zilongwang/ReadingBank huggingface dataset:
to give an environment release of 46 ppb. This is more than orders of magnitude below the EC50 for daphnia. It is likely that most of the polymer will be in the solid waste, at the tannery or the sewage treatment works, with little in the waste water. The actual release is expected to be significantly less than 46 ppb as a result of incorporation in the solid wastes. Due to the molecular weight of the polymer it is not expected to bioaccumulate and will biologically degrade, thus it will not build up in the environment. The Environmental hazard of Aqualen Top D2012 and the polymer is expected to be low due and with the small quantities to be imported it will not present an environment hazard. ASSESSMENT OF PUBLIC AND OCCUPATIONAL HEALTH AND SAFETY EFFECTS There is no information on the effect of Aqualen Top D2012 on human exposure. Based on the results of animals studies on a similar polymer (Melio Promul 68), the notified polymer may have low acute oral toxicity. Aqualen Top has low vapour pressure is not explosive is not flammable and is non-reactive under normal use conditions. The maximum exposure of each worker to the notified polymer is one hour a day during preparation of the finish coat and quality control checks. The application of the finish coat is carried out in an enclosed booth or under positive ventilation. Under normal use conditions, given the physico-chemical profile of the notified chemical together with the engineering controls, this exposure is unlikely to result in any adverse health effects. The public is unlikely to be exposed to the notified polymer during importation and transport to tanneries. However, the public may have contact with the polymer, when it is used as a component in leather surface coatings.
Reference 25 in Hobbs S. Industry Category Document: UK Dye Production and Use in the Textile Industry, UK Department of the Environment (CR36/38), July 1988. Yen C-P., Perenich T. A. and Baughman G. L. Environmental Toxicology and Chemistry, 1991, 10, 1009-1017. Weber E. J. Environmental Toxicology and Chemistry, 10, 609- 618, 1991,. RCC Project 298495. Acute Oral Toxicity with FAT 40'408/A in Rats. Research and Consulting Company AG, 1991. RCC Project 298506. Acute Dermal Toxicity with FAT 40'408/A in Rats. Research and Consulting Company AG, 1991. RCC Project 298517. Primary Skin Irritation Study with FAT 40'408/A in Rabbits (4-Hour Semi-Occlusive Application). Research and Consulting Company AG, 1991. RCC Project 298528. Primary Eye Irritation Study with FAT 40'408/A in Rabbits. Research and Consulting Company AG, 1991. RCC Project 298530. Contact Hypersensitivity to FAT 40'408/A in Albino Guinea Pigs. Maximization test. Research and Consulting Company AG, 1991. OECD Guidelines for Testing of chemicals - Acute Oral Toxicity No: 401, 1981. OECD Guidelines for Testing of chemicals - Acute Dermal Toxicity No: 402, 1981. OECD Guidelines for Testing of Chemicals - Acute Dermal Irritation/Corrosion No: 404, 1981. OECD Guidelines for Testing of chemicals - Acute Eye Irritation/Corrosion No:405, 1987. OECD Guidelines for Testing of chemicals - Skin Sensitisation No:406, 1981.
Yellow staining of the treated skin by the test substance was observed. Very slight erythema was observed in 2/10 animals and slight oedema in one animal at the end of 60 mins. The skin irritation was reversed within 24 hours after exposure in all three animals. No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. The results of this test indicate that PF-310 is not a skin irritant. Eye Irritation (4) The test was conducted in accordance with OECD Guidelines for Testing of Chemicals No 405 One hundred milligrams of PF-310 was instilled into the conjunctival sac of one eye of three New Zealand strain albino rabbits. The other eye served as the control. The eyes of each animal were examined 1, 24, 48 and 72 hours and 7, 14 and 21 days after instillation of the test substance. After the 24 hr observation a solution of 2% fluorescein was instilled into both eyes to quantitatively determine corneal epithelial damage. This procedure was repeated in all the animals on days 4, 8, 15 and 22. At the end of 1 hr congestion, swelling and circumcorneal hyperaemia were observed in the iris of all three rabbits. PF- 310 also caused redness and chemosis of the conjunctivae of the three rabbits. The injection of the iris was reversed within 21 days after instillation in 2/3 rabbits. The three animals showed translucent corneal opacity and neovascularisation, diffuse beefy redness of the conjunctivae and some discharge on day 22. Treatment of the eyes with 2% fluorescein revealed corneal epithelial damage in all three animals. No systemic symptoms were observed in the animals and no mortality occurred. The results of this test indicate that PF-310 is corrosive to the eye. Skin Sensitisation (5) This study was carried out in accordance with the OECD Guidelines for the Testing of Chemicals No 406.
