zilongwang/ReadingBank huggingface dataset:
* F – relative bioavailability, CL – Clearance, V – Volume, ka – order absorption rate constant, NN – number of transit compartments, MTT – mean transit time, BSV – between subject variability, WSV – within subject variability
*Vmax – Maximum elimination rate for first order process, Km – drug concentration that results in half Vmax The median (interquartile of the pyrazinamide AUC0-24 and Cmax were 418 mg.h/L and 34 (29-39) mg/L respectively. Ethambutol One percent of the observations were the LLOQ of 0.1 mg/L. These missing observations were imputed to half of the LLOQ value, Beal’s M5 method (4). Minor modifications to a published model in a similar cohort of patients (2) revealed that an absorption model with an estimated 5 transit compartments, followed by first order elimination from a 1-compartment model adequately described the data. FOCE with ε-η interaction was the estimation algorithm employed. Clearance and volume were allometrically scaled for bodyweight. WSV in the absorption mean transit time, clearance and volume was included in the final model. BSV in clearance was also incorporated although BSV in other model parameters could not be supported by the data. A combined additive and proportional error model was used to describe the residual unexplained variability. The final model parameter estimates and RSE from the NONMEM covariance step are shown in supplementary table 4. Table S4: Ethambutol population pharmacokinetic model parameter estimates
Receiving Hormone Replacement Therapy (HRT) Women at moderately increased risk or greater should be encouraged to undergo yearly mammography from 40-50 years and yearly or biennial from 50 years. Women should be reminded that most breast cancer is unrelated to a positive family history and any breast changes should be reported and acted on. Young women with a moderately increased risk of breast cancer or greater should have an annual clinical breast examination with a breast-trained healthcare provider from 10 years younger than the age of onset for the youngest affected family member. Further discussion Further information concerning high risk factors is elaborated below: Gender: Females have a higher risk of developing breast cancer than males. The ratio of male to female breast cancers is 1: 135 Age: The risk increases with age. From 35 – 65 years there is a 6-fold increase in breast cancer. History of Neoplastic Disease of the Breast: Prior history of breast cancer carries an elevated risk of developing new primary breast cancer. The risk is 1% and 2% per year above the LTR at time of diagnosis, respectively for IDC and ILC. Lobular neoplasia (LN): LN, which includes atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) is associated with an increased risk of breast cancer: 3 – 4x with ALH and 8 – 10x with LCIS. A breast tissue biopsy showing proliferative disease with or without atypical cells results in an increased risk of developing breast cancer; the risk is higher with atypical ductal hyperplasia (ADH): RR 4 – 5 times. Family History: Family history of breast cancer is an independent risk factor. The risk is higher in women with breast cancer among young first degree relatives. A sister with breast cancer carries more risk than a mother. Carriers of BRCA1/ BRCA2 and other
medical device, packing or instruction for use only if this does not impair the visibility and legibility of the mark of conformity. Article 19 A medical device intended for clinical trials and a custom made device on the market must be accompanied by a statement from the manufacturer or an authorised representative of the manufacturer on the special purpose of the medical device in accordance with this Law and the regulations adopted for its implementation. A medical device intended for display at business fairs, exhibitions, presentations, etc. does not have to fulfil the conditions prescribed by this Law and the regulations adopted for its implementation, provided that a warning is indicated in a visible place that this medical device is not in compliance with the essential requirements and that its trade or use is forbidden for any purpose until it is in conformity with the essential requirements. The information necessary for the safe use of a medical device for the intended purpose, which is accompany medical device on the market or use in the Republic of Serbia, must be in Serbian and written in an understandable manner that takes into account the knowledge of the potential user, except the packaging of the medical device for professional use in accordance with this Law. When other regulations requiring the placing of the mark of conformity are applied to the medical device, this mark is evidence that this medical device meets the prescribed conditions. If one or more regulations allow the manufacturer to choose which solution to apply during a transitional period, the mark of conformity shall indicate that this medical device meets the provisions of only those regulations applied by the manufacturer. In this case, the manufacturer is obliged to document the detailed data contained in these regulations in the information or instructions for use required by these regulations and accompanying the medical device. 7. Incorrectly placed mark of conformity Article 20 If the Ministry determines that the mark of conformity has been placed unjustifiably or not placed at all, the manufacturer or authorised representative of the manufacturer or importer of a medical device that is not registered under Article 79 of this Law shall take appropriate corrective measures without delay. If the manufacturer or the authorised representative of the manufacturer or importer fail to take appropriate corrective measures in the case referred to in paragraph 1 of this Article, the Ministry shall limit or prohibit the placing on the market of that medical device, or take measures for its withdrawal in accordance with Article 21 of this law.
Coach assessment of Participant Name of _____________________________ Name of participant__________________________ Placement_______________________ Date_______________ Player strengths:
There are several opportunities for the caregiver to go wrong while undertaking these steps. Table 7 describes ORS preparation during behaviour trials and shows where participants made errors as they undertook each of the four above-described preparation steps. Only 4 of the 14 participants observed during ORS preparation made it correctly, mainly due to errors of measurement (correctly measuring 1 litre of water and measuring this water after the water had boiled) . Although this is a small sample, fewer errors were made by the rural participants, possibly due to more intensive health programmes working in the study area. A couple of participants in both George and Ngwerere mentioned people had come to their home in the past to explain how to make ORS. Table 7: ORS preparation in George and Ngwerere ID Clean water Measured OK Sachet correct Covered Prepared correctly GEORGE 1 Yes Yes Yes Yes Yes 2 Yes No No Yes No 3 Yes No No No No 4 No Yes Yes Yes? No 5 Yes No No ? No 6 Yes No Yes ? No 7 Yes No Yes ? No 8 Yes No Yes Yes No NGWERERE 1 Yes Yes? Yes Yes Yes? 2 Yes No Yes ? No 3 Yes Yes? Yes? Yes Yes 4 Yes No Yes Yes No 5 Yes Yes? No ? No 6 Yes Yes Yes Yes Yes The main issues associated with each stage of ORS preparation presented in table 7 and identified during observation and interview during the two follow-up visits, are described in turn below.
