zilongwang/ReadingBank huggingface dataset:
RASG-PA ESC/30 — WP/** **/**/18 Thirtieth Regional Aviation Safety Group — Pan America Executive Steering Committee Meeting (RASG-PA ESC/30) Washington, D.C., United States, 22 to 23 2018 Agenda Item *: TITLE OF WORKING PAPER (Presented by ***) EXECUTIVE SUMMARY Insert brief summary of the working paper. Action: Insert action required. Strategic Objectives: Safety References: *** 1. Introduction 1.1 Ff — — — — — — — — — — — or — END —
RASG-PA ESC/29 — IP/** **/**/18 Thirtieth Regional Aviation Safety Group — Pan America Executive Steering Committee Meeting (RASG-PA ESC/30) Washington, D.C., United States, 22 to 23 March 2018 Agenda Item *: TITLE OF INFORMATION PAPER (Presented by ***) EXECUTIVE SUMMARY Insert brief summary of the information paper. Strategic Objectives: Safety References: *** 1. Introduction 1.1 Ff — — — — — — — — — — — or — END —
NAM/CAR/CATC/WG/4 — WP/** **/**/18 Fourth NAM/CAR Civil Aviation Training Centres Working Group Meeting (NAM/CAR/CATC/WG/4) ICAO NACC Regional Office, Mexico City, Mexico, 6 to 8 June 2018 Agenda Item *: TITLE OF WORKING PAPER (Presented by ***) EXECUTIVE SUMMARY Insert brief summary of the working paper. Action: Insert action required. Strategic Objectives: Safety Air Navigation Capacity and Efficiency Security & Facilitation Economic Development of Air Transport Environmental Protection References: *** 1. Introduction 1.1 Ff — — — — — — — — — — — or — END —
Home telephone number: Mobile telephone number: Fax number: E-mail: Languages Mother tongue: Other languages Read Write Speak Very well Well Fairly Well Very well Well Fairly well Very well Well Fairly well experience: Total number of years: Current and previous areas of security activity and responsibility: • Cargo and mail: Yes No • Catering: Yes No • Hold baggage: Yes No • Passenger and cabin baggage: Yes No • Pax/bag reconciliation: Yes No • Access control: Yes No • Quality control: Yes No • Contingency planning: Yes No Scope of activity: National International Do you manage staff (e.g. inspectors)? Yes No 6. Technical and/or specialized training record: Name and of training institute Subject(s) studied Period Diploma/Certificate acquired From To
NA/722 FULL PUBLIC REPORT CYASORBUV – 3638 1. APPLICANT Cytec Australia Holdings Pty Ltd of 7-11 Railway Street BAULKHAM HILLS NSW and Eastman Chemical Company Ltd of 15 Talavera Road NORTH RYDE NSW have jointly submitted a standard notification statement in support of their application for an assessment certificate for CYASORBUV – 3638. 2. IDENTITY OF THE CHEMICAL Chemical Name: 4H-3, 1-benzoxazin-4-one, 2,2’-(1,4-phenylene)bis- Other Names: 4H-3,1-benzoxazin-4-one, 2,2’- (1,4-phenylenebis- 2,2’-(1,4-phenylene)bis(4H-3,1-benzoxazin-4-one) 2,2’-(p-phenylene)di-3,1-benzoxazin-4-one 2,2’-p-phenylenebis-4H-3,1-benzoxazin-4-one Chemical Abstracts Service (CAS) Registry No.: 18600-59-4 Marketing Name: CYASORBUV – 3638 CYASORBUV – 3638 Stabiliser Molecular Formula: C22H12N2O4 Structural Formula: Molecular Weight: 368
PART 1 – GENERAL PROVISIONS Section 1.5 Visiting Closures and Public Use Limits the authority of 36 CFR 1.5(a)(1): The following visiting are established for National Capital Parks East Visitor Facilities: 1. Skating Pavilion – May 1 – August 31 9:00 a.m. – 5:00 p.m. – September 1 – 30 2. 9:00 a.m. – 4:30 p.m. – October 16 through April 16 8:30 a.m. – 5:30 p.m. – April 17 through October 15 3. Frederick Douglass National Historic Site – October 16 through April 14 daily – April 15 through October 15 4. Ranger Station 5. daily 6.
