王陸海

王陸海（1947年），臺灣分子生物學家與腫瘤學家。

## 生平

出生於台灣，曾為美國西奈山醫學中心微生物學、癌症中心、腫瘤科學系正教授，回台灣進入國家衛生研究院 (代理院長)、中央研究院院士，2012年當選TWAS (The Academy of Sciences for the developing world, TWAS發展中世界科學院)院士。主要研究癌症防治、腫瘤學、分子生物學。現為中國醫藥大學副校長暨中醫學院中西醫結合研究所講座教授，國立臺灣大學分子與細胞生物學研究所、國立中央大學生命科學系與清華大學兼任教授，同時也是美國華陽生命科學股份有限公司 (Sun Farm Corp.) 科學委員、億康生物科技股份有限公司董事。

## 專業

- 癌症生物學 (Cancer Biology)
- 分子生物學 (Molecular biology)
- 華陽複方( Selected Vegetables,SV)
- 赫保康( HBK )

## 研究團隊

- 孫士銧
- 孫達士
- 楊思標
- 林瑞雄
- 毛仁淡
- Henry sacks
- Thomas M. Fasy

## 著作

- 1.Sachdev, P., Zeng, L. and Wang, L.-H. (2002). Distinct role of hosphotidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. J. Biol. Chem. 277:17638-17648.
- 2.Le, Maithao N., Kohanski, Ronald.A., Wang, Lu-Hai and Sadowski, Henry (2002). Dual mechanism of signal transduccer and activator of transcription 5 (Stat5) activation by the insulin receptor. Molecular Endocrinology 16:2764-2779.
- 3.Uttamsingh, Shailaja, Zong, Cong S. and Wang, Lu-Hai (2003). Matrix-independent activation of PI3 kinase, Stat3 and cyclin A-associated Cdk2 is essential for anchorage independent growth of v-Ros transformed chicken embryo fibroblasts. J. Biol. Chem. 278:18798-18810.
- 4.Wang, Lu-Hai (2004) Molecular signaling regulating anchorage-independent growth of cancer cells. The Mount Sinai J. of Medicine 71:361-367.
- 5.Lopewz-Bergami, P., Hasen H., Bhoumik, A, Zhang, W., Wang L.-H., and Ronai, Z. (2005) Receptor for RACK1 mediates activation of JNK by protein kinase C. Mol. Cell 19:309-320.
- 6.Zhang, W., Zong, C. S., Hermanto, U., Lopez-Bergami, P., Ronai, Z. and Wang, L.-H. (2005) RACK1 recruits STAT3 specifically to insulin and IGF-1 receptors for activation, which is important for regulating anchorage independent growth. Mol. Cell Biol. 26:413-424.
- 7.Yio, X., Diamond, M., Zhang, J.-Y., Weinstein, H., Wang, L.-H., Werther, L. and Itzkowitz, S. (2006) Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Gastroenterology 130:1696-706.
- 8.Dong, Z., Liu, Y., Lu, S., Wang, A., Lee, K., Wang, L.-H., Revdo, M. and Lu, S. (2006) Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Mol Endo. 20:2315-2325.
- 9.Cheng, G. Z., Chan, J., Sun, C.D., Wang, Q., Zhang, W. and Wang, L.-H. (2007). Twist transcriptionally upregulates AKT2 in invasive breast cancer cells leading to increased migration and survival. Cancer Research 67:1979-87.
- 10.Wang, L.-H., Chan, J. L.-K. and Li, W. (2007) Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells. Intl. J. Cancer 157-164.
- 11.K Masker, A. Golden, C. J. Gaffney, V. Mazack, W. F. Schwindinger, W. Zhang, L.-H. Wang, D.J. Carey and M. Sudol (2007). Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral src. Virology 364:10-20.
- 12.Cheng G Z, Zhang W, Wang L.-H. (2008) Regulation of cancer cell survival, migration and invasion by Twist: AKT2 comes to interplay. Cancer Research 68:957-960.
- 13.Uttamsingh, S, Bao, X., Nguyen, K. T., Bhanot M., Chan J. L.-K., Liu F, Chu T. and Wang, L-H. (2008) Synergistic effect between EGF and TGF-1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27:2626-2634.
- 14.Cheng G Z, Zhang W, Sun M, Wang, Q, Coppola D, Costanzo C, Xu L M, Chan J, Cheng J Q, Wang L-H. (2008) Twist is Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. JBC 283:14665-73.
