プロテインキナーゼR
プロテインキナーゼR (protein kinase R, PKR) は、ヒトではEIF2AK2遺伝子にコードされている酵素(キナーゼ)で、ウイルス感染からの保護を行う。protein kinase RNA-activated、interferon-induced double-stranded RNA-activated protein kinase、eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) などの別名でも知られる。
Barber GN, Wambach M, Wong ML, Dever TE, Hinnebusch AG, Katze MG (May 1993). “Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase”. Proceedings of the National Academy of Sciences of the United States of America 90 (10): 4621–5. doi:10.1073/pnas.90.10.4621. PMC 46564. PMID 8099444. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46564/.
Chen ZJ, Parent L, Maniatis T (March 1996). “Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity”. Cell 84 (6): 853–62. doi:10.1016/S0092-8674(00)81064-8. PMID 8601309.
Kuhen KL, Shen X, Carlisle ER, Richardson AL, Weier HU, Tanaka H, Samuel CE (August 1996). “Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog”.