RESULTS +16144 RESULTS +16145 CONCLUSIONS +16146 CONCLUSIONS +16147 CONCLUSIONS +16148 OBJECTIVE +16149 METHODS +16150 METHODS +16151 CONCLUSIONS +16152 RESULTS +16153 RESULTS +16154 RESULTS +16155 RESULTS +16156 RESULTS +16157 RESULTS +16158 RESULTS +16159 BACKGROUND +16160 OBJECTIVE +16161 METHODS +16162 METHODS +16163 METHODS +16164 METHODS +16165 METHODS +16166 RESULTS +16167 RESULTS +16168 RESULTS +16169 RESULTS +16170 CONCLUSIONS +16171 OBJECTIVE +16172 METHODS +16173 METHODS +16174 RESULTS +16175 METHODS +16176 METHODS +16177 METHODS +16178 METHODS +16179 RESULTS +16180 RESULTS +16181 RESULTS +16182 RESULTS +16183 RESULTS +16184 RESULTS +16185 CONCLUSIONS +16186 BACKGROUND +16187 BACKGROUND +16188 METHODS +16189 METHODS +16190 METHODS +16191 RESULTS +16192 RESULTS +16193 CONCLUSIONS +16194 BACKGROUND +16195 BACKGROUND +16196 OBJECTIVE +16197 METHODS +16198 RESULTS +16199 RESULTS +16200 RESULTS +16201 CONCLUSIONS +16202 CONCLUSIONS +16203 CONCLUSIONS +16204 CONCLUSIONS +16205 OBJECTIVE +16206 METHODS +16207 METHODS +16208 METHODS +16209 METHODS +16210 METHODS +16211 RESULTS +16212 METHODS +16213 METHODS +16214 METHODS +16215 RESULTS +16216 RESULTS +16217 RESULTS +16218 RESULTS +16219 CONCLUSIONS +16220 BACKGROUND +16221 METHODS +16222 METHODS +16223 METHODS +16224 METHODS +16225 METHODS +16226 RESULTS +16227 RESULTS +16228 RESULTS +16229 RESULTS +16230 CONCLUSIONS +16231 RESULTS +16232 OBJECTIVE +16233 BACKGROUND +16234 OBJECTIVE +16235 METHODS +16236 METHODS +16237 METHODS +16238 METHODS +16239 METHODS +16240 RESULTS +16241 RESULTS +16242 RESULTS +16243 CONCLUSIONS +16244 CONCLUSIONS +16245 BACKGROUND +16246 BACKGROUND +16247 BACKGROUND +16248 BACKGROUND +16249 METHODS +16250 METHODS +16251 METHODS +16252 METHODS +16253 METHODS +16254 BACKGROUND +16255 BACKGROUND +16256 BACKGROUND +16257 BACKGROUND +16258 METHODS +16259 RESULTS +16260 RESULTS +16261 BACKGROUND +16262 METHODS +16263 METHODS +16264 METHODS +16265 METHODS +16266 METHODS +16267 RESULTS +16268 RESULTS +16269 RESULTS +16270 RESULTS +16271 CONCLUSIONS +16272 OBJECTIVE +16273 METHODS +16274 METHODS +16275 METHODS +16276 RESULTS +16277 RESULTS +16278 CONCLUSIONS +16279 CONCLUSIONS +16280 OBJECTIVE +16281 METHODS +16282 METHODS +16283 METHODS +16284 METHODS +16285 RESULTS +16286 RESULTS +16287 RESULTS +16288 RESULTS +16289 RESULTS +16290 RESULTS +16291 RESULTS +16292 RESULTS +16293 BACKGROUND +16294 RESULTS +16295 OBJECTIVE +16296 METHODS +16297 METHODS +16298 METHODS +16299 METHODS +16300 METHODS +16301 RESULTS +16302 RESULTS +16303 RESULTS +16304 RESULTS +16305 RESULTS +16306 CONCLUSIONS +16307 CONCLUSIONS +16308 BACKGROUND +16309 BACKGROUND +16310 OBJECTIVE +16311 METHODS +16312 RESULTS +16313 RESULTS +16314 CONCLUSIONS +16315 CONCLUSIONS +16316 OBJECTIVE +16317 METHODS +16318 METHODS +16319 METHODS +16320 METHODS +16321 RESULTS +16322 CONCLUSIONS +16323 CONCLUSIONS +16324 CONCLUSIONS +16325 BACKGROUND +16326 OBJECTIVE +16327 METHODS +16328 METHODS +16329 METHODS +16330 METHODS +16331 METHODS +16332 METHODS +16333 RESULTS +16334 RESULTS +16335 RESULTS +16336 RESULTS +16337 RESULTS +16338 CONCLUSIONS +16339 CONCLUSIONS +16340 RESULTS +16341 OBJECTIVE +16342 METHODS +16343 METHODS +16344 METHODS +16345 METHODS +16346 RESULTS +16347 RESULTS +16348 RESULTS +16349 RESULTS +16350 RESULTS +16351 RESULTS +16352 CONCLUSIONS +16353 CONCLUSIONS +16354 CONCLUSIONS +16355 CONCLUSIONS +16356 BACKGROUND +16357 CONCLUSIONS +16358 BACKGROUND +16359 METHODS +16360 METHODS +16361 METHODS +16362 RESULTS +16363 RESULTS +16364 RESULTS +16365 RESULTS +16366 RESULTS +16367 CONCLUSIONS +16368 BACKGROUND +16369 OBJECTIVE +16370 RESULTS +16371 CONCLUSIONS +16372 RESULTS +16373 CONCLUSIONS +16374 CONCLUSIONS +16375 BACKGROUND +16376 BACKGROUND +16377 BACKGROUND +16378 OBJECTIVE +16379 METHODS +16380 METHODS +16381 METHODS +16382 METHODS +16383 METHODS +16384 METHODS +16385 RESULTS +16386 RESULTS +16387 CONCLUSIONS +16388 OBJECTIVE +16389 METHODS +16390 METHODS +16391 METHODS +16392 METHODS +16393 METHODS +16394 METHODS +16395 RESULTS +16396 CONCLUSIONS +16397 CONCLUSIONS +16398 BACKGROUND +16399 OBJECTIVE +16400 METHODS +16401 METHODS +16402 METHODS +16403 CONCLUSIONS +16404 RESULTS +16405 CONCLUSIONS +16406 CONCLUSIONS +16407 OBJECTIVE +16408 METHODS +16409 RESULTS +16410 CONCLUSIONS +16411 RESULTS +16412 BACKGROUND +16413 BACKGROUND +16414 OBJECTIVE +16415 METHODS +16416 METHODS +16417 METHODS +16418 METHODS +16419 RESULTS +16420 RESULTS +16421 RESULTS +16422 RESULTS +16423 RESULTS +16424 RESULTS +16425 RESULTS +16426 RESULTS +16427 CONCLUSIONS +16428 RESULTS +16429 OBJECTIVE +16430 METHODS +16431 METHODS +16432 METHODS +16433 METHODS +16434 METHODS +16435 METHODS +16436 RESULTS +16437 RESULTS +16438 RESULTS +16439 RESULTS +16440 RESULTS +16441 CONCLUSIONS +16442 BACKGROUND +16443 OBJECTIVE +16444 METHODS +16445 METHODS +16446 RESULTS +16447 RESULTS +16448 RESULTS +16449 RESULTS +16450 RESULTS +16451 CONCLUSIONS +16452 CONCLUSIONS +16453 BACKGROUND +16454 OBJECTIVE +16455 METHODS +16456 METHODS +16457 METHODS +16458 METHODS +16459 METHODS +16460 METHODS +16461 RESULTS +16462 RESULTS +16463 RESULTS +16464 CONCLUSIONS +16465 OBJECTIVE +16466 METHODS +16467 METHODS +16468 METHODS +16469 RESULTS +16470 RESULTS +16471 RESULTS +16472 RESULTS +16473 RESULTS +16474 CONCLUSIONS +16475 CONCLUSIONS +16476 BACKGROUND +16477 BACKGROUND +16478 METHODS +16479 METHODS +16480 METHODS +16481 RESULTS +16482 RESULTS +16483 RESULTS +16484 RESULTS +16485 RESULTS +16486 CONCLUSIONS +16487 RESULTS +16488 CONCLUSIONS +16489 CONCLUSIONS +16490 OBJECTIVE +16491 METHODS +16492 METHODS +16493 RESULTS +16494 RESULTS +16495 CONCLUSIONS +16496 OBJECTIVE +16497 METHODS +16498 RESULTS +16499 RESULTS +16500 RESULTS +16501 RESULTS +16502 RESULTS +16503 CONCLUSIONS +16504 CONCLUSIONS +16505 OBJECTIVE +16506 METHODS +16507 METHODS +16508 METHODS +16509 METHODS +16510 RESULTS +16511 RESULTS +16512 RESULTS +16513 RESULTS +16514 CONCLUSIONS +16515 CONCLUSIONS +16516 BACKGROUND +16517 BACKGROUND +16518 OBJECTIVE +16519 METHODS +16520 METHODS +16521 METHODS +16522 RESULTS +16523 RESULTS +16524 CONCLUSIONS +16525 BACKGROUND +16526 BACKGROUND +16527 METHODS +16528 METHODS +16529 METHODS +16530 CONCLUSIONS +16531 METHODS +16532 CONCLUSIONS +16533 OBJECTIVE +16534 METHODS +16535 METHODS +16536 METHODS +16537 RESULTS +16538 RESULTS +16539 RESULTS +16540 CONCLUSIONS +16541 OBJECTIVE +16542 METHODS +16543 METHODS +16544 METHODS +16545 METHODS +16546 METHODS +16547 RESULTS +16548 METHODS +16549 RESULTS +16550 RESULTS +16551 RESULTS +16552 RESULTS +16553 CONCLUSIONS +16554 CONCLUSIONS +16555 OBJECTIVE +16556 METHODS +16557 METHODS +16558 METHODS +16559 METHODS +16560 METHODS +16561 METHODS +16562 METHODS +16563 RESULTS +16564 RESULTS +16565 RESULTS +16566 RESULTS +16567 RESULTS +16568 CONCLUSIONS +16569 OBJECTIVE +16570 METHODS +16571 RESULTS +16572 METHODS +16573 METHODS +16574 METHODS +16575 METHODS +16576 METHODS +16577 METHODS +16578 CONCLUSIONS +16579 RESULTS +16580 RESULTS +16581 RESULTS +16582 RESULTS +16583 CONCLUSIONS +16584 CONCLUSIONS +16585 CONCLUSIONS +16586 BACKGROUND +16587 METHODS +16588 METHODS +16589 METHODS +16590 RESULTS +16591 RESULTS +16592 RESULTS +16593 RESULTS +16594 CONCLUSIONS +16595 CONCLUSIONS +16596 BACKGROUND +16597 BACKGROUND +16598 BACKGROUND +16599 METHODS +16600 METHODS +16601 METHODS +16602 RESULTS +16603 RESULTS +16604 RESULTS +16605 RESULTS +16606 RESULTS +16607 RESULTS +16608 CONCLUSIONS +16609 CONCLUSIONS +16610 BACKGROUND +16611 BACKGROUND +16612 BACKGROUND +16613 OBJECTIVE +16614 METHODS +16615 METHODS +16616 METHODS +16617 METHODS +16618 METHODS +16619 METHODS +16620 METHODS +16621 RESULTS +16622 RESULTS +16623 RESULTS +16624 RESULTS +16625 CONCLUSIONS +16626 CONCLUSIONS +16627 BACKGROUND +16628 BACKGROUND +16629 METHODS +16630 METHODS +16631 METHODS +16632 RESULTS +16633 RESULTS +16634 RESULTS +16635 RESULTS +16636 OBJECTIVE +16637 METHODS +16638 METHODS +16639 METHODS +16640 METHODS +16641 METHODS +16642 METHODS +16643 METHODS +16644 RESULTS +16645 RESULTS +16646 RESULTS +16647 RESULTS +16648 RESULTS +16649 RESULTS +16650 CONCLUSIONS +16651 CONCLUSIONS +16652 OBJECTIVE +16653 METHODS +16654 METHODS +16655 METHODS +16656 METHODS +16657 METHODS +16658 METHODS +16659 RESULTS +16660 RESULTS +16661 RESULTS +16662 RESULTS +16663 RESULTS +16664 RESULTS +16665 RESULTS +16666 RESULTS +16667 CONCLUSIONS +16668 CONCLUSIONS +16669 BACKGROUND +16670 OBJECTIVE +16671 METHODS +16672 METHODS +16673 METHODS +16674 METHODS +16675 METHODS +16676 METHODS +16677 METHODS +16678 METHODS +16679 RESULTS +16680 RESULTS +16681 RESULTS +16682 CONCLUSIONS +16683 BACKGROUND +16684 BACKGROUND +16685 OBJECTIVE +16686 METHODS +16687 METHODS +16688 METHODS +16689 METHODS +16690 RESULTS +16691 RESULTS +16692 RESULTS +16693 RESULTS +16694 CONCLUSIONS +16695 CONCLUSIONS +16696 CONCLUSIONS +16697 BACKGROUND +16698 CONCLUSIONS +16699 BACKGROUND +16700 BACKGROUND +16701 METHODS +16702 METHODS +16703 RESULTS +16704 RESULTS +16705 RESULTS +16706 CONCLUSIONS +16707 CONCLUSIONS +16708 OBJECTIVE +16709 METHODS +16710 METHODS +16711 METHODS +16712 METHODS +16713 RESULTS +16714 RESULTS +16715 RESULTS +16716 RESULTS +16717 CONCLUSIONS +16718 CONCLUSIONS +16719 BACKGROUND +16720 OBJECTIVE +16721 METHODS +16722 METHODS +16723 METHODS +16724 RESULTS +16725 METHODS +16726 METHODS +16727 RESULTS +16728 RESULTS +16729 RESULTS +16730 RESULTS +16731 RESULTS +16732 RESULTS +16733 RESULTS +16734 RESULTS +16735 CONCLUSIONS +16736 CONCLUSIONS +16737 RESULTS +16738 BACKGROUND +16739 BACKGROUND +16740 METHODS +16741 METHODS +16742 METHODS +16743 METHODS +16744 METHODS +16745 METHODS +16746 RESULTS +16747 RESULTS +16748 RESULTS +16749 RESULTS +16750 RESULTS +16751 CONCLUSIONS +16752 BACKGROUND +16753 BACKGROUND +16754 METHODS +16755 METHODS +16756 RESULTS +16757 RESULTS +16758 RESULTS +16759 RESULTS +16760 RESULTS +16761 CONCLUSIONS +16762 CONCLUSIONS +16763 BACKGROUND +16764 BACKGROUND +16765 OBJECTIVE +16766 METHODS +16767 METHODS +16768 RESULTS +16769 RESULTS +16770 RESULTS +16771 CONCLUSIONS +16772 CONCLUSIONS +16773 BACKGROUND +16774 METHODS +16775 METHODS +16776 RESULTS +16777 RESULTS +16778 RESULTS +16779 RESULTS +16780 CONCLUSIONS +16781 METHODS +16782 BACKGROUND +16783 BACKGROUND +16784 OBJECTIVE +16785 METHODS +16786 METHODS +16787 METHODS +16788 RESULTS +16789 RESULTS +16790 RESULTS +16791 RESULTS +16792 RESULTS +16793 RESULTS +16794 RESULTS +16795 RESULTS +16796 CONCLUSIONS +16797 CONCLUSIONS +16798 BACKGROUND +16799 BACKGROUND +16800 BACKGROUND +16801 BACKGROUND +16802 OBJECTIVE +16803 BACKGROUND +16804 METHODS +16805 METHODS +16806 METHODS +16807 BACKGROUND +16808 METHODS +16809 METHODS +16810 METHODS +16811 METHODS +16812 METHODS +16813 BACKGROUND +16814 OBJECTIVE +16815 OBJECTIVE +16816 METHODS +16817 METHODS +16818 METHODS +16819 METHODS +16820 RESULTS +16821 RESULTS +16822 CONCLUSIONS +16823 CONCLUSIONS +16824 BACKGROUND +16825 OBJECTIVE +16826 METHODS +16827 METHODS +16828 METHODS +16829 METHODS +16830 METHODS +16831 METHODS +16832 RESULTS +16833 RESULTS +16834 RESULTS +16835 RESULTS +16836 RESULTS +16837 RESULTS +16838 RESULTS +16839 RESULTS +16840 CONCLUSIONS +16841 RESULTS +16842 BACKGROUND +16843 BACKGROUND +16844 METHODS +16845 METHODS +16846 METHODS +16847 RESULTS +16848 RESULTS +16849 CONCLUSIONS +16850 OBJECTIVE +16851 METHODS +16852 RESULTS +16853 METHODS +16854 METHODS +16855 METHODS +16856 METHODS +16857 METHODS +16858 RESULTS +16859 RESULTS +16860 CONCLUSIONS +16861 BACKGROUND +16862 BACKGROUND +16863 METHODS +16864 METHODS +16865 METHODS +16866 METHODS +16867 RESULTS +16868 RESULTS +16869 CONCLUSIONS +16870 BACKGROUND +16871 CONCLUSIONS +16872 BACKGROUND +16873 BACKGROUND +16874 OBJECTIVE +16875 METHODS +16876 METHODS +16877 METHODS +16878 RESULTS +16879 RESULTS +16880 CONCLUSIONS +16881 OBJECTIVE +16882 METHODS +16883 METHODS +16884 RESULTS +16885 METHODS +16886 METHODS +16887 METHODS +16888 METHODS +16889 METHODS +16890 RESULTS +16891 RESULTS +16892 RESULTS +16893 RESULTS +16894 RESULTS +16895 CONCLUSIONS +16896 CONCLUSIONS +16897 OBJECTIVE +16898 METHODS +16899 METHODS +16900 METHODS +16901 METHODS +16902 METHODS +16903 METHODS +16904 RESULTS +16905 RESULTS +16906 CONCLUSIONS +16907 CONCLUSIONS +16908 BACKGROUND +16909 BACKGROUND +16910 OBJECTIVE +16911 METHODS +16912 METHODS +16913 METHODS +16914 RESULTS +16915 RESULTS +16916 RESULTS +16917 CONCLUSIONS +16918 OBJECTIVE +16919 METHODS +16920 METHODS +16921 METHODS +16922 METHODS +16923 METHODS +16924 METHODS +16925 METHODS +16926 METHODS +16927 RESULTS +16928 RESULTS +16929 RESULTS +16930 CONCLUSIONS +16931 OBJECTIVE +16932 METHODS +16933 METHODS +16934 METHODS +16935 METHODS +16936 METHODS +16937 METHODS +16938 CONCLUSIONS +16939 RESULTS +16940 CONCLUSIONS +16941 BACKGROUND +16942 BACKGROUND +16943 BACKGROUND +16944 METHODS +16945 METHODS +16946 METHODS +16947 METHODS +16948 METHODS +16949 METHODS +16950 METHODS +16951 METHODS +16952 RESULTS +16953 RESULTS +16954 RESULTS +16955 RESULTS +16956 RESULTS +16957 RESULTS +16958 RESULTS +16959 RESULTS +16960 CONCLUSIONS +16961 CONCLUSIONS +16962 BACKGROUND +16963 OBJECTIVE +16964 METHODS +16965 METHODS +16966 RESULTS +16967 RESULTS +16968 CONCLUSIONS +16969 CONCLUSIONS +16970 BACKGROUND +16971 OBJECTIVE +16972 METHODS +16973 METHODS +16974 METHODS +16975 METHODS +16976 CONCLUSIONS +16977 RESULTS +16978 RESULTS +16979 RESULTS +16980 RESULTS +16981 RESULTS +16982 CONCLUSIONS +16983 CONCLUSIONS +16984 OBJECTIVE +16985 METHODS +16986 METHODS +16987 METHODS +16988 METHODS +16989 RESULTS +16990 RESULTS +16991 CONCLUSIONS +16992 OBJECTIVE +16993 OBJECTIVE +16994 METHODS +16995 METHODS +16996 METHODS +16997 METHODS +16998 METHODS +16999 METHODS +17000 METHODS +17001 METHODS +17002 RESULTS +17003 RESULTS +17004 RESULTS +17005 RESULTS +17006 CONCLUSIONS +17007 BACKGROUND +17008 METHODS +17009 METHODS +17010 METHODS +17011 METHODS +17012 RESULTS +17013 RESULTS +17014 CONCLUSIONS +17015 OBJECTIVE +17016 METHODS +17017 METHODS +17018 METHODS +17019 RESULTS +17020 METHODS +17021 RESULTS +17022 RESULTS +17023 RESULTS +17024 CONCLUSIONS +17025 CONCLUSIONS +17026 OBJECTIVE +17027 OBJECTIVE +17028 METHODS +17029 METHODS +17030 METHODS +17031 RESULTS +17032 RESULTS +17033 RESULTS +17034 RESULTS +17035 CONCLUSIONS +17036 CONCLUSIONS +17037 BACKGROUND +17038 METHODS +17039 METHODS +17040 RESULTS +17041 RESULTS +17042 RESULTS +17043 RESULTS +17044 CONCLUSIONS +17045 CONCLUSIONS +17046 RESULTS +17047 BACKGROUND +17048 BACKGROUND +17049 BACKGROUND +17050 BACKGROUND +17051 CONCLUSIONS +17052 METHODS +17053 METHODS +17054 RESULTS +17055 RESULTS +17056 RESULTS +17057 RESULTS +17058 RESULTS +17059 CONCLUSIONS +17060 CONCLUSIONS +17061 OBJECTIVE +17062 METHODS +17063 METHODS +17064 METHODS +17065 RESULTS +17066 RESULTS +17067 RESULTS +17068 RESULTS +17069 RESULTS +17070 RESULTS +17071 CONCLUSIONS +17072 RESULTS +17073 OBJECTIVE +17074 BACKGROUND +17075 OBJECTIVE +17076 METHODS +17077 METHODS +17078 METHODS +17079 RESULTS +17080 RESULTS +17081 RESULTS +17082 RESULTS +17083 CONCLUSIONS +17084 CONCLUSIONS +17085 OBJECTIVE +17086 OBJECTIVE +17087 OBJECTIVE +17088 METHODS +17089 METHODS +17090 METHODS +17091 RESULTS +17092 RESULTS +17093 CONCLUSIONS +17094 CONCLUSIONS +17095 OBJECTIVE +17096 METHODS +17097 METHODS +17098 METHODS +17099 METHODS +17100 RESULTS +17101 RESULTS +17102 RESULTS +17103 RESULTS +17104 RESULTS +17105 BACKGROUND +17106 CONCLUSIONS +17107 OBJECTIVE +17108 METHODS +17109 RESULTS +17110 RESULTS +17111 RESULTS +17112 RESULTS +17113 RESULTS +17114 CONCLUSIONS +17115 OBJECTIVE +17116 METHODS +17117 METHODS +17118 METHODS +17119 METHODS +17120 METHODS +17121 CONCLUSIONS +17122 METHODS +17123 OBJECTIVE +17124 CONCLUSIONS +17125 RESULTS +17126 RESULTS +17127 RESULTS +17128 RESULTS +17129 CONCLUSIONS +17130 CONCLUSIONS +17131 CONCLUSIONS +17132 BACKGROUND +17133 BACKGROUND +17134 OBJECTIVE +17135 METHODS +17136 METHODS +17137 RESULTS +17138 RESULTS +17139 RESULTS +17140 RESULTS +17141 RESULTS +17142 CONCLUSIONS +17143 CONCLUSIONS +17144 BACKGROUND +17145 BACKGROUND +17146 BACKGROUND +17147 BACKGROUND +17148 BACKGROUND +17149 METHODS +17150 METHODS +17151 RESULTS +17152 RESULTS +17153 CONCLUSIONS +17154 CONCLUSIONS +17155 BACKGROUND +17156 RESULTS +17157 CONCLUSIONS +17158 BACKGROUND +17159 METHODS +17160 METHODS +17161 METHODS +17162 METHODS +17163 METHODS +17164 METHODS +17165 METHODS +17166 METHODS +17167 METHODS +17168 CONCLUSIONS +17169 METHODS +17170 CONCLUSIONS +17171 BACKGROUND +17172 CONCLUSIONS +17173 OBJECTIVE +17174 METHODS +17175 METHODS +17176 METHODS +17177 CONCLUSIONS +17178 RESULTS +17179 RESULTS +17180 CONCLUSIONS +17181 RESULTS +17182 RESULTS +17183 RESULTS +17184 CONCLUSIONS +17185 CONCLUSIONS +17186 CONCLUSIONS +17187 OBJECTIVE +17188 METHODS +17189 METHODS +17190 METHODS +17191 METHODS +17192 METHODS +17193 METHODS +17194 RESULTS +17195 RESULTS +17196 RESULTS +17197 RESULTS +17198 CONCLUSIONS +17199 RESULTS +17200 RESULTS +17201 CONCLUSIONS +17202 OBJECTIVE +17203 METHODS +17204 METHODS +17205 METHODS +17206 METHODS +17207 METHODS +17208 METHODS +17209 METHODS +17210 RESULTS +17211 CONCLUSIONS +17212 BACKGROUND +17213 BACKGROUND +17214 OBJECTIVE +17215 METHODS +17216 METHODS +17217 METHODS +17218 METHODS +17219 METHODS +17220 RESULTS +17221 RESULTS +17222 CONCLUSIONS +17223 CONCLUSIONS +17224 OBJECTIVE +17225 METHODS +17226 METHODS +17227 METHODS +17228 RESULTS +17229 RESULTS +17230 METHODS +17231 CONCLUSIONS +17232 CONCLUSIONS +17233 OBJECTIVE +17234 METHODS +17235 METHODS +17236 RESULTS +17237 RESULTS +17238 RESULTS +17239 RESULTS +17240 RESULTS +17241 RESULTS +17242 CONCLUSIONS +17243 OBJECTIVE +17244 METHODS +17245 METHODS +17246 METHODS +17247 METHODS +17248 METHODS +17249 METHODS +17250 RESULTS +17251 RESULTS +17252 RESULTS +17253 CONCLUSIONS +17254 CONCLUSIONS +17255 BACKGROUND +17256 BACKGROUND +17257 METHODS +17258 RESULTS +17259 METHODS +17260 METHODS +17261 METHODS +17262 RESULTS +17263 RESULTS +17264 RESULTS +17265 RESULTS +17266 RESULTS +17267 CONCLUSIONS +17268 OBJECTIVE +17269 METHODS +17270 METHODS +17271 METHODS +17272 RESULTS +17273 RESULTS +17274 RESULTS +17275 RESULTS +17276 RESULTS +17277 RESULTS +17278 CONCLUSIONS +17279 CONCLUSIONS +17280 OBJECTIVE +17281 METHODS +17282 METHODS +17283 METHODS +17284 METHODS +17285 RESULTS +17286 RESULTS +17287 CONCLUSIONS +17288 CONCLUSIONS +17289 OBJECTIVE +17290 METHODS +17291 METHODS +17292 METHODS +17293 METHODS +17294 RESULTS +17295 RESULTS +17296 RESULTS +17297 CONCLUSIONS +17298 OBJECTIVE +17299 METHODS +17300 METHODS +17301 METHODS +17302 METHODS +17303 RESULTS +17304 RESULTS +17305 RESULTS +17306 RESULTS +17307 RESULTS +17308 RESULTS +17309 RESULTS +17310 BACKGROUND +17311 CONCLUSIONS +17312 BACKGROUND +17313 METHODS +17314 METHODS +17315 RESULTS +17316 RESULTS +17317 RESULTS +17318 RESULTS +17319 CONCLUSIONS +17320 CONCLUSIONS +17321 OBJECTIVE +17322 METHODS +17323 METHODS +17324 METHODS +17325 METHODS +17326 METHODS +17327 METHODS +17328 RESULTS +17329 RESULTS +17330 RESULTS +17331 RESULTS +17332 CONCLUSIONS +17333 BACKGROUND +17334 BACKGROUND +17335 METHODS +17336 METHODS +17337 METHODS +17338 RESULTS +17339 RESULTS +17340 CONCLUSIONS +17341 BACKGROUND +17342 CONCLUSIONS +17343 BACKGROUND +17344 BACKGROUND +17345 BACKGROUND +17346 METHODS +17347 METHODS +17348 METHODS +17349 METHODS +17350 RESULTS +17351 RESULTS +17352 RESULTS +17353 RESULTS +17354 CONCLUSIONS +17355 RESULTS +17356 BACKGROUND +17357 BACKGROUND +17358 OBJECTIVE +17359 METHODS +17360 METHODS +17361 METHODS +17362 RESULTS +17363 RESULTS +17364 RESULTS +17365 CONCLUSIONS +17366 OBJECTIVE +17367 METHODS +17368 METHODS +17369 METHODS +17370 RESULTS +17371 RESULTS +17372 RESULTS +17373 CONCLUSIONS +17374 CONCLUSIONS +17375 BACKGROUND +17376 BACKGROUND +17377 METHODS +17378 METHODS +17379 RESULTS +17380 RESULTS +17381 BACKGROUND +17382 BACKGROUND +17383 OBJECTIVE +17384 METHODS +17385 METHODS +17386 METHODS +17387 RESULTS +17388 RESULTS +17389 CONCLUSIONS +17390 OBJECTIVE +17391 METHODS +17392 METHODS +17393 METHODS +17394 METHODS +17395 RESULTS +17396 CONCLUSIONS +17397 CONCLUSIONS +17398 BACKGROUND +17399 BACKGROUND +17400 OBJECTIVE +17401 METHODS +17402 METHODS +17403 RESULTS +17404 RESULTS +17405 RESULTS +17406 RESULTS +17407 CONCLUSIONS +17408 OBJECTIVE +17409 METHODS +17410 METHODS +17411 METHODS +17412 METHODS +17413 RESULTS +17414 METHODS +17415 METHODS +17416 RESULTS +17417 RESULTS +17418 RESULTS +17419 CONCLUSIONS +17420 CONCLUSIONS +17421 BACKGROUND +17422 CONCLUSIONS +17423 OBJECTIVE +17424 METHODS +17425 METHODS +17426 METHODS +17427 METHODS +17428 METHODS +17429 METHODS +17430 METHODS +17431 METHODS +17432 METHODS +17433 RESULTS +17434 RESULTS +17435 RESULTS +17436 RESULTS +17437 CONCLUSIONS +17438 RESULTS +17439 BACKGROUND +17440 BACKGROUND +17441 METHODS +17442 METHODS +17443 RESULTS +17444 METHODS +17445 METHODS +17446 RESULTS +17447 RESULTS +17448 RESULTS +17449 RESULTS +17450 RESULTS +17451 CONCLUSIONS +17452 CONCLUSIONS +17453 CONCLUSIONS +17454 BACKGROUND +17455 BACKGROUND +17456 BACKGROUND +17457 METHODS +17458 RESULTS +17459 RESULTS +17460 RESULTS +17461 RESULTS +17462 CONCLUSIONS +17463 CONCLUSIONS +17464 CONCLUSIONS +17465 OBJECTIVE +17466 METHODS +17467 METHODS +17468 CONCLUSIONS +17469 RESULTS +17470 RESULTS +17471 BACKGROUND +17472 RESULTS +17473 OBJECTIVE +17474 METHODS +17475 METHODS +17476 METHODS +17477 METHODS +17478 METHODS +17479 METHODS +17480 METHODS +17481 METHODS +17482 METHODS +17483 RESULTS +17484 RESULTS +17485 RESULTS +17486 RESULTS +17487 RESULTS +17488 RESULTS +17489 CONCLUSIONS +17490 CONCLUSIONS +17491 CONCLUSIONS +17492 CONCLUSIONS +17493 BACKGROUND +17494 BACKGROUND +17495 BACKGROUND +17496 METHODS +17497 METHODS +17498 METHODS +17499 METHODS +17500 METHODS +17501 METHODS +17502 RESULTS +17503 RESULTS +17504 RESULTS +17505 RESULTS +17506 RESULTS +17507 RESULTS +17508 CONCLUSIONS +17509 CONCLUSIONS +17510 BACKGROUND +17511 CONCLUSIONS +17512 METHODS +17513 METHODS +17514 METHODS +17515 METHODS +17516 METHODS +17517 METHODS +17518 METHODS +17519 METHODS +17520 METHODS +17521 METHODS +17522 METHODS +17523 METHODS +17524 BACKGROUND +17525 BACKGROUND +17526 BACKGROUND +17527 CONCLUSIONS +17528 BACKGROUND +17529 BACKGROUND +17530 OBJECTIVE +17531 METHODS +17532 METHODS +17533 METHODS +17534 CONCLUSIONS +17535 RESULTS +17536 CONCLUSIONS +17537 CONCLUSIONS +17538 CONCLUSIONS +17539 CONCLUSIONS +17540 OBJECTIVE +17541 METHODS +17542 METHODS +17543 METHODS +17544 METHODS +17545 METHODS +17546 RESULTS +17547 RESULTS +17548 RESULTS +17549 CONCLUSIONS +17550 BACKGROUND +17551 BACKGROUND +17552 METHODS +17553 METHODS +17554 METHODS +17555 METHODS +17556 RESULTS +17557 CONCLUSIONS +17558 BACKGROUND +17559 BACKGROUND +17560 OBJECTIVE +17561 METHODS +17562 METHODS +17563 RESULTS +17564 RESULTS +17565 CONCLUSIONS +17566 OBJECTIVE +17567 METHODS +17568 METHODS +17569 METHODS +17570 METHODS +17571 METHODS +17572 RESULTS +17573 RESULTS +17574 RESULTS +17575 CONCLUSIONS +17576 BACKGROUND +17577 BACKGROUND +17578 METHODS +17579 METHODS +17580 METHODS +17581 METHODS +17582 RESULTS +17583 RESULTS +17584 RESULTS +17585 RESULTS +17586 RESULTS +17587 RESULTS +17588 RESULTS +17589 CONCLUSIONS +17590 BACKGROUND +17591 METHODS +17592 METHODS +17593 RESULTS +17594 RESULTS +17595 RESULTS +17596 CONCLUSIONS +17597 BACKGROUND +17598 BACKGROUND +17599 OBJECTIVE +17600 METHODS +17601 METHODS +17602 METHODS +17603 RESULTS +17604 RESULTS +17605 RESULTS +17606 RESULTS +17607 RESULTS +17608 CONCLUSIONS +17609 CONCLUSIONS +17610 CONCLUSIONS +17611 BACKGROUND +17612 OBJECTIVE +17613 METHODS +17614 METHODS +17615 METHODS +17616 METHODS +17617 RESULTS +17618 RESULTS +17619 RESULTS +17620 RESULTS +17621 RESULTS +17622 RESULTS +17623 CONCLUSIONS +17624 OBJECTIVE +17625 METHODS +17626 METHODS +17627 METHODS +17628 RESULTS +17629 RESULTS +17630 RESULTS +17631 RESULTS +17632 RESULTS +17633 RESULTS +17634 RESULTS +17635 RESULTS +17636 CONCLUSIONS +17637 OBJECTIVE +17638 METHODS +17639 METHODS +17640 METHODS +17641 METHODS +17642 METHODS +17643 METHODS +17644 METHODS +17645 RESULTS +17646 RESULTS +17647 RESULTS +17648 RESULTS +17649 CONCLUSIONS +17650 BACKGROUND +17651 BACKGROUND +17652 BACKGROUND +17653 BACKGROUND +17654 METHODS +17655 METHODS +17656 METHODS +17657 METHODS +17658 METHODS +17659 CONCLUSIONS +17660 BACKGROUND +17661 BACKGROUND +17662 METHODS +17663 METHODS +17664 METHODS +17665 METHODS +17666 RESULTS +17667 RESULTS +17668 RESULTS +17669 RESULTS +17670 CONCLUSIONS +17671 RESULTS +17672 CONCLUSIONS +17673 BACKGROUND +17674 RESULTS +17675 METHODS +17676 METHODS +17677 RESULTS +17678 RESULTS +17679 RESULTS +17680 BACKGROUND +17681 CONCLUSIONS +17682 BACKGROUND +17683 OBJECTIVE +17684 METHODS +17685 METHODS +17686 METHODS +17687 RESULTS +17688 RESULTS +17689 RESULTS +17690 CONCLUSIONS +17691 CONCLUSIONS +17692 BACKGROUND +17693 BACKGROUND +17694 OBJECTIVE +17695 RESULTS +17696 METHODS +17697 METHODS +17698 RESULTS +17699 RESULTS +17700 RESULTS +17701 CONCLUSIONS +17702 CONCLUSIONS +17703 OBJECTIVE +17704 METHODS +17705 METHODS +17706 RESULTS +17707 CONCLUSIONS +17708 BACKGROUND +17709 BACKGROUND +17710 METHODS +17711 METHODS +17712 RESULTS +17713 RESULTS +17714 RESULTS +17715 RESULTS +17716 RESULTS +17717 CONCLUSIONS +17718 CONCLUSIONS +17719 BACKGROUND +17720 BACKGROUND +17721 BACKGROUND +17722 BACKGROUND +17723 BACKGROUND +17724 METHODS +17725 METHODS +17726 METHODS +17727 METHODS +17728 METHODS +17729 METHODS +17730 BACKGROUND +17731 CONCLUSIONS +17732 BACKGROUND +17733 BACKGROUND +17734 OBJECTIVE +17735 METHODS +17736 METHODS +17737 RESULTS +17738 RESULTS +17739 RESULTS +17740 RESULTS +17741 CONCLUSIONS +17742 BACKGROUND +17743 METHODS +17744 RESULTS +17745 RESULTS +17746 RESULTS +17747 RESULTS +17748 RESULTS +17749 CONCLUSIONS +17750 CONCLUSIONS +17751 OBJECTIVE +17752 METHODS +17753 RESULTS +17754 RESULTS +17755 RESULTS +17756 RESULTS +17757 RESULTS +17758 CONCLUSIONS +17759 BACKGROUND +17760 METHODS +17761 METHODS +17762 BACKGROUND +17763 METHODS +17764 METHODS +17765 METHODS +17766 METHODS +17767 METHODS +17768 METHODS +17769 CONCLUSIONS +17770 CONCLUSIONS +17771 BACKGROUND +17772 BACKGROUND +17773 OBJECTIVE +17774 OBJECTIVE +17775 METHODS +17776 METHODS +17777 METHODS +17778 METHODS +17779 RESULTS +17780 RESULTS +17781 RESULTS +17782 RESULTS +17783 CONCLUSIONS +17784 CONCLUSIONS +17785 BACKGROUND +17786 METHODS +17787 METHODS +17788 METHODS +17789 METHODS +17790 METHODS +17791 RESULTS +17792 RESULTS +17793 RESULTS +17794 RESULTS +17795 CONCLUSIONS +17796 OBJECTIVE +17797 METHODS +17798 METHODS +17799 RESULTS +17800 METHODS +17801 RESULTS +17802 METHODS +17803 METHODS +17804 METHODS +17805 RESULTS +17806 RESULTS +17807 RESULTS +17808 RESULTS +17809 