This paper studies the problem of learning diagnostic policies from training examples. A diagnostic policy is a complete description of the decision-making actions of a diagnostician (i.e., tests followed by a diagnostic decision) for all possible combinations of test results. An optimal diagnostic policy is one that minimizes the expected total cost, which is the sum of measurement costs and misdiagnosis costs. In most diagnostic settings, there is a tradeo between these two kinds of costs. This paper formalizes diagnostic decision making as a Markov Decision Process (MDP). The paper introduces a new family of systematic search algorithms based on the AO algorithm to solve this MDP. To make AO e cient, the paper describes an admissible heuristic that enables AO to prune large parts of the search space. The paper also introduces several greedy algorithms including some improvements over previously-published methods. The paper then addresses the question of learning diagnostic policies from examples. When the probabilities of diseases and test results are computed from training data, there is a great danger of over tting. To reduce over tting, regularizers are integrated into the search algorithms. Finally, the paper compares the proposed methods on ve benchmark diagnostic data sets. The studies show that in most cases the systematic search methods produce better diagnostic policies than the greedy methods. In addition, the studies show that for training sets of realistic size, the systematic search algorithms are practical on today's desktop computers.
REF formulated the cost-sensitive learning problem as a Markov Decision Process (MDP), and used a systematic search algorithm based on the AO* heuristic search procedure to solve the MDP.
Integrating Learning from Examples into the Search for Diagnostic Policies
Journal Of Artificial Intelligence Research, Volume 24, pages 263-303, 2005
Computer Science