Supplementary Table 1: Main Characteristics of Included Studies Authors Drug(s) Drug range or mean dosage (mg) Concomitant anxiolytics Study duration (weeks) Time considered in our as endpoint Number of subjects (ITT) % female Mean Age Comorbidities Patients having INSOMNIA as side effect Patients having SOMNOLENCE as side effect Sponsor (Abbasi et al. 2012)() Sertraline + Placebo 200 No 6 T6 20 30 34.2±6.9 No 1 - No (Abolfazli et al. 2011)() Fluoxetine + Placebo 40 No 6 T6 22 50 33.3±6.1 No 5 - No (Aguglia et al. 1993)() Fluoxetine Sertraline 28 72 Yes 8 T8 48 40 87.5 97.5 58.9±17.3 57.5±15.5 No 2 1 1 4 No (Akhondzadeh et al. 2003)() Fluoxetine 60 No 6 T6 24 62.5 36.2±8.1 No 4 7 No (Akhondzadeh et al. 2009)() Fluoxetine + Placebo 40 No 6 T6 20 60 34.2±4.96 No 4 - No (Akkaya et al. 2006)() Reboxetine Venlafaxine 8 150 No 10 T10 50 43 74 81.4 40.4±10.7 42.0±11.0 No - - 22 1 No (Alvarez et al. 2012)() Venlafaxine Placebo 225 Yes 6 T6 113 105 54.9 65.7 45.0±10.3 42.0±10.9 No 14 5 - - Yes (Amini et al. 2005)() Fluoxetine Mirtazapine 20 30 Yes 6 T6 15 16 60 68.8 37.7±11.3 35.0±10.6 No - - 2 6 No (Andreoli et al. 2002)() Reboxetine Fluoxetine 8-10 20-40 Yes 8 T8 126 127 67 65 40.0±.12.0 40.0±.11.5 No 23 15 - - No trial
(Ansseau et al. 1994)() Paroxetine 20-30 No 6 T6 56 46.4 43.7± 11.5 No - 5 Yes (Appelhof et al. 2004)() Paroxetine + Placebo 30 Yes 8 T8 45 64 46.2±11.2 No 19 21 No (Baldwin et al. 2008)() Milnacipran 100 No 12 T12 80 80 41.8±10.0 No 10 - Yes (Baldwin et al. 2012)() Duloxetine Placebo 60 Yes 8 T8 155 148 67.7 69.6 45.3±12.0 43.4±12.5 No 13 6 - - Yes (Behnke et al. 2003)() Mirtazapine Sertraline 38.3 92.7 Yes 8 T8 176 169 55.7 61.5 42 ± 11 41 ± 12 No 9 15 35 13 Yes (Benkert et al. 2000)() Mirtazapine Paroxetine 32.7 22.9 Yes 6 T6 135 134 63 65 47.2± 11.1 47.3± 10.3 No - - 15 10 Yes (Benkert et al. 2006)() Venlafaxine 225 No 6 T6 115 - - No 17 - Yes (Benkert et al. 1996)() Venlafaxine 225 Yes 6 T6 85 69.4 48.9± 11.7 No 8 - No (Berk et al. 1997)() Duloxetine 20 Yes 6 T6 80 77.5 38 No 17 7 No (Berzewski et al. 1997)() Reboxetine 8-20 Yes 6 T6 130 64.6 45.4± 12.0 No 10 4 No (Bielski et al. 2004)() Escitalopram Venlafaxine 20 225 Yes 8 T8 97 98 69.4 47 37.3± 12.3 37.5± 11.6 No - - 9 17 Yes (Blier et al. 2010)() Fluoxetine + Placebo 20 Yes 6 T6 28 - 43.8 ± 1.8 No 3 3 Yes
