zilongwang/ReadingBank huggingface dataset:
Following two range finding tests, a definitive test was conducted at with concentrations 0.464 – 21.50 mg/L under static conditions for a period of 96 h. Test conditions were: 20-21°C, pH 7.3 – 7.7, 8.0 – 8.7 O2 mg/L, 8 hours dark and 16 hours light period. The LC50 was calculated using probit analysis. Mortality Nominal Concentration mg/L Number of Fish 1 h 4 h 24 h 48 h 72 h 96 h Control 10 0 0 0 0 0 0 0.464 10 0 0 0 0 0 0 1.000 10 0 0 0 0 0 0 2.150 10 0 0 0 0 0 0 4.640 10 0 0 0 0 0 0 10.00 10 0 0 10 10 10 10 21.50 10 0 0 10 10 10 10 LC50 4.6 – 10 mg/L at 96 hours (based on nominal concentrations) NOEC 4.64 mg/L at 96 hours (based on nominal concentrations) Remarks – Results No undissolved test substance was observed and no abnormalities were observed in live fish. The test substance is toxic to fish BASF (1989) A.2.2. toxicity to aquatic invertebrates The analogue chemical (purity ca. 90%) Guideline for testing of chemicals EG-1 of Jan 1982 (EPA Office of Substances) - Static Species Daphnia magna Exposure Period 48 hours Auxiliary Solvent dimethylsulfoxide Water Hardness 2.6 mmol/L Analytical Monitoring None reported Remarks - Method Only a summary report was provided. The test substance and dimethylsulfoxide (dispersing agent) were added to the dilution water at 50 and 100 mg/L respectively. The stock suspension was stirred for 17 hours at 25°C. Serial dilution was used to prepare the test solutions. A definitive test was conducted with test substance concentration 0.098 – 3.13 mg/L. Test conditions were: 19.8°C, pH 7.9–8.2, 7.5–9.0 mg O2/L, 8 hours dark and 16 hours light period. The EC50 after 48 hours was determined by the Spearman-Karber method. Number Immobilised
the amount of chemical being introduced has increased from 1,500 tonnes per annum, or is likely to increase, significantly; the chemical has begun to be manufactured in ; additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health, or the environment. The Director will then decide whether a reassessment (i.e. a secondary notification and assessment) is required. No additional secondary notification conditions are stipulated. Material Safety Data Sheet The MSDS of a product containing the notified chemical provided by the notifier was reviewed by NICNAS. The accuracy of the information on the MSDS remains the responsibility of the applicant. ASSESSMENT DETAILS APPLICANT AND NOTIFICATION DETAILS Nalco Australia Pty Ltd (ABN 41 000 424 788) BOTANY, NSW 2019 Standard: Chemical other than polymer (more than 1 tonne per year). 75 Data items and details claimed exempt from publication: chemical name, CAS number, molecular and structural formulae, molecular weight, analytical data, degree of purity, impurities, additives/adjuvants, use details, import volume and identity of manufacturer/recipients. 24 Variation to the schedule of data requirements is claimed as follows: vapour pressure, hydrolysis as a function of pH, partition co-efficient, absorption/desorption, dissociation constant, explosive properties, acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, skin irritation, eye irritation, skin sensitisation, repeated dose toxicity, induction of point mutations, induction of germ cell damage, ready biodegradation and bioaccumulation. None (current) IDENTITY OF CHEMICAL PETROSTEP S-2 (contains 20 – 30% notified chemical) PETROSTEP S-2 HA (contains 35 – 45% notified chemical) < 500 Da Reference NMR spectra were provided. COMPOSITION 77 – 99%
C9H15ClN2S2 250.816 Da Reference HPLC spectra were provided. COMPOSITION Approximately 60% Chemical Name Carbonimidodithioic acid, methylene dipropyl ester CAS No. 58585-54-9 Weight % 9 Hazardous Properties Irritant (information provided by the notifier) Chemical Name Carbonimidodithioic acid, cyano-, dihexyl ester CAS No. 56342-27-9 Weight % 16 Hazardous Properties Irritant (information provided by the notifier) Chemical Name Carbonimidodithioic acid, bromomethyl hexyl ester CAS No. Unassigned Weight % < 6 Hazardous Properties Unknown (>1% Chemical Name Polymeric by-product CAS No. Unassigned Weight % 15 None PHYSICAL AND PROPERTIES Appearance at 20 ºC and 101.3 kPa: orange liquid Property Value Data Source/Justification Freezing Point < -5oC Measured Boiling Point > 100oC (pressure unknown) MSDS for CHED Density 1100 kg/m3 at 25oC Measured Vapour Pressure 2.74 × 10-6 kPa at 25oC Estimated (Modified Grain EPA ) Water Solubility 5.6 × 10-3 g/L at 25oC Measured Hydrolysis as a Function of pH t ½ = 159 h (pH 5 at ~25oC) t ½ = 135 h (pH 7 at ~25oC) Measured
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS SUBSTANCE INTRODUCTION VOLUME USE STD/1405 Marubeni Australia Ltd Phosphoric acid compound in ADK STAB FP-2200 Yes ≤70 tonnes per annum Flame retardant in polymeric resins CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available data the notified chemical is classified as hazardous according to the Approved Criteria for Classifying Hazardous Substances [NOHSC:1008(2004)]. The classification and labelling details are: R36 Irritating to eyes and The classification of the notified chemical using the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS) (United Nations 2009) is presented below. This system is not mandated in and carries no legal status but is presented for information purposes. Hazard category Hazard statement Eye irritation Category 2A Irritating to eyes Aquatic Environment Category 3 Harmful to aquatic life Chronic Category 3 Harmful to aquatic life with long lasting effects Human health risk assessment Under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the limited aquatic exposure and the assessed use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Hazard Classification and Labelling Safe Work Australia, should consider the following health hazard classification for the notified chemical: Xi R36 Irritating to eyes Use the following risk phrases for products/mixtures containing the notified chemical:
