肝毒性
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アセトアミノフェン、四塩化炭素
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肝障害により胆汁の流れが悪くなり、痒みや黄疸が主な症状として出現する。組織学的には、炎症を示す場合(胆汁性肝炎)と、示さない場合がある。まれに、小胆管の進行性破壊により、原発性胆汁性肝硬変に類似した特徴を示すことがある(胆管消失症候群(英語版))。