アデノ随伴ウイルス
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↑ Fischer AC, Beck SE, Smith CI, et al. (December 2003). “Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques”.
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↑ Nicklin SA, Buening H, Dishart KL, et al. (September 2001). “Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells”. Molecular Therapy 4 (3): 174–81. doi:10.1006/mthe.2001.0424. PMID 11545607.
↑ Rabinowitz JE, Xiao W, Samulski RJ (December 1999). “Insertional mutagenesis of AAV2 capsid and the production of recombinant virus”. Virology 265 (2): 274–85. doi:10.1006/viro.1999.0045. PMID 10600599.
↑ Shi W, Bartlett JS (April 2003). “RGD inclusion in VP3 provides adeno-associated virus type 2 (AAV2)-based vectors with a heparan sulfate-independent cell entry mechanism”. Molecular Therapy 7 (4): 515–25. doi:10.
“Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells”. Journal of Virology 76 (22): 11530–40. doi:10.1128/JVI.76.22.11530-11540.2002. PMC 136795. PMID 12388714. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC136795/.
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↑ http://www.fred.psu.edu/ds/retrieve/fred/investigator/cmm10
↑ Gao GP, Alvira MR, Wang L, Calcedo R, Johnston J, Wilson JM (September 2002). “Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy”.
Although AAV2 is the most popular serotype in various AAV-based research, it has been shown that other serotypes can be more effective as gene delivery vectors. For instance AAV6 appears much better in infecting airway epithelial cells, AAV7 presents very high transduction rate of murine skeletal muscle cells (similarly to AAV1 and AAV5), AAV8 is superb in transducing hepatocytes and AAV1 and 5 were shown to be very efficient in gene delivery to vascular endothelial cells.
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↑ Pajusola K, Gruchala M, Joch H, Lüscher TF, Ylä-Herttuala S, Büeler H (November 2002).
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↑ Chen S, Kapturczak M, Loiler SA, et al. (February 2005). “Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors”. Human Gene Therapy 16 (2): 235–47. doi:10.1089/hum.2005.16.235. PMC 1364465. PMID 15761263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364465/.
↑ Kaludov N, Brown KE, Walters RW, Zabner J, Chiorini JA (August 2001). “Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity”.