Opium tincture: Indications, Side Effects, Warnings - Drugs.com Know what to ask with our GIST Doctor Discussion Guide Opium tincture Brand Name: Generic only. No brands available. Overview Opium tincture is used for: Treating diarrhea. Opium tincture is an opiate. It works by decreasing intestinal muscle contractions, which helps to reduce diarrhea. Do NOT use opium tincture if: you are allergic to any ingredient in opium tincture or any other opium- or morphine-related medicine (eg, codeine) you are taking sodium oxybate (GHB) you have severe bowel motility problems (eg, paralytic ileus), diarrhea due to poisoning, or severe diarrhea associated with antibiotic use (pseudomembranous colitis) you have severely slow or difficult breathing or severe asthma, or you are having an asthma attack Contact your doctor or health care provider right away if any of these apply to you. Slideshow Prescription Drug Addiction - Top 18 Facts for You and Your Family Before using opium tincture: Some medical conditions may interact with opium tincture.

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines or other substances if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems if you have a history of recent head injury, increased pressure in the brain, brain blood vessel problems, growths in the brain (eg, tumors), or seizures if you have a history of heart problems, low blood pressure, liver or kidney problems, an underactive thyroid, adrenal gland problems (eg, Addison disease), stomach or bowel problems, gallbladder problems, inflammation of the pancreas, a blockage of the bladder or bowel, an enlarged prostate, or the blood disease porphyria if you have a history of drug or alcohol abuse, mood or mental problems, or suicidal thoughts or behavior Some MEDICINES MAY INTERACT with opium tincture.

Tell your health care provider if you are taking any other medicines, especially any of the following: Cimetidine, furazolidone, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, chlorpromazine), or sodium oxybate (GHB) because the risk of side effects such as severe drowsiness, slow or difficult breathing, confusion, and seizures may be increased Buprenorphine, butorphanol, nalbuphine, naltrexone, or pentazocine because the effectiveness of opium tincture may be decreased This may not be a complete list of all interactions that may occur. Ask your health care provider if opium tincture may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How to use opium tincture: Use opium tincture as directed by your doctor. Check the label on the medicine for exact dosing instructions. Opium tincture may be taken with or without food. Use the dropper that comes with opium tincture to measure your dose.

Ask your pharmacist for help if you are unsure of how to measure your dose. If you miss a dose of opium tincture and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Ask your health care provider any questions you may have about how to use opium tincture. Important safety information: Opium tincture may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to opium tincture. Using opium tincture alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking opium tincture. Opium tincture will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Opium tincture may cause dizziness, lightheadedness, or fainting.

Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using opium tincture. Use opium tincture with caution in the ELDERLY because they may be more sensitive to its effects. Use of opium tincture is not recommended in CHILDREN. Safety and effectiveness have not been confirmed. PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking opium tincture, discuss with your doctor the benefits and risks of using opium tincture during pregnancy. It is unknown if opium tincture is excreted in breast milk. If you are or will be breast-feeding while you are using opium tincture, check with your doctor or pharmacist to discuss the risks to your baby.

When used for long periods of time or at high doses, opium tincture may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if opium tincture stops working well. Do not take more than prescribed. When used for long periods of time or at high doses, some people develop a need to continue taking opium tincture. This is known as DEPENDENCE or addiction. If you suddenly stop taking opium tincture, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. Possible side effects of opium tincture: All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Constipation; dizziness; drowsiness; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating; fast or slow heartbeat; seizures; severe dizziness, lightheadedness, or fainting; slowed or difficult breathing; tremor; vision changes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA . If OVERDOSE is suspected: Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center , or emergency room immediately. Symptoms may include cold and clammy skin; confusion; loss of consciousness; seizures; severe drowsiness, dizziness, or lightheadedness; slow breathing; slow heartbeat.

Proper storage of opium tincture: Store opium tincture at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep opium tincture out of the reach of children and away from pets. General information: If you have any questions about opium tincture, please talk with your doctor, pharmacist, or other health care provider. Opium tincture is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine. This information should not be used to decide whether or not to take opium tincture or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about opium tincture.

