yusuke1997/dblp-id-title huggingface dataset:
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity
3D QSAR Investigations on Antimalarial Naphthylisoquinoline Alkaloids by Comparative Molecular Similarity Indices Analysis (CoMSIA), Based on Different Alignment Approaches
Mechanisms and Opportunities for Rational In Silico Design of Enzymes to Degrade Per- and Polyfluoroalkyl Substances (PFAS)
The PRINTS Database of Protein Fingerprints: A Novel Information Resource for Computational Molecular Biology
VMD Store-A VMD Plugin to Browse, Discover, and Install VMD Extensions
Coding Chemical Trees with the Centered N-tuple Code
The Future of Molecular Studies through the Lens of Large Language Models
FibrilGen: A Python Package for Atomistic Modeling of Peptide β-Sheet Nanostructures
Reparametrization of the COSMO Solvent Model for Semiempirical Methods PM6 and PM7
p K a Prediction from "Quantum Chemical Topology" Descriptors
Editorial on Machine Learning
Coding and Ordering Kekulé Structures
Structural Basis of Fullerene Derivatives as Novel Potent Inhibitors of Protein Tyrosine Phosphatase 1B: Insight into the Inhibitory Mechanism through Molecular Modeling Studies
Protein-Ligand Docking Using Hamiltonian Replica Exchange Simulations with Soft Core Potentials
Application of graph theoretical parameters in quantifying molecular similarity and structure-activity relationships
Computer storage and retrieval of generic chemical structures using structure attributes
A drug is born: its formation facets in pharmaceutical research and development
Accurate Classification of Homodimeric vs Other Homooligomeric Proteins Using a New Measure of Information Discrepancy
Correlation between Structure and Normal Boiling Points of Acyclic Carbonyl Compounds [J. Chem. Inf. Comput. Sci 39, 758-764 (1999)]
Predictive Modeling of NMR Chemical Shifts without Using Atomic-Level Annotations
Polymyxin Binding to the Bacterial Outer Membrane Reveals Cation Displacement and Increasing Membrane Curvature in Susceptible but Not in Resistant Lipopolysaccharide Chemotypes
Evolving Interpretable Structure-Activity Relationships. 1. Reduced Graph Queries
Predicting and Analyzing Nitrate Adsorption on High-Entropy Alloys Based on Pair Distribution Function Using a Hybrid Machine Learning Framework
Protein Structural Statistics with PSS
Searching Fragment Spaces with Feature Trees
iCYP-MFE: Identifying Human Cytochrome P450 Inhibitors Using Multitask Learning and Molecular Fingerprint-Embedded Encoding
Ensemble Geometric Deep Learning of Aqueous Solubility
Mechanistic Insights into the Allosteric Regulation of P53 Y220C by Small-Molecule Stabilizers
Cyclization Scaffolding for Improved Vaccine Immunogen Stability: Application to Tau Protein in Alzheimer's Disease
Abstracts and other information filters
Predictive Models for Human Cytochrome P450 3A7 Selective Inhibitors and Substrates
Computer storage and retrieval of generic chemical structures in patents. 14. Fragment generation from generic structures
Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1
SPREAD: A Fully Automated Toolkit for Single-Particle Cryogenic Electron Microscopy Data 3D Reconstruction with Image-Network-Aided Orientation Assignment
What is Wrong with Quantitative Structure-Property Relations Models Based on Three-Dimensional Descriptors?
