yz2022/T2P-DownstreamNLP huggingface dataset:
Gene

Two chains of DNA twist around each other to form a DNA double helix with the phosphate-sugar backbone spiralling around the outside, and the bases pointing inwards with adenine base pairing to thymine and guanine to cytosine. The specificity of base pairing occurs because adenine and thymine align form two hydrogen bonds, whereas cytosine and guanine form three hydrogen bonds. The two strands in a double helix must therefore be complementary, with their sequence of bases matching such that the adenines of one strand are paired with the thymines of the other strand, and so on.:4.1

Question: Due to the cause of the specificity of base pairing, what must be true of the two strands in a double helix?
Answer: The two strands in a double helix must therefore be complementary
Gene

The existence of discrete inheritable units was first suggested by Gregor Mendel (1822–1884). From 1857 to 1864, he studied inheritance patterns in 8000 common edible pea plants, tracking distinct traits from parent to offspring. He described these mathematically as 2n combinations where n is the number of differing characteristics in the original peas. Although he did not use the term gene, he explained his results in terms of discrete inherited units that give rise to observable physical characteristics. This description prefigured the distinction between genotype (the genetic material of an organism) and phenotype (the visible traits of that organism). Mendel was also the first to demonstrate independent assortment, the distinction between dominant and recessive traits, the distinction between a heterozygote and homozygote, and the phenomenon of discontinuous inheritance.

Question: If a distinct trait in edible pea plants is mathematically described as a 2n combination, what does n represent? 
Answer: n is the number of differing characteristics in the original peas
Gene

Genes are regulated so that they are expressed only when the product is needed, since expression draws on limited resources.:7 A cell regulates its gene expression depending on its external environment (e.g. available nutrients, temperature and other stresses), its internal environment (e.g. cell division cycle, metabolism, infection status), and its specific role if in a multicellular organism. Gene expression can be regulated at any step: from transcriptional initiation, to RNA processing, to post-translational modification of the protein. The regulation of lactose metabolism genes in E. coli (lac operon) was the first such mechanism to be described in 1961.

Question: What are examples of a cell's internal environment?
Answer: cell division cycle, metabolism, infection status

Question: What example of post-translational modification of a protein was first described in 1961?
Answer: The regulation of lactose metabolism genes in E. coli

Question: At which step can gene expression be regulated?
Answer: at any step
Gene

The vast majority of living organisms encode their genes in long strands of DNA (deoxyribonucleic acid). DNA consists of a chain made from four types of nucleotide subunits, each composed of: a five-carbon sugar (2'-deoxyribose), a phosphate group, and one of the four bases adenine, cytosine, guanine, and thymine.:2.1

Question: What do the vast majority of living organisms encode their genes in?
Answer: long strands of DNA (deoxyribonucleic acid)
Alps

During the post-World War I period ski-lifts were built in Swiss and Austrian towns to accommodate winter visitors, but summer tourism continued to be important; by the mid-20th century the popularity of downhill skiing increased greatly as it became more accessible and in the 1970s several new villages were built in France devoted almost exclusively to skiing, such as Les Menuires. Until this point Austria and Switzerland had been the traditional and more popular destinations for winter sports, but by the end of the 20th century and into the early 21st century, France, Italy and the Tyrol began to see increases in winter visitors. From 1980 to the present, ski-lifts have been modernized and snow-making machines installed at many resorts, leading to concerns regarding the loss of traditional Alpine culture and questions regarding sustainable development as the winter ski industry continues to develop quickly and the number of summer tourists decline.

Question: When were ski-lifts built in Swiss and Austrian towns?
Answer: post-World War I
Gene

Genes are regulated so that they are expressed only when the product is needed, since expression draws on limited resources.:7 A cell regulates its gene expression depending on its external environment (e.g. available nutrients, temperature and other stresses), its internal environment (e.g. cell division cycle, metabolism, infection status), and its specific role if in a multicellular organism. Gene expression can be regulated at any step: from transcriptional initiation, to RNA processing, to post-translational modification of the protein. The regulation of lactose metabolism genes in E. coli (lac operon) was the first such mechanism to be described in 1961.