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS SUBSTANCE INTRODUCTION VOLUME USE STD/1406 Marubeni Australia Ltd T-1063FM Yes ≤120 tonnes per annum Flame retardant in polymeric resins CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available data the notified chemical is classified as hazardous according to the Approved Criteria for Classifying Hazardous Substances [NOHSC:1008(2004)]. The classification and labelling details are: R36 Irritating to eyes and The classification of the notified chemical using the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS) (United Nations 2009) is presented below. This system is not mandated in and carries no legal status but is presented for information purposes. Hazard category Hazard statement Eye irritation Category 2A Irritating to eyes Aquatic Environment Acute Category 3 Harmful to aquatic life Chronic Category 3 Harmful to aquatic life with long lasting effects Human health risk assessment Under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of limited aquatic exposure and the assessed use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Hazard Classification and Labelling Safe Work Australia, should consider the following health hazard classification for the notified chemical: Xi R36 Irritating to eyes Use the following risk phrases for products/mixtures containing the notified chemical:
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS SUBSTANCE INTRODUCTION VOLUME USE STD/1423 Prysmian Telecom Cables & Systems Australia Pty Ltd The J Vlaeminck Family Trust Chemical in Cablelite 9D9-464 Yes ≤ 200 tonnes per annum Coating component for cables CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available information, the notified chemical is recommended for hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia. The recommended hazard classification is presented in the table below. Hazard classification Hazard statement Skin Irritation (Category 2) H315 – Causes skin irritation Skin Sensitisation (Category 1) H317 – May cause an allergic skin reaction Based on the available information, the notified chemical is recommended for hazard classification according to the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004) with the following risk phrase: Xi: R43 May cause sensitisation by skin contact Xi: R38 Irritating to skin The environmental hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS) is presented below. Environmental classification under the GHS is not mandated in Australia and carries no legal status but is presented for information purposes. Hazard category Hazard statement Aquatic Environment Acute 3 Chronic 3 Harmful to aquatic life Harmful to aquatic life with long lasting effects Human health risk assessment Under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the assessed use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Hazard Classification and Labelling The notified chemical should be classified as follows: Skin Irritation (Category 2): H315 – Causes skin irritation
TABLE OF CONTENTS FULL PUBLIC REPORT 4 1. APPLICANT AND NOTIFICATION DETAILS 4 2. IDENTITY OF CHEMICAL 4 3. COMPOSITION 5 4. INTRODUCTION AND USE INFORMATION 5 5. PROCESS AND RELEASE INFORMATION 5 5.1. Distribution, transport and storage 5 5.2. Operation description 5 5.3. Occupational exposure 6 Exposure Details 6 5.4. Release 7 5.5. Disposal 7 5.6. Public exposure 7 6. PHYSICAL AND CHEMICAL PROPERTIES 8 7. TOXICOLOGICAL INVESTIGATIONS 10 7.1. Acute toxicity – oral 10 7.2. toxicity – dermal 11 7.3. Acute toxicity – inhalation 11 7.4. Irritation – skin 11 7.5. Irritation – eye 12 7.6. Skin sensitisation 13 7.7. Repeat dose toxicity 14 7.8. Genotoxicity – bacteria 15 7.9. Genotoxicity – in 16 7.10. Genotoxicity – in vivo 17 8. ENVIRONMENT 18 8.1. Environmental fate 18 8.1.1. Ready biodegradability 18 8.1.2. Bioaccumulation 19 8.2. Ecotoxicological investigations 19 8.2.1. toxicity to fish 19 8.2.2. toxicity to aquatic invertebrates 20 8.2.3. growth inhibition test 20 8.2.4. Inhibition of microbial activity 21 9. RISK ASSESSMENT 21 9.1. Environment 21 9.1.1. Environment – exposure assessment 21 9.1.2. Environment – effects assessment 22 9.1.3. Environment – risk characterisation 22 9.2. Human health 22 9.2.1. Occupational health and safety – exposure assessment 22 Transport, Warehouse and Storage 23 Processing 23 9.2.2. Public health – exposure assessment 24 9.2.3. health – effects assessment 24 9.2.4. Occupational health and safety – risk characterisation 25 9.2.5. Public health – risk characterisation 25 10. CONCLUSIONS – ASSESSMENT LEVEL OF CONCERN FOR THE ENVIRONMENT AND HUMANS 26 10.1. Hazard classification 26 10.2. Environmental risk assessment 26 10.3. Human health risk assessment 26 10.3.1. Occupational health and safety 26 10.3.2. Public health 26 11. MATERIAL SAFETY DATA SHEET 26 11.1. Material Safety Data Sheet 26 11.2. Label 26 12. RECOMMENDATIONS 27
FULL PUBLIC REPORT Levafix Red CA 1. APPLICANT AND NOTIFICATION DETAILS Dyechem Industries Pty Ltd (ABN: 76 055 025 879) 60-62 Road West Heidelberg Victoria 3081 Standard: Chemical other than polymer (more than 1 tonne per year). 75 Data items and details claimed exempt from publication: Chemical names(s) Other name(s) CAS number Molecular formulae Structural formula Molecular weight Spectral data Purity Identity of toxic or hazardous impurities % Weight of toxic or hazardous impurities Non-hazardous impurities Import volume 24 Variation to the schedule of data requirements is claimed as follows: Particle Size Flash Point Flammability Limits Reactivity Acute Inhalation Toxicity Genotoxicity - Induction of Germ Cell Damage Bioaccumulation No European (1998) Canada (1999) China (1998) United States (1998) 2. IDENTITY OF CHEMICAL Levafix Red CA
