NA/604 Akypo-Soft 45NV 1. APPLICANT Schwarzkopf Pty Ltd of 20 Rodborough Road FRENCHS FOREST NSW 2086 has submitted a limited notification statement in support of their application for an assessment certificate for Akypo-Soft 45NV. 2. IDENTITY OF THE CHEMICAL Chemical Name: Other Names: Product Name: Chemical Abstracts Service (CAS) Registry No.: Molecular Formula: Structural Formula: O R CH2 O C O CH2 CH2 poly(oxy-1,2-ethanediyl), a-(carboxymethyl)-w- (dodecyloxy)-, sodium salt sodium laureth-6 carboxylate Akypo-Soft 45NV (22% notified chemical) Akypo RLM 45N (22% notified chemical Napro LiveColour (contains 2.475% Akypo-Soft 45NV; ª 0.54% notified chemical) (C2H4O)nC14H28O3.Na O Na x R = C12H25 n=12 x=4 or 5
Molecular Weight: Method of Detection and Determination: Spectral Data: 442-487 the notified chemical was identified by infrared (IR) spectroscopy major characteristic IR peaks identified at the following wavelengths: 2 924, 2 854, 1 732, 1 610, 1 464, 1 350, 1 249, 1 118, 1 042, 949 and 856 cm -1 Comments on Chemical Identity Data from infra-red spectroscopy have been provided for the chemical. The structural formula for the notified chemical indicates that the alkyl chain length ranges from 10-16 carbon atoms. However, the CAS number given corresponds only to the 12 carbon homologue. It is noted that the poly(oxy-1,2-ethanediyl), - (carboxymethyl)-(dodecyloxy)-, compound with chitosan (a complex carbohydrate that is derived from D-glucosamine) is listed on the Australian Inventory of Chemical Substances (AICS). The inventory also contains the sodium salts of some higher homologues: poly(oxy-1,2-ethanediyl), -(carboxymethyl)-(tridecyloxy)-, sodium salt [(C2H4O)nC15H30O3.Na]; poly(oxy-1,2-ethanediyl), -(carboxymethyl)- (tetradecyloxy)-, sodium salt [(C2H4O)nC16H32O3.Na]; and poly(oxy-1,2-ethanediyl), - (carboxymethyl)--(hexadecyloxy)-, sodium salt [(C2H4O)nC18H36O3.Na]. 3. PHYSICAL AND CHEMICAL PROPERTIES The following physical and chemical properties unless specified otherwise are for the product containing the notified chemical at approximately 0.54% Appearance at 20°C and 101.3 kPa: Boiling Point: Density: Vapour Pressure: Water Solubility: Partition Hydrolysis as a Function of pH: Adsorption/Desorption: yellow liquid 100°C (water) 1000 kg.m-3 (water) 2.39 kPa at 20°C > 5 000 mg.L-1 (see comments below) not determined (see comments below)
9.1.1 Oral Toxicity (ref) Species/strain: Number/sex of animals: Observation period: Test Substance: Method of administration: Clinical observations: Mortality: Morphological findings: Test method: LD50: Result: 9.1.2 Skin Irritation (Ref) Species/strain: Number/sex of animals: Observation period: Test Substance: Method of administration: rat/Sprague Dawley 5/sex 14 days RLM 45N a single dose of 2 000 mg.kg-1 of RLM administered by gavage; vehicle was arachis oil BP (concentration not specified) none none none similar to OECD guidelines (ref) > 2 000 mg.kg-1 by implication, the notified chemical was of low acute toxicity when administered orally in a limit test in rats rabbit/Himalayan 3 males up to 4 days Akypo-Soft 45NV (as supplied, 21% notified chemical) 0.5 ml of the test substance was applied to intact skin for 4