Escitalopram Placebo 20 123 119 68 60 39.6±12.0 40.1±10.6 14 3 - - (Byerley et al. 1988)() Fluoxetine Placebo 20-80 Yes 6 T6 32 29 75 61 38.9±10.7 37.5±9.1 No 4 2 - - Yes (Calabrese et al. 2003)() Citalopram 24.6 No 6 T6 55 73 43 No 2 1 Yes (Chouinard et al. 1999)() Paroxetine Fluoxetine 25.5 27.5 Yes 12 T12 102 101 40.6± 10.7 41.2± 10.7 No No (Claghorn et al. 1992)() Paroxetine Placebo 30 No 6 T6 168 179 50 54 40.6 42.8 Personality disorders 25 8 34 14 Yes (Claghorn et al. 1995)() Mirtazapine Placebo 16.5 Yes 6 T6 42 40 52.4 45 39 40 No - - 27 2 Yes (Claghorn et al. 1996)() Fluvoxamine Placebo 92.7 ± 46.9 No 6 T6 50 50 64 64 39.0±10.9 No 3 5 19 4 No (Clayton et al. 2006)() Bupropion Escitalopram Placebo 300-450 10-20 Yes 8 T8 276 281 273 58 57 60 37±12 36±11 36±11 No 39 28 21 8 22 14 Yes (Clerc et al. 1994)() Venlafaxine Fluoxetine 200 40 No 6 T6 33 34 69.7 67.6 49.0 53.6 No 0 1 - - Yes et al. 2001)() Fluvoxamine Milnacipran 200 100 Yes 6 T6 56 57 82.1 75.4 51.2± 12.6 48.7± 15.1 No 1 0 6 1 Yes
(Cohn et al. 1985)() Fluoxetine Placebo 20-80 No 6 T6 54 58 72.2 63.6 41 44 No 11 4 20 9 No (Cohn et al. 1992)() Paroxetine Placebo 30.9 Yes 6 T6 40 40 60 42.5 42.3 41.3 No 8 5 9 7 No (Coleman et al. 1999)() Bupropion Sertraline Placebo 290 106 Yes 8 T8 119 115 121 56 54 59 38.1 38.3 38.5 No 24 20 8 - - - Yes (Coleman et al. 2001)() Bupropion Fluoxetine Placebo 319 26 No 8 T8 150 154 152 63 66 61 36.6 37.1 36.7 No 21 15 10 4 17 6 Yes (Cooper-Kazaz et al. 2007)() Sertraline + Placebo 85.5 ± 15.7 Yes 8 T8 50 58 41.0± 55.8 No 31 34 No (Corrigan et al. 2000)() Fluoxetine Placebo 20 No 8 T8 33 34 - - 42 42 No 6 1 3 2 No (Costa e Silva 1998)() Fluoxetine Venlafaxine 20-40 75-150 Yes 8 T8 185 194 77.8 80.9 39.8± 10.3 40.5± 10.7 No 15 12 3 16 No (Cunha et al. 2007)() Venlafaxine Placebo 75 No 6 T6 14 17 85.7 64.7 77.6 ±7.3 77.6 ±5.8 Mild or moderate dementia 0 2 1 1 No (Cunningham et al. 1994)() Venlafaxine Placebo 156-160 Yes 6 T6 72 76 - - 40.7 40.7 No - - 31 9 Yes (Cunningham et al. 1997)() Venlafaxine XR Venlafaxine IR 115-125 124-140 Yes 12 T12 97 96 63.0 66.6 39.7± 11.0 42.8± 11.4 No - - 20 23 Yes
Placebo 100 58.6 39.9± 10.1 - 9 (Currier et al. 2003)() Bupropion 265± 65 No 6 T6 20 30 41.0 ±7.0 No 4 - Yes (Currier et al. 2004)() Citalopram 31.3± 11.1 No 6 T6 17 29.4 42.9± 8.4 Dysthymia 3 - Yes (Dam et al. 1998)() Fluoxetine + Placebo 20 No 6 T6 17 - - No 2 0 Yes (Serretti et al. 2005)() Fluvoxamine - Yes 6 T6 61 73.4 55.7 Personality disorders 2 - No (De Montigny et al. 