Irritation – skin Notified Chemical OECD TG 404 Acute Dermal Irritation/Corrosion. EC Directive 2004/73/EC B.4 Acute Toxicity (Skin Irritation). Species/Strain Rabbit/New White Number of Animals 3 males Vehicle None Observation Period 72 h Type of Dressing Semi-occlusive. Remarks - Method No significant protocol deviations. One animal was treated initially, and two animals were treated 14 days later. The observation period for the two animals treated later was 72 h. Remarks - Results No irritation, corrosion, staining or systemic toxicity was observed in the animals during the test period. No mortality occurred during the test period. The table of individual skin irritation scores was not provided. The notified chemical is non-irritating to the skin. NOTOX (2004c) Irritation – eye Notified Chemical OECD TG 405 Acute Eye Irritation/Corrosion. EC Directive 2004/73/EC B.5 Acute Toxicity (Eye Irritation). Species/Strain Rabbit/New White Number of Animals 3 males Observation Period 72 h Remarks - Method No protocol deviations were reported. One animal was treated initially, and a further two animals five days later. Observations were terminated after 72 h. Lesion Mean Score* Animal No. Maximum Value Maximum Duration of Any Effect Maximum at End of Observation Period 1 2 3 Conjunctiva: redness 0.33 1 0.33 2 48 h 0 Conjunctiva: chemosis 0 0 0.33 2 24 h 0 Conjunctiva: discharge 0.33 0.33 0.33 1 24 h 0 Corneal opacity 0 0 0 0 - 0 Iridial inflammation 0 0 0 1 1 h 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results No evidence of corrosion, staining or systemic toxicity was observed during the test period. No mortality occurred during the test period. The notified chemical is slightlyirritating to the eye. NOTOX (2004d) Skin sensitisation – mouse local lymph node assay (LLNA)
CORRIGENDUM – issued November 2015 Public report for STD/1435 Page 11, in Section 6.2 “Human Health Effects Assessment”, under the subsection “Observations on Human Exposure”, make the following changes: * First sentence – replace “9 volunteers” with “50(49) volunteers” * Third sentence – change the beginning of the sentence from “A larger scale repeated insult patch test” to “Another repeated insult patch test” Page 20, In “Section B8 – Skin Sensitisation – Volunteers”, make the following changes: * Induction procedure – replace “9 volunteers” with “50(49) volunteers” * Induction procedure – replace “applications of 48 hours” to “applications at intervals of about 48 hours” * Rest period – replace “15 weeks” by “15 days” * Challenge procedure – replace “50 volunteers” with “50(49) volunteers” * Challenge procedure – remove duplicated phrase “in each application”
The positive controls caused statistically significant increases in the proportion of aberrant cells, demonstrating the validity of the test system. The notified chemical was not mutagenic to bacteria under the conditions of the test. LEMI (2010) Genotoxicity – in vitro Analogue 3 In vitro Mammalian Cytogenetics Assay. Remarks No study details were provided in the summary. The test substance was negative with and without activation, in vitro, under the conditions of the test. USEPA (2005)
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS INTRODUCTION VOLUME USE STD/1439 STD/1440 Qenos Pty Ltd STD/1439: Component of XCAT VP-100 Catalyst STD/1440: Component of XCAT VP-110 Catalyst Yes STD/1439: ≤10 tonnes per STD/1440: ≤10 tonnes per annum Catalysts for polyethylene production CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available information, the notified chemicals are recommended for hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia. The recommended hazard classification is presented in the table below. Hazard classification Hazard statement Pyrophoric Solids (Category 1) H250 – Catches fire spontaneously if exposed to air Substances and mixtures in contact with water, emit flammable gases (Category 1) H260 – In contact with releases flammable gases, which may ignite spontaneously Acute Toxicity (Category 4) H302 – Harmful if swallowed Skin Corrosion (Category 1) H314 – Causes severe skin burns and eye damage In Australia, additional non-GHS hazard statements apply (see Guidance on the Classification of Hazardous Chemicals Under the WHS Regulations for further information; SWA, 2012a). Based on the available information, the following additional (non-GHS) hazard statement is also recommended: AUH014 – Reacts violently with on the available information, the notified chemicals are recommended for hazard classification according to the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004) with the following risk phrases: R22 – Harmful if swallowed R34 – Causes burns Human health risk assessment Provided that control measures are in to minimise exposure, including the use of enclosed/automated processes and PPE, and transport, storage and handling are in accordance with the appropriate codes of practice, the risk to the health of workers from use of the notified chemicals is not considered to be unreasonable. When used in the proposed manner, the notified chemicals are not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the assessed use pattern, the notified chemicals are not considered to pose an unreasonable risk to the environment.