Question: What are examples of a cell's external environment?
Answer: available nutrients, temperature and other stresses
Alps

Roofs are traditionally constructed from Alpine rocks such as pieces of schist, gneiss or slate. Such chalets are typically found in the higher parts of the valleys, as in the Maurienne valley in Savoy, where the amount of snow during the cold months is important. The inclination of the roof cannot exceed 40%, allowing the snow to stay on top, thereby functioning as insulation from the cold. In the lower areas where the forests are widespread, wooden tiles are traditionally used. Commonly made of Norway spruce, they are called "tavaillon". The Alpine regions are multicultural and linguistically diverse. Dialects are common, and vary from valley to valley and region to region. In the Slavic Alps alone 19 dialects have been identified. Some of the French dialects spoken in the French, Swiss and Italian alps of Aosta Valley derive from Arpitan, while the southern part of the western range is related to Old Provençal; the German dialects derive from Germanic tribal languages. Romansh, spoken by two percent of the population in southeast Switzerland, is an ancient Rhaeto-Romanic language derived from Latin, remnants of ancient Celtic languages and perhaps Etruscan.

Question: What are roofs traditionally constructed from? 
Answer: Alpine rocks
Gene

Genes are regulated so that they are expressed only when the product is needed, since expression draws on limited resources.:7 A cell regulates its gene expression depending on its external environment (e.g. available nutrients, temperature and other stresses), its internal environment (e.g. cell division cycle, metabolism, infection status), and its specific role if in a multicellular organism. Gene expression can be regulated at any step: from transcriptional initiation, to RNA processing, to post-translational modification of the protein. The regulation of lactose metabolism genes in E. coli (lac operon) was the first such mechanism to be described in 1961.

Question: When are genes expressed?
Answer: only when the product is needed
Gene

The genome size, and the number of genes it encodes varies widely between organisms. The smallest genomes occur in viruses (which can have as few as 2 protein-coding genes), and viroids (which act as a single non-coding RNA gene). Conversely, plants can have extremely large genomes, with rice containing >46,000 protein-coding genes. The total number of protein-coding genes (the Earth's proteome) is estimated to be 5 million sequences.

Question: What is the smallest number of protein coding genes that a virus can have?
Answer: 2
Alps

Roofs are traditionally constructed from Alpine rocks such as pieces of schist, gneiss or slate. Such chalets are typically found in the higher parts of the valleys, as in the Maurienne valley in Savoy, where the amount of snow during the cold months is important. The inclination of the roof cannot exceed 40%, allowing the snow to stay on top, thereby functioning as insulation from the cold. In the lower areas where the forests are widespread, wooden tiles are traditionally used. Commonly made of Norway spruce, they are called "tavaillon". The Alpine regions are multicultural and linguistically diverse. Dialects are common, and vary from valley to valley and region to region. In the Slavic Alps alone 19 dialects have been identified. Some of the French dialects spoken in the French, Swiss and Italian alps of Aosta Valley derive from Arpitan, while the southern part of the western range is related to Old Provençal; the German dialects derive from Germanic tribal languages. Romansh, spoken by two percent of the population in southeast Switzerland, is an ancient Rhaeto-Romanic language derived from Latin, remnants of ancient Celtic languages and perhaps Etruscan.

Question: How many dialects have been identified in the Slavic Alps?
Answer: 19
Gene

Prior to Mendel's work, the dominant theory of heredity was one of blending inheritance, which suggested that each parent contributed fluids to the fertilisation process and that the traits of the parents blended and mixed to produce the offspring. Charles Darwin developed a theory of inheritance he termed pangenesis, which used the term gemmule to describe hypothetical particles that would mix during reproduction. Although Mendel's work was largely unrecognized after its first publication in 1866, it was 'rediscovered' in 1900 by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak, who claimed to have reached similar conclusions in their own research.

