85.8 % (on standing the notified chemical will disproportionate and reach an equilibrium value of approximately 72%) HAZARDOUS IMPURITIES Chemical Name Methyltriacetoxysilane CAS No. 4253-34-03 Weight % 2.0-2.1%* Hazardous Properties Hazardous (as a group, the alkoxysilanes tend to be irritant/corrosive (Micromedex; Meditext 2002)) Chemical Name Acetic anhydride CAS No. 108-24-7 Weight % 0.8-0.93%* Hazardous Properties Hazardous: causes (on the List for Designated Hazardous Substances (NOHSC, 1999a)) Chemical Name Methylacetoxydiisopropoxysilane CAS No. No CAS number Weight % 16.67-15.90* Hazardous Properties Hazardous (as a group, the alkoxysilanes tend to be irritant/corrosive (Micromedex; Meditext 2002))
Chemical Name Acetic acid CAS No. 64-19-7 Weight % 0.23-0.26%* Hazardous Properties Hazardous: R35: causes severe R10 Flammable (on the List for Designated Hazardous Substances 1999a)) * Impurities determined by GC/MS ADDITIVES/ADJUVANTS None INTRODUCTION AND USE INFORMATION MODE OF INTRODUCTION OF NOTIFIED CHEMICAL (100%) OVER NEXT 5 The notified chemical will not be manufactured in Australia. It will be imported as a minor ingredient in silicone caulking compounds (GE Silicone rubber compound CRTV1488), containing up to 0.6% of the notified chemical. MAXIMUM INTRODUCTION VOLUME OF NOTIFIED CHEMICAL (100%) OVER NEXT 5 YEARS Year 1 2 3 4 5 Tonnes 2-4 4-8 4-8 4-8 4-8 USE The notified chemical will be used as a curing/cross linking agent (catalyst) in acetoxy silicone sealants (CRTV1488) at concentrations of 0.45% to 0.6 %. It becomes part of the polymer matrix during curing, rapidly becoming a curing rubber. The product (sealant) will be used for sealing and weather proofing buildings, glazing, roofing, rainwater and cladding joints. PROCESS AND RELEASE INFORMATION Distribution, Transport and Storage PORT OF ENTRY Not provided IDENTITY OF MANUFACTURER/RECIPIENTS The notified chemical will be transported directly from wharf or GE warehouse to the packing plants. TRANSPORTATION AND PACKAGING The notified chemical will be imported already packaged in airtight dispensing tubes (cartridges), or in lined 200 kg drums for packing into cartridges Operation Description Packaging The packaging process is a closed and automatic system so that no air (and thus moisture) comes into contact with the paste. The caulking paste will be transferred from the lined 200 kg drums via pneumatic ram and lift pump to the automatic filling machines. In the filling machine, the cartridge tube is automatically filled and then sealed to prevent the entry of air and moisture. The cartridges are packed into cartons and stored until customers require them. End use
RESULTS Group Number and Sex of Animals Dose mg/kg bw Mortality 5 2000 None 5 females 2000 None LD50 2000 mg/kg bw of Toxicity - Local Necrosis was observed in 7 out of 10 animals. Erythema and oedema were observed in all the test sites and persisted for the first 7 days Signs of Toxicity - Systemic None Effects in Organs None Remarks - Results The notified chemical was corrosive as necrosis was observed in 7 out of 10 application sites CONCLUSION The notified chemical is of low toxicity via the dermal route. TEST FACILITY Toxickon Corporation (2001b) toxicity – inhalation Remarks Not provided Irritation – skin TEST SUBSTANCE Notified chemical METHOD OECD TG 404 Acute Dermal Irritation/Corrosion. EC Directive 92/69/EEC B.4 Acute Toxicity (Skin Irritation) USEPA 40/798. Species/Strain Rabbit/New Zealand White Number of Animals 3 (2 males and 1 female) Vehicle None Observation Period Not known Type of Dressing Semi-occlusive. Remarks - Method Four topical application to intact skin RESULTS Lesion Mean Animal No. 1 2 3 Maximum Value Maximum Duration of Any Effect Maximum at End of Observation Period Erythema/Eschar 0.67 0.67 0.67 1 48 hours 0 Oedema 0 0 0 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results Very slight to well defined erythema was observed in all rabbits (3) after 1 hour of application. All rabbits exhibited very slight erythema at both 24 and 48 hour observation periods. The irritation was reversed with no signs of erythema present at the 72 hour observation. CONCLUSION The notified chemical is slightly irritating to skin. TEST FACILITY Toxikon Corporation (2001c) Irritation – eye