10 supporting documentation and operational
12 appendices 12.1 appendix a

| ECOG Performance Status Scale                                                                                                                                                             | Karnofsky Performance Scale                                                 |                                                                                 |                                                                        |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------|---------------------------------------------------------------------------------|------------------------------------------------------------------------|
| Grade                                                                                                                                                                                     | Descriptions                                                                | Percent                                                                         | Description                                                            |
| 100                                                                                                                                                                                       | Normal, no complaints, no evidence of  disease.                             |                                                                                 |                                                                        |
| Normal activity. Fully active, able to carry                                                                                                                                              |                                                                             |                                                                                 |                                                                        |
| 0                                                                                                                                                                                         | on all pre-disease performance without  restriction.                        | 90                                                                              | Able to carry on normal activity; minor  signs or symptoms of disease. |
| 80                                                                                                                                                                                        | Normal activity with effort; some signs or  symptoms of disease.            |                                                                                 |                                                                        |
| Symptoms, but ambulatory. Restricted in  physically strenuous activity, but  ambulatory and able to carry out work of  a light or sedentary nature (e.g., light  housework, office work). |                                                                             |                                                                                 |                                                                        |
| 1                                                                                                                                                                                         | 70                                                                          | Cares for self, unable to carry on normal  activity or to do active work.       |                                                                        |
| In bed <50% of the time. Ambulatory and  capable of all self-care, but unable to  carry out any work activities. Up and  about more than 50% of waking hours.                             | 60                                                                          | Requires occasional assistance, but is able  to care for most of his/her needs. |                                                                        |
| 2                                                                                                                                                                                         | 50                                                                          | Requires considerable assistance and  frequent medical care.                    |                                                                        |
| 40                                                                                                                                                                                        | Disabled, requires special care and  assistance.                            |                                                                                 |                                                                        |
| In bed >50% of the time. Capable of only                                                                                                                                                  |                                                                             |                                                                                 |                                                                        |
| 3                                                                                                                                                                                         | limited self-care, confined to bed or chair  more than 50% of waking hours. | 30                                                                              | Severely disabled, hospitalization indicated. Death not imminent.      |
| 20                                                                                                                                                                                        | Very sick, hospitalization indicated. Death  not imminent.                  |                                                                                 |                                                                        |
| 100% bedridden. Completely disabled.                                                                                                                                                      |                                                                             |                                                                                 |                                                                        |
| 4                                                                                                                                                                                         | Cannot carry on any self-care. Totally  confined to bed or chair.           | 10                                                                              | Moribund, fatal processes progressing  rapidly.                        |
| 5                                                                                                                                                                                         | Dead.                                                                       | 0                                                                               | Dead.                                                                  |