Monomers: . Identity: Synonym: Ethenylbenzene Styrene CAS No.: 100-42-5 Weight percentage: 76.8% . Identity: Synonym: 2-Propenoic acid, butyl ester Butyl acrylate CAS No.: 141-32-2 Weight percentage: 22.9% . Identity: Diethenylbenzene Synonym: CAS No.: Benzene, divinyl 1321-74-0 Weight percentage: 0.3% Maximum content of residual monomers: <0.2% (w/w) PHYSICAL AND CHEMICAL PROPERTIES Styrene acrylate copolymer consists of fine white beads at room temperature and atmospheric pressure. Its physical and chemical properties include: Glass-transition temperature: 56.7-64.8°C Vapour pressure: negligible; the chemical is a cross-linked polymer Water solubility: negligible; the chemical is cross-linked polymer Explosion potential: this material, like most organic materials in powder form, is capable of creating a dust explosion Reactivity: incompatible with strong oxidisers Particle size distribution: range: 63-116 microns The notifier has justified the lack of test results for hydrolysis, partition coefficient and soil adsorption on the grounds that the notified substance is a high molecular weight, linked polymer with negligible vapour pressure and water
OCCUPATIONAL EXPOSURE The notified polymer is shipped in bulk liquid tank containers in approximately 20 tonne parcels or in chemical parcel tankers approximately in 150 to 400 tonne lots. In Australia the notified polymer will be supplied to approximately 25 locations for storage and warehousing prior to distribution for blending motor oils. Distribution of additive packages containing the polymer will be by road and rail. The notified polymer has been used in several European countries for approximately 12 months. Two blenders, two laboratory technicians and a number of storemen and transport personnel will be exposed to the notified polymer, at the Melbourne blending plant. Those handling additive packages containing ADX 221 at major oil blending installations will also be exposed to the notified polymer. If leaks or spills occur exposure to the notified polymer is possible as part of the following activities: . decanting or transfer from bulk iso tanks to storage vessels or blending kettles; and . transfer from blend kettles to bulk road tankers or drums. PUBLIC EXPOSURE There is negligible potential for public exposure to ADX 221 during blending operations, which will be performed in bunded areas. Any spilled material is to be disposed of by incineration or landfill. However, members of the public who undertake own vehicle maintenance may become dermally exposed to the notified polymer when using and/or disposing of oils containing ADX 221, or handling engine components. A moderate level of exposure may be anticipated in persons who perform frequent maintenance tasks.
PURITY OF THE CHEMICAL Degree of purity (of the notified chemical only): 88.95% Maximum content of residual monomers: 11.05% Additives/Adjuvants: The alkenylsuccinimide polymer will be imported into Australia as a solution in diluent oil and as a 25-60% component in lubricant oil additive packages. Products containing the new polymer will include TLA-1609 and other additive packages. It will be used as a dispersant additive in the manufacture of crankcase lubricants by the petroleum and related industries. The dispersants are used to solubilise sludge and inhibit the formation of sludge precursors in lubricants. The crankcase lubricants containing the notified polymer will be used in petrol engines (predominantly passenger car motor vehicles and light commercial vehicles) and diesel engines. Approximately 45% of total diesel
----------------------------------------------------------------- Paint plant operators 10 blend the paint and collect samples for quality control 8 hours/day, 35-45 days/year Maintenance personnel 2 repair and the mixing vessel, transfer lines, pumps, mixers etc 1 hour/day, 5 days/year Laboratory technicians/ chemists 5 trouble shooting 2-4 hours/day, 10 days/year none Storage personnel ----------------------------------------------------------------- The majority of handling procedures will be conducted in closed vessels and local exhaust ventilation will be in place during sampling, laboratory testing and drum filling. The internal transport and storage personnel will handle drummed polymer only and are not expected to be exposed during the normal course of their work. At each paint applicator site a maximum of 18 workers will be involved in paint application.
