final retail product. The notifier expects 1 to 3 customers in the first year of import, rising to 4 or 5 customers by 1999. At formulation manufacturing workers are required to open drums of Priazul 2118 and connect them to formulation equipment. The formulation process is typically automated and within a fully enclosed system. Workers may experience direct skin contact if a spill occurs in the formulation or filling lines. Drum cleaning workers drums that have contained Priazul 2118. A drum cleaning worker would be required to wash approximately 5 drums for every tonne of Priazul 2118 imported. Retail workers unpack sealed containers containing Priazul 2118 formulations and pack containers on to shelves. Retail workers will only be exposed to the notified chemical through damaged and leaking containers. A typical formulation will contain Priazul 2118 at 5% (w/v). End users will usually be exposed to formulations containing the notified chemical for short periods of time. The duration and frequency of exposure for end users will vary between hairdressing and beauty salons. Typically, a hair care worker may shampoo up to 20 customers per day resulting in 20 separate exposure incidents should the shampoo contain the notified chemical. No occupational exposure data was provided concerning use of the notified chemical as a metal cleaning substance. 7. PUBLIC EXPOSURE Public exposure to the notified chemical is expected to be high. The primary use of Priazul 2118 will be in domestic hair care and bodywash formulations. The public may also be exposed to Priazul 2118 in hair and beauty salons. Exposure of this nature may once a day on external body surfaces. The formulation may also come into contact with the eyes. The secondary use of Priazul 2118 is in metal cleaning formulations for industrial and commercial applications. Public exposure to the notified chemical via the metal cleaning formulations is unlikely. 8. ENVIRONMENTAL EXPOSURE Release During the formulation process, the notified chemical is lost to waste from the cleaning of equipment and lines, transport equipment and drums. The amount of Priazul 2118 lost to waste is expected to be minimal and overall waste generation is expected to be less than 2%. All waste containing Priazul 2118 generated during normal formulation, packaging and cleaning activities is expected to be disposed of to sewer in a diluted form, with or without pretreatment. Any spillages of the notified chemical that may occur will be contained by either sand, earth or other absorbent material. The high viscosity of the chemical at ambient conditions should
Morphological findings: no abnormalities related to the treatment were observed Test method: according to OECD guidelines (1) LD50: > 2 000 mg.kg-1 Result: Priazul 2102 was of low acute dermal toxicity in rats 9.1.3 Inhalation Toxicity (6) Species/strain: rat/Spraque-Dawley Number/sex of animals: 5/sex Observation period: 14 days Method of administration: animals were exposed (snout only) for four hours to an aerosol of 1.98 mg.L-1 Priazul 2102 in corn oil; approximately 70% of the aerosol mass had a particle size less than 0.9 m Clinical observations: an unkempt appearance was noted for all animals; bodyweight profiles did not differ significantly for control or test animals Mortality: nil Morphological findings: two treated males and one control male had slightly mottled lungs Test method: according to OECD guidelines (1) LC50: > 1 980 mg.m-3. Result: Priazul 2102 was of low inhalational toxicity in rats 9.1.4 Skin Irritation (7) Species/strain: rabbit/New Zealand White Number/sex of animals: 4 female Observation period: 72 hours
Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 1 slight 2 mod. 3 severe Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 1 slight 2 mild 3 mod. 4 severe Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe