RNA活性化
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1 2 3 “Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy”.
RNAaは、ベクターを用いた遺伝子の大量発現の代わりに、遺伝子機能を研究するために用いられてきた。これまでの研究により、生体内(in vivo)でのRNAaの存在が証明されており、がんや非がん性疾患の治療に応用できる可能性がある。
2016年6月、英国のMiNA Therapeutics社は、CEBPA(英語版)遺伝子の活性化を試み、肝臓がん患者を対象とした初のsaRNA医薬品MTL-CEBPAの第I相試験の開始を発表した。