Question: What was the dominant theory of heredity prior to Mendel's work?
Answer: one of blending inheritance
Gene

The genome size, and the number of genes it encodes varies widely between organisms. The smallest genomes occur in viruses (which can have as few as 2 protein-coding genes), and viroids (which act as a single non-coding RNA gene). Conversely, plants can have extremely large genomes, with rice containing >46,000 protein-coding genes. The total number of protein-coding genes (the Earth's proteome) is estimated to be 5 million sequences.

Question: In which type of organism do the smallest genomes occur?
Answer: viruses

Question: What is one characteristic that varies widely between organisms?
Answer: genome size
Gene

Prior to Mendel's work, the dominant theory of heredity was one of blending inheritance, which suggested that each parent contributed fluids to the fertilisation process and that the traits of the parents blended and mixed to produce the offspring. Charles Darwin developed a theory of inheritance he termed pangenesis, which used the term gemmule to describe hypothetical particles that would mix during reproduction. Although Mendel's work was largely unrecognized after its first publication in 1866, it was 'rediscovered' in 1900 by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak, who claimed to have reached similar conclusions in their own research.

Question: What does the term gemmule describe?
Answer: hypothetical particles that would mix during reproduction
Gene

The genome size, and the number of genes it encodes varies widely between organisms. The smallest genomes occur in viruses (which can have as few as 2 protein-coding genes), and viroids (which act as a single non-coding RNA gene). Conversely, plants can have extremely large genomes, with rice containing >46,000 protein-coding genes. The total number of protein-coding genes (the Earth's proteome) is estimated to be 5 million sequences.

Question: Which organism acts as a single non coding RNA gene?
Answer: viroids

Question: What is the estimate for the total number of protein coding genes on Earth?
Answer: 5 million
Gene

Although the number of base-pairs of DNA in the human genome has been known since the 1960s, the estimated number of genes has changed over time as definitions of genes, and methods of detecting them have been refined. Initial theoretical predictions of the number of human genes were as high as 2,000,000. Early experimental measures indicated there to be 50,000–100,000 transcribed genes (expressed sequence tags). Subsequently, the sequencing in the Human Genome Project indicated that many of these transcripts were alternative variants of the same genes, and the total number of protein-coding genes was revised down to ~20,000 with 13 genes encoded on the mitochondrial genome. Of the human genome, only 1–2% consists of protein-coding genes, with the remainder being 'noncoding' DNA such as introns, retrotransposons, and noncoding RNAs.

Question: Since when has the number of base pairs of DNA in the human genome been known?
Answer: the 1960s

Question: What was the highest initial theoretical prediction of the number of human genes?
Answer: 2,000,000
Alps

During the post-World War I period ski-lifts were built in Swiss and Austrian towns to accommodate winter visitors, but summer tourism continued to be important; by the mid-20th century the popularity of downhill skiing increased greatly as it became more accessible and in the 1970s several new villages were built in France devoted almost exclusively to skiing, such as Les Menuires. Until this point Austria and Switzerland had been the traditional and more popular destinations for winter sports, but by the end of the 20th century and into the early 21st century, France, Italy and the Tyrol began to see increases in winter visitors. From 1980 to the present, ski-lifts have been modernized and snow-making machines installed at many resorts, leading to concerns regarding the loss of traditional Alpine culture and questions regarding sustainable development as the winter ski industry continues to develop quickly and the number of summer tourists decline.

Question: Where is Les Menuires located? 
Answer: France
Gene

Although the number of base-pairs of DNA in the human genome has been known since the 1960s, the estimated number of genes has changed over time as definitions of genes, and methods of detecting them have been refined. Initial theoretical predictions of the number of human genes were as high as 2,000,000. Early experimental measures indicated there to be 50,000–100,000 transcribed genes (expressed sequence tags). Subsequently, the sequencing in the Human Genome Project indicated that many of these transcripts were alternative variants of the same genes, and the total number of protein-coding genes was revised down to ~20,000 with 13 genes encoded on the mitochondrial genome. Of the human genome, only 1–2% consists of protein-coding genes, with the remainder being 'noncoding' DNA such as introns, retrotransposons, and noncoding RNAs.

Question: What sort of variants did the Human Genome Project indicate that many of the measured transcripts were?
Answer: alternative variants

Question: What percentage of the human genome consists of protein coding genes?
Answer: 1–2%

Question: After the Human Genome Project, how many genes were encoded on the mitochondrial genome?
Answer: 13
Alps

During the post-World War I period ski-lifts were built in Swiss and Austrian towns to accommodate winter visitors, but summer tourism continued to be important; by the mid-20th century the popularity of downhill skiing increased greatly as it became more accessible and in the 1970s several new villages were built in France devoted almost exclusively to skiing, such as Les Menuires. Until this point Austria and Switzerland had been the traditional and more popular destinations for winter sports, but by the end of the 20th century and into the early 21st century, France, Italy and the Tyrol began to see increases in winter visitors. From 1980 to the present, ski-lifts have been modernized and snow-making machines installed at many resorts, leading to concerns regarding the loss of traditional Alpine culture and questions regarding sustainable development as the winter ski industry continues to develop quickly and the number of summer tourists decline.

Question: When were several new villages built in France almost exclusively for skiing?
Answer: the 1970s
Alps

Roofs are traditionally constructed from Alpine rocks such as pieces of schist, gneiss or slate. Such chalets are typically found in the higher parts of the valleys, as in the Maurienne valley in Savoy, where the amount of snow during the cold months is important. The inclination of the roof cannot exceed 40%, allowing the snow to stay on top, thereby functioning as insulation from the cold. In the lower areas where the forests are widespread, wooden tiles are traditionally used. Commonly made of Norway spruce, they are called "tavaillon". The Alpine regions are multicultural and linguistically diverse. Dialects are common, and vary from valley to valley and region to region. In the Slavic Alps alone 19 dialects have been identified. Some of the French dialects spoken in the French, Swiss and Italian alps of Aosta Valley derive from Arpitan, while the southern part of the western range is related to Old Provençal; the German dialects derive from Germanic tribal languages. Romansh, spoken by two percent of the population in southeast Switzerland, is an ancient Rhaeto-Romanic language derived from Latin, remnants of ancient Celtic languages and perhaps Etruscan.

Question: What language is spoken by two percent of the population in southeast Switzerland? 
Answer: Romansh
Gene

The most common source of new genes in eukaryotic lineages is gene duplication, which creates copy number variation of an existing gene in the genome. The resulting genes (paralogs) may then diverge in sequence and in function. Sets of genes formed in this way comprise a gene family. Gene duplications and losses within a family are common and represent a major source of evolutionary biodiversity. Sometimes, gene duplication may result in a nonfunctional copy of a gene, or a functional copy may be subject to mutations that result in loss of function; such nonfunctional genes are called pseudogenes.:7.6

Question: What are functional copies of a gene which have a loss of function due to mutation called?
Answer: pseudogenes
Gene

Prior to Mendel's work, the dominant theory of heredity was one of blending inheritance, which suggested that each parent contributed fluids to the fertilisation process and that the traits of the parents blended and mixed to produce the offspring. Charles Darwin developed a theory of inheritance he termed pangenesis, which used the term gemmule to describe hypothetical particles that would mix during reproduction. Although Mendel's work was largely unrecognized after its first publication in 1866, it was 'rediscovered' in 1900 by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak, who claimed to have reached similar conclusions in their own research.