2. Data sources by intervention Public Sector Intervention Private Sector Intervention Additional Sources* A dedicated facility survey (baseline and follow-up) Administrative data, routinely reported through the HMIS and to MSL Exit interviews with patients A dedicated private facility survey (baseline and Audits, including use of ACT tracing through uniquely labeled packages Exit interviews with patients Mystery Shoppers Household Survey (baseline and follow up) Complementary Data (e.g. monthly weather statistics, community survey) Costing Data Note: * The additional sources will be used to (a) provide a comprehensive picture of health seeking behavior at the household level, (b) analyze the equity implications of each intervention, (c) control for potential confounders, and (d) measure the costs, relative costs and cost effectiveness of the proposed interventions. For more information on the contents of the data sources listed above and the motivation for collecting the datasets please see Annex 3. Please refer to Annex 2 for more details on sample selection and power calculations. 5. Resources 5.1 Task team The ESW team consists of Monique Vledder, Senior Health Specialist AFTH1 (TTL); Rosemary Sunkutu, Senior PHN Specialist AFTH1; Jed Friedman, Senior Economist DECRG (Principal Investigator); Prashant Yadav, Prof. in Supply Chain Management, MIT-Zaragoza; Mirja Sjöblom, Consultant AFTH1; and Edit Velenyi, Consultant DECRG. 5.2 Budget A preliminary estimate indicates the total cost for ZAAI will amount to approximately US$ 4.7 million for FY09 and FY10. For a more detailed budget see Table 3. Table 3. Preliminary Budget for the ZAAI Components Amount (in US$) Percent of total Public Sector Intervention 2,365,232 50% Private Sector Intervention 1,000,000 21% Impact Evaluation 1,365,800 29% TOTAL 4,731,032 DFID contributed with a US$3 million grant, which was provided through the External Funded Output (EFO) mechanism. USAID supports ZAAI with technical assistance and approximately US$900K for the public sector intervention. GRZ will contribute US$200K for the public sector training. The private sector intervention is primarily financed by the EFO from DFID. The impact evaluation has received funding in the amount of US$250K from the Spanish Trust Fund for Impact Evaluation and Results-based Management in Human Development Sectors (SIEF).
External shocks on a dollarized economy: an empirical evidence from Ecuador ERASMUS UNIVERSITY ROTTERDAM Erasmus School of Economics Department of Economics Supervisor: MSc Barbara Sadaba Name: Elena Cristina Zambrano Córdova Exam Number: 410474 E-mail address: ezambranoc@miradoreconomico.com
Now you get to choose, with your team, how you get to perform your poem with choosing vocal expression (different from your normal voice). Make a creative choice: change your pitch, volume, tempo or timbre/quality. You can say it together, each have your own line, or echo. Practice with your group and then we will share. Audience, how did the performers use their vocal expression? What did you learn about their habitat from their poem? What evidence do you have that they were collaborating? Criteria-based teacher checklist, peer assessment: Communicates ideas to others; makes compromises; and incorporates input/feedback. Makes a creative choice to express the poem: change pitch, volume, tempo or timbre/quality. _______________________________________________________________________ ARTS IMPACT LESSON PLAN Theater and Science Infused Lesson 2nd Grade: Salmon Habitat Power Poem ASSESSMENT WORKSHEET Disciplines SCIENCE SCIENCE THEATER SCIENCE THEATER Total 4 Concept Habitat Habitat Collaboration Vocal Expression Criteria Student Name Generates a list of words that describe the characteristics of the river streambed, estuary, and northern ocean. Free writes about the salmon habitat incorporating vocabulary. Chooses “purple words”, academic science vocabulary, and collaboratively constructs the poem. Communicates ideas to others; makes compromises; and incorporates input/feedback. Makes a creative choice to express the poem: change pitch, volume, tempo or timbre/quality. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18.
P admits during proceedings that K for sale was made received and accepted/paid for If UCC §2-201 is not satisfied, entire K is unenforceable Surety: K to guarantee the debt or duty of another. Goal is to provide a cautionary warning to suretor. Possible exception: when the primary purpose is to obtain an immediate and direct economic benefit or advantage for himself (CiN, pg 202) Other exceptions Security interests – sale or purchase does not need to be in writing Question 1: Did the Parties have a K? Does the law enforce all promises? NO K (R2K §1): A promise or a set of promises for the breach of which the law gives a remedy, or the performance of which the law in some way recognizes as a duty (§17) K = Mutual Assent + Consideration Mutual Assent: I agree, you agree of K Bilateral K: promise for a promise Unilateral K: promise for an act The act is the consideration “If you mow my law I’ll pay you $20” 1 party may never be bound. K isn’t triggered until party performs Express K Parties explicitly consent to the terms of the K Implied-in-Fact K True K, but party’s assent is implicit rather than explicit. Implied by the acts and manifestations of the parties. Remedies? Expectation, or reliance, or restitution. Just like a regular K. Implied-in-Law K (Quasi-K) Not a K, but label given to conduct that gives rise to liability for unjust enrichment. Remedies under quasi-K? Restitution. Unjust enrichment.