FULL PUBLIC REPORT NA/191 APPLICANT Lubrizol Australia of 28 River St, Silverwater, NSW 2141 have submitted a standard notification for assessment of Z-17. IDENTITY OF THE CHEMICAL Z-17 is not considered to be hazardous based on the nature of the chemical and the data provided. Therefore the chemical name, CAS number, molecular and structural formulae, exact use, exact molecular weight and exact import volume have been exempted from publication in the Full Public Report and the Summary Report Other name: Z-17 Molecular weight: < 1000 Method of detection and determination: UV/Vis, Infrared and NMR spectroscopy PHYSICAL AND CHEMICAL PROPERTIES Appearance at 20°C and 101.3 kPa: yellow liquid Pour point: -39°C Boiling 176°C Density: 1060 kg/m3 at 22°C Vapour pressure: 2 X 10-4 Pa at 21°C Water Solubility: 2.2 X 10-3 g/L at pH 4.0 2.6 X 10-3 g/L at pH 7.0 2.8 X 10-3 g/L at pH 9.0 Hydrolysis as a function of pH: half-life: pH 4, 55°C, 45 hours pH 4, 65°C, 21 hours pH 7, 35°C, 118 at 50°C the notified chemical degraded 11.7% and 48.7% at pH 4 and pH 7, respectively, after 5 days and 52.6% at pH 9 for 2.5 hours
Teaching/ Learning Principles □ Clearly defines and discusses relevant teaching/learning principles relevant to client □ Identifies and discusses relevant teaching/learning principles relevant to client □ Vague/incomplete identification and discussion of relevant teaching/learning principles relevant to client. □ Does not identify or discuss relevant teaching/learning principles relevant to client. □ Clearly states rationale from readings to support choice of teaching/learning principles □ Includes rationale from readings to support choice of teaching/learning principles □ Vague/incomplete or inaccurate rationale supporting choice of teaching/learning principles □ Does not include rationales which support choice of teaching/learning principles □ Excellent use of references with strong support selection of teaching/learning principles, with appropriate citations. □ Good use of references for support of selection of teaching/learning principles, with appropriate citations. □ Weak use of references with unclearly support selection of teaching/learning principles, with appropriate citations. □ Inappropriate or absent use of reference sources; inappropriate citation. Quality of Writing □ Well organized, easy to follow line of thought. Clear and thorough response. □ Organized, easy to follow line of thought. Clear response. □ Some ideas made clear, but not all. Some parts of response explained better than others. Organization distracts from content □ Poorly organized, affects ability to follow □Writing is careful and precise, shows student’s interest and involvement with the issue. □ Writing shows student’s interest and involvement with the issue. □ Writing occasionally interesting and persuasive, but presentation not consistent throughout □ Response explained so briefly that reader has to at what is meant. Writing is vague, generic, dull, and brief. □ Correct spelling and complete grammatical sentences. □ Consistent spelling and complete grammatical sentences. □ Poor spelling and grammar distracts the reader □ Problems with sentence structure and punctuation with effect on outcome □ Correct APA format. □ Minor errors in APA format. □ Inconsistent APA format. □ Major problems with format of paper and reference page /24 COMMENTS: STUDENT SIGNATURE: ____ DATE: INSTRUCTOR SIGNATURE: ___ DATE:
Draize (5) Scoresii Animal 1 day Time after instillation 2 days 3 days 4 days 7 days CORNEA: opacity area opacity area opacity area opacity area opacity area 1 2 3 2 3 2 3 2 3 1 1 2 2 2 2 2 2 2 2 2 0 0 3* 2 2 2 2 IRIS 1 1 1 1 1 0 2 2 1 1 1 0 3* 2 2 CONJUNCTIVA ra cb dc ra dc ra dc ra cb dc ra dc 1 3 2 3 2 1 1 2 1 0 2 0 0 1 0 0 2 2 1 2 2 1 2 2 0 2 2 0 2 1 0 0 3* 2 2 3 2 0 2 a redness b chemosis c discharge * terminated 2 days instillation due to due to severity of iridal response Skin Sensitisation (7) Result: sensitiser Species/strain: Albino guinea-pigs Number of animals: 20 test, 10 control (Alpk: Dunkin-Hartley) Induction: Injections of 0.05 - 0.1 mL FCA plus corn oil (1:1); 1% (w/v) notified chemical in corn oil; 1% (w/v) notified chemical in FCA plus corn oil (1:1). Topical induction at day 8: 75% (w/v) notified chemical in corn oil Results: Challenge Concentration 24 hrs test control test control 3% 1/20 0/10 1/20 0/10 10% 5/20* 0/10 5/20* 1/10 All positive responses were scattered mild redness * only 2 animals exhibited a positive response at both 24 and 48 so that 8 animals in all were sensitised - a rate of 30% Test Method: directive 84/449/EEC (2) Test B1
