Summary: IPPRED is a web based server to infer proteinprotein interactions through homology search between candidate proteins and those described as interacting. This simple inference allows to propose or to validate potential interactions. Availability: IPPRED is freely available at http://cbi.labri. fr/outils/ippred/ Contact: Antoine.daruvar@pmtg.u-bordeaux2.fr The knowledge of interactions between proteins is necessary for understanding cell functions. The identification of these interactions is the subject of several projects ranging from small to large scale. These projects use various experimental approaches such as twohybrid screening or purification of complexes followed by the characterization of their components. In order to help biologists we have developed IPPRED, a web based server. IPPRED infers interactions through homology search between candidate proteins and those described as interacting. There are several known biological contexts which justify such inference. It's the case of conserved interactions between orthologous proteins, such as ribosomal proteins or the ATPase. It's also the case when interacting domains are found in different paralogous pairs, such as in CDK/cyclin complexes.
Goffard et al. REF developed IPPRED, a web-based server for the inference of proteins interactions.
IPPRED: server for proteins interactions inference
Bioinformatics
Bioinformatics
Medicine Computer Science