グリシンtRNAリガーゼ
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
Del Bo R, Locatelli F, Corti S, et al. (2006). “Coexistence of CMT-2D and distal SMA-V phenotypes in an Italian family with a GARS gene mutation.”. Neurology 66 (5): 752–4. doi:10.1212/01.wnl.0000201275.18875.ac. PMID 16534118.
James PA, Cader MZ, Muntoni F, et al. (2006). “Severe childhood SMA and axonal CMT due to anticodon binding domain mutations in the GARS gene.”. Neurology 67 (9): 1710–2. doi:10.1212/01.wnl.0000242619.52335.bc. PMID 17101916.
Xie W, Schimmel P, Yang XL (2006). “Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease.”. Acta Crystallogr. Sect. F Struct.
グリシンtRNAリガーゼは、tRNAを関連するアミノ酸と結合させるアミノアシルtRNA合成酵素の一種である。酵素はα二量体を形成し、II型のtRNA合成酵素である。