RESULTS +17810 CONCLUSIONS +17811 CONCLUSIONS +17812 OBJECTIVE +17813 METHODS +17814 METHODS +17815 RESULTS +17816 RESULTS +17817 BACKGROUND +17818 BACKGROUND +17819 OBJECTIVE +17820 METHODS +17821 METHODS +17822 METHODS +17823 METHODS +17824 METHODS +17825 RESULTS +17826 RESULTS +17827 RESULTS +17828 RESULTS +17829 RESULTS +17830 CONCLUSIONS +17831 CONCLUSIONS +17832 BACKGROUND +17833 BACKGROUND +17834 OBJECTIVE +17835 METHODS +17836 METHODS +17837 RESULTS +17838 RESULTS +17839 CONCLUSIONS +17840 BACKGROUND +17841 CONCLUSIONS +17842 CONCLUSIONS +17843 BACKGROUND +17844 BACKGROUND +17845 BACKGROUND +17846 METHODS +17847 METHODS +17848 METHODS +17849 METHODS +17850 METHODS +17851 RESULTS +17852 RESULTS +17853 RESULTS +17854 CONCLUSIONS +17855 CONCLUSIONS +17856 CONCLUSIONS +17857 OBJECTIVE +17858 METHODS +17859 METHODS +17860 METHODS +17861 METHODS +17862 METHODS +17863 METHODS +17864 RESULTS +17865 RESULTS +17866 CONCLUSIONS +17867 OBJECTIVE +17868 METHODS +17869 METHODS +17870 METHODS +17871 METHODS +17872 RESULTS +17873 RESULTS +17874 RESULTS +17875 RESULTS +17876 CONCLUSIONS +17877 OBJECTIVE +17878 OBJECTIVE +17879 METHODS +17880 METHODS +17881 METHODS +17882 METHODS +17883 METHODS +17884 METHODS +17885 METHODS +17886 RESULTS +17887 RESULTS +17888 RESULTS +17889 RESULTS +17890 RESULTS +17891 RESULTS +17892 RESULTS +17893 RESULTS +17894 RESULTS +17895 CONCLUSIONS +17896 CONCLUSIONS +17897 OBJECTIVE +17898 METHODS +17899 METHODS +17900 METHODS +17901 METHODS +17902 METHODS +17903 METHODS +17904 RESULTS +17905 RESULTS +17906 RESULTS +17907 RESULTS +17908 RESULTS +17909 RESULTS +17910 RESULTS +17911 CONCLUSIONS +17912 BACKGROUND +17913 METHODS +17914 OBJECTIVE +17915 RESULTS +17916 RESULTS +17917 RESULTS +17918 CONCLUSIONS +17919 OBJECTIVE +17920 METHODS +17921 BACKGROUND +17922 CONCLUSIONS +17923 METHODS +17924 RESULTS +17925 RESULTS +17926 RESULTS +17927 CONCLUSIONS +17928 RESULTS +17929 RESULTS +17930 RESULTS +17931 RESULTS +17932 CONCLUSIONS +17933 CONCLUSIONS +17934 OBJECTIVE +17935 OBJECTIVE +17936 METHODS +17937 METHODS +17938 METHODS +17939 RESULTS +17940 RESULTS +17941 RESULTS +17942 RESULTS +17943 CONCLUSIONS +17944 BACKGROUND +17945 BACKGROUND +17946 BACKGROUND +17947 METHODS +17948 METHODS +17949 METHODS +17950 METHODS +17951 RESULTS +17952 RESULTS +17953 RESULTS +17954 RESULTS +17955 CONCLUSIONS +17956 BACKGROUND +17957 BACKGROUND +17958 OBJECTIVE +17959 METHODS +17960 METHODS +17961 CONCLUSIONS +17962 CONCLUSIONS +17963 CONCLUSIONS +17964 BACKGROUND +17965 BACKGROUND +17966 BACKGROUND +17967 METHODS +17968 METHODS +17969 METHODS +17970 METHODS +17971 RESULTS +17972 RESULTS +17973 RESULTS +17974 RESULTS +17975 CONCLUSIONS +17976 CONCLUSIONS +17977 BACKGROUND +17978 CONCLUSIONS +17979 OBJECTIVE +17980 METHODS +17981 METHODS +17982 RESULTS +17983 RESULTS +17984 RESULTS +17985 RESULTS +17986 OBJECTIVE +17987 METHODS +17988 METHODS +17989 METHODS +17990 METHODS +17991 RESULTS +17992 RESULTS +17993 RESULTS +17994 RESULTS +17995 RESULTS +17996 CONCLUSIONS +17997 OBJECTIVE +17998 METHODS +17999 METHODS +18000 METHODS +18001 METHODS +18002 RESULTS +18003 RESULTS +18004 RESULTS +18005 RESULTS +18006 CONCLUSIONS +18007 CONCLUSIONS +18008 CONCLUSIONS +18009 BACKGROUND +18010 OBJECTIVE +18011 OBJECTIVE +18012 METHODS +18013 METHODS +18014 METHODS +18015 METHODS +18016 RESULTS +18017 RESULTS +18018 CONCLUSIONS +18019 BACKGROUND +18020 BACKGROUND +18021 OBJECTIVE +18022 METHODS +18023 METHODS +18024 METHODS +18025 METHODS +18026 RESULTS +18027 RESULTS +18028 CONCLUSIONS +18029 CONCLUSIONS +18030 OBJECTIVE +18031 METHODS +18032 METHODS +18033 METHODS +18034 METHODS +18035 METHODS +18036 RESULTS +18037 CONCLUSIONS +18038 OBJECTIVE +18039 METHODS +18040 METHODS +18041 METHODS +18042 METHODS +18043 METHODS +18044 RESULTS +18045 RESULTS +18046 CONCLUSIONS +18047 CONCLUSIONS +18048 BACKGROUND +18049 METHODS +18050 METHODS +18051 METHODS +18052 METHODS +18053 METHODS +18054 METHODS +18055 METHODS +18056 RESULTS +18057 RESULTS +18058 RESULTS +18059 RESULTS +18060 CONCLUSIONS +18061 BACKGROUND +18062 BACKGROUND +18063 OBJECTIVE +18064 METHODS +18065 METHODS +18066 METHODS +18067 RESULTS +18068 RESULTS +18069 RESULTS +18070 RESULTS +18071 CONCLUSIONS +18072 OBJECTIVE +18073 METHODS +18074 METHODS +18075 RESULTS +18076 RESULTS +18077 RESULTS +18078 RESULTS +18079 RESULTS +18080 RESULTS +18081 CONCLUSIONS +18082 CONCLUSIONS +18083 OBJECTIVE +18084 BACKGROUND +18085 BACKGROUND +18086 RESULTS +18087 RESULTS +18088 METHODS +18089 METHODS +18090 RESULTS +18091 RESULTS +18092 RESULTS +18093 RESULTS +18094 RESULTS +18095 RESULTS +18096 CONCLUSIONS +18097 BACKGROUND +18098 BACKGROUND +18099 BACKGROUND +18100 BACKGROUND +18101 METHODS +18102 METHODS +18103 METHODS +18104 OBJECTIVE +18105 OBJECTIVE +18106 RESULTS +18107 RESULTS +18108 CONCLUSIONS +18109 CONCLUSIONS +18110 BACKGROUND +18111 OBJECTIVE +18112 METHODS +18113 RESULTS +18114 RESULTS +18115 RESULTS +18116 RESULTS +18117 CONCLUSIONS +18118 BACKGROUND +18119 BACKGROUND +18120 OBJECTIVE +18121 METHODS +18122 METHODS +18123 RESULTS +18124 RESULTS +18125 CONCLUSIONS +18126 CONCLUSIONS +18127 OBJECTIVE +18128 METHODS +18129 METHODS +18130 METHODS +18131 METHODS +18132 METHODS +18133 METHODS +18134 RESULTS +18135 RESULTS +18136 RESULTS +18137 RESULTS +18138 RESULTS +18139 CONCLUSIONS +18140 RESULTS +18141 RESULTS +18142 CONCLUSIONS +18143 CONCLUSIONS +18144 BACKGROUND +18145 OBJECTIVE +18146 METHODS +18147 METHODS +18148 METHODS +18149 METHODS +18150 METHODS +18151 METHODS +18152 METHODS +18153 RESULTS +18154 RESULTS +18155 CONCLUSIONS +18156 OBJECTIVE +18157 METHODS +18158 METHODS +18159 METHODS +18160 METHODS +18161 METHODS +18162 RESULTS +18163 RESULTS +18164 RESULTS +18165 RESULTS +18166 RESULTS +18167 CONCLUSIONS +18168 BACKGROUND +18169 OBJECTIVE +18170 METHODS +18171 METHODS +18172 METHODS +18173 RESULTS +18174 RESULTS +18175 RESULTS +18176 RESULTS +18177 CONCLUSIONS +18178 OBJECTIVE +18179 METHODS +18180 METHODS +18181 METHODS +18182 METHODS +18183 METHODS +18184 METHODS +18185 RESULTS +18186 RESULTS +18187 RESULTS +18188 RESULTS +18189 RESULTS +18190 RESULTS +18191 RESULTS +18192 RESULTS +18193 CONCLUSIONS +18194 OBJECTIVE +18195 METHODS +18196 METHODS +18197 METHODS +18198 RESULTS +18199 RESULTS +18200 RESULTS +18201 RESULTS +18202 RESULTS +18203 CONCLUSIONS +18204 CONCLUSIONS +18205 CONCLUSIONS +18206 BACKGROUND +18207 BACKGROUND +18208 METHODS +18209 RESULTS +18210 RESULTS +18211 CONCLUSIONS +18212 BACKGROUND +18213 OBJECTIVE +18214 METHODS +18215 METHODS +18216 METHODS +18217 METHODS +18218 METHODS +18219 RESULTS +18220 RESULTS +18221 RESULTS +18222 CONCLUSIONS +18223 CONCLUSIONS +18224 OBJECTIVE +18225 METHODS +18226 METHODS +18227 METHODS +18228 METHODS +18229 METHODS +18230 RESULTS +18231 RESULTS +18232 CONCLUSIONS +18233 OBJECTIVE +18234 BACKGROUND +18235 BACKGROUND +18236 METHODS +18237 METHODS +18238 METHODS +18239 RESULTS +18240 RESULTS +18241 CONCLUSIONS +18242 CONCLUSIONS +18243 BACKGROUND +18244 OBJECTIVE +18245 OBJECTIVE +18246 METHODS +18247 METHODS +18248 METHODS +18249 RESULTS +18250 RESULTS +18251 RESULTS +18252 CONCLUSIONS +18253 BACKGROUND +18254 OBJECTIVE +18255 METHODS +18256 METHODS +18257 METHODS +18258 RESULTS +18259 RESULTS +18260 RESULTS +18261 CONCLUSIONS +18262 CONCLUSIONS +18263 OBJECTIVE +18264 METHODS +18265 METHODS +18266 METHODS +18267 METHODS +18268 RESULTS +18269 METHODS +18270 RESULTS +18271 RESULTS +18272 RESULTS +18273 RESULTS +18274 RESULTS +18275 CONCLUSIONS +18276 OBJECTIVE +18277 RESULTS +18278 BACKGROUND +18279 METHODS +18280 RESULTS +18281 METHODS +18282 METHODS +18283 METHODS +18284 METHODS +18285 METHODS +18286 METHODS +18287 METHODS +18288 RESULTS +18289 RESULTS +18290 RESULTS +18291 RESULTS +18292 RESULTS +18293 RESULTS +18294 RESULTS +18295 RESULTS +18296 CONCLUSIONS +18297 BACKGROUND +18298 METHODS +18299 METHODS +18300 METHODS +18301 METHODS +18302 METHODS +18303 RESULTS +18304 RESULTS +18305 RESULTS +18306 RESULTS +18307 RESULTS +18308 CONCLUSIONS +18309 OBJECTIVE +18310 METHODS +18311 METHODS +18312 METHODS +18313 METHODS +18314 RESULTS +18315 RESULTS +18316 RESULTS +18317 CONCLUSIONS +18318 RESULTS +18319 OBJECTIVE +18320 METHODS +18321 METHODS +18322 RESULTS +18323 RESULTS +18324 CONCLUSIONS +18325 BACKGROUND +18326 OBJECTIVE +18327 METHODS +18328 METHODS +18329 RESULTS +18330 RESULTS +18331 CONCLUSIONS +18332 RESULTS +18333 OBJECTIVE +18334 METHODS +18335 METHODS +18336 RESULTS +18337 RESULTS +18338 RESULTS +18339 RESULTS +18340 RESULTS +18341 CONCLUSIONS +18342 OBJECTIVE +18343 METHODS +18344 METHODS +18345 METHODS +18346 METHODS +18347 METHODS +18348 RESULTS +18349 RESULTS +18350 RESULTS +18351 CONCLUSIONS +18352 BACKGROUND +18353 OBJECTIVE +18354 METHODS +18355 METHODS +18356 METHODS +18357 METHODS +18358 RESULTS +18359 RESULTS +18360 RESULTS +18361 RESULTS +18362 CONCLUSIONS +18363 BACKGROUND +18364 BACKGROUND +18365 BACKGROUND +18366 BACKGROUND +18367 BACKGROUND +18368 METHODS +18369 METHODS +18370 METHODS +18371 METHODS +18372 METHODS +18373 METHODS +18374 METHODS +18375 BACKGROUND +18376 METHODS +18377 METHODS +18378 RESULTS +18379 RESULTS +18380 RESULTS +18381 RESULTS +18382 CONCLUSIONS +18383 OBJECTIVE +18384 METHODS +18385 METHODS +18386 METHODS +18387 METHODS +18388 METHODS +18389 METHODS +18390 METHODS +18391 METHODS +18392 METHODS +18393 RESULTS +18394 RESULTS +18395 RESULTS +18396 RESULTS +18397 RESULTS +18398 CONCLUSIONS +18399 CONCLUSIONS +18400 CONCLUSIONS +18401 BACKGROUND +18402 BACKGROUND +18403 BACKGROUND +18404 OBJECTIVE +18405 METHODS +18406 METHODS +18407 METHODS +18408 RESULTS +18409 RESULTS +18410 RESULTS +18411 RESULTS +18412 RESULTS +18413 RESULTS +18414 RESULTS +18415 RESULTS +18416 RESULTS +18417 RESULTS +18418 CONCLUSIONS +18419 CONCLUSIONS +18420 OBJECTIVE +18421 METHODS +18422 METHODS +18423 METHODS +18424 METHODS +18425 METHODS +18426 RESULTS +18427 RESULTS +18428 CONCLUSIONS +18429 CONCLUSIONS +18430 BACKGROUND +18431 METHODS +18432 METHODS +18433 RESULTS +18434 RESULTS +18435 CONCLUSIONS +18436 RESULTS +18437 RESULTS +18438 CONCLUSIONS +18439 CONCLUSIONS +18440 RESULTS +18441 BACKGROUND +18442 BACKGROUND +18443 METHODS +18444 METHODS +18445 METHODS +18446 RESULTS +18447 RESULTS +18448 RESULTS +18449 RESULTS +18450 RESULTS +18451 RESULTS +18452 CONCLUSIONS +18453 BACKGROUND +18454 CONCLUSIONS +18455 BACKGROUND +18456 OBJECTIVE +18457 METHODS +18458 METHODS +18459 RESULTS +18460 RESULTS +18461 RESULTS +18462 RESULTS +18463 CONCLUSIONS +18464 BACKGROUND +18465 BACKGROUND +18466 BACKGROUND +18467 BACKGROUND +18468 METHODS +18469 METHODS +18470 METHODS +18471 RESULTS +18472 RESULTS +18473 RESULTS +18474 RESULTS +18475 RESULTS +18476 CONCLUSIONS +18477 CONCLUSIONS +18478 OBJECTIVE +18479 METHODS +18480 METHODS +18481 METHODS +18482 METHODS +18483 METHODS +18484 METHODS +18485 METHODS +18486 RESULTS +18487 RESULTS +18488 CONCLUSIONS +18489 BACKGROUND +18490 BACKGROUND +18491 CONCLUSIONS +18492 BACKGROUND +18493 METHODS +18494 METHODS +18495 METHODS +18496 METHODS +18497 CONCLUSIONS +18498 CONCLUSIONS +18499 BACKGROUND +18500 BACKGROUND +18501 BACKGROUND +18502 OBJECTIVE +18503 BACKGROUND +18504 METHODS +18505 METHODS +18506 METHODS +18507 RESULTS +18508 RESULTS +18509 RESULTS +18510 CONCLUSIONS +18511 OBJECTIVE +18512 METHODS +18513 METHODS +18514 METHODS +18515 RESULTS +18516 RESULTS +18517 RESULTS +18518 RESULTS +18519 CONCLUSIONS +18520 RESULTS +18521 BACKGROUND +18522 BACKGROUND +18523 OBJECTIVE +18524 METHODS +18525 METHODS +18526 METHODS +18527 RESULTS +18528 RESULTS +18529 RESULTS +18530 CONCLUSIONS +18531 CONCLUSIONS +18532 BACKGROUND +18533 BACKGROUND +18534 METHODS +18535 METHODS +18536 METHODS +18537 METHODS +18538 METHODS +18539 RESULTS +18540 RESULTS +18541 RESULTS +18542 RESULTS +18543 RESULTS +18544 RESULTS +18545 CONCLUSIONS +18546 RESULTS +18547 CONCLUSIONS +18548 BACKGROUND +18549 BACKGROUND +18550 OBJECTIVE +18551 METHODS +18552 METHODS +18553 METHODS +18554 METHODS +18555 METHODS +18556 RESULTS +18557 RESULTS +18558 RESULTS +18559 RESULTS +18560 RESULTS +18561 RESULTS +18562 CONCLUSIONS +18563 BACKGROUND +18564 BACKGROUND +18565 METHODS +18566 METHODS +18567 RESULTS +18568 RESULTS +18569 RESULTS +18570 RESULTS +18571 RESULTS +18572 RESULTS +18573 RESULTS +18574 RESULTS +18575 RESULTS +18576 CONCLUSIONS +18577 OBJECTIVE +18578 METHODS +18579 METHODS +18580 METHODS +18581 METHODS +18582 METHODS +18583 RESULTS +18584 RESULTS +18585 RESULTS +18586 RESULTS +18587 CONCLUSIONS +18588 OBJECTIVE +18589 METHODS +18590 METHODS +18591 METHODS +18592 METHODS +18593 METHODS +18594 METHODS +18595 METHODS +18596 METHODS +18597 RESULTS +18598 RESULTS +18599 RESULTS +18600 CONCLUSIONS +18601 CONCLUSIONS +18602 OBJECTIVE +18603 METHODS +18604 METHODS +18605 METHODS +18606 RESULTS +18607 RESULTS +18608 CONCLUSIONS +18609 BACKGROUND +18610 CONCLUSIONS +18611 METHODS +18612 METHODS +18613 METHODS +18614 METHODS +18615 METHODS +18616 METHODS +18617 RESULTS +18618 BACKGROUND +18619 RESULTS +18620 BACKGROUND +18621 CONCLUSIONS +18622 CONCLUSIONS +18623 BACKGROUND +18624 OBJECTIVE +18625 METHODS +18626 METHODS +18627 METHODS +18628 METHODS +18629 RESULTS +18630 RESULTS +18631 CONCLUSIONS +18632 CONCLUSIONS +18633 BACKGROUND +18634 BACKGROUND +18635 OBJECTIVE +18636 METHODS +18637 METHODS +18638 RESULTS +18639 RESULTS +18640 RESULTS +18641 RESULTS +18642 RESULTS +18643 BACKGROUND +18644 OBJECTIVE +18645 METHODS +18646 METHODS +18647 METHODS +18648 METHODS +18649 METHODS +18650 RESULTS +18651 RESULTS +18652 RESULTS +18653 RESULTS +18654 RESULTS +18655 RESULTS +18656 CONCLUSIONS +18657 BACKGROUND +18658 CONCLUSIONS +18659 OBJECTIVE +18660 METHODS +18661 METHODS +18662 METHODS +18663 RESULTS +18664 RESULTS +18665 RESULTS +18666 CONCLUSIONS +18667 RESULTS +18668 OBJECTIVE +18669 METHODS +18670 METHODS +18671 METHODS +18672 METHODS +18673 METHODS +18674 RESULTS +18675 RESULTS +18676 CONCLUSIONS +18677 BACKGROUND +18678 OBJECTIVE +18679 BACKGROUND +18680 METHODS +18681 METHODS +18682 METHODS +18683 RESULTS +18684 RESULTS +18685 RESULTS +18686 RESULTS +18687 RESULTS +18688 RESULTS +18689 CONCLUSIONS +18690 BACKGROUND +18691 CONCLUSIONS +18692 OBJECTIVE +18693 METHODS +18694 METHODS +18695 RESULTS +18696 RESULTS +18697 RESULTS +18698 RESULTS +18699 CONCLUSIONS +18700 BACKGROUND +18701 BACKGROUND +18702 OBJECTIVE +18703 METHODS +18704 METHODS +18705 METHODS +18706 METHODS +18707 METHODS +18708 METHODS +18709 METHODS +18710 RESULTS +18711 RESULTS +18712 RESULTS +18713 CONCLUSIONS +18714 CONCLUSIONS +18715 BACKGROUND +18716 OBJECTIVE +18717 METHODS +18718 METHODS +18719 METHODS +18720 METHODS +18721 RESULTS +18722 RESULTS +18723 RESULTS +18724 CONCLUSIONS +18725 RESULTS +18726 CONCLUSIONS +18727 OBJECTIVE +18728 METHODS +18729 METHODS +18730 RESULTS +18731 RESULTS +18732 RESULTS +18733 CONCLUSIONS +18734 CONCLUSIONS +18735 OBJECTIVE +18736 METHODS +18737 METHODS +18738 METHODS +18739 METHODS +18740 METHODS +18741 RESULTS +18742 RESULTS +18743 RESULTS +18744 RESULTS +18745 RESULTS +18746 RESULTS +18747 CONCLUSIONS +18748 BACKGROUND +18749 BACKGROUND +18750 OBJECTIVE +18751 METHODS +18752 METHODS +18753 METHODS +18754 METHODS +18755 RESULTS +18756 RESULTS +18757 RESULTS +18758 RESULTS +18759 RESULTS +18760 CONCLUSIONS +18761 RESULTS +18762 RESULTS +18763 OBJECTIVE +18764 METHODS +18765 METHODS +18766 RESULTS +18767 RESULTS +18768 RESULTS +18769 RESULTS +18770 RESULTS +18771 RESULTS +18772 RESULTS +18773 RESULTS +18774 CONCLUSIONS +18775 OBJECTIVE +18776 METHODS +18777 METHODS +18778 METHODS +18779 METHODS +18780 METHODS +18781 METHODS +18782 METHODS +18783 METHODS +18784 RESULTS +18785 CONCLUSIONS +18786 BACKGROUND +18787 BACKGROUND +18788 OBJECTIVE +18789 METHODS +18790 METHODS +18791 RESULTS +18792 RESULTS +18793 RESULTS +18794 RESULTS +18795 RESULTS +18796 CONCLUSIONS +18797 CONCLUSIONS +18798 BACKGROUND +18799 OBJECTIVE +18800 METHODS +18801 METHODS +18802 METHODS +18803 METHODS +18804 METHODS +18805 RESULTS +18806 RESULTS +18807 RESULTS +18808 CONCLUSIONS +18809 CONCLUSIONS +18810 METHODS +18811 OBJECTIVE +18812 METHODS +18813 METHODS +18814 METHODS +18815 RESULTS +18816 RESULTS +18817 RESULTS +18818 CONCLUSIONS +18819 OBJECTIVE +18820 METHODS +18821 METHODS +18822 RESULTS +18823 RESULTS +18824 CONCLUSIONS +18825 CONCLUSIONS +18826 OBJECTIVE +18827 METHODS +18828 METHODS +18829 METHODS +18830 METHODS +18831 METHODS +18832 METHODS +18833 RESULTS +18834 RESULTS +18835 RESULTS +18836 CONCLUSIONS +18837 RESULTS +18838 BACKGROUND +18839 BACKGROUND +18840 BACKGROUND +18841 METHODS +18842 RESULTS +18843 RESULTS +18844 RESULTS +18845 RESULTS +18846 RESULTS +18847 RESULTS +18848 RESULTS +18849 CONCLUSIONS +18850 CONCLUSIONS +18851 BACKGROUND +18852 OBJECTIVE +18853 METHODS +18854 METHODS +18855 METHODS +18856 METHODS +18857 RESULTS +18858 RESULTS +18859 RESULTS +18860 RESULTS +18861 RESULTS +18862 RESULTS +18863 CONCLUSIONS +18864 RESULTS +18865 CONCLUSIONS +18866 BACKGROUND +18867 BACKGROUND +18868 BACKGROUND +18869 BACKGROUND +18870 METHODS +18871 METHODS +18872 METHODS +18873 CONCLUSIONS +18874 RESULTS +18875 CONCLUSIONS +18876 BACKGROUND +18877 BACKGROUND +18878 METHODS +18879 METHODS +18880 METHODS +18881 METHODS +18882 RESULTS +18883 RESULTS +18884 RESULTS +18885 RESULTS +18886 RESULTS +18887 RESULTS +18888 CONCLUSIONS +18889 CONCLUSIONS +18890 BACKGROUND +18891 METHODS +18892 METHODS +18893 METHODS +18894 METHODS +18895 METHODS +18896 RESULTS +18897 RESULTS +18898 RESULTS +18899 CONCLUSIONS +18900 CONCLUSIONS +18901 BACKGROUND +18902 CONCLUSIONS +18903 OBJECTIVE +18904 METHODS +18905 METHODS +18906 METHODS +18907 METHODS +18908 RESULTS +18909 RESULTS +18910 RESULTS +18911 RESULTS +18912 RESULTS +18913 RESULTS +18914 RESULTS +18915 RESULTS +18916 RESULTS +18917 CONCLUSIONS +18918 BACKGROUND +18919 BACKGROUND +18920 BACKGROUND +18921 METHODS +18922 METHODS +18923 METHODS +18924 METHODS +18925 RESULTS +18926 RESULTS +18927 RESULTS +18928 RESULTS +18929 RESULTS +18930 CONCLUSIONS +18931 CONCLUSIONS +18932 BACKGROUND +18933 BACKGROUND +18934 METHODS +18935 METHODS +18936 METHODS +18937 RESULTS +18938 RESULTS +18939 RESULTS +18940 RESULTS +18941 CONCLUSIONS +18942 OBJECTIVE +18943 METHODS +18944 METHODS +18945 METHODS +18946 RESULTS +18947 RESULTS +18948 RESULTS +18949 RESULTS +18950 RESULTS +18951 RESULTS +18952 CONCLUSIONS +18953 OBJECTIVE +18954 METHODS +18955 METHODS +18956 METHODS +18957 METHODS +18958 RESULTS +18959 RESULTS +18960 RESULTS +18961 RESULTS +18962 RESULTS +18963 CONCLUSIONS +18964 OBJECTIVE +18965 OBJECTIVE +18966 METHODS +18967 METHODS +18968 METHODS +18969 METHODS +18970 METHODS +18971 METHODS +18972 METHODS +18973 RESULTS +18974 RESULTS +18975 RESULTS +18976 RESULTS +18977 RESULTS +18978 CONCLUSIONS +18979 OBJECTIVE +18980 METHODS +18981 RESULTS +18982 RESULTS +18983 CONCLUSIONS +18984 BACKGROUND +18985 BACKGROUND +18986 METHODS +18987 METHODS +18988 RESULTS +18989 RESULTS +18990 CONCLUSIONS +18991 OBJECTIVE +18992 OBJECTIVE +18993 RESULTS +18994 RESULTS +18995 RESULTS +18996 RESULTS +18997 RESULTS +18998 CONCLUSIONS +18999 CONCLUSIONS +19000 OBJECTIVE +19001 METHODS +19002 METHODS +19003 METHODS +19004 METHODS +19005 METHODS +19006 RESULTS +19007 RESULTS +19008 RESULTS +19009 RESULTS +19010 CONCLUSIONS +19011 BACKGROUND +19012 BACKGROUND +19013 BACKGROUND +19014 METHODS +19015 METHODS +19016 METHODS +19017 METHODS +19018 METHODS +19019 METHODS +19020 RESULTS +19021 RESULTS +19022 RESULTS +19023 RESULTS +19024 RESULTS +19025 CONCLUSIONS +19026 RESULTS +19027 RESULTS +19028 BACKGROUND +19029 OBJECTIVE +19030 METHODS +19031 METHODS +19032 METHODS +19033 METHODS +19034 METHODS +19035 RESULTS +19036 RESULTS +19037 RESULTS +19038 RESULTS +19039 RESULTS +19040 CONCLUSIONS +19041 BACKGROUND +19042 BACKGROUND +19043 OBJECTIVE +19044 METHODS +19045 METHODS +19046 METHODS +19047 METHODS +19048 METHODS +19049 RESULTS +19050 RESULTS +19051 RESULTS +19052 RESULTS +19053 RESULTS +19054 RESULTS +19055 RESULTS +19056 RESULTS +19057 RESULTS +19058 RESULTS +19059 CONCLUSIONS +19060 RESULTS +19061 CONCLUSIONS +19062 BACKGROUND +19063 OBJECTIVE +19064 METHODS +19065 METHODS +19066 RESULTS +19067 CONCLUSIONS +19068 RESULTS +19069 CONCLUSIONS +19070 CONCLUSIONS +19071 CONCLUSIONS +19072 OBJECTIVE +19073 METHODS +19074 METHODS +19075 RESULTS +19076 RESULTS +19077 RESULTS +19078 RESULTS +19079 RESULTS +19080 CONCLUSIONS +19081 RESULTS +19082 OBJECTIVE +19083 METHODS +19084 METHODS +19085 METHODS +19086 RESULTS +19087 RESULTS +19088 RESULTS +19089 RESULTS +19090 CONCLUSIONS +19091 BACKGROUND +19092 BACKGROUND +19093 OBJECTIVE +19094 METHODS +19095 METHODS +19096 METHODS +19097 RESULTS +19098 RESULTS +19099 RESULTS +19100 CONCLUSIONS +19101 CONCLUSIONS +19102 OBJECTIVE +19103 OBJECTIVE +19104 METHODS +19105 METHODS +19106 METHODS +19107 METHODS +19108 RESULTS +19109 RESULTS +19110 RESULTS +19111 RESULTS +19112 RESULTS +19113 RESULTS +19114 RESULTS +19115 RESULTS +19116 RESULTS +19117 CONCLUSIONS +19118 RESULTS +19119 CONCLUSIONS +19120 OBJECTIVE +19121 METHODS +19122 METHODS +19123 METHODS +19124 RESULTS +19125 RESULTS +19126 RESULTS +19127 CONCLUSIONS +19128 OBJECTIVE +19129 BACKGROUND +19130 BACKGROUND +19131 METHODS +19132 METHODS +19133 METHODS +19134 METHODS +19135 RESULTS +19136 RESULTS +19137 CONCLUSIONS +19138 CONCLUSIONS +19139 CONCLUSIONS +19140 CONCLUSIONS +19141 CONCLUSIONS +19142 BACKGROUND +19143 BACKGROUND +19144 OBJECTIVE +19145 METHODS +19146 OBJECTIVE +19147 METHODS +19148 RESULTS +19149 RESULTS +19150 RESULTS +19151 RESULTS +19152 RESULTS +19153 CONCLUSIONS +19154 BACKGROUND +19155 METHODS +19156 METHODS +19157 RESULTS +19158 RESULTS +19159 RESULTS +19160 CONCLUSIONS +19161 RESULTS +19162 BACKGROUND +19163 BACKGROUND +19164 CONCLUSIONS +19165 OBJECTIVE +19166 METHODS +19167 METHODS +19168 METHODS +19169 METHODS +19170 RESULTS +19171 RESULTS +19172 RESULTS +19173 RESULTS +19174 CONCLUSIONS +19175 CONCLUSIONS +19176 OBJECTIVE +19177 OBJECTIVE +19178 METHODS +19179 METHODS +19180 METHODS +19181 METHODS +19182 RESULTS +19183 RESULTS +19184 RESULTS +19185 METHODS +19186 RESULTS +19187 RESULTS +19188 RESULTS +19189 RESULTS +19190 CONCLUSIONS +19191 OBJECTIVE +19192 METHODS +19193 METHODS +19194 RESULTS +19195 RESULTS +19196 RESULTS +19197 RESULTS +19198 RESULTS +19199 CONCLUSIONS +19200 CONCLUSIONS +19201 CONCLUSIONS +19202 BACKGROUND +19203 BACKGROUND +19204 BACKGROUND +19205 BACKGROUND +19206 OBJECTIVE +19207 METHODS +19208 METHODS +19209 METHODS +19210 METHODS +19211 METHODS +19212 CONCLUSIONS +19213 BACKGROUND +19214 BACKGROUND +19215 OBJECTIVE +19216 METHODS +19217 METHODS +19218 METHODS +19219 METHODS +19220 METHODS +19221 METHODS +19222 RESULTS +19223 RESULTS +19224 RESULTS +19225 RESULTS +19226 RESULTS +19227 CONCLUSIONS +19228 CONCLUSIONS +19229 OBJECTIVE +19230 METHODS +19231 METHODS +19232 METHODS +19233 RESULTS +19234 RESULTS +19235 RESULTS +19236 RESULTS +19237 RESULTS +19238 RESULTS +19239 RESULTS +19240 RESULTS +19241 RESULTS +19242 RESULTS +19243 BACKGROUND +19244 CONCLUSIONS +19245 BACKGROUND +19246 OBJECTIVE +19247 METHODS +19248 METHODS +19249 METHODS +19250 METHODS +19251 METHODS +19252 METHODS +19253 CONCLUSIONS +19254 BACKGROUND +19255 OBJECTIVE +19256 METHODS +19257 RESULTS +19258 RESULTS +19259 RESULTS +19260 RESULTS +19261 RESULTS +19262 CONCLUSIONS +19263 OBJECTIVE +19264 METHODS +19265 RESULTS +19266 RESULTS +19267 RESULTS +19268 RESULTS +19269 RESULTS +19270 CONCLUSIONS +19271 BACKGROUND +19272 OBJECTIVE +19273 METHODS +19274 METHODS +19275 METHODS +19276 METHODS +19277 METHODS +19278 METHODS +19279 METHODS +19280 RESULTS +19281 RESULTS +19282 RESULTS +19283 CONCLUSIONS +19284 OBJECTIVE +19285 METHODS +19286 METHODS +19287 METHODS +19288 METHODS +19289 METHODS +19290 RESULTS +19291 RESULTS +19292 RESULTS +19293 CONCLUSIONS +19294 BACKGROUND +19295 BACKGROUND +19296 METHODS +19297 METHODS +19298 METHODS +19299 METHODS +19300 METHODS +19301 RESULTS +19302 RESULTS +19303 RESULTS +19304 RESULTS +19305 RESULTS +19306 RESULTS +19307 BACKGROUND +19308 BACKGROUND +19309 OBJECTIVE +19310 METHODS +19311 METHODS +19312 METHODS +19313 METHODS +19314 METHODS +19315 METHODS +19316 METHODS +19317 RESULTS +19318 RESULTS +19319 CONCLUSIONS +19320 OBJECTIVE +19321 METHODS +19322 METHODS +19323 METHODS +19324 METHODS +19325 RESULTS +19326 METHODS +19327 RESULTS +19328 RESULTS +19329 RESULTS +19330 RESULTS +19331 RESULTS +19332 RESULTS +19333 RESULTS +19334 CONCLUSIONS +19335 METHODS +19336 OBJECTIVE +19337 METHODS +19338 METHODS +19339 METHODS +19340 RESULTS +19341 RESULTS +19342 RESULTS +19343 RESULTS +19344 CONCLUSIONS +19345 OBJECTIVE +19346 OBJECTIVE +19347 METHODS +19348 METHODS +19349 RESULTS +19350 METHODS +19351 RESULTS +19352 CONCLUSIONS +19353 RESULTS +19354 RESULTS +19355 CONCLUSIONS +19356 BACKGROUND +19357 OBJECTIVE +19358 OBJECTIVE +19359 METHODS +19360 METHODS +19361 RESULTS +19362 RESULTS +19363 RESULTS +19364 CONCLUSIONS +19365 BACKGROUND +19366 BACKGROUND +19367 OBJECTIVE +19368 METHODS +19369 METHODS +19370 RESULTS +19371 RESULTS +19372 RESULTS +19373 RESULTS +19374 RESULTS +19375 RESULTS +19376 CONCLUSIONS +19377 CONCLUSIONS +19378 OBJECTIVE +19379 METHODS +19380 METHODS +19381 RESULTS +19382 RESULTS +19383 CONCLUSIONS +19384 BACKGROUND +19385 METHODS +19386 METHODS +19387 METHODS +19388 RESULTS +19389 RESULTS +19390 CONCLUSIONS +19391 BACKGROUND +19392 OBJECTIVE +19393 METHODS +19394 METHODS +19395 METHODS +19396 METHODS +19397 RESULTS +19398 RESULTS +19399 RESULTS +19400 RESULTS +19401 RESULTS +19402 RESULTS +19403 CONCLUSIONS +19404 BACKGROUND +19405 BACKGROUND +19406 OBJECTIVE +19407 CONCLUSIONS +19408 METHODS +19409 METHODS +19410 RESULTS +19411 METHODS +19412 OBJECTIVE +19413 METHODS +19414 METHODS +19415 METHODS +19416 METHODS +19417 RESULTS +19418 RESULTS +19419 RESULTS +19420 RESULTS +19421 RESULTS +19422 RESULTS +19423 RESULTS +19424 RESULTS +19425 CONCLUSIONS +19426 CONCLUSIONS +19427 BACKGROUND +19428 BACKGROUND +19429 METHODS +19430 METHODS +19431 METHODS +19432 RESULTS +19433 RESULTS +19434 RESULTS +19435 CONCLUSIONS +19436 CONCLUSIONS +19437 OBJECTIVE +19438 OBJECTIVE +19439 METHODS +19440 METHODS +19441 RESULTS +19442 RESULTS +19443 RESULTS +19444 CONCLUSIONS +19445 BACKGROUND +19446 BACKGROUND +19447 OBJECTIVE +19448 METHODS +19449 METHODS +19450 METHODS +19451 METHODS +19452 METHODS +19453 RESULTS +19454 RESULTS +19455 RESULTS +19456 RESULTS +19457 RESULTS +19458 BACKGROUND +19459 BACKGROUND +19460 BACKGROUND +19461 METHODS +19462 METHODS +19463 METHODS +19464 METHODS +19465 RESULTS +19466 CONCLUSIONS +19467 BACKGROUND +19468 BACKGROUND +19469 BACKGROUND +19470 METHODS +19471 METHODS +19472 METHODS +19473 METHODS +19474 RESULTS +19475 RESULTS +19476 RESULTS +19477 CONCLUSIONS +19478 CONCLUSIONS +19479 BACKGROUND +19480 BACKGROUND +19481 METHODS +19482 METHODS +19483 METHODS +19484 METHODS +19485 METHODS +19486 METHODS +19487 RESULTS +19488 RESULTS +19489 CONCLUSIONS +19490 OBJECTIVE +19491 METHODS +19492 METHODS +19493 METHODS +19494 METHODS +19495 METHODS +19496 RESULTS +19497 METHODS +19498 RESULTS +19499 RESULTS +19500 CONCLUSIONS +19501 BACKGROUND +19502 RESULTS +19503 RESULTS +19504 RESULTS +19505 CONCLUSIONS +19506 BACKGROUND +19507 OBJECTIVE +19508 METHODS +19509 METHODS +19510 METHODS +19511 METHODS +19512 METHODS +19513 RESULTS +19514 RESULTS +19515 RESULTS +19516 RESULTS +19517 CONCLUSIONS +19518 BACKGROUND +19519 BACKGROUND +19520 METHODS +19521 METHODS +19522 METHODS +19523 RESULTS +19524 RESULTS +19525 CONCLUSIONS +19526 CONCLUSIONS +19527 BACKGROUND +19528 BACKGROUND +19529 METHODS +19530 METHODS +19531 RESULTS +19532 RESULTS +19533 RESULTS +19534 RESULTS +19535 CONCLUSIONS +19536 OBJECTIVE +19537 BACKGROUND +19538 OBJECTIVE +19539 RESULTS +19540 RESULTS +19541 METHODS +19542 RESULTS +19543 RESULTS +19544 CONCLUSIONS +19545 CONCLUSIONS +19546 CONCLUSIONS +19547 CONCLUSIONS +19548 BACKGROUND +19549 CONCLUSIONS +19550 BACKGROUND +19551 OBJECTIVE +19552 METHODS +19553 METHODS +19554 METHODS +19555 METHODS +19556 METHODS +19557 RESULTS +19558 RESULTS +19559 RESULTS +19560 RESULTS +19561 CONCLUSIONS +19562 OBJECTIVE +19563 METHODS +19564 METHODS +19565 METHODS +19566 METHODS +19567 METHODS +19568 METHODS +19569 RESULTS +19570 RESULTS +19571 CONCLUSIONS +19572 CONCLUSIONS +19573 OBJECTIVE +19574 METHODS +19575 METHODS +19576 METHODS +19577 RESULTS +19578 RESULTS +19579 RESULTS +19580 RESULTS +19581 RESULTS +19582 RESULTS +19583 RESULTS +19584 CONCLUSIONS +19585 RESULTS +19586 CONCLUSIONS +19587 BACKGROUND +19588 OBJECTIVE +19589 METHODS +19590 RESULTS +19591 METHODS +19592 RESULTS +19593 RESULTS +19594 RESULTS +19595 CONCLUSIONS +19596 OBJECTIVE +19597 METHODS +19598 METHODS +19599 METHODS +19600 METHODS +19601 METHODS +19602 METHODS +19603 RESULTS +19604 RESULTS +19605 RESULTS +19606 RESULTS +19607 RESULTS +19608 RESULTS +19609 CONCLUSIONS +19610 OBJECTIVE +19611 METHODS +19612 METHODS +19613 METHODS +19614 METHODS +19615 RESULTS +19616 RESULTS +19617 RESULTS +19618 CONCLUSIONS +19619 RESULTS +19620 BACKGROUND +19621 BACKGROUND +19622 METHODS +19623 METHODS +19624 METHODS +19625 METHODS +19626 RESULTS +19627 RESULTS +19628 CONCLUSIONS +19629 RESULTS +19630 CONCLUSIONS +19631 CONCLUSIONS +19632 OBJECTIVE +19633 METHODS +19634 METHODS +19635 METHODS +19636 METHODS +19637 METHODS +19638 RESULTS +19639 RESULTS +19640 RESULTS +19641 RESULTS +19642 BACKGROUND +19643 CONCLUSIONS +19644 CONCLUSIONS +19645 CONCLUSIONS +19646 OBJECTIVE +19647 METHODS +19648 METHODS +19649 METHODS +19650 RESULTS +19651 RESULTS +19652 RESULTS +19653 CONCLUSIONS +19654 OBJECTIVE +19655 METHODS +19656 METHODS +19657 METHODS +19658 METHODS +19659 RESULTS +19660 RESULTS +19661 RESULTS +19662 RESULTS +19663 RESULTS +19664 RESULTS +19665 RESULTS +19666 CONCLUSIONS +19667 CONCLUSIONS +19668 OBJECTIVE +19669 METHODS +19670 METHODS +19671 RESULTS +19672 RESULTS +19673 RESULTS +19674 RESULTS +19675 RESULTS +19676 CONCLUSIONS +19677 BACKGROUND +19678 CONCLUSIONS +19679 OBJECTIVE +19680 METHODS +19681 RESULTS +19682 RESULTS +19683 RESULTS +19684 CONCLUSIONS +19685 BACKGROUND +19686 BACKGROUND +19687 METHODS +19688 METHODS +19689 METHODS +19690 RESULTS +19691 RESULTS +19692 CONCLUSIONS +19693 BACKGROUND +19694 BACKGROUND +19695 OBJECTIVE +19696 METHODS +19697 METHODS +19698 RESULTS +19699 RESULTS +19700 RESULTS +19701 RESULTS +19702 CONCLUSIONS +19703 OBJECTIVE +19704 METHODS +19705 METHODS +19706 METHODS +19707 RESULTS +19708 RESULTS +19709 RESULTS +19710 RESULTS +19711 RESULTS +19712 RESULTS +19713 RESULTS +19714 CONCLUSIONS +19715 CONCLUSIONS +19716 CONCLUSIONS +19717 OBJECTIVE +19718 OBJECTIVE +19719 BACKGROUND +19720 METHODS +19721 METHODS +19722 METHODS +19723 METHODS +19724 METHODS +19725 METHODS +19726 METHODS +19727 METHODS +19728 METHODS +19729 METHODS +19730 METHODS +19731 METHODS +19732 CONCLUSIONS +19733 BACKGROUND +19734 OBJECTIVE +19735 METHODS +19736 METHODS +19737 METHODS +19738 METHODS +19739 METHODS +19740 METHODS +19741 METHODS +19742 METHODS +19743 RESULTS +19744 RESULTS +19745 RESULTS +19746 RESULTS +19747 RESULTS +19748 RESULTS +19749 RESULTS +19750 CONCLUSIONS +19751 OBJECTIVE +19752 METHODS +19753 METHODS +19754 METHODS +19755 RESULTS +19756 METHODS +19757 METHODS +19758 RESULTS +19759 RESULTS +19760 RESULTS +19761 RESULTS +19762 CONCLUSIONS +19763 BACKGROUND +19764 BACKGROUND +19765 CONCLUSIONS +19766 CONCLUSIONS +19767 BACKGROUND +19768 METHODS +19769 METHODS +19770 METHODS +19771 METHODS +19772 RESULTS +19773 RESULTS +19774 RESULTS +19775 METHODS +19776 RESULTS +19777 RESULTS +19778 RESULTS +19779 RESULTS +19780 BACKGROUND +19781 CONCLUSIONS +19782 CONCLUSIONS +19783 BACKGROUND +19784 OBJECTIVE +19785 METHODS +19786 METHODS +19787 RESULTS +19788 RESULTS +19789 RESULTS +19790 CONCLUSIONS +19791 OBJECTIVE +19792 METHODS +19793 METHODS +19794 METHODS +19795 METHODS +19796 METHODS +19797 RESULTS +19798 RESULTS +19799 RESULTS +19800 RESULTS +19801 RESULTS +19802 CONCLUSIONS +19803 CONCLUSIONS +19804 BACKGROUND +19805 BACKGROUND +19806 OBJECTIVE +19807 METHODS +19808 METHODS +19809 METHODS +19810 RESULTS +19811 METHODS +19812 METHODS +19813 METHODS +19814 METHODS +19815 RESULTS +19816 CONCLUSIONS +19817 METHODS +19818 OBJECTIVE +19819 METHODS +19820 METHODS +19821 METHODS +19822 METHODS +19823 METHODS +19824 METHODS +19825 RESULTS +19826 RESULTS +19827 RESULTS +19828 CONCLUSIONS +19829 BACKGROUND +19830 METHODS +19831 METHODS +19832 RESULTS +19833 RESULTS +19834 RESULTS +19835 RESULTS +19836 CONCLUSIONS +19837 CONCLUSIONS +19838 OBJECTIVE +19839 METHODS +19840 METHODS +19841 METHODS +19842 METHODS +19843 METHODS +19844 METHODS +19845 RESULTS +19846 RESULTS +19847 RESULTS +19848 RESULTS +19849 CONCLUSIONS +19850 CONCLUSIONS +19851 BACKGROUND +19852 OBJECTIVE +19853 OBJECTIVE +19854 METHODS +19855 METHODS +19856 RESULTS +19857 RESULTS +19858 CONCLUSIONS +19859 OBJECTIVE +19860 METHODS +19861 METHODS +19862 RESULTS +19863 RESULTS +19864 RESULTS +19865 RESULTS +19866 RESULTS +19867 CONCLUSIONS +19868 OBJECTIVE +19869 METHODS +19870 METHODS +19871 CONCLUSIONS +19872 RESULTS +19873 CONCLUSIONS +19874 OBJECTIVE +19875 BACKGROUND +19876 BACKGROUND +19877 OBJECTIVE +19878 METHODS +19879 METHODS +19880 RESULTS +19881 RESULTS +19882 CONCLUSIONS +19883 RESULTS +19884 RESULTS +19885 CONCLUSIONS +19886 CONCLUSIONS +19887 OBJECTIVE +19888 OBJECTIVE +19889 METHODS +19890 RESULTS +19891 RESULTS +19892 CONCLUSIONS +19893 CONCLUSIONS +19894 CONCLUSIONS +19895 BACKGROUND +19896 BACKGROUND +19897 BACKGROUND +19898 OBJECTIVE +19899 METHODS +19900 METHODS +19901 METHODS +19902 METHODS +19903 RESULTS +19904 RESULTS +19905 RESULTS +19906 RESULTS +19907 CONCLUSIONS +19908 RESULTS +19909 RESULTS +19910 BACKGROUND +19911 BACKGROUND +19912 OBJECTIVE +19913 METHODS +19914 METHODS +19915 METHODS +19916 RESULTS +19917 RESULTS +19918 CONCLUSIONS +19919 CONCLUSIONS +19920 OBJECTIVE +19921 METHODS +19922 METHODS +19923 METHODS +19924 RESULTS +19925 METHODS +19926 METHODS +19927 METHODS +19928 RESULTS +19929 RESULTS +19930 RESULTS +19931 RESULTS +19932 CONCLUSIONS +19933 BACKGROUND +19934 CONCLUSIONS +19935 BACKGROUND +19936 METHODS +19937 METHODS +19938 METHODS +19939 METHODS +19940 METHODS +19941 RESULTS +19942 RESULTS +19943 RESULTS +19944 RESULTS +19945 CONCLUSIONS +19946 CONCLUSIONS +19947 OBJECTIVE +19948 METHODS +19949 METHODS +19950 METHODS +19951 METHODS +19952 RESULTS +19953 RESULTS +19954 CONCLUSIONS +19955 RESULTS +19956 OBJECTIVE +19957 METHODS +19958 METHODS +19959 METHODS +19960 METHODS +19961 METHODS +19962 METHODS +19963 RESULTS +19964 RESULTS +19965 CONCLUSIONS +19966 OBJECTIVE +19967 METHODS +19968 METHODS +19969 METHODS +19970 RESULTS +19971 RESULTS +19972 RESULTS +19973 CONCLUSIONS +19974 BACKGROUND +19975 BACKGROUND +19976 CONCLUSIONS +19977 OBJECTIVE +19978 BACKGROUND +19979 METHODS +19980 METHODS +19981 METHODS +19982 METHODS +19983 METHODS +19984 METHODS +19985 METHODS +19986 METHODS +19987 METHODS +19988 CONCLUSIONS +19989 CONCLUSIONS +19990 BACKGROUND +19991 OBJECTIVE +19992 RESULTS +19993 METHODS +19994 METHODS +19995 METHODS +19996 RESULTS +19997 RESULTS +19998 RESULTS +19999 RESULTS +20000 RESULTS +20001 CONCLUSIONS +20002 OBJECTIVE +20003 METHODS +20004 METHODS +20005 METHODS +20006 METHODS +20007 RESULTS +20008 RESULTS +20009 RESULTS +20010 RESULTS +20011 CONCLUSIONS +20012 OBJECTIVE +20013 CONCLUSIONS +20014 METHODS +20015 METHODS +20016 RESULTS +20017 RESULTS +20018 RESULTS +20019 RESULTS +20020 RESULTS +20021 RESULTS +20022 CONCLUSIONS +20023 CONCLUSIONS +20024 BACKGROUND +20025 RESULTS +20026 BACKGROUND +20027 BACKGROUND +20028 METHODS +20029 METHODS +20030 METHODS +20031 METHODS +20032 RESULTS +20033 RESULTS +20034 RESULTS +20035 RESULTS +20036 CONCLUSIONS +20037 CONCLUSIONS +20038 OBJECTIVE +20039 METHODS +20040 METHODS +20041 METHODS +20042 METHODS +20043 METHODS +20044 METHODS +20045 RESULTS +20046 RESULTS +20047 RESULTS +20048 RESULTS +20049 RESULTS +20050 RESULTS +20051 BACKGROUND +20052 BACKGROUND +20053 CONCLUSIONS +20054 BACKGROUND +20055 METHODS +20056 RESULTS +20057 RESULTS +20058 RESULTS +20059 CONCLUSIONS +20060 CONCLUSIONS +20061 BACKGROUND +20062 CONCLUSIONS +20063 METHODS +20064 METHODS +20065 METHODS +20066 RESULTS +20067 RESULTS +20068 RESULTS +20069 RESULTS +20070 RESULTS +20071 CONCLUSIONS +20072 BACKGROUND +20073 BACKGROUND +20074 OBJECTIVE +20075 METHODS +20076 METHODS +20077 METHODS +20078 METHODS +20079 RESULTS +20080 RESULTS +20081 RESULTS +20082 RESULTS +20083 RESULTS +20084 CONCLUSIONS +20085 OBJECTIVE +20086 METHODS +20087 METHODS +20088 METHODS +20089 RESULTS +20090 RESULTS +20091 RESULTS +20092 CONCLUSIONS +20093 BACKGROUND +20094 BACKGROUND +20095 BACKGROUND +20096 METHODS +20097 METHODS +20098 METHODS +20099 RESULTS +20100 RESULTS +20101 RESULTS +20102 RESULTS +20103 RESULTS +20104 RESULTS +20105 BACKGROUND +20106 OBJECTIVE +20107 METHODS +20108 METHODS +20109 METHODS +20110 METHODS +20111 RESULTS +20112 RESULTS +20113 RESULTS +20114 BACKGROUND +20115 CONCLUSIONS +20116 BACKGROUND +20117 OBJECTIVE +20118 METHODS +20119 METHODS +20120 METHODS +20121 METHODS +20122 METHODS +20123 RESULTS +20124 RESULTS +20125 RESULTS +20126 RESULTS +20127 CONCLUSIONS +20128 CONCLUSIONS +20129 RESULTS +20130 CONCLUSIONS +20131 BACKGROUND +20132 METHODS +20133 METHODS +20134 METHODS +20135 METHODS +20136 RESULTS +20137 RESULTS +20138 RESULTS +20139 RESULTS +20140 RESULTS +20141 CONCLUSIONS +20142 CONCLUSIONS +20143 BACKGROUND +20144 OBJECTIVE +20145 METHODS +20146 METHODS +20147 METHODS +20148 METHODS +20149 METHODS +20150 METHODS +20151 METHODS +20152 RESULTS +20153 RESULTS +20154 RESULTS +20155 RESULTS +20156 CONCLUSIONS +20157 BACKGROUND +20158 METHODS +20159 METHODS +20160 METHODS +20161 METHODS +20162 METHODS +20163 METHODS +20164 METHODS +20165 RESULTS +20166 RESULTS +20167 RESULTS +20168 CONCLUSIONS +20169 BACKGROUND +20170 BACKGROUND +20171 OBJECTIVE +20172 METHODS +20173 METHODS +20174 CONCLUSIONS +20175 RESULTS +20176 CONCLUSIONS +20177 BACKGROUND +20178 BACKGROUND +20179 BACKGROUND +20180 METHODS +20181 METHODS +20182 RESULTS +20183 RESULTS +20184 RESULTS +20185 RESULTS +20186 RESULTS +20187 RESULTS +20188 CONCLUSIONS +20189 RESULTS +20190 BACKGROUND +20191 METHODS +20192 METHODS +20193 METHODS +20194 METHODS +20195 METHODS +20196 OBJECTIVE +20197 RESULTS +20198 RESULTS +20199 CONCLUSIONS +20200 BACKGROUND +20201 OBJECTIVE +20202 METHODS +20203 METHODS +20204 METHODS +20205 METHODS +20206 RESULTS +20207 RESULTS +20208 RESULTS +20209 RESULTS +20210 RESULTS +20211 CONCLUSIONS +20212 CONCLUSIONS +20213 BACKGROUND +20214 BACKGROUND +20215 BACKGROUND +20216 BACKGROUND +20217 BACKGROUND +20218 METHODS +20219 METHODS +20220 METHODS +20221 RESULTS +20222 RESULTS +20223 RESULTS +20224 CONCLUSIONS +20225 OBJECTIVE +20226 BACKGROUND +20227 METHODS +20228 METHODS +20229 RESULTS +20230 RESULTS +20231 RESULTS +20232 RESULTS +20233 CONCLUSIONS +20234 CONCLUSIONS +20235 OBJECTIVE +20236 BACKGROUND +20237 METHODS +20238 METHODS +20239 RESULTS +20240 RESULTS +20241 CONCLUSIONS +20242 RESULTS +20243 CONCLUSIONS +20244 CONCLUSIONS +20245 CONCLUSIONS +20246 BACKGROUND +20247 BACKGROUND +20248 METHODS +20249 METHODS +20250 METHODS +20251 METHODS +20252 RESULTS +20253 RESULTS +20254 RESULTS +20255 RESULTS +20256 CONCLUSIONS +20257 BACKGROUND +20258 BACKGROUND +20259 METHODS +20260 RESULTS +20261 METHODS +20262 METHODS +20263 CONCLUSIONS +20264 CONCLUSIONS +20265 CONCLUSIONS +20266 CONCLUSIONS +20267 CONCLUSIONS +20268 OBJECTIVE +20269 METHODS +20270 METHODS +20271 METHODS +20272 METHODS +20273 METHODS +20274 RESULTS +20275 RESULTS +20276 RESULTS +20277 CONCLUSIONS +20278 OBJECTIVE +20279 METHODS +20280 RESULTS +20281 RESULTS +20282 RESULTS +20283 RESULTS +20284 CONCLUSIONS +20285 CONCLUSIONS +20286 OBJECTIVE +20287 CONCLUSIONS +20288 BACKGROUND +20289 BACKGROUND +20290 RESULTS +20291 RESULTS +20292 RESULTS +20293 RESULTS +20294 RESULTS +20295 CONCLUSIONS +20296 OBJECTIVE +20297 BACKGROUND +20298 BACKGROUND +20299 METHODS +20300 METHODS +20301 METHODS +20302 METHODS +20303 RESULTS +20304 RESULTS +20305 RESULTS +20306 RESULTS +20307 RESULTS +20308 CONCLUSIONS +20309 CONCLUSIONS +20310 OBJECTIVE +20311 METHODS +20312 METHODS +20313 METHODS +20314 METHODS +20315 METHODS +20316 METHODS +20317 METHODS +20318 RESULTS +20319 RESULTS +20320 RESULTS +20321 CONCLUSIONS +20322 CONCLUSIONS +20323 CONCLUSIONS +20324 OBJECTIVE +20325 METHODS +20326 METHODS +20327 METHODS +20328 METHODS +20329 METHODS +20330 RESULTS +20331 RESULTS +20332 RESULTS +20333 METHODS +20334 CONCLUSIONS +20335 BACKGROUND +20336 OBJECTIVE +20337 METHODS +20338 METHODS +20339 METHODS +20340 METHODS +20341 METHODS +20342 RESULTS +20343 RESULTS +20344 CONCLUSIONS +20345 CONCLUSIONS +20346 METHODS +20347 BACKGROUND +20348 METHODS +20349 METHODS +20350 METHODS +20351 METHODS +20352 METHODS +20353 METHODS +20354 RESULTS +20355 RESULTS +20356 RESULTS +20357 CONCLUSIONS +20358 CONCLUSIONS +20359 BACKGROUND +20360 METHODS +20361 METHODS +20362 METHODS +20363 METHODS +20364 METHODS +20365 RESULTS +20366 RESULTS +20367 CONCLUSIONS +20368 OBJECTIVE +20369 BACKGROUND +20370 METHODS +20371 METHODS +20372 METHODS +20373 METHODS +20374 RESULTS +20375 RESULTS +20376 RESULTS +20377 RESULTS +20378 CONCLUSIONS +20379 CONCLUSIONS +20380 OBJECTIVE +20381 METHODS +20382 METHODS +20383 METHODS +20384 METHODS +20385 METHODS +20386 RESULTS +20387 RESULTS +20388 RESULTS +20389 CONCLUSIONS +20390 OBJECTIVE +20391 METHODS +20392 METHODS +20393 METHODS +20394 METHODS +20395 METHODS +20396 METHODS +20397 METHODS +20398 METHODS +20399 RESULTS +20400 RESULTS +20401 CONCLUSIONS +20402 BACKGROUND +20403 OBJECTIVE +20404 BACKGROUND +20405 METHODS +20406 METHODS +20407 RESULTS +20408 RESULTS +20409 RESULTS +20410 RESULTS +20411 RESULTS +20412 CONCLUSIONS +20413 BACKGROUND +20414 BACKGROUND +20415 OBJECTIVE +20416 METHODS +20417 METHODS +20418 METHODS +20419 METHODS +20420 RESULTS +20421 RESULTS +20422 CONCLUSIONS +20423 CONCLUSIONS +20424 OBJECTIVE +20425 METHODS +20426 METHODS +20427 METHODS +20428 METHODS +20429 METHODS +20430 METHODS +20431 RESULTS +20432 RESULTS +20433 RESULTS +20434 RESULTS +20435 RESULTS +20436 CONCLUSIONS +20437 BACKGROUND +20438 CONCLUSIONS +20439 OBJECTIVE +20440 RESULTS +20441 RESULTS +20442 RESULTS +20443 RESULTS +20444 CONCLUSIONS +20445 CONCLUSIONS +20446 BACKGROUND +20447 BACKGROUND +20448 METHODS +20449 METHODS +20450 RESULTS +20451 RESULTS +20452 RESULTS +20453 CONCLUSIONS +20454 CONCLUSIONS +20455 OBJECTIVE +20456 METHODS +20457 METHODS +20458 METHODS +20459 RESULTS +20460 RESULTS +20461 CONCLUSIONS +20462 CONCLUSIONS +20463 CONCLUSIONS +20464 CONCLUSIONS +20465 BACKGROUND +20466 BACKGROUND +20467 OBJECTIVE +20468 METHODS +20469 RESULTS +20470 RESULTS +20471 RESULTS +20472 CONCLUSIONS +20473 RESULTS +20474 BACKGROUND +20475 BACKGROUND +20476 METHODS +20477 METHODS +20478 METHODS +20479 RESULTS +20480 RESULTS +20481 RESULTS +20482 RESULTS +20483 RESULTS +20484 RESULTS +20485 RESULTS +20486 RESULTS +20487 CONCLUSIONS +20488 CONCLUSIONS +20489 RESULTS +20490 BACKGROUND +20491 OBJECTIVE +20492 METHODS +20493 METHODS +20494 METHODS +20495 METHODS +20496 METHODS +20497 RESULTS +20498 RESULTS +20499 RESULTS +20500 RESULTS +20501 RESULTS +20502 CONCLUSIONS +20503 BACKGROUND +20504 OBJECTIVE +20505 CONCLUSIONS +20506 OBJECTIVE +20507 METHODS +20508 METHODS +20509 METHODS +20510 RESULTS +20511 RESULTS +20512 RESULTS +20513 CONCLUSIONS +20514 CONCLUSIONS +20515 BACKGROUND +20516 BACKGROUND +20517 METHODS +20518 METHODS +20519 METHODS +20520 METHODS +20521 RESULTS +20522 RESULTS +20523 RESULTS +20524 RESULTS +20525 RESULTS +20526 CONCLUSIONS +20527 CONCLUSIONS +20528 BACKGROUND +20529 OBJECTIVE +20530 METHODS +20531 METHODS +20532 METHODS +20533 RESULTS +20534 RESULTS +20535 CONCLUSIONS +20536 CONCLUSIONS +20537 BACKGROUND +20538 OBJECTIVE +20539 METHODS +20540 METHODS +20541 METHODS +20542 RESULTS +20543 RESULTS +20544 RESULTS +20545 CONCLUSIONS +20546 CONCLUSIONS +20547 BACKGROUND +20548 BACKGROUND +20549 METHODS +20550 METHODS +20551 CONCLUSIONS +20552 RESULTS +20553 RESULTS +20554 RESULTS +20555 CONCLUSIONS +20556 CONCLUSIONS +20557 BACKGROUND +20558 OBJECTIVE +20559 METHODS +20560 METHODS +20561 RESULTS +20562 RESULTS +20563 CONCLUSIONS +20564 OBJECTIVE +20565 METHODS +20566 METHODS +20567 METHODS +20568 METHODS +20569 METHODS +20570 METHODS +20571 RESULTS +20572 RESULTS +20573 RESULTS +20574 RESULTS +20575 RESULTS +20576 RESULTS +20577 RESULTS +20578 CONCLUSIONS +20579 BACKGROUND +20580 OBJECTIVE +20581 METHODS +20582 METHODS +20583 METHODS +20584 RESULTS +20585 RESULTS +20586 RESULTS +20587 CONCLUSIONS +20588 CONCLUSIONS +20589 OBJECTIVE +20590 METHODS +20591 METHODS +20592 METHODS +20593 METHODS +20594 METHODS +20595 RESULTS +20596 RESULTS +20597 RESULTS +20598 RESULTS +20599 RESULTS +20600 RESULTS +20601 RESULTS +20602 BACKGROUND +20603 CONCLUSIONS +20604 OBJECTIVE +20605 METHODS +20606 METHODS +20607 METHODS +20608 METHODS +20609 METHODS +20610 METHODS +20611 METHODS +20612 METHODS +20613 METHODS +20614 RESULTS +20615 RESULTS +20616 RESULTS +20617 RESULTS +20618 RESULTS +20619 RESULTS +20620 RESULTS +20621 CONCLUSIONS +20622 BACKGROUND +20623 BACKGROUND +20624 OBJECTIVE +20625 METHODS +20626 RESULTS +20627 RESULTS +20628 RESULTS +20629 CONCLUSIONS +20630 OBJECTIVE +20631 METHODS +20632 METHODS +20633 RESULTS +20634 RESULTS +20635 RESULTS +20636 RESULTS +20637 RESULTS +20638 CONCLUSIONS +20639 CONCLUSIONS +20640 BACKGROUND +20641 OBJECTIVE +20642 METHODS +20643 METHODS +20644 METHODS +20645 METHODS +20646 METHODS +20647 RESULTS +20648 RESULTS +20649 RESULTS +20650 RESULTS +20651 RESULTS +20652 RESULTS +20653 CONCLUSIONS +20654 CONCLUSIONS +20655 BACKGROUND +20656 BACKGROUND +20657 METHODS +20658 METHODS +20659 BACKGROUND +20660 METHODS +20661 METHODS +20662 METHODS +20663 METHODS +20664 RESULTS +20665 RESULTS +20666 RESULTS +20667 RESULTS +20668 CONCLUSIONS +20669 BACKGROUND +20670 METHODS +20671 METHODS +20672 METHODS +20673 METHODS +20674 RESULTS +20675 RESULTS +20676 RESULTS +20677 RESULTS +20678 RESULTS +20679 RESULTS +20680 BACKGROUND +20681 CONCLUSIONS +20682 OBJECTIVE +20683 METHODS +20684 METHODS +20685 RESULTS +20686 RESULTS +20687 RESULTS +20688 RESULTS +20689 RESULTS +20690 RESULTS +20691 CONCLUSIONS +20692 CONCLUSIONS +20693 RESULTS +20694 BACKGROUND +20695 METHODS +20696 METHODS +20697 METHODS +20698 METHODS +20699 METHODS +20700 METHODS +20701 METHODS +20702 METHODS +20703 RESULTS +20704 RESULTS +20705 RESULTS +20706 CONCLUSIONS +20707 BACKGROUND +20708 BACKGROUND +20709 OBJECTIVE +20710 METHODS +20711 METHODS +20712 METHODS +20713 METHODS +20714 RESULTS +20715 RESULTS +20716 CONCLUSIONS +20717 CONCLUSIONS +20718 OBJECTIVE +20719 METHODS +20720 METHODS +20721 METHODS +20722 METHODS +20723 RESULTS +20724 RESULTS +20725 RESULTS +20726 CONCLUSIONS +20727 BACKGROUND +20728 CONCLUSIONS +20729 BACKGROUND +20730 BACKGROUND +20731 RESULTS +20732 METHODS +20733 METHODS +20734 RESULTS +20735 RESULTS +20736 RESULTS +20737 CONCLUSIONS +20738 BACKGROUND +20739 BACKGROUND +20740 OBJECTIVE +20741 METHODS +20742 RESULTS +20743 METHODS +20744 METHODS +20745 RESULTS +20746 RESULTS +20747 RESULTS +20748 RESULTS +20749 CONCLUSIONS +20750 CONCLUSIONS +20751 OBJECTIVE +20752 METHODS +20753 METHODS +20754 RESULTS +20755 RESULTS +20756 RESULTS +20757 RESULTS +20758 RESULTS +20759 RESULTS +20760 CONCLUSIONS +20761 CONCLUSIONS +20762 RESULTS +20763 BACKGROUND +20764 BACKGROUND +20765 OBJECTIVE +20766 METHODS +20767 METHODS +20768 METHODS +20769 METHODS +20770 RESULTS +20771 RESULTS +20772 RESULTS +20773 CONCLUSIONS +20774 BACKGROUND +20775 OBJECTIVE +20776 METHODS +20777 METHODS +20778 RESULTS +20779 RESULTS +20780 RESULTS +20781 CONCLUSIONS +20782 BACKGROUND +20783 CONCLUSIONS +20784 OBJECTIVE +20785 METHODS +20786 METHODS +20787 METHODS +20788 RESULTS +20789 RESULTS +20790 RESULTS +20791 RESULTS +20792 RESULTS +20793 CONCLUSIONS +20794 OBJECTIVE +20795 METHODS +20796 METHODS +20797 METHODS +20798 RESULTS +20799 RESULTS +20800 RESULTS +20801 RESULTS +20802 RESULTS +20803 RESULTS +20804 CONCLUSIONS +20805 CONCLUSIONS +20806 BACKGROUND +20807 METHODS +20808 METHODS +20809 METHODS +20810 RESULTS +20811 RESULTS +20812 RESULTS +20813 CONCLUSIONS +20814 CONCLUSIONS +20815 OBJECTIVE +20816 METHODS +20817 METHODS +20818 METHODS +20819 METHODS +20820 METHODS +20821 METHODS +20822 METHODS +20823 RESULTS +20824 RESULTS +20825 RESULTS +20826 RESULTS +20827 CONCLUSIONS +20828 OBJECTIVE +20829 METHODS +20830 METHODS +20831 METHODS +20832 METHODS +20833 METHODS +20834 RESULTS +20835 RESULTS +20836 CONCLUSIONS +20837 RESULTS +20838 CONCLUSIONS +20839 OBJECTIVE +20840 METHODS +20841 METHODS +20842 METHODS +20843 RESULTS +20844 RESULTS +20845 RESULTS +20846 RESULTS +20847 RESULTS +20848 CONCLUSIONS +20849 METHODS +20850 OBJECTIVE +20851 METHODS +20852 METHODS +20853 METHODS +20854 METHODS +20855 METHODS +20856 RESULTS +20857 RESULTS +20858 RESULTS +20859 RESULTS +20860 RESULTS +20861 RESULTS +20862 CONCLUSIONS +20863 BACKGROUND +20864 BACKGROUND +20865 OBJECTIVE +20866 METHODS +20867 METHODS +20868 METHODS +20869 RESULTS +20870 RESULTS +20871 RESULTS +20872 CONCLUSIONS +20873 CONCLUSIONS +20874 BACKGROUND +20875 BACKGROUND +20876 OBJECTIVE +20877 METHODS +20878 METHODS +20879 METHODS +20880 METHODS +20881 METHODS +20882 RESULTS +20883 RESULTS +20884 RESULTS +20885 RESULTS +20886 BACKGROUND +20887 CONCLUSIONS +20888 OBJECTIVE +20889 METHODS +20890 METHODS +20891 METHODS +20892 RESULTS +20893 RESULTS +20894 CONCLUSIONS +20895 CONCLUSIONS +20896 OBJECTIVE +20897 METHODS +20898 METHODS +20899 RESULTS +20900 RESULTS +20901 METHODS +20902 RESULTS +20903 RESULTS +20904 RESULTS +20905 RESULTS +20906 CONCLUSIONS +20907 CONCLUSIONS +20908 BACKGROUND +20909 BACKGROUND +20910 BACKGROUND +20911 BACKGROUND +20912 METHODS +20913 METHODS +20914 METHODS +20915 METHODS +20916 METHODS +20917 METHODS +20918 METHODS +20919 METHODS +20920 RESULTS +20921 RESULTS +20922 CONCLUSIONS +20923 CONCLUSIONS +20924 BACKGROUND +20925 BACKGROUND +20926 METHODS +20927 METHODS +20928 METHODS +20929 RESULTS +20930 RESULTS +20931 RESULTS +20932 RESULTS +20933 RESULTS +20934 RESULTS +20935 RESULTS +20936 CONCLUSIONS +20937 CONCLUSIONS +20938 BACKGROUND +20939 METHODS +20940 METHODS +20941 METHODS +20942 METHODS +20943 METHODS +20944 METHODS +20945 METHODS +20946 RESULTS +20947 RESULTS +20948 RESULTS +20949 RESULTS +20950 CONCLUSIONS +20951 CONCLUSIONS +20952 BACKGROUND +20953 METHODS +20954 METHODS +20955 METHODS +20956 METHODS +20957 RESULTS +20958 RESULTS +20959 RESULTS +20960 RESULTS +20961 RESULTS +20962 CONCLUSIONS +20963 BACKGROUND +20964 BACKGROUND +20965 METHODS +20966 METHODS +20967 METHODS +20968 METHODS +20969 RESULTS +20970 RESULTS +20971 CONCLUSIONS +20972 BACKGROUND +20973 BACKGROUND +20974 OBJECTIVE +20975 METHODS +20976 METHODS +20977 METHODS +20978 METHODS +20979 METHODS +20980 RESULTS +20981 RESULTS +20982 CONCLUSIONS +20983 CONCLUSIONS +20984 BACKGROUND +20985 OBJECTIVE +20986 METHODS +20987 METHODS +20988 RESULTS +20989 RESULTS +20990 RESULTS +20991 RESULTS +20992 RESULTS +20993 CONCLUSIONS +20994 BACKGROUND +20995 BACKGROUND +20996 BACKGROUND +20997 METHODS +20998 METHODS +20999 RESULTS +21000 RESULTS +21001 RESULTS +21002 RESULTS +21003 RESULTS +21004 BACKGROUND +21005 BACKGROUND +21006 CONCLUSIONS +21007 BACKGROUND +21008 OBJECTIVE +21009 METHODS +21010 RESULTS +21011 RESULTS +21012 RESULTS +21013 RESULTS +21014 CONCLUSIONS +21015 CONCLUSIONS +21016 BACKGROUND +21017 BACKGROUND +21018 METHODS +21019 OBJECTIVE +21020 METHODS +21021 METHODS +21022 METHODS +21023 METHODS +21024 METHODS +21025 RESULTS +21026 RESULTS +21027 CONCLUSIONS +21028 OBJECTIVE +21029 METHODS +21030 METHODS +21031 METHODS +21032 METHODS +21033 METHODS +21034 METHODS +21035 METHODS +21036 METHODS +21037 METHODS +21038 RESULTS +21039 RESULTS +21040 RESULTS +21041 RESULTS +21042 RESULTS +21043 RESULTS +21044 RESULTS +21045 CONCLUSIONS +21046 CONCLUSIONS +21047 BACKGROUND +21048 CONCLUSIONS +21049 BACKGROUND +21050 BACKGROUND +21051 BACKGROUND +21052 METHODS +21053 METHODS +21054 RESULTS +21055 RESULTS +21056 RESULTS +21057 CONCLUSIONS +21058 OBJECTIVE +21059 METHODS +21060 METHODS +21061 METHODS +21062 RESULTS +21063 RESULTS +21064 RESULTS +21065 RESULTS +21066 RESULTS +21067 RESULTS +21068 RESULTS +21069 CONCLUSIONS +21070 CONCLUSIONS +21071 OBJECTIVE +21072 METHODS +21073 METHODS +21074 RESULTS +21075 METHODS +21076 CONCLUSIONS +21077 BACKGROUND +21078 OBJECTIVE +21079 METHODS +21080 METHODS +21081 RESULTS +21082 CONCLUSIONS +21083 CONCLUSIONS +21084 BACKGROUND +21085 RESULTS +21086 METHODS +21087 METHODS +21088 RESULTS +21089 RESULTS +21090 RESULTS +21091 RESULTS +21092 RESULTS +21093 CONCLUSIONS +21094 OBJECTIVE +21095 METHODS +21096 METHODS +21097 METHODS +21098 METHODS +21099 METHODS +21100 METHODS +21101 METHODS +21102 METHODS +21103 RESULTS +21104 RESULTS +21105 RESULTS +21106 CONCLUSIONS +21107 OBJECTIVE +21108 METHODS +21109 METHODS +21110 METHODS +21111 RESULTS +21112 RESULTS +21113 RESULTS +21114 CONCLUSIONS +21115 CONCLUSIONS +21116 CONCLUSIONS +21117 METHODS +21118 METHODS +21119 METHODS +21120 METHODS +21121 METHODS +21122 METHODS +21123 RESULTS +21124 RESULTS +21125 RESULTS +21126 RESULTS +21127 CONCLUSIONS +21128 BACKGROUND +21129 BACKGROUND +21130 BACKGROUND +21131 OBJECTIVE +21132 METHODS +21133 METHODS +21134 RESULTS +21135 RESULTS +21136 RESULTS +21137 CONCLUSIONS +21138 BACKGROUND +21139 OBJECTIVE +21140 METHODS +21141 METHODS +21142 RESULTS +21143 METHODS +21144 RESULTS +21145 METHODS +21146 RESULTS +21147 RESULTS +21148 RESULTS +21149 