Appendix B: Where to find valid information Manufacturers and importers can classify hazardous chemicals through collection, evaluation and review of valid information on the hazards of a chemical. Information may be available: from epidemiological data and acknowledged experiences on the effects of chemicals on humans; from tests that are conducted according to internationally recognised scientific principles published in scientific journal articles; on labels and within SDS; or on databases or lists of chemicals such as HSIS (see Table 2 below). Before using the information from any of the sources listed below you need to be aware of the limitations of the data. For example, the HSIS database does not contain information for all hazard endpoints for all chemicals. Other information sources should be considered. Table 1: Relevant databases for information on hazardous chemical classifications Name: Maintained by: Link: Contains: HSIS (Hazardous Substances Information System) Australia Information on substances that have been classified in accordance with the Approved Criteria for Classifying Hazardous Substances [NOHSC:1008 (2004] 3rd Edition Note this database does not contain comprehensive information for all hazard endpoints for all chemicals. ESIS (European chemical Substances Information System) EU Information on chemicals classified in accordance with the GHS for those classes and categories captured by European regulations (refer to Annex I). CCID (Chemical Classification and Information Database) New Zealand Information on chemicals classified in accordance with the GHS under the Hazardous Substances and New Organisms (HSNO) regulations. CSI (Chemical Sampling Information) United States Hazard data on a large number of chemical substances that may be encountered in industrial hygiene investigations. eChemPortal OECD Information on physical and chemical
Liquefied Gas Gases under pressure – Dissolved Gas Gas under pressure – Refrigerated Liquefied Gas H281 – Contains refrigerated gas; may cause cryogenic burns or injury Division 2.1 Flammable Gases Gas Flammable Gases Category 1 Flammable Aerosol Category 1 Flammable Aerosol Category 2 H220 – Extremely flammable gas H222 – Extremely flammable aerosol H223 – Flammable aerosol Division 2.2 Non-flammable, non-toxic Gases Gas Liquid/Gas Gas Liquid/Gas Compressed Gas, Liquefied Gas & Dissolved Gas Refrigerated Liquefied Gas H280 – Contains gas under pressure; may explode if heated H281 – Contains refrigerated gas; may cause cryogenic burns or injury Divisions 2.2 / Sub-risk. 5.1 Oxidising Gases, Non-flammable, non-toxic Gases, Sub-risk Oxidising Substances Gas Oxidising Gases Category 1 Gases under pressure not otherwise specified H270 – May cause or intensify fire; Oxidiser H280 – Contains gas under pressure; may explode if heated Division 2.3 Toxic Gases Gas Acute Inhalation Toxicity (gas) Category 1 Acute Inhalation Toxicity (gas) Category 2 Acute Inhalation Toxicity (gas) Category 3 H330 – Fatal if inhaled H330 – Fatal if inhaled H331 – Toxic if inhaled
Skin Corrosion Sub-category 1A – 1C H314 – Causes severe skin burns and eye damage Class 3: PG I Flammable Liquids Liquid Flammable Liquids Category 1 H224 – Extremely flammable liquid and vapour Class 3: PG II Flammable Liquids Liquid Flammable Liquids Category 2 H225 – Highly flammable liquid and vapour Class 3: PG III Flammable Liquids Liquid Flammable Liquids Category 3 H226 – Flammable liquid and vapour Division 4.1: PG II Flammable Solids Solid Flammable Solids Category 1 H228 – Flammable solid Division 4.1: PG III Flammable Solids Solid Flammable Solids Category 2 H228 – Flammable solid Division 4.1: Self-reactive Substance Type A Solid Self-reactive Substances and Mixtures: Type A H240 – Heating may cause an explosion Division 4.1: Self-reactive Substance Type B Solid Self-reactive Substances and Mixtures: Type B H241 – Heating may cause a fire or explosion Division 4.1: Self-reactive Substance Type C Solid Self-reactive Substances and Mixtures: Type C H242 – Heating may cause a fire Division 4.1: Self-reactive Substance Type D Solid Self-reactive Substances and Mixtures: Type D H242 – Heating may cause a fire Division 4.1: Self-reactive Substance Type E Solid Self-reactive Substances and Mixtures: Type E H242 – Heating may cause a fire Division 4.1: Self-reactive Substance Type F Solid Self-reactive Substances and Mixtures: Type F H242 – Heating may cause a fire Division 4.1: Self-reactive Substance Type G Solid Self-reactive Substances and Mixtures: Type G None Division 4.2: PG I Pyrophoric Substances Liquid Pyrophoric Liquids Category 1 H250 – Catches fire spontaneously if exposed to air Division 4.2: PG I Pyrophoric Substances Solid Pyrophoric Solids Category 1 H250 - Catches fire spontaneously if exposed to air Division 4.2: PG II Self-heating Substances and Mixtures H251 – Self-heating; may catch fire