EVALUATION OF TOXICOLOGICAL DATA Tests were performed according to OECD test guidelines (OECD 1995-1996) at facilities complying with OECD Principles of Good Laboratory Practice. Toxicity Summary of the acute toxicity of LumiNova Test Species Outcome Reference acute oral toxicity rat > 2 000 mg/kg (McRae, 1995) acute dermal toxicity skin irritation rat rabbit > 2 000 mg/kg non irritant (McRae, 1995) (Parcell, 1995) eye irritation skin sensitisation rabbit guinea pig slight irritant non sensitising (Parcell, 1995) (Allan, 1995) Oral Toxicity (McRae, 1995) Species/strain: rat/ Sprague Dawley (CD) Number/sex of animals: 5/sex per group Observation period: 15 days Method of administration: a single dose of 2 000 mg/kg (20% w/v solution in corn oil) administered by gavage Test method: OECD TG 401 – Test Clinical observations: pilo-erection was observed in all animals through to Day 2 Mortality: none Morphological findings: none LD50: > 2 000 mg/kg Result: the notified chemical was of very low oral toxicity in rats
Dermal Toxicity (McRae, 1995) Species/strain: rat/ Sprague Dawley Number/sex of animals: 5/sex Observation period: 15 days Method of administration: a single dose of 2 000 mg/kg (166.67% w/v in corn oil) applied to an intact skin site and covered with semi- occlusive dressing; after 24 hours the dressing and residual test material were removed Clinical observations: bodyweight fluctuations in the occasional animal Test method: OECD TG 402 Mortality: none Morphological findings: none LD50: > 2 000 mg/kg Result: the notified chemical was of very low dermal toxicity in rats Inhalation Toxicity An acute inhalation toxicity test has not been conducted for the notified chemical and claims were made and accepted for variation of schedule requirements for this toxicological end point. To support their claim the notifier states that the median particle size of the notified chemical is 40 m in diameter, with less than 10% with a diameter of 10 m. This coupled with the high specific gravity and negligible vapour pressure of the substance, limits exposure via the inhalation The notifier also states that acute dermal and oral studies indicate the notified chemical is unlikely to be harmful. Skin Irritation (Parcell, 1995) Species/strain: rabbit/New Zealand White Number/sex of animals: 3 females Observation period: 4 days Method of administration: 0.5 g of the test substance was applied to intact skin site; the site was covered with semi occlusive dressing; after 4 hours the dressing and residual test material were removed Test method: OECD TG 404
(Covance Laboratories Inc 1998b) OGA 600 Undiluted (39% OGA 499) Test 2 16 2 0 0 4 15 1 0 0 Naïve 4 5 1 0 0 2 7 1 0 0 No. of test animals with positive response: 2/20 1/20 5% OGA 600 in mineral oil (2% OGA 499) Test 20 0 0 0 0 18 2 0 0 0 Naïve 10 0 0 0 0 10 0 0 0 0 Total No. of test animals with positive response: 0/20 0/20 OGA 600 Diluted to 1% OGA 499 in mineral oil. (Covance Laboratories Inc 50% OGA 600 w/v in mineral oil (0.5% OGA 499) 25% OGA 600 w/v in mineral oil (0.25% OGA 499) Test 6 14 0 0 0 7 13 0 0 0 Non- Sensitising Naïve 1 9 0 0 0 1 9 0 0 0 Total No. of test animals with positive response: 0/20 0/20 1 – One animal was euthanised on Day 29. Necropsy did not reveal treatment related effects.
More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 2 mod. 3 severe Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 2 mild 3 mod. 4 severe Discharge with moistening of lids and adjacent Discharge with moistening of lids and hairs and considerable area around eye 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
micelle formation tendencies, the OLOA 246R will tend to partition from water to solids or organic matter. The notified chemical will not dissociate. Although the chemical contains calcium the complex organic nature of this substance and the tendency to form micelles indicates dissociation is unlikely. Due to the low volatility of the notified chemical, flammability limits in air not be determined. The oil will burn if preheated, and is a Class C2 combustible liquid. 4. PURITY OF THE CHEMICAL Degree of Purity: 54 % in lubricating oil Hazardous Impurities: Chemical name: calcium hydroxide CAS No.: 1305-62-0 Weight percentage: 0.5 % properties: On the NOHSC List of Designated Hazardous Substances (NOHSC, 1999b) Eye, skin, mucous membrane and respiratory system irritant (Sax & Lewis, 1996) exposure standard 5 mg/m3 TWA Non-hazardous Impurities (> 1% by weight): Chemical name: long chain alkylated benzene Weight percentage: 10 % CAS No.: none allocated Additives/Adjuvants: Chemical name: distillates, hydrotreated heavy paraffinic Synonyms: lubricating oil CAS No.: 64742-54-7 Weight percentage: 46 % Toxic properties: On the NOHSC List of Designated Hazardous Substances (NOHSC, 1999b) Classified as a carcinogen, R45(2) unless the DMSO extract under the procedure as defined by IP 346 is shown to be less than 3 %
