/ PY 1. 105 1 _ 15 35 PY 1. 106 2 _ 30 70 3 PY 1. 107 _ 25 50 6 PY 1. 108 Pharmaceutical Chemistry-I _ 4 25 50 6 PY 1. 109 _ 4 25 50 6 PY 1. 110 _ 6 25 50 6 PY 1. 111 _ 2 15 35 3 PY 1. 112 _ 4 25 50 6 13 18 / 24 305 PY 1. 104 Mathematics I for Intermediate Biology Students .
(50 Minutes) SIO- NAL PY 4. 201 4 _ 30 70 3 PY 4. 202 & 6 _ 30 70 3 PY 4. 203 2 _ 25 50 2 PY 4. 204 4 _ 30 70 3 & I - A
Based on Theory PHYSICAL PHARMACY - I PY.1.112 Period / Week: 2 Sessional: 15 Duration of Exam: 3 hrs Examination: 35 Nature of Exam: Practical Based on Theory ORGANIC CHEMISTRY - II PY.2.101 Period / Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory This will be in continuation of the organic chemistry – I course. Following the usual style, emphasis will be placed on the following. UNIT – I Arommaticity, Electrophilic aromatic substitution, Arenes and their derivatives, elements of spectroscopy and structure, cerbanions, Nucleophilic aromatic substitution. UNIT – II Preparation and reaction of amines and phenols, conjugate and addition; polynuclear aromatic hydrocarbons. UNIT – III Heterocyclic compounds: system of numbering and naming of heterocyclics commonly encountered in therapeutic agents. Structure, synthesis and reactions of pyrrole, furan, thoiphene, pyridine, quinoline and isoquinoline. UNIT – IV Acquaintance with the following heterocyclic ring systems with suitable examples of medicinally important compounds, pyridine, benzopyran, pyrazole, isoxazole, thiazole, pyridazine, pyrimidine and phenothiazine.
UNIT – IV COORDINATE GEOMETRY: - Co – ordinate axes and quadrants, distance between two points the formula and area of a triangle, equations of a straight lines parallel to the co – ordinate axes. Definition of a conic section, standard equations to parabola, hyperbola and ellipse, simple examples (using direction and focus property) UNIT – V STATISTICS: Standard deviation, theory of probability, Histogramme, Standard t – test, cauchy-square test, Analysis of variance, Regression analysis, Co–efficient of correction, Curve fitting. Text Book: Higher Engineering Mathematics by Grawal – 1991 24th Edn., Text Book of Mathematics by N. Krishna moorthy. Chand series, Volume - I ANATOMY, PHYSIOLOGY AND HEALTH EDUCATION PY.2.103 Period / Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Introduction to the anatomical terms in relation to parts of The body, systems and organs, elementary knowledge of the human skeleton. Tissues of the body: properties and functions of epithelial, connective, muscular, nervous and osseous (bone) tissues. General principles of membrane permeability, diffusion, transport membrane potentials, action potentials.
Annual report. Safe use of Medicines. Professional practices. Current state of Hospital Pharmacy in India. Text Books: Hospital Pharmacy-Hassan. Cooper and Gunn’s Dispensing for Pharmaceutical student-carter. 25th Edition, 1987. Reference Dispensing of Medication – Martin. Pharmaceutical Arithmetic and and Srivastava. Clinical Pharmacy-Jenkins, Superandio and Italiclasis. PHARMACEUTICAL ENGINEERING – I PY.2. 203 Period / Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Materials for pharmaceutical plant construction; Factors affecting the material selection for pharmaceutical plants. Ferrous metals cast iron, steels, stainless steels, Nonferrous metals—copper, aluminum, lead, tin, silver, nickel, zinc platinum, chromium and their important alloys, Nonmetals – glass, stoneware, stone state, bring, concrete, asbestos, rubber, timber, plastics. Corrosion and its prevention: Types of corrosion, factors influencing corrosion, theories of corrosion, methods of prevention of corrosion.