It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to opium tincture. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using opium tincture. Review Date: January 6, 2017 Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

opium tincture oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD 27 Uses This medication is used to treat diarrhea . It helps to decrease the number and frequency of bowel movements . It works by slowing the movement of the intestines . Opium belongs to a class of drugs known as narcotic pain relievers, but this medication acts mainly to slow the gut. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. A very weak solution of this drug may also be used to treat severe withdrawal symptoms in infants born to mothers who were addicted to narcotics during pregnancy . How to use opium tincture Take this medication by mouth , usually 4 times daily or as directed by your doctor. It may be taken with food or meals if stomach upset occurs. Carefully measure each dose using the dropper provided. If your medication comes in an oral dosing syringe, use the syringe to measure the dose. Do not inject the medication.

The dose may be mixed with a small amount of water just before taking. Dosage is based on your medical condition and response to therapy. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as sweating , nausea , vomiting , restlessness) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away. Though very unlikely, abnormal drug-seeking behavior ( addiction ) is possible with this medication. Do not increase your dose, take it more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed. When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well. Diarrhea can sometimes cause a severe loss of body water ( dehydration ). It is important that you drink the proper amount of fluids and minerals ( electrolytes ) to prevent this effect.

Tell your doctor right away if you develop signs of dehydration (e.g., extreme thirst, decreased urination, muscle cramps , weakness , fainting ). You may also need to change to a bland diet during this time to reduce irritation to your stomach / intestines . Consult your doctor or pharmacist for more information. Inform your doctor if your condition does not improve in a few days. What conditions does opium tincture treat? Side Effects Nausea, vomiting, lightheadedness, dizziness , drowsiness, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: slow/shallow breathing, fainting, vision changes, mental/mood changes. Tell your doctor right away if any of these rare but very serious side effects occur: severe stomach/ abdominal pain , painful/difficult urination, seizures . A very serious allergic reaction to this drug is rare.

However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction , including: rash , itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing . This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. List opium tincture side effects by likelihood and severity. Precautions Before taking tincture of opium, tell your doctor or pharmacist if you are allergic to it; or to other narcotics (e.g., codeine, morphine ), or to papaverine ; or if you have any other allergies . This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. This medication should not be used if you have certain medical conditions.

Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., respiratory depression ), intoxication with alcohol or medications that depress the nervous system or your breathing (CNS/respiratory depressants such as tranquilizers /sedatives). Since this medication slows the gut, it should not be used to treat diarrhea caused by poisoning until the toxin is removed from your gut. Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury , tumor, increased intracranial pressure ), heart problems (e.g., irregular heartbeat ), lung diseases (e.g., asthma, emphysema, chronic obstructive pulmonary disease -COPD), stomach/intestinal bleeding, disease of the pancreas ( pancreatitis ), mental/ mood disorders (e.g., toxic psychosis), a certain spinal problem (kyphoscoliosis), gallbladder disease, personal or family history of regular use/abuse of drugs/alcohol, kidney disease , liver disease (e.g., cirrhosis), adrenal gland problem (e.g., Addison's disease ), difficulty urinating (e.g., due to enlarged prostate ), underactive thyroid ( hypothyroidism ).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive its side effects, especially slow/shallow breathing and drowsiness. Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time. Tell the doctor right away if you notice any symptoms in your newborn baby such as slow/shallow breathing, irritability, abnormal/persistent crying, vomiting, or diarrhea. This drug passes into breast milk. Consult your doctor before breast-feeding.

What should I know regarding pregnancy, nursing and administering opium tincture to children or the elderly? Interactions Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. This drug should not be used with the following medications because very serious interactions may occur: naltrexone, pramlintide. If you are currently using any of the medications listed above, tell your doctor or pharmacist before starting tincture of opium. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: cimetidine, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine).

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about using those products safely. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Does opium tincture interact with other medications? Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away.

US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slowed breathing, slow heartbeat, severe dizziness/drowsiness, fainting, muscle weakness. Notes Do not share this medication with others. It is against the law. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Storage Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Information last revised July 2016. Copyright(c) 2016 First Databank, Inc. Images Sorry.

No images are available for this medication. Add to Cabinet Add Adderall to my medicine cabinet. I am opium tincture: Facts About Side Effects and Dosage Pharmacy Author: Omudhome Ogbru, PharmD Omudhome Ogbru, PharmD Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99. Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD Charles Patrick Davis, MD, PhD Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston).