File No: NA/733 July 1999 NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME FULL PUBLIC REPORT Component in OGA 574 This Assessment has been compiled in accordance with the provisions of the Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) and Regulations. This legislation is an Act of the Commonwealth of Australia. The National Industrial Chemicals Notification and Assessment Scheme (NICNAS) is administered by the National Occupational Health and Safety Commission which also conducts the occupational health & safety assessment. The assessment of environmental hazard is conducted by the Department of the Environment and the assessment of public health is conducted by the Department of Health and Aged Care. For the purposes of subsection 78(1) of the Act, copies of this full public report may be inspected by the public at the Library, National Occupational Health and Safety Commission, 92-94 Parramatta Road, Camperdown NSW 2050, between the following hours: Monday - Wednesday 8.30 am - 5.00 pm Thursday 8.30 am - 8.00 pm Friday 8.30 am - 5.00 pm Copies of this full public report may also be requested, free of charge, by contacting the Administration Coordinator on the fax number For enquiries please contact the Administration Coordinator at: Street Address: 92 -94 Parramatta Rd CAMPERDOWN NSW 2050, AUSTRALIA Postal Address: GPO Box 58, SYDNEY NSW 2001, AUSTRALIA Telephone: (61) (02) 9577 9514 FAX (61) (02) 9577 9465 Director Chemicals Notification and Assessment NA/733
Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 1 slight 2 mod. 3 severe Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 1 slight 2 mild 3 mod. 4 severe Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to haemorrhage, gross destruction 2 severe
(occlusive patch) and applied to the clipped surface of test animals as quickly as possible. Day 7 and Day 13 The induction procedure was repeated. Challenge procedure: Day 27 Chambers containing a challenge dose of 1.25% concentration of test substance were applied to the trunks of test animals and secured for 20 with elastic wrap and tape. Approximately 20 hours after chamber removal for challenge, the test sites were depiliated. Approximately six hours after chamber application, the elastic wrap, tape, and chambers were removed. The test sites were graded for irritation at approximately 24 and 48 hours following chamber application at induction and at approximately 24 and 48 hours following chamber removal at challenge Test method: US EPA Series 81 Comment: Following challenge with 1.25% w/v S10737.01, dermal scores of 0 (no reaction) to (slight patchy erythema) were noted in all test and challenge control animals. Group mean dermal scores were similar between the test and challenge control animals. Result: The analogue chemical was non-sensitising to the skin of guinea pigs. 9.2 A subchronic toxicity test with an analogue compound, xylene sulfonic acid sodium salt, in mice and rats. (Wheeler, 1980) Species/strain: Mouse/B6C3F1; rat/Fischer 344 Number/sex of animals: 5 groups for both species Method of administration: Diet ad libitum; diet levels 0.125%, 0.25%, 0.5%, 1.0% and 2% Dose/Study duration: 91 days Test method: Not stated Clinical observations and findings: Mice Mortality was limited to four mice, three males of the 0.5% level and one female of the lowest (0.125%) level. These deaths were not considered to be treatment related.
Summary of Acute Toxicity Test Species Outcome Reference Acute oral toxicity C16-C18 Esterquat Rat LD50> 2 000 mg/kg (Henkel KGaA, 1994b) Skin irritation Primary Skin Irritation Notified Chemical Rabbit Slight to moderate irritant (Scantox, 1999) Open Epidermal Test C16-C18 Esterquat Non irritating (Henkel KGaA, 1994f) Eye irritation Stepantex VS 90 Rabbit Slight to moderate irritant (Henkel KGaA, 1993) Skin sensitisation: Buehler Method Stepantex VS 90 Guineapig Non sensitising (Henkel KGaA, 1991b) Maximisation Test Stepantex VS 90 Guineapig Inconclusive (Henkel KGaA, 1991c) Repeated Insult Patch Test Dehyquart F75 Human Non sensitising (Pharmaco UK Ltd, 1995) 9.1.1 Oral Toxicity (Henkel KGaA, Test substance: Esterquat C16-C18 Species/strain: Rat/Hsd/Win:WU Number/sex of animals: 5/sex Observation period: 14 days Method of administration: 2 000 mg/kg by gavage, dose volume of 20 mL/kg bw Test method: OECD TG 401; EC Directive 91/325/EEC Clinical observations: No symptoms observed Mortality: Nil Morphological findings: No treatment related findings. One animal had moderate hydrometra in uterine horns
2-8902 Rat LD50 > 1.16 mg/L Sullivan and Rajendran (1997) Skin irritation 2-8075 Rabbit Severe irritant DeVries and Siddiqui Eye irritation 2-8075 Rabbit Moderate irritant DeVries and Siddiqui (1981c) Skin sensitisation 2-8902 2-8075 Guinea pig Guinea pig Weakly sensitising Not sensitising Findlay and Bradshaw (1997); Blaszcak (1999) 9.1.1 Oral Toxicity (DeVries and Siddiqui, 1981d) Species/strain: Rat/Sprague-Dawley Number/sex of animals: 5 males, 5 females Test substance: Dow Corning 2-8075 Observation period: 14 days Method of administration: Gavage Test method: OECD TG 401 Mortality: none Clinical observations: none Morphological findings: none LD50: > 5000 mg/kg Result: The test substance was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (DeVries and Siddiqui, 1981b) Species/strain: Rabbits/New Zealand Number/sex of animals: 5 5 females Test substance: Dow Corning 2-8075 Observation period: 14 days Method of administration: Single 2000 mg/kg dose of neat test substance applied to intact skin and held in place for 24 hours by a porous gauze dressing.
