IIA 1.3 Common name DACO 2.4 / OPPTS 830.1550 As proposed or approved by ISO; otherwise, industry standard IIA 1.4 Chemical name DACO 2.5 / OPPTS 830.1550 IUPAC: As approved by ISO (may be multiple versions including Preferred IUPAC Name [PIN]) CAS: As approved by ISO IIA 1.5 Manufacturer’s codes and names IIA 1.5.1 Manufacturer’s development code number(s) DACO 2.3.1 / OPPTS 830.1550 Development code number(s) IIA 1.5.2 Trade names DACO 2.3 / OPPTS 830.1550 Proposed trade name in each country IIA 1.6 CAS and CIPAC numbers DACO 2.6 / OPPTS 830.1550 CAS number: CIPAC number: If assigned IIA 1.7 Molecular and structural formula, molecular mass DACO 2.7, 2.8, 2.9 / OPPTS 830.1550 Molecular formula: Structural formula: Molecular mass: g/mol IIA 1.9.1 Guarantee of active ingredient (excluding inactive isomers) DACO 2.12.1 / OPPTS 830.1550 Nominal guarantee (or minimum if applicable) of active ingredient in % IIA 1.12 Other/special studies DACO 2.16 If applicable
Annex IIA Point Test or property Guideline and method Test material purity and specification Study findings and applicant comments Reviewer conclusions Data 1 GLP Y/N Reference IIA 2.1.1 Melting point / melting range OECD 102, DACO 2.14.4, OPPTS 830.7200 Lot number, purity The melting point of the pure active ingredient (PAI) was determined to be …C, using … The melting point of the technical grade active ingredient (TGAI) was determined to be …C, using … Applicant report # PMRA # MRID # IIA 2.1.2 Boiling point / boiling range OECD 103, DACO 2.14.5, OPPTS 830.7220 The boiling point of the PAI was determined to be …C, using … The boiling point of the TGAI was determined to be …C, using … IIA 2.1.3 Temperature of decomposition or sublimation OECD 102 The decomposition temperature of the PAI was determined to be …C, using … The decomposition temperature of the TGAI was determined to be …C, using … OR Not required by PMRA or EPA IIA 2.2 Relative density / density OECD 109, DACO 2.14.6, OPPTS 830.7300 The (relative) density of the PAI was determined to be … at …C, using … The (relative) density of the TGAI was determined to be … at …C, using … IIA 2.3.1 Vapour pressure OECD 104, DACO 2.14.9, OPPTS 830.7950 The vapour pressure of the PAI was determined using … The results are reported below: temperature (C) vapour pressure (Pa) IIA 2.3.2 Henry’s law constant Calculated using solubility and vapour pressure Refer to the environmental fate review. N/A
IIA 2.4.1 Appearance: colour Visual assessment, DACO 2.14.1, OPPTS 830.6302 The PAI is … The TGAI is … IIA 2.4.1 Appearance: physical state Visual assessment, DACO 2.14.2, OPPTS 830.6303 The PAI is a … The TGAI is a … IIA 2.4.2 Appearance: odour Olfactory assessment, DACO 2.14.3, OPPTS 830.6304 The odour of the PAI is … The odour of the TGAI is … IIA 2.5.1.1 + 2.5.1.5 UV/Vis spectrum of active substance / Molecular extinction coefficient of active substance OECD 101, DACO 2.14.12, OPPTS 830.7050 UV absorption of the PAI was measured using … conditions max (nm) (L/mol.cm) acidic basic neutral IIA 2.5.1.2 IR spectrum of active substance DACO 2.13.2 The IR spectrum for the PAI was obtained using … The interpretation of the IR bands was reported in … and is consistent with the structure.
IIA 2.5.1.3 NMR spectrum of active substance DACO 2.13.2 The 13C-NMR and 1H-NMR spectra were obtained using …. Assignments of chemical shifts were reported in … and are consistent with the structure. IIA 2.5.1.4 MS spectrum of active substance DACO 2.13.2 The mass spectrum for the PAI was obtained using … The interpretation of the signals was reported in … and is consistent with the structure. IIA 2.5.1.6 Optical purity of active substance / optical isomer ratio The ratio of the enantiomers in the TGAI was determined to be …, obtained using … IIA 2.5.2 Spectra for relevant impurities (i.e. of toxicological concern) DACO 2.13.2 Refer to confidential section of this review IIA 2.6 Solubility in water OECD 105, DACO 2.14.7, OPPTS 830.7840, OPPTS 830.7860 The water solubility of the active ingredient was determined using … The results are reported below: pH solubility (units) at …°C
IIA 2.7 Solubility in organic solvents OECD 105, DACO 2.14.8, OPPTS 830.1000, CIPAC MT 181 The solubility of the active ingredient in various organic solvents was determined using … The results are reported below: solvent solubility (units) at …°C IIA 2.8 Partition coefficient / water including effect of pH (4 to 10) OECD 107, DACO 2.14.11, OPPTS 830.7550, 830.7560, 830.7570 The Kow of the active ingredient was determined to be … using … The log Kow was calculated to be … If applicable: pH Kow log Kow IIA 2.9.1 Hydrolysis rate at pH 4, 7, and 9 under sterile conditions in the absence of light Refer to the environmental fate review. IIA 2.9.2 Direct Refer to the environmental fate review. IIA 2.9.3 Quantum yield of direct Refer to the environmental fate review.
IIA 2.14 Surface tension EC A.5, OECD 115 Not required by PMRA or EPA IIA 2.15 Oxidising and reducing properties / chemical incompatibility EC A.17, OPPTS 830.6314 Not required by PMRA for technical materials; required by EPA IIA 2.16 pH DACO 2.14.15, OPPTS 830.7000, CIPAC MT 75 The pH of (a 1% dilution of) the PAI was determined as … The pH of (a 1% dilution of) the TGAI was determined as … IIA 2.17.1 Storage stability DACO 2.14.14, OPPTS 830.6317 The TGAI was stored for … (state conditions / duration) in … (state container material). Results at regular intervals (…) demonstrated that … Required by PMRA only for ISPs. IIA 2.17.2 Stability (temperature, metals) DACO 2.14.13, OPPTS 830.6313, CIPAC MT 46 The TGAI is stable upon exposure to …