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Ġbet ween a v pe ct 2 3 Ġ af Ġre g o und Ġs ub m i Ġ Z Ġus ing Ġd ata Ġef fect Ġe v it e il ity be r r v âĪ Ĵ os e im e ro n lo g Ġ ant Ġ en a k 2 4 n c p l  ± Ġ y Ġres ult o we l es Ġ k 3 8 as s Ġgro up alt h Ġ âĢĵ Ġca n ut ion Ġs ign 2 6 Ġm e ul ation r ic âĢ Ļ press ion T he ar i Ġm ic ul d r al 2 8 0 5 = = n y 2 7 Ġg en n es ug h Ġg ene a ce c ent c ri Ġact iv Ġs ur 2 00 Ġ ar 2 9 Ġs c Ġin creas Ġsign ific Ġus ed cl ud so ci Ġs u is s tr ib r y am e ha ng o us Ġ2 0 Ġd i Ġal so a il Ġs pe Ġ un he n 3 3 Ġpr es Ġpro tei Ġ und Ġc or Ġanal ysis Ġp h or k Ġthe r Ċ Ċ ance r un ction e g h r ys te ed ic f ic âĢ IJ Ġdiffer ent eat ment Ġ qu Ġ te ac k Ġp os Ġle vel g en act e Ġh as t est at ing n i Ġsignific ant enc es e rs t han he m Ġas s Ġ : Ġ ro i nal Ġ = l u Ġbe en Ġf r 3 0 Ġ than Ġ el 2 1 c om u ction Ġmod el n is al u ĠB io Ġh igh Ġthe ir m al Ġd o io us 3 6 5 0 as ed Ġal l r g ĠR es ho d i ed Ġc l ĉ Ċ Ġcomp ar 3 4 Ġm i Ġ ag or d Ġd es Ġh y ur es m at ĠA l ant s 1 00 3 7 Ġthe se eas e Ġ am Ġs y 3 9 ur ing Ġin v Ġo ther Ġ tw 3 5 u ro Ġtr eatment Ġin clud 2 2 o ut Ġaf ter 1 01 ive rs r ed iz ed Ġg r ĠH e ĠS t Ġcont rol Ġo ut Ġm ore 4 0 ri al ia n Ġad d ot h ed i Ġf act uc ed t ime t ed Ġex pression r ation Ġm ay ie w n ed Ġin f Ġ Î Ġ test Ġf ol Ġres po p os ĠU n us e Ġas soci 4 5 n ation ĠS ci Ġpr ev Ġtw o Ġre port Ġo ver Ġs up ear ch ar g iv ely c k Fig ure Ġr ed % ) Ġ X Ġs amp Ġco nd Ġs yste Ġund e n os 4 9 ce pt h ib 4 6 olog y ĠN e Ġpar tic il d Ġco m Ġf unction a no de r Ġl i Ġstud ies t t ĠT his ve rs um a Ġper form lin ical Ġb io Ġresult s Ġs o Ġco l ate r 4 8 Ġs p a ys 4 7 r es he d p s ain ed iz ation Ġ ; Ġus e Ġ âĢ at ure Ġb ut 9 5 d ent Ġ time o u ai ns al e if ied c ur o ne ci al ent ial n n k i Ġn um Ġpro v r el Ġm eas 101 6 8 6 t al c ular Ġfol low en g vel op Ġ1 5 Ġrespo ns j ect ĠP ro Ġde velop 9 7 it ive ab ility Ġind ic Ġprotei n Ġap pro Ġv ari Ġc r Ġunde r Ġe ach Ġd uring ment s b i e x Ġc ancer Ġb r h ro Ġma n uma n ĠW e is k i nt ut h Ġob se n k 9 9 ivers ity Ġdis ease Ġo ne C o act ion 8 0 ĠM ed it ies Ġi mm ĠF ig Ġ1 6 Ġi dent ĠA s v i it ed Ġc hang owe ver ĠR e t hr Ġ up le ment it al Ġsu ch ain ing Ġc y Ġpro d u te Ġp ol t s Ġin to t a 9 0 ic s Ġ ty c ul ur al Ġobse rv S A ind ing os p 7 5 Ġmet hod Ġb oth Ġpres ent I n e qu a ir cri pt f i Ġo ur Ġ ± s is v ed c ific mo ns