Metabolic activation: 10% rat S9 fraction (Aroclor 1254-induced) in standard cofactors Positive controls: TA98 + S9: 5 g/plate benzo[a]pyrene TA98 – S9: 0.1g/plate 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide TA100 + S9: 5 g/plate benzo[a]pyrene TA100 – S9: 0.01g/plate 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide TA1535 +S9: 2 g/plate 2-aminoanthracene TA1535 – S9: 0.5 g/plate sodium azide TA1537 + S9: 5 g/plate benzo[a]pyrene TA1537 – S9: 80 g/plate 9-aminoacridine TA1538 + S9: 5 g/plate benzo[a]pyrene TA1538 – S9: 2 g/plate 2-nitrofluorene Test method: not stated, similar to OECD TG 471 Comment: no appreciable toxicity was observed at the highest test concentration of 5000 g/plate; precipitation of the test substance was seen at 500 g/plate and higher, but did not interfere with the validity of the test; all concentrations were tested in triplicate and each test was conducted twice under the conditions of the study, the notified chemical caused no substantial increases in revertant colony numbers over control counts at any concentration in either the presence or absence of the rat liver microsomal enzymes all positive and negative controls responded appropriately Result: the notified chemical was non-mutagenic under the conditions of the assay 9.3.2 HPRT forward mutation assay in V79 Chinese hamster cells in vitro (van de Waart, 1991) Cells: V79 Chinese hamster Metabolic activation system: 10% rat liver S9 fraction (Aroclor 1254-induced) in standard cofactors Positive controls: with S9: 8 mM dimethylnitrosamine in HBSS without S9: 6 mM ethylmethanesulfonate in DMSO
9.1.1 Oral Toxicity (Shepard, 1999c) Species/strain: rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: gavage; single dose of 2000 mg/kg of test substance as a 10 % (w/v) suspension in 0.5% carboxymethylcellulose vehicle Test method: OECD TG 401 Mortality: no deaths were recorded during the study period Clinical observations: these were limited to discoloured (light brown) faeces from all animals the day following dosing Morphological findings: no treatment-related changes were observed at necropsy Comment: body weight gain was not adversely affected over the observation period LD50: > 2000 mg/kg Result: the notified chemical was of very low acute oral toxicity in rats 9.1.2 Dermal Toxicity (Jessup, 1999) Species/strain: rat/Sprague Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: single dose of 2000 mg/kg test substance, moistened in was administered under occlusive conditions on the dorsal skin for 24 hours Test method: OECD TG 402 Mortality: no deaths were recorded during the study period Clinical observations: reduced amounts of faeces during days 4 - 7; minor porphyrin discharge during days 4 - 13; weight loss during the first week of the study; each for a single male
NACPM Regulatory Assessment Tool A tool for evaluating proposed legislation or regulations or existing statutes or regulations based on the “Principles for Model U.S. Midwifery Legislation and Regulation” adopted by US MERA October 2015 Name of NACPM state chapter or other state association (if applicable): Name of person(s) completing the questionnaire: Position in the chapter or association: Date completed: US MERA Endorsed Principles How and where is this addressed in proposed or existing language (include citation) If not present, how important is it to your chapter/association that this principle is incorporated? (1 least important 5 most important) If not present, how feasible is it that you affect a change? What will it take to affect a change? Legislative or regulatory agency action? Technical expertise to develop language? Cultivating support from other stakeholders? Engaging lobbyist? Fundraising? Midwifery Regulatory Authority There is a midwifery- specific regulatory authority with adequate statutory powers to effectively regulate midwives and support autonomous midwifery practice. If the midwifery-specific regulatory authority is administratively connected to another or broader authority (e.g. board of health professionals or nursing) the authority must retain final authority over midwifery regulation. The governance structures of the midwifery regulatory authority are set out by the legislation and include, but are not limited to, and responsibilities of board members, powers of the board, and process of appointment of board members and the chairperson.
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area well-defined by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Name CAS Number % Weight notified chemical 178198-11-3 52.7 known coloured by-products – 28.5 unknown coloured by-products – 4.4 unknown uncoloured by-products - 0.1 sodium chloride 7647-14-5 0.2 sodium phosphate 3.8 sodium sulfate 7757-82-6 0.4 sodium fluoride 7681-49-4 0.7 water 7732-18-5 10.3 Additives/Adjuvants: none in the notified substance. Additives and adjuvants are included only in the commercial version of the dyestuff, not in the notified chemical itself. Composition of Cibacron Yellow LS-4G (the product containing the notified chemical): Name CAS Number % Weight Reactive Yellow TZ 4165 178198-11-3 73 sodium tripolyphosphate 7758-29-4 3 sodium sulfate 7757-82-6 15 anti-dust preparation 8012-95-1 1 water 7732-18-5 8 USE, VOLUME AND FORMULATION The dyestuff is an azo dye used for colouring cellulose textiles by the exhaust dyeing method. The dye has a fixation performance of 75%. The notified chemical will not be manufactured in Australia. It will be imported into Australia in a granular form as a component of the product Cibacron Yellow LS-4G at a concentration of 70-75%. It will be imported in polythene lined fibre kegs of 25 kg capacity. Import volumes for the notified chemical are less than 1 tonne per year for the first five years. The notifier anticipates that the dyestuff will be sold to approximately six dyehouses in city and country locations. Some minimal re-packing will for the purpose of supplying samples or material for mill trials. Repacking will be carried out at the notifier’s warehouse. OCCUPATIONAL EXPOSURE The vapour pressure of the notified chemical is low, so exposure to airborne vapours is not anticipated. Respiratory exposure to the notified chemical powder could occur as 45% is in