Question: Who developed the theory of inheritance known as pangenesis?
Answer: Charles Darwin

Question: Who are the three scientists that claimed to have reached conclusions similar to Mendel's?
Answer: Hugo de Vries, Carl Correns, and Erich von Tschermak

Question: What year was Mendel's work first published?
Answer: 1866
Guinea-Bissau

Only 14% of the population speaks Portuguese, established as the official language in the colonial period. Almost half the population (44%) speaks Crioulo, a Portuguese-based creole language, and the remainder speak a variety of native African languages. The main religions are African traditional religions and Islam; there is a Christian (mostly Roman Catholic) minority. The country's per-capita gross domestic product is one of the lowest in the world.

Question: What percentage of the population speaks Portuguese?
Answer: 14%

Question: What percentage of the population speaks Crioulo?
Answer: 44%

Question: What is the minority religion?
Answer: Christian (mostly Roman Catholic)

Question: What is their gross domestic product status?
Answer: one of the lowest in the world

Question: What are the two main religions?
Answer: African traditional religions and Islam
Gene

De novo or "orphan" genes, whose sequence shows no similarity to existing genes, are extremely rare. Estimates of the number of de novo genes in the human genome range from 18 to 60. Such genes are typically shorter and simpler in structure than most eukaryotic genes, with few if any introns. Two primary sources of orphan protein-coding genes are gene duplication followed by extremely rapid sequence change, such that the original relationship is undetectable by sequence comparisons, and formation through mutation of "cryptic" transcription start sites that introduce a new open reading frame in a region of the genome that did not previously code for a protein.

Question: What is one primary source of orphan protein-coding genes?
Answer: gene duplication followed by extremely rapid sequence change
Alps

In the first half of the 20th century the Olympic Winter Games were held three times in Alpine venues: the 1924 Winter Olympics in Chamonix, France; the 1928 Winter Olympics in St. Moritz, Switzerland; and the 1936 Winter Olympics in Garmisch-Partenkirchen, Germany. During World War II the winter games were canceled but after that time the Winter Games have been held in St. Moritz (1948), Cortina d'Ampezzo (1956), Innsbruck, Austria (1964 and 1976), Grenoble, France, (1968), Albertville, France, (1992), and Torino (2006). In 1930 the Lauberhorn Rennen (Lauberhorn Race), was run for the first time on the Lauberhorn above Wengen; the equally demanding Hahnenkamm was first run in the same year in Kitzbühl, Austria. Both races continue to be held each January on successive weekends. The Lauberhorn is the more strenuous downhill race at 4.5 km (2.8 mi) and poses danger to racers who reach 130 km/h (81 mph) within seconds of leaving the start gate.

Question: Where were the Winter Olympics held in 1924?
Answer: Chamonix, France

Question: Where were the Winter Olympics held in 1928?
Answer: St. Moritz, Switzerland
Gene

Essential genes are the set of genes thought to be critical for an organism's survival. This definition assumes the abundant availability of all relevant nutrients and the absence of environmental stress. Only a small portion of an organism's genes are essential. In bacteria, an estimated 250–400 genes are essential for Escherichia coli and Bacillus subtilis, which is less than 10% of their genes. Half of these genes are orthologs in both organisms and are largely involved in protein synthesis. In the budding yeast Saccharomyces cerevisiae the number of essential genes is slightly higher, at 1000 genes (~20% of their genes). Although the number is more difficult to measure in higher eukaryotes, mice and humans are estimated to have around 2000 essential genes (~10% of their genes).

Question: What does the definition of essential genes assume an absence of?
Answer: environmental stress

Question: How many genes are essential for Escherichia coli?
Answer: 250–400

Question: What are the set of genes which are thought to be crucial for the survival of an organism?
Answer: Essential genes

Question: How many essential genes does Saccharomyces cerevisiae have?
Answer: 1000 genes

Question: What fraction of Escherichia coli's essential genes are orthologs?
Answer: Half