SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS INTRODUCTION VOLUME USE STD/1595 Cintox Australia Pty Ltd L-Lysine, sodium salt (1:?) (INCI name: Sodium dilauramidoglutamide lysine) ND* < 2 tonnes per annum Cosmetic ingredient *ND = not determined CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification Based on the available information, the notified chemical is not recommended for classification according to the Globally Harmonised System of Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia, or the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004). The environmental hazard classification according to the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) is presented below. Environmental classification under the GHS is not mandated in Australia and carries no legal status but is presented for information purposes. Hazard classification Hazard statement Acute Category 2 H401 – to aquatic life Human health risk assessment the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. Based on the available information, when used at ≤ 1% concentration in cosmetic products, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment On the basis of the PEC/PNEC ratio and the reported use pattern, the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Occupational Health and Safety A person conducting a business or undertaking at a workplace should implement the following engineering controls to minimise occupational exposure to the notified chemical during reformulation: Enclosed, automated processes, where possible A person conducting a business or undertaking at a workplace should implement the following safe work practices to minimise occupational exposure during handling of the notified chemical during reformulation: Avoid contact with skin and eyes
Reference NMR, IR, LC-MS and UV-Vis spectra were provided. COMPOSITION ≥ 90% None (> 1% Chemical Name N-(1-oxododecyl)-glutamic acid (neutralised partially by sodium hydroxide) CAS No. Unassigned Weight % ≤ 8 Chemical Name Dodecanoic acid (neutralised partially by sodium hydroxide) CAS No. Unassigned Weight % ≤ 2 Chemical Name 1,3-Butanediol (for products LB-10 and LB-30G) CAS No. 107-88-0 Weight % 10% (LB-10); 6% (LB-30G) PHYSICAL AND PROPERTIES Appearance at 20 ºC and 101.3 kPa: white powder Property Value Data Source/Justification Melting Point Decomposes without melting at 244 °C Measured Boiling Point Decomposes without boiling at 244 °C Measured Density 1,205 kg/m3 at 20 °C Measured Vapour Pressure 2.8 × 10-1 kPa at 20 °C Measured Water Solubility > 200 g/L at 20 °C Measured Hydrolysis as a Function of pH t½ > 1 year at pH 4, 7 and 9 Measured Partition Coefficient Log POW > 6.5 Measured; expected to partition to phase boundaries based on surface activity Surface Tension 35.2 mN/m at 20 °C Measured Adsorption/Desorption Log KOC < 1.25 Measured; expected to adsorb to soil and sediment based on surface activity Dissociation Constant pKa = 5.2 at 20 °C (acid) pKa = 8.0 at 20 °C (base) Measured Particle Size Inhalable fraction (< 100 m): 16% Respirable fraction (< 10 m): 0.03% Measured Flammability Not highly flammable Measured Pyrophoric properties No pyrophoric properties Measured Autoignition Temperature 389 °C Measured Explosive Properties No explosive properties Measured Oxidising Properties No oxidising properties Measured For full details of tests on physical and chemical properties, refer to Appendix A. Reactivity The notified chemical is expected to be stable under normal conditions of use.