Oral (drinking water) 14 days Rat- Fischer 344 > 4% dose- decreased body weight (severe dehydration); 2% dose (females)- increased kidney weight Hejtmancik et al., 1985a@ Oral (drinking water) 14 days B6C3F1 8% dose- decreased body weight, dehydration, histologic changes in liver; > 4% dose- decreased thymus weight; NOEL = 9 000-10 000 mg/kg/day Hejtmancik et al., Oral (diet) 28 days Rat > 80 mg/kg/day- mortality, decreased growth rate, histopathology Smyth et al., 1951@ Oral (feed) < 168 days Rat Kidney and histopathology Kindsvatter, 1940@ Oral (gavage) < 168 days Guinea pig Kidney and histopathology Kindsvatter, 1940@ Dermal 14 days Rat- Fischer 344 2 250 mg/kg/d- decreased body weight; > 563 mg/kg/d- skin irritation Hejtmancik et al., Melnick et al., 1988@ Dermal 14 days B6C3F1 All skin irritation (males); > 427 mg/kg/d- skin irritation (females); NOAEL = 281 mg/kg/day(rat), 1 686 mg/kg/day (mouse) Hejtmancik et al., 1985d@; Melnick et al., 1988@ Dermal 91 days Rat- Fischer 344 2 000 mg/kg/d- decreased body weight, blood and urinary effects, pituitary gland hypertrophy; > 250 mg/kg/d- skin irritation (males); > 500 mg/kg/d- increased kidney weight > 1 000 mg/kg/d- increased kidney weight and pathology (females); > 500 mg/kg/d- skin irritation (females) Hejtmancik et al., 1987e@; NTP (1994)@ Dermal 91 days B6C3F1 4 000 mg/kg/d- skin irritation, increased liver and kidney weight*; increased spleen weight (females); All decreased body weight* (males) Hejtmancik et al., 1987f@; NTP (1994)@ Dermal 91 days Mouse- C3H/HeJ Skin irritation DePass et al., 1995@ organ
Comment: There were no consistent, significant clinical, pathological and histopathological findings. Result: A no-observed-adverse-effect-level (NOAEL) of 1000 mg/kg/day for the notified chemical was established. 9.3 Genotoxicity 9.3.1 Reverse Mutation Assay (Wollny, 1997) Strains: Salmonella typhimurium TA 1535, TA1537, TA98, TA 100; Escherischia coli WP2 uvrA Concentration range: 33.3, 100, 333.3, 1000, 2500 and 5000 g/plate Metabolic activation: Aroclor 1254-induced rat liver homogenate, S9 fraction Test method: OECD TG 471, 472 Comment: Plates incubated with the notified chemical showed normal background growth up to 5000g/plate with and without rat liver S9 homogenate. No effects evidenced by reductions in the number of revertants occurred in test groups with and without S9 metabolic activation. No significant or reproducible increase in revertant colonies were observed for any of the colony strains in the presence or absence of metabolic activation for any dose level of the notified chemical. However, a slight increase in the number of revertants was observed in the E. coli strain at 2500 g/plate in the duplicate experiment. This effect could not be repeated in an additional experiment. Reference mutagens used as positive controls showed expected increases in revertant colonies. Result: The notified chemical was not mutagenic at doses up to 5000g/plate in bacteria in the presence or absence of metabolic activation induced by rat liver S9 homogenate. 9.3.2 In vitro Chromosome Aberration Assay in Chinese Hamster Cells (Czich, 1997) Cells: Chinese Hamster V79
animal; 100 % petrolatum was applied to the shaved right flank patches were secured to the torso with bandages for 24 hours and dermal reactions were scored at 24 and 48 hours (Days 22 and 23) after patch removal Test method: OECD TG 406; Magnusson and Kligman maximisation test Comment: approximately 15 min following the intradermal injections, all animals in the treated group had blue skin, eyes, and mucous membranes, as well as blue urine for approximately 3 hours post-injection; after the challenge dose, no dermal reactions were noted for the test animals; control animals responded appropriately Result: the notified chemical was non-sensitising to the skin of guinea pigs 9.2 Repeated Dose Toxicity (Gearhart & Faber, 1998) Species/strain: rat/Sprague-Dawley Number/sex of animals: 5/sex/group Test Substance: HAEL# 97-0042 Method of administration: gavage duration: 1000, 300, 100 and 0 mg/kg/day for 29 days; vehicle corn oil Test method: OECD TG 407 Mortality: all animals survived to the termination of the study Clinical observations: Blue discolouration of the was observed for all treated animals, with colour intensity being minor for the 1000 mg/kg/day groups, and minimal for the 300 and 100 mg/kg/day groups, beginning on Day 0 and continuing for the duration of the study. All treated animals had blue discolouration of the faeces from Day 1 through study termination except for one or two days for the 300 and 100 mg/kg/day groups. Systemic blue discolouration including the skin, eyes, mouth, and/or mucous membranes due to absorption of the test substance was observed for all treated groups following administration of the test substance. No toxicologically significant alterations were observed in the functional observational battery. On Day 14, 300 mg/kg/day males had a significantly higher incidence of
In addition, the omnibus also had specific report language regarding the Farm Service Agency, which I have put below: The agreement provides $1,200,180,000 for the Farm Service Agency. The agreement includes sufficient funding to maintain staffing levels and does not support the significant funding and staffing shifts proposed in the budget request. The agreement does not permit the closure of 250 Farm Service Agency (FSA) county offices or the elimination of 815 non-federal staff years, as proposed in the budget. The agreement reiterates dissatisfaction with the agency's budget submission. The budget request did not provide a rationale for the proposed office closures and staffing changes, did not clearly describe the effect of those proposed actions, and did not include a timeline for the implementation that demonstrates how savings could be achieved. Therefore, the agreement includes a temporary moratorium on closing offices and relocating employees until a comprehensive assessment of workload, based on new farm bill requirements, can be conducted by the agency. FSA is directed to initiate a workload analysis to assess the impact of new farm bill programs on current and future activities in county offices nationwide and complete this analysis by August I, 2015. In addition, the agreement directs the agency to enter into a contract with an independent third party, the National Academy of Public Administration, and includes $900,000 to conduct this independent review of the workload analysis and determine a clear path forward to ensure the agency continues to provide the highest level of customer service. The independent review shall begin within 30 days after completion of the workload analysis by FSA and the review shall be submitted to the Committees no later than one year after FSA has contracted with the third-party entity. The language also highlights the fault by the USDA in implementing a hiring freeze of FSA personnel to fund the further development of MIDAS, which Congress did not approve and which has not produced a working system. The legislation directs the USDA to deliver a finished project, and requires monthly briefings for the committee regarding all IT projects and activities related to farm program delivery.
In [#]: import mne In [#]: import eelbrain In [#]: mne.gui.kit2fiff() Load your marker measurements: Navigate to your assignment data directory. The necessary files are in /data/raw. In Source Marker 1 section, load the pre-test marker .sqd file in File field. In Source Marker 2 section, load the post-test marker .sqd file in File field. Click the central grey window and the markers should appear. You might need to click on ‘Front’ or change the scale to see better. Remember, if there are black portions in the GUI, try the troubleshooting tips mentioned in part A. 3. Load your subject data and digitization in the Sources section: (Note:“Subject” stands for your subject’s ID, “experiment” stands for your study’s experiment name. Your files will be named according to this system; the commands below are just an example) In Data field, load subject_experiment.sqd, the experiment file. In Dig Head Shape field, load subject_experiment.hsp, the head shape file. In in Dig Points field, load subject_experiment.elp, the electrode placement file. 4. Under the dark grey box, click Front so that the head shape appears. Click Right and Left to see that the head moves in the correct direction. What do you notice about this data? 5. Search for your trials in the Events section and save the file. The triggers for this data are 163 (low frequency tones) and 164 (high frequency tones). Enter your two triggers, separated by a comma, and click “Find Events”. Save your transformed .sqd file as a .fif file with a different name, and make sure to use this file in the following steps. Coregistration – adapted from Phoebe Gaston’s Eelbrain Guide Reference Phoebe’s guide if you want to explore source localization in greater detail. Now you will coregister the MEG data with the subject’s structural MRI data to use for source localization later. In the future, if you do not have MRI data for your subject, you can use the average brain. For this assignment, the subject’s MRI data is available to you, in the /mri/ directory. 7. Open the coregistration GUI in ipython: In [#]: mne.gui.coregistration()
Clinical chemistry/ Haematology minor changes in some parameters (haemoglobin, mean corpuscular haemoglobin concentration, neutrophil count) at high dose levels, but all either fell within historical control ranges or were not considered of toxicological importance Biochemistry: mean triglyceride values elevated at high dose levels, statistically significant in females, no associated enzyme changes; minor and inconsistent changes in albumin; other biochemical changes were minor and largely within historical control ranges Organ weights minor changes in liver, kidney and spleen weights noted among high dose level females; considered by authors not to be of toxicological importance Histopathology: no treatment related abnormalities (macroscopic or microscopic) were observed; Comment: based on the clinical observations at the two higher doses, the NOEL is 15 mg/kg/day Result: the clinical and biochemical symptoms do not constitute major functional disturbance and so the test substance will not require corresponding health effects labelling Genotoxicity Salmonella typhimurium/Escherichia coli Reverse Mutation Assay (Kitching, 1998) Strains: Salmonella typhimurium TA1535, TA1537, TA98 and TA100 Escherichia coli CM891 Concentration 1.5 to 5000 g/plate Test method: According to OECD TG 471/472 Comment: no evidence of mutagenic activity observed at any dose level of test material in either mutation assay, in the absence or presence of metabolic activation provided by rat liver S9 fraction
benzaldehyde IPD m-XDA DETA TETA rat LD50 1 300 mg/kg no data LD50 660 mg/kg LD50 1 080 mg/kg LD50 2 500 mg/kg - ACGIH ACGIH Acute dermal toxicity benzaldehyde IPD m-XDA DETA TETA rabbit LD50 >1 250 mg/kg no data LD50 2 000 mg/kg LD50 1 090 mg/kg LD50 805 mg/kg BIBRA - ACGIH ACGIH, RTECS RTECS Acute inhalation toxicity benzaldehyde IPD m-XDA DETA TETA rat LC50 >7 000 mg/m3 no data LC50 3750 mg/m3 (I hour) equivalent to 1900 mg/m3 (4 hour) no deaths following 300 ppm exposure for 8 hours LC50 805 mg/m3 BIBRA - ACGIH ACGIH RTECS Skin irritation benzaldehyde IPD m-XDA DETA TETA rabbit human guinea pig rabbit moderate irritant non irritant (4% in petrolatum, 48 hour occlusive application no data corrosive moderate to severe irritation severe irritation BIBRA ACGIH RTECS Eye irritation benzaldehyde IPD m-XDA DETA TETA rabbit - rat rabbit human rabbit irritant at 0.2% no data exposure to aerosol produced ocular irritation and lacrimation severe irritant severe corneal injury after application of a 15 % solution; minor corneal injury with 5% solution moderate to severe irritant - ACGIH RTECS ACGIH Skin sensitisation
