SUMMARY The following details will be published in the NICNAS Chemical Gazette: ASSESSMENT REFERENCE APPLICANT(S) CHEMICAL OR TRADE NAME HAZARDOUS INTRODUCTION VOLUME USE STD/1490 Pacific Environment Operations Pty Ltd Chemical in Kuriverter IK-110 ND* < 500 tonnes per annum control agent for Reverse Osmosis water treatment systems *ND = not determined CONCLUSIONS AND REGULATORY OBLIGATIONS Hazard classification on the available information, the notified chemical cannot be classified according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia, or the Approved Criteria for Classifying Hazardous Substances (NOHSC, 2004). Human health risk assessment Under the conditions of the occupational settings described, the notified chemical is not considered to pose an unreasonable risk to the health of workers. When used in the proposed manner, the notified chemical is not considered to pose an unreasonable risk to public health. Environmental risk assessment on the PEC/PNEC ratio and the assessed use pattern, the treated discharge containing the notified chemical is not considered to pose an unreasonable risk to the environment. Recommendations Occupational Health and Safety A person conducting a business or undertaking at a workplace should implement the following safe work practices to minimise occupational exposure during handling of the product containing the notified chemical as introduced: Avoid skin and eye contact A person conducting a business or undertaking at a workplace should ensure that the following personal protective equipment is used by workers to minimise occupational exposure to the product containing the notified chemical as introduced: Coveralls Safety goggles Gloves Guidance in selection of personal protective equipment can be obtained from Australian, Australian/New Zealand or other approved standards. A copy of the (M)SDS should be easily accessible to employees. If products and mixtures containing the notified chemical are classified as hazardous to health in accordance with the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS) as adopted for industrial chemicals in Australia, workplace practices and control procedures consistent with provisions of and Territory hazardous substances legislation should be in operation.
Metabolic Activation Test Substance Concentration (μg/mL) Exposure Period Harvest Time Absent Test 1 0*, 412, 588, 840*, 1201*, 1715*, 2450* 3 h 24 h Test 2 0*, 36.8, 73.5, 147, 294*, 588*, 840*, 1201, 1715 24 h 24 h Present Test 1 0, 412, 588, 840, 1201*, 1715*, 2450*, 3500 3 h 24 h *Cultures selected for metaphase analysis. Metabolic Activation Test Substance Concentration (µg/mL) Resulting in: in Test Cytotoxicity in Main Test Precipitation Genotoxic Effect Absent Test 1 ≥ 1611 ≥ 1715 > 2450 negative Test 2 ≥ 641 ≥ 840 > 1715 negative Present Test 1 ≥ 2016 ≥ 1715 > 3500 negative Remarks - Results The positive and vehicle controls gave satisfactory responses, confirming the validity of the test system. The test substance did not induce any statistically significant increases in the frequency of cells with aberrations. The test substance was not clastogenic to lymphocytes treated in vitro under the conditions of the test. Biosafety (2011)