He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications. Respiratory depression and physical and psychological dependence also occur. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Opium tincture is odorless oral liquid containing 10 mg of anhydrous morphine per one ml. STORAGE: Store tincture of opium at room temperature between 68 F to 77 F (20 C to 25 C). DOSING: Adults: Take 0.6 ml by mouth 4 times a day not to exceed 6 ml per day. Children: Safe and effective use of opium tincture is not established in children. DRUG INTERACTIONS: Opium tincture should not be used with medications like naltrexone and buprenorphine because they increase sedation and lower beneficial effect of opium tincture. Opium tincture contains morphine.

Morphine should be avoided in patients treated with monoamine oxidase inhibitors ( MAOI ) due to enhance toxicity of morphine including confusion , high blood pressure , tremor, hyperactivity , coma , and death. Drugs in this class include isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline ( Eldepryl ), and procarbazine ( Matulane ), and linezolid (Zyvox). Morphine should not be administered within 14 days of stopping an MAOI. Medically Reviewed by a Doctor on 9/14/2015 Opium Tincture Opium Tincture Home › Opium Tincture Opium Tincture Opium tincture is an orally administered anti-diarrhea medication that works to decrease bowel movements by slowing the movement of the intestines. The medication is free from any unpleasant odor and comes in a reddish-brown solution that is taken orally. Each 100mL dose of opium tincture contains 1g of anhydrous morphine, alcohol and water.

The medication works by toning the long segments of the longitudinal muscle and inhibiting propulsive contraction of the circular and longitudinal muscles. The medication also has an analgesic effect which is due to the morphine content of the tincture. However, small doses of the opium tincture will not produce analgesic effects and will actually work to reduce diarrhea. Opium tincture is well absorbed into the gastrointestinal tract and rapidly metabolized in the liver. The drug is later excreted in the urine as morphine-3-glucuronide as well as morphine-3-6-diglucuronide and also opium tincture. The half life is about 36 hours which means that during this time, about 50% of the dose is excreted. Opium Tincture is an medicine that is taken orally. Opium tincture is not recommended for use in children and is not safe for use in controlling diarrhea that is the result of poisoning. Once the toxic material or substance that has caused the poisoning has been eliminated from the gastrointestinal tract, opium tincture may be incorporated into the treatment regimen to help prevent the diarrhea from further causing problems.

This medication should not be administered to pregnant or nursing women, children, those who are taking central nervous system depressants or the elderly. Talk with your doctor about any other medications that you may be taking prior to taking opium tincture. If you are addicted to drugs, have a family history of addiction or have been addicted to drugs in the past, opium tincture may not be suitable for your medical treatment as the drug could cause further addiction. Opium tincture is typically prescribed in .6mL doses to be taken orally every 6 hours. It is not recommended that this medication be taken for a prolonged period of time as it could cause addiction or physical dependence. Talk with your doctor about the side effects, risk of addiction and other questions you may have before taking opium tincture for the treatment of diarrhea or other problems. What is Opium Tincture? - Though opium is an addictive and dangerous drug, in very small portions mixed with alcohol and other ingredients, called opium tincture, it can be used to treat diarrhea. Name Opium - Side Effects, Dosage, Interactions | Everyday Health Opium 1 Review Opium preparation is an opioid. An opioid is sometimes called a narcotic.

Opium is derived from the seed pod of a poppy plant. It works by increasing smooth muscle tone and decreasing fluid secretions in the intestines. This slows the movement of bowel matter through the intestines. Opium preparation (sometimes called "opium tincture") is used to treat diarrhea. Opium preparation may also be used for purposes not listed in this medication guide. Do not use this medicine if the safety seal on the cap is broken or missing. You should not use opium preparation if you are allergic to morphine, or if you have a seizure disorder. Opium preparation should not be given to treat diarrhea that is caused by poisoning (until the toxin is no longer in the digestive tract). Do not use this medicine if the safety seal on the cap is broken or missing. You should not use opium preparation if you are allergic to morphine, or if you have: a seizure disorder; or diarrhea that is caused by poisoning (until the toxin is no longer in the digestive tract).