Reactivity/Stability: no known chemical reactions take place Particle size distribution: 95% < 500µm 7-8% < 32µm Comments on Physico-Chemical Properties Since the polymer is a high molecular weight species, its partition co-efficient is estimated to be > 6 (because of its compact structure and molar mass over 600), and as it has a large molecular cross-section (>950 pm), it is not expected to cross biological membranes. Dissociation in water is unlikely on the basis of chemical structure. The adsorption/desorption rates were not determined but their relevance is reduced by the polymer’s low water solubility and use pattern. PURITY OF THE CHEMICAL Degree of purity: 96% Toxic impurities: none Non-toxic impurities (> 1% by weight): < 4% Maximum content of residual monomers: < 0.2% Additives/Adjuvants: none INDUSTRIAL USE Hostavin N30 is intended to be used in plastics applications as a UV light stabiliser which also possesses antioxidant properties, especially for use in polyolefins (polyethylene, both low density and high density, and polypropylene). Hostavin N30 is to be used in cases where precautions against the harmful influence of UV radiation during outdoor exposure have to be adopted. Additionally, Hostavin N30 can be used as a stabiliser against thermal degradation during processing. Typical applications are films, fibres, car bumpers, bottle crates, garden furniture, etc The estimated import of Hostavin N30 containing the notified chemical is greater than 1 tonne per annum in the first five years. OCCUPATIONAL EXPOSURE The notified chemical will be imported into Australia in 25 kg polyethylene bags within fibreboard cartons. A number of additives, including Hostavin N30 at levels normally up to 1%, are added to a mixer together with the appropriate powdered polyolefin grade. Additives may be
56635/8/92, Agrobiology & Environmental Science Unit, Environmental Research Department, Solvay Duphar B.V., 's-Graveland, The Netherlands.Jansen, W.A.J. & Thus L.G. 1983, The Acute Toxicity of Ixol B350 to the Bacteria Pseudomonas putida, Project no., 56835/11/93, Agrobiology & Environmental Science Unit, Environmental Research Department, Solvay Duphar B.V., 's-Graveland, The Netherlands. Standards Australia 1994, Australian Standard 1336-1994, Eye protection in the Industrial Environment, Standards Association of Australia, Sydney. Standards Australia/Standards New Zealand 1992, Australian/New Zealand Standard 1337-1992, Eye Protectors for Industrial Applications, Standards Association of Australia/Standards Association of New Zealand, Sydney/Wellington. Standards Australia 1987, Australian Standard 2919-1987, Industrial Clothing, Standards Association of Australia, Sydney. Standards Australia 1978, Australian Standard 2161-1978, Industrial Safety Gloves and Mittens (excluding electrical and medical gloves), Standards Association of Australia, Sydney. Standards Australia/Standards New Zealand 1994, Australian/New Zealand Standard 2210-1994, Occupational Protective Footwear, Standards Association of Australia/Standards Association of New Zealand, Sydney/Wellington. National Occupational Health and Safety Commission 1994, National Code of Practice for the Preparation of Material Safety Data Sheets [NOHSC:2011(1994)], Australian Government Publishing Service, Canberra.
animal slight redness on days 1 and 2; 2 animals exhibited slight chemosis on day 1, 1 animal moderate chemosis on day 1 and mild chemosis on days 2 and 3; 2 animals exhibited slight discharge on day 1, 1 animal mild discharge on day I and slight discharge on days 2 and 3. 9.1.6 Skin Sensitisation (3) Result: non-sensitiser Species/strain.’ Guinea pig/ Dunkin/Hartley Number of animals: 20 test, 10 control Induction.’ Three pairs of injections of 0.1 mL: FCA in water (1:1); 0.25% notified chemical in Alembicol D with and without FCA (1:1). Topical induction: at day 6, 0.2 mL 10% sodium lauryl sulphate in petrolatum followed 1 day later by 0.4 mL neat notified chemical for 48 hours. Results.’ use of 5O% and 100% v/v notified chemical produced reactions in the controls which, while not suggestive of sensitisation, made scoring imprecise. Therefore a second challenge was conducted one week later as follows: Challenge Concentration 24 hrs 48 hrs test control test control 25% 0/20 0/10 0/20 0/10 5O% 0/20 0/10 0/20 0/10 Test Method.’ based on OECD Guidelines for Testing Chemicals (4). Repeated Dose Toxicity Not supplied. This was acceptable as will be minimal potential for repeated occupation exposure under normal use situations. Genotoxicity Salmonella typhimurium Reverse Mutation Assay (6) Result: non-mutagenic Strains.’ Salmonella typhimurium TA 98, TA 100, TA 1S3S, TA 1S37, TA 1S38 and Escherichia coli WP2uvrA Concentration range.’ 33 - 10000 ~ig/ plate with and without rat liver S9 Test Method.’ based on OECD Guidelines for Testing Chemicals (4).
