Hazardous Impurities: Chemical name: hexanol CAS No.: 104-76-7 Weight percentage: 1-3% Toxic properties: Moderate eye and skin irritant. (Gangolli, 1999) Chemical name: Isobutanol CAS No.: 75-65-0 Weight percentage: 0-0.1% Toxic properties: R11: Highly flammable; R20: Harmful by inhalation (NOHSC, 1999b) Chemical name: t-butyl hydroperoxide CAS No.: 75-91-2 Weight percentage: 0-0.5% properties: Harmful by inhalation, in contact with skin and if swallowed; Moderate to severe skin irritant; Severe eye irritant; In vitro clastogen in Chinese Hamster Ovary cells. (Gangolli, 1999) Chemical name: Hydrolyzable chlorides Weight percentage: 0-0.1% Chemical name: Unidentified impurities Weight percentage: 1-2% Non-hazardous Impurities (> 1% by weight): None Additives/Adjuvants: None 5. USE, VOLUME AND FORMULATION The notified chemical will not be manufactured in Australia, but will be imported by sea in 25 L polyethylene jerry cans and delivered to the customer site. The notified chemical will
Number/sex of animals: 5/sex. Observation period: 15 days. Method of administration: 5 000 mg/kg body weight by gavage Test method: EPA Health Effects Test Guidelines (August, 1982). Mortality: No deaths were recorded over the observation period. Clinical observations: There were no signs of systemic toxicity. Morphological findings: No abnormalities were detected. Comment: There were no adverse effects on bodyweight gain over the observation period. LD50: > 5 000 mg/kg. Result: The notified chemical was of very low acute oral toxicity in rats. 9.1.2 Dermal Toxicity (Food and Drug Research Laboratories Inc, 1985a) Species/strain: Rabbit/New Zealand White. Number/sex of animals: 5/sex. Observation period: 15 days. Method of administration: A single dose of 2 000 mg/kg of test substance was applied under occlusive conditions to the shorn dorsal skin of each animal for a period of 24 hours. Test method: EPA Health Effects Test Guidelines (August, 1982). Mortality: No deaths were recorded over the observation period. Clinical observations: Anorexia, diarrheoa, nasal discharge or soft stools was reported in some male and female rabbits. Morphological findings: No abnormalities were detected. Comment: There were no adverse effects on bodyweight gain over the observation period. LD50: > 2 000 mg/kg. Result: The notified chemical was of low dermal toxicity in rats.
Attachment 1 The Draize Scale for evaluation of skin reactions is as follows: Erythema Formation Rating Oedema Formation Rating No erythema 0 No oedema 0 Very slight erythema (barely perceptible) 1 Very slight oedema (barely perceptible) 1 Well-defined erythema 2 Slight oedema (edges of area well-defined by definite raising 2 Moderate to severe erythema 3 Moderate oedema (raised approx. 1 mm) 3 Severe erythema (beet redness) 4 Severe oedema (raised more than 1 mm and extending beyond area of exposure) 4 The Draize scale for evaluation of eye reactions is as follows: CORNEA Opacity Rating Area of Cornea involved Rating No opacity 0 none 25% or less (not zero) 1 Diffuse area, details of iris clearly visible 1 slight 25% to 50% 2 Easily visible translucent details of iris slightly obscure 2 mild 50% to 75% 3 Opalescent areas, no details of iris visible, size of pupil barely discernible 3 moderate Greater than 75% 4 Opaque, iris invisible 4 severe CONJUNCTIVAE Redness Rating Chemosis Rating Discharge Rating Vessels normal Vessels definitely injected above normal More diffuse, deeper crimson red with individual vessels not easily discernible Diffuse beefy red 0 none 1 slight 2 mod. 3 severe No swelling Any swelling above normal Obvious swelling with partial eversion of lids Swelling with lids Swelling with lids to completely closed 0 none 1 slight 2 mild 3 mod. 4 severe No discharge Any amount different from normal Discharge with moistening of lids and adjacent hairs Discharge with moistening of lids and hairs and considerable area around eye 0 none 1 slight 2 mod. 3 severe IRIS Values Rating Normal 0 none Folds above normal, congestion, swelling, circumcorneal injection, iris reacts to light 1 slight No reaction to light, haemorrhage, gross destruction 2 severe