TABLE OF CONTENTS SUMMARY 3 CONCLUSIONS AND REGULATORY OBLIGATIONS 3 ASSESSMENT DETAILS 5 1. APPLICANT AND NOTIFICATION DETAILS 5 2. IDENTITY OF CHEMICAL 6 3. COMPOSITION 6 4. PHYSICAL AND CHEMICAL PROPERTIES 6 5. INTRODUCTION AND USE INFORMATION 7 6. HUMAN HEALTH IMPLICATIONS 8 6.1. Exposure Assessment 8 6.1.1. Occupational Exposure 8 6.1.2. Public Exposure 9 6.2. Human Health Effects Assessment 9 6.3. Health Risk Characterisation 10 6.3.1. Occupational Health and Safety 10 6.3.2. Public Health 11 7. ENVIRONMENTAL IMPLICATIONS 11 7.1. Environmental Exposure & Fate Assessment 11 7.1.1. Environmental Exposure 11 7.1.2. Environmental Fate 12 7.1.3. Predicted Environmental Concentration (PEC) 12 7.2. Environmental Effects Assessment 12 7.2.1. Predicted No-Effect Concentration 13 7.3. Environmental Risk Assessment 13 Appendix A: Physical and Chemical Properties 14 Appendix B: Toxicological Investigations 16 B.1. Acute toxicity – oral 16 B.2. Irritation – skin (in vitro) 16 B.3. Repeat dose toxicity 17 B.4. Genotoxicity – bacteria 18 B.5. Genotoxicity – in vitro 19 B.6. Developmental toxicity 20 Appendix C: Environmental Fate and Ecotoxicological Investigations 21 C.1. Environmental Fate 21 C.1.1. biodegradability 21 C.2. Ecotoxicological Investigations 21 C.2.1. Acute toxicity to fish 21 C.2.2. Acute toxicity to aquatic invertebrates 22 C.2.3. Algal growth inhibition test 22 C.2.4. Inhibition of microbial activity 23 BIBLIOGRAPHY 24
None IDENTITY OF CHEMICAL Tri-C14-15 alkyl citrate CAS 222721-94-0 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tri-C14-15-alkyl esters Tri-C14-15 Alkyl Citrate (INCI name) C48H92O7 to C51H98O7 R = C14-C15 alkyl group 781-823 Da IR spectrum was provided. COMPOSITION 90-95 % None known. (> 1% Chemical Name C14-15 Alcohols CAS No. Weight % 5% None IDENTITY OF ANALOGUE CAS Unknown 2-Hydroxypropane-1,2,3-tricarboxylic acid, tri (hexyl, octyl, decyl) ester
A copy of the (M)SDS should be easily accessible to employees. If products and mixtures containing the notified chemical are classified as hazardous to health in accordance with the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS) as adopted for industrial chemicals in Australia, workplace practices and control procedures consistent with provisions of State and Territory hazardous substances legislation should be in operation. Public Health The following measures should be taken by the notifier to minimise public exposure to the notified chemical: Adequately label the products containing the notified chemical to avoid contact with skin and eyes, and keep out of the reach of children Products containing the notified chemical should only be formulated in non-nitrosating systems, to avoid the formation of hazardous nitrosamines. Disposal The notified chemical should be disposed of to landfill. Emergency procedures Spills or accidental release of the notified chemical should be handled by physical containment, collection and subsequent safe disposal. Regulatory Obligations Secondary Notification This risk assessment is based on the information available at the time of notification. The Director may call for the reassessment of the chemical under secondary notification provisions based on changes in certain circumstances. Under Section 64 of the Industrial Chemicals (Notification and Assessment) Act (1989) the notifier, as well as any other importer or manufacturer of the notified chemical, have post-assessment regulatory obligations to notify NICNAS when any of these circumstances change. These obligations apply even when the notified chemical is listed on the Australian Inventory of Chemical Substances (AICS). Therefore, the Director of NICNAS must be notified in writing within 28 days by the notifier, other importer or manufacturer: (1) Under Section 64(1) of the Act; if additional information on the eye or skin irritation potential of the notified chemical becomes available; additional information on the potential for systemic toxicity of the notified chemical becomes available; Or (2) Under Section 64(2) of the Act; if the function or use of the chemical has changed from a component of liquid laundry detergent, or is likely to change significantly; the amount of chemical being introduced has increased or is likely to increase, significantly; the chemical has begun to be manufactured in Australia; additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health, or the environment. The Director will then decide whether a reassessment (i.e. a secondary notification and assessment) is required.
