HIPK2
“Viruses as hijackers of PML nuclear bodies”. Archivum Immunologiae et Therapiae Experimentalis 51 (5): 295–300. (2004). PMID 14626429.
“HIPK2: a versatile switchboard regulating the transcription machinery and cell death”. Cell Cycle 6 (2): 139–43. (January 2007). doi:10.4161/cc.6.2.3788. PMID 17245128.
“Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors”. The Journal of Biological Chemistry 273 (40): 25875–9. (October 1998). doi:10.1074/jbc.273.40.25875. PMID 9748262.
“Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1”.
Nature Cell Biology 4 (1): 11–9. (January 2002). doi:10.1038/ncb714. PMID 11780126.
“The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues”. Biochemical and Biophysical Research Communications 290 (3): 942–7. (January 2002). doi:10.1006/bbrc.2001.6310. PMID 11798164.
“Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo”. The Journal of Biological Chemistry 277 (35): 32020–8. (August 2002). doi:10.1074/jbc.M200153200. PMID 11925430.
“HIPK2 associates with RanBPM”.
BMC Molecular Biology 2: 8. (2003). doi:10.1186/1471-2199-2-8. PMC 48146. PMID 11532197. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48146/.
“High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth”. Oncogene 20 (43): 6132–41. (September 2001). doi:10.1038/sj.onc.1204635. PMID 11593421.
“Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2”. Nature Cell Biology 4 (1): 1–10. (January 2002). doi:10.1038/ncb715. PMID 11740489.
“Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis”.
HIPK2(homeodomain-interacting protein kinase 2)は、ヒトではHIPK2遺伝子にコードされる酵素である。HIPK2はセリン/スレオニンキナーゼに分類され、ホメオドメイン型転写因子と相互作用する。DYRKキナーゼと呼ばれるプロテインキナーゼのファミリーに属する。このファミリー内では、HIPK2はHIPK1(英語版)やHIPK3(英語版)とともにHIPK(homeodomain-interacting protein kinase)グループに属する。HIPK2はさまざまな生物種に広く存在し、その遺伝子発現やアポトーシスにおける機能はいくつかの異なる機構によって調節されている。