To decide between these alternatives, we recorded from motionsensitive neurons in flies in which the output from either L1 or L2 was genetically blocked. We found that blocking L1 abolishes ON-ON responses but leaves OFF-OFF responses intact. The opposite was true, when the output from L2 was blocked. We conclude that the L1 and L2 pathways are functionally specialized to detect ON-ON and OFF-OFF sequences, respectively.
To decide between these alternatives, a case study via genetically blocking either ON/OFF pathway gave strong evidence to the functional specialized two versus six quadrants signal flows REF .
Functional Specialization of Parallel Motion Detection Circuits in the Fly
The Journal of neuroscience : the official journal of the Society for Neuroscience
The Journal of neuroscience : the official journal of the Society for Neuroscience
Biology Medicine