1999)() Venlafaxine 260 No 8 T8 158 72.2 42.9± 9.2 Dysthymia 74 - Yes et al. 1988)() Fluoxetine 31.4 No 6 T6 18 61.1 35.4± 8.6 No 3 7 Yes (DeMartinis et al. 2007)() Desvenlafaxine Desvenlafaxine Desvenlafaxine Placebo 100 200 400 No 8 T8 118 116 116 120 65 61 54 68 40.4±12.1 40.7±12.8 39.0±12.6 40.0±12.8 No 26 21 35 10 24 25 30 10 Yes (Demir et al. 2002)() Reboxetine 8-10 No 8 T8 24 83.3 - No 7 - No (Detke et al. 2002)() Duloxetine Placebo 60 Yes 9 T9 128 139 66 71 41±13 41±15 No 21 19 13 9 Yes
EMA Venlafaxine 1998 (Protocol N.. 0600A1-372 US) Fluoxetine Venlafaxine Placebo 20-80 75-375 Yes 6 T6 152 155 152 65.8 63.9 59.9 38.0± 9.9 40.0± 9.5 39.0± 10.6 No 39 51 15 18 27 16 Yes EMA Venlafaxine study 1995 (Protocol N. Venlafaxine Venlafaxine Paroxetine Placebo 74.8 148.2 20 Yes 8 T8 83 78 80 82 69.8 64.1 55 68.2 44.9±12.9 44.3±10.6 48.2±12.5 44.7±11.6 No 2 3 3 2 6 7 11 2 Yes EMA Venlafaxine 1996 (Protocol N. 0600B-209-US) Venlafaxine Placebo 176.6 Yes 8 T8 91 100 63.7 59 40 42 No 33 15 26 11 Yes (Fabre et al. 1996)() Fluvoxamine Placebo 50-117 No 6 T6 46 44 76.1 68.2 - - No 11 2 19 2 Yes (Fabre et al. 1992)() Paroxetine Placebo 28.7 Yes 6 T6 38 36 55.3 63.8 35.6 35.9 No - - 10 6 No (Fava et al. 1998)() Fluoxetine Paroxetine Placebo 20-80 20-50 Yes 12 T12 54 55 19 - - - 41.3± 12.6 41.3± 12.6 41.3± 12.6 No 11 16 2 - - - Yes (Fava et al. 2001)() Mirtazapine 24.3-27.5 No 8 T8 50 60 43.8± 10.0 No 3 25 Yes (Fava et al. 2005)() Fluoxetine Placebo 20 No 12 T12 47 43 53 65 36.7 ± 9.6 37.8± 12.0 No 5 6 6 3 Yes trial trial
FDA Deuloxetine study (Application number 21-427) Duloxetine Placebo 20-40 Yes 8 T8 1139 777 - - - - No 125 47 80 23 Yes FDA Escitalopram study I (Application number 21-323) Escitalopram Placebo 10-20 Yes 8 T8 715 527 - - - - No 64 24 23 12 Yes FDA Escitalopram I table 2 (Application number 21-323) Escitalopram Escitalopram Placebo 10 20 Yes 8 T8 310 125 311 - - - - - - No 22 17 12 12 11 3 Yes FDA Escitalopram study II Citalopram Escitalopram Escitalopram Placebo 20 10 20 Yes 8 T8 125 124 128 127 62.4 70.6 67.2 59.0 40 ± 11.5 40.6±12.3 39.6± 12.1 40.3± 10.6 No 14 12 17 4 - - - - Yes FDA Fluvoxamine study Fluvoxamine Placebo 20-80 Yes 8 T8 1728 975 - - - - No 276 88 225 58 Yes FDA Mirtazapine study (ID: 3210056) Mirtazapine Placebo 21-32 Yes 8 T8 453 361 - - - - No - - 245 65 Yes FDA Paroxetine study I (Reference ID: 3231319) Paroxetine Placebo 20-50 Yes 8 T8 421 421 - - - - No 55 25 97 38 Yes trial
