Dissociation constant Expected to dissociate completely. Flash point 87 °C (ABIL Quat 3270); 93 °C (ABIL Quat 3272); >100 °C (ABIL Quat 3474, ABIL Quat 3676) Flammability Not measured. Autoignition temperature Not measured. Explosive properties Not measured. Oxidising products At high temperatures the trade products oxidise giving rise to propionaldehyde, lactic acid, pyruvic acid and acetic acid. Reactivity/Stability There is no specific reactivity.
A.1.3 Acute toxicity – oral Test Substance ABIL Quat 3474 Method Similar to OECD TG 401 Acute Oral Toxicity – Limited Test Species/Strain Rat/Sprague Dawley (albino) Vehicle None Remarks – Method No significant protocol deviations Results Group Number and sex of animals Dose (mg/kg bw) Mortality 1 5 males, 5 females 5000 0 LD50 >5000 mg/kg bw Remarks – Signs of toxicity None Conclusion ABIL Quat 3272 is of low toxicity via the oral route Test Facility Product Safety Labs (1995a) A.1.4 Irritation – skin Test Substance ABIL Quat 3270 Method Primary Dermal Irritation Test US Federal Guidelines 16 CFR 1500.41 PSL Protocol 002/P201 Species/Strain Rabbit/New Zealand White (albino) Number of animals 6 males Vehicle Distilled water Observation period 3 days Type of dressing Semi-occlusive Remarks – Method Abraded skin and intact skin sites on each animal were tested with the test substance as a 10% w/w solution for a 24 hour exposure period. Observations were recorded at 24 and 72 hours after patch removal only. The FHSA Primary Skin Irritation Scoring system was used to grade the skin reaction observations. Original data tables were not provided. Results Remarks – Results At 24 hour post-dosing, moderate to well-defined erythema was observed at all abraded and intact sites. Oedema ranging from very slight to slight was observed at all but one abraded site and at all intact sites. By 72 hours, erythema in four rabbits increased from well-defined to severe. Thickening of the skin was noted at all sites. The remaining two rabbits had eschar at the abraded site, with erythema being stable at the intact sites. Oedema cleared in one rabbit and remained stable
Observation period 72 hours Remarks – Method 0.1 mL of test substance was instilled as a 10% w/w solution into the right eyes of the test animals. Observations were taken at 24, 48 and 72 hours post-dosing. The Draize scoring system was used to grade the eye reaction observations. Results Lesion Mean score* Animal No. Maximum value Maximum duration of any effect Maximum value at end of observation period 1 2 3 4 5 6 Conjunctiva: redness 2 2 1 2 1.7 1.3 2 >72 hours 2 Conjunctiva: chemosis 1.7 0.7 1.7 1 1 1 2 >72 hours 1 Corneal opacity 0 0 0 0 0 0 0 N/A 0 Iridial inflammation 0 0 0 0 0 0 0 N/A 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for each animal. Remarks - Results No corneal opacity or iritis were observed during the test period. At 24 hours after dosing, all treated eyes exhibited slight to mild hyperaemia, chemosis and ocular discharge. A slight increase in the severity of the irritation from 24 to 48 hours was observed, and although there was a slight decrease in irritation thereafter, irritation persisted in all rabbits through 72 hours. Conclusion ABIL Quat 3474 is slightly irritating to the eye under the conditions of the test. Test Facility Product Safety Labs (1995c) A.1.9 Skin Sensitisation – GPMT Test Substance ABIL Quat 3270 Method OECD TG 406 Skin Sensitisation – GPMT Species/Strain Guinea pig/Pirbright White Vehicle Water preliminary study Maximum Non-irritating Concentration: intradermal: 0.5% topical: 1% main study Number of Animals Test Group: 20 Control Group: 10 induction phase Induction Concentration: intradermal: 0.5% topical: 10% Signs of Irritation Not reported challenge phase Challenge Concentration: topical: 1%