COURSE STRUCTURE FOR P.G. PROGRAMMES CENTRE FOR PHARMACEUTICAL SCIENCS, IST, JNTUH PHARMACEUTICS / PHARMACEUTICAL TECHNOLOGY I Year I Semester New Int. marks Ext. marks L P C 1 Core Course I Applied Biopharmaceutics and Pharmacokinetics 25 75 4 -- 4 2 Core Course II Advanced Physical Pharmaceutics 25 75 4 -- 4 3 Core Course III Advanced Pharmaceutical Technology –I 25 75 4 -- 4 4 Core Elective I Modern Pharmaceutical Analytical Techniques 2. Intellectual Property Rights and Regulatory Affairs 25 75 4 -- 4 5 Optional Elective I Herbal Cosmetic Technology Pharmacoepidemiology, Phamracoeconomics and Pharmacovigilance Separation Techniques Advanced Pharmacognosy - I 25 75 4 -- 4 6 Laboratory I Modern Pharmaceutical Analytical Techniques Lab 25 75 -- 6 3 7 Laboratory II Advanced physical Pharmaceutics Lab 25 75 -- 6 3 8 Seminar I 50 -- -- 4 2 Total 225 525 20 16 28 II Semester Int. marks Ext. marks L P C Core Course IV Advanced Drug Delivery Systems 25 75 4 -- 4 Core Course V Industrial Pharmacy 25 75 4 -- 4 Core Course VI Advanced Pharmaceutical Technology II 25 75 4 -- 4 Core Elective II 1. Biostatistics and Research Methodology 2. Screening Methods and Clinical Research 25 75 4 -- 4 Optional Elective Stability of Drugs and Dosage Forms Nano based Drug Delivery Systems Spectral Analysis Advanced Pharmacognosy - II 25 75 4 -- 4 Laboratory III Advanced Drug Delivery Systems Lab 25 75 -- 6 3 Laboratory IV Advanced Pharmaceutical Technology Lab 25 75 -- 6 3 Seminar II 50 -- 4 2 Total 225 525 20 16 28 II Year I Semester Int. marks Ext. marks L P C Comprehensive Viva 0 100 -- -- 4 Seminar-I on Project Work 50 -- -- 24 12 Total 50 100 -- 24 16 II Semester Int. marks Ext.marks L P C 1 Project Work Review II and Project Evaluation (VivaVocxe) 50 150 -- 32 16 Total 50 150 -- 32 16
OPTIONAL ELECTIVE –III SEPARATION TECHNIQUES Objectives: The course is designed to import knowledge in the field of various separation techniques in the context of their applications both at laboratory and industry level. The techniques such as GC, HPLC, Electrophoresis etc. Methods allow qualitative and quantitative estimations and thus demand for the development and validation of methods. UNIT: I Column Chromatography and Short column chromatography: Column packing, sample loading, column development, detection. chromatography and Vacuum liquid chromatography: Objectives, optimization studies, selecting column and stationary phases, selecting suitable mobile phases, automated flash chromatography, and reverse phase flash chromatography. UNIT-II Sample Preparation - Analysis of drugs from formulations and biological samples including, selection of biological sample, extraction of drugs by various methods such as Liquid Liquid Extraction (LLE), Solid Phase Extraction (SPE) and Membrane filtration. UNIT: III HPLC: Principles, basic parameters Retention factor, Capacity factor, Selectivity factor, plate number, plate height, resolution, peak shapes, band broadening, van Deemter equation and curve. Column selection and optimization, column problems, solvents, trouble shooting, sample preparation. Method Development and validation: Introduction, Forced Degradation Studies Approach to Forced Degradation Studies. Stability Indicating HPLC Method Development - Method Scope, Preliminary Requirements, Method Development Approach, Method Optimization and validation. UNIT-IV Gas Chromatography: Principles, injector, head space sampling, columns for GC, detectors, quantification, derivatization techniques. Hyphenated techniques: Introduction to GC-MS and LC-MS techniques and their applications. UNIT-V Electrophoresis: Capillary electrophoresis: principle (zeta potential), instrumentation, different modes of CE, advantages and disadvantages, pharmaceutical applications. Counter current chromatography: principles, droplet counter current chromatography, centrifugal partition chromatography, choice of solvents for SP and MP. Experimental