Table S3: Responses to Environmental exposure questionnaire for atopic participants. Environmental exposure questions Atopic Asthmatics (n = 42) Atopic (n = 21) p-value# Do you live within a mile of a farm? Yes No 17% 10% NS 83% 91% Do you live within a mile of a highway? Yes No 67% 48% 0.18 33% 52% Does the home you live in have a yard? Yes No 69% 57% NS 31% 43% Have you been around animals outside your home at least 2 days/week in the past 3 months? Yes No 36% 29% NS 64% 71% Are you frequently exposed (2 or more days/week) to tobacco smoke outside of your home? Yes No 17% 10% NS 83% 91% Has been any mold or mildew, on any surfaces inside your house in the past 12 months? Yes No 35% 35% NS 65% 65% Does your household have any pets? Yes No 33% 43% NS 67% 57% In general, and on a regular basis, are you exposed to cats? Yes No 29% 43% NS 71% 57% In general, and on a regular basis, are you exposed to dogs? Yes No 50% 43% NS 50% 57% In general, and on a regular basis, are you exposed to other furry pets? Yes No 7% 5% NS 93% 95% In general, and on a regular are you exposed to birds? Yes No 7% 5% NS 93% 95% In general, and on a regular are you exposed to farm animals? Yes No 5% 0% NS 95% 100% Do you ever see cockroaches in your Yes No 14% 19% NS 86% 81% Do you ever see rodents or rodent droppings in your Yes No 14% 19% NS 86% 81% Do you ever see cockroaches OR rodents/rodent droppings in your house? Yes No 29% 33% NS 71% 67% # Statistical significance was determined using Chi-square test, where NS = p≥0.2.
1925094 8.2 75.5 -67.4 Actinobacteria Actinobacteria Actinomycetales Micrococcaceae - - 260397 3.7 77.7 -74.0 Firmicutes Erysipelotrichi Erysipelotrichales Erysipelotrichaceae Allobaculum - 4372058 17.6 105.2 -87.6 0.026 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella melaninogenica 976838 7.3 98.5 -91.2 Proteobacteria Epsilonproteobacteria Campylobacterales Helicobacteraceae Flexispira - 4335578 221.3 313.5 -92.2 Firmicutes Clostridia Clostridiales Mogibacteriaceae - - 4459993 3.5 102.7 -99.1 0.0010 Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas - 495067 1.8 103.4 Actinobacteria Actinobacteria Actinomycetales Corynebacteriaceae Corynebacterium - 134265 1.0 119.2 Bacteroidetes Bacteroidia Bacteroidales Prevotellaceae Prevotella - 4306587 12.7 158.2 0.0156 Firmicutes Clostridia Clostridiales Veillonellaceae Selenomonas - 4400869 10.9 167.7 0.0960 SR1 - - - - - 891034 31.5 270.0 0.0806 Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Aggregatibacter - 4432431 91.3 963.7 0.0006 Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Aggregatibacter segnis # mean relative abundance
171954 93263 Amino Acid Metabolism Cysteine and methionine metabolism 231976 121154 110822 Amino Acid Metabolism Glycine, serine and threonine metabolism 54604 16710 37894 Amino Acid Metabolism Lysine degradation 268 46031 Amino Acid Metabolism Phenylalanine metabolism 159693 109911 Amino Acid Metabolism Phenylalanine, tyrosine and tryptophan biosynthesis 44 12 32 Amino Acid Metabolism Tryptophan metabolism 51684 20667 31017 Amino Acid Metabolism Tyrosine metabolism 317294 205019 112275 Amino Acid Metabolism Valine, leucine and isoleucine biosynthesis 276968 119360 157608 Amino Acid Metabolism Valine, leucine and isoleucine degradation 46198 546 45652 Biosynthesis of Other Secondary Metabolites Novobiocin biosynthesis 4388 18964 -14576 Biosynthesis of Other Secondary Metabolites Penicillin and cephalosporin biosynthesis 9285 -26946 Biosynthesis of Other Secondary Metabolites Phenylpropanoid biosynthesis 149876 160184 Carbohydrate Metabolism Amino sugar and nucleotide sugar metabolism 93433 4694 88739 Carbohydrate Metabolism Ascorbate and aldarate metabolism 413978 211294 202684 Carbohydrate Metabolism Butanoate metabolism