4.4 FOAM SYSTEMS 4.4.1 Types of Foam Foams are classified by producing action of generation and expansion. Foam concentrate to be used shall conform to IS:4989 2006/UL-162 or Equivalent Standard (Annexure – IV) 4.4.2 Types of Low Expansion Foam For combating large hydrocarbon fires particularly in a contained area like storage tank, foam has proved useful for its inherent blanketing ability, heat resistance and security against burn-back. Aqueous Film Forming Foam (AFFF) compound is technically superior and compatible with other fire fighting agents. Efficient and effective foam delivery system is a vital tool for its usefulness in controlling the fire. The process of adding or injecting the foam concentrate to is called proportioning. The mixture of water and foam compound (foam solution) is then mixed with air in a foam maker for onward transmission to burning surface. 4.4.3 CONVEYING SYSTEMS The system consists of an adequate water supply, supply of foam concentrate, suitable proportioning equipment, a proper piping system, foam makers and discharge devices designed to adequately distribute the foam over the hazard. Conventional systems are of the open outlet type in which foam discharges from all foam outlets at the same time, covering the entire hazard within the confines of the system. There are three types of systems :- i) Fixed ii) Semi-Fixed iii) (i) Foam System Fixed foam conveying system comprises of fixed piping for water supply at adequate pressure, foam concentrate tank, eductor, suitable proportioning equipment for drawing foam concentrate and making foam solution, fixed piping system for onward conveying to foam makers for making foam, vapor seal box and foam pourer. (ii) Semi-Fixed Foam System Semi-fixed foam system gets supply of foam solution through the mobile foam tender. A fixed piping system connected to foam makers cum vapor seal box in case of cone roof tanks and foam maker and foam pourers in the case of floating roof tanks conveys foam to the surface of tank. (iii) Mobile System Mobile system includes foam producing unit mounted on wheels which may be self propelled or towed by a vehicle. These units supply foam through monitors/foam towers to the burning surface. (iv) Sub-surface foam injection This system is for protection of fixed roof storage tanks. It comprises of high back pressure foam generator connected through product lines or separate lines near the bottom of the tank. (v) Under the Seal Foam application
Test 1 ≥ 1000 ≥ 250 none observed negative Test 2 ≥ 500 ≥ 250 none observed negative Present Test 1 ≥ 1000 ≥ 500 none observed negative Test 2 ≥ 500 ≥ 250 none observed negative Remarks - Results In the preliminary test haemolysis was observed for different test conditions at ≥ 500 μg/mL and ≥ 1000 μg/mL, and marked toxicity was noted in all groups. Haemolysis was observed during Test 1 at the end of the exposure period at concentrations ≥ 250 μg/mL in the 4(20)-hour exposure in the absence of metabolic activation and at concentrations ≥ 500 μg/mL in the presence of metabolic activation. Haemolysis was observed during Test 2 at the end of the exposure period at concentrations ≥ 250 μg/mL in both exposure groups in the absence and presence of metabolic activation. The test item did not induce any statistically significant increases in the frequency of cells with aberrations, either in the presence or absence of metabolic activation. Statistically significant increases in aberrations were seen in the positive control groups. Conclusion The notified polymer was not clastogenic to human lymphocytes treated in vitro under the conditions of the test. Test Facility Harlan (2012f)
Flash Point > 110 °C (M)SDS Autoignition Temperature 235 °C Analogue (M)SDS Explosive Properties Not determined Contains no functional groups that would imply explosive properties Oxidising Properties Not determined Contains no functional groups that would imply oxidising properties For full details of tests on physical and chemical properties, refer to Appendix A. Reactivity The notified chemical is expected to be stable under the recommended conditions of storage, in the presence of an inhibitor. It is intended to react as part of the ink curing process. The (M)SDS of the notified chemical recommends against contact with heat, sparks or flames, acids, bases, and oxidising and reducing agents. Physical hazard classification Based on the submitted physico-chemical data depicted in the above table, the notified chemical is not recommended for hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia. INTRODUCTION AND USE INFORMATION (100%) 5 The notified chemical will be imported in inks at up to 30% concentration. (100%) 5 Year 1 2 3 4 5 Tonnes 5-20 5-20 5-20 5-20 5-20 Melbourne and Sydney Arkema Pty Ltd Canon Australia Pty Ltd Fujifilm Australia Pty Ltd The notified chemical as a component of finished ink products (≤ 30%) will be transported in 1L sealed foil pouches. The notified chemical will be used as an ingredient in UV-cured ink and overprint varnish for large-format commercial printers using various substrates including plastic (e.g. Perspex), vinyl, cloth and paper. The chemical will not be manufactured, reformulated or repackaged in Australia. The inks containing up to 30% of the notified chemical will be used in commercial printers. The printing process will be automated. Ink pouches will be manually connected to the printing machine via ink ports and the ink is automatically pumped to the printing head. Print operators monitor the operation and attend to any substrate jams. After printing, the notified chemical will be fixed (UV-cured) with other ink ingredients onto the substrate matrix. Any residual ink within the printing equipment will be wiped clean using rags and solvents. Used rags and dirty solvents will be disposed of by the printing company through licensed waste disposal contractors. HUMAN HEALTH IMPLICATIONS 6.1. Exposure Assessment