a redness b chemosis c discharge 9.1.5 Skin Sensitisation (8) Result: Coagulant 122 is not a skin sensitiser in guinea-pigs. Species/strain: Hartley Guinea-Pig Number of animals: 17 males (12 test article, 5 control) Induction: 0.5 mL of test article (100%) was applied to the clipped skin under dressing for 24 hours. A 6-hour contact period was used for subsequent induction applications. The animals were treated with the test article 3 times per week for 3 weeks (total of 9 applications). Challenge: The animals were challenged dermally with the solid test substance for 24 hours 2 weeks after the last induction dose. Results: Table 4 Challenge Concentration 24 hrs 48hrs test control test control 100% 0 0 0 0 Coagulant 122 when applied dermally does not appear to be a dermal sensitiser. Test Method: Modified Buehler Method from USEPA Health Effects Testing Guidelines (3). 9.2 Repeated Dose Toxicity: not performed. Considering that the levels of exposure to Coagulant 122 should be minimal due to protective equipment or mechanical ventilation, it is not considered that any exposure will occur that will reflect repeated dose conditions. 9.3 Genotoxicity 9.3.1 Salmonella typhimurium Reverse Mutation Assay (9) Result: Coagulant 122 was not found to be mutagenic. Strains: Salmonella typhimurium (strains TA1535, TA1537, TA98 & TA 100)
Boca Ciega High School Center for Wellness and Medical Professions Gulfport, FL (727) 893-2780 ext. 2124 C O U R S E S Y L L A B U S Course name Nursing Assistant 3 Course number 8417211 Course description This is a year-long course designed to prepare students for employment as nursing assistants in nursing homes, hospitals or other health care facilities. Course standards This course will cover the following Florida Department of Education standards for Career and Technical Education: 34.0 Use verbal and written communications specific to assisting 35.0 Demonstrate legal and ethical responsibilities specific to nurse assisting 36.0 Perform physical comfort and safety functions specific to nurse assisting 37.0 Provide personal patient care 38.0 Perform patient care procedures 39.0 Apply principles of nutrition 40.0 Provide care for geriatric patients 41.0 Apply the principles of infection control specific to nursing assisting 42.0 Provide biological, psychological and social support 43.0 Perform supervised organizational functions, following the patient plan of care 44.0 Assist with restorative (rehabilitative) activities 45.0 Perform skills related to the hospital setting 46.0 Provide care for the adult patient Pre-requisites Health Science Anatomy and Physiology (8417100) Health Science Foundations (8417110) Text Mosby’s Textbook for Nursing Assistants, 9th Edition Sorentino, Sheila A. Teacher Mr. Michael A. Gauthier, RN, MS, PA-C (referred to as “Mr. G”) 727-893-2780 ext. 1407 (classroom) or 2366 (office) Room 06-008 School year 2017-18 The CWMP student is held to a very high standard of performance. We are preparing future professionals. Professionals are held to a higher standard. The faculty is committed to the success of each of our students, however we are not willing to compromise the standards that make this program and its students so great. The following are the guidelines for reaching the above standards and for evaluating the students for this course.
-pH 4: not stable at 50°C, half-life~149 hours at 25°C -pH 9: not stable at 50°C, half-life~180 days at 25°C Adsorption / Desorption: Not determined Dissociation Constant pKa: -SO3- -2.5>pKa>-3.0 (acidic) Naphthol-NH-triazine pKa ~0.8 (basic) Triazine-NH-CH2- pKa<2 (basic) OH in alpha-Naphthol pKa>11 (basic) Flash Point: Not relevant Flammability Limits: Not highly flammable (flame would not spread) Autoignition Temperature: No ignition 400°C Explosive Properties: Not explosive Reactivity / Stability: No thermal effect below 150°C Not an oxidiser Surface Tension: 60.5 mN/m at 1 g/L 67.9 mN/m at 10 g/L Not a surfactant Particle size distribution: <40 µm 1% >63 µm 96% >100 µm 83% >200 µm 31% >315 µm 14% >400 µm 8% >800 µm <1% Comments on physico-chemical properties: The study (OECD TG 112) of the assessment of the pKa's of the functional groups of the notified chemical indicated that the important pKa's are the strongly acidic -SO3- groups which will render the molecule sixfold negatively charged over the whole environmentally relevant pH region. The possible protonation of the weakly basic amino groups and ionisation of the weakly acidic -OH group will only have a very small effect in the unimportant pH regions below 3 and above 11. trial
NA/318 FULL PUBLIC REPORT PRIAZUL 2102 1. APPLICANT Unichema Australia of 164 Ingles Street PORT MELBOURNE VIC 3207 has submitted for a standard notification statement with their application for the assessment certificate of PRIAZUL 2102. 2. IDENTITY OF THE CHEMICAL PRIAZUL 2102 is not considered to be hazardous based on the nature of the chemical and the data provided. Therefore the composition of the chemical, some information of use and exact estimated import have been exempted from publication in the Full Public Report and the Summary Report. Trade name: PRIAZUL 2102 Structural formula: notified chemical is a complex product of a chemical reaction Method of detection and determination: The notified substance can be isolated by high pressure liquid chromatography (HPLC) and identified by ultraviolet/visual (UV/Vis) , infrared (IR) and nuclear magnetic resonance (NMR) spectral analysis. 3. PHYSICAL AND CHEMICAL PROPERTIES Appearance at 20°C and 101.3 kPa: viscous liquid or paste, pale yellow to brown Odour: none or slightly fatty acid odour Boiling Point: > 191°C at 0.01 mm Hg (theoretical - reduced pressure distillation. Test guideline A.2 EC Directive 84/449/EEC). The compounds are generally decomposed before boiling point is reached. Pour Point: 26°C Density: 1065 kg/m3 at 40°C Vapour Pressure: < 6 x 10-12 kPa at 20C (calculated - modified Watson correlation) Surface Tension at 20°C: 28.9 mN/m (“saturated” solution at 20C). OECD harmonised ring method. Test guideline A.5 EC Directive 84/449/EEC