- 15.Cheng G. Z., Park S., Shu S., He L., Kong W., Zhang W., Yuan Z., Wang L.-H., Cheng J. Q. (2008) Advances of AKT pathway in human oncogenesis and as a target for anti- cancer drug discovery. Current Cancer Drug Targets 8:2-6.
- 16.Wang, L.-H. (2008) Overview of modular domains and adaptor proteins, pp1-32 in 「Adaptor proteins and cancer」 Ed. M. Georges, Transworld Research Network, Trivandrum-695 023, Kerala, India.
- 17.Zhang W., Cheng G. Z., Hermanto U., Zong C. S., Chan J., Cheng J. and Wang, L.-H. (2008) RACK1 and CIS mediate the degradation of BimEL in cancer cells. JBC 283:16416-26.
- 18.Schlosshauer, P.W., Li, W., Lin, Kai-Ti., Chan, J. L-K. and Wang, L.-H. (2009) Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells. Gynecologic Oncology 114:516-522.
- 19.Jiang SS, Fang WT, Hou YH, Huang SF, Yen BL, Chang JL, Li SM, Liu HP, Liu YL, Huang CT, Li YW, Jang TH, Chan SH, Yang SJ, Hsiung CA, Wu CW, Wang LH, Chang IS. Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res. 2010 Sep 1;16(17):4363-73. doi: 10.1158/1078-0432.CCR-10-0138. Epub 2010 Jul 22
- 20.Tsai YC, Pestka S, Wang LH, Runnels L W, Wan S, Lyu YL and Liu L F. (2011) Interferon-β Autocrine Signaling Promotes Oncogenic Ras-Induced Cell Transformation. PLoS ONE 6(8): e24291, 1-8.
- 21.Lin, K.T. , Gong, J, Jang, T. H., Chen, H. J., Li, J. F. and Wang, L-H. (2012) EphA2-Vav3-Rac1 signaling mediates migratory and invasive behavior of prostate cancer cells and correlates with the disease progression Cancer Research 72 (12):3000-3009.
- 22.Lin, K.-Y, Wang, L-H., Hsen, Y. -C., Fung, C. -L., Yang, H. -L., Senthil Kumar, K.J., Tai, C. and Uen, Y.-H. (2012) Clinical significance of creased guanine nucleotide exchange factor Vav3 expression in human gastric cancer. Molecular Cancer Research 10(6): 750-759.
- 23.HJ Shih, HH Chen, YA Chen, MH Wu, GG Liou, WW Chang, LY Chen, LH Wang, HL Hsu. Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity. Oncotarget. 2012 Nov;3(11):1401-1415.
- 24.Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL. The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. Cell Cycle. 2012 Mar 1;11(5):934-952
- 25.Yeh YM, Chuang CM, Chao KC, Wang LH. (2013) MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α. Int J Cancer. Aug 15;133(4):867-78.
- 26.Huang WC, Chan SH, Jang TH, Chang JW, Ko YC, Yen TC, Chiang SL, Chiang WF, Shieh TY, Liao CT, Juang JL, Wang HC, Cheng AJ, Lu YC, Wang LH. (2014) miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. Cancer Res. Feb 1;74(3):751-64.
- 27.Chan SH, Huang WC, Chang JW, Chang KJ, Kuo WH, Wang MY, Lin KY, Uen YH, Hou MF, Lin CM, Jang TH, Tu CW, Lee YR, Lee YH, Tien MT, Wang LH. (2014) MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis. Oncogene. Sep 4;33(36):4496-507
- 28.Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH. (2015) Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nat Commun. Jan 8;6:5917.
- 29.Chan SH, Wang LH. (2015) Regulation of cancer metastasis by microRNAs. J Biomed Sci. Jan 23;22:9.

## 基本資料

- 性別：男
- 出生地：中華民國臺灣省臺南縣斗六區斗南鎮
- 國籍：中華民國
- 學歷：雲林縣斗南國民學校、臺灣省立嘉義中學、國立臺灣大學動物學系、美國加州大學柏克萊分校分子生物學博士
- past：美國洛克菲勒大學博士後研究員、（1977年－1979年）、美國洛克菲勒大學助理教授（1979年－1985年）、美國西奈山醫學院微生物學副教授、（1985年－1988年）、美國國立衛生研究院研究員、（1986年－1992年）、美國西奈山醫學院微生物學終身教職副教授、（1988年－1992年）、美國衛生研究院考研審稿儲備、（1992年－）、美國西奈山醫學院微生物學、腫瘤學科學教授、（1992年-）、美國西奈山醫學院癌症中心教授、（1999年-2004年）、台灣國家衛生研究院特聘研究員兼主任、講座教授（2008年-）、台灣國家衛生研究院特聘研究員、專案講座教授（2017年-）、台灣中國醫藥大學副校長暨中西結合研究所教授、講座教授（2017年-）
- 組別：生命科學組
- 屆數：第28屆
- 當選年：2010年