Meets Standard (Substantial compliance; complies in all material ways with the standard for the relevant review period) Does Not Meet Standard (Requires Corrective Action) Instructions for Overall Compliance Determination Narrative The narrative below must include a comprehensive discussion of all the evidence relied upon in making the compliance or non-compliance determination, the auditor’s analysis and reasoning, and the auditor’s conclusions. This discussion must also include corrective action recommendations where the facility does not meet the standard. These recommendations must be included in the Final Report, accompanied by information on specific corrective actions taken by the facility. SCREENING FOR RISK OF SEXUAL VICTIMIZATION AND ABUSIVENESS Standard 115.341: Screening for risk of victimization and abusiveness All Yes/No Questions Must Be Answered by the Auditor to Complete the Report 115.341 (a) Within 72 hours of the resident’s arrival at the facility, does the agency obtain and use information about each resident’s personal history and behavior to reduce risk of sexual abuse by or upon a resident? Yes No Does the agency also obtain this information periodically throughout a resident’s confinement? Yes No 115.341 (b) Are all PREA screening assessments conducted using an objective screening instrument? Yes No 115.341 (c)
Zarko Kostadinovski C/C++ Developer/Team Leader SUMMARY Zarko Kostadinovski is a skilful developer and team leader. He has more than 5 years of experience as a developer and more than 2 years as a team leader. He has great expertise in C, C++, Security and Embedded systems. He designed several software/hardware solutions for Embedded and Server environment. COMPUTER LANGUAGES OTHER SKILL HIGHLIGHTS (Max 5) Agile / Scrum methodology Performance & Memory Optimization Hardware security Openssl based security Organizational skills GET TO KNOW ZARKO Zarko Kostadinovski has 7 years of overall development experience working on large projects for big companies. He has experience working with C, C++, MySQL, Openssl, Linux and etc. He learned how to design and code complete software applications for high performance systems. Zarko knows how to work in a team, has excellent communication and analytical skills. He knows how to lead the team to achieve excellent results in reasonable time. EDUCATION M.S. in Embedded systems at the University of Macedonia Sept 2012 – June 2017 B.S. in Electronics and digital signal processing at the University of Macedonia Sept 2006 – June 2012 Courses: Android architecture (2011). Android system development (2011) Linux device drivers (2012) Security system design (2012) POS application development (2017) LANGUAGES Macedonian English ○ RECENT PROJECT EXPERIENCE 2014 – ECR design and implementation including hardware and embedded C++ application, Skopje, Macedonia 2015 – Security architecture based on hardware security for communication and data encryption, Istanbul, Turkey 2016 – Licensing solution design and implementation based on Smart Card, Skopje, Macedonia 2017 – Design and implementation of communication concentrator, Skopje, Macedonia
focusing on the quality and performance of local education system along with availability of local technology. Without a doubt, the role of government sees as equal important in this situation by providing balanced business eco-system including the info-structure and infrastructure support. The social element includes actively involved in social networking activities and trust’s capability among partners also see as important and encouraging for firm to collaborate. However, it depends on the clear defined and effective expectations between partners. Objective of collaboration Mean Std. Deviation (sd) Cumulative Percent (Slightly High Impact and above) To increase business opportunity (e.g. connection to market) 4.38 .763 89.70 Strengthen the position of your organisation in a competitive cluster of your business industry 4.27 .840 82.90 Improves and gain technical skills & know-how of selected technologies 4.26 .686 88.60 To develop new ideas (e.g. technology, design of product or process) 4.18 .687 88.40 To achieve profit maximisation 4.15 .851 77.30 Enjoy the tax benefit/credit from government (e.g. government support program to encourage collaboration) 3.99 .977 77.20 Increase social networking contact and reputation 3.87 .770 70.50 To increase social commitment and trust benefit with your collaborators 3.80 .805 69.30 To upgrade and increase the quality of R&D 3.77 .968 78.20 To achieve self-recognition and be known by others 3.74 .953 68.20 To increase the possibility of formatting new business venture (e.g. open your own company / start-up) 3.63 1.021 61.30 Government influence and policy that you have to collaborate with others (e.g. sometimes government has sign the memorandum of understanding (MoU) with other international firm to improve political relationship) 3.60 1.088 64.80 Ability to use collaborators patent e.g. licensing of patent 3.32 1.140 50.00
What expertise are on your team (e.g. engineering, math, statistics, computer science, clinical, industry) and who? Please list as “Expertise – Name, email” Engineering, biomechanics – Christopher Bertram, Mathematics – Charlie Macaskill, Lymphatic biology and physiology – David Zawieja, Lymphatic biology and physiology – Michael Lymphatic biology and physiology – Anatoliy Gashev, Lymphatic biology and physiology – Wei Wang, Physics, image segmentation – Igor Sazonov, Engineering, computational modeling – Raoul van Loon, *Save your abstract as “MSM PI Last Name _ 2018 IMAG Futures Pre-Meeting Abstract” Click to email your form to the NIBIB IMAG mailbox
Members Present: Patrice Scott (Chair), Butch Cushing (Vice Chair), Tom McGlauflin, David Kent, Stephanie Halter, Jack Scarborough Members Absent: Others Present: Brian Murphy, Land Use & Planning Director Call to Order and Roll Call: Patrice Scott opened the meeting at 7:00 PM and led in the pledge of allegiance. Roll call of the members was taken. Approval of Minutes: July 3, 2018: Butch Cushing made a motion to approve the minutes; seconded by David Kent. All in favor, Patrice Scott stated that case #1 and #3 would be reversed. PUBLIC HEARINGS 1. Case # 212-046SE10-02-18---A Request by Owner Mike McGinley (33 Sleeper Hill Rd, Gilford, NH) through his agent, Kevin French (French Land Services, LLC, Rumney, NH) for a Special Exception from Article IV: General Provisions, Section 401.1 – New Structures - to allow a two primary structures on a lot. The Ordinance allows this use in every Zone by Special Exception Direct Abutters have asked for letters of support to be read into the record. Kevin French presents the plans for this application. The parcel is to be developed in a cluster fashion. This allows for better development of the property. It will create more interworking of utilities, sidewalks and a more combined effort as far as parking. A proposed Market Basket is coming through the planning process. There will be signalized intersections in keeping with the types of uses already there. Building will be kept in the same type of style. Kevin shows renderings of what is proposed. They will keep the same character in the neighborhood. There is no nuisance or hazards and no burden to town services. It will be kept as a private site. It will meet all site plan requirements. It was noted that commercial developments as a whole don’t take many town services. They are asking that multiple commercial buildings be allowed on the same lot. Questions from the Board:
TOWN OF WASHINGTON Bryan Memorial Town Hall Post Office Box 383 Washington Depot, Connecticut 06794 ZONING BOARD OF APPEALS ******************************************************************************* COMMISSIONERS: IF YOU CANNOT ATTEND, PLEASE CALL THE LAND USE OFFICE AT 868-0423 PRIOR TO THE MEETING. THANK YOU. ******************************************************************************* AGENDA PUBLIC HEARING – REGULAR MEETING October 20, 2016 7:30 p.m. Main Level Meeting Room Call to Order Seating of the Members / Alternates Public Hearings with Deliberation to Follow: ZBA-1021: (Continued) Request of Douglas Hamilton/183 West Shore Road/Request for Variance from 11.6.1 Minimum Setback and Yard Dimensions and 12.1.1 Wetland and Watercourse Setbacks. HEARING – MEETING – VOTE ZBA-1022: Request of Anne Bowen/121 West Shore Road/Request for Special Exception for Non- Conforming Dwelling from Section 11.6.1 – Minimum Setback and Yard Dimensions. HEARING – MEETING – VOTE Consideration of Minutes of September 15, 2016 Other Business/Discretion of the Chair Adjournment _________________________________ Donna Pennell, Land Use Clerk October 4, 2016
Zoning Board of Appeals March 15, 2018 Chair Larry Fishman call meeting to order at 7:01PM Motion: John Kamp Second: Chris Dampman Pledge to the Flag Chair states the meeting is being recorded. Attendance: Larry Fishman – Chairman Chris Dampman John Kamp Code Enforcement Officer Dave Preston Board Secretary Monica McGill Absent: John Marciano Jim Donnelly Town Attorney Michael Davidoff Application 1-2018 Zachary Klein Hello, my name is Will Frank and this is my associate Stephanie, of Blusten, Shapiro, Rich, & Barone LLP, and we are the attorneys representing Mr. Zachary Klein. Larry Fishman: Why don’t you very briefly go over the application and summarize what you going to do. Mr. Frank: The situation is that Mr. Klein’s predecessor had built a treehouse on the property without a permit. And then there is the issue of a covered deck. So, we went to court. Larry Fishman: Are they both located on the same property. Mr. Frank: No, the treehouse is located on a separate property. So, Mr. Davidoff, the Building Inspector, and myself went to court to try and enter into a settlement. The agreement stated that my client would remove the treehouse within a certain period of time once the weather warmed up. After speaking with my client, he stated that a crew is scheduled to take the treehouse down on April 6, 2018. Larry Fishman: The treehouse is the one located on 55 Woods Road, correct? Mr. Frank: Yes. And the building inspector and I are still going back and forth on what to do with the covered deck. Being the covered deck is more important to our client, Mr. Davidoff suggested that we apply for a use variance, and that has brought us to this point.
2.1 Our Company- “Lighting Up Your 2.1.1 The Kenya Power & Lighting Company Limited (KPLC) is a limited liability company registered under the Companies Act, Chapter 486 of the Laws of Kenya. It was incorporated in 1922 as the East African Power & Lighting Company Limited. KPLC was listed on the Nairobi Stock Exchange (NSE) in 1954. The Company changed to its present name in 1983. 2.1.2 Our shareholders include the Government of Kenya (GoK), institutional investors and individual shareholders. KPLC is a public company with GoK holding the largest block of shares. We are subject to the State Corporations Act, Chapter 442 of the laws of Kenya and the laws governing procurement by public bodies, mainly the Public Procurement and Disposal Act, 2005 and the Regulations made thereunder. 2.1.3 Our Vision is “To provide world class power that delights our customers.” 2.1.4 Our Mission is “Powering people for better lives” 2.1.5 Our Core Business is to provide electrical energy and related customer services throughout Kenya. 2.1.6 Our Core Values were developed to support the Company’s purpose of powering the Nation to grow from our efforts. These include: - a) Customer First b) One Team c) Passion d) Integrity e) Excellence 3.3 Description of the Goods for Pre-qualification KPLC intends to pre-qualify Suppliers for Building and Civil works contractors. 3.2 Eligibility for Pre-Qualification 3.2.1 This Invitation to Prequalify is open to all Candidates eligible as described in the Appendix to Instructions to Candidates.
