トポイソメラーゼ阻害薬
“Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance”. Cancer Res. 67 (21): 10397–405. (Nov 2007). doi:10.1158/0008-5472.can-07-0938. PMID 17974983.
“Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity”. Mol. Pharmacol. 70 (3): 1109–1120. (2006). doi:10.1124/mol.106.024372. PMID 16798938.
“Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison”. Mol. Pharmacol. 67 (2): 523–30.
(Feb 2005). doi:10.1124/mol.104.003889. PMID 15531731.
“Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.”. Cancer Res. 63 (21): 7428–35. (Nov 2003). PMID 14612542.
“Activity of indenoisoquinolines against African trypanosomes”. Antimicrob. Agents Chemother. 53 (1): 123–8. (Jan 2009). doi:10.1128/aac.00650-07. PMC 2612167. PMID 18824603. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612167/.
“Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast”. Molecular Cell 30 (6): 790–802. (Jun 2008). doi:10.