appendix xii patient version of
laser surgical devices

| Toxicity/Grade                | Original Clinician Language                                                                                                                              | Patient Language Adaptation                                                                                                                                                      |
|-------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ECOG Performance Status 0     | Fully active, able to carry out all prediseaseperformance                                                                                                | I am fully active and able to carry out activities the same                                                                                                                      |
| without restriction           | as before my cancer diagnosis, without any  restrictions                                                                                                 |                                                                                                                                                                                  |
| 1                             | Restricted in physically strenuous activity but ambulatory  and able to carry out work of a light or sedentary nature, eg, light house work, office work | I have difficulty with physically strenuous activity but I  am able to walk and carry out work that is light or  based in one location; such as light house-work or  office-work |
| 2                             | Ambulatory and capable of all selfcare but unable to carry  out any work activities; up and about more than 50%  of waking hours                         | I can walk and take care of myself, but I am not able to carry out work activities; I am up and about more  than half the hours that I am awake                                  |
| 3                             | Capable of only limited selfcare, confined to bed or chair                                                                                               | I am capable only of limited self-care and spend more                                                                                                                            |
| more than 50% of waking hours | than half of the hours that I am aware in bed or in a  chair                                                                                             |                                                                                                                                                                                  |
| 4                             | Completely disabled. Cannot carry on any selfcare; totally                                                                                               | I am completely disabled, cannot carry on any self-care,                                                                                                                         |
| confined to bed or chair      | and am totally confined to a bed or chair                                                                                                                |                                                                                                                                                                                  |  
Questionnaire only required for A-HRSI Scale Responsiveness Substudy (completed February 2020)
appendix xii patient version of
appendix xiii participant global impression

| Very  much  better  (+3)                                                                          |                        |                        |                      |                 |                       |                         |
|---------------------------------------------------------------------------------------------------|------------------------|------------------------|----------------------|-----------------|-----------------------|-------------------------|
| Since you last  completed a  questionnaire,  how would  you rate your  OVERALL  QUALITY  OF LIFE? | Very  much  worse (-3) | Moderately  worse (-2) | A little  worse (-1) | No  change  (0) | A little  better (+1) | Moderately  better (+2) |