pH However, hydrolysis is expected to occur very slowly under environmental conditions. Partition Coefficient (n-octanol/water) Not determined On the basis of its hydro/lipophobic tendencies, the notified polymers are expected to partition between the octanol and water phases. Adsorption/Desorption Not determined Generally, polymers similar to the notified polymers are expected to adsorb to soil, sediments and sludge. However, the notified polymers may have low absorption based on the presence of perfluoroalkyl functionalities which have both hydrophobic and lipophobic tendencies. Dissociation Constant Not determined May have the potential to dissociate under environmental conditions (pH 49). Flash Point > 93 °C (M)SDS Autoignition Temperature Not determined Expected to decompose prior to any autoignition. Explosive Properties Not determined Contains no functional groups that would imply explosive properties Oxidising Properties Not determined Contains no functional groups that would imply oxidative properties Reactivity The notified polymers are expected to be stable under normal conditions of use. Physical hazard classification Based on the submitted physico-chemical data depicted in the above table, the notified polymers are not recommended for hazard classification according to the Globally Harmonised System for the Classification and Labelling of Chemicals (GHS), as adopted for industrial chemicals in Australia. INTRODUCTION AND USE (100%) 5 The notified polymers will not be manufactured in Australia. They will be imported into Australia at individual concentrations up to 30%. (100%) 5 LTD/1671 Year 1 2 3 4 5 Tonnes < 5 < 5 < 5 < 5 < 10 LTD/1672 Year 1 2 3 4 5 Tonnes < 5 < 5 < 5 < 5 < 10 LTD/1673 Year 1 2 3 4 5 Tonnes < 5 < 5 < 5 < 5 < 10 Sydney, Melbourne and Brisbane
Type of Dressing Semi-occlusive. Remarks - Method No significant protocol deviations Lesion Mean Score* Animal No. Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Erythema/Eschar 0 0 0 1 < 24 hours 0 Oedema 0 0 0 0 - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results Very slight erythema was noted in one treated animal immediately after patch removal and at the 30-60 minute scoring interval, and had cleared by the 24 hour observation. No signs of irritation were noted in the other animals. There were no deaths or test substance-related clinical signs or remarkable body weight changes during the study period. The test substance was slightly irritating to the skin. DuPont (2010b) Irritation – eye Notified polymer (LTD/1671, < 25% concentration in water) OECD TG 405 Acute Eye Irritation/Corrosion. Species/Strain Rabbit/New White Number of Animals 3 female Observation Period 72 hours Remarks - Method No significant protocol deviations Lesion Mean Score* Animal No. Maximum Value Maximum Duration of Any Effect Maximum Value at End of Observation Period 1 2 3 Conjunctiva: redness 0 0 0.3 1 < 48 hours 0 Conjunctiva: chemosis 0 0 0 0 - 0 Conjunctiva: discharge 0 0 0 2 < 24 hours 0 Corneal opacity 0 0 0 0 - 0 Iridial inflammation 0 0 0 0 - 0 *Calculated on the basis of the scores at 24, 48, and 72 hours for EACH animal. Remarks - Results A single application of 0.1 mL of the test material to the non-irrigated eye of three rabbits produced conjunctival irritation in all animals. Two treated eyes appeared normal at the 24 hour observation, with the remaining eye showing no signs of irritation at the 48 hour observation. There were no effects from the test substance on the cornea or iris. There were no signs of systemic toxicity and bodyweight gains were with the normal range. The test substance was slightly irritating to the eye. DuPont (2010c) Skin sensitisation – mouse local lymph node assay (LLNA)