The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions
Documentation and indexing of C4 compounds: pathways and pitfalls
Exploration and Comparison of the Geometrical and Physicochemical Properties of an αC Allosteric Pocket in the Structural Kinome
Construction of High-Quality Structure-Property-Activity Regressions: The Boiling Points of Sulfides
GARD: A Generally Applicable Replacement for RMSD
A Compact Form of the Adjacency Matrix
Improved Scaffold Hopping in Ligand-Based Virtual Screening Using Neural Representation Learning
Automatic identification of molecular similarity using reduced-graph representation of chemical structure
Version of Zones and Zigzag Structure in Icosahedral Fullerenes and Icosadeltahedra
Investigating Pharmacological Similarity by Charting Chemical Space
Modeling Robust QSAR 3: SOM-4D-QSAR with Iterative Variable Elimination IVE-PLS: Application to Steroid, Azo Dye, and Benzoic Acid Series
Ligand Prediction for Orphan Targets Using Support Vector Machines and Various Target-Ligand Kernels Is Dominated by Nearest Neighbor Effects
PolyDAT: A Generic Data Schema for Polymer Characterization
ESP: A Method To Predict Toxicity and Pharmacological Properties of Chemicals Using Multiple MCASE Databases
The Receptor-like Neural Network for Modeling Corticosteroid and Testosterone Binding Globulins
Predicting Thermodynamic Properties of Alkanes by High-Throughput Force Field Simulation and Machine Learning
Evaluation of a Published in Silico Model and Construction of a Novel Bayesian Model for Predicting Phospholipidosis Inducing Potential
Prediction of the Favorable Hydration Sites in a Protein Binding Pocket and Its Application to Scoring Function Formulation
Description of organic reactions based on imaginary transition structures. 2. Classification of one-string reactions having an even-membered cyclic reaction graph
Orismology (The Science of Defining Words) and the Geometrical Foundations of Chemistry. 2. Inherent Topology
Modeling crystal structures by numerical methods: a tool for practical structure analysis
Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2: A Molecular Dynamics Simulation Study
Three-Dimensional Pattern Recognition from Molecular Distance Minimization
Versatile Deep Learning Pipeline for Transferable Chemical Data Extraction
Comparison of Similarity Coefficients for Clustering and Compound Selection
Small-Molecule Adsorption Energy Predictions for High-Throughput Screening of Electrocatalysts
Fragment-Based Analysis of Ligand Dockings Improves Classification of Actives
Isomorphism, Automorphism Partitioning, and Canonical Labeling Can Be Solved in Polynomial-Time for Molecular Graphs
Inactive-to-Active Transition of Human Thymidine Kinase 1 Revealed by Molecular Dynamics Simulations
DR-Predictor: Incorporating Flexible Docking with Specialized Electronic Reactivity and Machine Learning Techniques to Predict CYP-Mediated Sites of Metabolism
Prediction of Human Intestinal Absorption of Drug Compounds from Molecular Structure
Mechanism of AGT-Mediated Repair of dG-dC Cross-Links in the Drug Resistance to Chloroethylnitrosoureas: Molecular Docking, MD Simulation, and ONIOM (QM/MM) Investigation
BNM-CDGNN: Batch Normalization Multilayer Perceptron Crystal Distance Graph Neural Network for Excellent-Performance Crystal Property Prediction
Discovery of α7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13
Perspectives on editorial operations of Chemical Abstracts Service
Fast Partial-Differential Synthesis of the Matching Polynomial of C72-100
Molecular Hypergraphs: The New Representation of Nonclassical Molecular Structures with Polycentric Delocalized Bonds
Homology Model-Based Virtual Screening for GPCR Ligands Using Docking and Target-Biased Scoring
A Novel Concept for the Search and Retrieval of the Derwent Markush Resource Database
iSIM-Sigma: Efficient Standard Deviation Calculation for Molecular Similarity
Reconstruction of HMBC Correlation Networks: A Novel NMR-Based Contribution to Metabolite Mixture Analysis
BIreactive: A Machine-Learning Model to Estimate Covalent Warhead Reactivity
A simple algorithm for sorting chemical names
