ソマトスタチン
Florio T, Schettini G (2002). “[Somatostatin and its receptors. Role in the control of cell proliferation]”. Minerva Endocrinol. 26 (3): 91–102. PMID 11753230.
“Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase”. Mol. Endocrinol. 6 (12): 2136–42. (1993). doi:10.1210/me.6.12.2136. PMID 1337145.
“Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney”. Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. (1992). doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48214/.
下垂体からの成長ホルモンおよび甲状腺刺激ホルモンの分泌の抑制
ランゲルハンス島からのインスリンおよびグルカゴンの産生・分泌の抑制
消化管からの栄養吸収の抑制
セクレチン・ガストリン、胃液、胃酸の分泌の抑制
ネプリライシンの活性を高め、アミロイドβの分解を促進
詳細は以下に示す。
Endocrinology 140 (1): 373–80. (1999). doi:10.1210/en.140.1.373. PMID 9886848.
“The somatostatin-28(1-12)-NPAMAP sequence: an essential helical-promoting motif governing prosomatostatin processing at mono- and dibasic sites”. Biochemistry 41 (5): 1630–9. (2002). doi:10.1021/bi011928m. PMID 11814357.
“Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells”. Exp. Hematol. 30 (2): 116–25. (2002). doi:10.1016/S0301-472X(01)00772-X. PMID 11823046.
Simonetti M, Di BC (2002). “Structural motifs in the maturation process of peptide hormones. The somatostatin precursor. I. A CD conformational study”. J. Pept. Sci. 8 (2): 66–79. doi:10.1002/psc.370. PMID 11860030.