CONCLUSIONS +21150 BACKGROUND +21151 BACKGROUND +21152 BACKGROUND +21153 BACKGROUND +21154 BACKGROUND +21155 METHODS +21156 METHODS +21157 METHODS +21158 RESULTS +21159 RESULTS +21160 RESULTS +21161 CONCLUSIONS +21162 CONCLUSIONS +21163 OBJECTIVE +21164 METHODS +21165 METHODS +21166 METHODS +21167 RESULTS +21168 RESULTS +21169 RESULTS +21170 RESULTS +21171 CONCLUSIONS +21172 OBJECTIVE +21173 METHODS +21174 METHODS +21175 METHODS +21176 METHODS +21177 RESULTS +21178 RESULTS +21179 RESULTS +21180 RESULTS +21181 RESULTS +21182 CONCLUSIONS +21183 CONCLUSIONS +21184 OBJECTIVE +21185 METHODS +21186 METHODS +21187 METHODS +21188 METHODS +21189 METHODS +21190 METHODS +21191 RESULTS +21192 RESULTS +21193 RESULTS +21194 RESULTS +21195 RESULTS +21196 RESULTS +21197 RESULTS +21198 CONCLUSIONS +21199 CONCLUSIONS +21200 CONCLUSIONS +21201 OBJECTIVE +21202 METHODS +21203 METHODS +21204 RESULTS +21205 RESULTS +21206 RESULTS +21207 RESULTS +21208 CONCLUSIONS +21209 CONCLUSIONS +21210 BACKGROUND +21211 METHODS +21212 METHODS +21213 METHODS +21214 METHODS +21215 METHODS +21216 RESULTS +21217 RESULTS +21218 RESULTS +21219 RESULTS +21220 RESULTS +21221 RESULTS +21222 CONCLUSIONS +21223 BACKGROUND +21224 OBJECTIVE +21225 METHODS +21226 METHODS +21227 METHODS +21228 METHODS +21229 RESULTS +21230 RESULTS +21231 CONCLUSIONS +21232 CONCLUSIONS +21233 BACKGROUND +21234 BACKGROUND +21235 OBJECTIVE +21236 METHODS +21237 METHODS +21238 METHODS +21239 METHODS +21240 METHODS +21241 RESULTS +21242 RESULTS +21243 RESULTS +21244 RESULTS +21245 RESULTS +21246 CONCLUSIONS +21247 OBJECTIVE +21248 METHODS +21249 METHODS +21250 METHODS +21251 RESULTS +21252 RESULTS +21253 RESULTS +21254 RESULTS +21255 RESULTS +21256 CONCLUSIONS +21257 CONCLUSIONS +21258 BACKGROUND +21259 BACKGROUND +21260 BACKGROUND +21261 OBJECTIVE +21262 RESULTS +21263 METHODS +21264 RESULTS +21265 RESULTS +21266 RESULTS +21267 CONCLUSIONS +21268 RESULTS +21269 BACKGROUND +21270 METHODS +21271 METHODS +21272 METHODS +21273 RESULTS +21274 RESULTS +21275 RESULTS +21276 RESULTS +21277 RESULTS +21278 CONCLUSIONS +21279 CONCLUSIONS +21280 OBJECTIVE +21281 METHODS +21282 METHODS +21283 METHODS +21284 METHODS +21285 RESULTS +21286 RESULTS +21287 RESULTS +21288 RESULTS +21289 CONCLUSIONS +21290 CONCLUSIONS +21291 BACKGROUND +21292 BACKGROUND +21293 BACKGROUND +21294 BACKGROUND +21295 BACKGROUND +21296 CONCLUSIONS +21297 METHODS +21298 METHODS +21299 CONCLUSIONS +21300 CONCLUSIONS +21301 BACKGROUND +21302 OBJECTIVE +21303 METHODS +21304 METHODS +21305 METHODS +21306 METHODS +21307 METHODS +21308 METHODS +21309 RESULTS +21310 RESULTS +21311 CONCLUSIONS +21312 OBJECTIVE +21313 METHODS +21314 METHODS +21315 RESULTS +21316 RESULTS +21317 CONCLUSIONS +21318 BACKGROUND +21319 OBJECTIVE +21320 METHODS +21321 METHODS +21322 METHODS +21323 METHODS +21324 METHODS +21325 METHODS +21326 RESULTS +21327 RESULTS +21328 RESULTS +21329 CONCLUSIONS +21330 CONCLUSIONS +21331 BACKGROUND +21332 OBJECTIVE +21333 METHODS +21334 METHODS +21335 METHODS +21336 RESULTS +21337 RESULTS +21338 CONCLUSIONS +21339 RESULTS +21340 RESULTS +21341 CONCLUSIONS +21342 BACKGROUND +21343 BACKGROUND +21344 BACKGROUND +21345 METHODS +21346 METHODS +21347 METHODS +21348 METHODS +21349 METHODS +21350 METHODS +21351 RESULTS +21352 RESULTS +21353 RESULTS +21354 RESULTS +21355 RESULTS +21356 CONCLUSIONS +21357 CONCLUSIONS +21358 BACKGROUND +21359 OBJECTIVE +21360 METHODS +21361 METHODS +21362 METHODS +21363 RESULTS +21364 RESULTS +21365 RESULTS +21366 RESULTS +21367 CONCLUSIONS +21368 OBJECTIVE +21369 METHODS +21370 METHODS +21371 METHODS +21372 METHODS +21373 METHODS +21374 METHODS +21375 METHODS +21376 METHODS +21377 METHODS +21378 RESULTS +21379 RESULTS +21380 RESULTS +21381 RESULTS +21382 RESULTS +21383 RESULTS +21384 CONCLUSIONS +21385 RESULTS +21386 BACKGROUND +21387 OBJECTIVE +21388 METHODS +21389 METHODS +21390 METHODS +21391 RESULTS +21392 BACKGROUND +21393 RESULTS +21394 CONCLUSIONS +21395 CONCLUSIONS +21396 CONCLUSIONS +21397 OBJECTIVE +21398 BACKGROUND +21399 METHODS +21400 RESULTS +21401 RESULTS +21402 RESULTS +21403 RESULTS +21404 RESULTS +21405 RESULTS +21406 RESULTS +21407 RESULTS +21408 RESULTS +21409 RESULTS +21410 CONCLUSIONS +21411 RESULTS +21412 CONCLUSIONS +21413 BACKGROUND +21414 BACKGROUND +21415 METHODS +21416 METHODS +21417 METHODS +21418 METHODS +21419 METHODS +21420 RESULTS +21421 RESULTS +21422 RESULTS +21423 RESULTS +21424 RESULTS +21425 CONCLUSIONS +21426 CONCLUSIONS +21427 OBJECTIVE +21428 METHODS +21429 METHODS +21430 METHODS +21431 METHODS +21432 RESULTS +21433 RESULTS +21434 CONCLUSIONS +21435 CONCLUSIONS +21436 BACKGROUND +21437 BACKGROUND +21438 METHODS +21439 METHODS +21440 METHODS +21441 RESULTS +21442 RESULTS +21443 RESULTS +21444 RESULTS +21445 RESULTS +21446 CONCLUSIONS +21447 CONCLUSIONS +21448 OBJECTIVE +21449 METHODS +21450 METHODS +21451 METHODS +21452 METHODS +21453 RESULTS +21454 RESULTS +21455 RESULTS +21456 RESULTS +21457 RESULTS +21458 CONCLUSIONS +21459 BACKGROUND +21460 OBJECTIVE +21461 METHODS +21462 METHODS +21463 RESULTS +21464 RESULTS +21465 RESULTS +21466 RESULTS +21467 CONCLUSIONS +21468 BACKGROUND +21469 BACKGROUND +21470 OBJECTIVE +21471 METHODS +21472 RESULTS +21473 RESULTS +21474 RESULTS +21475 RESULTS +21476 RESULTS +21477 RESULTS +21478 CONCLUSIONS +21479 CONCLUSIONS +21480 BACKGROUND +21481 BACKGROUND +21482 BACKGROUND +21483 OBJECTIVE +21484 METHODS +21485 METHODS +21486 RESULTS +21487 RESULTS +21488 CONCLUSIONS +21489 CONCLUSIONS +21490 CONCLUSIONS +21491 BACKGROUND +21492 CONCLUSIONS +21493 BACKGROUND +21494 RESULTS +21495 METHODS +21496 METHODS +21497 RESULTS +21498 RESULTS +21499 RESULTS +21500 RESULTS +21501 CONCLUSIONS +21502 CONCLUSIONS +21503 CONCLUSIONS +21504 OBJECTIVE +21505 METHODS +21506 METHODS +21507 METHODS +21508 RESULTS +21509 RESULTS +21510 RESULTS +21511 RESULTS +21512 RESULTS +21513 CONCLUSIONS +21514 CONCLUSIONS +21515 BACKGROUND +21516 BACKGROUND +21517 METHODS +21518 RESULTS +21519 RESULTS +21520 RESULTS +21521 RESULTS +21522 CONCLUSIONS +21523 CONCLUSIONS +21524 BACKGROUND +21525 METHODS +21526 METHODS +21527 RESULTS +21528 RESULTS +21529 RESULTS +21530 CONCLUSIONS +21531 OBJECTIVE +21532 METHODS +21533 METHODS +21534 METHODS +21535 METHODS +21536 METHODS +21537 METHODS +21538 RESULTS +21539 RESULTS +21540 RESULTS +21541 CONCLUSIONS +21542 CONCLUSIONS +21543 BACKGROUND +21544 BACKGROUND +21545 METHODS +21546 METHODS +21547 RESULTS +21548 RESULTS +21549 RESULTS +21550 RESULTS +21551 RESULTS +21552 RESULTS +21553 RESULTS +21554 CONCLUSIONS +21555 CONCLUSIONS +21556 BACKGROUND +21557 BACKGROUND +21558 METHODS +21559 METHODS +21560 METHODS +21561 METHODS +21562 RESULTS +21563 RESULTS +21564 RESULTS +21565 RESULTS +21566 CONCLUSIONS +21567 BACKGROUND +21568 OBJECTIVE +21569 METHODS +21570 METHODS +21571 RESULTS +21572 RESULTS +21573 RESULTS +21574 RESULTS +21575 RESULTS +21576 RESULTS +21577 RESULTS +21578 RESULTS +21579 CONCLUSIONS +21580 CONCLUSIONS +21581 BACKGROUND +21582 BACKGROUND +21583 BACKGROUND +21584 OBJECTIVE +21585 METHODS +21586 BACKGROUND +21587 METHODS +21588 METHODS +21589 RESULTS +21590 RESULTS +21591 CONCLUSIONS +21592 CONCLUSIONS +21593 OBJECTIVE +21594 METHODS +21595 RESULTS +21596 RESULTS +21597 RESULTS +21598 RESULTS +21599 CONCLUSIONS +21600 BACKGROUND +21601 BACKGROUND +21602 OBJECTIVE +21603 METHODS +21604 METHODS +21605 CONCLUSIONS +21606 RESULTS +21607 RESULTS +21608 RESULTS +21609 RESULTS +21610 RESULTS +21611 CONCLUSIONS +21612 BACKGROUND +21613 OBJECTIVE +21614 METHODS +21615 METHODS +21616 METHODS +21617 RESULTS +21618 RESULTS +21619 CONCLUSIONS +21620 CONCLUSIONS +21621 CONCLUSIONS +21622 OBJECTIVE +21623 BACKGROUND +21624 BACKGROUND +21625 OBJECTIVE +21626 METHODS +21627 METHODS +21628 METHODS +21629 METHODS +21630 METHODS +21631 METHODS +21632 RESULTS +21633 RESULTS +21634 RESULTS +21635 RESULTS +21636 RESULTS +21637 RESULTS +21638 RESULTS +21639 CONCLUSIONS +21640 RESULTS +21641 OBJECTIVE +21642 METHODS +21643 METHODS +21644 METHODS +21645 METHODS +21646 RESULTS +21647 METHODS +21648 RESULTS +21649 RESULTS +21650 RESULTS +21651 RESULTS +21652 RESULTS +21653 CONCLUSIONS +21654 BACKGROUND +21655 METHODS +21656 METHODS +21657 METHODS +21658 METHODS +21659 RESULTS +21660 RESULTS +21661 RESULTS +21662 CONCLUSIONS +21663 RESULTS +21664 CONCLUSIONS +21665 OBJECTIVE +21666 METHODS +21667 METHODS +21668 METHODS +21669 METHODS +21670 RESULTS +21671 RESULTS +21672 RESULTS +21673 METHODS +21674 RESULTS +21675 BACKGROUND +21676 OBJECTIVE +21677 METHODS +21678 RESULTS +21679 RESULTS +21680 CONCLUSIONS +21681 OBJECTIVE +21682 METHODS +21683 METHODS +21684 METHODS +21685 METHODS +21686 METHODS +21687 RESULTS +21688 RESULTS +21689 RESULTS +21690 CONCLUSIONS +21691 OBJECTIVE +21692 METHODS +21693 METHODS +21694 METHODS +21695 RESULTS +21696 RESULTS +21697 RESULTS +21698 RESULTS +21699 RESULTS +21700 RESULTS +21701 RESULTS +21702 RESULTS +21703 RESULTS +21704 CONCLUSIONS +21705 CONCLUSIONS +21706 OBJECTIVE +21707 METHODS +21708 METHODS +21709 METHODS +21710 METHODS +21711 METHODS +21712 METHODS +21713 METHODS +21714 METHODS +21715 RESULTS +21716 RESULTS +21717 RESULTS +21718 RESULTS +21719 CONCLUSIONS +21720 CONCLUSIONS +21721 CONCLUSIONS +21722 BACKGROUND +21723 BACKGROUND +21724 METHODS +21725 METHODS +21726 RESULTS +21727 RESULTS +21728 RESULTS +21729 RESULTS +21730 RESULTS +21731 RESULTS +21732 CONCLUSIONS +21733 BACKGROUND +21734 BACKGROUND +21735 BACKGROUND +21736 METHODS +21737 METHODS +21738 METHODS +21739 METHODS +21740 METHODS +21741 METHODS +21742 RESULTS +21743 RESULTS +21744 RESULTS +21745 RESULTS +21746 RESULTS +21747 RESULTS +21748 CONCLUSIONS +21749 BACKGROUND +21750 BACKGROUND +21751 OBJECTIVE +21752 METHODS +21753 METHODS +21754 METHODS +21755 RESULTS +21756 RESULTS +21757 RESULTS +21758 CONCLUSIONS +21759 RESULTS +21760 BACKGROUND +21761 BACKGROUND +21762 BACKGROUND +21763 BACKGROUND +21764 BACKGROUND +21765 METHODS +21766 METHODS +21767 METHODS +21768 METHODS +21769 METHODS +21770 METHODS +21771 METHODS +21772 RESULTS +21773 RESULTS +21774 RESULTS +21775 RESULTS +21776 RESULTS +21777 RESULTS +21778 CONCLUSIONS +21779 CONCLUSIONS +21780 BACKGROUND +21781 OBJECTIVE +21782 METHODS +21783 METHODS +21784 RESULTS +21785 RESULTS +21786 RESULTS +21787 CONCLUSIONS +21788 RESULTS +21789 CONCLUSIONS +21790 CONCLUSIONS +21791 CONCLUSIONS +21792 BACKGROUND +21793 BACKGROUND +21794 METHODS +21795 METHODS +21796 RESULTS +21797 RESULTS +21798 RESULTS +21799 RESULTS +21800 CONCLUSIONS +21801 CONCLUSIONS +21802 BACKGROUND +21803 BACKGROUND +21804 METHODS +21805 METHODS +21806 METHODS +21807 RESULTS +21808 RESULTS +21809 RESULTS +21810 RESULTS +21811 RESULTS +21812 RESULTS +21813 BACKGROUND +21814 CONCLUSIONS +21815 BACKGROUND +21816 CONCLUSIONS +21817 OBJECTIVE +21818 METHODS +21819 METHODS +21820 METHODS +21821 RESULTS +21822 RESULTS +21823 RESULTS +21824 RESULTS +21825 CONCLUSIONS +21826 CONCLUSIONS +21827 CONCLUSIONS +21828 BACKGROUND +21829 BACKGROUND +21830 OBJECTIVE +21831 METHODS +21832 METHODS +21833 METHODS +21834 METHODS +21835 RESULTS +21836 RESULTS +21837 RESULTS +21838 RESULTS +21839 RESULTS +21840 CONCLUSIONS +21841 RESULTS +21842 RESULTS +21843 BACKGROUND +21844 METHODS +21845 METHODS +21846 RESULTS +21847 RESULTS +21848 RESULTS +21849 RESULTS +21850 CONCLUSIONS +21851 BACKGROUND +21852 OBJECTIVE +21853 METHODS +21854 METHODS +21855 RESULTS +21856 RESULTS +21857 RESULTS +21858 RESULTS +21859 CONCLUSIONS +21860 CONCLUSIONS +21861 RESULTS +21862 CONCLUSIONS +21863 BACKGROUND +21864 BACKGROUND +21865 METHODS +21866 METHODS +21867 METHODS +21868 RESULTS +21869 RESULTS +21870 RESULTS +21871 RESULTS +21872 CONCLUSIONS +21873 CONCLUSIONS +21874 CONCLUSIONS +21875 BACKGROUND +21876 BACKGROUND +21877 BACKGROUND +21878 METHODS +21879 METHODS +21880 METHODS +21881 METHODS +21882 RESULTS +21883 RESULTS +21884 CONCLUSIONS +21885 CONCLUSIONS +21886 OBJECTIVE +21887 METHODS +21888 METHODS +21889 METHODS +21890 RESULTS +21891 RESULTS +21892 RESULTS +21893 CONCLUSIONS +21894 OBJECTIVE +21895 METHODS +21896 METHODS +21897 METHODS +21898 METHODS +21899 METHODS +21900 METHODS +21901 RESULTS +21902 RESULTS +21903 RESULTS +21904 RESULTS +21905 RESULTS +21906 RESULTS +21907 BACKGROUND +21908 OBJECTIVE +21909 METHODS +21910 METHODS +21911 METHODS +21912 METHODS +21913 RESULTS +21914 RESULTS +21915 RESULTS +21916 RESULTS +21917 RESULTS +21918 CONCLUSIONS +21919 RESULTS +21920 RESULTS +21921 RESULTS +21922 CONCLUSIONS +21923 CONCLUSIONS +21924 RESULTS +21925 BACKGROUND +21926 BACKGROUND +21927 METHODS +21928 METHODS +21929 METHODS +21930 METHODS +21931 METHODS +21932 METHODS +21933 METHODS +21934 RESULTS +21935 RESULTS +21936 RESULTS +21937 RESULTS +21938 CONCLUSIONS +21939 OBJECTIVE +21940 METHODS +21941 METHODS +21942 METHODS +21943 METHODS +21944 RESULTS +21945 RESULTS +21946 RESULTS +21947 CONCLUSIONS +21948 OBJECTIVE +21949 OBJECTIVE +21950 METHODS +21951 METHODS +21952 METHODS +21953 METHODS +21954 RESULTS +21955 RESULTS +21956 RESULTS +21957 RESULTS +21958 CONCLUSIONS +21959 CONCLUSIONS +21960 CONCLUSIONS +21961 OBJECTIVE +21962 METHODS +21963 METHODS +21964 METHODS +21965 METHODS +21966 RESULTS +21967 RESULTS +21968 RESULTS +21969 CONCLUSIONS +21970 CONCLUSIONS +21971 BACKGROUND +21972 BACKGROUND +21973 METHODS +21974 METHODS +21975 RESULTS +21976 RESULTS +21977 RESULTS +21978 RESULTS +21979 CONCLUSIONS +21980 BACKGROUND +21981 OBJECTIVE +21982 METHODS +21983 METHODS +21984 METHODS +21985 METHODS +21986 METHODS +21987 METHODS +21988 METHODS +21989 RESULTS +21990 RESULTS +21991 RESULTS +21992 RESULTS +21993 CONCLUSIONS +21994 CONCLUSIONS +21995 OBJECTIVE +21996 METHODS +21997 METHODS +21998 RESULTS +21999 RESULTS +22000 RESULTS +22001 RESULTS +22002 RESULTS +22003 CONCLUSIONS +22004 CONCLUSIONS +22005 BACKGROUND +22006 OBJECTIVE +22007 METHODS +22008 METHODS +22009 RESULTS +22010 RESULTS +22011 RESULTS +22012 RESULTS +22013 RESULTS +22014 CONCLUSIONS +22015 CONCLUSIONS +22016 CONCLUSIONS +22017 BACKGROUND +22018 BACKGROUND +22019 METHODS +22020 METHODS +22021 METHODS +22022 METHODS +22023 RESULTS +22024 RESULTS +22025 RESULTS +22026 RESULTS +22027 RESULTS +22028 RESULTS +22029 RESULTS +22030 CONCLUSIONS +22031 RESULTS +22032 OBJECTIVE +22033 METHODS +22034 METHODS +22035 METHODS +22036 METHODS +22037 RESULTS +22038 RESULTS +22039 RESULTS +22040 RESULTS +22041 RESULTS +22042 RESULTS +22043 RESULTS +22044 CONCLUSIONS +22045 RESULTS +22046 RESULTS +22047 RESULTS +22048 CONCLUSIONS +22049 BACKGROUND +22050 BACKGROUND +22051 RESULTS +22052 RESULTS +22053 RESULTS +22054 RESULTS +22055 RESULTS +22056 RESULTS +22057 RESULTS +22058 CONCLUSIONS +22059 RESULTS +22060 BACKGROUND +22061 BACKGROUND +22062 OBJECTIVE +22063 METHODS +22064 METHODS +22065 RESULTS +22066 RESULTS +22067 CONCLUSIONS +22068 CONCLUSIONS +22069 BACKGROUND +22070 BACKGROUND +22071 OBJECTIVE +22072 METHODS +22073 METHODS +22074 METHODS +22075 METHODS +22076 RESULTS +22077 RESULTS +22078 RESULTS +22079 RESULTS +22080 CONCLUSIONS +22081 RESULTS +22082 BACKGROUND +22083 BACKGROUND +22084 METHODS +22085 METHODS +22086 METHODS +22087 RESULTS +22088 RESULTS +22089 RESULTS +22090 CONCLUSIONS +22091 CONCLUSIONS +22092 OBJECTIVE +22093 METHODS +22094 METHODS +22095 METHODS +22096 METHODS +22097 RESULTS +22098 RESULTS +22099 RESULTS +22100 CONCLUSIONS +22101 OBJECTIVE +22102 METHODS +22103 RESULTS +22104 METHODS +22105 METHODS +22106 RESULTS +22107 RESULTS +22108 RESULTS +22109 RESULTS +22110 RESULTS +22111 CONCLUSIONS +22112 BACKGROUND +22113 OBJECTIVE +22114 METHODS +22115 RESULTS +22116 RESULTS +22117 RESULTS +22118 CONCLUSIONS +22119 CONCLUSIONS +22120 BACKGROUND +22121 BACKGROUND +22122 BACKGROUND +22123 METHODS +22124 RESULTS +22125 RESULTS +22126 RESULTS +22127 CONCLUSIONS +22128 CONCLUSIONS +22129 BACKGROUND +22130 OBJECTIVE +22131 METHODS +22132 METHODS +22133 RESULTS +22134 RESULTS +22135 RESULTS +22136 RESULTS +22137 RESULTS +22138 CONCLUSIONS +22139 CONCLUSIONS +22140 CONCLUSIONS +22141 OBJECTIVE +22142 METHODS +22143 METHODS +22144 METHODS +22145 METHODS +22146 METHODS +22147 METHODS +22148 RESULTS +22149 RESULTS +22150 RESULTS +22151 RESULTS +22152 CONCLUSIONS +22153 CONCLUSIONS +22154 OBJECTIVE +22155 METHODS +22156 METHODS +22157 METHODS +22158 METHODS +22159 RESULTS +22160 RESULTS +22161 RESULTS +22162 RESULTS +22163 CONCLUSIONS +22164 BACKGROUND +22165 BACKGROUND +22166 OBJECTIVE +22167 METHODS +22168 METHODS +22169 METHODS +22170 METHODS +22171 METHODS +22172 RESULTS +22173 RESULTS +22174 RESULTS +22175 RESULTS +22176 RESULTS +22177 RESULTS +22178 CONCLUSIONS +22179 RESULTS +22180 RESULTS +22181 CONCLUSIONS +22182 BACKGROUND +22183 BACKGROUND +22184 BACKGROUND +22185 METHODS +22186 RESULTS +22187 RESULTS +22188 RESULTS +22189 CONCLUSIONS +22190 BACKGROUND +22191 BACKGROUND +22192 RESULTS +22193 RESULTS +22194 RESULTS +22195 RESULTS +22196 RESULTS +22197 RESULTS +22198 RESULTS +22199 CONCLUSIONS +22200 BACKGROUND +22201 BACKGROUND +22202 OBJECTIVE +22203 OBJECTIVE +22204 METHODS +22205 METHODS +22206 METHODS +22207 METHODS +22208 METHODS +22209 RESULTS +22210 RESULTS +22211 RESULTS +22212 RESULTS +22213 RESULTS +22214 CONCLUSIONS +22215 OBJECTIVE +22216 CONCLUSIONS +22217 METHODS +22218 METHODS +22219 METHODS +22220 METHODS +22221 METHODS +22222 METHODS +22223 METHODS +22224 RESULTS +22225 RESULTS +22226 CONCLUSIONS +22227 CONCLUSIONS +22228 CONCLUSIONS +22229 BACKGROUND +22230 BACKGROUND +22231 METHODS +22232 METHODS +22233 METHODS +22234 METHODS +22235 METHODS +22236 RESULTS +22237 RESULTS +22238 RESULTS +22239 CONCLUSIONS +22240 OBJECTIVE +22241 METHODS +22242 METHODS +22243 METHODS +22244 METHODS +22245 METHODS +22246 METHODS +22247 METHODS +22248 METHODS +22249 METHODS +22250 RESULTS +22251 RESULTS +22252 CONCLUSIONS +22253 CONCLUSIONS +22254 OBJECTIVE +22255 OBJECTIVE +22256 METHODS +22257 METHODS +22258 RESULTS +22259 RESULTS +22260 RESULTS +22261 CONCLUSIONS +22262 BACKGROUND +22263 BACKGROUND +22264 BACKGROUND +22265 OBJECTIVE +22266 OBJECTIVE +22267 METHODS +22268 METHODS +22269 METHODS +22270 METHODS +22271 RESULTS +22272 METHODS +22273 METHODS +22274 RESULTS +22275 RESULTS +22276 CONCLUSIONS +22277 OBJECTIVE +22278 METHODS +22279 METHODS +22280 RESULTS +22281 RESULTS +22282 RESULTS +22283 RESULTS +22284 RESULTS +22285 RESULTS +22286 RESULTS +22287 CONCLUSIONS +22288 OBJECTIVE +22289 METHODS +22290 METHODS +22291 METHODS +22292 RESULTS +22293 RESULTS +22294 RESULTS +22295 RESULTS +22296 RESULTS +22297 CONCLUSIONS +22298 RESULTS +22299 BACKGROUND +22300 CONCLUSIONS +22301 METHODS +22302 METHODS +22303 OBJECTIVE +22304 RESULTS +22305 RESULTS +22306 RESULTS +22307 RESULTS +22308 CONCLUSIONS +22309 BACKGROUND +22310 BACKGROUND +22311 OBJECTIVE +22312 METHODS +22313 METHODS +22314 METHODS +22315 METHODS +22316 METHODS +22317 METHODS +22318 RESULTS +22319 RESULTS +22320 RESULTS +22321 RESULTS +22322 RESULTS +22323 RESULTS +22324 CONCLUSIONS +22325 CONCLUSIONS +22326 CONCLUSIONS +22327 OBJECTIVE +22328 BACKGROUND +22329 METHODS +22330 METHODS +22331 METHODS +22332 RESULTS +22333 RESULTS +22334 RESULTS +22335 RESULTS +22336 CONCLUSIONS +22337 CONCLUSIONS +22338 OBJECTIVE +22339 METHODS +22340 METHODS +22341 METHODS +22342 METHODS +22343 METHODS +22344 RESULTS +22345 RESULTS +22346 RESULTS +22347 CONCLUSIONS +22348 CONCLUSIONS +22349 BACKGROUND +22350 BACKGROUND +22351 BACKGROUND +22352 METHODS +22353 METHODS +22354 RESULTS +22355 RESULTS +22356 RESULTS +22357 RESULTS +22358 RESULTS +22359 CONCLUSIONS +22360 CONCLUSIONS +22361 OBJECTIVE +22362 METHODS +22363 METHODS +22364 METHODS +22365 METHODS +22366 METHODS +22367 RESULTS +22368 RESULTS +22369 RESULTS +22370 RESULTS +22371 CONCLUSIONS +22372 CONCLUSIONS +22373 BACKGROUND +22374 BACKGROUND +22375 BACKGROUND +22376 METHODS +22377 METHODS +22378 RESULTS +22379 RESULTS +22380 RESULTS +22381 RESULTS +22382 RESULTS +22383 RESULTS +22384 RESULTS +22385 CONCLUSIONS +22386 OBJECTIVE +22387 METHODS +22388 METHODS +22389 METHODS +22390 RESULTS +22391 RESULTS +22392 RESULTS +22393 CONCLUSIONS +22394 OBJECTIVE +22395 OBJECTIVE +22396 METHODS +22397 METHODS +22398 METHODS +22399 METHODS +22400 RESULTS +22401 CONCLUSIONS +22402 OBJECTIVE +22403 METHODS +22404 METHODS +22405 METHODS +22406 METHODS +22407 METHODS +22408 RESULTS +22409 RESULTS +22410 RESULTS +22411 RESULTS +22412 RESULTS +22413 CONCLUSIONS +22414 OBJECTIVE +22415 METHODS +22416 RESULTS +22417 RESULTS +22418 RESULTS +22419 CONCLUSIONS +22420 RESULTS +22421 CONCLUSIONS +22422 CONCLUSIONS +22423 CONCLUSIONS +22424 RESULTS +22425 RESULTS +22426 BACKGROUND +22427 OBJECTIVE +22428 BACKGROUND +22429 METHODS +22430 METHODS +22431 METHODS +22432 RESULTS +22433 RESULTS +22434 RESULTS +22435 CONCLUSIONS +22436 CONCLUSIONS +22437 BACKGROUND +22438 METHODS +22439 METHODS +22440 METHODS +22441 RESULTS +22442 RESULTS +22443 CONCLUSIONS +22444 BACKGROUND +22445 BACKGROUND +22446 BACKGROUND +22447 BACKGROUND +22448 BACKGROUND +22449 BACKGROUND +22450 METHODS +22451 METHODS +22452 METHODS +22453 METHODS +22454 RESULTS +22455 RESULTS +22456 RESULTS +22457 RESULTS +22458 CONCLUSIONS +22459 CONCLUSIONS +22460 BACKGROUND +22461 BACKGROUND +22462 BACKGROUND +22463 BACKGROUND +22464 BACKGROUND +22465 METHODS +22466 METHODS +22467 METHODS +22468 METHODS +22469 METHODS +22470 CONCLUSIONS +22471 CONCLUSIONS +22472 METHODS +22473 BACKGROUND +22474 BACKGROUND +22475 METHODS +22476 RESULTS +22477 RESULTS +22478 RESULTS +22479 RESULTS +22480 CONCLUSIONS +22481 CONCLUSIONS +22482 OBJECTIVE +22483 METHODS +22484 METHODS +22485 METHODS +22486 METHODS +22487 METHODS +22488 RESULTS +22489 RESULTS +22490 RESULTS +22491 CONCLUSIONS +22492 CONCLUSIONS +22493 OBJECTIVE +22494 METHODS +22495 METHODS +22496 METHODS +22497 RESULTS +22498 RESULTS +22499 RESULTS +22500 RESULTS +22501 RESULTS +22502 RESULTS +22503 CONCLUSIONS +22504 CONCLUSIONS +22505 OBJECTIVE +22506 METHODS +22507 METHODS +22508 METHODS +22509 METHODS +22510 METHODS +22511 METHODS +22512 RESULTS +22513 RESULTS +22514 RESULTS +22515 RESULTS +22516 CONCLUSIONS +22517 OBJECTIVE +22518 METHODS +22519 METHODS +22520 METHODS +22521 METHODS +22522 METHODS +22523 METHODS +22524 RESULTS +22525 RESULTS +22526 RESULTS +22527 RESULTS +22528 RESULTS +22529 RESULTS +22530 RESULTS +22531 CONCLUSIONS +22532 BACKGROUND +22533 OBJECTIVE +22534 METHODS +22535 METHODS +22536 RESULTS +22537 RESULTS +22538 CONCLUSIONS +22539 CONCLUSIONS +22540 CONCLUSIONS +22541 OBJECTIVE +22542 METHODS +22543 METHODS +22544 METHODS +22545 METHODS +22546 RESULTS +22547 RESULTS +22548 RESULTS +22549 RESULTS +22550 CONCLUSIONS +22551 CONCLUSIONS +22552 BACKGROUND +22553 OBJECTIVE +22554 METHODS +22555 METHODS +22556 METHODS +22557 RESULTS +22558 RESULTS +22559 RESULTS +22560 RESULTS +22561 RESULTS +22562 RESULTS +22563 RESULTS +22564 RESULTS +22565 CONCLUSIONS +22566 CONCLUSIONS +22567 CONCLUSIONS +22568 BACKGROUND +22569 BACKGROUND +22570 METHODS +22571 METHODS +22572 METHODS +22573 METHODS +22574 RESULTS +22575 RESULTS +22576 RESULTS +22577 CONCLUSIONS +22578 OBJECTIVE +22579 METHODS +22580 METHODS +22581 METHODS +22582 RESULTS +22583 RESULTS +22584 CONCLUSIONS +22585 OBJECTIVE +22586 METHODS +22587 METHODS +22588 METHODS +22589 METHODS +22590 METHODS +22591 METHODS +22592 RESULTS +22593 RESULTS +22594 RESULTS +22595 RESULTS +22596 CONCLUSIONS +22597 BACKGROUND +22598 METHODS +22599 METHODS +22600 METHODS +22601 METHODS +22602 RESULTS +22603 RESULTS +22604 CONCLUSIONS +22605 RESULTS +22606 CONCLUSIONS +22607 CONCLUSIONS +22608 BACKGROUND +22609 BACKGROUND +22610 CONCLUSIONS +22611 BACKGROUND +22612 METHODS +22613 METHODS +22614 RESULTS +22615 RESULTS +22616 RESULTS +22617 RESULTS +22618 RESULTS +22619 CONCLUSIONS +22620 RESULTS +22621 RESULTS +22622 CONCLUSIONS +22623 CONCLUSIONS +22624 OBJECTIVE +22625 OBJECTIVE +22626 METHODS +22627 RESULTS +22628 RESULTS +22629 METHODS +22630 RESULTS +22631 RESULTS +22632 RESULTS +22633 RESULTS +22634 RESULTS +22635 CONCLUSIONS +22636 CONCLUSIONS +22637 CONCLUSIONS +22638 OBJECTIVE +22639 METHODS +22640 METHODS +22641 RESULTS +22642 RESULTS +22643 RESULTS +22644 RESULTS +22645 CONCLUSIONS +22646 CONCLUSIONS +22647 CONCLUSIONS +22648 OBJECTIVE +22649 METHODS +22650 METHODS +22651 METHODS +22652 RESULTS +22653 RESULTS +22654 RESULTS +22655 RESULTS +22656 RESULTS +22657 RESULTS +22658 CONCLUSIONS +22659 BACKGROUND +22660 BACKGROUND +22661 BACKGROUND +22662 OBJECTIVE +22663 METHODS +22664 METHODS +22665 METHODS +22666 METHODS +22667 METHODS +22668 RESULTS +22669 RESULTS +22670 RESULTS +22671 RESULTS +22672 RESULTS +22673 CONCLUSIONS +22674 OBJECTIVE +22675 METHODS +22676 METHODS +22677 METHODS +22678 METHODS +22679 METHODS +22680 RESULTS +22681 RESULTS +22682 RESULTS +22683 RESULTS +22684 CONCLUSIONS +22685 OBJECTIVE +22686 METHODS +22687 METHODS +22688 METHODS +22689 RESULTS +22690 METHODS +22691 METHODS +22692 METHODS +22693 METHODS +22694 RESULTS +22695 RESULTS +22696 CONCLUSIONS +22697 METHODS +22698 METHODS +22699 METHODS +22700 METHODS +22701 METHODS +22702 RESULTS +22703 RESULTS +22704 CONCLUSIONS +22705 RESULTS +22706 RESULTS +22707 RESULTS +22708 RESULTS +22709 CONCLUSIONS +22710 CONCLUSIONS +22711 BACKGROUND +22712 BACKGROUND +22713 BACKGROUND +22714 CONCLUSIONS +22715 OBJECTIVE +22716 METHODS +22717 METHODS +22718 RESULTS +22719 RESULTS +22720 RESULTS +22721 CONCLUSIONS +22722 BACKGROUND +22723 BACKGROUND +22724 OBJECTIVE +22725 METHODS +22726 METHODS +22727 METHODS +22728 METHODS +22729 METHODS +22730 METHODS +22731 RESULTS +22732 RESULTS +22733 RESULTS +22734 RESULTS +22735 CONCLUSIONS +22736 CONCLUSIONS +22737 BACKGROUND +22738 OBJECTIVE +22739 METHODS +22740 METHODS +22741 METHODS +22742 METHODS +22743 RESULTS +22744 RESULTS +22745 CONCLUSIONS +22746 BACKGROUND +22747 BACKGROUND +22748 OBJECTIVE +22749 OBJECTIVE +22750 METHODS +22751 METHODS +22752 RESULTS +22753 RESULTS +22754 CONCLUSIONS +22755 CONCLUSIONS +22756 BACKGROUND +22757 BACKGROUND +22758 OBJECTIVE +22759 METHODS +22760 METHODS +22761 METHODS +22762 METHODS +22763 METHODS +22764 RESULTS +22765 RESULTS +22766 RESULTS +22767 RESULTS +22768 CONCLUSIONS +22769 BACKGROUND +22770 OBJECTIVE +22771 METHODS +22772 METHODS +22773 METHODS +22774 METHODS +22775 METHODS +22776 RESULTS +22777 RESULTS +22778 RESULTS +22779 CONCLUSIONS +22780 OBJECTIVE +22781 METHODS +22782 METHODS +22783 METHODS +22784 METHODS +22785 METHODS +22786 RESULTS +22787 RESULTS +22788 RESULTS +22789 CONCLUSIONS +22790 CONCLUSIONS +22791 CONCLUSIONS +22792 BACKGROUND +22793 BACKGROUND +22794 METHODS +22795 METHODS +22796 RESULTS +22797 RESULTS +22798 RESULTS +22799 RESULTS +22800 RESULTS +22801 RESULTS +22802 CONCLUSIONS +22803 BACKGROUND +22804 OBJECTIVE +22805 METHODS +22806 METHODS +22807 METHODS +22808 RESULTS +22809 RESULTS +22810 CONCLUSIONS +22811 OBJECTIVE +22812 METHODS +22813 