PURITY OF THE CHEMICAL Degree of Purity: 96 – 98% Toxic or Hazardous Impurities: Chemical name: o-xylene CAS No.: 1330-30-7 Weight percentage: < 0.1% Toxic or hazardous properties: toxic by ingestion an inhalation an experimental teratogen (1) explosive in the form of vapour when exposed to heat or flame; when heated to decomposition acrid smoke and irritating fumes are given off (1) Impurities: Chemical name: 5,7,5’,7’-tetra-terbutyl-3-(3,4-dimethylphenyl)- 3H,3’H-[3,3’H-]bi-benzofuranyl-2,2’-dione CAS No.: - Weight percentage: 0.7% Unknown Impurities (> 1% by weight): 1.4% (seven detected) Additives/Adjuvants: none USE, VOLUME AND FORMULATION The notified chemical will not be manufactured in Australia. CG 33-1136/TKA will be imported in powder form, at a concentration `of approximately 98% as HP 136, and will be used as an additive to impart improved resistance to oxidation and better flow characteristics. The applications will be mainly for polyolefins and to a lesser extent for polycarbonates, styrenics, elastomers and adhesives. The notified chemical will also be imported as a component of the Irganox HP range of products, which typically contain approximately 15% by weight of HP-136. It is estimated that 2 to 5 tonnes per annum of the notified chemical will be imported in the
Mortality: Morphological findings: Test method: LD50: None None similar to OECD guidelines (3) > 2 000 mg/kg Result: the notified chemical was of low toxicity when administered orally in a limit test in rats 9.1.2 Dermal Toxicity (4) Species/strain: rat/SPF bred Number/sex of animals: 5/sex Observation period: 14 days Method of administration: a dose of 2 000 mg/kg was applied in 0.5% (w/v) carboxymethylcelulose and 0.1% (w/v) aqueous polysorbate 80 to an intact skin site; the site was covered with a semi-occlusive dressing; 24 hours the dressing and residual test material were removed Clinical observations: there were no signs of systemic toxicity Mortality: None Morphological findings: None Test method: similar to OECD guidelines (3) LD50: > 2 000 mg/kg Result: the notified chemical was of low acute toxicity when administered dermally to rats in a limit test 9.1.3 Inhalation Toxicity Not performed. This is acceptable since the particle size of the notified chemical is greater than 560 m.
These MSDS were provided by the applicant as part of the notification statement. They are reproduced here as a matter of public record. The accuracy of this information remains the responsibility of the applicant. REQUIREMENTS FOR SECONDARY NOTIFICATION Under the Act, secondary notification of the notified chemical shall be required if any of the circumstances stipulated under subsection 64(2) of the Act arise. No other specific conditions are prescribed. REFERENCES N.I. Sax, R.J. Lewis., Dangerous Properties of Industrial Materials, Published by Van Nostrand, Reinhold, New York, USA (1984). Hartmann, P.H.R. 1994, Acute Oral Toxicity Study with CG 33-1136/TKA 40080, Project no., 944067, Ciba-Geigy Ltd., Stein. Switzerland. Organisation for Economic Co-operation and Development 1995-1996, OECD Guidelines for the Testing of Chemicals on CD-Rom, OECD, Paris. Hartmann, P.H.R. 1994, Acute Dermal Toxicity Study with CG 33-1136/TKA 40080, Project no., 944067, Ciba-Geigy Ltd., Stein. Switzerland. Marty, J.H., 1994, Acute Dermal Irritation/Corrosion Study in Rabbits with CG 33- 1136/TKA 40080, Project no., 944064, Ciba-Geigy Ltd, Stein, Switzerland. Marty, J.H., 1994, Acute Eye Irritation/Corrosion Study in Rabbits with CG 33- 1136/TKA 40080, Project no., 944065, Ciba-Geigy Ltd, Stein, Switzerland. Draize, J.H. 1959, 'Appraisal of the Safety of Chemicals in Drugs and Cosmetics', Association of Food and Drug Officials of the US, vol. 49, pp. Marty, J.H., 1995, Skin Sensitisation Test in the Guinea pig with CG 33-1136/TKA 40080, Project no., 944066, Ciba-Geigy Ltd, Stein, Switzerland. Bachmann P.M., 1995, 3-Month Oral Toxicity Study in Rats (Gavage) with CG 33- 1136/TKA 40080, Project no., 944063, Ciba-Geigy Ltd, Stein, Switzerland.