Appendix A Test Parameters Clinical Chemistry Haematology Urinalysis Organs weighed Histology alanine aminotransferase albumin alkaline phosphatase aspartate aminotransferase bilirubin, total calcium chloride creatinine gamma-glutamyl transpeptidase glucose phosphorous, inorganic potassium protein, sodium urea nitrogen uric acid coagulation time haemoglobin (Hb) Heinz bodies mean corpuscular haemoglobin mean corpuscular volume mean corpuscular haemoglobin concentration packed cell volume (PCV) platelet count red cell morphology red cell (RBC) reticulocyte count white cell count white cell differential appearance bilirubin glucose ketones occult pH protein sediment specific gravity urobilinoge n volume adrenals heart kidneys lungs spleen testes adrenals colon femur bone marrow heart jejunum kidneys liver spleen stomach testes thymus
Cultured Human Lymphocytes 15.6-5000 mg/mL (+/- S9) -ve 9 9.4 Overall Assessment of Toxicological Data The studies demonstrated that the notified chemical (ammonium methanethiosulfonate) has low acute oral and dermal toxicity, is a severe eye irritant, is possibly a skin irritant and does not cause dermal sensitisation. A 28-day oral repeat dose study in rats revealed induction of mild anaemia at the highest dose of 1000 mg/kg/day. The compound showed no genotoxic activity in reverse mutation tests in bacteria (Ames test) nor direct clastogenic activity in human lymphocytes at non-toxic doses. On the basis of submitted data, the notified chemical would be classified as hazardous in accordance with Worksafe Australia’s Approved Criteria for Classifying Hazardous Substances with respect to eye irritation. 10. ASSESSMENT OF ENVIRONMENTAL EFFECTS Results of ecotoxicity tests are summarised. While the chemical can be classified as non-toxic to fish and algae, it is slightly toxic to water fleas, with a 21 day EC50 of 31.8 mg/L. Also, the chemical does not appear to inhibit the activity of bacteria in aerobic sludge. This observation was made during the conduct of the ready biodegradation test. All ecotoxicity tests were performed to test methods following the EC Directive 92/69/EEC. Ecotoxicity test results Species Test Concentrations a (mg/L) Result (mg/L) Rainbow Trout 96 h acute 92.3 LC50 > 92.3 NOEC > 92.3 Water Flea (Daphnia magna) 48 h acute 6.08, 12.2, 26, 50.9, 105 EC50 = 67.6 Water Flea (Daphnia magna) 21 d 5.9, 12.0, 24.7, 48.7, 101 EC50 = 36.8 EC50 (reproduction) = 31.8 & 33.3 (Selenastrum capricornutum ) 96 h growth 97.2 NOEC > 97.2 Aerobic Sludge 5 d 10 NOEC > 10
Easily visible translu cent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness rating Chemosis rating Discharge rating Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely injected above normal 1 slight Any swelling above normal 1 slight Any amount different from normal 1 slight More diffuse, deeper crimson red with individual vessels not easily discernible 2 mod. Obvious swelling with partial eversion of lids 2 mild Discharge with moistening of lids and adjacent hairs 2 mod. Diffuse beefy red 3 severe Swelling with lids 3 mod. Disharge with moistening of lids and and considerable area around eye 3 severe Swelling with lids to completely closed 4 severe IRIS Values rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
NA/339 FULL PUBLIC REPORT GELPASTE UREA 1. APPLICANT Bostik (Australia) Pty Ltd of 51-71 High Street, Thomastown 3074 has submitted for a standard notification statement with their application for an assessment certificate for Gelpaste Urea. The notified chemical will be used as a component an industrial sealant. 2. IDENTITY OF THE CHEMICAL Gelpaste Urea is not considered to be hazardous based on the nature of the chemical and the data provided. Therefore the chemical name, CAS number, molecular and structural formulae, composition and manufacturing process have been exempted from publication in the Full Public Report and the Summary Report Other names: Gelpaste Urea Marketing name: Marketed as the end-use product Bostik Seal’n’Flex 2637, containing less than 5% w/w of Gelpaste Urea. 3. PHYSICAL AND CHEMICAL PROPERTIES All physico-chemical properties of the urea were determined according to the relevant section of OECD Test Guidelines. Appearance at 20°C and 101.3 kPa: Dry, off-white paste Melting point: 234-238 ºC Boiling Not determined Density: Relative density 1.097 at 23ºC Vapour pressure: 8 x 10-6 Pa at 25 ºC solubility: 0.05 ± 0.02 mg/L at 20 ºC Hydrolysis: Test not performed due to the low solubility in water. Urea linkages are unlikely to hydrolyse under environmental conditions. Partition coefficient: Log Pow = 2.7, determined by HPLC. (n-octanol/water)
