ノギテカン
骨髄抑制:白血球数減少(99.2%)、好中球数減少(97.8%)、赤血球数減少(92.2%)、ヘモグロビン減少(92.3%)、血小板数減少(85.4%)、発熱性好中球減少症(12.8%)、汎血球減少症(1.3%)など
消化管出血(下血も含む:1.2%)
間質性肺炎(2.5%)
肺塞栓症、深部静脈血栓症(頻度不明)
PMC 3257422. PMID 22190039. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257422/.
↑ (Aditi and Williams)
↑ “DNA topoisomerases and their poisoning by anticancer and antibacterial drugs”. Chemistry & Biology 17 (5): 421–33. (May 2010). doi:10.1016/j.chembiol.2010.04.012. PMC 7316379. PMID 20534341. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316379/.
1 2 3 Cordell, Geoffrey, ed (2003). The Alkaloids: Chemistry and Biology. California: Academic Press. pp. 1–50. ISBN 978-0080521497. https://archive.org/details/isbn_0124695604
1 2 3 4 “Topoisomerase I inhibitors: camptothecins and beyond”. Nature Reviews.