caption: the obesity disease infector
exif: {"Image DocumentName": "Obesity-Associated Adipose Tissue Inflammation", "Image ImageDescription": "With increased obesity adipose tissue macrophages are polarized from anti-inflammatory macrophages (M2) to predominance of inflammatory type macrophages (M1). Both the number of M1 macrophages and M1:M2 ratio are associated with systemic inflammation and induction of insulin resistance. These results represent findings in various rodent models. There is some concern that this may not completely reflect what is seen in humans. Recent data suggest that there may be a distinct difference between rodent and human macrophage infiltration in adipose tissue. This difference was noted not only in number, but also polarity. In addition, mouse obesity models often represent acute changes in weight (weeks on a specifically enriched HFD) rather than chronic changes associated with a sedentary lifestyle and increased but varied caloric intake. These potential differences highlight the need for a good intermediate model of obesity. Ouchi et al Nature Reviews immunology. Feb M2 > M1. M1 > M2. INFLAMMATION.", "Image XResolution": "37", "Image YResolution": "37", "Image ResolutionUnit": "Pixels/Centimeter", "Image Software": "SlidePlayer", "Image YCbCrPositioning": "Centered"}