SOCS3

細胞因子信號傳導抑制因子3(SOCS3或 SOCS-3)是一種在人體內由 SOCS3基因編碼的蛋白。該基因編碼 STAT- 誘導的 STAT 抑制子(SSI)，也可稱為細胞因子信號轉導(SOCS)家族抑制子，的一個成員。SSI 家族成員是可由細胞因子誘導的細胞因子信號轉導負調節因子。

## 功能

SOCS3基因的表達可由多種細胞因子的誘導，包括 IL-6，IL-10，干擾素-γ(IFN-γ)。

在 IL-6，Epo，GCSF 和瘦素的信號傳導中，已發現SOCS3在各自的細胞因子受體上的結合對 SOCS3的抑制功能而言是至關重要的。

SOCS3的過表達會抑制脂肪組織和肝臟胰島素信號轉導，但對肌肉則不然。但是在小鼠骨骼肌中敲除 SOCS3可以保護小鼠免於肥胖相關的胰島素抵抗。

由於神經醯胺合成的增加，SOCS3會增加瘦素抵抗和胰島素抵抗。因此，研究已表明去除 SOCS 基因可以預防肥胖症患者的胰島素抵抗

對該小鼠中基因的同源基因的研究表明，該基因在胎兒肝臟造血和胎盤發育的負調控中發揮作用。

SOCS3蛋白能與JAK2結合，抑制其活性。

## 相互作用

已經證明 SOCS3可以與下列物質相互作用:

- 促紅細胞生成素受體
- 糖蛋白130
- 胰島素樣生長因子1受體
- JAK2
- PTPN11
- RAS p21蛋白激活因子1

## 調控

有部分證據表明 SOCS3的表達受小分子核糖核酸 miR-203的調控。

## 擴展閱讀

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