Test 2 ≥ 19.53 ≥ 64 ≥ 32 Negative Present Test 1 ≥ 39.06 ≥ 32 ≥ 32 Negative Test 2 - ≥ 32 ≥ 32 Negative Remarks - Results The test substance did not induce statistically significant increase in the frequency of cells with chromosome aberration in either the absence or the presence of metabolic activation. The notified polymer was not clastogenic to human lymphocytes treated in vitro under the conditions of the test. Harlan (2012m)
changed the method of enzyme induction. This deviation from the study protocol did not adversely affect the evaluation of the study outcome. The four S. Typhimurium strains were treated with the test substance by the Ames test plate incorporation (Test 1) as well as the preincubation method (Test 2). Metabolic Activation Test Substance Concentration (µg/plate) Resulting in: Cytotoxicity in Preliminary Test Cytotoxicity in Main Test Precipitation Genotoxic Effect Absent Test 1 > 5000 (TA98, TA100) ≥ 1000 (TA1535) ≥ 500 (TA1537) None Negative Test 2 > 5000 (TA98, TA100) > 100 (TA1535) > 500 (TA1537) None Negative Present Test 1 > 5000 (TA98, TA100) ≥ 5000 (TA1535) ≥ 1600 (TA1537) None Negative Test 2 > 5000 (TA98, > 1000 (TA1535) > 500 (TA1537) None Negative Remarks - Results All four bacterial strains were mutagenic to the positive control in DMSO). Solvent controls (water) were also tested with each strain and the mean numbers of spontaneous revertants were in an acceptable range. Analogue A was not mutagenic to bacteria the conditions of the test. Hüls (1996)
The notified chemical is of low toxicity via the dermal route. Harlan (2013f) Irritation – skin Notified chemical OECD TG 404 Acute Dermal Irritation/Corrosion. Species/Strain Rabbit/New Zealand White (Hsdlf:NZW) Number of Animals 3 Vehicle Test substance administered as supplied. Observation Period 72 hours Type of Dressing Occlusive/Semi-occlusive. Remarks - Method No significant deviations from the OECD protocol. Lesion Mean Animal No. Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Erythema/Eschar 0 0.33 0.33 1 < 48 h 0 Oedema 0 0 0 0 – 0 * Calculated on the of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results Two of the treated sites showed very slight erythema at 1 h and 24 h observations after patch removal. The notified chemical is slightly irritating to the skin. Harlan (2013g) Irritation – eye Notified chemical OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New Zealand White (Hsdlf:NZW) Number of Animals 3 Observation Period 72 hours Remarks - Method No significant deviations from the OECD protocol. Lesion Mean Animal No. Maximum Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Conjunctiva: redness 0.33 0.33 0.33 2 < 48h 0 Conjunctiva: chemosis 0.33 0.33 0.33 2 < 48h 0 Conjunctiva: discharge 0.00 0.33 0.33 2 < 48h 0 Corneal opacity 0.00 0.00 0.00 0 – 0 Iridial inflammation 0.00 0.00 0.00 0 – 0 * Calculated on the of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results No corneal or iridial effects were noted during the study. All treated eyes appeared normal at the 48h observation. The notified chemical is slightly irritating to the eye.
Notified chemical OECD TG 429 Skin Sensitisation: Local Lymph Node Assay Species/Strain Mouse/ CBA/CaOlaHsd Vehicle Acetone:olive oil (AOO) 4:1 v/v Remarks - Method No significant protocol deviations. GLP Compliance. A pre-test was conducted to determine the appropriate vehicle and the highest non-irritant test concentrations for the main study. The maximum technically achievable concentration (75%) was used. A concurrent positive control test was conducted using in AOO 4:1 v/v. Concentration (% w/w) Proliferative response (DPM/lymph node) Stimulation Index (Test/Control Ratio) Test Substance 0 (vehicle control) 93 ± 41 - 25 241 ± 69 2.6 50 669 ± 270 7.2 75 613 ± 189 6.6 Positive Control 25 831 ± 128 8.9 Remarks - Results No clinical signs of irritation on the ears or systemic toxicity were observed in any of the animals during the study period. There was no ear thickness increase ≥ 25%. An EC3 value of 27.2% was determined. The control groups produced satisfactory responses, thus confirming the validity of the test system. There was evidence of induction of a lymphocyte proliferative response indicative of skin sensitisation to the notified chemical. Harlan (2014f) Genotoxicity – bacteria Notified chemical OECD TG 471 Bacterial Reverse Mutation Test. Plate incorporation procedure Species/Strain S. typhimurium: TA1535, TA1537, TA98, TA100 E. coli: WP2uvrA Metabolic Activation System S9 fraction from phenobarbitone/β-naphthoflavone-induced rat liver Concentration Range in Main Test a) With metabolic activation: 1.5 – 5,000 µg/plate b) Without metabolic activation: 1.5 – 5,000 µg/plate Vehicle Dimethyl sulphoxide (DMSO) Remarks - Method No significant protocol deviations. GLP Compliance. No preliminary toxicity study was conducted. Positive control tests were conducted in parallel to the main test using
