PART 4 –SUMMARY OF EVIDENCE Provide an overview of all key journal articles or research published in the public domain related to the proposed service that is for your application (limiting these to the English language only). Please do not attach full text articles, this is just intended to be a summary. Type of study design* Title of journal article or research project (including any identifier or study lead if relevant) Short description of research (max 50 words)** Website link to journal article or research (if available) Date of Studies on Assessment of Patients with Small Bowel Crohn’s Disease 1. study. Small Bowel (SB) Capsule Endoscopy (CE) in the Management of Established Crohn’s Disease: Clinical Impact, Safety, and Correlation with Inflammatory Biomarkers et al. The study cohort included consecutive 187 patients with established SB CD who underwent Video Capsule Endoscopy (VCE) in 4 tertiary referral centres from January 2008 to October 2013. 2015 2. Prospective cohort study. A prospective 52 week mucosal healing assessment of bowel Crohn's disease as detected by capsule endoscopy. Hall et al. 108 capsule procedures were performed on 43 patients. Based on the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI), 39 (90%) demonstrated active small bowel CD at baseline with 28 (65%) undergoing 52 week assessment. 2014 3. Sub-study of a prospective, randomized, double blind study. Sequential capsule endoscopy of the bowel for follow-up of patients with known Crohn's disease. Niv et al. Consecutive patients with known moderately active CD were prospectively recruited. A control group of 178 non-CD patients was used for comparisons. CD patients were recruited and 19 met the inclusion criteria. A total of 43 CE studies were performed over the time. 2014 Retrospective controlled *
7. Single-centre retrospective study. Small bowel capsule endoscopy for management of Crohn’s disease: A retrospective tertiary care centre experience. Dussault et al. SBCE tests performed in a referral centre from 2008 to 2011; 77 tests were performed in patients with known Crohn’s disease. Six patients were excluded due to capsule test retention. Patients were classified into 4 indication groups: unexplained anaemia; discrepancy between clinical symptoms and morphology, full assessment of Crohn’s disease location and evaluation of mucosal healing. 2012 8. Single-centre retrospective study. Impact of capsule endoscopy on management of inflammatory bowel disease: a single tertiary care centre experience. Long et al. 86 symptomatic Crohn’s patients that underwent CE, 61.6% had therapeutic changes (defined as initiation or discontinuation of any IBD specific medication) in the 3 months after the CE, with 39.5% initiating a new IBD medication. 2011
16. Prospective diagnostic yield study. Capsule Endoscopy Is Superior to Small-bowel Follow-through and Equivalent to Ileocolonoscopy in Suspected Crohn’s Disease. Leighton et al. Eighty patients with signs and/or symptoms of small-bowel Crohn's disease (age, 10-65 years) underwent CE, followed by SBFT and ileocolonoscopy. Readers were blinded to other test results. The primary outcome was the diagnostic yield for inflammatory lesions found with CE before ileocolonoscopy compared with SBFT and ileocolonoscopy. A secondary outcome was the incremental diagnostic yield of CE compared with ileocolonoscopy and CE compared with SBFT. 2014