董培新
Additionally, we detected significantly higher levels of HSP90 in CC tissues compared with normal tissues, and high expression of HSP90 predicted a poorer prognosis. We further identified NEAT1 as a significantly upregulated lncRNA in CC tissues and high expression of NEAT1 was associated with worse survival in CC patients. NEAT1 directly repressed miR-361 expression and played an oncogenic role in CC cell invasion and sphere formation. Conclusions: These results demonstrated that miR-361 directly targets HSP90 to inhibit the invasion and EMT features, and NEAT1 functions as an oncogenic lncRNA that suppresses miR-361 expression and induces EMT and sphere formation in CC cells, thus providing critical insights into the molecular pathways operating in this malignancy.
癌転移
婦人科癌; endometrial carcinoma; cervical cancer; ovarian cancer
microRNA
EMT: epithelial to mesenchymal transition (EMT)
Twist1 gene, a critical EMT inducer in endometrial cancer
en:Cervical_cancer cervical cancer
p53: TP53, tumor suppressor in human tumors
endometrial cancer
ovarian cancer
miR-194 is a tumor suppressor in endometrial cancer
Prognostic significance of miR-194 in endometrial cancer
miR-130b in endometrial cancer
miR-101 is key tumor suppressor in both type I and type II endometrial cancer
IQGAP1 is novel oncogene in endometrial cancer and ovarian cancer
miR-106b acts as tumor suppressor in aggressive in endometrial cancer
KLF17 gene induces EMT in endometrial cancer