METHODS +22814 RESULTS +22815 RESULTS +22816 RESULTS +22817 RESULTS +22818 RESULTS +22819 RESULTS +22820 BACKGROUND +22821 OBJECTIVE +22822 METHODS +22823 METHODS +22824 METHODS +22825 METHODS +22826 RESULTS +22827 RESULTS +22828 RESULTS +22829 RESULTS +22830 RESULTS +22831 RESULTS +22832 RESULTS +22833 RESULTS +22834 RESULTS +22835 BACKGROUND +22836 METHODS +22837 METHODS +22838 METHODS +22839 METHODS +22840 RESULTS +22841 RESULTS +22842 RESULTS +22843 RESULTS +22844 RESULTS +22845 RESULTS +22846 RESULTS +22847 BACKGROUND +22848 BACKGROUND +22849 BACKGROUND +22850 OBJECTIVE +22851 METHODS +22852 METHODS +22853 RESULTS +22854 METHODS +22855 METHODS +22856 RESULTS +22857 RESULTS +22858 RESULTS +22859 CONCLUSIONS +22860 RESULTS +22861 BACKGROUND +22862 BACKGROUND +22863 BACKGROUND +22864 METHODS +22865 METHODS +22866 METHODS +22867 RESULTS +22868 RESULTS +22869 RESULTS +22870 RESULTS +22871 RESULTS +22872 CONCLUSIONS +22873 CONCLUSIONS +22874 CONCLUSIONS +22875 CONCLUSIONS +22876 OBJECTIVE +22877 METHODS +22878 METHODS +22879 RESULTS +22880 RESULTS +22881 RESULTS +22882 RESULTS +22883 RESULTS +22884 CONCLUSIONS +22885 CONCLUSIONS +22886 BACKGROUND +22887 BACKGROUND +22888 RESULTS +22889 METHODS +22890 RESULTS +22891 RESULTS +22892 RESULTS +22893 CONCLUSIONS +22894 CONCLUSIONS +22895 CONCLUSIONS +22896 BACKGROUND +22897 BACKGROUND +22898 OBJECTIVE +22899 METHODS +22900 METHODS +22901 RESULTS +22902 RESULTS +22903 RESULTS +22904 METHODS +22905 CONCLUSIONS +22906 OBJECTIVE +22907 METHODS +22908 METHODS +22909 RESULTS +22910 CONCLUSIONS +22911 CONCLUSIONS +22912 OBJECTIVE +22913 METHODS +22914 METHODS +22915 METHODS +22916 METHODS +22917 RESULTS +22918 RESULTS +22919 RESULTS +22920 RESULTS +22921 RESULTS +22922 RESULTS +22923 CONCLUSIONS +22924 CONCLUSIONS +22925 BACKGROUND +22926 OBJECTIVE +22927 OBJECTIVE +22928 OBJECTIVE +22929 OBJECTIVE +22930 METHODS +22931 METHODS +22932 METHODS +22933 RESULTS +22934 RESULTS +22935 RESULTS +22936 METHODS +22937 RESULTS +22938 RESULTS +22939 RESULTS +22940 RESULTS +22941 RESULTS +22942 CONCLUSIONS +22943 METHODS +22944 METHODS +22945 METHODS +22946 METHODS +22947 METHODS +22948 RESULTS +22949 RESULTS +22950 RESULTS +22951 CONCLUSIONS +22952 OBJECTIVE +22953 METHODS +22954 METHODS +22955 METHODS +22956 METHODS +22957 METHODS +22958 RESULTS +22959 RESULTS +22960 RESULTS +22961 RESULTS +22962 RESULTS +22963 CONCLUSIONS +22964 OBJECTIVE +22965 METHODS +22966 METHODS +22967 RESULTS +22968 CONCLUSIONS +22969 OBJECTIVE +22970 METHODS +22971 METHODS +22972 METHODS +22973 METHODS +22974 RESULTS +22975 RESULTS +22976 RESULTS +22977 CONCLUSIONS +22978 CONCLUSIONS +22979 BACKGROUND +22980 BACKGROUND +22981 METHODS +22982 METHODS +22983 RESULTS +22984 RESULTS +22985 RESULTS +22986 RESULTS +22987 RESULTS +22988 RESULTS +22989 RESULTS +22990 CONCLUSIONS +22991 CONCLUSIONS +22992 CONCLUSIONS +22993 BACKGROUND +22994 METHODS +22995 RESULTS +22996 METHODS +22997 METHODS +22998 RESULTS +22999 RESULTS +23000 RESULTS +23001 RESULTS +23002 RESULTS +23003 CONCLUSIONS +23004 OBJECTIVE +23005 METHODS +23006 METHODS +23007 METHODS +23008 METHODS +23009 RESULTS +23010 RESULTS +23011 RESULTS +23012 CONCLUSIONS +23013 CONCLUSIONS +23014 CONCLUSIONS +23015 OBJECTIVE +23016 METHODS +23017 METHODS +23018 METHODS +23019 RESULTS +23020 RESULTS +23021 RESULTS +23022 RESULTS +23023 RESULTS +23024 RESULTS +23025 CONCLUSIONS +23026 CONCLUSIONS +23027 CONCLUSIONS +23028 BACKGROUND +23029 BACKGROUND +23030 BACKGROUND +23031 METHODS +23032 METHODS +23033 METHODS +23034 RESULTS +23035 RESULTS +23036 RESULTS +23037 CONCLUSIONS +23038 RESULTS +23039 OBJECTIVE +23040 METHODS +23041 METHODS +23042 METHODS +23043 METHODS +23044 METHODS +23045 RESULTS +23046 RESULTS +23047 RESULTS +23048 RESULTS +23049 RESULTS +23050 RESULTS +23051 RESULTS +23052 RESULTS +23053 CONCLUSIONS +23054 CONCLUSIONS +23055 CONCLUSIONS +23056 CONCLUSIONS +23057 OBJECTIVE +23058 METHODS +23059 METHODS +23060 METHODS +23061 METHODS +23062 RESULTS +23063 RESULTS +23064 RESULTS +23065 RESULTS +23066 CONCLUSIONS +23067 OBJECTIVE +23068 METHODS +23069 METHODS +23070 METHODS +23071 RESULTS +23072 RESULTS +23073 CONCLUSIONS +23074 BACKGROUND +23075 BACKGROUND +23076 OBJECTIVE +23077 METHODS +23078 METHODS +23079 RESULTS +23080 RESULTS +23081 RESULTS +23082 CONCLUSIONS +23083 OBJECTIVE +23084 METHODS +23085 METHODS +23086 METHODS +23087 METHODS +23088 METHODS +23089 METHODS +23090 RESULTS +23091 METHODS +23092 METHODS +23093 METHODS +23094 RESULTS +23095 RESULTS +23096 RESULTS +23097 RESULTS +23098 RESULTS +23099 RESULTS +23100 RESULTS +23101 BACKGROUND +23102 CONCLUSIONS +23103 CONCLUSIONS +23104 OBJECTIVE +23105 METHODS +23106 METHODS +23107 METHODS +23108 METHODS +23109 METHODS +23110 METHODS +23111 RESULTS +23112 RESULTS +23113 RESULTS +23114 RESULTS +23115 RESULTS +23116 RESULTS +23117 RESULTS +23118 RESULTS +23119 RESULTS +23120 RESULTS +23121 RESULTS +23122 RESULTS +23123 CONCLUSIONS +23124 CONCLUSIONS +23125 CONCLUSIONS +23126 CONCLUSIONS +23127 CONCLUSIONS +23128 CONCLUSIONS +23129 CONCLUSIONS +23130 BACKGROUND +23131 BACKGROUND +23132 METHODS +23133 METHODS +23134 METHODS +23135 METHODS +23136 METHODS +23137 METHODS +23138 METHODS +23139 RESULTS +23140 METHODS +23141 RESULTS +23142 RESULTS +23143 RESULTS +23144 RESULTS +23145 RESULTS +23146 CONCLUSIONS +23147 BACKGROUND +23148 BACKGROUND +23149 METHODS +23150 RESULTS +23151 RESULTS +23152 RESULTS +23153 RESULTS +23154 CONCLUSIONS +23155 OBJECTIVE +23156 METHODS +23157 METHODS +23158 METHODS +23159 METHODS +23160 RESULTS +23161 RESULTS +23162 RESULTS +23163 RESULTS +23164 RESULTS +23165 CONCLUSIONS +23166 BACKGROUND +23167 OBJECTIVE +23168 OBJECTIVE +23169 METHODS +23170 METHODS +23171 METHODS +23172 RESULTS +23173 RESULTS +23174 RESULTS +23175 RESULTS +23176 CONCLUSIONS +23177 BACKGROUND +23178 BACKGROUND +23179 OBJECTIVE +23180 METHODS +23181 METHODS +23182 METHODS +23183 RESULTS +23184 RESULTS +23185 CONCLUSIONS +23186 RESULTS +23187 OBJECTIVE +23188 METHODS +23189 METHODS +23190 METHODS +23191 CONCLUSIONS +23192 RESULTS +23193 CONCLUSIONS +23194 BACKGROUND +23195 BACKGROUND +23196 METHODS +23197 METHODS +23198 METHODS +23199 METHODS +23200 METHODS +23201 METHODS +23202 RESULTS +23203 RESULTS +23204 RESULTS +23205 RESULTS +23206 RESULTS +23207 RESULTS +23208 RESULTS +23209 METHODS +23210 RESULTS +23211 BACKGROUND +23212 RESULTS +23213 CONCLUSIONS +23214 OBJECTIVE +23215 METHODS +23216 METHODS +23217 METHODS +23218 METHODS +23219 METHODS +23220 METHODS +23221 METHODS +23222 RESULTS +23223 RESULTS +23224 RESULTS +23225 OBJECTIVE +23226 METHODS +23227 METHODS +23228 METHODS +23229 RESULTS +23230 RESULTS +23231 RESULTS +23232 RESULTS +23233 RESULTS +23234 RESULTS +23235 CONCLUSIONS +23236 CONCLUSIONS +23237 BACKGROUND +23238 CONCLUSIONS +23239 METHODS +23240 METHODS +23241 METHODS +23242 METHODS +23243 METHODS +23244 CONCLUSIONS +23245 RESULTS +23246 RESULTS +23247 CONCLUSIONS +23248 CONCLUSIONS +23249 OBJECTIVE +23250 METHODS +23251 METHODS +23252 RESULTS +23253 RESULTS +23254 RESULTS +23255 CONCLUSIONS +23256 OBJECTIVE +23257 METHODS +23258 METHODS +23259 RESULTS +23260 RESULTS +23261 METHODS +23262 RESULTS +23263 RESULTS +23264 RESULTS +23265 CONCLUSIONS +23266 OBJECTIVE +23267 METHODS +23268 METHODS +23269 METHODS +23270 METHODS +23271 RESULTS +23272 RESULTS +23273 RESULTS +23274 CONCLUSIONS +23275 OBJECTIVE +23276 METHODS +23277 METHODS +23278 METHODS +23279 BACKGROUND +23280 METHODS +23281 RESULTS +23282 RESULTS +23283 RESULTS +23284 RESULTS +23285 RESULTS +23286 CONCLUSIONS +23287 BACKGROUND +23288 METHODS +23289 OBJECTIVE +23290 METHODS +23291 METHODS +23292 METHODS +23293 RESULTS +23294 RESULTS +23295 RESULTS +23296 RESULTS +23297 RESULTS +23298 RESULTS +23299 RESULTS +23300 RESULTS +23301 RESULTS +23302 CONCLUSIONS +23303 CONCLUSIONS +23304 CONCLUSIONS +23305 BACKGROUND +23306 BACKGROUND +23307 METHODS +23308 RESULTS +23309 RESULTS +23310 RESULTS +23311 RESULTS +23312 CONCLUSIONS +23313 CONCLUSIONS +23314 OBJECTIVE +23315 METHODS +23316 METHODS +23317 METHODS +23318 RESULTS +23319 RESULTS +23320 RESULTS +23321 CONCLUSIONS +23322 OBJECTIVE +23323 METHODS +23324 METHODS +23325 METHODS +23326 METHODS +23327 METHODS +23328 METHODS +23329 RESULTS +23330 RESULTS +23331 RESULTS +23332 CONCLUSIONS +23333 CONCLUSIONS +23334 OBJECTIVE +23335 OBJECTIVE +23336 RESULTS +23337 METHODS +23338 METHODS +23339 METHODS +23340 CONCLUSIONS +23341 RESULTS +23342 CONCLUSIONS +23343 CONCLUSIONS +23344 CONCLUSIONS +23345 CONCLUSIONS +23346 OBJECTIVE +23347 CONCLUSIONS +23348 METHODS +23349 OBJECTIVE +23350 RESULTS +23351 RESULTS +23352 RESULTS +23353 RESULTS +23354 CONCLUSIONS +23355 CONCLUSIONS +23356 BACKGROUND +23357 BACKGROUND +23358 METHODS +23359 METHODS +23360 METHODS +23361 RESULTS +23362 RESULTS +23363 RESULTS +23364 RESULTS +23365 CONCLUSIONS +23366 CONCLUSIONS +23367 BACKGROUND +23368 OBJECTIVE +23369 METHODS +23370 METHODS +23371 METHODS +23372 RESULTS +23373 RESULTS +23374 RESULTS +23375 RESULTS +23376 RESULTS +23377 CONCLUSIONS +23378 BACKGROUND +23379 BACKGROUND +23380 METHODS +23381 RESULTS +23382 RESULTS +23383 RESULTS +23384 CONCLUSIONS +23385 OBJECTIVE +23386 OBJECTIVE +23387 METHODS +23388 METHODS +23389 METHODS +23390 RESULTS +23391 RESULTS +23392 RESULTS +23393 CONCLUSIONS +23394 CONCLUSIONS +23395 OBJECTIVE +23396 METHODS +23397 METHODS +23398 RESULTS +23399 METHODS +23400 RESULTS +23401 RESULTS +23402 CONCLUSIONS +23403 CONCLUSIONS +23404 BACKGROUND +23405 BACKGROUND +23406 BACKGROUND +23407 BACKGROUND +23408 METHODS +23409 METHODS +23410 METHODS +23411 RESULTS +23412 RESULTS +23413 RESULTS +23414 METHODS +23415 RESULTS +23416 RESULTS +23417 RESULTS +23418 CONCLUSIONS +23419 BACKGROUND +23420 OBJECTIVE +23421 METHODS +23422 BACKGROUND +23423 BACKGROUND +23424 OBJECTIVE +23425 BACKGROUND +23426 OBJECTIVE +23427 CONCLUSIONS +23428 OBJECTIVE +23429 CONCLUSIONS +23430 OBJECTIVE +23431 METHODS +23432 METHODS +23433 METHODS +23434 METHODS +23435 METHODS +23436 RESULTS +23437 RESULTS +23438 RESULTS +23439 RESULTS +23440 RESULTS +23441 RESULTS +23442 CONCLUSIONS +23443 CONCLUSIONS +23444 OBJECTIVE +23445 METHODS +23446 METHODS +23447 RESULTS +23448 RESULTS +23449 CONCLUSIONS +23450 CONCLUSIONS +23451 CONCLUSIONS +23452 OBJECTIVE +23453 METHODS +23454 METHODS +23455 METHODS +23456 RESULTS +23457 RESULTS +23458 BACKGROUND +23459 METHODS +23460 METHODS +23461 METHODS +23462 METHODS +23463 METHODS +23464 CONCLUSIONS +23465 METHODS +23466 RESULTS +23467 RESULTS +23468 RESULTS +23469 RESULTS +23470 RESULTS +23471 RESULTS +23472 CONCLUSIONS +23473 CONCLUSIONS +23474 OBJECTIVE +23475 METHODS +23476 METHODS +23477 RESULTS +23478 RESULTS +23479 RESULTS +23480 RESULTS +23481 RESULTS +23482 RESULTS +23483 RESULTS +23484 RESULTS +23485 RESULTS +23486 BACKGROUND +23487 OBJECTIVE +23488 BACKGROUND +23489 METHODS +23490 METHODS +23491 METHODS +23492 RESULTS +23493 RESULTS +23494 RESULTS +23495 RESULTS +23496 RESULTS +23497 BACKGROUND +23498 BACKGROUND +23499 BACKGROUND +23500 BACKGROUND +23501 BACKGROUND +23502 OBJECTIVE +23503 METHODS +23504 RESULTS +23505 RESULTS +23506 RESULTS +23507 RESULTS +23508 CONCLUSIONS +23509 RESULTS +23510 CONCLUSIONS +23511 OBJECTIVE +23512 METHODS +23513 METHODS +23514 METHODS +23515 RESULTS +23516 RESULTS +23517 RESULTS +23518 CONCLUSIONS +23519 RESULTS +23520 METHODS +23521 BACKGROUND +23522 OBJECTIVE +23523 METHODS +23524 METHODS +23525 METHODS +23526 METHODS +23527 RESULTS +23528 RESULTS +23529 RESULTS +23530 RESULTS +23531 RESULTS +23532 RESULTS +23533 RESULTS +23534 CONCLUSIONS +23535 BACKGROUND +23536 OBJECTIVE +23537 METHODS +23538 METHODS +23539 METHODS +23540 RESULTS +23541 RESULTS +23542 RESULTS +23543 RESULTS +23544 RESULTS +23545 RESULTS +23546 BACKGROUND +23547 OBJECTIVE +23548 METHODS +23549 RESULTS +23550 RESULTS +23551 CONCLUSIONS +23552 CONCLUSIONS +23553 BACKGROUND +23554 OBJECTIVE +23555 METHODS +23556 METHODS +23557 METHODS +23558 RESULTS +23559 RESULTS +23560 RESULTS +23561 RESULTS +23562 RESULTS +23563 CONCLUSIONS +23564 CONCLUSIONS +23565 BACKGROUND +23566 OBJECTIVE +23567 METHODS +23568 RESULTS +23569 RESULTS +23570 RESULTS +23571 RESULTS +23572 RESULTS +23573 CONCLUSIONS +23574 BACKGROUND +23575 BACKGROUND +23576 METHODS +23577 METHODS +23578 METHODS +23579 METHODS +23580 RESULTS +23581 RESULTS +23582 RESULTS +23583 RESULTS +23584 CONCLUSIONS +23585 OBJECTIVE +23586 METHODS +23587 METHODS +23588 METHODS +23589 METHODS +23590 METHODS +23591 RESULTS +23592 RESULTS +23593 CONCLUSIONS +23594 CONCLUSIONS +23595 BACKGROUND +23596 BACKGROUND +23597 OBJECTIVE +23598 METHODS +23599 METHODS +23600 METHODS +23601 METHODS +23602 METHODS +23603 RESULTS +23604 RESULTS +23605 RESULTS +23606 CONCLUSIONS +23607 BACKGROUND +23608 BACKGROUND +23609 BACKGROUND +23610 METHODS +23611 METHODS +23612 METHODS +23613 RESULTS +23614 RESULTS +23615 RESULTS +23616 RESULTS +23617 RESULTS +23618 RESULTS +23619 RESULTS +23620 CONCLUSIONS +23621 CONCLUSIONS +23622 CONCLUSIONS +23623 BACKGROUND +23624 BACKGROUND +23625 METHODS +23626 METHODS +23627 METHODS +23628 METHODS +23629 RESULTS +23630 RESULTS +23631 RESULTS +23632 RESULTS +23633 CONCLUSIONS +23634 CONCLUSIONS +23635 BACKGROUND +23636 BACKGROUND +23637 BACKGROUND +23638 METHODS +23639 METHODS +23640 METHODS +23641 METHODS +23642 METHODS +23643 RESULTS +23644 RESULTS +23645 RESULTS +23646 RESULTS +23647 CONCLUSIONS +23648 CONCLUSIONS +23649 BACKGROUND +23650 OBJECTIVE +23651 METHODS +23652 RESULTS +23653 RESULTS +23654 CONCLUSIONS +23655 BACKGROUND +23656 BACKGROUND +23657 BACKGROUND +23658 METHODS +23659 METHODS +23660 METHODS +23661 RESULTS +23662 RESULTS +23663 RESULTS +23664 CONCLUSIONS +23665 CONCLUSIONS +23666 BACKGROUND +23667 BACKGROUND +23668 METHODS +23669 METHODS +23670 METHODS +23671 METHODS +23672 METHODS +23673 METHODS +23674 METHODS +23675 RESULTS +23676 RESULTS +23677 RESULTS +23678 RESULTS +23679 RESULTS +23680 RESULTS +23681 CONCLUSIONS +23682 BACKGROUND +23683 BACKGROUND +23684 METHODS +23685 METHODS +23686 METHODS +23687 RESULTS +23688 RESULTS +23689 RESULTS +23690 CONCLUSIONS +23691 CONCLUSIONS +23692 OBJECTIVE +23693 METHODS +23694 METHODS +23695 METHODS +23696 METHODS +23697 METHODS +23698 RESULTS +23699 RESULTS +23700 RESULTS +23701 CONCLUSIONS +23702 OBJECTIVE +23703 METHODS +23704 METHODS +23705 RESULTS +23706 RESULTS +23707 RESULTS +23708 CONCLUSIONS +23709 CONCLUSIONS +23710 OBJECTIVE +23711 METHODS +23712 METHODS +23713 METHODS +23714 METHODS +23715 RESULTS +23716 CONCLUSIONS +23717 RESULTS +23718 CONCLUSIONS +23719 BACKGROUND +23720 CONCLUSIONS +23721 OBJECTIVE +23722 METHODS +23723 METHODS +23724 METHODS +23725 METHODS +23726 METHODS +23727 METHODS +23728 METHODS +23729 RESULTS +23730 RESULTS +23731 CONCLUSIONS +23732 BACKGROUND +23733 OBJECTIVE +23734 CONCLUSIONS +23735 METHODS +23736 RESULTS +23737 CONCLUSIONS +23738 METHODS +23739 METHODS +23740 RESULTS +23741 RESULTS +23742 RESULTS +23743 CONCLUSIONS +23744 CONCLUSIONS +23745 BACKGROUND +23746 METHODS +23747 METHODS +23748 METHODS +23749 METHODS +23750 METHODS +23751 METHODS +23752 RESULTS +23753 RESULTS +23754 RESULTS +23755 CONCLUSIONS +23756 OBJECTIVE +23757 METHODS +23758 METHODS +23759 RESULTS +23760 RESULTS +23761 RESULTS +23762 RESULTS +23763 OBJECTIVE +23764 BACKGROUND +23765 METHODS +23766 METHODS +23767 RESULTS +23768 RESULTS +23769 RESULTS +23770 CONCLUSIONS +23771 CONCLUSIONS +23772 CONCLUSIONS +23773 OBJECTIVE +23774 METHODS +23775 METHODS +23776 METHODS +23777 METHODS +23778 METHODS +23779 METHODS +23780 RESULTS +23781 RESULTS +23782 RESULTS +23783 CONCLUSIONS +23784 RESULTS +23785 CONCLUSIONS +23786 OBJECTIVE +23787 METHODS +23788 METHODS +23789 METHODS +23790 METHODS +23791 METHODS +23792 METHODS +23793 RESULTS +23794 RESULTS +23795 RESULTS +23796 RESULTS +23797 CONCLUSIONS +23798 BACKGROUND +23799 OBJECTIVE +23800 METHODS +23801 METHODS +23802 METHODS +23803 RESULTS +23804 RESULTS +23805 CONCLUSIONS +23806 CONCLUSIONS +23807 BACKGROUND +23808 OBJECTIVE +23809 METHODS +23810 METHODS +23811 RESULTS +23812 METHODS +23813 METHODS +23814 METHODS +23815 METHODS +23816 METHODS +23817 METHODS +23818 METHODS +23819 METHODS +23820 METHODS +23821 RESULTS +23822 RESULTS +23823 RESULTS +23824 RESULTS +23825 CONCLUSIONS +23826 BACKGROUND +23827 BACKGROUND +23828 BACKGROUND +23829 BACKGROUND +23830 BACKGROUND +23831 OBJECTIVE +23832 METHODS +23833 METHODS +23834 RESULTS +23835 RESULTS +23836 CONCLUSIONS +23837 CONCLUSIONS +23838 OBJECTIVE +23839 METHODS +23840 METHODS +23841 METHODS +23842 METHODS +23843 METHODS +23844 RESULTS +23845 RESULTS +23846 CONCLUSIONS +23847 CONCLUSIONS +23848 OBJECTIVE +23849 OBJECTIVE +23850 METHODS +23851 METHODS +23852 METHODS +23853 METHODS +23854 METHODS +23855 METHODS +23856 RESULTS +23857 RESULTS +23858 RESULTS +23859 CONCLUSIONS +23860 CONCLUSIONS +23861 OBJECTIVE +23862 METHODS +23863 METHODS +23864 METHODS +23865 METHODS +23866 METHODS +23867 RESULTS +23868 RESULTS +23869 RESULTS +23870 RESULTS +23871 RESULTS +23872 RESULTS +23873 CONCLUSIONS +23874 BACKGROUND +23875 BACKGROUND +23876 BACKGROUND +23877 METHODS +23878 METHODS +23879 METHODS +23880 METHODS +23881 RESULTS +23882 RESULTS +23883 RESULTS +23884 RESULTS +23885 RESULTS +23886 RESULTS +23887 CONCLUSIONS +23888 CONCLUSIONS +23889 OBJECTIVE +23890 METHODS +23891 RESULTS +23892 RESULTS +23893 RESULTS +23894 RESULTS +23895 RESULTS +23896 CONCLUSIONS +23897 OBJECTIVE +23898 BACKGROUND +23899 BACKGROUND +23900 METHODS +23901 METHODS +23902 METHODS +23903 METHODS +23904 METHODS +23905 RESULTS +23906 RESULTS +23907 RESULTS +23908 CONCLUSIONS +23909 BACKGROUND +23910 OBJECTIVE +23911 METHODS +23912 METHODS +23913 RESULTS +23914 RESULTS +23915 RESULTS +23916 RESULTS +23917 CONCLUSIONS +23918 CONCLUSIONS +23919 CONCLUSIONS +23920 OBJECTIVE +23921 METHODS +23922 METHODS +23923 METHODS +23924 RESULTS +23925 RESULTS +23926 RESULTS +23927 CONCLUSIONS +23928 CONCLUSIONS +23929 OBJECTIVE +23930 METHODS +23931 METHODS +23932 RESULTS +23933 RESULTS +23934 METHODS +23935 METHODS +23936 METHODS +23937 RESULTS +23938 RESULTS +23939 RESULTS +23940 CONCLUSIONS +23941 OBJECTIVE +23942 METHODS +23943 METHODS +23944 METHODS +23945 METHODS +23946 METHODS +23947 RESULTS +23948 RESULTS +23949 RESULTS +23950 CONCLUSIONS +23951 CONCLUSIONS +23952 CONCLUSIONS +23953 BACKGROUND +23954 BACKGROUND +23955 BACKGROUND +23956 METHODS +23957 METHODS +23958 METHODS +23959 METHODS +23960 METHODS +23961 METHODS +23962 METHODS +23963 METHODS +23964 CONCLUSIONS +23965 CONCLUSIONS +23966 BACKGROUND +23967 OBJECTIVE +23968 METHODS +23969 METHODS +23970 RESULTS +23971 RESULTS +23972 RESULTS +23973 CONCLUSIONS +23974 CONCLUSIONS +23975 CONCLUSIONS +23976 CONCLUSIONS +23977 BACKGROUND +23978 BACKGROUND +23979 OBJECTIVE +23980 METHODS +23981 METHODS +23982 METHODS +23983 METHODS +23984 METHODS +23985 METHODS +23986 METHODS +23987 RESULTS +23988 RESULTS +23989 RESULTS +23990 RESULTS +23991 RESULTS +23992 RESULTS +23993 RESULTS +23994 CONCLUSIONS +23995 OBJECTIVE +23996 METHODS +23997 METHODS +23998 METHODS +23999 METHODS +24000 RESULTS +24001 RESULTS +24002 CONCLUSIONS +24003 BACKGROUND +24004 OBJECTIVE +24005 METHODS +24006 METHODS +24007 METHODS +24008 RESULTS +24009 RESULTS +24010 RESULTS +24011 RESULTS +24012 RESULTS +24013 RESULTS +24014 CONCLUSIONS +24015 OBJECTIVE +24016 METHODS +24017 METHODS +24018 METHODS +24019 METHODS +24020 RESULTS +24021 RESULTS +24022 RESULTS +24023 CONCLUSIONS +24024 RESULTS +24025 OBJECTIVE +24026 METHODS +24027 METHODS +24028 METHODS +24029 METHODS +24030 RESULTS +24031 CONCLUSIONS +24032 OBJECTIVE +24033 METHODS +24034 METHODS +24035 METHODS +24036 METHODS +24037 METHODS +24038 METHODS +24039 METHODS +24040 RESULTS +24041 RESULTS +24042 RESULTS +24043 RESULTS +24044 RESULTS +24045 RESULTS +24046 RESULTS +24047 RESULTS +24048 RESULTS +24049 CONCLUSIONS +24050 CONCLUSIONS +24051 CONCLUSIONS +24052 BACKGROUND +24053 OBJECTIVE +24054 METHODS +24055 METHODS +24056 METHODS +24057 METHODS +24058 METHODS +24059 METHODS +24060 RESULTS +24061 RESULTS +24062 RESULTS +24063 CONCLUSIONS +24064 BACKGROUND +24065 OBJECTIVE +24066 METHODS +24067 METHODS +24068 METHODS +24069 RESULTS +24070 RESULTS +24071 METHODS +24072 RESULTS +24073 RESULTS +24074 CONCLUSIONS +24075 BACKGROUND +24076 BACKGROUND +24077 METHODS +24078 METHODS +24079 METHODS +24080 METHODS +24081 METHODS +24082 RESULTS +24083 RESULTS +24084 RESULTS +24085 RESULTS +24086 RESULTS +24087 CONCLUSIONS +24088 BACKGROUND +24089 OBJECTIVE +24090 METHODS +24091 METHODS +24092 METHODS +24093 RESULTS +24094 RESULTS +24095 RESULTS +24096 RESULTS +24097 RESULTS +24098 RESULTS +24099 CONCLUSIONS +24100 OBJECTIVE +24101 METHODS +24102 METHODS +24103 METHODS +24104 METHODS +24105 METHODS +24106 RESULTS +24107 RESULTS +24108 RESULTS +24109 CONCLUSIONS +24110 OBJECTIVE +24111 METHODS +24112 METHODS +24113 METHODS +24114 RESULTS +24115 RESULTS +24116 RESULTS +24117 CONCLUSIONS +24118 RESULTS +24119 RESULTS +24120 CONCLUSIONS +24121 CONCLUSIONS +24122 CONCLUSIONS +24123 BACKGROUND +24124 OBJECTIVE +24125 METHODS +24126 METHODS +24127 METHODS +24128 METHODS +24129 RESULTS +24130 RESULTS +24131 RESULTS +24132 RESULTS +24133 CONCLUSIONS +24134 CONCLUSIONS +24135 BACKGROUND +24136 BACKGROUND +24137 BACKGROUND +24138 METHODS +24139 METHODS +24140 METHODS +24141 METHODS +24142 METHODS +24143 METHODS +24144 METHODS +24145 RESULTS +24146 RESULTS +24147 RESULTS +24148 RESULTS +24149 CONCLUSIONS +24150 CONCLUSIONS +24151 CONCLUSIONS +24152 BACKGROUND +24153 BACKGROUND +24154 OBJECTIVE +24155 RESULTS +24156 BACKGROUND +24157 BACKGROUND +24158 OBJECTIVE +24159 METHODS +24160 METHODS +24161 METHODS +24162 METHODS +24163 METHODS +24164 METHODS +24165 RESULTS +24166 RESULTS +24167 CONCLUSIONS +24168 RESULTS +24169 RESULTS +24170 RESULTS +24171 CONCLUSIONS +24172 BACKGROUND +24173 OBJECTIVE +24174 METHODS +24175 METHODS +24176 METHODS +24177 METHODS +24178 RESULTS +24179 RESULTS +24180 RESULTS +24181 RESULTS +24182 RESULTS +24183 CONCLUSIONS +24184 BACKGROUND +24185 METHODS +24186 METHODS +24187 METHODS +24188 RESULTS +24189 RESULTS +24190 RESULTS +24191 CONCLUSIONS +24192 OBJECTIVE +24193 METHODS +24194 METHODS +24195 RESULTS +24196 RESULTS +24197 RESULTS +24198 RESULTS +24199 RESULTS +24200 RESULTS +24201 RESULTS +24202 RESULTS +24203 RESULTS +24204 OBJECTIVE +24205 OBJECTIVE +24206 METHODS +24207 METHODS +24208 RESULTS +24209 RESULTS +24210 RESULTS +24211 RESULTS +24212 RESULTS +24213 CONCLUSIONS +24214 OBJECTIVE +24215 BACKGROUND +24216 BACKGROUND +24217 METHODS +24218 RESULTS +24219 METHODS +24220 RESULTS +24221 RESULTS +24222 RESULTS +24223 RESULTS +24224 RESULTS +24225 CONCLUSIONS +24226 CONCLUSIONS +24227 OBJECTIVE +24228 METHODS +24229 METHODS +24230 METHODS +24231 RESULTS +24232 RESULTS +24233 RESULTS +24234 RESULTS +24235 CONCLUSIONS +24236 CONCLUSIONS +24237 BACKGROUND +24238 OBJECTIVE +24239 METHODS +24240 METHODS +24241 METHODS +24242 METHODS +24243 RESULTS +24244 RESULTS +24245 RESULTS +24246 RESULTS +24247 CONCLUSIONS +24248 BACKGROUND +24249 OBJECTIVE +24250 METHODS +24251 METHODS +24252 METHODS +24253 RESULTS +24254 RESULTS +24255 RESULTS +24256 CONCLUSIONS +24257 BACKGROUND +24258 CONCLUSIONS +24259 METHODS +24260 METHODS +24261 METHODS +24262 METHODS +24263 RESULTS +24264 RESULTS +24265 RESULTS +24266 RESULTS +24267 RESULTS +24268 CONCLUSIONS +24269 BACKGROUND +24270 BACKGROUND +24271 METHODS +24272 RESULTS +24273 RESULTS +24274 RESULTS +24275 RESULTS +24276 RESULTS +24277 CONCLUSIONS +24278 BACKGROUND +24279 BACKGROUND +24280 BACKGROUND +24281 BACKGROUND +24282 METHODS +24283 RESULTS +24284 RESULTS +24285 CONCLUSIONS +24286 BACKGROUND +24287 BACKGROUND +24288 METHODS +24289 METHODS +24290 METHODS +24291 METHODS +24292 METHODS +24293 METHODS +24294 CONCLUSIONS +24295 BACKGROUND +24296 BACKGROUND +24297 METHODS +24298 METHODS +24299 METHODS +24300 RESULTS +24301 RESULTS +24302 RESULTS +24303 RESULTS +24304 CONCLUSIONS +24305 OBJECTIVE +24306 METHODS +24307 METHODS +24308 RESULTS +24309 METHODS +24310 RESULTS +24311 RESULTS +24312 RESULTS +24313 RESULTS +24314 RESULTS +24315 RESULTS +24316 RESULTS +24317 RESULTS +24318 CONCLUSIONS +24319 CONCLUSIONS +24320 BACKGROUND +24321 METHODS +24322 RESULTS +24323 METHODS +24324 METHODS +24325 METHODS +24326 METHODS +24327 RESULTS +24328 RESULTS +24329 RESULTS +24330 RESULTS +24331 RESULTS +24332 RESULTS +24333 RESULTS +24334 RESULTS +24335 BACKGROUND +24336 BACKGROUND +24337 METHODS +24338 METHODS +24339 METHODS +24340 RESULTS +24341 RESULTS +24342 RESULTS +24343 RESULTS +24344 RESULTS +24345 RESULTS +24346 RESULTS +24347 CONCLUSIONS +24348 CONCLUSIONS +24349 CONCLUSIONS +24350 OBJECTIVE +24351 METHODS +24352 METHODS +24353 CONCLUSIONS +24354 RESULTS +24355 RESULTS +24356 RESULTS +24357 RESULTS +24358 CONCLUSIONS +24359 CONCLUSIONS +24360 OBJECTIVE +24361 OBJECTIVE +24362 METHODS +24363 RESULTS +24364 RESULTS +24365 RESULTS +24366 RESULTS +24367 RESULTS +24368 CONCLUSIONS +24369 BACKGROUND +24370 BACKGROUND +24371 BACKGROUND +24372 METHODS +24373 METHODS +24374 METHODS +24375 METHODS +24376 RESULTS +24377 RESULTS +24378 RESULTS +24379 RESULTS +24380 CONCLUSIONS +24381 CONCLUSIONS +24382 OBJECTIVE +24383 METHODS +24384 METHODS +24385 METHODS +24386 RESULTS +24387 RESULTS +24388 RESULTS +24389 CONCLUSIONS +24390 BACKGROUND +24391 BACKGROUND +24392 BACKGROUND +24393 CONCLUSIONS +24394 METHODS +24395 METHODS +24396 METHODS +24397 METHODS +24398 METHODS +24399 CONCLUSIONS +24400 CONCLUSIONS +24401 BACKGROUND +24402 METHODS +24403 METHODS +24404 RESULTS +24405 RESULTS +24406 RESULTS +24407 RESULTS +24408 RESULTS +24409 RESULTS +24410 CONCLUSIONS +24411 BACKGROUND +24412 OBJECTIVE +24413 METHODS +24414 RESULTS +24415 METHODS +24416 METHODS +24417 RESULTS +24418 RESULTS +24419 CONCLUSIONS +24420 CONCLUSIONS +24421 BACKGROUND +24422 CONCLUSIONS +24423 METHODS +24424 METHODS +24425 METHODS +24426 METHODS +24427 RESULTS +24428 METHODS +24429 RESULTS +24430 RESULTS +24431 RESULTS +24432 CONCLUSIONS +24433 OBJECTIVE +24434 METHODS +24435 METHODS +24436 METHODS +24437 METHODS +24438 RESULTS +24439 RESULTS +24440 RESULTS +24441 RESULTS +24442 CONCLUSIONS +24443 CONCLUSIONS +24444 BACKGROUND +24445 BACKGROUND +24446 METHODS +24447 METHODS +24448 METHODS +24449 RESULTS +24450 RESULTS +24451 CONCLUSIONS +24452 BACKGROUND +24453 BACKGROUND +24454 OBJECTIVE +24455 METHODS +24456 METHODS +24457 RESULTS +24458 RESULTS +24459 CONCLUSIONS +24460 RESULTS +24461 CONCLUSIONS +24462 OBJECTIVE +24463 METHODS +24464 METHODS +24465 METHODS +24466 METHODS +24467 METHODS +24468 METHODS +24469 RESULTS +24470 RESULTS +24471 RESULTS +24472 RESULTS +24473 CONCLUSIONS +24474 RESULTS +24475 RESULTS +24476 RESULTS +24477 CONCLUSIONS +24478 CONCLUSIONS +24479 CONCLUSIONS +24480 BACKGROUND +24481 METHODS +24482 METHODS +24483 