Toxic properties: Chemical is a severe eye irritant and a skin and respiratory irritant, causing dermatitis. It is mildly by ingestion (Sax and Lewis, 1996). The American Conference of Governmental of Industrial Hygienists (ACGIH) has allocated a Time Weighted Average (TWA) exposure standard of 5 mg/m3 (Sax and Lewis, 1996). Chemical name: Ethylene glycol CAS No.: 107-21-1 Weight percentage: 0.1% max properties: Chemical is harmful if swallowed, when contained in mixtures at >25% (NOHSC, 1999). Chemical name: Phenol, (tetrapropenyl) derivatives CAS No.: 74499-35-7 Weight percentage: 10% max Toxic properties: Chemical is a skin and eye irritant (Biosearch Inc, EPA Doc 86-980000160, 1998; Biosearch Inc. EPA Doc 1998). Toxicity also assumed by analogy with phenol. Chemical name: Phenol, C20-30-alkyl derivatives CAS No.: Not assigned EPA Number: P 96-952, -953, -954, -955, -956, -957 Weight percentage: 4.5% max properties: Toxicity assumed by analogy with phenol. Chemical name: Phenol, (tetrapropenyl) derivatives, manufactured of distillation residues CAS No.: 220794-73-0 Weight percentage: 1% max Toxic properties: Toxicity also assumed by analogy with phenol. Non-hazardous Impurities (> 1% by weight): Chemical name: Phenol, (tetrapropenyl) derivatives, calcium salts Weight percentage: 5% max CAS No.: Not assigned
Chemical name: Phenol, C20-30-akyl derivatives, calcium salts Weight percentage: 5% max CAS No.: Not assigned Chemical name: Sulfurized 2-hydroxybenzoic acid, C20-30-akyl derivatives, tetrapropenyl derivatives and (tetrapropenyl) derivatives, reaction products with distillation residues from manufacture of, derivatives Weight percentage: < 2% CAS No.: Not assigned Additives/Adjuvants: Chemical name: Lubricating oil solvent : petroleum distillates, hydrotreated heavy paraffinic, DMSO content <2.5%. CAS No.: Weight percentage: Up to 30 % Toxic properties: Classification as a carcinogen applies when the chemical is present in mixtures at greater than 0.1 % and the mixture contains > 3% DMSO. Chemical name: Lubricating oil solvent : petroleum distillates, solvent refined heavy paraffinic, DMSO content <2.5%. CAS No.: 64741-88-4 Weight percentage: Up to 30 % Toxic properties: Classification as a carcinogen applies when the chemical is present in mixtures at greater than 0.1 % and the mixture contains > 3% DMSO. 5. USE, VOLUME AND FORMULATION The notified chemical will not be manufactured in Australia. Up to 210 tons will be imported in the first year either as a 70-80% solution in a highly refined lubricating oil solvent (termed a “component”), or at 10-80% as part of an additive mixture (termed a “package”) with other lubricating oil components. Up to three different packages will be imported. It is anticipated that importation will increase by 2-3% in subsequent years. Both the component and the packages will be blended into finished oils in Australia.
Clinical observations: Soft stools were noted in 7 animals within 4 hours of treatment. Dark staining of the urogenital region was observed in all animals on days 1 and 2. No other signs of toxicity were observed. Morphological findings: No treatment-related macroscopic findings were observed. LD50: > 5000 mg/kg Result: The test chemical is of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Glaza, 1993b) Species/strain: Rat / Crl: CDrBR Number/sex of animals: 5 males and 5 females Observation period: 14 days Method of administration: 2000 mg/kg liquid chemical applied undiluted occlusive dressing. Test method: OECD TG 402 (Limit Study) Mortality: None Clinical observations: No signs of local or systemic toxicity were observed. Morphological findings: No treatment-related macroscopic findings were observed. LD50: > 2000 mg/kg Result: The test chemical is of low dermal toxicity in rats. 9.1.3 Inhalation Toxicity Study not conducted for this viscous liquid of low volatility. 9.1.4 Skin Irritation (Glaza, 1993c) Species/strain: Rabbit / Hra: (NZW) SPF Number/sex of animals: 3 and 3 females Observation period: Up to 96
Method of administration: Undiluted liquid chemical applied for four hours under semi-occlusive dressing. Test method: OECD TG 404 Draize scores: Time Animal # treatment (days) 1 2 3 4 5 6 Erythema 0 0 Zero scores were recorded for 5/6 animals at all time points 1 1 2 1 3 0 4 0 Oedema 0 Zero scores were recorded in all animals at all time points. 1 2 3 4 a see Attachment 1 for Draize scales Comment: Mean score for all six animals over the 24, 48 and 72 hour time points : Erythema = 0.1 ; Oedema = 0 Result: The test chemical is very slightly irritating to the skin of rabbits. 9.1.5 Eye Irritation (Glaza, 1993d) Species/strain: Rabbit / Hra: (NZW) SPF Number/sex of animals: 3 males and 6 females Observation period: Up to 96 hours Method of administration: 0.1mL liquid test chemical was dropped into the conjunctival sac of one eye in each animal. The eyes of 3 males and 3 females remained unwashed. The eyes of
Skin Sensitisation in Humans, the Analogue Chemical (Boisits et al, 1993) Study Group 105 individuals, predominantly female, aged 21-60 years Test Substance 100% analogue chemical Induction procedure: Test chemical was applied under occlusive dressing to the infrascapular region of the back for 24 hours, on Mondays, Wednesdays and Fridays for 6 applications. Due to skin reactions, the remaining 2 applications were made under semi-occlusive patches. Treated sites were evaluated before reapplication of test chemical. Challenge procedure: Not conducted Test method: Repeated Insult Patch Test in Humans Challenge outcome: Due to intensity of skin reactions produced during induction, the challenge phase of the study was not conducted. Comment: 19 individuals experienced intense reactions either during the course or on completion of the induction phase of the study. 16 of these were considered to be sensitisation reactions. Subjects with severe reactions needed medical treatment to help relieve symptoms, taking up to 6 weeks in the 3 most severe cases. Result: The test chemical was sensitising to the skin of humans. Skin Sensitisation in Guineapigs, using Finished Oil containing 16% Analogue Chemical (Morris, 1994b) Species/strain: Guineapig / Hartley Number of animals: 10 male and 10 female test animals and 5 male and 5 female control animals. Induction procedure: days, 0, 7 and 14 0.3 mL of 100% finished oil (containing 16% analogue chemical), applied to intact skin, occlusive dressing for 6 hours. Control animals received Spectrum Mineral Oil Light. Challenge procedure: day 28 Test and control animals were treated with 0.3 mL of 100% test chemical (16% analogue chemical), to intact skin of a previously untreated site, under occlusive dressing for 6 hours.