5 PR 1418 Rev 1.0 Dec-03 6 PR 1418 Rev 1.0 Dec-03 7 PR 1418 Rev 1.0 Dec-03 Part III section 4.1.2 of Part III gives the template for a NAD report (also copied below). 4.1.2 Non-accidental Death Reports Where non-accidental death occurs to a person who is currently employed by, or on contract to, the Company, records of medical pre-employment checks, periodic medical checks, information about the work and work conditions preceding the death should, if available be subject to investigation. This also applies to non-accidental deaths outside normal working hours. The objective of this investigation is to ascertain whether the cause of the fatality relates to systems and conditions which are managed by the Company and may provide the grounds for corrective action. If this is the case, such a fatality should be reported immediately and be included in the Company statistics. The contents of death reports should be based on the following template where relevant. This is the information required by PDO and SIEP. 1 2. EVENT DETAILS 2.1 Time, Date, Place of Death: 2.2 Details of the Deceased : Name; Company Number; Date Of Birth; Job; 2.3 Nature of injuries/cause of death: 2.4 Sequence of Events leading to the discovery of the deceased: Sequence of Events following the discovery of the deceased: 2.6 Post Incident response: 2.6.1 Where death occurred within the Company fence, were the Company Medical Emergency Response (including First Aid, Medical Treatment and Medevac ) procedures suitable and complied with? 3. INVESTIGATION DETAILS 3.1 Investigation Team (including medical officer or occupation health adviser). 3.2 Persons Interviewed : 3.3 Examination of relevant site / living conditions (vehicles, equipment, accommodation, etc.)
Attachment 1 The Draize Scale (Draize, 1959) for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area well-defined by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale (Draize et al., 1944) for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Addendum to 2018-2019 7th Grade Social Studies Syllabus Please keep the following information for your records. Course Content Overview The 7th grade curriculum covers many different cultures and time periods of world history. Weekly updates will be sent via Remind and/or email in regards to pacing and calendar for assignments. We will discuss the following areas: Unit Objectives of TNReady Assignments Approx. Dates Legacy of Rome/Early Christianity Analyze the legacy of Rome and the of early Christianity. 3% “What is a legacy?” PBL Review of early Christian cultural beliefs (6th grade) August 1 -17 China (400 – 1500s) Analyze the geographic, political, economic, social, and religious structures of the civilizations 12% Ming Dynasty Golden Age of China Mongols PBL Oct. 9 – Nov. 8 Japan (400 – 1500s) Analyze the geographic, political, economic, social, and religious structures of the civilizations 7% Japanese Feudalism PBL Nov. 9 - 19 Southwest Asia (400 – 1500s) Analyze the geographic, political, economic, social, and religious structures of the civilizations 14% Eclipse PBL Cultural Comparisons August 18 – Sept. 15 Africa (400 – Analyze the geographic, political, economic, social, and religious structures of the civilizations 8% Trans-Saharan Trade PBL Specialization Essay Sept. 18 - 29 Middle Ages in Western Europe (400 – 1500s) Analyze the geographic, political, economic, social, and religious structures of the civilizations 15% • Feudalism PBL •Crusades PBL Dec. 4 - 21 Renaissance & Reformation in Europe Analyze the origins, accomplishments, and geographic diffusion of the Renaissance and the historical developments of the Reformation 22% Renaissance PBL Reformation’s Impact Jan. 4 – Feb. 15 Scientific Revolution & Age of Enlightenment Analyze the historical developments of the Scientific Revolution and its lasting effect on religious, political, & cultural institutions Students analyze political, social, & economic change as a result of the Age of Enlightenment in Europe 7% Impacts of Enlightenment Impacts of Scientific Revolution Feb. 16 - 28 Age of Exploration Compare & contrast the geographic, political, religious, social, & economic structures of the Mesoamerican and Andean civilizations. 16% “European Explorers: Heroes or Villains?” PBL and Debates March 1 – April 7
Undergraduate Courses (General Program) Undergraduate Courses (Clinical Program) Postgraduate Courses Pharmacometrics (2301) Screening of drugs and biostatistics (1310) Career History and Professional Experience Titles Lecturer Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt June 2013- to date Postdoctoral Fellow Department of Anaesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada and TherExcell Pharma Inc., Vancouver, Canada May 2012- Apr 2013 Research Assistant Department of Anaesthesiology, Pharmacology & Therapeutics, University of British Columbia, Canada Sep 2005- Apr 2012 Teaching Assistant Centre for Intercultural Communication, Continuing Studies, University of British Columbia, Canada Sep 2008- Mar 2011 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt Nov 1996- Sep 2005 Community Pharmacist El-Badry pharmacy, Giza, Egypt Aug 1996- Apr 1998 Awards Projects