Simulated Annealing Search Algorithm for the Determination of Activation Energies and Arrhenius Prefactors from Limited Experimental Kinetic Data
DISE: Directed Sphere Exclusion
SynthMol: A Drug Safety Prediction Framework Integrating Graph Attention and Molecular Descriptors into Pre-Trained Geometric Models
DCABM-TCM: A Database of Constituents Absorbed into the Blood and Metabolites of Traditional Chinese Medicine
A Practical Algorithm to Solve the Near-Congruence Problem for Rigid Molecules and Clusters
Hydrogen Bonding Promoted Tautomerism between Azo and Hydrazone Forms in Calcon with Multistimuli Responsiveness and Biocompatibility
ReactionPredictor: Prediction of Complex Chemical Reactions at the Mechanistic Level Using Machine Learning
3D Connectivity Indices in QSPR/QSAR Studies
Substructure Search with Tree-Structured Data
Anisotropic Solvent Model of the Lipid Bilayer. 2. Energetics of Insertion of Small Molecules, Peptides, and Proteins in Membranes
Outlook on the Development and Application of Molecular Simulations in Latin America
Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme
Sharing Chemical Relationships Does Not Reveal Structures
Mechanistic Insight into the Chemiluminescent Decomposition of Cypridina Dioxetanone and the Chemiluminescent, Fluorescent Properties of the Light Emitter of Cypridina Bioluminescence
Fuzzy hierarchical cross-classification of Greek muds
Solvent Accessibility Promotes Rotamer Errors during Protein Modeling with Major Side-Chain Prediction Programs
Chemical substance retrieval system for searching generic representations. 1. A prototype system for the gazetted list of Existing Chemical Substances of Japan
In Silico Fragment-Based Drug Discovery: Setup and Validation of a Fragment-to-Lead Computational Protocol Using S4MPLE
Modeling Drug Albumin Binding Affinity with E-State Topological Structure Representation
Advancing Women in Chemistry: A Step Toward Gender Parity
Important Mathematical Structures of the Topological Index Z for Tree Graphs
Fragment-Based de Novo Ligand Design by Multiobjective Evolutionary Optimization
CS-Annotate: A Tool for Using NMR Chemical Shifts to Annotate RNA Structure
Group-Theoretical Discussion on the E / Z -Nomenclature for Ethylene Derivatives. Discrimination between RS -Stereoisomeric Groups and Stereoisomeric Groups
Projector-Based Embedding Eliminates Density Functional Dependence for QM/MM Calculations of Reactions in Enzymes and Solution
Populating Chemical Space with Peptides Using a Genetic Algorithm
graphLambda: Fusion Graph Neural Networks for Binding Affinity Prediction
ANN Multiscale Model of Anti-HIV Drugs Activity vs AIDS Prevalence in the US at County Level Based on Information Indices of Molecular Graphs and Social Networks
Quantitative Structure-Activity Relationship Studies of Progesterone Receptor Binding Steroids
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT 3 A, Histamine H 1 , and Histamine H 4 Receptors
MOLY-An Interactive System for Molecular Analysis
Rotagraphs and Their Generalizations
Generalized Theoretical and Practical Treatment of the Kinetics of an Enzyme-Catalyzed Reaction in the Presence of an Enzyme Equimolar Irreversible Inhibitor
Prediction of pK Values, Half-Lives, and Electronic Spectra of Flavylium Salts from Molecular Structure
Machine Learning Models Based on Molecular Fingerprints and an Extreme Gradient Boosting Method Lead to the Discovery of JAK2 Inhibitors
In Silico Screening of Small Molecule Inhibitors for Amyloid-β Aggregation
The development of an Environmental Fate Data Base
Graph Invariants for Fullerenes
HELM: A Hierarchical Notation Language for Complex Biomolecule Structure Representation
Applications of Discrete Shmaliy Moments on the Quantitative Analysis of Multitarget Compounds Based on the Chemical Spectra
Clar Theory for Radical Benzenoids
Learning Electronic Polarizations in Aqueous Systems
Augmenting MACCS Keys with Persistent Homology Fingerprints for Protein-Ligand Binding Classification
Computational Study on the Drug Resistance Mechanism against HCV NS3/4A Protease Inhibitors Vaniprevir and MK-5172 by the Combination Use of Molecular Dynamics Simulation, Residue Interaction Network, and Substrate Envelope Analysis
Modeling with Alternate Locations in X-ray Protein Structures