io r Ġh ad for e per im Ġhe alth âĢ Ķ it s as es Ġ ) ical ly Ġit s Ġc ar 6 5 Ġther e no w od y Ġ thr enc y ic e i ent l ed 3 2 8 5 Ġ Q c ord c a Ġf ound 6 7 ol d Ġno n Ġh ig ch a Ġs el t hro 6 0 4 4 s y R NA ation al if e Ġlevel s t um Ġb lo ir st Ġpr e Ġnum ber ib le ĠP h 9 8 Ġcomp le Ġon ly ent ion le r Ġs im 7 7 ĠP r ĠL i Ġ end 00 0 Ġin hib Ġap p ur ther n ing im al Ġc linical Ġr at / / Ġactiv ity ad e am i Ġassoci ated 3 1 Ġ tum ific ation : // e ction Ġfor m Ġi m Ġcompar ed Ġr isk r is ro b Ġp o Ġs h u ng âĢ Ŀ ar acte l is or g Ġp ot log y C A Ġv al ag es us t al ity Ġf i Ġd r I D at h iz e Ġpro cess r t 9 6 arg et ent al ig nal ] , Ġre v Ġh uman ter s form ation iv id ĠUn iversity o od Ġ1 2 fe ction Ġshow n Ġadd ition ro p a ny Ġ thro 7 0 Ġst at Ġex perim a u Ġm ost Ġw ell Ġreport ed Ġm ult Ġc ur Ġ1 8 mo n 5 5 Ġl oc Ġs ug Ġw ork or mal Ġco uld at ory o x Ġsyste m ap y s tr Ġstr uct Ġse qu ĠT r id ence Ġw ho g est tr y her e owe r C T trib ution ma n te ct Ġp op a w 00 00 Ġpat h ĠâĢ ľ il ar Ġf e ĠĠ ĠĠ ĠC O Ġcon f 9 3 ter mi Ġ est is e Ġhig her ĠC h  ° tic s ir us trib ut 4 2 T able n ess Ġperform ed pr es Ġc al 8 8 ĠF or ĠH owever le ct ĠD e et ic Ġeffect s ci es Ġw hen Ġ1 7 Ġs ol Ġ2 5 Ġcond ition u nt Ġpartic ip ar ge Ġl ow ĠHe alth Ġ20 20 Ġgen es Ġ j 4 3 tr ic C R Ġsug gest Ġin t l am Ġobserv ed Ġincreas ed Ġse ver Ġy ear ĠA c uc le Ġm em Ġs ignal Ġthr ee Ġ3 0 Ġf irst qu ir Ġin c ar k end ent ver y ag nos Ġex tr Ġres pect 6 6 a uth o v Ġshow ed Ġ2 02 Ġac id ate rial Ġs i Ġch aracte t arget Ġass ess hi le âĢ ĥ Ġthe y ĠThe r el d to n ke r ĠE x Ġ auth Ġmic e b r 7 1 Ġthro ugh Ġgro w or es t ing Ġmi n Ġimp ort e f osp ital Ġpot ential 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e Ġg u Ġpr act the li Ġr andom ĠChi na Ġm us amp le Ġconside red ib ility Ġw omen Ġdiffer ence Ġad v 10 38 f s M C ve ment rel ated os is Ġtr eated Ġdo i l or A D Ġ200 7 abet es Ġe arly Ġv ia oc y ge ry Ġrecept or ĠD i mat ory Ġexperim ents ir e Ġappro ach ĠC I N o Ġloc al Ġf our Ġe mp he no Ġv s Ġmo nt ĠP ar o le ist ical Ġ2 6 Ġrel ationship Ġh ospital ĠSci ence O S Ġred uced ĠE n ĠIns tit Ġac cess Ġat t Ġac cording Ġb inding og en our ce Ġqu ality Ġsever al s te Ġter ms Ġ2 8 Ġf eat Ġpr ep Ġtempe rature v es Ġau to r ations E S R es Ġma ny ĠD epartment is ed i j Ġ tim Ġwe ek Ġco nce ĠZ hang n el Ġ ke Ġst ate . - u le Ġli k Ġposs ible Ġm it r ated i ther mi