[insert organisation name and logo] Board Development Plan Area identified for improvement Goal Activities Person responsible Timeline 1. Low number of Board members Have a minimum of 9 of the 10 positions filled at any one time. Advertise for Board members and approach people with right skill-set Chair and CEO. All Board members to do word-of-mouth June 2012 Prepare Prospective Board membership pack CEO June 2012 Interview prospective Board members and provide with membership pack Chair 2012 Ensure prospective Board members attend AGM Chair October 2012 2. Board members have similar backgrounds Increase diversity of Board members In advertising for and approaching prospective Board members, encourage CALD and Aboriginal applicants Chair and CEO. All Board members to do word-of-mouth October 2012 3. No Board members with qualification or experience in human resources or staff management Have at 2 Board members with human resources/staff management experience/skills In advertising for and approaching prospective Board members, seek people with relevant training/experience Chair and CEO. All Board members to do word-of-mouth October 2012 4. Low confidence in understanding the legal obligations of Board Directors High confidence amongst all Board members about the legal obligations of Board members Provide full-day training to all Board members on corporate governance, focusing on legal obligations CEO to organise March 2012 then every year after AGM 5. Meetings are too long, there are too many papers, and never get to finish discussion Limit meetings to 2 hours and have standard agenda and papers. Bring in consultant to observe meeting and provide advice. CEO to organise April 2012 Establish templates and develop new procedure based on consultant’s advice CEO and Secretary June 2012 Review new procedure CEO and Secretary November 2012 6. CEO and relationship could be better High confidence in CEO/Chair relationship from both CEO and Chair Implement face-to-face meetings between CEO and Chair mid-month, in between Board meetings CEO and Chair Monthly
File No: NA/818 September 2002 NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME FULL PUBLIC REPORT Jaguar C-162 This Assessment has been compiled in accordance with the provisions of the Industrial Chemicals (Notification and Assessment) Act 1989 (the Act) and Regulations. This legislation is an Act of the Commonwealth of Australia. The National Industrial Chemicals Notification and Assessment Scheme (NICNAS) is administered by the National Occupational Health and Safety Commission which also conducts the occupational health & safety assessment. The assessment of environmental hazard is conducted by the Department of the Environment and the assessment of public health is conducted by the Department of Health and Aged Care. For the purposes of subsection 78(1) of the Act, copies of this full public report may be inspected by the public at the Library, National Occupational Health and Safety Commission, Plaza level, Alan Woods Building, 25 Constitution Avenue, Canberra ACT 2600 between 9 AM and 5 PM Monday to Friday. Copies of this full public report may also be requested, free of charge, by contacting the Administration Coordinator on the fax number below. For enquiries please contact the Administration Section at: Street Address: 334-336 Illawarra Rd MARRICKVILLE NSW 2204, AUSTRALIA Postal Address: GPO Box 58, SYDNEY NSW 2001, AUSTRALIA Telephone: (61) (02) 8577 8816 FAX (61) (02) 8577 8888 Director Chemicals Notification and Assessment
Method of administration: 2020 mg/kg in corn oil patches. Test method: Not stated. Mortality: Nil Clinical observations: Not stated. Morphological findings: Not stated. LD50: > 2020 mg/kg Result: AG-RHO DR-2000 was of very low dermal toxicity in rabbits. Acute Inhalation Toxicity No study of acute inhalation toxicity was provided by the notifier. Skin Irritation (Toxicol Laboratories Limited, Test substance: Jaguar C-162 Species/strain: Rabbit/New Zealand Number/sex of animals: 6 females Observation period: 7 days Method of administration: A single 4 hour, semi occluded application of 500 mg of test substance, moistened with to intact skin. Test method: OECD TG 404 Cutaneous reactions: Very slight erythema (Grade 1) was observed in one animal one hour after the dressings were removed. No other irritation or other effects of treatment were observed for the duration of the study. 24, 48 & 72 hour group mean score: Erythema/Eschar formulation: 0.0 Oedema: 0.0 Result: Jaguar C-162 was non irritating to rabbit skin.
Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
References Bechhofer, and David McCrone. 2010. « Chosing National Identiy », Sociological Research Online (http://www.socresonline.org.uk/15/3/3.html>10.5153/sro.2191). Bélanger, Éric and Bonnie McGuid. 2008. « Issue Salience, Issue Ownership and Vote Choice », Electoral Studies 27 : 477-91. Bélanger, Éric and Richard Nadeau. 2009a. Le comportement électoral des Québécois. Montreal : Presses de l’Université de Montréal. Bélanger, Éric and Richard Nadeau. 2006. « The Bloc Québécois: A Sour Victory ». In The Canadian Federal Election of 2006, Jon H. Pammett and Christopher Dornan (eds.), Toronto, Dundurn: 122-142. Bélanger, Éric and Richard Nadeau. 2009b. « The Bloc Québécois: A Victory by Default ». In The Canadian Federal Election of 2008, Jon H. Pammett and Christopher Dornan (eds.), Toronto: Dundurn: 136-161. Bélanger, Éric and Andrea M. L. Perrella. 2008. « Facteurs à la souveraineté du Québec chez les jeunes: une comparaison entre francophones, anglophones et allophones », Politiques et Sociétés 27: 13-40. Blais, André and Richard Nadeau. 1992. « To Be or not Be Sovereignist: Quebeckers’ Perennial Dilemma », Canadian Public Policy XVIII: 89-103. André, Pierre Martin and Richard Nadeau. 1995. « Attentes économiques et linguistiques et appui à la souveraineté du Québec », Revue canadienne de science politique 28: 637-657. Blais, André, Elisabeth Gidengil, Richard Nadeau and Neil Nevitte. 2002. Anatomy of a Liberal Victory: Making Sense of the Vote in the 2000 Canadian Election. Peterborough: Broadview Press. based