Clinical information Diagnosis: -Any mood disorder -Any anxiety disorder -Any personality disorder -Multiple diagnoses Risk Status: APS GRD -Duration of illness (years) -Medication exposure at baseline -PANSS General total Score -Drug Exposure during follow up Positive Symptoms CAARMS: -Disorder of Thought Content -Non bizarre Ideas -Perceptual Abnormalities -Disorganized Speech -Total Positive Score -Positive total score CAARMS: -Disorder of Thought Content -Non bizarre Ideas -Perceptual Abnormalities -Disorganized Speech -Total Positive Score -PANSS: -Positive total score CAARMS: -Disorder of Thought Content -Total Positive Score CAARMS: -Disorder of Thought Content Negative Symptoms CAARMS: -Avolition -Anhedonia -Alogia -Total Negative Score PANSS: -Negative total score CAARMS: -Avolition -Total Negative Score CAARMS: -Avolition Emotional Disturbances, CAARMS -Subjective Emotional Disturbances -Observed Blunted Affect -Observed None
Inappropriate Affect -Total Emotional Disturbances Cognitive Change, CAARMS -Subjective Experience -Observed Cognitive Change -Total Cognitive Change Score None Behavioral Change, CAARMS -Social Isolation -Impaired Role Functioning -Disorganized Odds Stigmatizing Behavior -Aggression Dangerous Behavior -Total Behavioral Change Score None Neurocognitive Performance, RBANS -Immediate Memory -Language -Visuospatial -Attention -Delayed Memory -Visuospatial -Attention -Visuospatial -Visuospatial Neurological Soft Signs, NES -Motor Coordination -Sensory Integration -Sequencing of complex motor acts -Others -Total NES Score -Sensory Integration -Sensory Integration -Sensory Integration Theory of Mind -Faux Pas -RMET -Th.o.m.a.s A -Th.o.m.a.s B -Th.o.m.a.s C -Th.o.m.a.s D -Faux Pas -Th.o.m.a.s A -Th.o.m.a.s B -Th.o.m.a.s C -Th.o.m.a.s D -Faux Pas -Th.o.m.a.s B -Faux Pas Baseline Functioning -GAF LSP-39: -Self Care -Non Turbulence -Social Contact -Communication -Responsibility -Total LSP-39 Score LSP-39: -Social Contact -Communication -Communication
eModel. Predictive model of psychosis transition in ARMS+ only (n=67) Predictor Variable β SE Wald X2 Hazard Ratio P Value AUCa (SE) [95% CI] R2N Sensitivity Specificity Avolition>3 (CAARMS) 1.340 0.52 6.66 3.82 0.010 Sensory Integration>2 (NES) 1.673 0.65 6.68 5.33 0.010 0.868 (0.060) [0.751-0.984] 0.495 0.765 0.920 Faux Pas<16 1.305 0.52 6.37 3.69 0.012 Positive predictive value (PPV): 81.25% ARMS+ only (n=67). Potential Predictor Domains and Individual Variables for the Cox Proportional Hazard Model “Transition to Psychosis”. Domain Variables Variables Retained after Univariable screening procedure for “Transition to Psychosis” (p<.10) Variables Retained After Multivariate Cox Regression Across Domains, Blockwise (p<.15) Final Model Demographics -Age at baseline -Education (years) -Gender -Employment None Clinical information Diagnosis: -Any mood disorder -Any anxiety disorder -Any personality disorder -Multiple diagnoses Risk Status: APS BLIPS GRD -Duration of illness (years) -Medication exposure at baseline Risk Status : BLIPS
-PANSS General total Score -Drug Exposure during follow up Positive Symptoms CAARMS: -Disorder of Thought Content -Non bizarre Ideas -Perceptual Abnormalities -Disorganized Speech -Total Positive Score -PANSS: -Positive total score None Negative Symptoms CAARMS: -Avolition -Anhedonia -Alogia -Total Negative Score PANSS: -Negative total score CAARMS: -Alogia -Avolition -Total Negative Score CAARMS: -Avolition -Avolition Emotional Disturbances, CAARMS -Subjective Emotional Disturbances -Observed Blunted Affect -Observed Inappropriate Affect -Total Emotional Disturbances -Subjective Emotional Disturbances -Observed Inappropriate Affect -Total Emotional Disturbances -Observed Inappropriate Affect Cognitive Change, CAARMS -Subjective Experience -Observed Cognitive Change -Total Cognitive Change Score None
eMatrix. Intercorrelations among measures included in the final models ap<0.01 bp<0.05 of Sensory abilities Faux Pas Disorder of Thought Content 0.246a 0.037 Sensory 0.246a -0.122 abilities 0.037 -0.122 References 1. Sauerbrei W, Schumacher M. A bootstrap resampling procedure for model building: application to the Cox regression model. Stat Med. 1992;11(16):2093-2109..