Treated-rinsed Lesion Mean Score* Maximum Value Maximum Duration of Any Effect Maximum at End of Observation Period Conjunctiva: redness 0 1 < 24 hours 0 Conjunctiva: chemosis 0 0 - 0 Conjunctiva: discharge 0 1 < 24 0 Corneal opacity 0 0 - 0 Iridial inflammation 0 0 - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for ALL animals. Remarks - Results Both the treated-unrinsed and the treated-rinsed eyes showed slight conjunctival irritation 1 hour exposure. All eyes were clear by 24 hours after treatment. The test substance is slightly irritating to the eye. Chevron (1982a) Skin sensitisation Analogue 2 OECD TG 406 Skin Sensitisation - Magnusson and Kligman Species/Strain Guinea pig/ albino Hartley preliminary study Maximum Non-irritating Concentration: intradermal: 1% in peanut oil topical: 5% in peanut oil main study Number of Animals Test Group: 20 Control Group: 19 (20 at onset of study, mortality accounted for decrease) induction Induction Concentration: intradermal: 1% in peanut oil topical: 5% in peanut oil mixed with 0.5 g petrolatum of Irritation challenge phase topical: 0.2% in peanut oil mixed with 0.5 g petrolatum Remarks - Method The concentrations of the test substance used in the main were determined in a preliminary study. The negative control for challenge was 0.2 g peanut oil. The positive control was ethylenediamine. The test animals received two induction treatments, an intradermal injection on day 0 and a topical application on day 7. Animal Challenge Concentration Number of Animals Showing Skin Reactions after: challenge 24 h 48 h Test Group 1% 0/20 0/20 Negative Control 1% 0/15* 0/15* Positive Control 10% 16/18 17/17# * Four animals excluded from counting as irritation was observed on both the treated and control flanks. # one animal excluded from counting as irritation was observed on both the treated and control flanks. - One animal in the negative control and two animals in the positive control died within 48 hours of the topical induction. There were no remarkable body weight changes in surviving animals during the study. There was no evidence of reactions indicative of skin sensitisation to the test substance under the conditions of the test.
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS INTRODUCTION VOLUME USE STD/1541 Mimaki Australia Pty Ltd Ethane, Yes ≤ 30 tonnes per annum Component of inkjet printing inks CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available information, the notified chemical is recommended for hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia. The recommended hazard classification is presented in the table below. Hazard classification Hazard statement Flammable Liquids Category 4 H227 – Combustible liquid. Reproductive Toxicity Category 2 Suspected Human Reproductive Toxicant H361 – Suspected of damaging fertility or the unborn child. Based on the available information, the notified chemical is recommended for hazard classification according to the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004) with the following risk phrase: R62/63: Possible risk of impaired fertility/Possible risk of harm to the unborn child Human health risk assessment Provided that the recommended controls are being adhered to, under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the PEC/PNEC ratio and the assessed use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Hazard Classification and Labelling The notified chemical should be classified as follows: Flammable Liquids Category 4: H227 – Combustible liquid. Reproductive Toxicity Category 2 Suspected Human Reproductive Toxicant: H361 – Suspected of damaging fertility or the unborn child. The above should be used for products/mixtures containing the notified chemical, if applicable, based on the concentration of the notified chemical present and the intended use/exposure scenario. The notifier should comply with relevant State and Territory OHS labelling requirements. NICNAS will refer the notified chemical to Safe Work Australia, for their consideration.
Positive controls: i) without S9: N-ethyl-N’-nitro-N-nitrosoguanidine (WP2uvrA, TA100, TA1535), 9-Aminoacridine (TA1537), (TA98); ii) with S9: 1-Aminoanthracene (TA100, TA1535, TA1537, WP2uvrA), Benzo(a)pyrene (TA98). The dose for Test 2 was determined by the results of Test 1. Metabolic Activation Test Substance Concentration (µg/plate) Resulting in: Cytotoxicity in Preliminary Test* Cytotoxicity in Main Test Precipitation Genotoxic Effect Absent Test 1 - ≥ 150 > 5000 Negative Test 2 ≥ 150 > 500 Negative Present Test 1 - ≥ 500 > 5000 Negative Test 2 ≥ 500 > 1500 Negative * Not conducted Remarks - Results Positive and negative controls performed as expected confirming the validity of the test system. No significant increases in the frequency of the revertant colonies were recorded following treatment with the notified chemical at any dose level, with or without metabolic activation. The notified chemical was not mutagenic to bacteria the conditions of the test. Harlan (2014j) Genotoxicity – in vivo Notified chemical OECD TG 474 Mammalian Erythrocyte Micronucleus Test. EC Directive 2000/32/EC B.12 Mutagenicity - Mammalian Erythrocyte Micronucleus Test. Species/Strain Hsd: ICR (CD-1®) Route of Administration Oral – gavage Vehicle Arachis oil Remarks - Method Range finding test found no marked difference in toxic response between the sexes. It was therefore considered acceptable to use males only for the main test. Group Number and Sex of Animals Dose mg/kg bw Sacrifice Time I (vehicle control) 7 M 0 24 II (low dose) 7 M 250 24 III (mid dose) 7 M 500 24 IV (high dose) 7 M 1000 24 V (high dose) 7 M 1000 48 VI (positive control, CP) 5 M 50 24 CP=cyclophosphamide.