To make sure opium preparation is safe for you, tell your doctor if you have: any type of breathing problem or lung disease; a history of stomach problems; a history of head injury, brain tumor, or seizures; liver or kidney disease; enlarged prostate, urination problems; or problems with your gallbladder, adrenal gland, or thyroid. Opium preparation is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated. Opium preparation may be habit-forming when used over a long period of time. Never share opium preparation with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away opium preparation is against the law. FDA pregnancy category C. It is not known whether opium preparation will harm an unborn baby. Tell your doctor if you are pregnant. Opium preparation can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Opium Side Effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using opium preparation and call your doctor at once if you have: weak or shallow breathing; dizziness, drowsiness; or itching. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Opium Interactions Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with opium preparation. Check your food and medicine labels to be sure these products do not contain alcohol. Avoid using any other anti-diarrhea medications that your doctor has not prescribed. Opium preparation may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects.

Ask your doctor before taking opium preparation with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Other drugs may interact with opium preparation, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Opium Dosage This medication is usually taken 1 to 4 times daily to treat diarrhea. Follow all directions on your prescription label. Opium preparation can slow or stop your breathing. Never use opium preparation in larger amounts, or for longer than prescribed. Each opium preparation contains a different amount of opium. If you switch from using one opium preparation to using another, your dose will not be the same. Some opium preparations are much stronger than others, and taking too much opium may cause serious harm. Do not stop using opium preparation suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using opium preparation. Store at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An opium preparation overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, and fainting. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Copyright 1996-2017 Cerner Multum, Inc. Latest Update: 5/16/2016, Version: 2.01 Opium Tincture - FDA prescribing information, side effects and uses Opium Tincture Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here. DESCRIPTION Opium Tincture, USP (Deodorized), is for oral administration. It is freed from unpleasant odor or nauseating substances by “denarcotization” with a petroleum distillate.

Opium Tincture is a clear, reddish-brown hydroalcoholic solution. Each 100 mL contains 1 g of anhydrous morphine (represents the equivalent of 10 g of Powdered Opium, USP), alcohol, 19%, and water. Opium has a very characteristic odor and a very bitter taste. The opiates are the most effective and prompt-acting nonspecific antidiarrheal agents. CLINICAL PHARMACOLOGY The opiates act by enhancing tone in the long segments of longitudinal muscle and by inhibiting propulsive contraction of both circular and longitudinal muscles. Clinical evidence indicates that the analgesic activity of opium preparations is due to their morphine content. Relatively small doses that do not produce significant analgesia are effective in controlling diarrhea. The papaverine content of the mixed alkaloids is too small to have demonstrable spasmolytic activity. Slideshow Upcoming Joint Replacement? Your 13 Most Common Questions Answered Following oral administration, morphine is well absorbed from the gastrointestinal tract. It is rapidly metabolized following oral administration, however, and plasma levels of unconjugated morphine are lower than those achieved after parenteral administration.

Like other narcotic analgesics, opium preparations are metabolized in the liver. Morphine undergoes conjugation with glucuronic acid at the 3-hydroxyl group. Secondary conjugation may also occur at the 6-hydroxyl group to form the 3,6-diglucuronide. Morphine is excreted in the urine mainly as morphine-3-glucuronide and smaller amounts of morphine-3,6-diglucuronide and unchanged drug. Approximately 75% of a dose of morphine is excreted in the urine within 48 hours. INDICATIONS AND USAGE Opium Tincture is useful for the treatment of diarrhea. CONTRAINDICATIONS This preparation is not recommended for use in children. It should not be used in diarrhea caused by poisoning until the toxic material is eliminated from the gastrointestinal tract. WARNINGS Addiction can result from opium usage. Opium preparations should be given in the smallest effective dose and as infrequently as possible to minimize the development of tolerance and physical dependence.