METHODS +24484 METHODS +24485 RESULTS +24486 RESULTS +24487 RESULTS +24488 RESULTS +24489 CONCLUSIONS +24490 BACKGROUND +24491 BACKGROUND +24492 OBJECTIVE +24493 METHODS +24494 METHODS +24495 METHODS +24496 RESULTS +24497 CONCLUSIONS +24498 CONCLUSIONS +24499 OBJECTIVE +24500 METHODS +24501 METHODS +24502 RESULTS +24503 METHODS +24504 METHODS +24505 METHODS +24506 RESULTS +24507 RESULTS +24508 RESULTS +24509 METHODS +24510 METHODS +24511 RESULTS +24512 CONCLUSIONS +24513 BACKGROUND +24514 BACKGROUND +24515 BACKGROUND +24516 METHODS +24517 METHODS +24518 METHODS +24519 RESULTS +24520 RESULTS +24521 RESULTS +24522 METHODS +24523 BACKGROUND +24524 CONCLUSIONS +24525 BACKGROUND +24526 METHODS +24527 METHODS +24528 METHODS +24529 METHODS +24530 RESULTS +24531 RESULTS +24532 RESULTS +24533 RESULTS +24534 RESULTS +24535 RESULTS +24536 CONCLUSIONS +24537 CONCLUSIONS +24538 OBJECTIVE +24539 METHODS +24540 RESULTS +24541 RESULTS +24542 RESULTS +24543 CONCLUSIONS +24544 CONCLUSIONS +24545 CONCLUSIONS +24546 BACKGROUND +24547 BACKGROUND +24548 OBJECTIVE +24549 METHODS +24550 METHODS +24551 RESULTS +24552 RESULTS +24553 RESULTS +24554 RESULTS +24555 CONCLUSIONS +24556 CONCLUSIONS +24557 CONCLUSIONS +24558 CONCLUSIONS +24559 CONCLUSIONS +24560 BACKGROUND +24561 BACKGROUND +24562 BACKGROUND +24563 METHODS +24564 METHODS +24565 METHODS +24566 METHODS +24567 RESULTS +24568 RESULTS +24569 CONCLUSIONS +24570 BACKGROUND +24571 OBJECTIVE +24572 METHODS +24573 METHODS +24574 METHODS +24575 METHODS +24576 RESULTS +24577 RESULTS +24578 CONCLUSIONS +24579 CONCLUSIONS +24580 OBJECTIVE +24581 METHODS +24582 METHODS +24583 METHODS +24584 METHODS +24585 METHODS +24586 METHODS +24587 RESULTS +24588 RESULTS +24589 RESULTS +24590 RESULTS +24591 RESULTS +24592 RESULTS +24593 CONCLUSIONS +24594 RESULTS +24595 OBJECTIVE +24596 RESULTS +24597 METHODS +24598 METHODS +24599 METHODS +24600 METHODS +24601 METHODS +24602 METHODS +24603 RESULTS +24604 RESULTS +24605 RESULTS +24606 RESULTS +24607 RESULTS +24608 RESULTS +24609 CONCLUSIONS +24610 CONCLUSIONS +24611 OBJECTIVE +24612 METHODS +24613 RESULTS +24614 RESULTS +24615 RESULTS +24616 RESULTS +24617 CONCLUSIONS +24618 OBJECTIVE +24619 METHODS +24620 METHODS +24621 METHODS +24622 METHODS +24623 METHODS +24624 RESULTS +24625 METHODS +24626 RESULTS +24627 RESULTS +24628 RESULTS +24629 RESULTS +24630 RESULTS +24631 RESULTS +24632 RESULTS +24633 CONCLUSIONS +24634 RESULTS +24635 RESULTS +24636 CONCLUSIONS +24637 BACKGROUND +24638 OBJECTIVE +24639 METHODS +24640 RESULTS +24641 RESULTS +24642 RESULTS +24643 RESULTS +24644 RESULTS +24645 RESULTS +24646 RESULTS +24647 RESULTS +24648 RESULTS +24649 CONCLUSIONS +24650 CONCLUSIONS +24651 BACKGROUND +24652 OBJECTIVE +24653 METHODS +24654 METHODS +24655 METHODS +24656 METHODS +24657 METHODS +24658 RESULTS +24659 RESULTS +24660 CONCLUSIONS +24661 BACKGROUND +24662 OBJECTIVE +24663 METHODS +24664 METHODS +24665 METHODS +24666 RESULTS +24667 RESULTS +24668 RESULTS +24669 RESULTS +24670 RESULTS +24671 RESULTS +24672 CONCLUSIONS +24673 BACKGROUND +24674 BACKGROUND +24675 METHODS +24676 METHODS +24677 METHODS +24678 RESULTS +24679 RESULTS +24680 RESULTS +24681 RESULTS +24682 RESULTS +24683 METHODS +24684 CONCLUSIONS +24685 CONCLUSIONS +24686 RESULTS +24687 BACKGROUND +24688 BACKGROUND +24689 OBJECTIVE +24690 METHODS +24691 METHODS +24692 METHODS +24693 RESULTS +24694 METHODS +24695 METHODS +24696 METHODS +24697 METHODS +24698 METHODS +24699 RESULTS +24700 RESULTS +24701 RESULTS +24702 RESULTS +24703 CONCLUSIONS +24704 RESULTS +24705 CONCLUSIONS +24706 OBJECTIVE +24707 METHODS +24708 METHODS +24709 METHODS +24710 METHODS +24711 METHODS +24712 METHODS +24713 RESULTS +24714 CONCLUSIONS +24715 CONCLUSIONS +24716 OBJECTIVE +24717 METHODS +24718 METHODS +24719 METHODS +24720 METHODS +24721 RESULTS +24722 RESULTS +24723 RESULTS +24724 RESULTS +24725 CONCLUSIONS +24726 RESULTS +24727 BACKGROUND +24728 BACKGROUND +24729 METHODS +24730 METHODS +24731 METHODS +24732 METHODS +24733 RESULTS +24734 RESULTS +24735 RESULTS +24736 RESULTS +24737 RESULTS +24738 CONCLUSIONS +24739 CONCLUSIONS +24740 BACKGROUND +24741 BACKGROUND +24742 BACKGROUND +24743 OBJECTIVE +24744 METHODS +24745 RESULTS +24746 RESULTS +24747 RESULTS +24748 RESULTS +24749 RESULTS +24750 RESULTS +24751 CONCLUSIONS +24752 BACKGROUND +24753 CONCLUSIONS +24754 OBJECTIVE +24755 METHODS +24756 METHODS +24757 METHODS +24758 METHODS +24759 RESULTS +24760 RESULTS +24761 RESULTS +24762 RESULTS +24763 RESULTS +24764 RESULTS +24765 CONCLUSIONS +24766 OBJECTIVE +24767 METHODS +24768 METHODS +24769 METHODS +24770 METHODS +24771 RESULTS +24772 RESULTS +24773 RESULTS +24774 RESULTS +24775 RESULTS +24776 CONCLUSIONS +24777 CONCLUSIONS +24778 BACKGROUND +24779 OBJECTIVE +24780 METHODS +24781 METHODS +24782 METHODS +24783 METHODS +24784 RESULTS +24785 RESULTS +24786 CONCLUSIONS +24787 CONCLUSIONS +24788 BACKGROUND +24789 BACKGROUND +24790 BACKGROUND +24791 OBJECTIVE +24792 CONCLUSIONS +24793 METHODS +24794 METHODS +24795 METHODS +24796 METHODS +24797 METHODS +24798 METHODS +24799 METHODS +24800 METHODS +24801 CONCLUSIONS +24802 CONCLUSIONS +24803 CONCLUSIONS +24804 BACKGROUND +24805 OBJECTIVE +24806 METHODS +24807 METHODS +24808 METHODS +24809 METHODS +24810 METHODS +24811 METHODS +24812 METHODS +24813 RESULTS +24814 RESULTS +24815 RESULTS +24816 RESULTS +24817 CONCLUSIONS +24818 CONCLUSIONS +24819 BACKGROUND +24820 OBJECTIVE +24821 METHODS +24822 METHODS +24823 METHODS +24824 BACKGROUND +24825 RESULTS +24826 RESULTS +24827 RESULTS +24828 CONCLUSIONS +24829 RESULTS +24830 RESULTS +24831 CONCLUSIONS +24832 OBJECTIVE +24833 METHODS +24834 METHODS +24835 METHODS +24836 METHODS +24837 METHODS +24838 RESULTS +24839 RESULTS +24840 RESULTS +24841 RESULTS +24842 CONCLUSIONS +24843 CONCLUSIONS +24844 CONCLUSIONS +24845 OBJECTIVE +24846 METHODS +24847 METHODS +24848 METHODS +24849 RESULTS +24850 RESULTS +24851 RESULTS +24852 RESULTS +24853 CONCLUSIONS +24854 RESULTS +24855 CONCLUSIONS +24856 BACKGROUND +24857 BACKGROUND +24858 CONCLUSIONS +24859 METHODS +24860 METHODS +24861 RESULTS +24862 RESULTS +24863 RESULTS +24864 RESULTS +24865 CONCLUSIONS +24866 CONCLUSIONS +24867 CONCLUSIONS +24868 OBJECTIVE +24869 METHODS +24870 METHODS +24871 METHODS +24872 METHODS +24873 METHODS +24874 METHODS +24875 METHODS +24876 METHODS +24877 METHODS +24878 RESULTS +24879 RESULTS +24880 RESULTS +24881 RESULTS +24882 RESULTS +24883 CONCLUSIONS +24884 CONCLUSIONS +24885 BACKGROUND +24886 BACKGROUND +24887 OBJECTIVE +24888 METHODS +24889 METHODS +24890 RESULTS +24891 CONCLUSIONS +24892 RESULTS +24893 RESULTS +24894 RESULTS +24895 RESULTS +24896 CONCLUSIONS +24897 BACKGROUND +24898 BACKGROUND +24899 OBJECTIVE +24900 METHODS +24901 RESULTS +24902 METHODS +24903 RESULTS +24904 RESULTS +24905 RESULTS +24906 CONCLUSIONS +24907 OBJECTIVE +24908 METHODS +24909 RESULTS +24910 RESULTS +24911 RESULTS +24912 RESULTS +24913 RESULTS +24914 RESULTS +24915 RESULTS +24916 RESULTS +24917 BACKGROUND +24918 OBJECTIVE +24919 METHODS +24920 METHODS +24921 RESULTS +24922 RESULTS +24923 RESULTS +24924 RESULTS +24925 CONCLUSIONS +24926 CONCLUSIONS +24927 BACKGROUND +24928 OBJECTIVE +24929 METHODS +24930 METHODS +24931 METHODS +24932 RESULTS +24933 RESULTS +24934 RESULTS +24935 RESULTS +24936 RESULTS +24937 CONCLUSIONS +24938 CONCLUSIONS +24939 CONCLUSIONS +24940 OBJECTIVE +24941 METHODS +24942 METHODS +24943 METHODS +24944 METHODS +24945 RESULTS +24946 RESULTS +24947 RESULTS +24948 RESULTS +24949 OBJECTIVE +24950 METHODS +24951 METHODS +24952 RESULTS +24953 RESULTS +24954 RESULTS +24955 CONCLUSIONS +24956 BACKGROUND +24957 BACKGROUND +24958 OBJECTIVE +24959 METHODS +24960 METHODS +24961 METHODS +24962 METHODS +24963 METHODS +24964 METHODS +24965 RESULTS +24966 RESULTS +24967 RESULTS +24968 RESULTS +24969 RESULTS +24970 CONCLUSIONS +24971 BACKGROUND +24972 OBJECTIVE +24973 METHODS +24974 METHODS +24975 METHODS +24976 CONCLUSIONS +24977 RESULTS +24978 RESULTS +24979 RESULTS +24980 RESULTS +24981 RESULTS +24982 CONCLUSIONS +24983 CONCLUSIONS +24984 BACKGROUND +24985 BACKGROUND +24986 METHODS +24987 METHODS +24988 METHODS +24989 METHODS +24990 METHODS +24991 METHODS +24992 METHODS +24993 RESULTS +24994 RESULTS +24995 RESULTS +24996 RESULTS +24997 RESULTS +24998 CONCLUSIONS +24999 BACKGROUND +25000 BACKGROUND +25001 METHODS +25002 METHODS +25003 METHODS +25004 METHODS +25005 METHODS +25006 METHODS +25007 METHODS +25008 METHODS +25009 RESULTS +25010 RESULTS +25011 RESULTS +25012 RESULTS +25013 RESULTS +25014 CONCLUSIONS +25015 CONCLUSIONS +25016 OBJECTIVE +25017 BACKGROUND +25018 CONCLUSIONS +25019 METHODS +25020 METHODS +25021 RESULTS +25022 RESULTS +25023 RESULTS +25024 CONCLUSIONS +25025 OBJECTIVE +25026 BACKGROUND +25027 BACKGROUND +25028 METHODS +25029 METHODS +25030 RESULTS +25031 RESULTS +25032 RESULTS +25033 RESULTS +25034 CONCLUSIONS +25035 BACKGROUND +25036 BACKGROUND +25037 OBJECTIVE +25038 METHODS +25039 METHODS +25040 METHODS +25041 RESULTS +25042 RESULTS +25043 BACKGROUND +25044 CONCLUSIONS +25045 BACKGROUND +25046 BACKGROUND +25047 METHODS +25048 OBJECTIVE +25049 METHODS +25050 RESULTS +25051 RESULTS +25052 RESULTS +25053 RESULTS +25054 RESULTS +25055 BACKGROUND +25056 CONCLUSIONS +25057 BACKGROUND +25058 METHODS +25059 METHODS +25060 METHODS +25061 METHODS +25062 RESULTS +25063 RESULTS +25064 CONCLUSIONS +25065 RESULTS +25066 BACKGROUND +25067 CONCLUSIONS +25068 BACKGROUND +25069 OBJECTIVE +25070 BACKGROUND +25071 METHODS +25072 METHODS +25073 METHODS +25074 RESULTS +25075 RESULTS +25076 CONCLUSIONS +25077 CONCLUSIONS +25078 CONCLUSIONS +25079 OBJECTIVE +25080 METHODS +25081 METHODS +25082 METHODS +25083 METHODS +25084 RESULTS +25085 RESULTS +25086 RESULTS +25087 RESULTS +25088 CONCLUSIONS +25089 BACKGROUND +25090 BACKGROUND +25091 BACKGROUND +25092 BACKGROUND +25093 OBJECTIVE +25094 METHODS +25095 METHODS +25096 METHODS +25097 METHODS +25098 METHODS +25099 METHODS +25100 METHODS +25101 BACKGROUND +25102 BACKGROUND +25103 BACKGROUND +25104 BACKGROUND +25105 OBJECTIVE +25106 METHODS +25107 METHODS +25108 METHODS +25109 RESULTS +25110 RESULTS +25111 RESULTS +25112 METHODS +25113 CONCLUSIONS +25114 BACKGROUND +25115 OBJECTIVE +25116 METHODS +25117 METHODS +25118 RESULTS +25119 RESULTS +25120 RESULTS +25121 RESULTS +25122 RESULTS +25123 CONCLUSIONS +25124 OBJECTIVE +25125 METHODS +25126 METHODS +25127 METHODS +25128 METHODS +25129 METHODS +25130 METHODS +25131 METHODS +25132 METHODS +25133 RESULTS +25134 RESULTS +25135 CONCLUSIONS +25136 BACKGROUND +25137 OBJECTIVE +25138 METHODS +25139 METHODS +25140 METHODS +25141 METHODS +25142 METHODS +25143 METHODS +25144 RESULTS +25145 RESULTS +25146 RESULTS +25147 CONCLUSIONS +25148 RESULTS +25149 OBJECTIVE +25150 BACKGROUND +25151 METHODS +25152 METHODS +25153 METHODS +25154 METHODS +25155 METHODS +25156 METHODS +25157 METHODS +25158 RESULTS +25159 CONCLUSIONS +25160 RESULTS +25161 RESULTS +25162 RESULTS +25163 RESULTS +25164 RESULTS +25165 CONCLUSIONS +25166 CONCLUSIONS +25167 OBJECTIVE +25168 OBJECTIVE +25169 METHODS +25170 METHODS +25171 METHODS +25172 METHODS +25173 RESULTS +25174 RESULTS +25175 RESULTS +25176 RESULTS +25177 RESULTS +25178 RESULTS +25179 RESULTS +25180 RESULTS +25181 CONCLUSIONS +25182 RESULTS +25183 RESULTS +25184 OBJECTIVE +25185 METHODS +25186 METHODS +25187 METHODS +25188 RESULTS +25189 RESULTS +25190 RESULTS +25191 CONCLUSIONS +25192 RESULTS +25193 BACKGROUND +25194 METHODS +25195 METHODS +25196 METHODS +25197 METHODS +25198 RESULTS +25199 RESULTS +25200 RESULTS +25201 CONCLUSIONS +25202 OBJECTIVE +25203 METHODS +25204 METHODS +25205 METHODS +25206 METHODS +25207 METHODS +25208 METHODS +25209 METHODS +25210 RESULTS +25211 RESULTS +25212 CONCLUSIONS +25213 BACKGROUND +25214 CONCLUSIONS +25215 CONCLUSIONS +25216 OBJECTIVE +25217 OBJECTIVE +25218 OBJECTIVE +25219 METHODS +25220 METHODS +25221 METHODS +25222 RESULTS +25223 RESULTS +25224 RESULTS +25225 RESULTS +25226 RESULTS +25227 CONCLUSIONS +25228 BACKGROUND +25229 BACKGROUND +25230 BACKGROUND +25231 METHODS +25232 METHODS +25233 METHODS +25234 METHODS +25235 METHODS +25236 METHODS +25237 RESULTS +25238 RESULTS +25239 RESULTS +25240 RESULTS +25241 RESULTS +25242 CONCLUSIONS +25243 CONCLUSIONS +25244 OBJECTIVE +25245 METHODS +25246 METHODS +25247 METHODS +25248 METHODS +25249 METHODS +25250 METHODS +25251 METHODS +25252 METHODS +25253 RESULTS +25254 RESULTS +25255 RESULTS +25256 CONCLUSIONS +25257 BACKGROUND +25258 BACKGROUND +25259 METHODS +25260 METHODS +25261 METHODS +25262 RESULTS +25263 RESULTS +25264 RESULTS +25265 CONCLUSIONS +25266 BACKGROUND +25267 CONCLUSIONS +25268 METHODS +25269 METHODS +25270 RESULTS +25271 RESULTS +25272 RESULTS +25273 CONCLUSIONS +25274 CONCLUSIONS +25275 BACKGROUND +25276 BACKGROUND +25277 BACKGROUND +25278 METHODS +25279 METHODS +25280 METHODS +25281 METHODS +25282 METHODS +25283 RESULTS +25284 RESULTS +25285 RESULTS +25286 CONCLUSIONS +25287 CONCLUSIONS +25288 BACKGROUND +25289 BACKGROUND +25290 METHODS +25291 METHODS +25292 RESULTS +25293 RESULTS +25294 RESULTS +25295 CONCLUSIONS +25296 CONCLUSIONS +25297 OBJECTIVE +25298 OBJECTIVE +25299 METHODS +25300 METHODS +25301 METHODS +25302 METHODS +25303 RESULTS +25304 RESULTS +25305 RESULTS +25306 RESULTS +25307 CONCLUSIONS +25308 CONCLUSIONS +25309 BACKGROUND +25310 BACKGROUND +25311 METHODS +25312 RESULTS +25313 RESULTS +25314 RESULTS +25315 RESULTS +25316 CONCLUSIONS +25317 CONCLUSIONS +25318 CONCLUSIONS +25319 BACKGROUND +25320 BACKGROUND +25321 BACKGROUND +25322 BACKGROUND +25323 BACKGROUND +25324 BACKGROUND +25325 METHODS +25326 METHODS +25327 METHODS +25328 METHODS +25329 METHODS +25330 METHODS +25331 CONCLUSIONS +25332 CONCLUSIONS +25333 CONCLUSIONS +25334 BACKGROUND +25335 BACKGROUND +25336 BACKGROUND +25337 BACKGROUND +25338 METHODS +25339 METHODS +25340 METHODS +25341 METHODS +25342 RESULTS +25343 RESULTS +25344 RESULTS +25345 RESULTS +25346 RESULTS +25347 CONCLUSIONS +25348 BACKGROUND +25349 OBJECTIVE +25350 METHODS +25351 METHODS +25352 METHODS +25353 METHODS +25354 RESULTS +25355 RESULTS +25356 RESULTS +25357 CONCLUSIONS +25358 CONCLUSIONS +25359 BACKGROUND +25360 BACKGROUND +25361 METHODS +25362 METHODS +25363 METHODS +25364 METHODS +25365 METHODS +25366 METHODS +25367 METHODS +25368 RESULTS +25369 RESULTS +25370 RESULTS +25371 RESULTS +25372 RESULTS +25373 CONCLUSIONS +25374 BACKGROUND +25375 METHODS +25376 OBJECTIVE +25377 BACKGROUND +25378 OBJECTIVE +25379 METHODS +25380 METHODS +25381 METHODS +25382 METHODS +25383 METHODS +25384 METHODS +25385 RESULTS +25386 RESULTS +25387 RESULTS +25388 RESULTS +25389 RESULTS +25390 RESULTS +25391 CONCLUSIONS +25392 OBJECTIVE +25393 BACKGROUND +25394 BACKGROUND +25395 BACKGROUND +25396 OBJECTIVE +25397 METHODS +25398 METHODS +25399 METHODS +25400 RESULTS +25401 RESULTS +25402 RESULTS +25403 RESULTS +25404 RESULTS +25405 RESULTS +25406 CONCLUSIONS +25407 CONCLUSIONS +25408 OBJECTIVE +25409 METHODS +25410 METHODS +25411 METHODS +25412 RESULTS +25413 RESULTS +25414 RESULTS +25415 RESULTS +25416 RESULTS +25417 CONCLUSIONS +25418 BACKGROUND +25419 OBJECTIVE +25420 METHODS +25421 METHODS +25422 METHODS +25423 METHODS +25424 RESULTS +25425 RESULTS +25426 CONCLUSIONS +25427 RESULTS +25428 CONCLUSIONS +25429 OBJECTIVE +25430 METHODS +25431 METHODS +25432 RESULTS +25433 RESULTS +25434 CONCLUSIONS +25435 RESULTS +25436 CONCLUSIONS +25437 OBJECTIVE +25438 METHODS +25439 METHODS +25440 METHODS +25441 RESULTS +25442 RESULTS +25443 RESULTS +25444 RESULTS +25445 RESULTS +25446 RESULTS +25447 RESULTS +25448 RESULTS +25449 RESULTS +25450 CONCLUSIONS +25451 CONCLUSIONS +25452 OBJECTIVE +25453 METHODS +25454 METHODS +25455 METHODS +25456 METHODS +25457 METHODS +25458 METHODS +25459 RESULTS +25460 RESULTS +25461 RESULTS +25462 RESULTS +25463 CONCLUSIONS +25464 CONCLUSIONS +25465 OBJECTIVE +25466 METHODS +25467 METHODS +25468 METHODS +25469 METHODS +25470 RESULTS +25471 METHODS +25472 METHODS +25473 RESULTS +25474 RESULTS +25475 RESULTS +25476 RESULTS +25477 RESULTS +25478 RESULTS +25479 METHODS +25480 RESULTS +25481 RESULTS +25482 RESULTS +25483 CONCLUSIONS +25484 CONCLUSIONS +25485 CONCLUSIONS +25486 METHODS +25487 OBJECTIVE +25488 BACKGROUND +25489 METHODS +25490 METHODS +25491 METHODS +25492 RESULTS +25493 RESULTS +25494 RESULTS +25495 RESULTS +25496 RESULTS +25497 CONCLUSIONS +25498 CONCLUSIONS +25499 BACKGROUND +25500 BACKGROUND +25501 METHODS +25502 METHODS +25503 METHODS +25504 METHODS +25505 METHODS +25506 METHODS +25507 METHODS +25508 RESULTS +25509 RESULTS +25510 RESULTS +25511 CONCLUSIONS +25512 BACKGROUND +25513 OBJECTIVE +25514 METHODS +25515 METHODS +25516 RESULTS +25517 RESULTS +25518 RESULTS +25519 RESULTS +25520 RESULTS +25521 CONCLUSIONS +25522 OBJECTIVE +25523 METHODS +25524 METHODS +25525 METHODS +25526 METHODS +25527 METHODS +25528 METHODS +25529 METHODS +25530 RESULTS +25531 RESULTS +25532 OBJECTIVE +25533 METHODS +25534 METHODS +25535 METHODS +25536 METHODS +25537 METHODS +25538 METHODS +25539 RESULTS +25540 RESULTS +25541 CONCLUSIONS +25542 METHODS +25543 OBJECTIVE +25544 METHODS +25545 METHODS +25546 METHODS +25547 METHODS +25548 METHODS +25549 RESULTS +25550 RESULTS +25551 RESULTS +25552 RESULTS +25553 RESULTS +25554 RESULTS +25555 BACKGROUND +25556 CONCLUSIONS +25557 CONCLUSIONS +25558 BACKGROUND +25559 OBJECTIVE +25560 METHODS +25561 METHODS +25562 METHODS +25563 RESULTS +25564 RESULTS +25565 RESULTS +25566 RESULTS +25567 CONCLUSIONS +25568 CONCLUSIONS +25569 BACKGROUND +25570 BACKGROUND +25571 BACKGROUND +25572 METHODS +25573 METHODS +25574 RESULTS +25575 RESULTS +25576 RESULTS +25577 RESULTS +25578 RESULTS +25579 RESULTS +25580 RESULTS +25581 CONCLUSIONS +25582 CONCLUSIONS +25583 OBJECTIVE +25584 METHODS +25585 METHODS +25586 METHODS +25587 METHODS +25588 RESULTS +25589 RESULTS +25590 RESULTS +25591 CONCLUSIONS +25592 BACKGROUND +25593 BACKGROUND +25594 OBJECTIVE +25595 METHODS +25596 METHODS +25597 METHODS +25598 METHODS +25599 RESULTS +25600 RESULTS +25601 RESULTS +25602 CONCLUSIONS +25603 BACKGROUND +25604 OBJECTIVE +25605 OBJECTIVE +25606 METHODS +25607 METHODS +25608 METHODS +25609 METHODS +25610 METHODS +25611 RESULTS +25612 RESULTS +25613 CONCLUSIONS +25614 OBJECTIVE +25615 METHODS +25616 RESULTS +25617 RESULTS +25618 CONCLUSIONS +25619 OBJECTIVE +25620 METHODS +25621 METHODS +25622 METHODS +25623 METHODS +25624 METHODS +25625 METHODS +25626 RESULTS +25627 RESULTS +25628 RESULTS +25629 RESULTS +25630 CONCLUSIONS +25631 CONCLUSIONS +25632 BACKGROUND +25633 BACKGROUND +25634 BACKGROUND +25635 METHODS +25636 METHODS +25637 METHODS +25638 METHODS +25639 METHODS +25640 RESULTS +25641 RESULTS +25642 RESULTS +25643 RESULTS +25644 RESULTS +25645 RESULTS +25646 RESULTS +25647 RESULTS +25648 CONCLUSIONS +25649 RESULTS +25650 CONCLUSIONS +25651 BACKGROUND +25652 BACKGROUND +25653 METHODS +25654 METHODS +25655 METHODS +25656 RESULTS +25657 RESULTS +25658 RESULTS +25659 RESULTS +25660 CONCLUSIONS +25661 CONCLUSIONS +25662 CONCLUSIONS +25663 OBJECTIVE +25664 OBJECTIVE +25665 METHODS +25666 METHODS +25667 METHODS +25668 METHODS +25669 RESULTS +25670 RESULTS +25671 RESULTS +25672 RESULTS +25673 RESULTS +25674 CONCLUSIONS +25675 CONCLUSIONS +25676 BACKGROUND +25677 BACKGROUND +25678 BACKGROUND +25679 METHODS +25680 METHODS +25681 METHODS +25682 METHODS +25683 METHODS +25684 METHODS +25685 METHODS +25686 CONCLUSIONS +25687 CONCLUSIONS +25688 BACKGROUND +25689 OBJECTIVE +25690 METHODS +25691 METHODS +25692 METHODS +25693 OBJECTIVE +25694 RESULTS +25695 RESULTS +25696 RESULTS +25697 RESULTS +25698 RESULTS +25699 RESULTS +25700 RESULTS +25701 CONCLUSIONS +25702 BACKGROUND +25703 OBJECTIVE +25704 METHODS +25705 METHODS +25706 METHODS +25707 METHODS +25708 METHODS +25709 RESULTS +25710 RESULTS +25711 RESULTS +25712 RESULTS +25713 RESULTS +25714 RESULTS +25715 RESULTS +25716 RESULTS +25717 RESULTS +25718 CONCLUSIONS +25719 BACKGROUND +25720 BACKGROUND +25721 OBJECTIVE +25722 METHODS +25723 METHODS +25724 METHODS +25725 RESULTS +25726 RESULTS +25727 CONCLUSIONS +25728 CONCLUSIONS +25729 OBJECTIVE +25730 METHODS +25731 METHODS +25732 METHODS +25733 METHODS +25734 RESULTS +25735 RESULTS +25736 RESULTS +25737 RESULTS +25738 RESULTS +25739 RESULTS +25740 RESULTS +25741 CONCLUSIONS +25742 RESULTS +25743 CONCLUSIONS +25744 BACKGROUND +25745 BACKGROUND +25746 BACKGROUND +25747 BACKGROUND +25748 BACKGROUND +25749 METHODS +25750 METHODS +25751 RESULTS +25752 RESULTS +25753 RESULTS +25754 CONCLUSIONS +25755 OBJECTIVE +25756 METHODS +25757 METHODS +25758 RESULTS +25759 CONCLUSIONS +25760 CONCLUSIONS +25761 OBJECTIVE +25762 BACKGROUND +25763 OBJECTIVE +25764 METHODS +25765 METHODS +25766 RESULTS +25767 METHODS +25768 METHODS +25769 RESULTS +25770 RESULTS +25771 RESULTS +25772 CONCLUSIONS +25773 RESULTS +25774 RESULTS +25775 RESULTS +25776 RESULTS +25777 RESULTS +25778 CONCLUSIONS +25779 BACKGROUND +25780 OBJECTIVE +25781 METHODS +25782 METHODS +25783 METHODS +25784 METHODS +25785 METHODS +25786 METHODS +25787 METHODS +25788 METHODS +25789 RESULTS +25790 RESULTS +25791 RESULTS +25792 RESULTS +25793 RESULTS +25794 CONCLUSIONS +25795 BACKGROUND +25796 BACKGROUND +25797 OBJECTIVE +25798 METHODS +25799 METHODS +25800 METHODS +25801 RESULTS +25802 RESULTS +25803 RESULTS +25804 METHODS +25805 RESULTS +25806 CONCLUSIONS +25807 OBJECTIVE +25808 METHODS +25809 METHODS +25810 RESULTS +25811 CONCLUSIONS +25812 METHODS +25813 CONCLUSIONS +25814 RESULTS +25815 OBJECTIVE +25816 METHODS +25817 METHODS +25818 METHODS +25819 METHODS +25820 RESULTS +25821 RESULTS +25822 RESULTS +25823 CONCLUSIONS +25824 CONCLUSIONS +25825 BACKGROUND +25826 OBJECTIVE +25827 METHODS +25828 METHODS +25829 METHODS +25830 RESULTS +25831 RESULTS +25832 RESULTS +25833 RESULTS +25834 CONCLUSIONS +25835 OBJECTIVE +25836 METHODS +25837 METHODS +25838 METHODS +25839 METHODS +25840 METHODS +25841 METHODS +25842 METHODS +25843 RESULTS +25844 RESULTS +25845 RESULTS +25846 CONCLUSIONS +25847 CONCLUSIONS +25848 OBJECTIVE +25849 METHODS +25850 METHODS +25851 RESULTS +25852 RESULTS +25853 RESULTS +25854 RESULTS +25855 RESULTS +25856 RESULTS +25857 RESULTS +25858 RESULTS +25859 CONCLUSIONS +25860 RESULTS +25861 OBJECTIVE +25862 METHODS +25863 METHODS +25864 METHODS +25865 METHODS +25866 METHODS +25867 METHODS +25868 RESULTS +25869 RESULTS +25870 CONCLUSIONS +25871 OBJECTIVE +25872 METHODS +25873 METHODS +25874 METHODS +25875 RESULTS +25876 RESULTS +25877 RESULTS +25878 RESULTS +25879 RESULTS +25880 RESULTS +25881 RESULTS +25882 CONCLUSIONS +25883 BACKGROUND +25884 BACKGROUND +25885 BACKGROUND +25886 METHODS +25887 METHODS +25888 METHODS +25889 METHODS +25890 METHODS +25891 METHODS +25892 METHODS +25893 METHODS +25894 BACKGROUND +25895 CONCLUSIONS +25896 BACKGROUND +25897 OBJECTIVE +25898 METHODS +25899 METHODS +25900 METHODS +25901 METHODS +25902 METHODS +25903 RESULTS +25904 RESULTS +25905 RESULTS +25906 RESULTS +25907 RESULTS +25908 CONCLUSIONS +25909 BACKGROUND +25910 BACKGROUND +25911 METHODS +25912 METHODS +25913 METHODS +25914 METHODS +25915 RESULTS +25916 RESULTS +25917 RESULTS +25918 RESULTS +25919 CONCLUSIONS +25920 OBJECTIVE +25921 METHODS +25922 METHODS +25923 METHODS +25924 RESULTS +25925 RESULTS +25926 RESULTS +25927 METHODS +25928 RESULTS +25929 METHODS +25930 RESULTS +25931 RESULTS +25932 CONCLUSIONS +25933 RESULTS +25934 CONCLUSIONS +25935 OBJECTIVE +25936 METHODS +25937 METHODS +25938 METHODS +25939 METHODS +25940 METHODS +25941 RESULTS +25942 RESULTS +25943 RESULTS +25944 CONCLUSIONS +25945 CONCLUSIONS +25946 CONCLUSIONS +25947 OBJECTIVE +25948 METHODS +25949 METHODS +25950 METHODS +25951 RESULTS +25952 RESULTS +25953 RESULTS +25954 RESULTS +25955 RESULTS +25956 RESULTS +25957 RESULTS +25958 RESULTS +25959 CONCLUSIONS +25960 OBJECTIVE +25961 METHODS +25962 METHODS +25963 METHODS +25964 METHODS +25965 RESULTS +25966 RESULTS +25967 RESULTS +25968 RESULTS +25969 RESULTS +25970 CONCLUSIONS +25971 CONCLUSIONS +25972 OBJECTIVE +25973 METHODS +25974 RESULTS +25975 RESULTS +25976 RESULTS +25977 RESULTS +25978 CONCLUSIONS +25979 CONCLUSIONS +25980 OBJECTIVE +25981 METHODS +25982 METHODS +25983 METHODS +25984 METHODS +25985 METHODS +25986 RESULTS +25987 RESULTS +25988 CONCLUSIONS +25989 OBJECTIVE +25990 METHODS +25991 METHODS +25992 METHODS +25993 METHODS +25994 RESULTS +25995 RESULTS +25996 RESULTS +25997 RESULTS +25998 CONCLUSIONS +25999 BACKGROUND +26000 BACKGROUND +26001 BACKGROUND +26002 METHODS +26003 METHODS +26004 RESULTS +26005 RESULTS +26006 RESULTS +26007 RESULTS +26008 RESULTS +26009 CONCLUSIONS +26010 RESULTS +26011 OBJECTIVE +26012 CONCLUSIONS +26013 CONCLUSIONS +26014 CONCLUSIONS +26015 METHODS +26016 METHODS +26017 RESULTS +26018 METHODS +26019 METHODS +26020 METHODS +26021 METHODS +26022 RESULTS +26023 RESULTS +26024 RESULTS +26025 RESULTS +26026 RESULTS +26027 RESULTS +26028 RESULTS +26029 RESULTS +26030 RESULTS +26031 RESULTS +26032 RESULTS +26033 CONCLUSIONS +26034 RESULTS +26035 CONCLUSIONS +26036 CONCLUSIONS +26037 RESULTS +26038 CONCLUSIONS +26039 CONCLUSIONS +26040 BACKGROUND +26041 BACKGROUND +26042 METHODS +26043 OBJECTIVE +26044 METHODS +26045 METHODS +26046 METHODS +26047 CONCLUSIONS +26048 METHODS +26049 METHODS +26050 METHODS +26051 CONCLUSIONS +26052 BACKGROUND +26053 BACKGROUND +26054 OBJECTIVE +26055 BACKGROUND +26056 METHODS +26057 METHODS +26058 METHODS +26059 RESULTS +26060 RESULTS +26061 RESULTS +26062 CONCLUSIONS +26063 OBJECTIVE +26064 METHODS +26065 METHODS +26066 METHODS +26067 RESULTS +26068 RESULTS +26069 RESULTS +26070 CONCLUSIONS +26071 CONCLUSIONS +26072 CONCLUSIONS +26073 OBJECTIVE +26074 METHODS +26075 METHODS +26076 METHODS +26077 METHODS +26078 METHODS +26079 RESULTS +26080 RESULTS +26081 CONCLUSIONS +26082 BACKGROUND +26083 OBJECTIVE +26084 METHODS +26085 METHODS +26086 METHODS +26087 METHODS +26088 METHODS +26089 RESULTS +26090 RESULTS +26091 RESULTS +26092 RESULTS +26093 CONCLUSIONS +26094 BACKGROUND +26095 BACKGROUND +26096 METHODS +26097 METHODS +26098 RESULTS +26099 RESULTS +26100 RESULTS +26101 RESULTS +26102 CONCLUSIONS +26103 BACKGROUND +26104 BACKGROUND +26105 OBJECTIVE +26106 METHODS +26107 METHODS +26108 METHODS +26109 RESULTS +26110 RESULTS +26111 RESULTS +26112 RESULTS +26113 CONCLUSIONS +26114 OBJECTIVE +26115 METHODS +26116 METHODS +26117 METHODS +26118 METHODS +26119 RESULTS +26120 RESULTS +26121 RESULTS +26122 RESULTS +26123 RESULTS +26124 CONCLUSIONS +26125 BACKGROUND +26126 BACKGROUND +26127 BACKGROUND +26128 METHODS +26129 METHODS +26130 METHODS +26131 RESULTS +26132 METHODS +26133 RESULTS +26134 RESULTS +26135 RESULTS +26136 BACKGROUND +26137 CONCLUSIONS +26138 CONCLUSIONS +26139 BACKGROUND +26140 BACKGROUND +26141 BACKGROUND +26142 OBJECTIVE +26143 METHODS +26144 METHODS +26145 METHODS +26146 METHODS +26147 METHODS +26148 RESULTS +26149 RESULTS +26150 RESULTS +26151 CONCLUSIONS +26152 CONCLUSIONS +26153 CONCLUSIONS +26154 BACKGROUND +26155 METHODS +26156 METHODS +26157 RESULTS +26158 RESULTS +26159 RESULTS +26160 RESULTS +26161 RESULTS +26162 RESULTS +26163 RESULTS +26164 CONCLUSIONS +26165 OBJECTIVE +26166 METHODS +26167 METHODS +26168 METHODS +26169 METHODS +26170 RESULTS +26171 RESULTS +26172 RESULTS +26173 RESULTS +26174 CONCLUSIONS +26175 RESULTS +26176 BACKGROUND +26177 CONCLUSIONS +26178 BACKGROUND +26179 OBJECTIVE +26180 METHODS +26181 METHODS +26182 METHODS +26183 METHODS +26184 METHODS +26185 METHODS +26186 METHODS +26187 RESULTS +26188 RESULTS +26189 RESULTS +26190 RESULTS +26191 RESULTS +26192 CONCLUSIONS +26193 OBJECTIVE +26194 METHODS +26195 METHODS +26196 METHODS +26197 METHODS +26198 METHODS +26199 RESULTS +26200 RESULTS +26201 RESULTS +26202 RESULTS +26203 CONCLUSIONS +26204 CONCLUSIONS +26205 OBJECTIVE +26206 OBJECTIVE +26207 METHODS +26208 METHODS +26209 METHODS +26210 METHODS +26211 RESULTS +26212 RESULTS +26213 RESULTS +26214 RESULTS +26215 RESULTS +26216 RESULTS +26217 CONCLUSIONS +26218 BACKGROUND +26219 BACKGROUND +26220 OBJECTIVE +26221 METHODS +26222 METHODS +26223 RESULTS +26224 RESULTS +26225 CONCLUSIONS +26226 OBJECTIVE +26227 METHODS +26228 METHODS +26229 METHODS +26230 RESULTS +26231 RESULTS +26232 RESULTS +26233 RESULTS +26234 RESULTS +26235 RESULTS +26236 OBJECTIVE +26237 BACKGROUND +26238 METHODS +26239 METHODS +26240 OBJECTIVE +26241 METHODS +26242 METHODS +26243 METHODS +26244 RESULTS +26245 RESULTS +26246 RESULTS +26247 CONCLUSIONS +26248 BACKGROUND +26249 OBJECTIVE +26250 METHODS +26251 METHODS +26252 METHODS +26253 METHODS +26254 RESULTS +26255 RESULTS +26256 RESULTS +26257 CONCLUSIONS +26258 BACKGROUND +26259 BACKGROUND +26260 METHODS +26261 RESULTS +26262 RESULTS +26263 METHODS +26264 RESULTS +26265 CONCLUSIONS +26266 CONCLUSIONS +26267 OBJECTIVE +26268 METHODS +26269 METHODS +26270 METHODS +26271 METHODS +26272 METHODS +26273 RESULTS +26274 RESULTS +26275 RESULTS +26276 RESULTS +26277 RESULTS +26278 RESULTS +26279 CONCLUSIONS +26280 CONCLUSIONS +26281 OBJECTIVE +26282 METHODS +26283 METHODS +26284 RESULTS +26285 RESULTS +26286 RESULTS +26287 CONCLUSIONS +26288 OBJECTIVE +26289 METHODS +26290 METHODS +26291 METHODS +26292 METHODS +26293 RESULTS +26294 RESULTS +26295 RESULTS +26296 RESULTS +26297 RESULTS +26298 CONCLUSIONS +26299 CONCLUSIONS +26300 CONCLUSIONS +26301 CONCLUSIONS +26302 OBJECTIVE +26303 METHODS +26304 METHODS +26305 METHODS +26306 RESULTS +26307 RESULTS +26308 RESULTS +26309 RESULTS +26310 CONCLUSIONS +26311 OBJECTIVE +26312 BACKGROUND +26313 METHODS +26314 METHODS +26315 METHODS +26316 RESULTS +26317 RESULTS +26318 RESULTS +26319 RESULTS +26320 CONCLUSIONS +26321 BACKGROUND +26322 BACKGROUND +26323 METHODS +26324 METHODS +26325 RESULTS +26326 RESULTS +26327 RESULTS +26328 RESULTS +26329 CONCLUSIONS +26330 CONCLUSIONS +26331 OBJECTIVE +26332 METHODS +26333 METHODS +26334 METHODS +26335 METHODS +26336 METHODS +26337 RESULTS +26338 RESULTS +26339 RESULTS +26340 RESULTS +26341 CONCLUSIONS +26342 OBJECTIVE +26343 METHODS +26344 METHODS +26345 METHODS +26346 METHODS +26347 METHODS +26348 METHODS +26349 RESULTS +26350 RESULTS +26351 RESULTS +26352 RESULTS +26353 RESULTS +26354 CONCLUSIONS +26355 RESULTS +26356 CONCLUSIONS +26357 BACKGROUND +26358 METHODS +26359 BACKGROUND +26360 OBJECTIVE +26361 METHODS +26362 METHODS +26363 METHODS +26364 RESULTS +26365 METHODS +26366 METHODS +26367 RESULTS +26368 RESULTS +26369 RESULTS +26370 RESULTS +26371 RESULTS +26372 RESULTS +26373 RESULTS +26374 RESULTS +26375 CONCLUSIONS +26376 OBJECTIVE +26377 METHODS +26378 METHODS +26379 METHODS +26380 METHODS +26381 RESULTS +26382 METHODS +26383 METHODS +26384 METHODS +26385 RESULTS +26386 RESULTS +26387 RESULTS +26388 RESULTS +26389 RESULTS +26390 RESULTS +26391 RESULTS +26392 CONCLUSIONS +26393 BACKGROUND +26394 OBJECTIVE +26395 METHODS +26396 METHODS +26397 METHODS +26398 RESULTS +26399 RESULTS +26400 RESULTS +26401 RESULTS +26402 RESULTS +26403 RESULTS +26404 BACKGROUND +26405 OBJECTIVE +26406 METHODS +26407 METHODS +26408 RESULTS +26409 RESULTS +26410 RESULTS +26411 RESULTS +26412 RESULTS +26413 RESULTS +26414 CONCLUSIONS +26415 BACKGROUND +26416 OBJECTIVE +26417 BACKGROUND +26418 METHODS +26419 METHODS +26420 METHODS +26421 RESULTS +26422 RESULTS +26423 RESULTS +26424 RESULTS +26425 CONCLUSIONS +26426 RESULTS +26427 RESULTS +26428 OBJECTIVE +26429 BACKGROUND +26430 METHODS +26431 METHODS +26432 RESULTS +26433 RESULTS +26434 RESULTS +26435 RESULTS +26436 CONCLUSIONS +26437 CONCLUSIONS +26438 BACKGROUND +26439 BACKGROUND +26440 OBJECTIVE +26441 METHODS +26442 METHODS +26443 METHODS +26444 METHODS +26445 RESULTS +26446 METHODS +26447 METHODS +26448 METHODS +26449 METHODS +26450 METHODS +26451 RESULTS +26452 RESULTS +26453 METHODS +26454 RESULTS +26455 RESULTS +26456 METHODS +26457 RESULTS +26458 CONCLUSIONS +26459 RESULTS +26460 OBJECTIVE +26461 METHODS +26462 METHODS +26463 METHODS +26464 RESULTS +26465 RESULTS +26466 RESULTS +26467 CONCLUSIONS +26468 CONCLUSIONS +26469 CONCLUSIONS +26470 BACKGROUND +26471 BACKGROUND +26472 OBJECTIVE +26473 METHODS +26474 METHODS +26475 RESULTS +26476 RESULTS +26477 RESULTS +26478 CONCLUSIONS +26479 CONCLUSIONS +26480 OBJECTIVE +26481 METHODS +26482 METHODS +26483 METHODS +26484 METHODS +26485 METHODS +26486 RESULTS +26487 RESULTS +26488 CONCLUSIONS +26489 BACKGROUND +26490 BACKGROUND +26491 OBJECTIVE +26492 METHODS +26493 METHODS +26494 METHODS +26495 METHODS +26496 METHODS +26497 METHODS +26498 METHODS +26499 METHODS +26500 RESULTS +26501 RESULTS +26502 RESULTS +26503 RESULTS +26504 RESULTS +26505 CONCLUSIONS +26506 CONCLUSIONS +26507 CONCLUSIONS +26508 CONCLUSIONS +26509 CONCLUSIONS +26510 RESULTS +26511 CONCLUSIONS +26512 BACKGROUND +26513 OBJECTIVE +26514 METHODS +26515 METHODS +26516 METHODS +26517 RESULTS +26518 RESULTS +26519 RESULTS +26520 RESULTS +26521 CONCLUSIONS +26522 BACKGROUND +26523 BACKGROUND +26524 BACKGROUND +26525 METHODS +26526 METHODS +26527 METHODS +26528 RESULTS +26529 RESULTS +26530 RESULTS +26531 RESULTS +26532 RESULTS +26533 RESULTS +26534 RESULTS +26535 RESULTS +26536 CONCLUSIONS +26537 CONCLUSIONS +26538 CONCLUSIONS +26539 BACKGROUND +26540 BACKGROUND +26541 BACKGROUND +26542 OBJECTIVE +26543 METHODS +26544 RESULTS +26545 METHODS +26546 METHODS +26547 RESULTS +26548 RESULTS +26549 RESULTS +26550 RESULTS +26551 CONCLUSIONS +26552 BACKGROUND +26553 BACKGROUND +26554 METHODS +26555 METHODS +26556 METHODS +26557 METHODS +26558 RESULTS +26559 RESULTS +26560 RESULTS +26561 CONCLUSIONS +26562 CONCLUSIONS +26563 CONCLUSIONS +26564 OBJECTIVE +26565 METHODS +26566 METHODS +26567 METHODS +26568 METHODS +26569 RESULTS +26570 RESULTS +26571 RESULTS +26572 RESULTS +26573 CONCLUSIONS +26574 BACKGROUND +26575 CONCLUSIONS +26576 OBJECTIVE +26577 METHODS +26578 METHODS +26579 METHODS +26580 METHODS +26581 METHODS +26582 METHODS +26583 RESULTS +26584 RESULTS +26585 RESULTS +26586 RESULTS +26587 RESULTS +26588 CONCLUSIONS +26589 BACKGROUND +26590 BACKGROUND +26591 METHODS +26592 METHODS +26593 RESULTS +26594 RESULTS +26595 RESULTS +26596 RESULTS +26597 RESULTS +26598 RESULTS +26599 CONCLUSIONS +26600 CONCLUSIONS +26601 BACKGROUND +26602 BACKGROUND +26603 RESULTS +26604 BACKGROUND +26605 METHODS +26606 RESULTS +26607 RESULTS +26608 RESULTS +26609 RESULTS +26610 RESULTS +26611 RESULTS +26612 RESULTS +26613 BACKGROUND +26614 OBJECTIVE +26615 METHODS +26616 METHODS +26617 METHODS +26618 RESULTS +26619 RESULTS +26620 RESULTS +26621 RESULTS +26622 RESULTS +26623 CONCLUSIONS +26624 CONCLUSIONS +26625 BACKGROUND +26626 OBJECTIVE +26627 METHODS +26628 METHODS +26629 METHODS +26630 RESULTS +26631 RESULTS +26632 RESULTS +26633 RESULTS +26634 RESULTS +26635 RESULTS +26636 CONCLUSIONS +26637 CONCLUSIONS +26638 CONCLUSIONS +26639 BACKGROUND +26640 METHODS +26641 METHODS +26642 RESULTS +26643 RESULTS +26644 RESULTS +26645 CONCLUSIONS +26646 CONCLUSIONS +26647 OBJECTIVE +26648 METHODS +26649 METHODS +26650 METHODS +26651 METHODS +26652 METHODS +26653 RESULTS +26654 RESULTS +26655 RESULTS +26656 RESULTS +26657 RESULTS +26658 RESULTS +26659 RESULTS +26660 CONCLUSIONS +26661 CONCLUSIONS +26662 OBJECTIVE +26663 METHODS +26664 METHODS +26665 METHODS +26666 RESULTS +26667 RESULTS +26668 CONCLUSIONS +26669 BACKGROUND +26670 BACKGROUND +26671 OBJECTIVE +26672 METHODS +26673 METHODS +26674 METHODS +26675 METHODS +26676 METHODS +26677 RESULTS +26678 RESULTS +26679 RESULTS +26680 RESULTS +26681 RESULTS +26682 CONCLUSIONS +26683 OBJECTIVE +26684 METHODS +26685 METHODS +26686 METHODS +26687 RESULTS +26688 RESULTS +26689 RESULTS +26690 RESULTS +26691 CONCLUSIONS +26692 OBJECTIVE +26693 METHODS +26694 METHODS +26695 METHODS +26696 RESULTS +26697 METHODS +26698 METHODS +26699 METHODS +26700 METHODS +26701 RESULTS +26702 RESULTS +26703 RESULTS +26704 CONCLUSIONS +26705 BACKGROUND +26706 BACKGROUND +26707 BACKGROUND +26708 BACKGROUND +26709 BACKGROUND +26710 OBJECTIVE +26711 METHODS +26712 METHODS +26713 RESULTS +26714 RESULTS +26715 RESULTS +26716 RESULTS +26717 CONCLUSIONS +26718 CONCLUSIONS +26719 BACKGROUND +26720 BACKGROUND +26721 METHODS +26722 METHODS +26723 RESULTS +26724 RESULTS +26725 RESULTS +26726 BACKGROUND +26727 RESULTS +26728 CONCLUSIONS +26729 CONCLUSIONS +26730 OBJECTIVE +26731 METHODS +26732 METHODS +26733 METHODS +26734 METHODS +26735 METHODS +26736 METHODS +26737 RESULTS +26738 RESULTS +26739 RESULTS +26740 RESULTS +26741 CONCLUSIONS +26742 CONCLUSIONS +26743 BACKGROUND +26744 OBJECTIVE +26745 METHODS +26746 METHODS +26747 METHODS +26748 METHODS +26749 RESULTS +26750 RESULTS +26751 RESULTS +26752 CONCLUSIONS +26753 CONCLUSIONS +26754 CONCLUSIONS +26755 OBJECTIVE +26756 METHODS +26757 METHODS +26758 METHODS +26759 METHODS +26760 METHODS +26761 RESULTS +26762 CONCLUSIONS +26763 BACKGROUND +26764 BACKGROUND +26765 OBJECTIVE +26766 METHODS +26767 METHODS +26768 METHODS +26769 METHODS +26770 RESULTS +26771 RESULTS +26772 RESULTS +26773 CONCLUSIONS +26774 BACKGROUND +26775 BACKGROUND +26776 BACKGROUND +26777 METHODS +26778 METHODS +26779 METHODS +26780 RESULTS +26781 RESULTS +26782 RESULTS +26783 CONCLUSIONS +26784 BACKGROUND +26785 BACKGROUND +26786 OBJECTIVE +26787 METHODS +26788 METHODS +26789 METHODS +26790 RESULTS +26791 METHODS +26792 METHODS +26793 RESULTS +26794 CONCLUSIONS +26795 OBJECTIVE +26796 METHODS +26797 METHODS +26798 RESULTS +26799 RESULTS +26800 RESULTS +26801 RESULTS +26802 RESULTS +26803 CONCLUSIONS +26804 CONCLUSIONS +26805 RESULTS +26806 OBJECTIVE +26807 METHODS +26808 METHODS +26809 RESULTS +26810 RESULTS +26811 RESULTS +26812 RESULTS +26813 RESULTS +26814 RESULTS +26815 RESULTS +26816 CONCLUSIONS +26817 CONCLUSIONS +26818 BACKGROUND +26819 OBJECTIVE +26820 METHODS +26821 METHODS +26822 METHODS +26823 RESULTS +26824 RESULTS +26825 CONCLUSIONS +26826 METHODS +26827 OBJECTIVE +26828 METHODS +26829 METHODS +26830 METHODS +26831 METHODS +26832 METHODS +26833 METHODS +26834 METHODS +26835 RESULTS +26836 RESULTS +26837 RESULTS +26838 CONCLUSIONS +26839 BACKGROUND +26840 CONCLUSIONS +26841 BACKGROUND +26842 BACKGROUND +26843 OBJECTIVE +26844 METHODS +26845 METHODS +26846 METHODS +26847 RESULTS +26848 RESULTS +26849 CONCLUSIONS +26850 CONCLUSIONS +26851 OBJECTIVE +26852 METHODS +26853 METHODS +26854 METHODS +26855 RESULTS +26856 METHODS +26857 METHODS +26858 METHODS +26859 RESULTS +26860 RESULTS +26861 CONCLUSIONS +26862 CONCLUSIONS +26863 OBJECTIVE +26864 BACKGROUND +26865 METHODS +26866 RESULTS +26867 RESULTS +26868 RESULTS +26869 CONCLUSIONS +26870 OBJECTIVE +26871 METHODS +26872 METHODS +26873 RESULTS +26874 RESULTS +26875 RESULTS +26876 RESULTS +26877 RESULTS +26878 CONCLUSIONS +26879 RESULTS +26880 BACKGROUND +26881 OBJECTIVE +26882 METHODS +26883 METHODS +26884 RESULTS +26885 RESULTS +26886 CONCLUSIONS +26887 OBJECTIVE +26888 BACKGROUND +26889 CONCLUSIONS +26890 OBJECTIVE +26891 RESULTS +26892 METHODS +26893 RESULTS +26894 RESULTS +26895 RESULTS +26896 RESULTS +26897 RESULTS +26898 CONCLUSIONS +26899 BACKGROUND +26900 BACKGROUND +26901 BACKGROUND +26902 METHODS +26903 METHODS +26904 METHODS +26905 OBJECTIVE +26906 METHODS +26907 METHODS +26908 METHODS +26909 RESULTS +26910 RESULTS +26911 RESULTS +26912 RESULTS +26913 RESULTS +26914 RESULTS +26915 CONCLUSIONS +26916 CONCLUSIONS +26917 BACKGROUND +26918 BACKGROUND +26919 BACKGROUND +26920 BACKGROUND +26921 BACKGROUND +26922 OBJECTIVE +26923 METHODS +26924 METHODS +26925 METHODS +26926 METHODS +26927 METHODS +26928 RESULTS +26929 RESULTS +26930 RESULTS +26931 RESULTS +26932 RESULTS +26933 RESULTS +26934 CONCLUSIONS +26935 OBJECTIVE +26936 METHODS +26937 METHODS +26938 METHODS +26939 METHODS +26940 METHODS +26941 METHODS +26942 RESULTS +26943 RESULTS +26944 RESULTS +26945 CONCLUSIONS +26946 CONCLUSIONS +26947 CONCLUSIONS +26948 BACKGROUND +26949 BACKGROUND +26950 OBJECTIVE +26951 METHODS +26952 METHODS +26953 METHODS +26954 METHODS +26955 RESULTS +26956 RESULTS +26957 RESULTS +26958 RESULTS +26959 RESULTS +26960 CONCLUSIONS +26961 BACKGROUND +26962 CONCLUSIONS +26963 BACKGROUND +26964 METHODS +26965 METHODS +26966 METHODS +26967 RESULTS +26968 RESULTS +26969 RESULTS +26970 RESULTS +26971 RESULTS +26972 CONCLUSIONS +26973 CONCLUSIONS +26974 OBJECTIVE +26975 METHODS +26976 METHODS +26977 RESULTS +26978 RESULTS +26979 CONCLUSIONS +26980 BACKGROUND +26981 BACKGROUND +26982 METHODS +26983 METHODS +26984 METHODS +26985 METHODS +26986 METHODS +26987 RESULTS +26988 RESULTS +26989 RESULTS +26990 RESULTS +26991 RESULTS +26992 RESULTS +26993 RESULTS +26994 CONCLUSIONS +26995 BACKGROUND +26996 BACKGROUND +26997 BACKGROUND +26998 BACKGROUND +26999 BACKGROUND +27000 METHODS +27001 METHODS +27002 METHODS +27003 METHODS +27004 METHODS +27005 METHODS +27006 RESULTS +27007 RESULTS +27008 RESULTS +27009 CONCLUSIONS +27010 RESULTS +27011 RESULTS +27012 BACKGROUND +27013 METHODS +27014 METHODS +27015 METHODS +27016 METHODS +27017 METHODS +27018 METHODS +27019 RESULTS +27020 RESULTS +27021 RESULTS +27022 RESULTS +27023 RESULTS +27024 CONCLUSIONS +27025 CONCLUSIONS +27026 OBJECTIVE +27027 METHODS +27028 METHODS +27029 METHODS +27030 RESULTS +27031 RESULTS +27032 RESULTS +27033 RESULTS +27034 CONCLUSIONS +27035 BACKGROUND +27036 METHODS +27037 BACKGROUND +27038 METHODS +27039 METHODS +27040 RESULTS +27041 RESULTS +27042 RESULTS +27043 CONCLUSIONS +27044 CONCLUSIONS +27045 OBJECTIVE +27046 METHODS +27047 METHODS +27048 METHODS +27049 RESULTS +27050 RESULTS +27051 RESULTS +27052 RESULTS +27053 RESULTS +27054 RESULTS +27055 CONCLUSIONS +27056 CONCLUSIONS +27057 CONCLUSIONS +27058 CONCLUSIONS +27059 BACKGROUND +27060 METHODS +27061 RESULTS +27062 METHODS +27063 METHODS +27064 RESULTS +27065 RESULTS +27066 RESULTS +27067 RESULTS +27068 CONCLUSIONS +27069 CONCLUSIONS +27070 CONCLUSIONS +27071 BACKGROUND +27072 BACKGROUND +27073 METHODS +27074 METHODS +27075 METHODS +27076 METHODS +27077 METHODS +27078 METHODS +27079 RESULTS +27080 RESULTS +27081 RESULTS +27082 RESULTS +27083 CONCLUSIONS +27084 OBJECTIVE +27085 METHODS +27086 METHODS +27087 METHODS +27088 METHODS +27089 RESULTS +27090 RESULTS +27091 RESULTS +27092 CONCLUSIONS +27093 CONCLUSIONS +27094 OBJECTIVE +27095 METHODS +27096 METHODS +27097 RESULTS +27098 RESULTS +27099 RESULTS +27100 RESULTS +27101 CONCLUSIONS +27102 METHODS +27103 CONCLUSIONS +27104 BACKGROUND +27105 OBJECTIVE +27106 METHODS +27107 METHODS +27108 METHODS +27109 METHODS +27110 RESULTS +27111 RESULTS +27112 CONCLUSIONS +27113 CONCLUSIONS +27114 OBJECTIVE +27115 METHODS +27116 METHODS +27117 METHODS +27118 METHODS +27119 METHODS +27120 RESULTS +27121 RESULTS +27122 CONCLUSIONS +27123 CONCLUSIONS +27124 BACKGROUND +27125 CONCLUSIONS +27126 OBJECTIVE +27127 METHODS +27128 METHODS +27129 RESULTS +27130 METHODS +27131 METHODS +27132 RESULTS +27133 RESULTS +27134 RESULTS +27135 RESULTS +27136 RESULTS +27137 CONCLUSIONS +27138 OBJECTIVE +27139 OBJECTIVE +27140 BACKGROUND +27141 BACKGROUND +27142 CONCLUSIONS +27143 OBJECTIVE +27144 METHODS +27145 METHODS +27146 METHODS +27147 METHODS +27148 METHODS +27149 METHODS +27150 RESULTS +27151 RESULTS +27152 RESULTS +27153 RESULTS +27154 RESULTS +27155 CONCLUSIONS +27156 CONCLUSIONS +27157 CONCLUSIONS +27158 BACKGROUND +27159 BACKGROUND +27160 OBJECTIVE +27161 METHODS +27162 METHODS +27163 METHODS +27164 METHODS +27165 METHODS +27166 METHODS +27167 METHODS +27168 RESULTS +27169 RESULTS +27170 RESULTS +27171 RESULTS +27172 CONCLUSIONS +27173 OBJECTIVE +27174 METHODS +27175 METHODS +27176 RESULTS +27177 RESULTS +27178 RESULTS +27179 RESULTS +27180 RESULTS +27181 RESULTS +27182 RESULTS +27183 RESULTS +27184 OBJECTIVE +27185 METHODS +27186 METHODS +27187 RESULTS +27188 RESULTS +27189 RESULTS +27190 RESULTS +27191 CONCLUSIONS +27192 OBJECTIVE +27193 BACKGROUND +27194 METHODS +27195 METHODS +27196 METHODS +27197 METHODS +27198 METHODS +27199 METHODS +27200 METHODS +27201 RESULTS +27202 RESULTS +27203 RESULTS +27204 RESULTS +27205 RESULTS +27206 CONCLUSIONS +27207 CONCLUSIONS +27208 CONCLUSIONS +27209 BACKGROUND +27210 METHODS +27211 METHODS +27212 METHODS +27213 RESULTS +27214 RESULTS +27215 RESULTS +27216 RESULTS +27217 RESULTS +27218 CONCLUSIONS +27219 BACKGROUND +27220 BACKGROUND +27221 RESULTS +27222 RESULTS +27223 RESULTS +27224 RESULTS +27225 RESULTS +27226 RESULTS +27227 RESULTS +27228 RESULTS +27229 CONCLUSIONS +27230 CONCLUSIONS +27231 CONCLUSIONS +27232 BACKGROUND +27233 BACKGROUND +27234 METHODS +27235 METHODS +27236 METHODS +27237 METHODS +27238 METHODS +27239 METHODS +27240 RESULTS +27241 RESULTS +27242 RESULTS +27243 CONCLUSIONS +27244 CONCLUSIONS +27245 BACKGROUND +27246 BACKGROUND +27247 METHODS +27248 RESULTS +27249 RESULTS +27250 RESULTS +27251 RESULTS +27252 RESULTS +27253 CONCLUSIONS +27254 OBJECTIVE +27255 METHODS +27256 METHODS +27257 METHODS +27258 RESULTS +27259 RESULTS +27260 RESULTS +27261 CONCLUSIONS +27262 CONCLUSIONS +27263 CONCLUSIONS +27264 BACKGROUND +27265 METHODS +27266 METHODS +27267 METHODS +27268 RESULTS +27269 RESULTS +27270 RESULTS +27271 RESULTS +27272 RESULTS +27273 RESULTS +27274 RESULTS +27275 BACKGROUND +27276 CONCLUSIONS +27277 BACKGROUND +27278 BACKGROUND +27279 METHODS +27280 METHODS +27281 METHODS +27282 METHODS +27283 METHODS +27284 RESULTS +27285 RESULTS +27286 RESULTS +27287 RESULTS +27288 RESULTS +27289 CONCLUSIONS +27290 METHODS +27291 OBJECTIVE +27292 METHODS +27293 METHODS +27294 METHODS +27295 RESULTS +27296 RESULTS +27297 RESULTS +27298 RESULTS +27299 RESULTS +27300 CONCLUSIONS +27301 OBJECTIVE +27302 METHODS +27303 METHODS +27304 METHODS +27305 METHODS +27306 RESULTS +27307 RESULTS +27308 RESULTS +27309 RESULTS +27310 RESULTS +27311 CONCLUSIONS +27312 CONCLUSIONS +27313 OBJECTIVE +27314 METHODS +27315 METHODS +27316 METHODS +27317 RESULTS +27318 RESULTS +27319 RESULTS +27320 RESULTS +27321 CONCLUSIONS +27322 CONCLUSIONS +27323 OBJECTIVE +27324 METHODS +27325 METHODS +27326 METHODS +27327 RESULTS +27328 METHODS +27329 METHODS +27330 METHODS +27331 METHODS +27332 RESULTS +27333 RESULTS +27334 RESULTS +27335 RESULTS +27336 CONCLUSIONS +27337 CONCLUSIONS +27338 OBJECTIVE +27339 OBJECTIVE +27340 METHODS +27341 RESULTS +27342 METHODS +27343 RESULTS +27344 RESULTS +27345 RESULTS +27346 RESULTS +27347 CONCLUSIONS +27348 CONCLUSIONS +27349 CONCLUSIONS +27350 BACKGROUND +27351 BACKGROUND +27352 METHODS +27353 METHODS +27354 METHODS +27355 RESULTS +27356 CONCLUSIONS +27357 BACKGROUND +27358 BACKGROUND +27359 METHODS +27360 METHODS +27361 METHODS +27362 METHODS +27363 METHODS +27364 METHODS +27365 RESULTS +27366 RESULTS +27367 RESULTS +27368 RESULTS +27369 CONCLUSIONS +27370 BACKGROUND +27371 OBJECTIVE +27372 METHODS +27373 METHODS +27374 METHODS +27375 RESULTS +27376 RESULTS +27377 RESULTS +27378 RESULTS +27379 RESULTS +27380 CONCLUSIONS +27381 OBJECTIVE +27382 METHODS +27383 METHODS +27384 METHODS +27385 METHODS +27386 METHODS +27387 METHODS +27388 RESULTS +27389 METHODS +27390 RESULTS +27391 RESULTS +27392 CONCLUSIONS +27393 CONCLUSIONS +27394 BACKGROUND +27395 OBJECTIVE +27396 METHODS +27397 METHODS +27398 METHODS +27399 METHODS +27400 METHODS +27401 RESULTS +27402 RESULTS +27403 RESULTS +27404 RESULTS +27405 BACKGROUND +27406 CONCLUSIONS +27407 BACKGROUND +27408 OBJECTIVE +27409 METHODS +27410 METHODS +27411 METHODS +27412 RESULTS +27413 RESULTS +27414 CONCLUSIONS +27415 OBJECTIVE +27416 METHODS +27417 METHODS +27418 METHODS +27419 METHODS +27420 METHODS +27421 RESULTS +27422 RESULTS +27423 RESULTS +27424 RESULTS +27425 RESULTS +27426 CONCLUSIONS +27427 BACKGROUND +27428 CONCLUSIONS +27429 BACKGROUND +27430 BACKGROUND +27431 BACKGROUND +27432 BACKGROUND +27433 BACKGROUND +27434 BACKGROUND +27435 METHODS +27436 METHODS +27437 OBJECTIVE +27438 METHODS +27439 METHODS +27440 METHODS +27441 METHODS +27442 RESULTS +27443 CONCLUSIONS +27444 METHODS +27445 CONCLUSIONS +27446 CONCLUSIONS +27447 CONCLUSIONS +27448 BACKGROUND +27449 BACKGROUND +27450 BACKGROUND +27451 METHODS +27452 RESULTS +27453 RESULTS +27454 CONCLUSIONS +27455 BACKGROUND +27456 BACKGROUND +27457 BACKGROUND +27458 BACKGROUND +27459 METHODS +27460 CONCLUSIONS +27461 METHODS +27462 METHODS +27463 METHODS +27464 METHODS +27465 BACKGROUND +27466 BACKGROUND +27467 BACKGROUND +27468 OBJECTIVE +27469 METHODS +27470 METHODS +27471 METHODS +27472 METHODS +27473 METHODS +27474 RESULTS +27475 RESULTS +27476 RESULTS +27477 RESULTS +27478 RESULTS +27479 RESULTS +27480 CONCLUSIONS +27481 CONCLUSIONS +27482 CONCLUSIONS +27483 BACKGROUND +27484 BACKGROUND +27485 BACKGROUND +27486 METHODS +27487 METHODS +27488 METHODS +27489 METHODS +27490 RESULTS +27491 RESULTS +27492 RESULTS +27493 RESULTS +27494 CONCLUSIONS +27495 CONCLUSIONS +27496 CONCLUSIONS +27497 OBJECTIVE +27498 METHODS +27499 METHODS +27500 METHODS +27501 RESULTS +27502 RESULTS +27503 RESULTS +27504 CONCLUSIONS +27505 CONCLUSIONS +27506 RESULTS +27507 OBJECTIVE +27508 METHODS +27509 METHODS +27510 METHODS +27511 METHODS +27512 METHODS +27513 METHODS +27514 METHODS +27515 METHODS +27516 RESULTS +27517 CONCLUSIONS +27518 CONCLUSIONS +27519 CONCLUSIONS +27520 OBJECTIVE +27521 METHODS +27522 METHODS +27523 METHODS +27524 METHODS +27525 RESULTS +27526 RESULTS +27527 RESULTS +27528 RESULTS +27529 CONCLUSIONS +27530 BACKGROUND +27531 OBJECTIVE +27532 METHODS +27533 METHODS +27534 METHODS +27535 RESULTS +27536 RESULTS +27537 RESULTS +27538 CONCLUSIONS +27539 BACKGROUND +27540 BACKGROUND +27541 BACKGROUND +27542 OBJECTIVE +27543 METHODS +27544 METHODS +27545 RESULTS +27546 RESULTS +27547 CONCLUSIONS +27548 CONCLUSIONS +27549 OBJECTIVE +27550 METHODS +27551 METHODS +27552 METHODS +27553 METHODS +27554 METHODS +27555 RESULTS +27556 RESULTS +27557 RESULTS +27558 RESULTS +27559 CONCLUSIONS +27560 CONCLUSIONS +27561 BACKGROUND +27562 BACKGROUND +27563 OBJECTIVE +27564 METHODS +27565 METHODS +27566 METHODS +27567 RESULTS +27568 RESULTS +27569 RESULTS +27570 CONCLUSIONS +27571 BACKGROUND +27572 OBJECTIVE +27573 METHODS +27574 METHODS +27575 METHODS +27576 METHODS +27577 METHODS +27578 METHODS +27579 METHODS +27580 RESULTS +27581 RESULTS +27582 CONCLUSIONS +27583 CONCLUSIONS +27584 OBJECTIVE +27585 OBJECTIVE +27586 OBJECTIVE +27587 BACKGROUND +27588 METHODS +27589 METHODS +27590 RESULTS +27591 RESULTS +27592 RESULTS +27593 RESULTS +27594 CONCLUSIONS +27595 CONCLUSIONS +27596 CONCLUSIONS +27597 BACKGROUND +27598 METHODS +27599 METHODS +27600 RESULTS +27601 RESULTS +27602 RESULTS +27603 RESULTS +27604 RESULTS +27605 RESULTS +27606 CONCLUSIONS +27607 CONCLUSIONS +27608 OBJECTIVE +27609 BACKGROUND +27610 BACKGROUND +27611 METHODS +27612 METHODS +27613 METHODS +27614 RESULTS +27615 RESULTS +27616 RESULTS +27617 CONCLUSIONS +27618 BACKGROUND +27619 BACKGROUND +27620 BACKGROUND +27621 OBJECTIVE +27622 METHODS +27623 METHODS +27624 CONCLUSIONS +27625 RESULTS +27626 CONCLUSIONS +27627 CONCLUSIONS +27628 OBJECTIVE +27629 METHODS +27630 METHODS +27631 METHODS +27632 METHODS +27633 METHODS +27634 METHODS +27635 METHODS +27636 METHODS +27637 RESULTS +27638 RESULTS +27639 RESULTS +27640 CONCLUSIONS +27641 OBJECTIVE +27642 METHODS +27643 METHODS +27644 METHODS +27645 METHODS +27646 RESULTS +27647 RESULTS +27648 RESULTS +27649 RESULTS +27650 BACKGROUND +27651 OBJECTIVE +27652 METHODS +27653 METHODS +27654 METHODS +27655 METHODS +27656 RESULTS +27657 RESULTS +27658 RESULTS +27659 RESULTS +27660 RESULTS +27661 RESULTS +27662 BACKGROUND +27663 METHODS +27664 METHODS +27665 METHODS +27666 RESULTS +27667 RESULTS +27668 RESULTS +27669 CONCLUSIONS +27670 CONCLUSIONS +27671 OBJECTIVE +27672 METHODS +27673 METHODS +27674 METHODS +27675 METHODS +27676 METHODS +27677 METHODS +27678 RESULTS +27679 RESULTS +27680 RESULTS +27681 RESULTS +27682 CONCLUSIONS +27683 OBJECTIVE +27684 METHODS +27685 METHODS +27686 METHODS +27687 METHODS +27688 METHODS +27689 RESULTS +27690 RESULTS +27691 RESULTS +27692 RESULTS +27693 RESULTS +27694 RESULTS +27695 BACKGROUND +27696 BACKGROUND +27697 OBJECTIVE +27698 METHODS +27699 METHODS +27700 METHODS +27701 METHODS +27702 METHODS +27703 METHODS +27704 METHODS +27705 METHODS +27706 METHODS +27707 METHODS +27708 RESULTS +27709 CONCLUSIONS +27710 RESULTS +27711 RESULTS +27712 CONCLUSIONS +27713 CONCLUSIONS +27714 BACKGROUND +27715 BACKGROUND +27716 BACKGROUND +27717 METHODS +27718 METHODS +27719 RESULTS +27720 RESULTS +27721 CONCLUSIONS +27722 CONCLUSIONS +27723 OBJECTIVE +27724 METHODS +27725 METHODS +27726 METHODS +27727 METHODS +27728 METHODS +27729 METHODS +27730 METHODS +27731 RESULTS +27732 RESULTS +27733 RESULTS +27734 RESULTS +27735 RESULTS +27736 CONCLUSIONS +27737 CONCLUSIONS +27738 CONCLUSIONS +27739 BACKGROUND +27740 OBJECTIVE +27741 METHODS +27742 METHODS +27743 METHODS +27744 METHODS +27745 RESULTS +27746 RESULTS +27747 RESULTS +27748 CONCLUSIONS +27749 CONCLUSIONS +27750 BACKGROUND +27751 OBJECTIVE +27752 METHODS +27753 METHODS +27754 METHODS +27755 METHODS +27756 METHODS +27757 METHODS +27758 RESULTS +27759 CONCLUSIONS +27760 BACKGROUND +27761 BACKGROUND +27762 BACKGROUND +27763 OBJECTIVE +27764 METHODS +27765 RESULTS +27766 RESULTS +27767 CONCLUSIONS +27768 OBJECTIVE +27769 METHODS +27770 METHODS +27771 METHODS +27772 METHODS +27773 METHODS +27774 METHODS +27775 METHODS +27776 RESULTS +27777 RESULTS +27778 RESULTS +27779 CONCLUSIONS +27780 BACKGROUND +27781 BACKGROUND +27782 BACKGROUND +27783 BACKGROUND +27784 METHODS +27785 METHODS +27786 METHODS +27787 METHODS +27788 CONCLUSIONS +27789 RESULTS +27790 RESULTS +27791 RESULTS +27792 RESULTS +27793 RESULTS +27794 BACKGROUND +27795 BACKGROUND +27796 OBJECTIVE +27797 OBJECTIVE +27798 METHODS +27799 METHODS +27800 METHODS +27801 METHODS +27802 METHODS +27803 RESULTS +27804 RESULTS +27805 CONCLUSIONS +27806 RESULTS +27807 CONCLUSIONS +27808 OBJECTIVE +27809 METHODS +27810 METHODS +27811 METHODS +27812 METHODS +27813 METHODS +27814 CONCLUSIONS +27815 RESULTS +27816 RESULTS +27817 RESULTS +27818 CONCLUSIONS +27819 OBJECTIVE +27820 METHODS +27821 METHODS +27822 