Advances in proteomics technology have enabled new proteins to be discovered at an unprecedented speed, and high throughput experimental methods have been developed to detect protein interactions and complexes en masse. Such bottom-up, datadriven approach has resulted in data that may be uninformative or potentially errorful, requiring further validation and annotation. The InterDom database focuses on providing supporting evidence for the detected protein interactions based on putative protein domain interactions. Using an integrative approach, InterDom derives potential domain interactions by combining data from multiple sources, ranging from domain fusions, protein interactions and complexes, to scientific literature. The InterDom database is available at http:// InterDom.lit.org.sg.
They then inferred putative domaindomain interactions based on the collected data through the development of InterDom, a database of interacting domains (http://interdom.lit.org.sg) REF .
InterDom: a database of putative interacting protein domains for validating predicted protein interactions and complexes
Nucleic acids research
Nucleic acids research
Computer Science Biology Medicine