PI Institute for Transfusion Medicine Hemostasis and Vascular Biology Research Institute (admin core) $189,406 PI Hemophilia Center of Western PA Hemostasis and Vascular Biology Research Institute-Gladwin $136,423 PI Institute for Transfusion Medicine Genetic Basis of Differential Blood Donor RBC Storage Capacity/Polymorphisms that Improve Hemoglobin and/or storage iron in high intensity blood donors $31,099 Co-PI Bayer Corporation A Phase IIb Randomized, Placebo-Controlled Study to Assess the Safety, Tolerability, and Efficacy of Riociguat in Patients with Sickle Cell Diseases $5,730,790 Co-I NHLBI R01 HL079207 Reactive Oxygen Species in Vascular Disease $11,255 Co-I NHLBI 4 R37 HL058091 Effects of Nitric Oxide in Sickle Cell Blood $29,333 Co-I NHLBI U01 HL128954 Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC) $114,510 Co-I NIGMS Role of Erythroid DAMP Molecules in the Pathogenesis of Vascular Injury in Sepsis $154,570 Co-I NHLBI Novel Role of Smooth Muscle B5 Reductase in Sickle Cell Disease $386,805 Co-I United Therapeutics Corp. Effect of Remodulin in Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF) $183,270 COMPLETED GRANT SUPPORT PI Bayer Corporation Use of sGC Activators to Bypass NO Scavenging by Hemolysis in SCD $240,029 PI United Therapeutics Corp. Influence of Treprostenil on RV Function and Metabolism $80,283 Co-I Aires Pharmaceuticals A Dose Escalation Study to Evaluate the Effect of Inhaled Nitrite on $66,982 Blind,
Cardiopulmonary Hemodynamics in Subjects with Pulmonary Hypertension PI 07/01/16 – 06/30/17 DOD Four New Ideas to Protect Special Forces from the Stress of High Altitude $335.177 Co-I NIA Nitrite Benefits to Mediate Fatigability in Older HFpEF Patients $14,341 Co-I NHLBI R01 HL114795 RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells $244,111 PI NIH (NHLBI) 2T32 HL007563 Translational Training Program in Pulmonary Biology and Medicine (GRANT ACTIVE - PI CHANGED TO R. MALLAMPALLI IN 2015) $624,335 Co-I Bayer Corporation The Use of sGC Activators to Bypass Nitric Oxide Scavenging by Hemolysis in Sickle Cell Disease $270,000 Co-PI NHLBI 5 R01 HL096973-04 Myoglobin as a Nitrate Reductase that Regulates Hypoxic Cardiac NO Signaling $243,440 PI DOD W81XWH 11 2 0049 Small Molecule, Gas Based Therapies to Prevent Organ Injury from Trauma/Hemorrhage $12,692 Co-I NIH Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy $226,331 PI Children’s Hospital of Pittsburgh Phase II/III Trial of Sildenafil for Sickle Cell Disease Associate Pulmonary Hypertension-Clinical Sites $190,388 PI (NCE Pending) INO Therapeutics A Prospective Multicenter, Double Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalational in the Acute Treatment of Sickle Cell Plain Crisis $65,016 PI Henry M. Jackson Foundation/ ARMY Multifunctional Blood Substitute (MBS) for Field Resuscitation of Polytrauma Combat Casualties with Brain Injury and Concomitant Hemorrhagic Shock $57,138 Co-I NCRR UL1 RR024153 University of Pittsburgh Clinical and Translational Science Institute (CTSI) $244,189 Co-PI NIDDK 1 RC1 Dietary Nitrate Activation of PPARgamma Improves Insulin Sensitivity $329,763
December 10-13, 2005 – Plenary Session at the American Society of Hematology meeting in Atlanta, GA. Brain Natriuretic Peptide Identifies Pulmonary Hypertension as Major Risk for Death in MSH Trial in 1996 January 6-11, 2006 – 35th Critical Care Congress in San Francisco, CA March 23-25, 2006 – Society of French Hematology annual meeting in Paris, France April 1-6, 2006 – FASEB Meeting in San Francisco, CA April 4, 2006 – Grand Rounds at San Francisco General Hospital. San Francisco, CA April 6, 2006 – Grand Rounds at University of California, San Francisco, CA April 10-11, 2006 – Plenary Session, Roland Scott Lecture at the National Sickle Cell Disease Program annual meeting in Memphis, TN April 22, 2006 – Pharmacotherapy Frontiers 2006 Meeting at the NIH in Bethesda, MD May 19, 2006 – Cardiovascular Symposium at the University of Alabama at Birmingham, AL June 23, 2006 – Children’s Hospital Oakland Research Institute Symposium, Oakland, CA June 25-29, 2006 – Nitric Oxide Society Fourth International Conference on Biology, Chemistry and Therapeutic Applications of Nitric Oxide in Monterey CA September 18, 2006 – Grand Rounds at Johns Hopkins School of Medicine, Baltimore, MD October 7-10, 2006 – Europaediatrics 2006 Congress in Barcelona, Spain October 21-26, 2006 – American College of CHEST Physicians meeting in Salt Lake City, Utah November 14, 2006 – Functional Genomics Symposium, National Institutes of Health, Bethesda, MD November 17, 2006 – Medical Grand Rounds at Johns Hopkins School of Medicine, Baltimore, MD November 17, 2006 – Lung Research Seminar at Johns Hopkins School of Medicine, Baltimore, MD December 8, 2006 – Evolution of Pulmonary Hypertension: Emerging Diseases and Novel Therapeutics Meeting, NIH, Bethesda, MD February 4-9, 2007 – 7th Nitric Oxide Gordon Research Conference in Ventura Beach, CA March 30 – April 5, 2007 – Society for Experimental Biology Conference in Glasgow, Scotland