groups showed eosinophilic inclusions in the olfactory epithelium in the nasal turbinates with an increased incidence and/or severity in treated and higher dose animals. Remarks – Results The clinical signs in this study were consistent with exposure to an irritant atmosphere. However, the test substance may cause serious damage to respiratory tract by prolonged exposure through inhalation. The Low Observed (Adverse) Effect (LO(A)EL) was established as 0.0038 mg/L/6 h/day in this study, based on evidence of respiratory tract irritation at all doses. Huntingdon Life Sciences Ltd (2001) Genotoxicity – bacteria Notified chemical (92.8%) OECD TG 471 Bacterial Reverse Mutation Test (1997). EC Directive 92/69/EC B.13/14 Mutagenicity – Reverse Mutation Test using Bacteria (1992). incorporation (Test 1)/Pre incubation (Test 2) Species/Strain S. typhimurium: TA1535, TA1537, TA98, TA100, TA102 Metabolic Activation System S9 microsomal fraction from β-naphthoflavone/phenobarbital-induced rat Concentration Range in Main Test a) With metabolic activation: 33-5000 b) Without metabolic activation: 33-5000 µg/plate Vehicle DMSO Remarks - Method No deviation from standard protocol Metabolic Activation Test Substance Concentration (µg/plate) Resulting in: Cytotoxicity in Preliminary Test Cytotoxicity in Main Test Precipitation Genotoxic Effect Absent Test 1 > 5000 > 5000 > 5000 Negative Test 2 > 5000 > 5000 Negative Present Test 1 > 5000 > 5000 > 5000 Negative Test 2 > 5000 > 5000 Negative Remarks - Results No significant increase in revertant colony numbers of any of the five tester strains was observed at any dose level in the presence or absence of metabolic activation. Negative controls were within the historical limits and positive controls demonstrated the sensitivity of the The test substance was not mutagenic to bacteria under the conditions of the test. RCC (1998a) Genotoxicity – in vitro Mammalian Chromosome Aberration Test Troysol LAC (containing the notified chemical at ~50% concentration) OECD TG 473 In vitro Mammalian Cytogenetic Test (1998). EC Directive 92/69/EC B.10 Mutagenicity - In vitro Mammalian Chromosome Aberration Test (1992).
SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS INTRODUCTION VOLUME USE STD/1567 Clariant (Australia) Pty Ltd D-Glucitol, N-(C16-18 and C18-unsatd. acyl) derivs. ND* < 5 tonnes per annum Component of cosmetic and household cleaning products * ND = not determined CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available information, the notified chemical is not recommended for classification according to the Globally Harmonised System of Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia, or the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004). The environmental hazard classification according to the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) is presented below. Environmental classification under the GHS is not mandated in Australia and carries no legal status but is presented for information purposes. Hazard classification Hazard statement Acute Category 1 H400 – Very toxic to aquatic life Chronic Category 3 H412 – Harmful to aquatic life with long lasting effects health risk assessment Provided that the recommended controls are adhered to, under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the PEC/PNEC ratio and the reported use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Occupational Health and Safety A person conducting a business or undertaking at a workplace should implement the following engineering controls to minimise occupational exposure to the notified chemical during reformulation processes: Enclosed, automated processes, where possible Adequate general ventilation and local exhaust ventilation A person conducting a business or undertaking at a workplace should implement the following safe work practices to minimise occupational exposure to the notified chemical during reformulation processes: Avoid contact with eyes Avoid formation of mists/aerosols off
of silica was found within the untreated control and was considered to be the background level. Dermal absorption of silica contents of the test substance was considered by the study authors to be negligible under the conditions of the test. Dermal Technology Laboratory (2013) Skin sensitisation – mouse local lymph node assay (LLNA) Bindzil CC 301 (Notified chemical at < 50% concentration) OECD TG 429 Skin Sensitisation: Local Lymph Node Assay EC Directive 2004/73/EC B.42 Skin Sensitisation (Local Lymph Node Assay) Species/Strain Mouse/CBA/J Vehicle N,N-Dimethyl formamide (DMF) Preliminary study Yes Positive control Positive control was not conducted in parallel with the test substance but had been conducted previously in the test laboratory using Remarks - Method No significant deviations of protocol were noted. Concentration (% w/w) Number and sex of animals Proliferative response (DPM/lymph node) Stimulation Index (SI) (Test/Control Ratio) Test Substance 0 (vehicle control) 5 F 623 1.0 25 5 F 532 0.9 50 5 F 476 0.8 100 5 F 423 0.7 Historical Positive Control* 0 (vehicle control) 5 F 543 1.0 5 5 F 583 1.1 10 5 F 1696 3.1 25 5 F 1994 3.7 * α-Hexylcinnamaldehyde Remarks - Results The test substance did not elicit a SI ≥ 3 when tested up to 100% concentration (with notified chemical at < 50% concentration). There was no evidence of induction of a lymphocyte proliferative response indicative of skin sensitisation to the notified chemical under the conditions of the test. WIL Research Genotoxicity – bacteria Bindzil CC 301 (Notified chemical at < 50% concentration) OECD TG 471 Bacterial Reverse Mutation Test EC Directive 2000/32/EC B.13/14 Mutagenicity – Reverse Mutation Test using Bacteria incorporation procedure Species/Strain S. typhimurium: TA1535, TA1537, TA98 and TA100 E. coli: WP2uvrA Metabolic Activation System Rat liver S9 fraction mix induced by Aroclor 1254