zurlog/subset_wlabels huggingface dataset:
Title: pocovid-net: automatic detection of covid-19 from a new lung ultrasound imaging dataset (pocus)
Published: 2021-01-24 (Preprint, arXiv)
Condition: COVID-19;Pneumonia, Bacterial
Task: 2. Detection/Diagnosis | Modality: Ultrasound

Abstract: With the rapid development of COVID-19 into a global pandemic, there is an ever more urgent need for cheap, fast and reliable tools that can assist physicians in diagnosing COVID-19. Medical imaging such as CT can take a key role in complementing conventional diagnostic tools from molecular biology, and, using deep learning techniques, several automatic systems were demonstrated promising performances using CT or X-ray data. Here, we advocate a more prominent role of point-of-care ultrasound imaging to guide COVID-19 detection. Ultrasound is non-invasive and ubiquitous in medical facilities around the globe. Our contribution is threefold. First, we gather a lung ultrasound (POCUS) dataset consisting of 1103 images (654 COVID-19, 277 bacterial pneumonia and 172 healthy controls), sampled from 64 videos. This dataset was assembled from various online sources, processed specifically for deep learning models and is intended to serve as a starting point for an open-access initiative. Second, we train a deep convolutional neural network (POCOVID-Net) on this 3-class dataset and achieve an accuracy of 89% and, by a majority vote, a video accuracy of 92% . For detecting COVID-19 in particular, the model performs with a sensitivity of 0.96, a specificity of 0.79 and F1-score of 0.92 in a 5-fold cross validation. Third, we provide an open-access web service (POCOVIDScreen) that is available at: . The website deploys the predictive model, allowing to perform predictions on ultrasound lung images. In addition, it grants medical staff the option to (bulk) upload their own screenings in order to contribute to the growing public database of pathological lung ultrasound images. Dataset and code are available from: GitHub This preprint is superseded by our paper in Applied Sciences:
Title: novel deep learning technique used in management and discharge of hospitalized patients with covid-19 in china
Journal: Ther Clin Risk Manag
Published: 2020-12-17 (Journal Article, Peer reviewed (PubMed))
Condition: COVID-19;Fibrosis;Lymphadenopathy;Pneumonia
Task: 5. Post-hoc | Modality: CT

Abstract: The low sensitivity and false-negative results of nucleic acid testing greatly affect its performance in diagnosing and discharging patients with coronavirus disease (COVID-19). Chest computed tomography (CT)-based evaluation of pneumonia may indicate a need for isolation. Therefore, this radiologic modality plays an important role in managing patients with suspected COVID-19. Meanwhile, deep learning (DL) technology has been successful in detecting various imaging features of chest CT. This study applied a novel DL technique to standardize the discharge criteria of COVID-19 patients with consecutive negative respiratory pathogen nucleic acid test results at a "square cabin" hospital. DL was used to evaluate the chest CT scans of 270 hospitalized COVID-19 patients who had two consecutive negative nucleic acid tests (sampling interval >1 day). The CT scans evaluated were obtained after the patients' second negative test result. The standard criterion determined by DL for patient discharge was a total volume ratio of lesion to lung <50%. The mean number of days between hospitalization and DL was 14.3 . The average intersection over union was 0.7894. Two hundred and thirteen patients exhibited pneumonia, of whom 54.0% had mild interstitial fibrosis. Twenty-one, 33, and 4 cases exhibited vascular enlargement, pleural thickening, and mediastinal lymphadenopathy, respectively. Of the latter, 18.8% had a total volume ratio of lesions to lung ≥50% according to our severity scale and were monitored continuously in the hospital. Three cases had a positive follow-up nucleic acid test during hospitalization. None of the 230 discharged cases later tested positive or exhibited pneumonia progression. The novel DL enables the accurate management of hospitalized patients with COVID-19 and can help avoid cluster transmission or exacerbation in patients with false-negative acid test.