Vessels normal 0 none No swelling 0 none No discharge 0 none Vessels definitely injected above normal 1 slight Any swelling above normal 1 slight Any amount different from normal 1 slight More diffuse, deeper crimson red with individual vessels not easily discernible 2 mod. Obvious swelling with partial eversion of lids 2 mild Discharge with moistening of lids and adjacent hairs 2 mod. Diffuse beefy red 3 severe Swelling with lids 3 mod. Disharge with moistening of lids and and considerable area around eye 3 severe Swelling with lids to completely closed 4 severe IRIS Values rating Normal 0 none above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Nyholm N (1991), "The European System of Standardised Legal Tests for Assessing the Biodegradability of Chemicals", Environmental Toxicology and Chemistry, 10, p1237-1246. Monomer QM-552 PMN. Acute Oral Toxicity study in Male and Female Rats. Data on File Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477 USA Monomer QM-552 PMN. Acute Dermal Toxicity study in Male and Female Rabbits. Data on File Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477 USA Monomer QM-552 PMN. Skin Irritation Study in Rabbits. Data on File Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477 USA Monomer QM-552 PMN. Eye Irritation Study in Rabbits. Data on File Rohm and Haas Company, 727 Norristown Road, Spring House, Pennsylvania, 19477 USA Delayed contact hypersensitivity in the guinea-pig with QM- 552. Data on File Rohm and Haas Company, European Operations, Chesterfield House, Bloomsbury Way, LONDON WC1A 2TP, ENGLAND. Twenty-eight day Oral Toxicity in the Rat with QM 552. Data on File Rohm and Haas Company, European Operations, Chesterfield House, Bloomsbury Way, LONDON WC1A 2TP, ENGLAND. QM 552: Bacterial Mutation Assay. Data on File Rohm and Haas Company, European Operations, Chesterfield House, Bloomsbury Way, LONDON WC1A 2TP, ENGLAND. Analysis of metaphase chromosomes obtained from CHO cultured in vitro and treated with QM-552. Rohm and Haas Company, European Operations, Chesterfield House, Bloomsbury Way, LONDON WC1A 2TP, ENGLAND Australian Standard 2161-1978 Industrial Safety Gloves and Mittens (excluding Electrical and Medical Gloves), Standards Association of Australia Publ, Sydney 1978. Australian Standard 1337-1984 Eye Protectors for Industrial Applications, Standards Association of Australia Publ, Sydney 1984.
individual vessels not easily discernible Diffuse beefy red 3 severe Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 4 severe Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
For a synthetic polymer with number average molecular weight (NAMW) > 1000, toxicology data is not required under the Act. None was provided by the notifier. The notified polymer has a NAMW of >1000 and is therefore not expected to traverse biological membranes and constitute a toxicological hazard. Although the notified polymer contains a low level of a hazardous residual monomer and low levels of low molecular weight, no loss by exudation or leaching from the polymer is expected to occur and therefore, they are not expected to present a toxicological threat. 10. ASSESSMENT OF ENVIRONMENTAL EFFECTS As the synthetic polymer under assessment has a predominant molecular weight greater than 1000, then data on toxicology (Part C) is not required. 11. ASSESSMENT OF ENVIRONMENTAL HAZARD Hazard from Use From the scenarios presented for the three phases of the polymer's life (manufacture, formulation in paint and paint application), none of the polymer would be expected to be released to the environment in the first two phases. The company expects most of the polymer will be cured onto items that are painted with Crodakyd S99 type paint. They do not expect very much at all to be disposed of by landfill. The captured polymer (in filters etc.)would be expected to cure as a high molecular weight, polymer which is insoluble and will not cross biological membranes. on the assumptions in "Release" above, there could be 62 tonnes of cured polymer disposed to landfill, but no environmental hazard is expected from this, given the nature of the cured polymer. Therefore, the use of Crodakyd S99 should no environmental impact, so long as it is used as stated. Hazard from Manufacture, Handling and Disposal The MSDS is satisfactory for handling, storage, transport and spill-control/disposal of the Crodakyd S99 product. 12. ASSESSMENT OF PUBLIC AND OCCUPATIONAL HEALTH AND SAFETY EFFECTS
5. Standards Australia, 1994, Australian Standard 1336-1994, Recommended Practices for Eye Protection in the Industrial Environment, Standards Association of Australia Publ., Sydney, Australia. 6. Standards Australia, Standards New Zealand 1992, Australian/ New Zealand Standard 1337-1992, Eye Protectors for Industrial Applications, Standards Association of Australia Publ., Sydney, Australia, Standards Association of New Zealand Publ. Wellington, New Zealand. 7. Standards Australia, 1990 Australian Standard 3765 - 1990. Clothing for Protection Against Chemical Hazards, Part 1, Protection against General or Specific Chemicals; Part 2, Limited Protection Against Specific Chemicals, Standards Australia Publ., Sydney, Australia. 8. Standards Australia, 1978. Australian Standard 2161-1978, Industrial Safety Gloves and Mittens (excluding Electrical and Medical Gloves), Standards Association of Australia Publ., Sydney, Australia. 9. National Occupational Health and Safety Commission, [NOHSC:2011(1994)],1994. National Code of Practice for the Preparation of Material Safety Data Sheets, AGPS, Canberra.