Citalopram Citalopram Placebo 40 60 131 129 129 60 53 55 39 38 38 28 31 14 29 25 5 (Feighner et al. (I) 1989)() Fluoxetine Placebo 80 No 6 T6 61 59 69 79 45.0±2.0 39.7±1.9 No - - 5 2 No (Feighner et al. (II) 1989)() Fluvoxamine Placebo 145 No 6 T6 31 19 77 89 41 41 No 4 3 9 1 No (Ferreri et al. 2001)() Fluoxetine 20 Yes 6 T6 38 71.1 45± 12 No - 0 Yes (Finkel et al. 1999)() Sertraline 102± 44 Yes 12 T12 38 67 74 ± 4.4 No 5 - No (Flores et al. 2004)() Mirtazapine 35.1 No 8 T8 142 - 18-70 No - 18 Yes (Forlenza et al. 2001)() Sertraline 50 Yes 8 T8 27 77.8 68.8 No 16 2 Yes (Fornaro et al. 2011)() Duloxetine 60 Yes 12+12 T12 40 60 47 ± 10.7 No 29 4 No (Fortner et al. 1999)() Bupropion 222± 18 No 8 T8 18 61.1 69.9 No 2 - Yes (Garlow et al. 2012)() Sertraline + Placebo 141.6±52.2 No 12 T12 77 68 41.4 ±11.5 No 21 - No (Gaynor et al. (I) 2011)() Duloxetine Placebo 60 Yes 8 T8 262 266 68.7 69.2 46.2±13 45.7±13 No 24 8 - - Yes (Gaynor et al. (II) 2011)() Duloxetine 60 No 8 T8 261 70.1 45.2 ±12.5 No 14 22 Yes
(Hsu et al. 2011)() Citalopram Sertraline 22.9 ± 8.5 57.1± 17.9 Yes 6 T6 21 21 52.4 66.7 43.4± 11.4 38.0± 13.8 No 1 3 1 3 No (Hudson et al. 2007)() Duloxetine 30-60 Yes 12+26 T12 533 71.9 43.4± 12.7 Dysthymia 56 72 Yes (Isaac et al. 2003)() Milnacipran + Placebo 100 No 6 T6 39 51.3 32.3± 10.0 No 1 - No (Jazayeri et al. 2008)() Fluoxetine + Placebo 20 No 8 T8 16 75 35.1± 9.4 Dysthymia 1 2 No (Jefferson et al. 2006)() Bupropion Placebo 300-450 Yes 8 T8 135 139 66 69 40.0 39.8 No 10 2 - - Yes (Kamijima et al. 2006)() Sertraline 85.0± 24.2 No 8+16 T8 361 60.4 40.4± 10.8 No - 64 Yes (Kanemoto et al. 2004)() Milnacipran 75-150 Yes 8 T8 66 56.1 56.8± 14.1 No - 1 No (Kang et al. 2009)() Mirtazapine Venlafaxine 27.6 ± 8.6 141.4±62.4 No 8 T8 73 53 76.7 77.4 46.5± 12.6 47.2± 12.0 No 1 0 7 3 Yes (Kaplan et al. 2002)() Venlafaxine 142 No 6 or 8 T6 or T8 69 74.0 38.6 No 6 - Yes (Kasper et al. 2005)() Escitalopram Fluoxetine Placebo 10 20 Yes 8 T8 170 164 180 75 77 76 75±7 75±7 75±7 No 4 3 4 4 0 1 Yes (Kasper et al. 2012)() Escitalopram Placebo 20 No 8 T8 140 71 68.6 74.6 41.6 ±12.6 42.6 ±11.6 No 3 3 0 0 Yes