METHODS +27823 RESULTS +27824 RESULTS +27825 RESULTS +27826 RESULTS +27827 RESULTS +27828 RESULTS +27829 CONCLUSIONS +27830 METHODS +27831 OBJECTIVE +27832 METHODS +27833 METHODS +27834 RESULTS +27835 RESULTS +27836 RESULTS +27837 OBJECTIVE +27838 CONCLUSIONS +27839 BACKGROUND +27840 BACKGROUND +27841 OBJECTIVE +27842 METHODS +27843 METHODS +27844 METHODS +27845 RESULTS +27846 RESULTS +27847 RESULTS +27848 RESULTS +27849 RESULTS +27850 CONCLUSIONS +27851 METHODS +27852 OBJECTIVE +27853 METHODS +27854 METHODS +27855 METHODS +27856 METHODS +27857 RESULTS +27858 RESULTS +27859 RESULTS +27860 RESULTS +27861 CONCLUSIONS +27862 OBJECTIVE +27863 METHODS +27864 METHODS +27865 RESULTS +27866 RESULTS +27867 RESULTS +27868 RESULTS +27869 RESULTS +27870 RESULTS +27871 CONCLUSIONS +27872 OBJECTIVE +27873 METHODS +27874 METHODS +27875 METHODS +27876 METHODS +27877 METHODS +27878 RESULTS +27879 RESULTS +27880 RESULTS +27881 RESULTS +27882 RESULTS +27883 CONCLUSIONS +27884 OBJECTIVE +27885 METHODS +27886 METHODS +27887 METHODS +27888 METHODS +27889 METHODS +27890 METHODS +27891 RESULTS +27892 CONCLUSIONS +27893 RESULTS +27894 RESULTS +27895 CONCLUSIONS +27896 CONCLUSIONS +27897 OBJECTIVE +27898 METHODS +27899 METHODS +27900 RESULTS +27901 RESULTS +27902 RESULTS +27903 RESULTS +27904 CONCLUSIONS +27905 BACKGROUND +27906 METHODS +27907 METHODS +27908 METHODS +27909 METHODS +27910 METHODS +27911 METHODS +27912 METHODS +27913 METHODS +27914 METHODS +27915 RESULTS +27916 RESULTS +27917 RESULTS +27918 CONCLUSIONS +27919 CONCLUSIONS +27920 BACKGROUND +27921 BACKGROUND +27922 OBJECTIVE +27923 METHODS +27924 METHODS +27925 RESULTS +27926 RESULTS +27927 RESULTS +27928 CONCLUSIONS +27929 BACKGROUND +27930 BACKGROUND +27931 OBJECTIVE +27932 METHODS +27933 RESULTS +27934 RESULTS +27935 RESULTS +27936 METHODS +27937 RESULTS +27938 CONCLUSIONS +27939 CONCLUSIONS +27940 OBJECTIVE +27941 METHODS +27942 METHODS +27943 METHODS +27944 METHODS +27945 RESULTS +27946 RESULTS +27947 RESULTS +27948 RESULTS +27949 RESULTS +27950 CONCLUSIONS +27951 CONCLUSIONS +27952 CONCLUSIONS +27953 BACKGROUND +27954 OBJECTIVE +27955 METHODS +27956 METHODS +27957 METHODS +27958 METHODS +27959 METHODS +27960 METHODS +27961 RESULTS +27962 RESULTS +27963 RESULTS +27964 CONCLUSIONS +27965 CONCLUSIONS +27966 BACKGROUND +27967 METHODS +27968 RESULTS +27969 RESULTS +27970 RESULTS +27971 RESULTS +27972 CONCLUSIONS +27973 CONCLUSIONS +27974 BACKGROUND +27975 OBJECTIVE +27976 METHODS +27977 METHODS +27978 METHODS +27979 METHODS +27980 RESULTS +27981 RESULTS +27982 CONCLUSIONS +27983 OBJECTIVE +27984 METHODS +27985 METHODS +27986 METHODS +27987 METHODS +27988 METHODS +27989 METHODS +27990 METHODS +27991 METHODS +27992 RESULTS +27993 RESULTS +27994 RESULTS +27995 RESULTS +27996 RESULTS +27997 RESULTS +27998 RESULTS +27999 RESULTS +28000 RESULTS +28001 RESULTS +28002 CONCLUSIONS +28003 OBJECTIVE +28004 METHODS +28005 METHODS +28006 METHODS +28007 METHODS +28008 RESULTS +28009 RESULTS +28010 RESULTS +28011 RESULTS +28012 RESULTS +28013 RESULTS +28014 CONCLUSIONS +28015 BACKGROUND +28016 BACKGROUND +28017 OBJECTIVE +28018 METHODS +28019 METHODS +28020 RESULTS +28021 RESULTS +28022 BACKGROUND +28023 BACKGROUND +28024 BACKGROUND +28025 BACKGROUND +28026 OBJECTIVE +28027 OBJECTIVE +28028 METHODS +28029 METHODS +28030 METHODS +28031 METHODS +28032 METHODS +28033 RESULTS +28034 RESULTS +28035 RESULTS +28036 RESULTS +28037 RESULTS +28038 RESULTS +28039 CONCLUSIONS +28040 RESULTS +28041 BACKGROUND +28042 BACKGROUND +28043 OBJECTIVE +28044 METHODS +28045 METHODS +28046 METHODS +28047 METHODS +28048 RESULTS +28049 CONCLUSIONS +28050 BACKGROUND +28051 BACKGROUND +28052 METHODS +28053 METHODS +28054 RESULTS +28055 RESULTS +28056 RESULTS +28057 RESULTS +28058 CONCLUSIONS +28059 CONCLUSIONS +28060 CONCLUSIONS +28061 OBJECTIVE +28062 METHODS +28063 METHODS +28064 METHODS +28065 METHODS +28066 METHODS +28067 RESULTS +28068 RESULTS +28069 RESULTS +28070 RESULTS +28071 RESULTS +28072 RESULTS +28073 RESULTS +28074 CONCLUSIONS +28075 OBJECTIVE +28076 METHODS +28077 METHODS +28078 METHODS +28079 METHODS +28080 METHODS +28081 RESULTS +28082 RESULTS +28083 RESULTS +28084 RESULTS +28085 CONCLUSIONS +28086 OBJECTIVE +28087 OBJECTIVE +28088 OBJECTIVE +28089 RESULTS +28090 METHODS +28091 RESULTS +28092 RESULTS +28093 RESULTS +28094 RESULTS +28095 CONCLUSIONS +28096 RESULTS +28097 CONCLUSIONS +28098 BACKGROUND +28099 OBJECTIVE +28100 OBJECTIVE +28101 METHODS +28102 METHODS +28103 METHODS +28104 RESULTS +28105 RESULTS +28106 RESULTS +28107 RESULTS +28108 CONCLUSIONS +28109 OBJECTIVE +28110 METHODS +28111 METHODS +28112 METHODS +28113 METHODS +28114 RESULTS +28115 RESULTS +28116 RESULTS +28117 RESULTS +28118 RESULTS +28119 CONCLUSIONS +28120 CONCLUSIONS +28121 OBJECTIVE +28122 METHODS +28123 METHODS +28124 METHODS +28125 RESULTS +28126 RESULTS +28127 CONCLUSIONS +28128 BACKGROUND +28129 BACKGROUND +28130 OBJECTIVE +28131 METHODS +28132 METHODS +28133 METHODS +28134 METHODS +28135 RESULTS +28136 RESULTS +28137 RESULTS +28138 CONCLUSIONS +28139 BACKGROUND +28140 OBJECTIVE +28141 METHODS +28142 METHODS +28143 METHODS +28144 RESULTS +28145 RESULTS +28146 RESULTS +28147 RESULTS +28148 RESULTS +28149 CONCLUSIONS +28150 OBJECTIVE +28151 OBJECTIVE +28152 METHODS +28153 METHODS +28154 METHODS +28155 RESULTS +28156 RESULTS +28157 RESULTS +28158 CONCLUSIONS +28159 RESULTS +28160 RESULTS +28161 RESULTS +28162 CONCLUSIONS +28163 RESULTS +28164 OBJECTIVE +28165 METHODS +28166 METHODS +28167 RESULTS +28168 RESULTS +28169 RESULTS +28170 CONCLUSIONS +28171 OBJECTIVE +28172 OBJECTIVE +28173 METHODS +28174 METHODS +28175 METHODS +28176 METHODS +28177 RESULTS +28178 RESULTS +28179 RESULTS +28180 RESULTS +28181 RESULTS +28182 RESULTS +28183 RESULTS +28184 CONCLUSIONS +28185 CONCLUSIONS +28186 BACKGROUND +28187 BACKGROUND +28188 BACKGROUND +28189 METHODS +28190 BACKGROUND +28191 OBJECTIVE +28192 METHODS +28193 METHODS +28194 METHODS +28195 RESULTS +28196 RESULTS +28197 RESULTS +28198 RESULTS +28199 CONCLUSIONS +28200 OBJECTIVE +28201 METHODS +28202 METHODS +28203 METHODS +28204 CONCLUSIONS +28205 CONCLUSIONS +28206 BACKGROUND +28207 BACKGROUND +28208 BACKGROUND +28209 METHODS +28210 METHODS +28211 METHODS +28212 METHODS +28213 RESULTS +28214 RESULTS +28215 RESULTS +28216 RESULTS +28217 CONCLUSIONS +28218 BACKGROUND +28219 CONCLUSIONS +28220 OBJECTIVE +28221 METHODS +28222 METHODS +28223 METHODS +28224 CONCLUSIONS +28225 RESULTS +28226 RESULTS +28227 RESULTS +28228 CONCLUSIONS +28229 CONCLUSIONS +28230 BACKGROUND +28231 BACKGROUND +28232 OBJECTIVE +28233 OBJECTIVE +28234 METHODS +28235 METHODS +28236 METHODS +28237 METHODS +28238 RESULTS +28239 RESULTS +28240 CONCLUSIONS +28241 RESULTS +28242 BACKGROUND +28243 BACKGROUND +28244 METHODS +28245 RESULTS +28246 RESULTS +28247 RESULTS +28248 RESULTS +28249 RESULTS +28250 CONCLUSIONS +28251 CONCLUSIONS +28252 BACKGROUND +28253 CONCLUSIONS +28254 METHODS +28255 METHODS +28256 RESULTS +28257 RESULTS +28258 RESULTS +28259 RESULTS +28260 RESULTS +28261 RESULTS +28262 RESULTS +28263 CONCLUSIONS +28264 CONCLUSIONS +28265 CONCLUSIONS +28266 OBJECTIVE +28267 CONCLUSIONS +28268 OBJECTIVE +28269 OBJECTIVE +28270 METHODS +28271 METHODS +28272 METHODS +28273 METHODS +28274 RESULTS +28275 RESULTS +28276 RESULTS +28277 CONCLUSIONS +28278 RESULTS +28279 CONCLUSIONS +28280 CONCLUSIONS +28281 OBJECTIVE +28282 METHODS +28283 METHODS +28284 METHODS +28285 RESULTS +28286 RESULTS +28287 CONCLUSIONS +28288 CONCLUSIONS +28289 BACKGROUND +28290 OBJECTIVE +28291 METHODS +28292 METHODS +28293 METHODS +28294 METHODS +28295 RESULTS +28296 RESULTS +28297 METHODS +28298 CONCLUSIONS +28299 OBJECTIVE +28300 OBJECTIVE +28301 METHODS +28302 METHODS +28303 METHODS +28304 METHODS +28305 BACKGROUND +28306 METHODS +28307 RESULTS +28308 RESULTS +28309 RESULTS +28310 CONCLUSIONS +28311 BACKGROUND +28312 BACKGROUND +28313 CONCLUSIONS +28314 OBJECTIVE +28315 METHODS +28316 METHODS +28317 METHODS +28318 METHODS +28319 RESULTS +28320 RESULTS +28321 RESULTS +28322 CONCLUSIONS +28323 OBJECTIVE +28324 METHODS +28325 METHODS +28326 METHODS +28327 METHODS +28328 RESULTS +28329 RESULTS +28330 RESULTS +28331 RESULTS +28332 CONCLUSIONS +28333 CONCLUSIONS +28334 BACKGROUND +28335 OBJECTIVE +28336 METHODS +28337 METHODS +28338 METHODS +28339 METHODS +28340 METHODS +28341 METHODS +28342 RESULTS +28343 RESULTS +28344 RESULTS +28345 RESULTS +28346 RESULTS +28347 CONCLUSIONS +28348 BACKGROUND +28349 BACKGROUND +28350 METHODS +28351 RESULTS +28352 RESULTS +28353 RESULTS +28354 RESULTS +28355 RESULTS +28356 CONCLUSIONS +28357 RESULTS +28358 CONCLUSIONS +28359 BACKGROUND +28360 BACKGROUND +28361 BACKGROUND +28362 OBJECTIVE +28363 METHODS +28364 METHODS +28365 METHODS +28366 RESULTS +28367 RESULTS +28368 RESULTS +28369 RESULTS +28370 CONCLUSIONS +28371 CONCLUSIONS +28372 RESULTS +28373 CONCLUSIONS +28374 OBJECTIVE +28375 METHODS +28376 METHODS +28377 METHODS +28378 METHODS +28379 METHODS +28380 METHODS +28381 METHODS +28382 RESULTS +28383 RESULTS +28384 RESULTS +28385 RESULTS +28386 RESULTS +28387 RESULTS +28388 RESULTS +28389 RESULTS +28390 RESULTS +28391 RESULTS +28392 RESULTS +28393 RESULTS +28394 RESULTS +28395 RESULTS +28396 CONCLUSIONS +28397 CONCLUSIONS +28398 BACKGROUND +28399 CONCLUSIONS +28400 BACKGROUND +28401 OBJECTIVE +28402 METHODS +28403 RESULTS +28404 RESULTS +28405 RESULTS +28406 RESULTS +28407 CONCLUSIONS +28408 BACKGROUND +28409 OBJECTIVE +28410 BACKGROUND +28411 METHODS +28412 METHODS +28413 RESULTS +28414 RESULTS +28415 RESULTS +28416 RESULTS +28417 CONCLUSIONS +28418 CONCLUSIONS +28419 BACKGROUND +28420 OBJECTIVE +28421 METHODS +28422 METHODS +28423 METHODS +28424 CONCLUSIONS +28425 CONCLUSIONS +28426 BACKGROUND +28427 BACKGROUND +28428 METHODS +28429 METHODS +28430 RESULTS +28431 RESULTS +28432 RESULTS +28433 RESULTS +28434 CONCLUSIONS +28435 CONCLUSIONS +28436 OBJECTIVE +28437 METHODS +28438 METHODS +28439 METHODS +28440 RESULTS +28441 RESULTS +28442 RESULTS +28443 RESULTS +28444 RESULTS +28445 RESULTS +28446 RESULTS +28447 OBJECTIVE +28448 METHODS +28449 METHODS +28450 RESULTS +28451 RESULTS +28452 RESULTS +28453 RESULTS +28454 CONCLUSIONS +28455 BACKGROUND +28456 METHODS +28457 METHODS +28458 RESULTS +28459 RESULTS +28460 RESULTS +28461 RESULTS +28462 CONCLUSIONS +28463 BACKGROUND +28464 OBJECTIVE +28465 METHODS +28466 METHODS +28467 METHODS +28468 METHODS +28469 METHODS +28470 METHODS +28471 METHODS +28472 CONCLUSIONS +28473 RESULTS +28474 RESULTS +28475 RESULTS +28476 CONCLUSIONS +28477 OBJECTIVE +28478 METHODS +28479 METHODS +28480 METHODS +28481 METHODS +28482 METHODS +28483 RESULTS +28484 RESULTS +28485 RESULTS +28486 RESULTS +28487 RESULTS +28488 RESULTS +28489 RESULTS +28490 RESULTS +28491 CONCLUSIONS +28492 RESULTS +28493 BACKGROUND +28494 BACKGROUND +28495 METHODS +28496 METHODS +28497 METHODS +28498 METHODS +28499 RESULTS +28500 RESULTS +28501 RESULTS +28502 RESULTS +28503 RESULTS +28504 RESULTS +28505 CONCLUSIONS +28506 CONCLUSIONS +28507 BACKGROUND +28508 BACKGROUND +28509 BACKGROUND +28510 BACKGROUND +28511 CONCLUSIONS +28512 METHODS +28513 METHODS +28514 METHODS +28515 RESULTS +28516 RESULTS +28517 RESULTS +28518 RESULTS +28519 RESULTS +28520 CONCLUSIONS +28521 METHODS +28522 METHODS +28523 METHODS +28524 RESULTS +28525 RESULTS +28526 RESULTS +28527 RESULTS +28528 RESULTS +28529 CONCLUSIONS +28530 CONCLUSIONS +28531 OBJECTIVE +28532 METHODS +28533 METHODS +28534 METHODS +28535 METHODS +28536 METHODS +28537 METHODS +28538 METHODS +28539 METHODS +28540 METHODS +28541 RESULTS +28542 RESULTS +28543 RESULTS +28544 RESULTS +28545 RESULTS +28546 RESULTS +28547 CONCLUSIONS +28548 CONCLUSIONS +28549 OBJECTIVE +28550 METHODS +28551 METHODS +28552 RESULTS +28553 RESULTS +28554 METHODS +28555 RESULTS +28556 RESULTS +28557 RESULTS +28558 RESULTS +28559 CONCLUSIONS +28560 BACKGROUND +28561 BACKGROUND +28562 BACKGROUND +28563 OBJECTIVE +28564 METHODS +28565 METHODS +28566 METHODS +28567 RESULTS +28568 CONCLUSIONS +28569 CONCLUSIONS +28570 OBJECTIVE +28571 METHODS +28572 METHODS +28573 METHODS +28574 METHODS +28575 METHODS +28576 RESULTS +28577 CONCLUSIONS +28578 BACKGROUND +28579 OBJECTIVE +28580 METHODS +28581 METHODS +28582 CONCLUSIONS +28583 RESULTS +28584 CONCLUSIONS +28585 RESULTS +28586 CONCLUSIONS +28587 CONCLUSIONS +28588 BACKGROUND +28589 BACKGROUND +28590 OBJECTIVE +28591 METHODS +28592 METHODS +28593 METHODS +28594 RESULTS +28595 RESULTS +28596 CONCLUSIONS +28597 CONCLUSIONS +28598 CONCLUSIONS +28599 BACKGROUND +28600 BACKGROUND +28601 METHODS +28602 METHODS +28603 METHODS +28604 METHODS +28605 RESULTS +28606 RESULTS +28607 RESULTS +28608 RESULTS +28609 RESULTS +28610 RESULTS +28611 RESULTS +28612 CONCLUSIONS +28613 CONCLUSIONS +28614 BACKGROUND +28615 METHODS +28616 METHODS +28617 METHODS +28618 METHODS +28619 METHODS +28620 RESULTS +28621 RESULTS +28622 RESULTS +28623 RESULTS +28624 RESULTS +28625 CONCLUSIONS +28626 BACKGROUND +28627 OBJECTIVE +28628 METHODS +28629 METHODS +28630 METHODS +28631 METHODS +28632 METHODS +28633 METHODS +28634 RESULTS +28635 RESULTS +28636 CONCLUSIONS +28637 CONCLUSIONS +28638 BACKGROUND +28639 BACKGROUND +28640 BACKGROUND +28641 METHODS +28642 METHODS +28643 METHODS +28644 METHODS +28645 METHODS +28646 RESULTS +28647 RESULTS +28648 RESULTS +28649 RESULTS +28650 RESULTS +28651 RESULTS +28652 RESULTS +28653 CONCLUSIONS +28654 BACKGROUND +28655 OBJECTIVE +28656 BACKGROUND +28657 BACKGROUND +28658 METHODS +28659 METHODS +28660 METHODS +28661 METHODS +28662 METHODS +28663 METHODS +28664 METHODS +28665 CONCLUSIONS +28666 RESULTS +28667 CONCLUSIONS +28668 CONCLUSIONS +28669 CONCLUSIONS +28670 OBJECTIVE +28671 METHODS +28672 METHODS +28673 RESULTS +28674 RESULTS +28675 CONCLUSIONS +28676 BACKGROUND +28677 BACKGROUND +28678 BACKGROUND +28679 METHODS +28680 METHODS +28681 METHODS +28682 METHODS +28683 METHODS +28684 METHODS +28685 METHODS +28686 METHODS +28687 RESULTS +28688 RESULTS +28689 RESULTS +28690 RESULTS +28691 RESULTS +28692 RESULTS +28693 RESULTS +28694 RESULTS +28695 CONCLUSIONS +28696 BACKGROUND +28697 METHODS +28698 OBJECTIVE +28699 BACKGROUND +28700 METHODS +28701 METHODS +28702 METHODS +28703 METHODS +28704 METHODS +28705 RESULTS +28706 RESULTS +28707 RESULTS +28708 RESULTS +28709 RESULTS +28710 RESULTS +28711 RESULTS +28712 CONCLUSIONS +28713 CONCLUSIONS +28714 METHODS +28715 OBJECTIVE +28716 METHODS +28717 METHODS +28718 METHODS +28719 METHODS +28720 METHODS +28721 METHODS +28722 RESULTS +28723 CONCLUSIONS +28724 RESULTS +28725 OBJECTIVE +28726 BACKGROUND +28727 METHODS +28728 METHODS +28729 RESULTS +28730 RESULTS +28731 RESULTS +28732 RESULTS +28733 RESULTS +28734 RESULTS +28735 RESULTS +28736 CONCLUSIONS +28737 CONCLUSIONS +28738 CONCLUSIONS +28739 BACKGROUND +28740 METHODS +28741 METHODS +28742 METHODS +28743 METHODS +28744 METHODS +28745 RESULTS +28746 RESULTS +28747 RESULTS +28748 RESULTS +28749 CONCLUSIONS +28750 CONCLUSIONS +28751 BACKGROUND +28752 BACKGROUND +28753 OBJECTIVE +28754 METHODS +28755 METHODS +28756 METHODS +28757 METHODS +28758 METHODS +28759 METHODS +28760 RESULTS +28761 RESULTS +28762 RESULTS +28763 RESULTS +28764 RESULTS +28765 CONCLUSIONS +28766 OBJECTIVE +28767 METHODS +28768 METHODS +28769 METHODS +28770 METHODS +28771 RESULTS +28772 RESULTS +28773 RESULTS +28774 RESULTS +28775 RESULTS +28776 RESULTS +28777 CONCLUSIONS +28778 BACKGROUND +28779 OBJECTIVE +28780 METHODS +28781 METHODS +28782 METHODS +28783 METHODS +28784 METHODS +28785 RESULTS +28786 RESULTS +28787 RESULTS +28788 CONCLUSIONS +28789 CONCLUSIONS +28790 OBJECTIVE +28791 METHODS +28792 METHODS +28793 METHODS +28794 RESULTS +28795 RESULTS +28796 RESULTS +28797 RESULTS +28798 RESULTS +28799 CONCLUSIONS +28800 METHODS +28801 METHODS +28802 RESULTS +28803 RESULTS +28804 RESULTS +28805 RESULTS +28806 RESULTS +28807 RESULTS +28808 CONCLUSIONS +28809 OBJECTIVE +28810 METHODS +28811 METHODS +28812 METHODS +28813 METHODS +28814 RESULTS +28815 RESULTS +28816 RESULTS +28817 RESULTS +28818 RESULTS +28819 CONCLUSIONS +28820 CONCLUSIONS +28821 BACKGROUND +28822 BACKGROUND +28823 METHODS +28824 METHODS +28825 METHODS +28826 METHODS +28827 METHODS +28828 RESULTS +28829 RESULTS +28830 RESULTS +28831 RESULTS +28832 RESULTS +28833 RESULTS +28834 CONCLUSIONS +28835 BACKGROUND +28836 BACKGROUND +28837 BACKGROUND +28838 RESULTS +28839 METHODS +28840 METHODS +28841 METHODS +28842 METHODS +28843 METHODS +28844 METHODS +28845 RESULTS +28846 RESULTS +28847 RESULTS +28848 RESULTS +28849 CONCLUSIONS +28850 CONCLUSIONS +28851 OBJECTIVE +28852 METHODS +28853 METHODS +28854 METHODS +28855 METHODS +28856 RESULTS +28857 RESULTS +28858 RESULTS +28859 RESULTS +28860 CONCLUSIONS +28861 OBJECTIVE +28862 METHODS +28863 METHODS +28864 METHODS +28865 METHODS +28866 METHODS +28867 METHODS +28868 RESULTS +28869 RESULTS +28870 RESULTS +28871 RESULTS +28872 CONCLUSIONS +28873 CONCLUSIONS +28874 BACKGROUND +28875 BACKGROUND +28876 METHODS +28877 METHODS +28878 RESULTS +28879 RESULTS +28880 RESULTS +28881 RESULTS +28882 RESULTS +28883 CONCLUSIONS +28884 RESULTS +28885 CONCLUSIONS +28886 OBJECTIVE +28887 BACKGROUND +28888 METHODS +28889 METHODS +28890 RESULTS +28891 RESULTS +28892 RESULTS +28893 RESULTS +28894 RESULTS +28895 CONCLUSIONS +28896 CONCLUSIONS +28897 BACKGROUND +28898 BACKGROUND +28899 OBJECTIVE +28900 METHODS +28901 METHODS +28902 METHODS +28903 METHODS +28904 METHODS +28905 METHODS +28906 METHODS +28907 RESULTS +28908 RESULTS +28909 CONCLUSIONS +28910 RESULTS +28911 RESULTS +28912 CONCLUSIONS +28913 CONCLUSIONS +28914 BACKGROUND +28915 BACKGROUND +28916 METHODS +28917 RESULTS +28918 METHODS +28919 METHODS +28920 METHODS +28921 RESULTS +28922 RESULTS +28923 RESULTS +28924 RESULTS +28925 RESULTS +28926 RESULTS +28927 CONCLUSIONS +28928 METHODS +28929 RESULTS +28930 RESULTS +28931 OBJECTIVE +28932 RESULTS +28933 METHODS +28934 RESULTS +28935 RESULTS +28936 RESULTS +28937 RESULTS +28938 CONCLUSIONS +28939 CONCLUSIONS +28940 BACKGROUND +28941 CONCLUSIONS +28942 BACKGROUND +28943 RESULTS +28944 RESULTS +28945 CONCLUSIONS +28946 BACKGROUND +28947 METHODS +28948 METHODS +28949 METHODS +28950 METHODS +28951 METHODS +28952 METHODS +28953 BACKGROUND +28954 OBJECTIVE +28955 METHODS +28956 METHODS +28957 RESULTS +28958 RESULTS +28959 RESULTS +28960 CONCLUSIONS +28961 CONCLUSIONS +28962 CONCLUSIONS +28963 OBJECTIVE +28964 METHODS +28965 METHODS +28966 METHODS +28967 METHODS +28968 METHODS +28969 RESULTS +28970 RESULTS +28971 RESULTS +28972 CONCLUSIONS +28973 BACKGROUND +28974 BACKGROUND +28975 METHODS +28976 METHODS +28977 METHODS +28978 RESULTS +28979 METHODS +28980 METHODS +28981 RESULTS +28982 RESULTS +28983 RESULTS +28984 RESULTS +28985 RESULTS +28986 RESULTS +28987 CONCLUSIONS +28988 OBJECTIVE +28989 METHODS +28990 METHODS +28991 METHODS +28992 METHODS +28993 RESULTS +28994 RESULTS +28995 RESULTS +28996 RESULTS +28997 CONCLUSIONS +28998 CONCLUSIONS +28999 BACKGROUND +29000 BACKGROUND +29001 OBJECTIVE +29002 METHODS +29003 METHODS +29004 METHODS +29005 METHODS +29006 RESULTS +29007 RESULTS +29008 RESULTS +29009 RESULTS +29010 CONCLUSIONS +29011 CONCLUSIONS +29012 CONCLUSIONS +29013 OBJECTIVE +29014 METHODS +29015 METHODS +29016 METHODS +29017 METHODS +29018 RESULTS +29019 RESULTS +29020 RESULTS +29021 CONCLUSIONS +29022 OBJECTIVE +29023 BACKGROUND +29024 OBJECTIVE +29025 METHODS +29026 METHODS +29027 METHODS +29028 RESULTS +29029 CONCLUSIONS +29030 CONCLUSIONS +29031 OBJECTIVE +29032 METHODS +29033 METHODS +29034 RESULTS +29035 RESULTS +29036 METHODS +29037 RESULTS +29038 RESULTS +29039 RESULTS +29040 CONCLUSIONS +29041 RESULTS +29042 RESULTS +29043 OBJECTIVE +29044 METHODS +29045 METHODS +29046 METHODS +29047 METHODS +29048 METHODS +29049 METHODS +29050 METHODS +29051 METHODS +29052 RESULTS +29053 RESULTS +29054 CONCLUSIONS +29055 OBJECTIVE +29056 METHODS +29057 METHODS +29058 METHODS +29059 METHODS +29060 METHODS +29061 METHODS +29062 METHODS +29063 METHODS +29064 METHODS +29065 RESULTS +29066 METHODS +29067 RESULTS +29068 RESULTS +29069 CONCLUSIONS +29070 CONCLUSIONS +29071 OBJECTIVE +29072 METHODS +29073 METHODS +29074 RESULTS +29075 RESULTS +29076 RESULTS +29077 RESULTS +29078 RESULTS +29079 CONCLUSIONS +29080 CONCLUSIONS +29081 CONCLUSIONS +29082 BACKGROUND +29083 BACKGROUND +29084 OBJECTIVE +29085 BACKGROUND +29086 OBJECTIVE +29087 METHODS +29088 METHODS +29089 METHODS +29090 RESULTS +29091 RESULTS +29092 RESULTS +29093 RESULTS +29094 CONCLUSIONS +29095 CONCLUSIONS +29096 BACKGROUND +29097 BACKGROUND +29098 METHODS +29099 RESULTS +29100 RESULTS +29101 RESULTS +29102 RESULTS +29103 RESULTS +29104 RESULTS +29105 CONCLUSIONS +29106 CONCLUSIONS +29107 BACKGROUND +29108 BACKGROUND +29109 METHODS +29110 METHODS +29111 METHODS +29112 METHODS +29113 METHODS +29114 METHODS +29115 METHODS +29116 RESULTS +29117 RESULTS +29118 RESULTS +29119 RESULTS +29120 CONCLUSIONS +29121 BACKGROUND +29122 BACKGROUND +29123 OBJECTIVE +29124 METHODS +29125 METHODS +29126 RESULTS +29127 RESULTS +29128 RESULTS +29129 RESULTS +29130 RESULTS +29131 CONCLUSIONS +29132 OBJECTIVE +29133 METHODS +29134 METHODS +29135 METHODS +29136 METHODS +29137 METHODS +29138 METHODS +29139 METHODS +29140 METHODS +29141 RESULTS +29142 RESULTS +29143 CONCLUSIONS +29144 CONCLUSIONS +29145 OBJECTIVE +29146 METHODS +29147 METHODS +29148 METHODS +29149 METHODS +29150 RESULTS +29151 RESULTS +29152 RESULTS +29153 RESULTS +29154 RESULTS +29155 RESULTS +29156 CONCLUSIONS +29157 BACKGROUND +29158 BACKGROUND +29159 METHODS +29160 METHODS +29161 METHODS +29162 METHODS +29163 METHODS +29164 RESULTS +29165 RESULTS +29166 RESULTS +29167 CONCLUSIONS +29168 CONCLUSIONS +29169 OBJECTIVE +29170 METHODS +29171 METHODS +29172 METHODS +29173 METHODS +29174 METHODS +29175 METHODS +29176 RESULTS +29177 RESULTS +29178 RESULTS +29179 RESULTS +29180 CONCLUSIONS +29181 CONCLUSIONS +29182 OBJECTIVE +29183 METHODS +29184 METHODS +29185 METHODS +29186 METHODS +29187 RESULTS +29188 RESULTS +29189 CONCLUSIONS +29190 OBJECTIVE +29191 METHODS +29192 METHODS +29193 METHODS +29194 METHODS +29195 METHODS +29196 RESULTS +29197 RESULTS +29198 RESULTS +29199 RESULTS +29200 RESULTS +29201 CONCLUSIONS +29202 CONCLUSIONS +29203 OBJECTIVE +29204 OBJECTIVE +29205 METHODS +29206 METHODS +29207 METHODS +29208 METHODS +29209 METHODS +29210 RESULTS +29211 RESULTS +29212 CONCLUSIONS +29213 BACKGROUND +29214 BACKGROUND +29215 BACKGROUND +29216 OBJECTIVE +29217 METHODS +29218 RESULTS +29219 RESULTS +29220 CONCLUSIONS +29221 OBJECTIVE +29222 METHODS +29223 METHODS +29224 METHODS +29225 METHODS +29226 METHODS +29227 METHODS +29228 OBJECTIVE +29229 RESULTS +29230 RESULTS +29231 RESULTS +29232 RESULTS +29233 RESULTS +29234 RESULTS +29235 RESULTS +29236 CONCLUSIONS +29237 CONCLUSIONS +29238 OBJECTIVE +29239 METHODS +29240 METHODS +29241 METHODS +29242 METHODS +29243 METHODS +29244 METHODS +29245 METHODS +29246 RESULTS +29247 RESULTS +29248 CONCLUSIONS +29249 OBJECTIVE +29250 OBJECTIVE +29251 OBJECTIVE +29252 METHODS +29253 METHODS +29254 METHODS +29255 RESULTS +29256 RESULTS +29257 RESULTS +29258 RESULTS +29259 CONCLUSIONS +29260 BACKGROUND +29261 METHODS +29262 METHODS +29263 RESULTS +29264 RESULTS +29265 RESULTS +29266 RESULTS +29267 RESULTS +29268 RESULTS +29269 RESULTS +29270 CONCLUSIONS +29271 BACKGROUND +29272 BACKGROUND +29273 OBJECTIVE +29274 METHODS +29275 METHODS +29276 METHODS +29277 RESULTS +29278 BACKGROUND +29279 BACKGROUND +29280 CONCLUSIONS +29281 BACKGROUND +29282 OBJECTIVE +29283 METHODS +29284 RESULTS +29285 RESULTS +29286 CONCLUSIONS +29287 BACKGROUND +29288 BACKGROUND +29289 BACKGROUND +29290 METHODS +29291 RESULTS +29292 RESULTS +29293 CONCLUSIONS +29294 CONCLUSIONS +29295 OBJECTIVE +29296 METHODS +29297 METHODS +29298 METHODS +29299 METHODS +29300 METHODS +29301 RESULTS +29302 CONCLUSIONS +29303 RESULTS +29304 RESULTS +29305 RESULTS +29306 CONCLUSIONS +29307 RESULTS +29308 BACKGROUND +29309 BACKGROUND +29310 OBJECTIVE +29311 METHODS +29312 METHODS +29313 RESULTS +29314 RESULTS +29315 RESULTS +29316 RESULTS +29317 RESULTS +29318 OBJECTIVE +29319 METHODS +29320 METHODS +29321 METHODS +29322 RESULTS +29323 METHODS +29324 RESULTS +29325 RESULTS +29326 RESULTS +29327 RESULTS +29328 RESULTS +29329 CONCLUSIONS +29330 BACKGROUND +29331 BACKGROUND +29332 CONCLUSIONS +29333 BACKGROUND +29334 BACKGROUND +29335 METHODS +29336 METHODS +29337 METHODS +29338 METHODS +29339 METHODS +29340 METHODS +29341 METHODS +29342 RESULTS +29343 RESULTS +29344 RESULTS +29345 CONCLUSIONS +29346 CONCLUSIONS +29347 BACKGROUND +29348 BACKGROUND +29349 BACKGROUND +29350 BACKGROUND +29351 BACKGROUND +29352 METHODS +29353 METHODS +29354 METHODS +29355 METHODS +29356 METHODS +29357 METHODS +29358 CONCLUSIONS +29359 BACKGROUND +29360 CONCLUSIONS +29361 BACKGROUND +29362 OBJECTIVE +29363 METHODS +29364 METHODS +29365 METHODS +29366 METHODS +29367 METHODS +29368 METHODS +29369 RESULTS +29370 RESULTS +29371 RESULTS +29372 CONCLUSIONS +29373 RESULTS +29374 OBJECTIVE +29375 METHODS +29376 METHODS +29377 METHODS +29378 RESULTS +29379 RESULTS +29380 CONCLUSIONS +29381 BACKGROUND +29382 BACKGROUND +29383 METHODS +29384 METHODS +29385 RESULTS +29386 RESULTS +29387 CONCLUSIONS +29388 CONCLUSIONS +29389 CONCLUSIONS +29390 BACKGROUND +29391 BACKGROUND +29392 BACKGROUND +29393 METHODS +29394 RESULTS +29395 RESULTS +29396 RESULTS +29397 RESULTS +29398 RESULTS +29399 BACKGROUND +29400 OBJECTIVE +29401 METHODS +29402 METHODS +29403 RESULTS +29404 RESULTS +29405 RESULTS +29406 RESULTS +29407 CONCLUSIONS +29408 BACKGROUND +29409 BACKGROUND +29410 OBJECTIVE +29411 METHODS +29412 METHODS +29413 METHODS +29414 RESULTS +29415 RESULTS +29416 CONCLUSIONS +29417 OBJECTIVE +29418 METHODS +29419 METHODS +29420 METHODS +29421 METHODS +29422 METHODS +29423 METHODS +29424 RESULTS +29425 RESULTS +29426 CONCLUSIONS +29427 BACKGROUND +29428 BACKGROUND +29429 METHODS +29430 METHODS +29431 RESULTS +29432 RESULTS +29433 CONCLUSIONS +29434 CONCLUSIONS +29435 BACKGROUND +29436 BACKGROUND +29437 OBJECTIVE +29438 METHODS +29439 METHODS +29440 METHODS +29441 METHODS +29442 METHODS +29443 RESULTS +29444 CONCLUSIONS +29445 OBJECTIVE +29446 METHODS +29447 METHODS +29448 RESULTS +29449 RESULTS +29450 RESULTS +29451 RESULTS +29452 CONCLUSIONS +29453 OBJECTIVE +29454 METHODS +29455 METHODS +29456 METHODS +29457 METHODS +29458 METHODS +29459 RESULTS +29460 RESULTS +29461 RESULTS +29462 CONCLUSIONS +29463 CONCLUSIONS +29464 CONCLUSIONS +29465 OBJECTIVE +29466 METHODS +29467 METHODS +29468 METHODS +29469 RESULTS +29470 RESULTS +29471 RESULTS +29472 RESULTS +29473 CONCLUSIONS +29474 BACKGROUND +29475 OBJECTIVE +29476 METHODS +29477 METHODS +29478 RESULTS +29479 RESULTS +29480 CONCLUSIONS +29481 BACKGROUND +29482 OBJECTIVE +29483 METHODS +29484 METHODS +29485 METHODS +29486 RESULTS +29487 RESULTS +29488 RESULTS +29489 RESULTS +29490 RESULTS +29491 CONCLUSIONS +29492 CONCLUSIONS