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16 appendices

| 16.1                                                                                             | APPENDIX A: PERFORMANCE STATUS CRITERIA ECOG Performance Status Scale                                   | Karnofsky Performance Scale          |                                                              |
|--------------------------------------------------------------------------------------------------|---------------------------------------------------------------------------------------------------------|--------------------------------------|--------------------------------------------------------------|
| Grade                                                                                            | Descriptions                                                                                            | Percent                              | Description                                                  |
| 100                                                                                              | Normal, no complaints, no  evidence of disease.                                                         |                                      |                                                              |
| Normal activity. Fully active, able                                                              |                                                                                                         |                                      |                                                              |
| 0                                                                                                | to carry on all pre-disease                                                                             | Able to carry on normal activity;    |                                                              |
| performance without restriction.                                                                 | 90                                                                                                      | minor signs or symptoms of  disease. |                                                              |
| Symptoms, but ambulatory.  Restricted in physically strenuous  activity, but ambulatory and able | Cares for self, unable to carry on                                                                      |                                      |                                                              |
| to carry out work of a light or  sedentary nature (e.g., light                                   | 70                                                                                                      | normal activity or to do active      |                                                              |
| housework, office work).                                                                         | work.                                                                                                   |                                      |                                                              |
| 80                                                                                               | Normal activity with effort; some  signs or symptoms of disease.                                        |                                      |                                                              |
| 1                                                                                                | Requires occasional assistance,                                                                         |                                      |                                                              |
| In bed <50% of the time.                                                                         | 60                                                                                                      | but is able to care for most of      |                                                              |
| Ambulatory and capable of all                                                                    | his/her needs.                                                                                          |                                      |                                                              |
| 2                                                                                                | self-care, but unable to carry out  any work activities. Up and about  more than 50% of waking hours.   | 50                                   | Requires considerable assistance  and frequent medical care. |
| 40                                                                                               | Disabled, requires special care  and assistance.                                                        |                                      |                                                              |
| 3                                                                                                | In bed >50% of the time. Capable  of only limited self-care, confined  to bed or chair more than 50% of | Severely disabled, hospitalization   |                                                              |
| waking hours.                                                                                    | 30                                                                                                      | indicated. Death not imminent.       |                                                              |
| 20                                                                                               | Very sick, hospitalization  indicated. Death not imminent.                                              |                                      |                                                              |
| 4                                                                                                | 100% bedridden. Completely  disabled. Cannot carry on any selfcare. Totally confined to bed or  chair.                                                                                                         | 10                                   | Moribund, fatal processes  progressing rapidly.              |
| 5                                                                                                | Dead.                                                                                                   | 0                                    | Dead.                                                        |