TEXT BOOKS: Mechine drawing – N. D. Bhatt. REFERENCE BOOKS: Manual of Engineering Drawing for students and draftsmen – French and Vierck. Technical drawing – Giesecke, Mitchell and Spencer. PHARMACOGNOSY – I PY.2. 208 Period / Week: 6 Sessional: 25 Duration of Exam: 6 hrs Examination: 50 Nature of Exam: Practical Determination of leaf constants such as stomatal index, stomatal number, vein-islet number, vein termination number and palisade ratio. Measurement of starch grains, dimensions of calcium oxalate crystals and phloem fibres. Study of fibres and animal drugs as referred to in theory. Identification of plant constituents like carbohydrates, lipids, proteins, alkaloids, glycosides, volatile oils, tannins, resins and resin-combinations; Evaluation of phytochemicals by paper and thin layer chromatography. Detemination of ash values, moisture content, extractive values, swelling factor and foreign organic matter. PHARMACEUTICAL CHEMISTRY – II (Natural Products) PY.3.101 Period / Week: 4 Sessional: 30 Duration of Exam: 3 hrs
Examination: 70 Nature of Exam: Theory UNIT – I: Carbothdrates : Classification and general properties, study of the constitution of glucoss, fructose and maltose. UNIT – II: Oils and fats: Chemistry and analysis according to pharmacopeial methods. Terpenes : Occurrence, General methods of isclation and classification; constitution of cirtral, menthol and camphor. UNIT – III: Amino acids and proteins; Classification and general reactions of amino acids and their relationship to proteins and polypeptides, protein hormones, oxytocics, thyroid hormones and anti – thyroid drugs. UNIT – IV: Alkaloids: Classification, General methods of extraction and structure elucidation, constitution of ephedrine, atropine, papaverine and quinine. Purine and xanthine Derivatives : Caffeine, Theophylline, Theobromine and uric acid. Nucleic acids: General aspects. UNIT – V: Chemistry of steriod Drugs : Nomenclature, sterols, methods of isolation, colour reactions of cholesterol, stigmasterol, ergosterol, Important bile acids; Diosgenin and hecogenin, steroid alakaloids, Estrogens and Progestational agents – contraceptive steroids; androgens and anabolic agents, Adreno contraceptive steroids; Androgens and anabolic agents, Adreno corticoids, Deoxycoorticosterone, Cortisone, Prednisone, Aldosterone, Cardiac Glycosides of Digitalis and other Cardiac drugs – Strophanthus and Squill. TEXT BOOKS: I. L. Finar, Organic Chemistry, Vol. II The English Language Book Society, London. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry R. F Doerge, Ed., J. B. Lippcncott Company, Philadelphia. REFERENCE BOOKS: R. T. Morrison and R. N. Boyd, Organic Chemistry, Allyn and Bacon, Ine., Boston. Burger’s Medicinal Chemistry, M. E. – Wolff, Ed., John Wiley & Sons, New york.
properties of colloids, solubilization gels – structure, properties and applications. Micromatics: Particle size and size distribution – average particle size, particle size distribution, number and weight distributions, particle number; methods for determining particle size – optical microscopy, sieving, sedimentation, particle volume measurement, particle shape and surface area, methods for determining surface area – absorption methods, air permeability methods; derived properties of powders – porosity, packing arrangements, densities bulkiness, flow properties. UNIT – V Rheology: Newtonian systems – laws of flow, kinetic viscosity, effect of temperature. Non newtonian systems – plastic, pseudoplastic dilatant flow, thixotropy – measutement of thixotropy, thixotropy in formulation. Determination of rheologic properties – choice of viscometer, capillary, falling sphere, cup and bob, and cone and plate viscometers. Psychorheology. Applications to pharmacy. Coarse dispersions, emulsions and semisolids. Interfacial properties of suspended particles p settling in suspensions – theory of sedimentaion, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters. Formulation of suspensions – wetting of particles, controlled flocculation, theological considerations, preparation of suspensions. Emulsions – types, pharmaceutical applications, theories, physical stability, preservation, and theological properties. Semisolidsgels. TEXT BOOKS: Physical Pharmacy – Martin, A. & others. REFERENCE BOOKS Tutorial Pharmacy – Cooper & Gunn.
