プラコグロビン
PMC 2199929. PMID 7542250. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2199929/.
“The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers”. Proceedings of the National Academy of Sciences of the United States of America 92 (14): 6384–8. (Jul 1995). Bibcode: 1995PNAS...92.6384A. doi:10.1073/pnas.92.14.6384. PMC 41522. PMID 7604000. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC41522/.
“Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin”. The Journal of Biological Chemistry 270 (34): 20201–6. (Aug 1995). doi:10.1074/jbc.270.34.20201. PMID 7650039.
ヒトのプラコグロビンは745アミノ酸からなり、81.7 kDaである。JUP遺伝子は13個のエクソンを持ち、17q21に位置する17kbの長さの遺伝子である。プラコグロビンはカテニンファミリーのメンバーであり、アルマジロリピートと呼ばれる明確な反復配列モチーフを持つ。プラコグロビンはβ-カテニンと高度に類似しており、どちらも12個のアルマジロリピートと構造未知のN末端、C末端の球状ドメインを持つ。
“Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin”. The Journal of Cell Biology 118 (3): 671–9. (Aug 1992). doi:10.1083/jcb.118.3.671. PMC 2289540. PMID 1639850. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289540/.
“Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)”. Genomics 10 (3): 640–5. (Jul 1991). doi:10.1016/0888-7543(91)90446-L. PMID 1889810.
“Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia”. The Journal of Cell Biology 130 (2): 461–71. (Jul 1995). doi:10.1083/jcb.130.2.461.
Proceedings of the National Academy of Sciences of the United States of America 91 (23): 10790–4. (Nov 1994). Bibcode: 1994PNAS...9110790T. doi:10.1073/pnas.91.23.10790. PMC 45111. PMID 7971964. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45111/.
“Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation”. Biochemical and Biophysical Research Communications 203 (1): 519–22. (Aug 1994). doi:10.1006/bbrc.1994.2213. PMID 8074697.
“Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly”. The Journal of Cell Biology 125 (6): 1327–40. (Jun 1994). doi:10.1083/jcb.125.6.1327.