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| DAY #                       | DATE-            | TIME                | INITIALS | Blood Pressure | DATE | TIME | INITIALS |
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| DAY #   | DATE   | TIME   | INITIALS   | Blood Pressure   | DATE   | TIME   | INITIALS   |
|---------|--------|--------|------------|------------------|--------|--------|------------|
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md anderson symptom inventory -

Part I. How severe are your symptoms?  
People with cancer frequently have symptoms that are caused by their disease or by their treatment. We ask you to rate how severe the following symptoms have been in the last 24 hours. Please select a number from 0  
| (symptom has not been present) to 10 (the symptom was as bad as you can imagine it could be) for each item.   |                             |    |    |    |    |    |    |    |    |    |    |    |
|---------------------------------------------------------------------------------------------------------------|-----------------------------|----|----|----|----|----|----|----|----|----|----|----|
| Not                                                                                                           | As Bad As You               |    |    |    |    |    |    |    |    |    |    |    |
| Present                                                                                                       | Can Imagine                 |    |    |    |    |    |    |    |    |    |    |    |
| 0                                                                                                             | 1                           | 2  | 3  | 4  | 5  | 6  | 7  | 8  | 9  | 10 |    |    |
| 1.                                                                                                            | Your pain at its WORST?     | O  | o  | o  | O  | o  | o  | o  | o  | o  | o  | o  |
| 2.                                                                                                            | Your fatigue (tiredness) at | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |
| its WORST?                                                                                                    |                             |    |    |    |    |    |    |    |    |    |    |    |
| 3.                                                                                                            | Your nausea at its WORST?   | o  | o  | o  | o  | o  | O  |    |    |    |    |    |
| o                                                                                                             | o                           | o  | o  | o  |    |    |    |    |    |    |    |    |
| 4.                                                                                                            | Your disturbed sleep at its | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 5.                                                                                                            | Your feelings of being      |    |    |    |    |    |    |    |    |    |    |    |
| distressed (upset) at its                                                                                     | o                           | o  | o  | o  | o  | o  | O  | o  | o  | o  | o  |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 6.                                                                                                            | Your shortness of breath at | O  | O  |    |    |    |    |    |    |    |    |    |
| o                                                                                                             | O                           | o  | o  | o  | o  | o  | o  | o  |    |    |    |    |
| its WORST?                                                                                                    |                             |    |    |    |    |    |    |    |    |    |    |    |
| 7                                                                                                             | Your problem with           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |
| remembering things at its                                                                                     |                             |    |    |    |    |    |    |    |    |    |    |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 8.                                                                                                            | Your problem with lack of   | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  | O  |
| appetite at its WORST?                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 9.                                                                                                            | Your feeling drowsy         | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |
| (sleepy) at its WORST?                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 10. Your having a dry mouth at                                                                                | o                           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| its WORST?                                                                                                    |                             |    |    |    |    |    |    |    |    |    |    |    |
| 1. Your feeling sad at its                                                                                    | O                           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 12. Your vomiting at its                                                                                      | o                           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 13. Your numbness or tingling                                                                                 | O                           | o  | o  | O  | o  | o  | o  | o  | o  |    |    |    |
| o                                                                                                             | o                           |    |    |    |    |    |    |    |    |    |    |    |
| at its WORST?                                                                                                 |                             |    |    |    |    |    |    |    |    |    |    |    |
| 14. Your weakness on one side                                                                                 | o                           | o  | o  | o  | o  | O  | o  | o  | o  | o  | o  |    |
| of the body at its W ORST?                                                                                    |                             |    |    |    |    |    |    |    |    |    |    |    |
| 15. Your difficulty                                                                                           |                             |    |    |    |    |    |    |    |    |    |    |    |
| understanding at its                                                                                          | o                           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |
| 16. Your difficulty speaking                                                                                  | O                           | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| (finding the words) at its                                                                                    |                             |    |    |    |    |    |    |    |    |    |    |    |
| WORST?                                                                                                        |                             |    |    |    |    |    |    |    |    |    |    |    |  
Date:
Institution:
Participant Initials:
Hospital Chart \#:
Participant Number:  
| Not                                | As Bad As You            |    |    |    |    |    |    |    |    |    |    |    |
|------------------------------------|--------------------------|----|----|----|----|----|----|----|----|----|----|----|
| Present                            | Can Imagine              |    |    |    |    |    |    |    |    |    |    |    |
| 2                                  | 3                        | 5  | 7  | 10 |    |    |    |    |    |    |    |    |
| 0                                  | 1                        | 4  | 6  | 8  | 9  |    |    |    |    |    |    |    |
| 17.  Your seizures at its WORST?   | O                        | o  | o  | o  | o  | o  | o  | o  | o  | o  | o  |    |
| 18.  Your difficulty concentrating | o                        | o  | o  | o  | o  | O  | o  | o  | o  | O  | o  |    |
| at its WORST?                      |                          |    |    |    |    |    |    |    |    |    |    |    |
| 19.  Your vision at its WORST?     | O                        | O  | o  | o  | O  | O  | o  | o  | o  | o  | o  |    |
| 20. Your change in appearance      | O                        | o  | o  | o  | O  | O  | o  | o  | O  | O  | O  |    |
| at its WORST?                      |                          |    |    |    |    |    |    |    |    |    |    |    |
| 21. Your change in bowel pattern   |                          |    |    |    |    |    |    |    |    |    |    |    |
| (diarrhea or constipation) at      | o                        | o  | o  | o  | o  | o  | o  | o  | o  | o  | O  |    |
| its WORST?                         |                          |    |    |    |    |    |    |    |    |    |    |    |
| 2.                                 | Your irritability at its | O  | O  | o  | o  | O  | O  | o  | o  | o  | o  | O  |
| WORST?                             |                          |    |    |    |    |    |    |    |    |    |    |    |  
Part II. How have your symptoms interfered with your life? Symptoms frequently interfere with how we feel and function. How much have your symptoms interfered with the following items in the last 24 hours?  Please select a number from 0 (symptoms have not interfered) to 10 (symptoms interfered completely) for each item.  
| Did Not                   | Interfered   |    |    |    |    |    |    |    |    |    |    |
|---------------------------|--------------|----|----|----|----|----|----|----|----|----|----|
| Interfere                 | Completely   |    |    |    |    |    |    |    |    |    |    |
| 0                         | 1            | 2  | 3  | 4  | 5  | 6  | 7  | 8  | 9  | 10 |    |
| 2. General activity?      | o            | O  | o  | o  | o  | O  | o  | o  | o  | o  | o  |
| 2. Mood?                  | O            | o  | o  | o  | O  | O  | o  | o  | o  | o  | o  |
| 25.  Work (including work | O            | O  | o  | o  | O  | O  | o  | o  | O  | o  | o  |
| around the house)?        |              |    |    |    |    |    |    |    |    |    |    |
| 2. Relations with other   | O            | o  | o  | o  | O  | O  | o  | O  | o  | O  | O  |
| people?                   |              |    |    |    |    |    |    |    |    |    |    |
| 27. Walking?              | o            | o  | o  | o  | o  | o  | o  | o  | O  | o  |    |
| o                         |              |    |    |    |    |    |    |    |    |    |    |
| 2. Enjoyment of life?     | O            | o  | o  | o  | o  | O  | o  | o  | o  | O  | o  |
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Abbreviated Title:  Ph II Sunitinib CNS Sarcomas Version Date: 05-30-18  
  
13.5   M ANAGEMENT OF H YPERTENSION I NDUCED BY VEGF I NHIBITORS