Title: an efficient mixture of deep and machine learning models for covid-19 and tuberculosis detection using x-ray images in resource limited settings
Published: 2020-07-16 (Preprint, arXiv)
Condition: COVID-19;Cough;Fever;Pneumonia, Bacterial;Pneumonia, Viral;Tuberculosis
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: Clinicians in the frontline need to assess quickly whether a patient with symptoms indeed has COVID-19 or not. The difficulty of this task is exacerbated in low resource settings that may not have access to biotechnology tests. Furthermore, Tuberculosis (TB) remains a major health problem in several low- and middle-income countries and its common symptoms include fever, cough and tiredness, similarly to COVID-19. In order to help in the detection of COVID-19, we propose the extraction of deep features (DF) from chest X-ray images, a technology available in most hospitals, and their subsequent classification using machine learning methods that do not require large computational resources. We compiled a five-class dataset of X-ray chest images including a balanced number of COVID-19, viral pneumonia, bacterial pneumonia, TB, and healthy cases. We compared the performance of pipelines combining 14 individual state-of-the-art pre-trained deep networks for DF extraction with traditional machine learning classifiers. A pipeline consisting of ResNet-50 for DF computation and ensemble of subspace discriminant classifier was the best performer in the classification of the five classes, achieving a detection accuracy of 91.6+ 2.6% (accuracy + 95% Confidence Interval). Furthermore, the same pipeline achieved accuracies of 98.6+1.4% and 99.9+0.5% in simpler three-class and two-class classification problems focused on distinguishing COVID-19, TB and healthy cases; and COVID-19 and healthy images, respectively. The pipeline was computationally efficient requiring just 0.19 second to extract DF per X-ray image and 2 minutes for training a traditional classifier with more than 2000 images on a CPU machine. The results suggest the potential benefits of using our pipeline in the detection of COVID-19, particularly in resource-limited settings and it can run with limited computational resources.
Title: covid-resnet: a deep learning framework for screening of covid-19 from radiographs
Published: 2020-03-31 (Preprint, arXiv)
Condition: COVID-19;COVID-19 Pandemic;Infections;Pneumonia
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: In the last few months, the novel COVID19 pandemic has spread all over the world. Due to its easy transmission, developing techniques to accurately and easily identify the presence of COVID19 and distinguish it from other forms of flu and pneumonia is crucial. Recent research has shown that the chest Xrays of patients suffering from COVID19 depicts certain abnormalities in the radiography. However, those approaches are closed source and not made available to the research community for re-producibility and gaining deeper insight. The goal of this work is to build open source and open access datasets and present an accurate Convolutional Neural Network framework for differentiating COVID19 cases from other pneumonia cases. Our work utilizes state of the art training techniques including progressive resizing, cyclical learning rate finding and discriminative learning rates to training fast and accurate residual neural networks. Using these techniques, we showed the state of the art results on the open-access COVID-19 dataset. This work presents a 3-step technique to fine-tune a pre-trained ResNet-50 architecture to improve model performance and reduce training time. We call it COVIDResNet. This is achieved through progressively re-sizing of input images to 128x128x3, 224x224x3, and 229x229x3 pixels and fine-tuning the network at each stage. This approach along with the automatic learning rate selection enabled us to achieve the state of the art accuracy of 96.23% (on all the classes) on the COVIDx dataset with only 41 epochs. This work presented a computationally efficient and highly accurate model for multi-class classification of three different infection types from along with Normal individuals. This model can help in the early screening of COVID19 cases and help reduce the burden on healthcare systems.