PRECAUTIONS General – Opium should be used with caution in the elderly, in debilitated individuals, and in patients with increased intracranial pressure, cerebral arteriosclerosis, hepatic cirrhosis or liver insufficiency, gastrointestinal hemorrhage, myxedema, emphysema, and bronchial asthma. Drug Interactions – When preparations containing opium are administered in combination with other drugs, the cautions applicable to each ingredient should be borne in mind. Reduced dosage is indicated in poor-risk patients, in the very young or very old patient, and in those who are receiving other central-nervous system depressants. Usage in Pregnancy - Pregnancy Category C – Animal reproduction studies have not been conducted with Opium Tincture, USP (Deodorized). It is also not known whether Opium Tincture, USP (Deodorized), can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Opium Tincture, USP (Deodorized), should be given to a pregnant woman only if clearly needed. Nursing Mothers – Caution should be exercised when Opium Tincture, USP (Deodorized), is administered to a nursing woman.

Usage in Children – Safety and effectiveness in children have not been established. See CONTRAINDICATIONS . Adverse Reactions Constipation, nausea, and vomiting may occur in some patients. Pruritus and urticaria have been observed. DRUG ABUSE AND DEPENDENCE Controlled Substance – Opium Tincture, USP (Deodorized), is a Schedule II drug. See WARNINGS . OVERDOSAGE Signs and Symptoms – Symptoms of toxicity are those of morphine and alcohol, such as nausea, vomiting, miosis, cool and clammy skin, respiratory and CNS depression, bradycardia, hypotension, and skeletal muscle flaccidity. Noncardiogenic pulmonary edema may develop after opioid overdose and monitoring of heart filling pressure may be helpful. Ethanol has been demonstrated to cause hypoglycemia in children or adults with limited glycogen stores. In severe overdosage, apnea, circulatory collapse, cardiac arrest, and death may occur. Treatment – To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the Physicians’ Desk Reference (PDR).

In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient. Initial management of opioid overdose should emphasize establishment of a secure airway and support of ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient’s vital signs, blood gases, serum electrolytes, blood glucose, etc. Naloxone antagonizes most effects of opioids. Protect the airway as naloxone may induce vomiting. Since naloxone has a shorter duration of action than opioids, repeated doses may be needed. In patients who abuse opioids chronically, a withdrawal syndrome may be manifest on administration of naloxone. This may include yawning, tearing, restlessness, sweating, dilated pupils, piloerection, vomiting, diarrhea, and abdominal cramps. This syndrome usually abates quickly as the effect of naloxone dissipates. Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed.

Since Opium Tincture can delay gastric emptying, evacuation of the stomach may be beneficial. Safeguard the patient’s airway when employing gastric emptying or charcoal. Monitor for and treat hypoglycemia. The use of forced diuresis, peritoneal dialysis, hemodialysis or charcoal hemoperfusion has not been established to be beneficial. DOSAGE AND ADMINISTRATION Usual Adult Dose – 0.6 mL orally 4 times a day. HOW SUPPLIED Opium Tincture, USP (Deodorized), is supplied as: NDC 62559-153-04 Bottles of 4 fl oz Dispense in tightly closed containers. Store at controlled room temperature, 68° to 77°F (20° to 25°C) (see USP). Manufactured by: Opium (Oral Route) Description and Brand Names - Mayo Clinic Description and Brand Names Drug information provided by: Micromedex Canadian Brand Name Pantopon Descriptions Opium tincture is used to treat diarrhea. This medicine belongs to the group of medicines called narcotics.

When a narcotic is used for a long time, it may become habit-forming, causing mental or physical dependence. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tincture Before Using Portions of this document last updated: Dec. 01, 2015 Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Opium (Oral Route) Before Using - Mayo Clinic Before Using Before Using Drug information provided by: Micromedex In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of opium tincture in the pediatric population. Use in children is not recommended. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of opium tincture in the elderly. However, elderly patients are more likely to have age-related liver, lung, or breathing problems which may require caution for patients receiving opium tincture. Pregnancy All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breastfeeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Drug Interactions Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.

In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Naltrexone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfentanil Tapentadol Other Interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse, history of or Brain disease (e.g., cerebral arteriosclerosis) or Breathing problems (e.g., asthma, emphysema) or Drug dependence, especially narcotic abuse or dependence, or history of or Head injuries or opium tincture oral Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction Current Rating: 5 Comment: Truly a "miracle drug." Have used it for thirty years due to Crohn's disease with short-bowel syndrome. As for the cost, contact the manufacturer: Marathon Pharmaceuticals for assistance --- get the contact information from the "Oley Foundation" [excellent non-profit ogranization in Albany, NY serving patients and families who need to supplement their nutrition via intrave ... Show Full Comment Comment: Truly a "miracle drug." Have used it for thirty years due to Crohn's disease with short-bowel syndrome.

