贝匹罗韦森

贝匹罗韦森 （GSK3228836）是是英国葛兰素史克公司研发的反义寡核苷酸嵌合体药物，可用于治疗乙型肝炎。该药物通过特定核酸序列结合乙型肝炎病毒信使核糖核酸以阻止病毒蛋白合成，需每周注射一次。

2022年，葛兰素史克在《新英格兰医学杂志》发表的文章指出，两项临床试验“取得了具有统计学显著性和临床意义的功能性治愈率”，并计划于2026年4月前提交全球监管申请。

## 基本资料

- 状态：试验中
- C：230
- H：309
- N：88
- O：115
- 汉语拼音：19
- 硫化物（SO）：19
- CAS号：1403787-62-1
- UNII：Z87O6SM01N
- ChEMBL：4650468
- 3D模型（JSmol）：COCCOC@@H1C@H(O)C@@H(COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cc(C)c(=O)nHc3=O)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cc(C)c(N)nc3=O)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cc(C)c(=O)nHc3=O)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2CC@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(N)ncnc43)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cc(C)c(N)nc3=O)OC@@H2COP(O)(=S)OC@H2C@@H(OCCOC)C@H(n3cnc4c(=O)nHc(N)nc43)OC@@H2CO)OC@H1n1cc(C)c(N)nc1=O
- StdInChI：1S/C230H309N88O115P19S19/c1-92-46-299(226(332)276-172(92)231)127-36-97(415-434(337,453)381-57-113-104(43-134(400-113)309-82-269-145-189(309)281-219(242)290-200(145)325)422-441(344,460)380-56-112-101(40-131(399-112)306-79-263-139-177(236)251-73-257-183(139)306)424-443(346,462)387-63-121-156(166(370-30-20-360-10)210(409-121)312-85-264-140-178(237)252-74-258-184(140)312)430-450(353,469)393-69-125-160(170(374-34-24-364-14)215(413-125)317-90-274-150-194(317)286-224(247)295-205(150)330)432-449(352,468)389-65-120-155(165(369-29-19-359-9)209(408-120)303-50-96(5)197(322)298-230(303)336)427-448(351,467)392-68-124-159(169(373-33-23-363-13)214(412-124)316-89-273-149-193(316)285-223(246)294-204(149)329)429-445(348,464)386-62-118-152(320)162(366-26-16-356-6)207(406-118)301-47-93(2)173(232)277-227(301)333)108(395-127)52-376-436(339,455)419-102-41-132(307-80-267-143-187(307)279-217(240)288-198(143)323)402-115(102)59-383-439(342,458)418-100-39-130(305-78-262-138-176(235)250-72-256-182(138)305)397-110(100)54-378-438(341,457)417-99-38-129(304-77-261-137-175(234)249-71-255-181(137)304)398-111(99)55-379-440(343,459)421-105-44-135(310-83-270-146-190(310)282-220(243)291-201(146)326)401-114(105)58-382-435(338,454)416-98-37-128(300-49-95(4)196(321)297-229(300)335)396-109(98)53-377-437(340,456)420-103-42-133(308-81-268-144-188(308)280-218(241)289-199(144)324)403-116(103)60-384-442(345,461)423-106-45-136(311-84-271-147-191(311)283-221(244)292-202(147)327)404-117(106)61-385-444(347,463)428-157-122(410-211(167(157)371-31-21-361-11)313-86-265-141-179(238)253-75-259-185(141)313)66-391-452(355,471)433-161-126(414-216(171(161)375-35-25-365-15)318-91-275-151-195(318)287-225(248)296-206(151)331)70-394-451(354,470)431-158-123(411-212(168(158)372-32-22-362-12)314-87-266-142-180(239)254-76-260-186(142)314)67-390-447(350,466)426-154-119(407-208(164(154)368-28-18-358-8)302-48-94(3)174(233)278-228(302)334)64-388-446(349,465)425-153-107(51-319)405-213(163(153)367-27-17-357-7)315-88-272-148-192(315)284-222(245)293-203(148)328/h46-50,71-91,97-136,152-171,207-216,319-320H,16-45,51-70H2,1-15H3,(H,337,453)(H,338,454)(H,339,455)(H,340,456)(H,341,457)(H,342,458)(H,343,459)(H,344,460)(H,345,461)(H,346,462)(H,347,463)(H,348,464)(H,349,465)(H,350,466)(H,351,467)(H,352,468)(H,353,469)(H,354,470)(H,355,471)(H2,231,276,332)(H2,232,277,333)(H2,233,278,334)(H2,234,249,255)(H2,235,250,256)(H2,236,251,257)(H2,237,252,258)(H2,238,253,259)(H2,239,254,260)(H,297,321,335)(H,298,322,336)(H3,240,279,288,323)(H3,241,280,289,324)(H3,242,281,290,325)(H3,243,282,291,326)(H3,244,283,292,327)(H3,245,284,293,328)(H3,246,285,294,329)(H3,247,286,295,330)(H3,248,287,296,331)/t97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,152+,153+,154+,155+,156+,157+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,207+,208+,209+,210+,211+,212+,213+,214+,215+,216+,434?,435?,436?,437?,438?,439?,440?,441?,442?,443?,444?,445?,446?,447?,448?,449?,450?,451?,452?/m0/s1
- StdInChIKey：YQNJZPFGZLXVFA-VOYCTQJNSA-N
- IUPAC_name：all-P-ambo-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiocytidylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-P-thiothymidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-5-methyl-P-thiocytidylyl-(3'→5')-2'-deoxy-P-thioguanylyl-(3'→5')-2'-deoxy-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioadenylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methyl-P-thiouridylyl-(3'→5')-2'-O-(2-methoxyethyl)-P-thioguanylyl-(3'→5')-2'-O-(2-methoxyethyl)-5-methylcytidine