9.2 Distribution 44 9.3 Metabolism 46 9.4 Elimination and excretion 47 9.5 Summary 49 10. MMT 50 10.1 Acute toxicity 50 10.2 Irritation and corrosivity 52 10.2.1 Skin 52 10.2.2 Eye 53 10.3 Sensitisation 53 10.4 Repeated dose toxicity 54 10.5 Reproductive toxicity 55 10.6 Genotoxicity 57 10.7 Carcinogenicity 58 10.8 Pulmonary toxicity 58 10.9 Neurotoxicity 61 10.10 MMT combustion products 63 10.11 Human exposure 65 11. 66 11.1 Kinetics and metabolism 66 11.2 health effects 68 11.3 Effects in animals 70 12. 73 12.1 Physicochemical hazards 73 12.2 Health hazards 73 12.2.1 toxicity 73 12.2.2 Irritation and corrosive effects 74 12.2.3 Sensitising effects 74 12.2.4 Effects from repeated or prolonged exposure 74 12.2.5 Reproductive effects 75 12.2.6 Genotoxicity 76 12.2.7 Carcinogenicity 76 13. 77 13.2 Terrestrial animals 78 13.2.1 MMT 78 13.2.2 Manganese 78 HAZARD
1.27 to 9.99 mg/L (growth and mortality). The toxicity data have been summarised in Table 19. Table 19. Summary of freshwater fish toxicity data for manganese Species Endpoint Result (mg/L) Reference Fathead minnows Pimphales promelas 96-hour LC50 33.8 Kimball (1978), as by USEPA, 2000 Longfin dace Agosia chrysogaster 96-hour LC50 130 (1978), as cited by USEPA, 2000 Silverside Basilichthys australis 96-hour LC50 >50 Trucco et al. (1991), as cited by USEPA, 2000 Giant gourami Colisa fasciata 24-hour LC50 48-hour LC50 72-hour LC50 96-hour LC50 478 345 324 295 Nath and Kumar (1987), as cited by USEPA, 2000 Nath and Kumar (1987), as cited by USEPA, 2000 Nath and Kumar (1987), as cited by USEPA, 2000 Nath and Kumar (1987), as cited by USEPA, 2000 96-hour LC50 1040 Agrawal and Srivastava (1980), as cited in USEPA, 2000 Table 19. Summary of freshwater fish toxicity data for manganese (cont.) Species Endpoint Result (mg/L) Reference Medaka Oryzias latipes 24-hour LC50 48-hour LC50 >1000 >1000 Tsuji et al. (1986), as cited by USEPA, 2000 Tsuji et al., 1986, as cited by USEPA, 2000 Rainbow Oncorhynchus mykiss 4-hour LC01 4-hour LC10 0.39 0.96 Birge et al., 1981 as cited by USEPA, 2000 Birge et al., 1981 as cited by USEPA, 2000 28-day LC50 2.91 et al., 1980 as cited by USEPA, 2000 100-day MATC a 0.77 -1.53 b Goettl and Davies, 1978 as cited by USEPA, 2000 Goldfish Carssius auratus 7-day LC50 8.22 1978 as cited by USEPA, 2000 Fathead Minnow Pimphales promelas 8-day LC50 34.6 Kimball, 1978 as cited by USEPA, 2000
If products containing multiple of additive are produced for consumer use, it is recommended also that where possible these should be packaged in containers with a measuring capacity or ideally with an automatic measuring and dispensing capacity. Appropriate consideration of the light sensitivity of MMT would also be required. Emergency procedures Any spills of product containing MMT should not be allowed to enter stormwater, sewers or natural waters.
CNS effects 8/8 First Aid Statements for ingestion, inhalation, skin and eye exposure 8/8 One MSDS did not contain advice to contact a doctor following eye exposure. Precautions For Use Personal Protective Equipment 8/8 Correct atmospheric exposure standard for MMT of 0.2 mg/m3 (TWA) 7/8 Most MSDS refer to the ACGIH standard for MMT (identical to that of NOHSC). Skin notation explained 2/8 Skin notation was present in 7 MSDS but only 2 provided an accompanying explanation. Contact Point Direct telephone number 7/8 Three of these 7 MSDS containing a Contact Point referred only to the Australian Poisons Information Centre.