As for the cost, contact the manufacturer: Marathon Pharmaceuticals for assistance --- get the contact information from the "Oley Foundation" [excellent non-profit ogranization in Albany, NY serving patients and families who need to supplement their nutrition via intravenous and/or other means of non-food supplementation. Phone number for Oley Foundation: 518-262-5079] - Just ask the Oley Foundation for the contact information at Marathon Pharmaceuticals for assistance in regards to paying for the tincture of opium. Keep the faith & may God bless all of you! -- "Jerri1031" Current Rating: 4 Comment: I was put on this drug for severe diarrhea following Gastric Bypass surgery. My surgeon thought my problem was my gallbladder and removed it, but it didn't help. Was taking up to 20 Lomotil pills a day and Percocet for pain. Would be late for work because of having to stop to use the restroom 3-4 times on my 20 minute drive from home. Went through several different meds before doc tried this. ...

Show Full Comment Comment: I was put on this drug for severe diarrhea following Gastric Bypass surgery. My surgeon thought my problem was my gallbladder and removed it, but it didn't help. Was taking up to 20 Lomotil pills a day and Percocet for pain. Would be late for work because of having to stop to use the restroom 3-4 times on my 20 minute drive from home. Went through several different meds before doc tried this. I am estatic! No more accidents or nasty gas station bathrooms. Still have problems here and there, but nothing like before. Current Rating: 3 Comment: I have been suffering for over 15 years with bowel incontinance, colorectal cancer in 1994 taking a large section of the large colon, bowel obstruction in 2009 taking a large section of my small intestin. I have taken every drug known to man during all of this, both perscribed & OTC, I was living on boxes Imodium AD & Lomitil. Last Dec 2009 I was rushed to the hospital with sever dydration ...

Show Full Comment Comment: I have been suffering for over 15 years with bowel incontinance, colorectal cancer in 1994 taking a large section of the large colon, bowel obstruction in 2009 taking a large section of my small intestin. I have taken every drug known to man during all of this, both perscribed & OTC, I was living on boxes Imodium AD & Lomitil. Last Dec 2009 I was rushed to the hospital with sever dydration and low potassium from all the chronic diarrhea not mention the 98 pounds lost in 7 months, I was hopitalized for 4 days and was put on Opium Tincture, the taste is so nasty but you get used to it, this actually started to slow the diarrhea down. It was working really well and I was able to leave my house without wearing a depend diaper, but this past week the chronic diarrhea has return and the opium is not slowing it down as well as it has been. Also the cost is outragious, it is shamefull that the only drug that helps people with this disability has to cost an arm and a leg. Not having medical Ins.

it cost me over 300.00 for one small bottle, so I feel for the people who can not afford this and have to still live in a horrible amount of pain and are a prisoner in their own homes cause they can not go out with out having a major attack of diarrhea, you have no warning at all. Current Rating: 5 Comment: I have had colitis for 40 years. It got much worse after radiation for uterine cancer. Diarrhea at least 30 times in a 24 hr period.I have been taking this drug for almost 10 years. I tried everything before my doctor tried this one. Finally I have relief. Diarrhea still breaks thru every couple of months for days then I get it back under control. I now take about .4 ml approx 8 to 10 times a day. ... Show Full Comment Comment: I have had colitis for 40 years. It got much worse after radiation for uterine cancer. Diarrhea at least 30 times in a 24 hr period.I have been taking this drug for almost 10 years. I tried everything before my doctor tried this one. Finally I have relief.

Diarrhea still breaks thru every couple of months for days then I get it back under control. I now take about .4 ml approx 8 to 10 times a day. Works much better than a few larger doses. I take it in the morning when I wake up, at night before I go to bed and before and after every meal. Also in the middle of the night if I can't get it under control. I wouldn't be able to leave my house without this. Its wonderful.

Question: In medicine, how was a tincture of opium known?
Answer: LAUDANUM