will preclude dermal absorption. Whilst the public exposure during application of varnish will require the use of personal protective equipment, the dried varnish should present no possibility of exposure. 8. ENVIRONMENTAL EXPOSURE . Release There is a potential for release of the notified polymer to the environment during the manufacture, transport, secondary processing, and final use stages. At the manufacturing plant, any excess material left after filling the drums will be blended into the next batch. All filter residues are intended to be deposited in secure landfill in accordance with Local, State and Federal regulations. In the case of a spillage, it would be collected and disposed of similarly. Packaging of the aqueous dispersion of the polymer in sealed steel drums minimises the potential for release during transport. Waste from the varnish formulation process would consist of polymer residue remaining in used drums. These are consigned to landfill in accordance with Local, State and Federal regulations. Other possible release will be when painting equipment i.e. brushes, rollers etc. is cleaned and when paint cans containing excess paint are disposed of. The washings are likely to enter the drain with copious quantities of water, followed by treatment at a sewage treatment plant. Empty cans and excess paint in cans are likely to be disposed of with the normal household garbage by landfill. . Fate Most of the notified polymer will be used to coat timber and should have limited environmental exposure once cured. Waste generated during paint manufacture will be consigned to landfill, as well as any unused paint residues in cans. Most of the polymer washed down drains when brushes and rollers etc. are cleaned will be contained in the sewage sludge which will be landfilled or incinerated. The notified chemical is a polymer with low water solubility, degradation or leaching from landfill sites is not expected. Incineration of the notified substance is expected to produce water, and oxides of carbon and nitrogen. 9. EVALUATION OF TOXICOLOGICAL DATA Toxicological data are not required for polymers of NAMW > 1000 according to the Act. 10. ASSESSMENT OF ENVIRONMENTAL EFFECTS No ecotoxicological data were provided, which is acceptable for polymers of NAMW > 1000 according to the Act.
Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to haemorrhage, gross destruction 2 severe
File No: NA/381 Date: October 1996 NATIONAL INDUSTRIAL CHEMICALS NOTIFICATION AND ASSESSMENT SCHEME FULL PUBLIC REPORT Polymer in Acumer 4161 This Assessment has been compiled in accordance with the provisions of the Industrial Chemicals (Notification and Assessment) Act 1989 (the Act), and Regulations. This legislation is an Act of the Commonwealth of Australia. The National Industrial Chemicals Notification and Assessment Scheme (NICNAS) is administered by Worksafe Australia which also conducts the occupational health & safety assessment. The assessment of environmental hazard is conducted by the Department of the Environment, Sport, and Territories and the assessment of public health is conducted by the Department of Health and Family Services For the purposes of subsection 78(1) of the Act, copies of this full public report may be inspected by the public at the Library, Worksafe Australia, 92-94 Parramatta Road, Camperdown NSW 2050, between the hours of 8.30 a.m. and 5.00 p.m. each week day except Thursday when opening is extended to 8.30 p.m. The library is not open on public holidays. For Enquiries please contact the Administration Coordinator at: Street Address: 92 Parramatta Rd Camperdown, NSW 2050, AUSTRALIA Postal Address: GPO Box 58, Sydney 2001, AUSTRALIA Telephone: (61) (02) 9577-9466 FAX (61) (02) 9577-9465 Director Chemicals Notification and Assessment
Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Draize scores (8): 0 Test method: based on OECD Guidelines for Testing Chemicals (6) Result: aqueous solution not a skin irritant in rabbits 9.1.5.1 Eye Irritation (#10) Species/strain: New Zealand rabbit Number/sex of animals: 6 male Observation period: 7 days Method of administration: neutralised by triethanolamine (aqueous solution too corrosive), containing 10.5% active material, 0.1 ml in one eye of each rabbit Draize scores (8): 4.67 (maximum, out of possible 110) Test method: conforms to Journal Officiel de la Rpublique Franaise 24/10/1984 Result: triethanolamine salt irritant 9.1.5.2 Eye Irritation (#11) Species/strain: New Zealand rabbit Number/sex of animals: 6 male Observation period: 7 days Method of administration: neutralised by potassium hydroxide (aqueous solution too corrosive), containing 10.5% active material, 0.1 ml in one eye of each rabbit Draize scores (8): 8 (maximum, out of possible 110) Test method: conforms to Journal Officiel de la Rpublique Franaise 24/10/1984 Result: potassium salt irritant 9.1.5.3 Eye Irritation (#12)
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent areas, details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe
Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids half-closed Swelling with lids half-closed to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe