上田実 (医学研究者)
8: 259-64, 1997
Nishiguchi H, Hayashi T, Shigetomi T, Ueda M, Tomita T.Changes in intracellular Ca2+ concentration produced by the alteration of intracellular pH in rat parotid acinar cells.Jpn J Physiol. 47: 41-49, 1997
Tohnai I, Yambe M, W.Z.Su, Ueda M, Ohno Y.A case control study of oral cancer in Aichi, Japan -smoking and drinking habits as risk factors- Oral Oncol. 5: 72-75, 1997
Tomaru Y, Nishiguchi H, Hayashi Y, Kaneko R, Tohnai I, Ueda M, Torii S.An evaluation of maxillofacial reconstruction cases after resection of oral cancer. Oral Oncol. 5: 205-208, 1997
Hayashi Y, Tohnai I, Kaneko R, Ueda M.Cervical lymph node metastasis of squamous cel carcinoma of oral cavity. Oral Oncol. 5: 290-293, 1997
(1998年〜)
Nakai H, Niimi A, Ueda M.
Malignant fibrous histiocytoma of the mandible treated by thermo radiotherapy. Hosp Dent Oral Maxillofac Surg. 8: 52-54, 1996
Niimi A, Ueda M, Nagasaka T.Diffuse lobular oncocytic metaplasia of the submandibular gland: a new entity of tumor-like lesion. Hosp Dent Oral Maxillofac Surg. 8: 30-32, 1996
Hata K, Ueda M.Fabrication of cultured epithelium using oral mucosal cells and its clinical applications. Hum Cell. 9: 91-96, 1996
Tohnai I, Ueda M, Kaneda T, Hashimoto K, Sioda S, Sakuda M, Takada K.Primary Clinical Effects of PP Therapy (Cisplatin and Peplomycin) and TPP Therapy (4ʼ-O-tetrahydro pyranyladriamycin, Cisplatin and Peplomycin) for Oral Cancer.Int J Clin Oncol. 1: 139-44, 1996
Tohnai I, Goto Y, Hayashi Y, Ueda M, Kobayashi T, Matsui M.
Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis.J Immunol. 196(10):4164-71, 2016
Hirata M, Ishigami M, Matsushita Y, Ito T, Hattori H, Hibi H, Goto H, Ueda M, Yamamoto A.Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis.Stem Cells Transl Med.5(10):1416-1424, 2016
Hishida S, Ozaki N, Honda T, Shigetomi T, Ueda M, Hibi H, Sugiura Y.Atrophy of submandibular gland by the duct ligation and a blockade of SP receptor in rats.Nagoya J Med Sci.78(2):215-27, 2016
(2017年〜)
Fujio M, Xing Z, Sharabi N, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K.
Tsai CY, Ueda M, Hata K, Horie K, Hibino Y, Sugimura Y, Toriyama K, Torii S.Clinical results of cultured epithelial cell grafting in the oral and maxillofacial region. J Craniomaxillofac Surg. 25: 4-8, 1997
Sumi Y, Hattori H, Hayashi K, Ueda M.Titanium-inlay--a new root-end filling material. J Endod. 23: 121-3, 1997
Matsuyama M, Usami T, Masuda K, Niimi N, Ohta M, Ueda M. Prevention of infection in dental procedures.J Hosp Infect. 35: 17-25, 1997
Hibi H, Ueda M.Occlusal restoration with surgical interventions-osteotomy, implant surgery, and tooth transplantation: a clinical report.J Prosthet Dent. 78: 236-40, 1997
Yamada T, Tohnai I, Ueda M.Oral injury and the use of mouth guards. Soccer, rugby, basketball player in Japanese high school. Jpn J Phys Fitn Sports Med.
Kasuya M, Sawaki Y, Ueda M.The tree test in children with cleft lip and plate-Low grade elementary school- J Craniomaxillofac Surg. 11: 303-307, 2000
Nakai H, Okazaki Y, Ueda M.Clinical evaluation of vascularized bone grafts and osseointegrated implants. J Oral Implantol. 26: 304-8, 2000
Honda M, Yada T, Ueda M, Kimata K.Cartilage formation by cultured chondrocytes in a new scaffold made of poly(L-lactide-epsilon- caprolactone) sponge.J Oral Maxillofac Surg. 58: 767-75, 2000
Ueda M, Sumi Y, Mizuno H, Honda M, Oda T, Wada K, Boo J and Hata K. Tissue engineering:application for maxillofacial surgery.Mater Sci Eng C. 13: 4-7, 2000
Mizuno H, Emi N, Abe A, Takahashi I, Kojima T, Saito H, Matsuno M, Sumi Y, Hata K, Ueda M.
Strategy for maxillofacial bone regeneration using tissue engineering concept.
29th Annual Meeting and Exposition of the Controlled Release Society (2002.7.22-25 Seoul, Korea) Ueda M. Strategy for maxillofacial bone reconstraction using tissue engineering concept.
13th International Alexandria Dental Congress (2002.10.29-11.1 Alexandria, Egypt) Ueda M. Maxillofacial bone regeneration using tissue engineering concept.
Academy of Osseointegration 18th Annual Meeting (2003.2.27-3.1 Boston, U.S.A.) Ueda M, Yamada Y, Ito K, Okazaki Y. Tissue engineered bone using mesenchymal stem cells and platelet-rich plasma.
5th Annual Meeting of Korean Tissue Engineering Society and 1st Korea-Japan Joint Symposium (2003.5.24 Seoul, Korea) Ueda M.
1999年 テイッシュエンジニアリング・名古屋大学出版会
1999年 咀嚼健康法・中公新書
2000年 人体再生・中公新社
2000年 生命医学と生命科学・共立出版
2003年 再生医学とは何か・メデイア出版
2013年 再生医療叢書第8巻・朝倉書店
2019年 驚異の再生医療・扶桑社
2022年 改訂版 驚異の再生医療〜培養上清が世界を救う〜・扶桑社
2nd International Congress on Cranial and Facial Bone Distraction Processes (1999.6.17-19 Paris, France) Ueda M.Biological basis of distraction osteogenesis.
Lecture in Tübingen Univeresity (1999.6.21-25 Germany) Ueda M. Ossification Mechanism in Distraction Osteogenesis-In Vivo and In Vitro Study.
第38回顎顔面形成再建外科学会 (1999.11.4-6 Korea) Ueda M. Biology of distraction osteogenesis with use of osseointegrated implants -in vivo and in vitro study-
Asian Dentech2000 (2000.1.27-30 Hong Kong) Ueda M. Tissue engineering, application for implant surgery.
Pittsburgh Orthopaedic Tissue Engineering Symposium Ueda M.Applications in oral surgery.
International Tissue Engineering Meeting (2000.5.18-20 Austria)Ueda M.
Potential characteristics of stem cells from human exfoliated deciduous teeth compared with bone marrow-derived mesenchymal stem cells for mineralized tissue-forming cell biology.J Endod. 37: 1647-52, 2011
Hibi H, Ueda M.Supraperiosteal transport distraction osteogenesis for reconstructing a segmental defect of the mandible. J Oral Maxillofac Surg. 69: 742-6, 2011
Matsumoto K, Yamamoto N, Hagiwara S, Saito M, Furue H, Shigetomi T, Narita Y, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.Optimization of hyperthermia and dendritic cell immunotherapy for squamous cell carcinoma. Oncol Rep. 25: 1525-32, 2011
Sugiyama M, Iohara K, Wakita H, Hattori H, Ueda M, Matsushita K, Nakashima M.Dental pulp-derived CD31-/CD146- side population stem/progenitor cells enhance recovery of focal cerebral ischemia in rats.
J Biomed Mater Res A. 73: 63-72, 2005
Ito A, Hibino E, Shimizu K, Kobayashi T, Yamada Y, Hibi H, Ueda M, Honda H.Magnetic force-based mesenchymal stem cell expansion using antibody-conjugated magnetoliposomes. J Biomed Mater Res B Appl Biomater. 75: 320-7, 2005
Sojo K, Sawaki Y, Hattori H, Mizutani H, Ueda M.Immunohistochemical study of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2, -4 (BMP-2, -4) on lengthened rat femurs.J Craniomaxillofac Surg.33: 238-45, 2005
Hibi H, Ueda M.Body posture during sleep and disc displacement in the temporomandibular joint: a pilot study. J Oral Rehabil. 32: 85-9, 2005
Seko K, Kagami H, Senga K, Ozeki K, Mizutani H, Ueda M.Effects of ovariectomy and estrogen replacement on rat oral mucosa.
11: 91-9, 2008
Kinoshita K, Hibi H, Yamada Y, Ueda M.Promoted new bone formation in maxillary distraction osteogenesis using a tissue-engineered osteogenic material.J Craniofac Surg. 19: 80-7, 2008
Yamada Y, Nakamura S, Ito K, Kohgo T, Hibi H, Nagasaka T, Ueda M.Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation: clinical application report from a 2-6-year follow-up.Tissue Eng Part A. 14: 1699-707, 2008
(2009年〜)
Yokokoji M, Fujimoto T, Ohya M, Ueda M.Dental implants for an elderly patient with rheumatoid arthritis taking long-term steroids. Asian J Oral Maxillofac Surg. 21: 123-6, 2009
Okabe K, Yamada Y, Ito K, Kohgo T, Yoshimi R, Ueda M.
13th Annual Meeting of Academy of Osseointegration (1998.3.5-7 Atlanta, U.S.A.) Ueda M, Sawaki Y, Oda T. Ridge augmentation by distraction osteogenesis using osseointegrated implants.
Association for Dental Science of the Republic of China (1998.4.10-12 Taiwan)Ueda M. The effect of teeth loss on spatial memory and acetylcholine release from the parietal cortex in aged rats.
The 3rd Japan-China Conference on Oral Biology and Science (1998.8.10-13 China) Ueda M. Bioartificial skin using cultured living cells - the present and the future.
The 6th Japan-Russia Medical Exchange Foundation International Symposium (1998.8.24-25 Khabarovsk, Russia) Ueda M.Clinical results of cultured epithelial grafting.
Hayashi Y, Iwashita T, Murakamai H, Kato Y, Kawai K, Kurokawa K, Tohnai I, Ueda M, Takahashi M. Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.Biochem Biophys Res Commun. 281: 682-9, 2001
Hayashi Y, Tohnai I, Yamamoto N, Fukuhara H, Fukui T, Ueda M, Mizuno M, Yoshida J.Suicide gene therapy with ganciclovir and adeno-associated virus vector containing the herpes simplex virus thymidine kinase gene for human oral squamous cell carcinoma cell lines.Dent Jpn. 37: 74-77, 2001
Sumi Y, Hasegawa T, Miyaishi O, Ueda M.Interface analysis of titanium implants in a human vascularized fibula bone graft. J Oral Maxillofac Surg. 59: 213-6, 2001
Matsuno H, Tohnai I, Mitsudo K, Hayashi Y, Ito M, Shinkai M, Kobayashi T, Yoshida J, Ueda M.
J Oral Maxillofac Surg. 68: 1783-7, 2010
Mizuno H, Kagami H, Mase J, Mizuno D, Ueda M.Efficacy of membranous cultured periosteum for the treatment of patients with severe periodontitis: a proof-of-concept study.Nagoya J Med Sci.72: 59-70, 2010
Katagiri W, Yamada Y, Nakamura S, Ito K, Hara K, Hibi H, Ueda M.Regulation of the wnt signaling pathways during cell culture of human mesenchymal stem cells for efficient bone regeneration.Oral Sci Int.7: 37-46, 2010
Yamada Y, Nakamura S, Ito K, Sugito T, Yoshimi R, Nagasaka T, Ueda M.A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology.