Self-heating Substances Category 1 Division 4.2: PG III Self-heating Substances Self-heating Substances and Mixtures Category 2 H252 – Self-heating in large quantities; may catch fire Division 4.3: PG I Substances which in contact with water emit flammable gases Substances which, in contact with water, emit flammable gases Category 1 H260 – In contact with water releases flammable gases, which may ignite spontaneously Division 4.3: PG II Substances which in contact with water emit flammable gases Substances which, in contact with water, emit flammable gases Category 2 H261 – In contact with water releases flammable gases Division 4.3: PG III Substances which in contact with water emit flammable gases Substances which, in contact with water, emit flammable gases Category 3 H261 – In contact with water releases flammable gases Division 5.1: PG I Oxidising Substances Liquid Solid Oxidising Liquids Category 1 Oxidising Solids Category 1 H271 – May cause fire or explosion; Strong oxidiser Division 5.1: PG II Oxidising Substances Liquid Solid Oxidising Liquids Category 2 Oxidising Solids Category 2 H272 – May intensify fire; Oxidiser Division 5.1: PG III Oxidising Substances Liquid Solid Oxidising Liquids Category 3 Oxidising Solids Category 3 H272 – May intensify fire; Oxidiser Division 5.2: Type A Organic Peroxides Organic Peroxides Type A H240 – Heating may cause an explosion Division 5.2: Type B Organic Peroxides Organic Peroxides Type B H241 – Heating may cause a fire or explosion Division 5.2: Type C Organic Peroxides H242 – Heating may cause a fire
Organic Peroxides Type C Division 5.2: Type D Organic Peroxides Organic Peroxides Type D H242 – Heating may cause a fire Division 5.2: Type E Organic Peroxides Organic Peroxides Type E H242 – Heating may cause a fire Division 5.2: Type F Organic Peroxides Organic Peroxides Type F H242 – Heating may cause a fire Division 5.2: Type G Organic Peroxides Organic peroxides Type G None Division 6.1: PG I Toxic Substances Dust/mist/ vapour Acute Oral Toxicity Category 1 Acute Dermal Toxicity Category 1 Acute Inhalation Toxicity Category 1 H300 – Fatal if swallowed H310 – Fatal in contact with skin H330 – Fatal if inhaled Division 6.1: PG II Toxic Substances Dust/mist/ vapour Acute Oral Toxicity Category 2 Acute Dermal Toxicity Category 2 Acute Inhalation Toxicity Category 2 H300 – Fatal if swallowed H310 – Fatal in contact with skin H330 – Fatal if inhaled Division 6.1: PG III Toxic Substances Dust/mist/ vapour Acute Oral Toxicity Category 3 Acute Dermal Toxicity Category 3 Acute Inhalation Toxicity Category 3 H301 – Toxic if swallowed H311 – Toxic in contact with skin H331 – Toxic if inhaled
E – Danger: Explosive; R3 - Extreme risk of explosion by shock, friction, fire or other sources of ignition No translation possible. Reclassify utilising GHS Criteria for Explosives. O – Danger: Oxidising; R7 - May cause fire Organic Peroxides Type C and D H242 - Heating may cause a fire Organic Peroxides Type E and F H242 - Heating may cause a fire O – Danger: Oxidising; R8 - Contact with combustible material may cause fire Gas Oxidising Gases Category 1 H270 - May cause or intensify fire; Oxidiser O – Danger: Oxidising; R8 - Contact with combustible material may cause fire Liquid, solid No translation possible. Reclassify utilising GHS criteria for Oxidising Liquids or Oxidising Solids. O – Danger: Oxidising; R9 - Explosive when mixed with combustible material Liquid Oxidising Liquids Category 1 H271 - May cause fire or explosion; Strong oxidiser O – Danger: Oxidising; R9 - Explosive when mixed with combustible material Solid Oxidising Solids Category 1 H271 - May cause fire or explosion; Strong oxidiser R10 - Flammable Liquid Flammable liquids category 1: if flashpoint <23ºC and initial boiling point ≤ 35ºC H224 – Extremely flammable liquid and vapour Flammable liquids category 2: if flashpoint <23ºC and initial boiling point >35ºC H225 – Highly flammable liquid and vapour Flammable liquids category 3: if flashpoint ≥ 23ºC H226 – Flammable liquid and vapour F - Danger: Highly Flammable; R11 - Highly flammable Liquid Flammable liquids category 1: if initial boiling point ≤ 35ºC H224 – Extremely flammable liquid and vapour
