コンデンシン
“Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei”. PLoS Genet 14 (7): e1007393. doi: 10.1371/journal.pgen.1007393. PMID 30001329.
↑ Ono T, Yamashita D, Hirano T (2013). “Condensin II initiates sister chromatid resolution during S phase”. J. Cell Biol. 200 (4): 429-441. PMID 23401001.
↑ Dekker B, Dekker J (2022). “Regulation of the mitotic chromosome folding machines”. Biochem J 479 (20): 2153-2173. PMID 36268993.
1 2 Bazile F, St-Pierre J, D'Amours D (2010). “Three-step model for condensin activation during mitotic chromosome condensation”. Cell Cycle 9 (16): 3243-3255. PMID 20703077.
↑ Robellet X, Thattikota Y, Wang F, Wee TL, Pascariu M, Shankar S, Bonneil É, Brown CM, D'Amours D (2015).
↑ Hoencamp C, Dudchenko O, Elbatsh AMO, Brahmachari S, Raaijmakers JA, van Schaik T, Sedeño Cacciatore Á, Contessoto VG, van Heesbeen RGHP, van den Broek B, Mhaskar AN, Teunissen H, St Hilaire BG, Weisz D, Omer AD, Pham M, Colaric Z, Yang Z, Rao SSP, Mitra N, Lui C, Yao W, Khan R, Moroz LL, Kohn A, St Leger J, Mena A, Holcroft K, Gambetta MC, Lim F, Farley E, Stein N, Haddad A, Chauss D, Mutlu AS, Wang MC, Young ND, Hildebrandt E, Cheng HH, Knight CJ, Burnham TLU, Hovel KA, Beel AJ, Mattei PJ, Kornberg RD, Warren WC, Cary G, Gómez-Skarmeta JL, Hinman V, Lindblad-Toh K, Di Palma F, Maeshima K, Multani AS, Pathak S, Nel-Themaat L, Behringer RR, Kaur P, Medema RH, van Steensel B, de Wit E, Onuchic JN, Di Pierro M, Lieberman Aiden E, Rowland BD (2021). “3D genomics across the tree of life reveals condensin II as a determinant of architecture type”. Science 372 (6545): 984-989. PMID 34045355.
コンデンシンに類似したタンパク質複合体は原核生物にも存在し、やはり染色体(核様体)の構築と分離に関与している。それらは大きくSMC-ScpABとMukBEFという2つの複合体に分類することができる。原核生物型コンデンシンは、真核生物型に比べて、より単純なつくりをしている。例えば、真核生物型のSMCサブユニットがヘテロ2量体であるのに対し、原核生物型のSMCサブユニット(あるいはMukBサブユニット)はホモ2量体である。制御サブユニットのうち、ScpAとMukFはkleisinファミリーに分類されるため、SMC-kleisin3量体の基本構造は真核細胞と原核細胞の間で保存されているといってよい。一方、ScpBとMukEはkiteファミリーに分類され、真核細胞型のHEATリピートサブユニットとは大きく異なる。
“Cohesins and condensins orchestrate the 4D dynamics of yeast chromosomes during the cell cycle”. EMBO J 36 (18): 2684-2697. PMID 28729434.
↑ Kakui Y, Rabinowitz A, Barry DJ, Uhlmann F (2017). “Condensin-mediated remodeling of the mitotic chromatin landscape in fission yeast”. Nat Genet 49 (10): 1553-1557. PMID 28825727.
↑ Tanizawa H, Kim KD, Iwasaki O, Noma KI (2017). “Architectural alterations of the fission yeast genome during the cell cycle”. Nat Struct Mol Biol (11): 965-976. PMID 28991264.
↑ Gibcus JH, Samejima K, Goloborodko A, Samejima I, Naumova N, Nuebler J, Kanemaki MT, Xie L, Paulson JR, Earnshaw WC, Mirny LA, Dekker J (2018). “A pathway for mitotic chromosome formation”.
“Plasmodium condensin core subunits SMC2/SMC4 mediate atypical mitosis and are essential for parasite proliferation and transmission”. Cell Rep. 30 (6): 1883-1897.e6. PMID 32049018.
1 2 Hartl TA, Smith HF, Bosco G (2008). “Chromosome alignment and transvection are antagonized by condensin II”. Science 322 (5906): 1384-1387. PMID 19039137.
↑ Bauer CR, Hartl TA, Bosco G (2012). “Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes”. PLoS Genet 8 (8): e1002873. PMID 22956908.
↑ Rosin LF, Nguyen SC, Joyce EF (2018).