Title: temporal changes of covid-19 pneumonia by mass evaluation using ct: a retrospective multi-center study
Journal: Ann Transl Med
Published: 2020-09-22 (Journal Article, Peer reviewed (PubMed))
Condition: COVID-19;Disease Progression;Infections;Pneumonia
Task: 3. Monitoring/Severity assessment | Modality: CT

Abstract: Coronavirus disease 2019 (COVID-19) has widely spread worldwide and caused a pandemic. Chest CT has been found to play an important role in the diagnosis and management of COVID-19. However, quantitatively assessing temporal changes of COVID-19 pneumonia over time using CT has still not been fully elucidated. The purpose of this study was to perform a longitudinal study to quantitatively assess temporal changes of COVID-19 pneumonia. This retrospective and multi-center study included patients with laboratory-confirmed COVID-19 infection from 16 hospitals between January 19 and March 27, 2020. Mass was used as an approach to quantitatively measure dynamic changes of pulmonary involvement in patients with COVID-19. Artificial intelligence (AI) was employed as image segmentation and analysis tool for calculating the mass of pulmonary involvement. A total of 581 confirmed patients with 1,309 chest CT examinations were included in this study. The median age was 46 years (IQR, 35-55; range, 4-87 years), and 311 patients were male. The mass of pulmonary involvement peaked on day 10 after the onset of initial symptoms. Furthermore, the mass of pulmonary involvement of older patients (>45 years) was significantly severer (P<0.001) and peaked later (day 11 vs. day 8) than that of younger patients (≤45 years). In addition, there were no significant differences in the peak time (day 10 vs. day 10) and median mass (P=0.679) of pulmonary involvement between male and female. Pulmonary involvement peaked on day 10 after the onset of initial symptoms in patients with COVID-19. Further, pulmonary involvement of older patients was severer and peaked later than that of younger patients. These findings suggest that AI-based quantitative mass evaluation of COVID-19 pneumonia hold great potential for monitoring the disease progression.
Title: a deep learning approach to detect covid-19 coronavirus with x-ray images
Journal: Biocybern Biomed Eng
Published: 2020-09-15 (Journal Article, Peer reviewed (PubMed))
Condition: COVID-19;Pneumonia
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: Rapid and accurate detection of COVID-19 coronavirus is necessity of time to prevent and control of this pandemic by timely quarantine and medical treatment in absence of any vaccine. Daily increase in cases of COVID-19 patients worldwide and limited number of available detection kits pose difficulty in identifying the presence of disease. Therefore, at this point of time, necessity arises to look for other alternatives. Among already existing, widely available and low-cost resources, X-ray is frequently used imaging modality and on the other hand, deep learning techniques have achieved state-of-the-art performances in computer-aided medical diagnosis. Therefore, an alternative diagnostic tool to detect COVID-19 cases utilizing available resources and advanced deep learning techniques is proposed in this work. The proposed method is implemented in four phases, viz., data augmentation, preprocessing, stage-I and stage-II deep network model designing. This study is performed with online available resources of 1215 images and further strengthen by utilizing data augmentation techniques to provide better generalization of the model and to prevent the model overfitting by increasing the overall length of dataset to 1832 images. Deep network implementation in two stages is designed to differentiate COVID-19 induced pneumonia from healthy cases, bacterial and other virus induced pneumonia on X-ray images of chest. Comprehensive evaluations have been performed to demonstrate the effectiveness of the proposed method with both training-validation-testing and 5-fold cross validation procedures. High classification accuracy as 97.77%, recall as 97.14% and precision as 97.14% in case of COVID-19 detection shows the efficacy of proposed method in present need of time. Further, the deep network architecture showing averaged accuracy/sensitivity/specificity/precision/F1-score of 98.93/98.93/98.66/96.39/98.15 with 5-fold cross validation makes a promising outcome in COVID-19 detection using X-ray images.