Correlation between Structure and Normal Boiling Points of Acyclic Carbonyl Compounds
Flexible 3D searching: The directed tweak technique
Enumeration and classification of coronoid hydrocarbons. 10. Double coronoids
Promolecules with a subsymmetry of D.infin.h. Combinatorial enumeration and stereochemical properties
STOPLIGHT: A Hit Scoring Calculator
Symmetrical "I"-Shaped Hyperbranched Structural-Repeating-Unit (SRU) Polymers: Converting Unregistrable SRUs to SRUs Registrable by Chemical Abstracts Service's Registry System
MINITAB Release 14
Vina-CUDA: An Efficient Program with in-Depth Utilization of GPU to Accelerate Molecular Docking
ParAMS: Parameter Optimization for Atomistic and Molecular Simulations
Computer-Assisted Mechanistic Evaluation of Organic Reactions. 25. Structure Diagram Positioning
Efficient Substructure Searching of Large Chemical Libraries: The ABCD Chemical Cartridge
Exhaustively Exploring the Prevalent Interaction Pathways of Ligands Targeting the Ligand-Binding Pocket of Farnesoid X Receptor via Combined Enhanced Sampling
Predictions of Binding for Dopamine D2 Receptor Antagonists by the SIE Method
Building Machine Learning Small Molecule Melting Points and Solubility Models Using CCDC Melting Points Dataset
Toward High Throughput 3D Virtual Screening Using Spherical Harmonic Surface Representations
Improved Computation of Protein-Protein Relative Binding Energies with the Nwat-MMGBSA Method
Selective Inhibitor Design for Kinase Homologs Using Multiobjective Monte Carlo Tree Search
Correlation Analyses on Binding Affinity of Substituted Benzenesulfonamides with Carbonic Anhydrase Using ab Initio MO Calculations on Their Complex Structures
Comparison of hierarchical cluster analysis techniques for automatic classification of chemical structures
HyperChem release 2 for the silicon graphics workstation
Dual Histamine H 3 R/Serotonin 5-HT 4 R Ligands with Antiamnesic Properties: Pharmacophore-Based Virtual Screening and Polypharmacology
Chemoinformatic Analysis of NCI Preclinical Tumor Data: Evaluating Compound Efficacy from Mouse Xenograft Data, NCI-60 Screening Data, and Compound Descriptors
On the Characterization of Molecular Stereostructure: 1. Cis-Trans Isomerism
ERRα-Predictor: A Framework of Ensemble Models for Prediction of ERRα Binders, Antagonists, and Agonists Using Artificial Intelligence
Do Chemformers Dream of Organic Matter? Evaluating a Transformer Model for Multistep Retrosynthesis
The CONTU guidelines and the transfer of scientific information: fair use or unfair use?
RASSE: A New Method for Structure-Based Drug Design
Structure elucidation system using structural information from multisources: CHEMICS
Special Issue on Reaction Informatics and Chemical Space
MambaTransDTA: A Hybrid Mamba-Transformer Architecture for Accurate Drug-Target Binding Affinity Prediction
Novel Inhibitors of Trihydroxynaphthalene Reductase with Antifungal Activity Identified by Ligand-Based and Structure-Based Virtual Screening
On 3-D Graphical Representation of DNA Primary Sequences and Their Numerical Characterization
mycoCSM: Using Graph-Based Signatures to Identify Safe Potent Hits against Mycobacteria
Machine Learning Classification and Structure-Functional Analysis of Cancer Mutations Reveal Unique Dynamic and Network Signatures of Driver Sites in Oncogenes and Tumor Suppressor Genes
Nonlinear Multivariate Regression Outperforms Several Concisely Designed Neural Networks on Three QSPR Data Sets
A New Approach of Evaluating Bond Dissociation Energy from Eigenvalue of Bonding Orbital-Connection Matrix for C-C and C-H Bonds in Alkane
Enhancing Toxicity Prediction of Synthetic Chemicals via Novel SMILES Fragmentation and Interpretable Deep Learning
CrystalDock: A Novel Approach to Fragment-Based Drug Design
Toward Explainable Carcinogenicity Prediction: An Integrated Cheminformatics Approach and Consensus Framework for Possibly Carcinogenic Chemicals
Studies of the Mechanism of Selectivity of Protein Tyrosine Phosphatase 1B (PTP1B) Bidentate Inhibitors Using Molecular Dynamics Simulations and Free Energy Calculations
Catalytic Site pKa Values of Aspartic, Cysteine, and Serine Proteases: Constant pH MD Simulations