Xn - Harmful; R20 - Harmful by inhalation Dust/mist Acute Toxicity Category 4 H332- Harmful if inhaled (1) Xn - Harmful; R21 - Harmful in contact with skin Acute Toxicity Category 4 H312 - Harmful in contact with skin (1) Xn - Harmful; R22 - Harmful if swallowed Acute Toxicity Category 4 H302 - Harmful if swallowed (1) T - Toxic; R23 - Toxic by inhalation Gas Acute Toxicity Category 3 H331 - Toxic if inhaled (1) (2) T - Toxic; R23 - Toxic by inhalation Vapour Acute Toxicity Category 2 H330 - Fatal if inhaled T - Toxic; R23 - Toxic by inhalation Dust/mist Acute Toxicity Category 3 H331 - Toxic if inhaled (1) T - Toxic; R24 - Toxic in contact with skin Acute Toxicity Category 3 H311 - Toxic in contact with skin (1) T - Toxic; R25 - Toxic if swallowed Acute Toxicity Category 3 H301 - Toxic if swallowed (1) T+ - Very Toxic; R26 - Very toxic by inhalation Gas Acute Toxicity Category 2 H330 - Fatal if inhaled (1) (2) T+ - Very Toxic; R26 - Very toxic by inhalation Vapour Acute Toxicity Category 1 H330 - Fatal if inhaled T+ - Very Toxic; R26 - Very toxic by inhalation Dust/mist Acute Toxicity Category 2 H330 - Fatal if inhaled (1) T+ - Very Toxic; R27 - Very toxic in contact with skin Acute Toxicity Category 1 H310 - Fatal in contact with skin T+ - Very Toxic; R28 - Very Toxic if swallowed Acute Toxicity Category 2 H300 - Fatal if swallowed (1) R33 - Danger of cumulative effects Translation as per R48 – Danger of serious damage to health by prolonged exposure (by inhalation, contact with skin or swallowed (R20/21/22)) see below. C - Corrosive; Skin Corrosion H314 - Causes severe skin burns and eye (3)
R34 - Causes burns Sub-category 1B damage C - Corrosive; R35 - Causes severe burns Skin Corrosion Sub-category 1A H314 - Causes severe skin burns and eye damage Xi – Irritant; R41 - Risk of serious damage to eyes Eye Damage Category 1 H318 - Causes serious eye damage Xi - Irritant; R36 - Irritating to eyes Eye Irritation Category 2A H319 - Causes serious eye irritation Xi - Irritant; R37 - Irritating to respiratory system Specific Target Organ Toxicity Category 3 H335 - May cause respiratory irritation Xi - Irritant; R38 - Irritating to skin Skin irritation Category 2 H315 - Causes skin irritation T - Toxic; R39 – Danger of very serious irreversible effects R23 – Toxic by inhalation Specific Target Organ Toxicity - Single Exposure Category 1 H370 - Causes damage to organs (4) T - Toxic; R39 – Danger of very serious irreversible effects R24 – Toxic in contact with skin Specific Target Organ Toxicity - Single Exposure Category 1 H370 - Causes damage to organs (4) T - Toxic; R39 – Danger of very serious irreversible effects R25 – Toxic if swallowed Specific Target Organ Toxicity - Single Exposure Category 1 H370 - Causes damage to organs (4) T+ - Very Toxic; R39 – Danger of very serious irreversible effects R26 – Very toxic by inhalation Specific Target Organ Toxicity - Single Exposure Category 1 H370 - Causes damage to organs (4) T+ - Very Toxic; R39 – Danger of very serious Specific Target Organ Toxicity - Single Exposure H370 - Causes damage to organs (4)
irreversible effects R27 – Very toxic in contact with skin Category 1 T+ - Very Toxic; R39 – Danger of very serious irreversible effects R28 – Very toxic if swallowed Specific Target Organ Toxicity - Single Exposure Category 1 H370 - Causes damage to organs (4) Xn - Harmful; R68 – Possible risk of irreversible effects R20 – Harmful by inhalation Specific Target Organ Toxicity - Single Exposure Category 2 H371 - May cause damage to organs (1) (4) Xn - Harmful; R68 – Possible risk of irreversible effects R21 – Harmful in contact with skin Specific Target Organ Toxicity - Single Exposure Category 2 H371 - May cause damage to organs (1) (4) Xn - Harmful; R68 – Possible risk of irreversible effects R22 – Harmful if swallowed Specific Target Organ Toxicity - Single Exposure Category 1 H371 - May cause damage to organs (1) (4) R42 – May cause sensitisation by inhalation Respiratory Sensitisation Category 1 H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled R43 – May cause sensitisation by skin contact Skin Sensitisation Category 1 H317 - May cause an allergic skin reaction Xn - Harmful; R48 – Danger of serious damage to health by prolonged exposure R20 – Harmful by inhalation Specific Target Organ Toxicity - Repeated Exposure Category 2 H373 - May cause damage to organs (1) (4) Xn - Harmful; R48 – Danger of serious damage to health by Specific Target Organ Toxicity - Repeated Exposure Category 2 H373 - May cause damage to organs (1) (4)
prolonged exposure R21 – Harmful in contact with skin Xn - Harmful; R48 – Danger of serious damage to health by prolonged exposure R22 – Harmful if swallowed Specific Target Organ Toxicity - Repeated Exposure Category 2 H373 - May cause damage to organs (1) (4) T - Toxic; R48 – Danger of serious damage to health by prolonged exposure R23 – Toxic by inhalation Specific Target Organ Toxicity - Repeated Exposure Category 1 H372 - Causes damage to organs (4) T - Toxic; R48 – Danger of serious damage to health by prolonged exposure R24 – Toxic in contact with skin Specific Target Organ Toxicity - Repeated Exposure Category 1 H372 - Causes damage to organs (4) T - Toxic; R48 – Danger of serious damage to health by prolonged exposure R25 – Toxic if swallowed Specific Target Organ Toxicity - Repeated Exposure Category 1 H372 - Causes damage to organs (4) R64 – May cause harm to breastfed babies Effects on or via lactation H362 - May cause harm to breast-fed children Xn - Harmful; R65 – Harmful: May cause lung damage if swallowed Aspiration hazard Category 1 H304 - May be fatal if swallowed and enters airways R67 – Vapours may cause drowsiness and dizziness Specific Target Organ Toxicity - Repeated Exposure Category 3 H336 - May cause drowsiness and dizziness
Carcinogen Category 1 T - Toxic; R45 – May cause cancer Carcinogenicity Category 1A H350 - May cause cancer (5) Carcinogen Category 2 T - Toxic; R45 – May cause cancer Carcinogenicity Category 1B H350 - May cause cancer (5) Carcinogen Category 1 T - Toxic; R49 – May cause cancer by inhalation Carcinogenicity Category 1A H350 - May cause cancer (5) Carcinogen Category 2 T - Toxic; R49 – may cause cancer by inhalation Carcinogenicity Category 1B H350 - May cause cancer (5) Carcinogen Category 3 Xn - Harmful; R40 – Limited evidence of carcinogenic effect Carcinogenicity Category 2 H351 - Suspected of causing cancer Mutagen Category 1 T - Toxic; R46 – May cause heritable genetic damage Mutagenicity Category 1A H340 - May cause genetic defects Mutagen Category 2 T - Toxic; R46 – May cause heritable genetic damage Mutagenicity Category 1B H340 - May cause genetic defects Mutagen Category 3 Xn - Harmful; R68 – Possible risk of irreversible effects Mutagenicity Category 2 H341 - Suspected of causing genetic defects Reproductive Toxin Category Toxic to Reproduction H360 - May damage fertility or the unborn child (6)
1 T - Toxic; R60 – May impair fertility R61 – May cause harm to the unborn child Category 1A Reproductive Toxin Category 2 T - Toxic; R60 – May impair fertility R61 – May cause harm to the unborn child Toxic to Reproduction Category 1B H360 - May damage fertility or the unborn child (6) Reproductive Toxin Category 3 Xn - Harmful; R62 – Possible risk of impaired fertility R63 – Possible risk of harm to the unborn child Toxic to Reproduction Category 2 H361 - Suspected of damaging fertility or the unborn child (6) N – Dangerous for the Environment; R50 – Very toxic to aquatic organisms Acute Aquatic Toxicity Category 1 H400 - Very toxic to aquatic life (10) N – Dangerous for the Environment; R50 – Very toxic to aquatic organisms R53 – May cause long term adverse effects in the aquatic environment Acute Aquatic Toxicity Category 1 H400 - Very toxic to aquatic life (7) (9) (10) Chronic Aquatic Toxicity Category 1 H410 - Very toxic to aquatic life with long lasting effects (7) (9) (10) N – Dangerous for the Environment; Acute Aquatic Toxicity Category 2 H401 - Toxic to aquatic life (7) (9) (10)