Main Brushes Move Brush (B + M + V) Clay Buildup – change alpha channel to influence shape (B + C + B) Dam Standard (Bb + D + S) Brush Settings (Spacebar) Zbrush Demo Trial: https://pixologic.com/zbrush/trial/ Setting Up 1.1 Exporting an OBJ from Maya Select your mesh, then go to File > Export Selection (Options) File type: OBJExport If OBJExport is not in those options, go to Windows > Settings/Preferences > Plug-in Manager Make sure objExport.mll is loaded 1.2 Open Zbrush and import your Under Tool: Import Left-click and drag to put the mesh in the scene Press ‘T’ to make the object sculptable If you accidentally create a of duplicate meshes, press ‘Control + N’ to clear the viewport
Passion Project Proposal Directions: Once you have decided which of your passions you are going to focus on for your passion project, you need to submit to your teacher a proposal in which you explain a number of things about the project you’ll be undertaking. It should answer any questions that we have about your Passion Project, though if necessary, we may discuss your proposal. Passion: 1. What will be your area of (Topic) 2. What MAIN question are you trying to answer through your research? 3. What real problem/situation is your idea connected to? 4. Why did you choose this particular Passion? Resources: 5. What sources will you use to research your passion? Who, or what, will help you to accomplish this project, and how do you think they, or it, will help you meet your goal. ( Use a primary source for information if possible. Talk to or contact an expert in the field) Initial Plan: ____________________________________________________________________________
---------------------------- August 2016 Sun Mon Tue Wed Thu Fri Sat 1 Flotilla 31-9 meeting 2 3 4 5 6 OPEX Lake Perry 7 8 9 Flotilla 31-2 meeting 10 11 12 13 14 Back to School Fair (Maple Hill)? 13th? 15 16 17 18 19 20 21 22 23 24 25 26 27 LOA Shoot Out 28 LOA Out 29 30 31 August 2016
---------------------------- September 2016 Sun Mon Tue Wed Thu Fri Sat 1 2 3 COMO Cup 4 COMO Cup 5 6 7 8 9 10 11 12 Flotilla 31-9 meeting 13 Flotilla 31-2 meeting 14 15 16 17 18 19 20 21 22 23 Dist. Board Mtg. 24 Dist. Board Mtg. 25 26 27 28 29 30 September 2016
Mendel gene allele trait P, F1, F2 Griffith Avery, MacLeod, & McCarty Hershey and Chase Meselson & Stahl proteinase 35S 32P bacteriophage semi-conservative conservative dispersive E. coli Nitrogen-14 Nitrogen-15 heavy vs light CsCl gradient Beadle & Tatum auxotroph prototroph metabolic pathway Neurospora crassa Chargaff’s Rules Watson and Crick DNA bases sugar-phosphate backbone anti-parallel complementary hydrogen bond groove groove adenine cytosine thymine guanine Central Dogma transcription reverse transcription translation RNA prion one-gene:one-enzyme minimal medium complete medium arginine genetic screen nuclear genome c-value paradox model organism Saccharomyces cerevisiae Caenorhabditis elegans Drosophila melanogaster Mus musculus rerio Arabidopsis thaliana Escherichia coli ______________________________________________ 1.1 How would the results of the cross in Figure 1.have been different if heredity worked through blending inheritance rather than particulate inheritance? 1.2 Imagine that astronauts provide you with living samples of multicellular organisms discovered on another planet. organisms reproduce with a short generation time, but nothing else is known about their genetics. a) How could you define laws of heredity for these organisms? b) How could you determine what molecules within these organisms contained genetic information? c) Would the mechanisms of genetic inheritance likely be similar for all organisms from this planet? d) Would the mechanisms of genetic inheritance likely be similar to organisms from earth? 1.3 It is relatively easy to extract DNA and protein from biochemists had been doing this since at least the 1800’s. Why then did Hershey and Chase need to use radioactivity to label DNA and proteins in their experiments?
hemizygous wild-type variant locus genotype phenotype dominant recessive complete dominance incomplete (semi) dominance co-dominance ABO blood group haplosufficiency haploinsufficiency classical genetics molecular genetics true breeding lines monohybrid cross Punnett Square test cross tester sex-linked dosage compensation X-linked genes autosomal genes reciprocal cross Z-linked hermaphrodites parthenogenesis hormonal cell-autonomous sexual sexually dimorphic gynandromorphy mosaic chimera G + E = P penetrance expressivity sampling effects chi-square χ2 test 3.1 What is the maximum number of alleles for a locus in a normal gamete of a diploid species? 3.2 Wirey hair (W) is dominant to smooth hair (w) in dogs. a) If you cross a homozygous, dog with a smooth-haired dog, what will be the genotype and phenotype of the F1 generation? b) If two dogs from the F1 generation mated, what would be the most likely ratio of hair phenotypes among their progeny? c) When two wirey-haired Ww dogs actually mated, they had alitter of three puppies, which all had smooth hair. How do you explain this observation? d) Someone left a wirey-haired dog on your doorstep. Without extracting DNA, what be the easiest way to determine the genotype of this dog? e) Based on the information provided in question 1, can you tell which, if either, of the alleles is wild-type? 3.3 An important part of Mendel’s experiments was the use of homozygous lines as parents for his crosses. How did he know they were homozygous, and why was the use of the lines important? 3.4 Does segregation of alleles into daughter cells happen during mitosis, meiosis, or both? 3.5 If your blood type is B, what are the possible genotypes of your parents at the locus that controls the ABO blood types? 3.6 In the table below, match the mouse hair color phenotypes with the term from the list that best explains the observed phenotype, given the genotypes shown. In this case, the allele symbols do not imply anything about the dominance relationships
