University of Florida, College of Medicine GMS 6622 - Mitochondrial Biology in Aging and Disease Department of Aging and Geriatric Research Semester: Fall 2018 Time: Thursday’s for 2 hours from 3:00PM – 5:00PM (14 classes) Dates: Aug. 23, 30 Sep, 6, 13, 20, 27 Oct. 4, 11, 18, 25 (Midterm) Nov. 1, 8, 15, 29 Dec. 6 (Final) Room: ARB R2-265 Credits: 2 credits Office Hours: By appointment (see email addresses below) Course Directors: Christiaan Leeuwenburgh, PhD and Jonathon Burman, PhD and jonathon.burman@ufl.edu Contact Information: Teresa Richardson Aging and Geriatric Research College of Medicine- University of Florida trichar@ufl.edu Phone 352-294-5851 The overall goal of this class is to introduce: 1) the structure and function of mitochondria; 2) mitochondria in aging and disease; 3) assessments for mitochondrial function and genetic variance. Topics will include mitochondrial genetics, biogenesis, bioenergetics, dynamics, metabolic disorders, mitophagy, genetic diseases, and aging. In class, we will discuss the readings assigned and explore the topic in more detail by student presentations. The meeting will begin with a brief introduction to the topic by the lecturer. This will be followed by presentations of the assigned readings, in PowerPoint format, by students. Usually these papers will be assigned on a weekly basis to make sure we have the most up-to-date literature and that we also incorporate individual interest in the readings. By the end of the course, you should have a solid foundation in a number of areas related to research on aging and also acquire the skills needed to seek out and learn more about this exciting field. 1) Catalog description GMS: The overall goal of this class is to introduce: 1) the basic biology of mitochondria, 2) mitochondria in aging and disease, and 3) assessments of mitochondrial function and genetic variance.
2) Course summary of topics to be covered and tentative Lecturers. Date Session Topics Faculty Week 1 8/23 Structure and function of mitochondria C. Leeuwenburgh Week 2 8/30 Mitochondrial bioenergetics and aging Russ Hepple Week 3 9/6 Mitochondria and eye disease John Ash Week 4 9/13 Mitochondria and hearing loss Shinichi Someya Week 5 Week 6 9/20 9/27 Mitophagy Mitochondria in heart disease Jonathon Burman Christina Pacak Week 7 10/4 Mitochondria: replication, import, mutation, and deletion Al Lewin Week 8 10/11 Mitochondrial genetic diseases Al Lewin Week 9 10/18 Mitochondrial dynamics Jonathon Burman Week 10 10/25 Midterm Christiaan Leeuwenburgh Week 11 11/1 Assessments of mitochondrial function by respirometry: Part 1 Steffi Wohlgemuth Week 12 11/8 Assessments of mitochondrial function by respirometry: Part 2 Steffi Wohlgemuth Week 13 11/15 Assessment of mitochondria by microscopy: Principle and theory of optical assessment and hands-on Sung Min Han Week 14 11/29 Part 2 Microscopy hands-on Evaluations/Pre-Review Final Sung Min Han Jonathan Burman Week 15 12/6 Final Jonathon Burman Christiaan Leeuwenburgh 3) Text: No text is required. Weekly assigned scientific journal articles will be used for reading, presentation and discussion material. Specifically, on a weekly base, original research papers will be presented from Journals with a high impact Factors such as Cell, Nature, Science, Neuron, PNAS, JCB, JBC, and JCI on topics to be presented for that week. Original research papers will be selected by the Professors and publications will be selected from papers published in the past year.