Title: cvr-net: a deep convolutional neural network for coronavirus recognition from chest radiography images
Published: 2020-07-21 (Preprint, arXiv)
Condition: COVID-19
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: The novel Coronavirus Disease 2019 (COVID-19) is a global pandemic disease spreading rapidly around the world. A robust and automatic early recognition of COVID-19, via auxiliary computer-aided diagnostic tools, is essential for disease cure and control. The chest radiography images, such as Computed Tomography (CT) and X-ray, and deep Convolutional Neural Networks (CNNs), can be a significant and useful material for designing such tools. However, designing such an automated tool is challenging as a massive number of manually annotated datasets are not publicly available yet, which is the core requirement of supervised learning systems. In this article, we propose a robust CNN-based network, called CVR-Net (Coronavirus Recognition Network), for the automatic recognition of the coronavirus from CT or X-ray images. The proposed end-to-end CVR-Net is a multi-scale-multi-encoder ensemble model, where we have aggregated the outputs from two different encoders and their different scales to obtain the final prediction probability. We train and test the proposed CVR-Net on three different datasets, where the images have collected from different open-source repositories. We compare our proposed CVR-Net with state-of-the-art methods, which are trained and tested on the same datasets. We split three datasets into five different tasks, where each task has a different number of classes, to evaluate the multi-tasking CVR-Net. Our model achieves an overall F1-score and accuracy of 0.997 and 0.998; 0.963 and 0.964; 0.816 and 0.820; 0.961 and 0.961; and 0.780 and 0.780, respectively, for task-1 to task-5. As the CVR-Net provides promising results on the small datasets, it can be an auspicious computer-aided diagnostic tool for the diagnosis of coronavirus to assist the clinical practitioners and radiologists. Our source codes and model are publicly available at GitHub
Title: covid-19 classification of x-ray images using deep neural networks
Journal: Eur Radiol
Published: 2021-05-31 (Journal Article, Peer reviewed (PubMed))
Condition: COVID-19
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: In the midst of the coronavirus disease 2019 (COVID-19) outbreak, chest X-ray (CXR) imaging is playing an important role in diagnosis and monitoring of patients with COVID-19. We propose a deep learning model for detection of COVID-19 from CXRs, as well as a tool for retrieving similar patients according to the model's results on their CXRs. For training and evaluating our model, we collected CXRs from inpatients hospitalized in four different hospitals. In this retrospective study, 1384 frontal CXRs, of COVID-19 confirmed patients imaged between March and August 2020, and 1024 matching CXRs of non-COVID patients imaged before the pandemic, were collected and used to build a deep learning classifier for detecting patients positive for COVID-19. The classifier consists of an ensemble of pre-trained deep neural networks (DNNS), specifically, ReNet34, ReNet50¸ ReNet152, and vgg16, and is enhanced by data augmentation and lung segmentation. We further implemented a nearest-neighbors algorithm that uses DNN-based image embeddings to retrieve the images most similar to a given image. Our model achieved accuracy of 90.3%, (95% CI: 86.3-93.7%) specificity of 90% (95% CI: 84.3-94%), and sensitivity of 90.5% (95% CI: 85-94%) on a test dataset comprising 15% of the original images. The AUC of the ROC curve is 0.96 (95% CI: 0.93-0.97). We provide deep learning models, trained and evaluated on CXRs that can assist medical efforts and reduce medical staff workload in handling COVID-19. A machine learning model was able to detect chest X-ray (CXR) images of patients tested positive for COVID-19 with accuracy and detection rate above 90%. A tool was created for finding existing CXR images with imaging characteristics most similar to a given CXR, according to the model's image embeddings.
Title: deep learning to estimate the physical proportion of infected region of lung for covid-19 pneumonia with ct image set
Published: 2020-06-08 (Preprint, arXiv)
Condition: COVID-19;Pneumonia
Task: 3. Monitoring/Severity assessment | Modality: CT

Abstract: Utilizing computed tomography (CT) images to quickly estimate the severity of cases with COVID-19 is one of the most straightforward and efficacious methods. Two tasks were studied in this present paper. One was to segment the mask of intact lung in case of pneumonia. Another was to generate the masks of regions infected by COVID-19. The masks of these two parts of images then were converted to corresponding volumes to calculate the physical proportion of infected region of lung. A total of 129 CT image set were herein collected and studied. The intrinsic Hounsfiled value of CT images was firstly utilized to generate the initial dirty version of labeled masks both for intact lung and infected regions. Then, the samples were carefully adjusted and improved by two professional radiologists to generate the final training set and test benchmark. Two deep learning models were evaluated: UNet and 2.5D UNet. For the segment of infected regions, a deep learning based classifier was followed to remove unrelated blur-edged regions that were wrongly segmented out such as air tube and blood vessel tissue etc. For the segmented masks of intact lung and infected regions, the best method could achieve 0.972 and 0.757 measure in mean Dice similarity coefficient on our test benchmark. As the overall proportion of infected region of lung, the final result showed 0.961 (Pearson's correlation coefficient) and 11.7% (mean absolute percent error). The instant proportion of infected regions of lung could be used as a visual evidence to assist clinical physician to determine the severity of the case. Furthermore, a quantified report of infected regions can help predict the prognosis for COVID-19 cases which were scanned periodically within the treatment cycle.