Transposable elements are dynamic, abundant components of eukaryotic genomes and important forces in evolution. Transposable elements are dynamic, abundant components of eukaryotic genomes and important forces in evolution. The efficiency of mutant screening is limited by silent mutations, redundancy, and embyronic lethality. Mutation of different genes can produce a similar phenotype. Complementation testing determines whether two mutants are the result of mutation of the same gene (allelic mutations), or if each mutant is caused by mutation of a different gene (non-allelic mutations). mutation mutant polymorphism insertion deletion substitution mutagen DNA replication error Strand slippage biological mutagen chemical mutagen physical mutagen mispairing loop SSR insertional mutagen Class I, Class II transposon retrotransposon reverse transcriptase transposase non-autonomous autonomous SINE, LINE, Alu P-element T-DNA cut-and-paste alkylation agent EMS intercalating benzopyrene carcinogenic ethidium bromide thymine dimer mutant screen loss-of-function gain-of-function amorph null hypomorph hypermorph neopmorph dominant negative somatic cells germline cells silent mutation inter-genic region redundancy essential gene recessive lethal allele complementation testing allelic / non-allelic cM0, M1, M2 redundancy lethality allelic non-allelic complementation group CFTR Cystic Fibrosis (CF) F508(PHE508DEL) Kalydeco ______________________________________________________________________________________
Because recombination frequency is usually proportional to the distance between loci, recombination frequencies can be used to create genetic maps. Recombination frequencies tend to underestimate map distances, especially over long distances, double crossovers may be genetically indistinguishable from non-recombinants. Three-point crosses can be used to determine the order and map distance between of three loci, and can correct for some of the double crossovers between the two outer loci. linkage recombination independent assortment crossover recombinant genotype parental genotype unlinked recombination frequency (RF) complete (absolute) linkage incomplete (partial) linkage syntenic synapsis coupling (cis) configuration repulsion(trans) configuration repulsion map units (mu) centiMorgans (cM) genetic map conserved synteny double-crossover three-point cross 7.1 Compare recombination and crossover. How are these similar? How are they different? 7.2 Explain why it usually necessary to start with pure-breeding lines when measuring genetic linkage by the methods presented in this chapter. 7.3 If you knew that a that affected earlobe shape was tightly linked to a locus that affected susceptibility to cardiovascular disease human, under what circumstances would this information be clinically useful? 7.4 In a previous chapter, we said a 9:3:3:1 phenotypic ratio was expected among the progeny of a dihybrid cross, in absence of gene interaction. a) What does this ratio assume about the linkage between the two loci in the dihybrid cross? b) What ratio would be expected if the loci were completely linked? Be sure to consider every possible configuration of alleles in the dihybrids. 7.5 Given a dihybrid with the genotype CcEe: a) If the alleles are in coupling (cis) configuration, what will be the genotypes of the parental and recombinant progeny from a test cross? b) If the alleles are in repulsion (trans) configuration, what will be the genotypes of the parental and recombinant progeny from a test cross?
fur (A) tail (B) behaviour (C) AB AC BC white short normal 16 aBC R R P brown short agitated 0 ABc P R R brown short normal 955 ABC P P P white agitated 36 aBc R P R white long normal 0 abC P R R brown long agitated 14 Abc R R P brown long normal 46 AbC R P R white long agitated 933 abc P P P B-C 4.1% AB AC BC 16 16 0 0 0 0 0 0 0 36 0 36 0 0 0 14 14 0 46 0 46 0 0 0 112 30 82 5.6% 1.5% 4.1%
