アデノ随伴ウイルス
↑ Handa H, Carter BJ (July 25, 1979). “Adeno-associated virus DNA replication complexes in herpes simplex virus or adenovirus-infected cells”. The Journal of Biological Chemistry 254 (14): 6603–10. PMID 221504. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=221504.
↑ Yalkinoglu AO, Heilbronn R, Bürkle A, Schlehofer JR, zur Hausen H (June 1, 1988). “DNA amplification of adeno-associated virus as a response to cellular genotoxic stress”. Cancer Research 48 (11): 3123–9. PMID 2835153. http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=2835153.
↑ Yakobson B, Koch T, Winocour E (April 1, 1987). “Replication of adeno-associated virus in synchronized cells without the addition of a helper virus”.
ヒトにおいて、AAVによって惹起される免疫応答は明らかに限定的であることから、AAVは特に遺伝子治療専門家の興味の対象である。この要因は、免疫関連症状の発生リスクを低減する一方で、ベクターの形質導入の効率性に肯定的に影響するであろう。
Cytotoxic responses would imply the involvement of CD4+ T helper cells in the response to AAV and in vitro data from human studies suggests that the virus may indeed induce such responses including both Th1 and Th2 memory responses. A number of candidate T cell stimulating epitopes have been identified within the AAV capsid protein VP1, which may be attractive targets for modification of the capsid if the virus is to be used as a vector for gene therapy.