Quantitative Characterization of Binding Pockets and Binding Complementarity by Means of Zernike Descriptors
Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models
On the Physical Interpretation of QSAR Models
SVM Model for Virtual Screening of Lck Inhibitors
Combinatorial Library Enumeration and Lead Hopping using Comparative Interaction Fingerprint Analysis and Classical 2D QSAR Methods for Seeking Novel GABA A α 3 Modulators
Data Management System for Distributed Virtual Screening
Combinatorial Chemistry and Molecular Diversity. An Overview
A Catalogue of Isomerization Transformations of Fullerene Polyhedra
QSAR Modeling Using Large-Scale Databases: Case Study for HIV-1 Reverse Transcriptase Inhibitors
Parallel Implementation of a Monte Carlo Molecular Simulation Program
Quick-and-Easy Validation of Protein-Ligand Binding Models Using Fragment-Based Semiempirical Quantum Chemistry
Predicting Physical-Chemical Properties of Compounds from Molecular Structures by Recursive Neural Networks
Improving Protein-Peptide Docking Results via Pose-Clustering and Rescoring with a Combined Knowledge-Based and MM-GBSA Scoring Function
An efficient graph approach to matching chemical structures
Celebrating the Next Generation of Women in Computational Chemistry to Increase Diversity, Equity, Inclusion, and Respect
CKB - The Compound Knowledge Base: A Text Based Chemical Search System
HybridMolDB: A Manually Curated Database Dedicated to Hybrid Molecules for Chemical Biology and Drug Discovery
Proposal of a 3D Peptide Pharmacophore of Muramyl Dipeptide-Type Immunostimulants. 1. Conformational Search of Active and Inactive Analogues
Solving Incomplete Inorganic Chemical Systems through a Fuzzy Knowledge Frame
GroScore: Accurate Scoring of Protein-Protein Binding Poses Using Explicit-Solvent Free-Energy Calculations
Analysis of Conformational Coverage, 2. Applications of Conformational Models
Widespread Misinterpretation of p K a Terminology for Zwitterionic Compounds and Its Consequences
Structural Insights into Pseudomonas aeruginosa Exotoxin A-Elongation Factor 2 Interactions: A Molecular Dynamics Study
Making Soup: Preparing and Validating Models of the Bacterial Cytoplasm for Molecular Simulation
IgG1-b12-HIV-gp120 Interface in Solution: A Computational Study
Real External Predictivity of QSAR Models: How To Evaluate It? Comparison of Different Validation Criteria and Proposal of Using the Concordance Correlation Coefficient
Protein Flexibility in Docking-Based Virtual Screening: Discovery of Novel Lymphoid-Specific Tyrosine Phosphatase Inhibitors Using Multiple Crystal Structures
Ringtail: A Python Tool for Efficient Management and Storage of Virtual Screening Results
Ligand-Based Target Prediction with Signature Fingerprints
EMOCPD: Efficient Attention-Based Models for Computational Protein Design Using Amino Acid Microenvironment
Molecular Modeling of the Interactions between Carborane-Containing Analogs of Indomethacin and Cyclooxygenase-2
Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods
Modern Conformational Analysis. Elucidating Novel Exciting Molecular Structures. Helena Dodziuk. VCH: New York, 1995, 264 pp, ISBN 1-56081-689-9
Wiener Index Extension by Counting Even/Odd Graph Distances
Quantifying the Separation of Positive and Negative Areas in Electrostatic Potential for Predicting Feasibility of Ammonium Sulfate for Protein Crystallization
Numerical Bounds for the Perfect Matching Vectors of a Polyhex
Computational Studies Suggest Promiscuous Candida antarctica Lipase B as an Environmentally Friendly Alternative for the Production of Epoxides
Revealing the Structural Contributions to Thermal Adaptation of the TATA-Box Binding Protein: Molecular Dynamics and QSPR Analyses
Comparison of Ridge Regression, Partial Least-Squares, Pairwise Correlation, Forward- and Best Subset Selection Methods for Prediction of Retention Indices for Aliphatic Alcohols
Similarity Searching and Clustering of Chemical-Structure Databases Using Molecular Property Data
Stability and Properties of Polyhelicenes and Annelated Fused-Ring Carbon Helices: Models Toward Helical Graphites
Computational Analysis of HIV-1 Protease Protein Binding Pockets
Similarity Measures: Is It Possible To Compare Dissimilar Structures?