GEM COUNTY OIL & GAS OPERATIONS ORDINANCE (for a public hearing before the Board of County Commissioners on May 2, 2016 at 6:30 pm at the Gem County Courthouse) OIL AND GAS OPERATIONS Gem County Code Amendment – Title 11 (New Chapter) NOW, THEREFORE, BE IT ORDAINED AS FOLLOWS: SECTION 1. PURPOSE. The purpose of this ordinance is to provide, through zoning provisions, for the reasonable use of land for oil and gas drilling while providing health, safety and general welfare protections for Gem County residents. Idaho State rules mandate the allowance of oil and gas drilling, but allow counties local permitting rights and regulations. Accordingly, it is necessary and appropriate to adopt this ordinance for oil and gas resource development so that these resources can be obtained in a manner that is economically beneficial for all stakeholders and to minimize the adverse impacts on the residents of Gem County. Local governments are preempted from regulating the same features of oil and gas well operations or accomplishing the same purposes regulated under Idaho Statute 47-317. Local zoning regulates surface land use as authorized under the Local Land Use Planning Act (I.C. 67-65). SECTION 2. ADOPTION OF NEW CHAPTER ## TO ZONING ORDINANCE. The Gem County Zoning Ordinance is hereby amended to add the following new Chapter: SECTION 3. DEFINITIONS. For the purposes of this Chapter, the following definitions shall apply unless the context clearly indicates or requires a different meaning. Administrative: A regulatory review and/or action performed by an employee or contractor of Gem County and not deemed a legislative or quasi-judicial action. Applicant: That person, corporation, or other legal entity possessing the legal right to develop the mineral resource or any other use proposed in connection thereof for the
ZULULAND DISTRICT MUNICIPALITY Hereby invites quotation for: Quotation no: ZDMQ 1441 Zululand District Municipality would like to invite the interested suppliers to submit quotation for the ZDM School Uniform and Bursary event 2013, on 17 January 2012 @ Edumbe. Suppliers are required to submit quotation for the following: CATERING FOR 5000 PEOPLE: MENU: Rice, Chicken or Beef Curry, 1 Veggie, 1 Salad, 250ml Juice. (NB: CATERERS TO PROVIDER SHELTER FOR DISHING UP PURPOSES) Please note that prospective suppliers are to submit anCERTIFIED COPY BY THE SAPS OF TAX CLEARANCE, BEE CERTIFICATE AND CK FOUNDATION STATEMENT AND DECLARATION FORMS with their quotation. ONLY BONA FIDE CATERING COMPANIES (COMPANIES RUNNING DAILY CATERING BUSINESS) WILL BE GIVEN PREFERENCE. For enquiries please contact Sthembile Mthembu at 035 874 5614 during office hours. Quotation documents are available from office no G7. CLOSING DATE: 14 January 2013 @ 12HOO. Duly completed quotation documents sealed in an envelope marked with the quotation number and the closing date are to posted into the tender box at Zululand District Municipality, Lot Gagane Street, Ulundi, 3838 by no later than 12H00 on the closing date. Telegraphic, email, telefaxed or posted tender will not be accepted. The Bid committee of Zululand District Munic Zululand District Municipality would like to invite the interested suppliers to submit quotation for the ZDM School Uniform and Bursary event 2013, on 17 January 2012 @ Edumbe. Suppliers are required to submit quotation for the following: ipality does not bind itself to accept the lowest or any quotation, or to furnish any reason for the acceptance or rejection of a quotation. JH De Klerk Municipal Manager
Zechariah 3 (3:1) שָׂטָן = “adversary, Satan” under BDB 966a. Arm שְׂטָנָא סְטָנָא. Arb šaṭana “be remote” (especially from truth and mercy of God). שׂטן = (denominative) “be or act as adversary” under BDB 966b. Rare. (3:2) יהוה גער = “rebuke” under BDB 172a. Arm גְעַר. Sab יגער PN. אוּד = “brand, fire-brand” under BDB 15b. Very rare. Root אוד = “be curved, bent burden, oppress”. נצל = Hophal “plucked <- snatched away, delivered” under BDB 664a. Arb naṣala “tincturam exuit emisitque”(???). (3:3) לבשׁ = “put on (a garment), wear, clothe, be clothed” under BDB 527b. Arm לְבֵישׁ . Akk labāšu. Arb labisa. צֹאִי = “filthy” under BDB 844a. Only Zechariah 3. Root צוא = “be foul, polluted”. (3:4) ויאמר... עונךָ – Text critical note = “a few(? manuscripts?) transpose after verse 5”. והלבשׁ אתךָ – Text critical note = “Septuagint has equivalent of ‘and you will dress him’”. מַחֲלָצָה = “robe of state” (taken off in ordinary life) under BDB 323a. Only here and Isaiah 3:22. Root חלץ = “draw off or out, withdraw”.
(3:5) ואמר ישׂימו צָנִיף = “turban” under BDB 857a. Rare. Root צנף = “wrap, wind up, together”. טָהוֹר = “clean, pure” under BDB 373a. Root טהר = “be clean, pure”. (3:6) עוד = (denominative) “testify, bear witness” under BDB 729b. (3:7) מִשְׁמֶרֶת = “guard, watch, charge, function” under BDB 1038a. דין = under BDB 192a. Arb dāna “to be obedient, submissive, requite, compensate, rule, govern”. Akk dānu “judge”. Arm דִין. חָצֵר = “enclosure, court” (m and more often f) under BDB 346b. Root חצר = “encompass, surround, enclose”. מַהֲלָךְ = “walk, journey, going (late)” under BDB 237a. Here “goings (free access)”. (3:8) מוֹפֵת = “wonder, sign, portent” under BDB 68b. Root אפת = “calamity, wonder, portent”. המה צֶמַח = “sprout, growth” under BDB 855b. Root צמח = “sprout, spring up”. (3:9)
פתח II = Piel “engrave” under BDB 836a. Akk patāḫu “bore, penetrate”. פִתּוּחַ = “engraving” under BDB 836b. Rare. מושׁ מישׁ = “depart, remove”, Hiphil “remove, take away” under BDB 559a. (3:10) גֶפֶן = “vine” under BDB 172a. Arb jafnu(n) (Yemen). Akk gapnu. Arm גוֹפַן. תְאֵנָה = “fig-tree, fig” under BDB 1061a. Arb ti(y)nu(n). Arm תֵינְתָא. Pun? תין. Akk tittu “a tree”.
