OF CONTENTS FULL PUBLIC REPORT 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 5 3. COMPOSITION 5 4. INTRODUCTION AND USE INFORMATION 5 5. PROCESS AND RELEASE INFORMATION 6 5.1. Distribution, Transport and Storage 6 5.2. Operation Description 6 5.3. Occupational exposure 6 5.4. Release 7 5.5. Disposal 7 5.6. Public exposure 7 6. PHYSICAL AND CHEMICAL PROPERTIES 7 7. TOXICOLOGICAL INVESTIGATIONS 9 7.1. toxicity – oral 10 7.2. Acute toxicity – dermal 10 7.3. Acute toxicity – inhalation 11 7.4. Irritation – skin 11 7.5. Irritation – eye 11 7.6. Skin sensitisation 12 7.7. Repeat dose toxicity 12 7.8. Genotoxicity – bacteria 13 7.9. Genotoxicity – in vitro 14 7.10. Genotoxicity – in vivo 15 8. ENVIRONMENT 15 8.1. Environmental fate 15 8.1.1. biodegradability 15 8.1.2. Bioaccumulation 15 8.2. Environmental Effects 16 8.2.1. Acute toxicity to fish 16 8.2.2. Acute/chronic toxicity to aquatic invertebrates 16 8.2.3. Algal growth inhibition test 17 8.2.4. Inhibition of microbial activity 17 9. RISK ASSESSMENT 18 9.1. Environment 18 9.1.1. Environment – exposure assessment 18 9.1.2. Environment – effects assessment 18 9.1.3. Environment – risk characterisation 18 9.2. Human health 18 9.2.1. Occupational health and safety – exposure assessment 18 9.2.2. Public health – exposure assessment 18 9.2.3. Human health - effects assessment 19 9.2.4. Occupational health and safety – risk characterisation 19 9.2.5. Public health – risk characterisation 19 10. CONCLUSIONS – ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND HUMANS 19 10.1. Hazard classification 19 10.2. Environmental risk assessment 19 10.3. Human health risk assessment 20 10.3.1. Occupational health and safety 20 10.3.2. Public health 20 11. MATERIAL SAFETY DATA 20 11.1. Material Safety Data Sheet 20 11.2. Label 20 12. RECOMMENDATIONS 20 12.1. Secondary notification 21 13. BIBLIOGRAPHY 21
OECD TG 201 Alga, Growth Inhibition Test. Species Scenedesmus suspicatus Exposure Period 72 hours Concentration Range Nominal 100 mg/L (Filtered) Water Hardness 24 mg Analytical Monitoring Test solutions were not measured Algae were exposed to the filtrate of a super saturated stock suspension of the notified chemical at a nominal concentration of 100 mg/L under constant illumination and shaking. After 72 h, there was no significant inhibition of algal growth or biomass at the nominal concentration of 100 mg/L. The ecotoxicity data indicates the notified chemical is not toxic to algae up to the limit of its solubility. IBACON GmbH, Germany (1999k) 8.2.4. Inhibition of microbial activity Urea 1 OECD TG 209 Activated Sludge, Respiration Inhibition Test. Inoculum Activated sludge Exposure Period 3 Concentration Range Nominal 10, 32, 100, 320, 1000 mg/L The activated sludge study was conducted using sludge obtained from sewage treatment plant in Groβ-Zimmern, Germany. The definitive study was conducted on nominal concentrations of 10, 32, 100, 320 and 1000 mg/L. Amounts of test material (5, 16, 50, 160 and 500 mg) were added to water (284 mL) and sewerage (16 mL) and samples were stirred continuously. The reference material used in the study was When compared to the control, activated sludge after 3 h experienced differences in respiration of between –6.6 to 5.7%. The EC50 for the notified substance to activated sludge could not be quantified. However, the 3-hour EC50 for the notified substance to activated sludge is expected to be greater than 1000 mg/L. The EC50 of the reference substance was 9 mg/L, therefore confirming the suitability of the activated sludge. EC50 > 1000 mg/L NOEC Not determined The ecotoxicity data indicates the notified chemical is not toxic to activated sludge up to 1000 mg/L suspension. IBACON GmbH, Germany 9. RISK ASSESSMENT 9.1. Environment 9.1.1. Environment – exposure assessment The new chemical will be used as a component of a ready-to-use grease at one mining site in Western Australia. The majority of the import volume will be collected and disposed of by