Column H. Fundamental purpose of project Project purpose cont animal health and welfare (Guinea pig; non-wild bred mouse, rat, rabbit; primate) production Column I. Benefit provided by project Project benefit cont Fundamental biology/physiology organs, tissues or cells from one species to another) Diseases-human Development of techniques- remedial, surgical, Diseases-animal diagnostic Diseases- zoonotic Education (demonstration) Environmental monitoring/ecology Training (student use of animals) Domestic animal management/production Regulatory product testing (e.g. vaccines, chemical, Wildlife management/conservation drug evaluation) Vertebrate pest management animals only Production of biological products (Guineapig, non-wild mouse, rat, rabbit; primate) Xenotransplantation (transplantation of living Specified Animal Breeding Colony Column J. Key particular procedures; if not relevant select ‘Other’ Procedure cont Attachment or insertion of devices for long term direct In vivo production of monoclonal antibody or telemetric monitoring In vivo production of polyclonal antibody Aversive stimuli for behavioural training, or for Ionising radiation exposure inducing a state of stress integral to the experiment Neuromuscular blocking agents or electro- Burning or scalding immobilisation Induction of disease model (e.g. diabetes, cardiac Ocular irritancy testing disease) Skin irritancy testing involving a chemical, or Gene manipulative technology cosmetic, household, or industrial preparation Immunomodulatory methods Toxicity testing Induction of infection Other procedure Induction of neoplasia animals only Interference with the central nervous system or sensory (Guineapig, non-wild mouse, rat, rabbit; primate) capacity or brain centres controlling that capacity Specified Animal Breeding Colony group
APPENDIX 3 - EXAMPLE OF A COMPLETED PART A, INCLUDING REPORTING OF SPECIFIED ANIMAL BREEDING STOCK In 2016 licence SPPL301 used mice and rats (specified animals), and fish in 2 AEC-approved projects (Projects 00061 and 00046). In addition, the licence bred mice and rats (specified animals) for use by the licence. The following table illustrates how the animal use procedures and the breeding of specified animals is to be described. The inclusion of ‘group numbers’ are illustrative only and should not be included in the submitted worksheet. A Year B Licence no. C Project or Specified Animal Breeding Colony D AEC project identification code E AEC date F Type of animal G Source H Purpose of animal use I Benefit focus of animal use J Particular procedure K Impact on animals L Total used M All deaths 1 2016 301 AEC-approved project 00061 Mice Own derivation Maintenance human health etc Diseases human Other procedure Animal unconscious without recovery 20 20 2 2016 301 AEC-approved project 00061 Rats Own derivation Maintenance human health etc Diseases Other procedure Animal unconscious without recovery 75 75 3 2016 301 AEC-approved project 00061 Rats Own derivation Maintenance human health etc Diseases human Other procedure Observational study etc 10 0 1 2016 301 AEC-approved project 00046 Fish Commercial supplier Understanding biology etc Fundamental biology etc Other procedure Animal unconscious without recovery 19 19 2 2016 301 AEC-approved project 00046 Fish Commercial supplier Understanding biology etc Fundamental biology etc Other procedure Minor Physiological challenge 5 0 3 2016 301 AEC-approved project 00046 Mice Own derivation Understanding biology etc Fundamental biology etc procedure Animal unconscious without recovery 5 5 1 2016 301 Specified Animal Breeding Colony SABC N/A Mice Own derivation Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony (non-GM) 5,235 293 2 2016 301 Specified Animal Breeding Colony SABC N/A Mice Own derivation Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony established GM line 1,987 183 3 2016 301 Specified Animal Breeding Colony SABC N/A Rats Own derivation Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony Specified Animal Breeding Colony established GM line 3,896 221