Title: dual-branch combination network (dcn): towards accurate diagnosis and lesion segmentation of covid-19 using ct images
Journal: Med Image Anal
Published: 2020-11-01 (Comparative Study;Journal Article;Research Support, Non-U.S. Gov't, Peer reviewed (PubMed))
Condition: COVID-19;Infections
Task: 2. Detection/Diagnosis | Modality: CT

Abstract: The recent global outbreak and spread of coronavirus disease (COVID-19) makes it an imperative to develop accurate and efficient diagnostic tools for the disease as medical resources are getting increasingly constrained. Artificial intelligence (AI)-aided tools have exhibited desirable potential; for example, chest computed tomography (CT) has been demonstrated to play a major role in the diagnosis and evaluation of COVID-19. However, developing a CT-based AI diagnostic system for the disease detection has faced considerable challenges, which is mainly due to the lack of adequate manually-delineated samples for training, as well as the requirement of sufficient sensitivity to subtle lesions in the early infection stages. In this study, we developed a dual-branch combination network (DCN) for COVID-19 diagnosis that can simultaneously achieve individual-level classification and lesion segmentation. To focus the classification branch more intensively on the lesion areas, a novel lesion attention module was developed to integrate the intermediate segmentation results. Furthermore, to manage the potential influence of different imaging parameters from individual facilities, a slice probability mapping method was proposed to learn the transformation from slice-level to individual-level classification. We conducted experiments on a large dataset of 1202 subjects from ten institutes in China. The results demonstrated that 1) the proposed DCN attained a classification accuracy of 96.74% on the internal dataset and 92.87% on the external validation dataset, thereby outperforming other models; 2) DCN obtained comparable performance with fewer samples and exhibited higher sensitivity, especially in subtle lesion detection; and 3) DCN provided good interpretability on the loci of infection compared to other deep models due to its classification guided by high-level semantic information. An online CT-based diagnostic platform for COVID-19 derived from our proposed framework is now available.
Title: covid faster r-cnn: a novel framework to diagnose novel coronavirus disease (covid-19) in x-ray images
Journal: Inform Med Unlocked
Published: 2020-08-25 (Journal Article, Peer reviewed (PubMed))
Condition: COVID-19
Task: 2. Detection/Diagnosis | Modality: X-Ray

Abstract: COVID-19 or novel coronavirus disease, which has already been declared as a worldwide pandemic, at first had an outbreak in a large city of China, named Wuhan. More than two hundred countries around the world have already been affected by this severe virus as it spreads by human interaction. Moreover, the symptoms of novel coronavirus are quite similar to the general seasonal flu. Screening of infected patients is considered as a critical step in the fight against COVID-19. As there are no distinctive COVID-19 positive case detection tools available, the need for supporting diagnostic tools has increased. Therefore, it is highly relevant to recognize positive cases as early as possible to avoid further spreading of this epidemic. However, there are several methods to detect COVID-19 positive patients, which are typically performed based on respiratory samples and among them, a critical approach for treatment is radiologic imaging or X-Ray imaging. Recent findings from X-Ray imaging techniques suggest that such images contain relevant information about the SARS-CoV-2 virus. Application of Deep Neural Network (DNN) techniques coupled with radiological imaging can be helpful in the accurate identification of this disease, and can also be supportive in overcoming the issue of a shortage of trained physicians in remote communities. In this article, we have introduced a VGG-16 (Visual Geometry Group, also called OxfordNet) Network-based Faster Regions with Convolutional Neural Networks (Faster R-CNN) framework to detect COVID-19 patients from chest X-Ray images using an available open-source dataset. Our proposed approach provides a classification accuracy of 97.36%, 97.65% of sensitivity, and a precision of 99.28%. Therefore, we believe this proposed method might be of assistance for health professionals to validate their initial assessment towards COVID-19 patients.