R.E.Schrimer, Modern methods of Pharmaceutical Analysis CRC Press. J.W.Robinson, Undergraduate Instrumental analysis. Marcel Dekker, Inc., New York Chromatography, D.R. Browning. Mcgraw Hill, London. Pharmaceutical Chemistry L.G. Chatten Ed., Marcel Dekker Inc., New York PHARMACEUTICS – III (Dosage formulations & design) PY . 4 . 103 Period/week: 4 Sessional : 30 Duration of Exam : 3 hrs Examination : 70 Nature of Exam : Theory UNIT – I Dosage form necessities: Antioxidants, Preservatives, colouring, flavouring and diluting agents, solvents and vehicles, their properties & selection. Surfactants, hydrocolloids, stabilizers. UNIT – II Formulation: Importance, physical properties – physical form particle size – crystal form. Bulk control solubility. Wet flow – cohesiveness – compressibility – organoleptic properties, chemical properties – hydrolysis – oxidation, racemization, polymerization, isomerization, and decarboxylations, enzymic decomposition; ( formulation excipients – destabilizers, suspending and dispersing agents – dyes – excipients.) UNIT – III Stability of formulated products – requirements, product stability, shelf life, overage, containers, closures. Kinetic principles and stability testing – Reaction rate and order, acid – base catalysis, decomposition reactions, stabilization and stability testing. UNIT – IV Prolonged action pharmaceuticals – benefits, limitations; oral products, terminology, drug elimination rate, types and construction of product, evaluation, parenteral products and evaluation.
Experiments devised to study the formulation of dosage forms, stability testing; formulated dosage forms – evaluation of dosage forms; preparation and evaluation of prolonged action and dosage forms. PHARMACOLOGY – II PY . 4 . 107 Period/week: 4 Sessional : 30 Duration of Exam : 3 hrs Examination : 70 Nature of Exam : Practical Experiments based on theory. Drug – interaction studies. PHARMACEUTICAL CHEMISTRY – IV (Medicinal Chemistry – II) PY . 4 . 201 Period / week: 4 Sessional : 30 Duration of Exam : 3 hrs Examination : 70 Nature of Exam : Theory An outline of Synthetic procedures (of selected drugs of each category, from IP) uses, structure – activity relationships including physico chemical and steric aspects, Metabolism and mode of action of the following classes of drugs. UNIT – I Adrenergic drugs, cholinergics and anticholinesterases: Antispasmodics and antiulcer ganglionic blocking agents. UNIT – II General Anesthetics, local anesthetics; diagnostic agents, gsastrointestinal agents. UNIT III Analgesics, antipyretis; non-steroidal antiinflammatory agents; antiallergenic agents. UNIT IV Hypnotics and sedatives; anticonvulsants; analeptics.
UNIT – II Bioavailability and bioequuivalence – definitions – significance – factors involved – Assessment – bioequivalence testing – legal consideration – Dissolution rate – Methods, Apparatus, significance. UNIT – III Drug disposition – Distribution – Localisation of drugs – Metabolism and elimination of drugs – Renal clearance – Factors, Kinetics. UNIT – IV Pharmacokinetics; Introduction-Basic concepts – Rate processes in biological systems – pharmacokinetic parameters-biological volume of distribution, clearance, absorption rate constant – Methods of determination – significance and applications. UNIT – V Compartment models – basic concepts – one and two compartment models – Kinetics of blood levels – pharmacokinetics of absorption, distribution, metabolism and elimination under the following conditions; i) intravenous bolus injection. ii) Intravenous infusion .iii) oral – single dose and iv) oral – multiple dose. TEXT BOOKS Biopharmaceutics and Pharmacokinetics – An Introduction by Robert E. Notari, 2nd edn. 1975, Marcel Dekkar Inc., New York. The theory and practice of Industrial Pharmacy By leon Lachman, 2nd edn, 1985 and 3rd edn. 1987, Warghese publishing Bombay. REFERENCE BOOKS Remingtons Pharmaceutical sciences 17th edn. 1985 Mac Publishing Co., Easton, Pennsylvania. Modern Pharmaceutics by Banker, 1979, Marcel Dekker Inc., New York.
PHARMACEUTICAL CHEMISTRY – IV(Medicinal Chemistry – II) PY . 4 . 205 Period/week: 6 Sessional: 25 Duration of Exam: 6 hrs Examination: 50 Nature of Exam: Practical Determination of physical constants and performance of chemical tests as prescribed in the pharmacopoeia of India. Analysis of tablets, Injections and other pharmaceutical preparations. Synthesis of a few selected drugs from different categories included in Medicinal Chemistry I & II. BIOPHARMACEUTICS AND PHARMACOKINETICS PY . 4 . 206 Period/week: 4 Sessional : 25 Duration of Exam : 6 hrs Examination: 50 Nature of Exam: Practical Experiments on Biopharmaceutics and Pharmacokinetics. COSMETICOLOGY PY . 4 . 207 Period/week: 4 Sessional : 25 Duration of Exam : 6 hrs Examination: 50 Nature of Exam: Practical Preparation of various cosmetics studied in theory.