(Liebowitz et al. 2007)() Desvenlafaxine Placebo 179.0-195.3 No 8 T8 121 117 56 65 41.9±12.5 39.3±12.9 No 21 13 14 7 Yes (Liebowitz et al. 2008)() Desvenlafaxine Desvenlafaxine Placebo 50 100 No 8 T8 151 148 152 62 53 63 43±15 43±13 42±14 No 14 15 5 - - - Yes (Lin et al. 2011)() Sertraline + Placebo 50 Yes 10 T10 20 80 35.2 ±10.0 No 0 1 No (Lineberry et al. 1990)() Bupropion Placebo 286.8 No 6 T6 110 109 - - 41.9 40.8 No 25 8 - - Yes (Lopez-Ibor et al. 2004)() Milnacipran 100 Yes 6 T6 51 74.5 18-70 No 11 - Yes (Lydiard et al. 1997)() Sertraline Placebo 138.6 No 8 T8 132 129 64.4 66.7 41.2 40.2 No 8 3 14 7 Yes (Mao et al. 2008)() Escitalopram Fluoxetine 10 20 Yes 8 T8 118 113 47.5 61.9 37.1±14.1 40.7±13.9 No - - 8 7 Yes (Marchesi et al. 1998)() Fluoxetine 20 Yes 10 T10 67 73.1 43.6± 11.9 No - 1 Yes (Masco et al. 1994)() Bupropion + Placebo 333 No 6 T6 58 50 46.3 No 6 2 Yes (Mathur et al. 2002)() Mirtazapine 22. 9±10.5 No 6 T6 18 - - No 1 - No (Mathur et al. 2005)() Citalopram 36.0 ± 16.7 No 6 T6 20 55 - No 0 0 No
(Mehtonen et al. 2000)() Sertraline Venlafaxine 50-100 75-150 Yes 8 T8 72 75 66.7 65.3 41.0± 10.7 44.1± 11.4 No 8 9 8 5 Yes (Mizukami et al. 2006)() Milnacipran 15-75 No 12 T12 11 81.8 75.2 ± 9.4 Alzheimer's disease - 2 No (Moffaert et al. 1995)() Mirtazapine 24-72 Yes 6 T6 100 69 46.1 ±10.8 No - 13 Yes (Mohamed et al. 2006)() Escitalopram 16.6±4.4 Yes 12 T12 20 30 73.0±4.8 Gad - 1 Yes (Möller et al. 1993)() Paroxetine 30 Yes 6 T6 112 - - No 54 22 No (Möller et al. 2000)() Sertraline 55 Yes 6 T6 115 63.4 47.7± 13.2 No - 0 No (Montgomery et al. 2004)() Escitalopram Venlafaxine 12.1 95.2 Yes 8 T8 146 142 73.3 71.1 49 ±15 47±14 No 11 14 9 4 Yes (Moore et al. 2005)() Citalopram Escitalopram 40 20 Yes 8 T8 142 138 61.9 71.7 46.2± 11.1 44.1± 10.9 No 1 2 3 0 Yes (Munizza et al. 2006)() Sertraline 50-100 Yes 6 T6 60 70 46.9± 10.6 No 3 3 Yes (Nemeroff et al. 2007)() Fluoxetine Venlafaxine Placebo 41±17 142±64 Yes 6 T6 104 102 102 69 65 56 37.9±11.5 40.1± 11.1 40.4± 11.7 No 15 22 14 - - - Yes (Newhouse et al. 2000)() Fluoxetine Sertraline 20-40 50-100 Yes 12 T12 118 116 51.3 63.2 67± 5.9 68± 5.3 No 17 16 - - Yes
(Nierenberg et al. 2007)() Duloxetine Escitalopram Placebo 60 10 Yes 8 T8 273 274 137 63.4 67.9 63.5 41.1±11.6 43.3±13.0 42.5±12.3 No 22 21 9 16 18 5 Yes (Nonacs et al. 2005)() Bupropion 262.5 Yes 8 T8 8 100 31.5 GAD,DAP, anxiety disorder NOS 2 - Yes (Oliè et al. 2007)() Escitalopram 12.1± 4.2 Yes 12 T12 790 70.5 44.5 ±12.5 Anxiety disorders 30 12 Yes (Onder et al. 2003)() Fluoxetine Fluoxetine 20 40 No 12 T12 34 32 50 53.1 35.6± 7.7 34.5± 8.6 No 7 17 - - No (Otsubo et al. 2005)() Fluvoxamine 95.1 Yes 8 T8 36 50 45.3± 13.9 No - 12 No (Ou et al. 2010)() Citalopram Escitalopram 27.6 13.9 No 6 T6 117 115 53.8 58.3 36.4± 12.3 36.7± 12.5 No 4 3 - - No (Pae et al. 2004)() Paroxetine 20-40 Yes 8 T8 52 59.6 43.0± 15.0 No 2 10 Yes (Pae et al. 2008)() Escitalopram 18.3 No 8 T8 17 70.6 43.9± 11.2 No 1 3 Yes (Park et al. 2012)() Escitalopram 9.0 ± 3.8 Yes 12 T12 79 100 49.1±7.6 No - 5 Yes (Patris et al. 1996)() Citalopram Fluoxetine 20 20 Yes 8 T8 173 184 79.2 75.5 44 43 No 8 10 - - Yes (Perahia et al. 2006)() Duloxetine Duloxetine 80 120 Yes 8+26 T8 93 103 66.7 74.8 46.5 ±12.7 44.0± 10.8 No 3 6 1 3 Yes
(Rickels et al. 1985)() Fluoxetine Fluoxetine 20-80 q.d. 20-80 b.i.d. No 6+48 T6 94 94 60 60 37 37 No 14 9 - - No (Rickels et al. 1992)() Paroxetine Placebo 31.5 ± 1.25 Yes 6 T6 55 56 69.2 59.1 43.4 46.0 No 9 5 13 4 No (Roose et al. 2004)() Citalopram Placebo 10-40 No 8 T8 84 90 53.6 62.2 79.8 ± 4.0 79.3 ± 4.7 No 3 5 5 4 Yes (Rosso et al. 2012)() Bupropion Duloxetine 300 120 Yes 6 T6 21 25 71.4 64 46.6 47.6 No 1 0 - - No (Rudolph et al. 1998)() Venlafaxine Venlafaxine Venlafaxine Placebo 75 225 375 No 6 T6 89 89 88 92 40 43 33 32 43.6 43.1 43.8 41.5 No 20 18 12 9 15 16 23 4 Yes (Rudolph et al. 1999)() Fluoxetine Venlafaxine XR Placebo 47 175 Yes 8 T8 103 100 98 73 69 64 40 40 40 No - - - 12 8 6 Yes (Russell et al. 2001)() Sertraline 141.0±59.4 No 6 T6 155 65.1 41.6± 10.6 SUD, anxiety disorders, personality disorders 43 - Yes (Sacchetti et al. 2002)() Paroxetine 20-50 Yes 12 T12 64 64.1 48.7 No 3 3 No (Samuelian et al. 1998)() Venlafaxine 105 Yes 6 T6 52 73.1 47 ± 12 No - 3 Yes
(Schatzberg et al. 2002)() Mirtazapine Paroxetine 25.7 ± 6.7 26.5 ± 5.5 No 8+16 T8 126 120 50 53.3 71.7 ± 5.7 72.0 ± 5.1 No 15 14 39 37 Yes (Schatzberg et al. 2006)() Fluoxetine Venlafaxine Placebo 20-60 37.5-225 Yes 8 T8 100 104 96 56 45 46 71±5 71±5 71±5 No 11 10 4 8 13 4 Yes (Schneider et al. 2003)() Sertraline Placebo 50-100 Yes 8 T8 371 376 54 58 70.0 ± 6.8 69.6 ± 6.5 Alcohol dependence, disthymia, GAD, PD 35 23 38 16 Yes (Schöne et al. 1993)() Fluoxetine Paroxetine 20-60 20-40 Yes 6 T6 52 54 90.4 83.3 73.7 74.3 No 7 5 - - Yes (Schweizer et al. 1994)() Venlafaxine Placebo 83-179 No 6 T6 73 78 71 67 41±13 42±12 No 15 10 19 11 Yes (Sepanjnia et al. 2012)() Citalopram + Placebo 30 Yes 6 T6 20 75 32.7±5.4 Specific phobia 4 - No et al. 2007)() Desvenlafaxine Desvenlafaxine Placebo 200 400 No 8 T8 123 125 125 45.4±11.9 43.4±10.9 46.7±12.1 No - - - 12 7 2 Yes (Sheehan et al. 2009)() Fluoxetine Venlafaxine Placebo 58±13.7 235±74.8 Yes 6 T6 99 94 95 69 48 64 37.8 ±11.1 41.7±12.8 39.9±13.0 No 18 18 8 - - - Yes (Sheikh et al. 2004)() Sertraline Placebo 50-100 No 8 T8 226 232 54.4 53.8 70.1±6.7 70.0±6.6 No 23 17 23 10 Yes
