comment reviews reports deposited research interactions information refereed research Background: Microarray technology is increasingly being applied in biological and medical research to address a wide range of problems, such as the classification of tumors. An important statistical problem associated with tumor classification is the identification of new tumor classes using gene-expression profiles. Two essential aspects of this clustering problem are: to estimate the number of clusters, if any, in a dataset; and to allocate tumor samples to these clusters, and assess the confidence of cluster assignments for individual samples. Here we address the first of these problems. We have developed a new prediction-based resampling method, Clest, to estimate the number of clusters in a dataset. The performance of the new and existing methods were compared using simulated data and gene-expression data from four recently published cancer microarray studies. Clest was generally found to be more accurate and robust than the six existing methods considered in the study. Focusing on prediction accuracy in conjunction with resampling produces accurate and robust estimates of the number of clusters. comment reviews reports deposited research interactions information refereed research http://genomebiology.com/2002/3/7/research/0036.3 DNA microarrays. Bioinformatics 2001, 17:520-525. comment reviews reports deposited research interactions information refereed research
REF proposed a re-sampling method called Clest to estimate the number of clusters (K) by repeatedly and randomly dividing the original dataset into two nonoverlapping sets.
A prediction-based resampling method for estimating the number of clusters in a dataset
Genome Biology
Genome Biology
Biology Medicine