untitled h1
8.13 drugs known to be

| UCLA Neuro-Oncology Program  Granisetron Halofantrine Hydrocortixone Hydroxyarginine lfosfamide lmipramine lndinavir lsradipine ltraconazole Ketoconazole Lansoprazole (minor) Letrozole Levobupivicaine Lidocaine Loratadine Losartan Lovastatin Methadone Mibefradil Miconazole Midazolam Mifepristone Mirtazapine (N-demethylation) Montelukast Navelbine Toremifene Trazodone Tretinoin Triazolam Troglitazone Troleandomycin Venlafaxine (N-demethylation) Verapamil Vinblastine   | Repaglinide Retinoic acid Rifampin Risperidone Ritonavir Salmeterol Saquinavir Sertindole Sertraline Sibutramine Sildenafil citrate Simvastatin Sirolimus Sufentanil Tacrolimus Tamoxifen Temazepam Teniposide Terfenadine Testosterone Tetrahydrocannabinol Theophylline Tiagabine Tolterodine Vincristine Warfarin (R-warfarin) Yohimbine Zaleplon (minor pathway) Zatoestron Zileuton Ziprasidone Zolpidem Zonisamide   |                                                                                              |
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| Inducers Carbamazepine Dexamethasone Ethosuximide Glucocorticoids Griseofulvin Nafcillin  Nelfinavir Nevirapine Oxcarbazepine Phenobarbital Phenylbutazone                                                                                                                                                                                                                                                                                                                              | Phenytoin Primidone Progesterone Rifabutin Rifampin Rofecoxib (mild) St John's wort Sulfadimidine Sulfinpyrazone Troglitazone                                                                                                                                                                                                                                                                                              |                                                                                              |
| Inhibitors Amiodarone Anastrozole Azithromycin  Cannabinoids Cimetidine Clarithromycin Clotrimazole                                                                                                                                                                                                                                                                                                                                                                                     |                                                                                                                                                                                                                                                                                                                                                                                                                            | Ketoconazole Metronidazole Mibefradil Miconazole (moderate) Nefazodone Nelfinavir Nevirapine |
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| Cyclosporine Danazol Delavirdine Dexamethasone Diethyldithiocarbamate Diltiazem Dirithromycin Disulfiram Entacapone (high dose) Erythromycin Ethinyl estradiol Fluconazole (weak) Fluoxetine Fluvoxamine Gestodene Grapefruit juice lndinavir lsoniazid ltraconazole   | Norfloxacin Norfluoxetine Omeprazole (weak) Oxiconazole Paroxetine (weak) Propoxyphene Quinidine Quinine Quinupristin and dalfopristin Ranitidine Ritonavir Saquinavir Sertindole Sertraline Troglitazone Troleandomycin Valproic acid (weak) Verapamil Zafirlukast Zileuton   |
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(Adapted from Cytochrome P-450 Enzymes and Drug metabolism. In : Lacy CF, Armstrong LL, Goldman MP, Lance LL eds. Drug Information Handbook 8th **ed. Hudson, OH;**
LexiComp Inc. 2000: 1364-1371)