(Shelton et al. 2006)() Sertraline Venlafaxine 50-100 75-225 Yes 8 T8 82 76 46.3 63.2 41.2 ±12.0 37.2±11.6 Personality disorders, other axis I but MD as primary diagnosis 19 14 - - Yes (Shrivastava et al. 1992)() Paroxetine Placebo 22.0-45.5 Yes 6 T6 40 40 27.5 35 38 34.6 No - - 10 6 Yes (Silverstone et al. 1999)() Fluoxetine Venlafaxine XR Placebo 39.9 140.8 Yes 12 T12 121 128 119 59.7 63.9 57.6 43.2± 10.9 41.1± 12.0 41.6± 10.8 Anxiety disorders 30 41 12 17 17 7 Yes (Sir et al. 2005)() Sertraline Venlafaxine XR 105.4±29.5 161.4±44.4 No 8 T8 79 84 72.2 66.7 37.3± 13.5 36.8± 12.4 No 28 23 17 22 Yes (Smith et al. 1990)() Mirtazapine Placebo 18 No 6 T6 50 50 58 58 43 43 No - - 32 8 No et al. 1992)() Paroxetine Placebo 33.8 No 6 T6 39 38 38.5 47.4 44.9 44.6 No 8 2 7 3 Yes (Soares et al. 2010)() Desvenlafaxine Escitalopram 177.2±40.6 18.1±3.9 No 8+26 T8 296 299 100 100 56± 6 56± 6 No 39 33 48 42 Yes (Sögaard et al. 1999)() Sertraline 83.1 Yes 12 T12 99 79.8 42.1± 11.1 No 19 4 Yes (Sonawalla et al. 1999)() Fluvoxamine 143±45 No 12 T12 30 53.3 39.4 ±11.3 No 11 - Yes (Sonawalla et al. 2002)() Fluoxetine 20 No 8 T8 123 49 38.9 ±10.8 Anxiety disorders 21 - No
(Stahl et al. 2010)() Agomelatine Placebo 50 No 8 T8 167 165 63.9 64.5 43.8 ±12.0 43.0±13.1 No 11 10 30 7 Yes (Steen et al. 1997)() Milnacipran 200 No 6+20 T6 30 30 48.1 ±15.2 No 10 - No (Steffens et al. 2001)() Bupropion IR or SR 250-258 No 12 T12 15 - - No 1 - Yes (Stewart et al. 2008)() Duloxetine 74±44 No 8 T8 20 55 35 ± 12 Dysthymia. PD 3 3 Yes (Stuppaeck et al. 1994)() Paroxetine 33.3 No 6 T6 78 70.5 47.5± 11.6 No 8 3 Yes (Taner et al. 2006)() Fluoxetine Reboxetine 20-40 8-10 No 8 T8 21 22 78.4 78.4 36.8± 11.0 36.8± 11.0 No 1 4 - - No (Taragano et al. 1999)() Sertraline 50-100 No 8 T8 469 73 57.4± 13.9 No 9 5 Yes (Thase et al. 1997)() Venlafaxine Placebo 75-225 Yes 8 T8 95 102 63.2 59.8 40±11 42±12 No 33 15 26 11 Yes et al. 1997)() Fluoxetine 37.2 No 6 T6 106 72 42.9±12.1 No 22 18 Yes (Thase et al. 2002)() Citalopram 23.9 No 6 T6 61 52.5 43.0±11.9 No 1 5 No (Thase et al. 2006)() Bupropion Venlafaxine 299.6±77.1 149.8±41.3 No 12 T12 168 174 56 64 37.1± 12.3 37.4± 11.6 No - - 2 12 Yes (Tollefson et al. 1994)() Fluoxetine 20-40 No 8 T8 62 71 40.1± 11.7 No 19 - Yes