nis Ġr ange pro d y ear y e end ed et s Ġl ip Ġh is Ġex ami Ġco un N P ci no a h Î ¼ e rv led ge B S be rs Ġre cent t ub Ġprod uction Ġ + Ġ2 7 Ġcol lect ens ion Ġ200 6 o ve ĠJ ournal it ation Ġ es ir al Ġconf ir O R Ġanalys es S D Ġn ano ĠF e Ġbe ing Ġqu est Ġmedi um Ġare a am s ter ed Ġph ase ul ations ĠMed ical te gr Ġres istance Ġex peri Ġsymp to Ġfunction al li ed el ine Ġpathw ay n ia Ġf em Ġen vironment le x n ary Ġde gr Ġsignal ing arm ac Ġal low Ġcor respond Ġhy po ig en ol es Ġsurv ival M I Ġ2 3 Ġreg ion Ġf ac Ġprevious ly Ġhy dro cl usion ho ol Ġindic ated h ort n ant o id Ġ very Ġre com Ġre f Ġprod uct ĠF urther ur y S t ta ke ĠM edicine gen ic Ġperform ance ur ation Ġs cr Ġpredic t Ġm ight ap s Ġ2 2 Ġanaly zed 20 20 c he A s Ġ9 5 Ġv acci ing s ĠM D ĠCo n a nn ĠSt ud Ġaf fect Ġneg ative Ġpresent ed Ġd ay ĠF ront Ġpro gram ĠE ng Ġstr ateg Ġexpress ed C O Ġb ody at ively es h l ight us tr Ġcomp o Ġcompo n Ġl ung ng e Ġw or ĠC A Ġdis or op h Ġdiagnos is ar ch Ġl oss % , Ġimmu no Ġinvol ved x i e ad ĠTr ans ual ly Ġimmu ne r ess m ar a ni Ġreg ard as k o nal Ġ200 5 100 7 Ġcharacteris tics Ġre ad Ġthe m Ġout comes ho nd ar r nation al Ġextr act to sis l ant nt rol ĠG u ĠP ub theli al 201 6 ther apy 201 5 a verage pert ies l ation Ġmole cular Ġaddition al ĠE v or b Ġb el uli n c ence Ġsc ore Ġdetermi ned t and u mp am ine x ed ĠM ol ho to âĢ Ĭ E T Ġop en ĠE d Ġin st Ġac ross ci p Ġ2 1 Ġparame ters as is ition al Ġres id 201 7 Ġde ath Ġpr ess Ġsequ ence Ġwhe ther Ġp heno C s op le Ġind ependent Ġund ers ĠA nal M A l ife Ġform ation Ġpat ho i k 201 4 Ġdemonstr ated yn am Ġcomp os s pecific Ġstat us e c Ġconduct ed Ġmembra ne ĠO n iv ing ĠP L Ġor der Ġvar ious ar a Ġorig inal li ke at ors ĠâĢ ĺ enc ing Ġad j Ġ ent C l im i vers e Ġpartic ular us cript Ġm ass ol y Ġso cial ic ense c um ell ular 201 3 Ġtr a Ġm ac Ġinhib it m edi c al C I Ġ ene Ġcalcul ated ort ality ri ed Ġknow n h ol Ġindividual s Ġf oc ĠE f we r Ġ2 9 ĠThere fore Ġb l Ġ average en z u ne t ak ur s ĠNe u ĠB o Ġsympto ms Ġm ade Ġp ain no t Ġrespons es Ġ4 0 Ġl iver Ġo l ĠĠĠĠ ĠĠĠĠ ne y Ġl ymp om es Ġch rom Ġse rum Ġshow s ĠM ore r c b a Ġsel f Ġassoci ation Ġpro ced chn ology or ed a im Ġman uscript Ġcl us i nu pect ive hod s Ġhe l Ġre mo it ivity Ġl ife ĠH ospital Ġsu per Ġf at 201 2 ĠF r G G Ġse rv fici ency r ap tr ans l ess 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