鉱質コルチコイド受容体拮抗薬
尿量の増加は、特に治療開始後の初期段階でよく報告されるが、ほとんどが一過性のもので、治療を継続することで減少する傾向にある。鉱質コルチコイド拮抗薬の一般的な副作用には、吐き気や嘔吐、胃痙攣、下痢などが挙げられる。臨床的に有意な高カリウム血症が起こる可能性があるため、定期的に血清カリウムのモニタリングを行う必要がある。高カリウム血症の病態生理の要点は、鉱質コルチコイド拮抗薬がカリウム(K)の排泄を減少させる点にある。
“30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development”. Journal of Endocrinology 234 (1): T125–T140. doi:10.1530/JOE-16-0600. PMC 5488394. PMID 28634268. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488394/.
↑ http://adisinsight.springer.com/drugs/800021527
↑ “Mineralocorticoid receptor antagonists-pharmacodynamics and pharmacokinetic differences”. Curr Opin Pharmacol 27: 78–85. (2016). doi:10.1016/j.coph.2016.02.005. PMID 26939027.
↑ “Nonsteroidal antagonists of the mineralocorticoid receptor”. Curr. Opin. Nephrol. Hypertens. 24 (5): 417–24. (2015). doi:10.1097/MNH.0000000000000147. PMID 26083526.
↑ The Krause/King-Lewis acronym, developed at Naval Medical Center San Diego Archived 2018-07-13 at the Wayback Machine., of MCRA was developed during February 2017 to distinguish between MRA for a specific MRI which are both widely recognized medical acronyms as compared to the use of MRA for mineralocorticoid receptor antagonist type medications which is only used as a medical acronym in the cardiology and nephrology word.
1 2 Clark III, Donald; Guichard; Calhoun; Ahmed (June 2013). “Aldosterone receptor antagonists: current perspectives and therapies”. Vascular Health and Risk Management 9: 321–331. doi:10.2147/VHRM.S33759. PMC 3699348. PMID 23836977. https://www.ncbi.