The 2nd International Symposium Bone Conduction (2009.6.12 Sweden)Ueda M. Tissue engineering and osseointegration.
TERMIS World Congress 2009 (2009.8.31 Korea) Ueda M. Tissue engineering and anti-aging in dentistry
FDI (2009.9.3 Singapore) Ueda M. The future possibilities of teeth pulp stem cell for tissue engineering therapy.
BIOKOREA2009 (2009.9.17 Korea) Ueda M. Recent advances of tissue engineering in dentistry.
18th Annual Scientific Meeting of European Association for Osseointegration (2009.10.2-3 Monaco)Ueda M. Tissue engineering and implant.
AOI-ROCʼs annual Symposium (2009.10.11 Taipei, Taiwan) Ueda M. Tissue engineering and regenerative medicine.
Lecture in Kaohsiung Medical University (2009.12.13 Taiwan) Ueda M. Tissue engineering and implant.
1949年商家の次男として大阪府で生まれ、のどかな環境のなかで平凡な少年時代を送る。1963年〈中学2年〉偶然聞いたビートルズに衝撃を受けて以来、その音楽に魅了され芸術の世界に目覚める。高校入学を機に、さらにビートルズに傾倒し彼らの歌詞を通して言葉の美しさを認識する。そのころ世間は大学紛争の嵐の中にあり京都大学に入学するも、ストライキでキャンパスは閉鎖、やむなく近隣の芸術大学に通いはじめる。授業のないときには下宿先に引きこもり小説を読みふける日々を送る。上田は「青年期のビートルズ体験と芸大の空気は、自分の研究手法に影響をあたえた」と語っている。
Tissue Eng.10: 873-80, 2004
Yamada Y, Ueda M, Naiki T, Takahashi M, Hata K, Nagasaka T.Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone regeneration.Tissue Eng. 10: 955-64, 2004
(2005年〜)
Honda MJ, Sumita Y, Kagami H, Ueda M.Histological and immunohistochemical studies of tissue engineered odontogenesis. Arch Histol Cytol. 68: 89-101, 2005
Ohya M, Yamada Y, Ozawa R, Ito K, Takahashi M, Ueda M.Sinus floor elevation applied tissue-engineered bone. Comparative study between mesenchymal stem cells/platelet-rich plasma (PRP) and autogenous bone with PRP complexes in rabbits.Clin Oral Implants Res. 16: 622-9, 2005
上田 実(うえだ みのる、1949年5月30日 - )は、日本の歯科医師、再生医学者、顎顔面外科医、博士(医学)(名古屋大学)。
株式会社U-Factor取締役。株式会社再生医学研究所(SAISEIKEN)代表取締役会長。名古屋大学医学部教授、東京大学医科学研究所教授を歴任した。
皮膚、骨の再生医療の研究者として知られ、世界で初めて幹細胞の分泌するサイトカインが組織再生の主役であることを発見、従来の定説を覆した。さらにそれを含有する幹細胞培養上清を用いて、皮膚、骨の臨床応用に成功し、日本学術会議会長賞、日本再生医療学会ジョンソン&ジョンソン賞を受賞している。
再生医療の黎明期から再生医学の研究にたずさわり、研究論文数は600以上にのぼる。なかでも実際に人に応用した臨床症例数は、100例をこえ国際的にみても他の研究機関を圧倒している。また文部科学省や科学技術振興機構、AMEDなどの再生医療プロジェクトや委員会でも手腕を見せた。
欧米、アジアの大学との交流も深く、ベルゲン大学(ノルウェー)、ワシントン大学(アメリカ)などの客員教授を務めた。
再生研究の産業化にも積極的に取り組み、日本で初めての再生医療ベンチャーであるジャパン・テイッシュ・エンジニアリング社(JTEC社)の創設にも関わった。