Supplemental Table 27. Summary of Outcomes Data Associated with ICU Delirium Multivariable analysis Univariable Analysis Variables Positive association Negative association No association Positive association Negative association No association Outcome variables: Discharge Disposition (discharge to other than home) *Balas CHEST 2009; 135, OR 7.2 (1.93-26.82), p .003 N = 114 [1] *Robinson Arch Surg 2011;146 39.1 vs 3.1%, p <.001, N = 172 [2] *Balas J Gerontol Nurs 2011; 37, OR 3.6 (0.7-17.76), p = .12, N = 43 *Mehta Crit Care Med 2015;43, 50 vs 46%, p = .34, N = 389 [3] Cognitive Impairment *Ely JAMA 2004; 291, HR 9.1 p .002 at hospital discharge [4] *Girard Crit Care Med 2010;38, at 3 and 12 months evaluating delirium duration. Point estimates = -4.6 and -6.9 with p = .02 and .03 respectively [5] *Pandharipande NEJM 2013;369. at 3 and 12 months evaluating delirium duration. See text *Wolters Crit Care 201418:R125. at 1 yr (self report) OR 2.41 and 3.1 for mild to moderate Guillamondegui J Trauma 2011;70 at 12 months Van den boogaard Crit Care Med 2012;40. at 18 months (self report), some aspects correlated with delirium and delirium duration, but others did not. See text. [7, 8]
impairment. P <.001 and .03 [6] PTSD *Jackson Lancet 2014 May at 3 and 12 months evaluating delirium duration [9] *Girard Crit Care 2007, 11R28 at 6 months evaluated with delirium duration [10] *Patel 2016 missed cut off but no relationship of PTSD and delirium duration AJRCCM [11] *Roberts. Crit Care 2007;18.[12] Depression *Jackson Lancet 2014 May at 12 months evaluating delirium duration. estimate 2.31 (1.25-4.27) p 0.05 [9] *Abraham Arch Phys Med Rehab 2014; 19 [13] *Jackson 2014 at 3 mon.evaluating delirium duration. 1.63 (.94-2.85) p .38 [9] Dependence/functionality May be overlap with disposition Usually measured by personal or instrumental ADLs or Barthel Index *Abelha Crit Care 2013, 17 for personal ADL at 6 mos, OR 2.2 [14] *Brummel Crit Care Med 2014; 42 for personal ADL at 12 months evaluating delirium duration, no point estimate offered but p = .002 [15] *Abelha Crit Care 2013, 17 for instrumental ADL at 6 mos, OR 0.8 (.4-1.6) [14] CHEST 2009; 135 at 1-2 d post discharge, OR 3.41 p .059 [1] *Brummel Crit Care Med 2014; 42 for *Yamaguchi Gen Hosp Psychiatry 2014;36. the need for social worker consultation at discharge as surrogate for dependence [17] *Balas J Gerontol Nurs 2011; 37 within 1 -2 days prior to hospital discharge, OR 2.44 (.49-12), p .27 [3] *Svenningsen J Clin Nurs 2014;23 at 1 wk, 3 and 6 months, “all p values nonsignificant” [18]
instrumental ADL at 12 months evaluating delirium duration, point estimate -.7 (-3.2-1.8) p .15 [15] *Jackson Lancet 2014 May at 3 and 12 months evaluating delirium duration [9] *Van den boogaard Crit Care Med 2012;40. using the SF 36 and checklist individual strength fatigue at 18 months. No relationship with delirium duration as well. *Norman 2016 missed cutoff, but did not find relationship between delirium duration and unemployment at 3 and 12 months [16] Distress Encompasses measurements of health status (SF36), health related quality of life (EQ5D), delusional or factual memories *Van den boogaard Crit Care Med 2012;40. using SF 36 at 18 months, duration of Svenningsen J Clin Nurs 2014;23 (more frequent delusional memories at 1 wk, Van Rompaey. J Clin Nurs 2009;18. SF 20 at 3 and 6 months [21] Roberts Crit Care 2007; at two years, less factual memories