severe liver injury, adrenal insufficiency, and adverse drug interactions, clinicians should no longer prescribe ketoconazole (Nizoral, Janssen Pharmaceuticals) tablets as a therapy” (FDA, 2013). With the lines of defense dwindling, substitutes need to be produced as a means of compensation either through the bodies self defense mechanism of adaptive mutation or synthetically produced antibiotics. Presence of Candida albicans in body: Commonalities in host organisms are subject to Candida albicans, through skin, mucus membranes, vagina, and stomach house this fungus. Expressing a dimorphic phenotype Candida albicans can express oval shape yeast characteristics as well as branching hypha present in most species of fungi. Living in symbiosis, Candida albicans doesn’t become hyperactive until the depleting of natural bacterial flora is in occurrence causing infection. This could happen through a numerous amount of process, commonly in women that are pregnant the hormonal unbalance could lead to protect biofilm within the vagina to deplete premising C. albacans to grow invasively. The use of prolonged antibiotics in the body since the antibiotics used will kill only the bacteria and not any fungus this allows for C. albicans to gain a foothold over the local mucosa that it inhabits. (J.Graf, 2010) Mutation: Within the mutation of bacteria there is a present structure made reference to a plasmid, “small, double stranded DNA molecules that can exist independently of the
success. 10-100 microliters of toxic solute secretion per strain was acquired and was a direct result of the “F-Factor growth-related response in a minimal medium through the killer factor was produced as cells progressed from late-exponential to early-stationary phase. Protein levels in the extracellular medium mirrored toxin production and an agitated system led to the highest titres of killer factor.” (Hodgson, Button, Walker, 141, pg. 2009, 2003-2012). Attempts to filter the toxin out using gel-filtration chromatography rendered unstable products on temperature increase making it more difficult to contain at room temperature for medical purposes, i.e. 4 degrees Celsius it was stable and well suited but as it was introduced in cultured medium through temperature increase the stability began to dwindle with 5% of toxicity of host cell at 1.8 kDa of molecular weight be the smallest previously recorded making it much more safe than in comparison to the toxin produced by S. cervisiae which has a kDa molecular weight of 20. Reactivity in Candida albacans: results of culturing Through the abilities to spear a defensive nature the mechanism through which K-500 acts through is one that truly captivates. “Affecting the exerted yeast the killer toxin notably leaks K+ and ATP and disruption of macromolecular synthesis and the toxin is thought to arrest cell proliferation in the G1 phase of the cell cycle.” (Hodgson, Button, Walker, 141, pg. 2009, 2003-2012) This extraordinary find was remarkable as it inhibits the growth and replication cycle of somatic cells in organisms from the second origin of which they are produced in mitosis. Inhibits (1,3)-Beta-glucan synthesis through the toxic protein secreted, the wall defense of the yeast is left open and susceptible to