Boosting Free-Energy Perturbation Calculations with GPU-Accelerated NAMD
Applicability Domain Analysis (ADAN): A Robust Method for Assessing the Reliability of Drug Property Predictions
Enabling In-Silico Hit Discovery Workflows Targeting RNA with Small Molecules
High-Order Quantum-Mechanical Analysis of Hydrogen Bonding in Hachimoji and Natural DNA Base Pairs
Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity
MiMiCPy: An Efficient Toolkit for MiMiC-Based QM/MM Simulations
Correction to Capturing the Crystal: Prediction of Enthalpy of Sublimation, Crystal Lattice Energy, and Melting Points of Organic Compounds
Structural Mechanism of ω-Currents in a Mutated Kv7.2 Voltage Sensor Domain from Molecular Dynamics Simulations
HORACE: An automatic system for the hierarchical classification of chemical reactions
A Partition Coefficient Calculation Method with the SFED Model
Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase
Identification of a New Binding Site in E. coli FabH using Molecular Dynamics Simulations: Validation by Computational Alanine Mutagenesis and Docking Studies
Molecular Dynamics Studies of the Protein-Protein Interactions in Inhibitor of κB Kinase-β
Chemistry Software Package ChemOffice Ultra 2005
In Silico Fragment Screening by Replica Generation (FSRG) Method for Fragment-Based Drug Design
Ranking Targets in Structure-Based Virtual Screening of Three-Dimensional Protein Libraries: Methods and Problems
History of citation indexes for chemistry: a brief review
Socioeconomic aspects of materials data: serving the user
Decoding the Structure-Activity Relationship of the Dopamine D3 Receptor-Selective Ligands Using Machine and Deep Learning Approaches
Qsarna: An Online Tool for Smart Chemical Space Navigation in Drug Design
Assessment of Embedding Schemes in a Hybrid Machine Learning/Classical Potentials (ML/MM) Approach
Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical-Genetic Interactions
Light-Induced Change of Arginine Conformation Modulates the Rate of Adenosine Triphosphate to Cyclic Adenosine Monophosphate Conversion in the Optogenetic System Containing Photoactivated Adenylyl Cyclase
In Silico Evolution of High-Performing Metal Organic Frameworks for Methane Adsorption
Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters - An in Silico Modeling Approach
Large-Scale Parallel Implementation of Hartree-Fock Exchange Energy on Real-Space Grids Using 3D-Parallel Fast Fourier Transform
CLCA: Maximum Common Molecular Substructure Queries within the MetRxn Database
Predicting Potent Compounds via Model-Based Global Optimization
Prebound State Discovered in the Unbinding Pathway of Fluorinated Variants of the Trypsin-BPTI Complex Using Random Acceleration Molecular Dynamics Simulations
An Automated Intermolecular Reaction Discovery Approach Relying on Heuristic Atom-Partitioned Frontier Orbital Features
Distance-Aware Molecular Property Prediction in Nonlinear Structure-Property Space
Copyright Impacts of Future Technology
Synthon-Based Strategies Exploiting Molecular Similarity and Protein-Ligand Interactions for Efficient Screening of Ultra-Large Chemical Libraries
p K a Calculations of GPCRs: Understanding Protonation States in Receptor Activation
Split Membrane: A New Model to Accelerate All-Atom MD Simulation of Phospholipid Bilayers
Application of the Maximal Common Substructure Algorithm to Automatic Interpretation of 13C-NMR Spectra
Correlation of Entropy with Similarity and Symmetry