(Tollefson et al. 1995)() Fluoxetine Placebo 20 Yes 6 T6 335 336 53.7 55.4 67.7±5.7 67.7±5.7 No 61 42 - - Yes et al. 2011)() Duloxetine 83.5 Yes 12 T12 27 40.7 63.6 ±10.9 No 1 - Yes (Tourian et al. 2009)() Duloxetine Desvenlafaxine Desvenlafaxine Placebo 60 50 100 No 8 T8 157 148 150 160 66 69 66 58 39±12 41±13) 39±12 39±13 No 29 16 21 5 23 9 17 4 Yes (Tzanakaki et al. 2000)() Fluoxetine Venlafaxine 20-60 75-225 Yes 6 T6 54 55 83.3 74.5 49±10 47±11 No 1 7 - - Yes (Tzeng et al. 2009)() Mirtazapine 33.2 No 7 T7 58 55.2 47.7 ±16.6 SUD - 4 No (Urbina et al. 1999)() Fluoxetine 20 Yes 6 T6 20 95 34.4± 1.8 No 5 - No (Vanderkooy et al. 2002)() Bupropion Sertraline Venlafaxine Paroxetine 143.3±25.8 105.4±217.5 81.4±58.4 18.7±6.1 No 8 T8 15 37 62 55 73.3 81.1 61.3 38.2 41.1± 8.8 39.5± 11.4 40.8± 11.2 38.1± 11.3 No 5 5 16 7 3 12 17 16 No (Ventura et al. 2007)() Escitalopram Sertraline 10 113.6 Yes 8 T8 104 107 54.8 59.8 40.6± 13.7 38.1± 11.5 No 14 18 12 6 Yes (Versiani et al. 1999)() Fluoxetine 20 No 8 T8 77 - - No 3 11 No (Versiani et al. 2000)() Reboxetine 10 Yes 6 T6 28 46.4 41.7 No 7 - Yes
Placebo 28 50 40.0 0 - (Versiani et al. 2005)() Fluoxetine Mirtazapine 20-40 10-60 Yes 8 T8 147 145 69 74 47 43 No 13 7 14 20 Yes (Volonteri et al. 2010)() Duloxetine 74.0± 24.6 No 12 T12 45 36 59.6± 12.8 Personality disorders, SUD 4 4 No (Volpe et al. 2008)() Dluoxetine 60 Yes 8 T8 30 93.3 41 ± 8 No 9 8 Yes (Waintraub et al. 2002)() Paroxetine + Placebo 20 Yes 12 T12 139 66.7 41 No 0 2 No (Wakeno et al. 2008)() Milnacipran Paroxetine 60.0± 16.9 27.8± 7.5 Yes 6 T6 30 27 43.3 51.9 49.3± 12.6 48.3± 15.0 No - - 3 1 Yes (Weihs et al. 2000)() Bupropion Paroxetine 197± 53 22 ± 7 No 6 T6 48 52 54 60 69.2 71.0 No 6 8 3 14 Yes (Weihs et al. 2002)() Bupropion 277± 30.9 Yes 8+44 T8 816 68 39.4 No 131 - Yes (Weisler et al. 1994)() Bupropion 279 No 6 T6 62 53.2 40.2 No 9 5 Yes (Wheatley et al. 1998)() Fluoxetine Mirtazapine 23.8± 3.8 Yes 6 T6 66 66 59 55 47.5 ±14.8 47.2 ±15.3 No - - 9 12 Yes (Wijkstra et al. 2010)() Venlafaxine 372.3± 14.2 Yes 7 T7 39 43.6 49.5± 12.0 No 1 1 Yes (Wohlreich et al. 2004)() Duloxetine 80-120 Yes 52 T8 101 71.3 71.9± 5.4 No 15 22 Yes (Wohlreich et al. 2007)() Duloxetine 91.9 Yes 6+104 T6 128 61.8 42.6±13.3 No 9 6 Yes