Protein sequence alignment is the task of identifying evolutionarily or structurally related positions in a collection of amino acid sequences. Although the protein alignment problem has been studied for several decades, many recent studies have demonstrated considerable progress in improving the accuracy or scalability of multiple and pairwise alignment tools, or in expanding the scope of tasks handled by an alignment program. In this chapter, we review state-of-the-art protein sequence alignment and provide practical advice for users of alignment tools.
Multiple sequence alignment has been studied extensively for the past several decades (see REF for reviews).
Protein Multiple Sequence Alignment
Methods in molecular biology
Methods in molecular biology
Computer Science Medicine