ZULULAND DISTRICT MUNICIPALITY Hereby invites quotation for: Quotation no: ZDMQ: 66/09/2013 (Re-Advertisement) Zululand District Municipality would like to invite the interested supplier to submit quotation for the Road show 29 September 2013 Durban. Suppliers are required to submit quotation for the following: Hiring of 40 Buses DURBAN CENTRAL (Bus Routes) 1 Bus – Mayville,1 Bus – ward 72, 1Bus – Dalton/ Thokoza/ ward 33, 1 Bus – ward 31 Pick up point – Botha OUTER WEST Bus – ward 5 /6 &7, 2 Buses – ward 91, 1 Bus – Molweni, 1 Bus – Mkhizwana, 1 Bus- kwaNyuswa ( ward 3), 1 Taxi (ward 8) Pick up B.P Garage, Hammarsdale INNER WEST 1 Bus – ward 16/17, 1 Bus – ward 19/22/23 and ward 92, 1 Bus – ward 12/13 &15 Pick up point- Civic Centre NORTH 1 Bus – Osindisweni, 1 Bus – Waterloo, La Mercy, Ocean Drive Inn, 1 Bus –Magwaveni, Newtown, Hambanathi 1 Bus – Staram, Gwala’s Farm, Indluyomlilo Pick up point – Tongaat Rank SOUTH 1 Bus - ward 67, 1 Bus – ward 89, 1 Bus – ward 94, 1 Bus- ward 95,1 Bus – ward 99 Pick up point – Isipingo Metro Police NORTH CENTRAL 6 Buses – Lindelani (ward 38/43/45),1 Bus – ward 11, 1 Bus – ward 34, 1 Bus – ward 37, 1 Bus – ward 42 1 Bus – ward 53, 1 Bus – ward 41, 1 Bus – ward 3/56, 1 Bus – ward 57, 1 Bus – ward 46/47, 1 Bus – ward 48/49/52 1 Bus – ward 102 Pick up kwaMashu Station SOUTH CENTRAL 1 Bus – M &R, 1 Bus – E,F& G, 1 Bus – Lamontville& Jacobs, 1 Bus – Malukazi&Engonyameni, 1 Bus – ward 85/87 Pick up point- Umlazi Mega City Road worthy certificate per each Bus Drivers with valid driver’s licence and PDP Driver with sober habits
Figure 5  Mount the four riders onto the optical bench and fit the lens and polarization filter, étalon support table, interference filter, and CCD camera onto the riders as shown in Figure 4.  Position the riders on the bench with the support rods at approximately the following separations: of magnet yoke base – lens/polarizing filter: 15 cm Lens/polarizing filter - interference filter: 6 cm (as close as possible) Interference filter – étalon support table: 10 cm Étalon support - CCD camera – 15 cm  Make sure that the lens in the lens/polarization filter combination faces the magnet.  Filter has been changed. Turn either way Ignore this:The interference filter appears when viewed from one side and yellow when viewed form the other.  Carefully adjust the heights of the lens/polarization filter, interference filter, and CCD camera so that their centers are aligned with the center of the mercury lamp and clamp them in place. Fix the adjusted heights with the positioning rings on the support rods (see Figure 6). This allows the optical elements to be easily removed and replaced accurately.  As a rough guide for initial positioning, when the optical axes of the various elements are collinear and aligned with the lamp center, the bottoms of the positioning rings are at the following distances below the bottoms of their respective elements: Lens/polarizing filter: 95 mm Interference filter: 97 mm Étalon table: 34 mm CCD camera: 98 mm  Figure 6  Place the Fabry-Pérot étalon on the support table, oriented with the three plate adjusting screws on the lamp side and the single tilt adjustment screw on the camera side. Make sure the étalon is centered on the optical axis and square to it. Do not adjust the plate adjustment screws.  6. Optimizing the Interference Pattern The procedure for determining e/m involves measuring the diameters of concentric circles which differ only slightly. Precise adjustment of the optical setup to yield properly centered and undistorted circular fringes is important for obtaining an accurate result. To obtain a good interference pattern, attention should be paid to the following factors:  Even illumination of the Fabry-Pérot étalon.  Careful positioning of the various optical elements so they are centered along the optical axis of the setup and e
Lección 5-Las vacaciones H –LAS VACACIONES (Lección 5) – Select word corresponds to the picture. 5 TOTAL EX: Ans: hacer surf I – LAS VACACIONES (Lección 5) – Select the word that is being described. 5 TOTAL EX: es la persona que el equipaje a la habitación de un hotel. Ans: el botones J– EL TIEMPO- (Lección 5) – Select which weather phrase describes the picture. 5 total EX: Ans: hace sol
WHAT CENSUS RECORDS TELL US ABOUT JEWISH FAMILIES OF 19th CENTURY , A CASE STUDY: THE SHTETL ZEIMELIS 1816-1853 By Anatolij Chayesh, St.Petersburg Translated by Sonia Kovitz GOALS OF THE STUDY To and analyze information about the Jews of the shtetl Zheymeli (the current city of , ) contained in the 7th, 8th & 9th revision lists (census records). To demonstrate the benefits of studying the census records of an entire Jewish community rather than solely of individual families. To provide insight into the original archival census records prior to their reconfiguration into the digitized data files available on JewishGen.com. TRANSLATOR’S NOTE: The English term “census” may either to the activity of taking a census or to the record of gathered information. The Russian term PEREPIS’ [перепись – perepis’], usually translated as “census,” as in English may refer either to the activity or the record. Russian also has a pair of historical terms that distinguish between the activity and the record: REVISION and REVISION LIST. This set of terms applies only to the censuses of the 17th –early 19th century. REVISION [ревизия – revizia] is the activity of taking a census, i.e., a periodic collection of information carried out region by region, family by family, individual by individual. REVISION LIST [ревизкая cказка – revizkaya skazka] is the record of the information gathered during the REVISION. Russian census records of the 17th – early 19th century, namely REVISION LISTS, were published in a chronological sequence of editions. Accordingly, the 7th, 8th & 9th REVISION LISTS are the records of the 7th, 8th & 9th REVISIONS. “List” in this context refers specifically to the Russian term SKAZKA [cказка], whose literal meaning is “story.” SKAZKI (plural) are records containing detailed commentary on individual subjects of the Tsar. Copies of records from the lists may be obtained from the . HISTORICAL BACKGROUND A broad review of censuses in is not our task. Neither the censuses of the Grand Duchy of Lithuania nor the First General Census [perepis’] of the Russian Empire taken in 1897, nor