JWH大麻素列表

克莱门森大学的约翰·威廉·霍夫曼（John William Huffman）研究小组合成了450多种大麻素。其中一些是：

## 001—100

名称｜类别｜分子式｜Ki/nM (CB1)｜Ki/nM (CB2)｜选择性｜结构｜CAS编号

JWH-004｜萘甲酰基吲哚｜C26H27NO｜48 ± 13｜4 ± 1.5｜CB2 (12x)｜

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JWH-007｜萘甲酰基吲哚｜C25H25NO｜9.5 ± 4.5｜2.9 ± 2.6｜CB2 (3.3x)｜

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JWH-009｜萘甲酰基吲哚｜C27H29NO｜>10000｜141 ± 14｜CB2 (>70x)｜

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JWH-011｜萘甲酰基吲哚｜C27H29NO｜

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JWH-015｜萘甲酰基吲哚｜C23H21NO｜164 ± 22｜13.8 ± 4.6｜CB2 (12x)｜

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JWH-016｜萘甲酰基吲哚｜C24H23NO｜22 ± 1.5｜4.3 ± 1.6｜CB2 (5.1x)｜

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JWH-018｜萘甲酰基吲哚｜C24H23NO｜9 ± 5｜2.9 ± 2.6｜CB2 (3.1x)｜

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JWH-019｜萘甲酰基吲哚｜C25H25NO｜9.8 ± 2｜5.55 ± 2｜CB2 (1.77x)｜

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JWH-020｜萘甲酰基吲哚｜C26H27NO｜128 ± 17｜205 ± 20｜CB1 (1.6x)｜

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JWH-030｜萘甲酰基吡咯｜C20H21NO｜87 ± 3｜320 ± 127｜CB1 (3.7x)｜

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JWH-031｜萘甲酰基吡咯｜C21H23NO｜399 ± 109｜

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JWH-032｜萘甲酰基吡咯｜C18H17NO｜>10000｜>10000｜

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JWH-033｜萘甲酰基吡咯｜C19H19NO｜666 ± 77｜

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JWH-036｜萘甲酰基吡咯｜C22H25NO｜309 ± 11｜

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JWH-042｜萘甲酰基吲哚｜C21H17NO｜>10000｜5050 ± 192｜CB2｜

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JWH-043｜萘甲酰基吲哚｜C22H19NO｜1180 ± 44｜964 ± 242｜CB2 (1.2x)｜

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JWH-044｜萘甲酰基吡咯｜C16H13NO｜>10000｜>10000｜

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JWH-045｜萘甲酰基吡咯｜C17H15NO｜>10000｜>10000｜

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JWH-046｜萘甲酰基吲哚｜C24H23NO｜343 ± 38｜16.3 ± 4.9｜CB2 (21x)｜

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JWH-047｜萘甲酰基吲哚｜C25H25NO｜59 ± 3｜3.47 ± 1.80｜CB2 (17x)｜

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JWH-048｜萘甲酰基吲哚｜C26H27NO｜10.7 ± 1.0｜0.49 ± 0.13｜CB2 (22x)｜

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JWH-049｜萘甲酰基吲哚｜C27H29NO｜55.1 ± 17.0｜32.3 ± 2.4｜CB2 (1.7x)｜

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JWH-050｜萘甲酰基吲哚｜C28H31NO｜342 ± 6｜526 ± 133｜CB1 (1.5x)｜

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JWH-051｜二苯并吡喃｜C25H38O2｜1.20｜0.03｜CB2 (40x)｜

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JWH-056｜二苯并吡喃｜C21H30O｜>10000｜32 ± 9｜CB2｜

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JWH-057｜二苯并吡喃｜C25H38O｜23 ± 7｜2.9 ± 1.6｜CB2 (8x)｜

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JWH-065｜二苯并吡喃｜C23H34O｜399 ± 76｜10 ± 2｜CB2 (40x)｜

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JWH-070｜萘甲酰基吲哚｜C20H15NO｜>10000｜>10000｜

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JWH-071｜萘甲酰基吲哚｜C21H17NO｜1340 ± 123｜2940 ± 852｜CB1 (2.2x)｜

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JWH-072｜萘甲酰基吲哚｜C22H19NO｜1050 ± 5.5｜170 ± 54｜CB2 (6x)｜

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JWH-073｜萘甲酰基吲哚｜C23H21NO｜8.9 ± 1.8｜27 ± 12｜CB1 (3x)｜

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JWH-076｜萘甲酰基吲哚｜C23H21NO｜214 ± 11｜106 ± 46｜CB2 (2x)｜

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JWH-077｜萘甲酰基吲哚｜C21H17NO2｜>10000｜>10000｜

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JWH-078｜萘甲酰基吲哚｜C22H19NO2｜817 ± 60｜633 ± 116｜CB2 (1.3x)｜

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JWH-079｜萘甲酰基吲哚｜C23H21NO2｜63.0 ± 3.0｜32.0 ± 6.0｜CB2 (2x)｜

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JWH-080｜萘甲酰基吲哚｜C24H23NO2｜8.9 ± 1.8｜2.21 ± 1.30｜CB2 (4x)｜

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JWH-081｜萘甲酰基吲哚｜C25H25NO2｜1.2 ± 0.03｜12.4 ± 2.2｜CB1 (10x)｜

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JWH-082｜萘甲酰基吲哚｜C26H27NO2｜5.3 ± 0.8｜6.40 ± 0.94｜CB1 (1.2x)｜

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JWH-083｜萘甲酰基吲哚｜C27H29NO2｜106 ± 12｜102 ± 50｜

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JWH-091 (Δ8-THCP)｜二苯并吡喃｜C23H34O2｜22.0 ± 3.9｜

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JWH-093｜萘甲酰基吲哚｜C27H29NO2｜40.7 ± 2.8｜59.1 ± 10.5｜CB1 (1.45x)｜

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JWH-094｜萘甲酰基吲哚｜C24H23NO2｜476 ± 67｜97.3 ± 2.7｜CB2 (4.9x)｜

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JWH-095｜萘甲酰基吲哚｜C29H33NO2｜140 ± 4.3｜312 ± 83｜CB1 (2.2x)｜

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JWH-096｜萘甲酰基吲哚｜C25H25NO2｜33.7 ± 2.9｜13.3 ± 5.6｜CB2 (2.5x)｜

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JWH-097｜萘甲酰基吲哚｜C31H37NO2｜455 ± 28｜121 ± 15｜CB2 (3.8x)｜

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JWH-098｜萘甲酰基吲哚｜C26H27NO2｜4.5 ± 0.1｜1.9 ± 0.3｜CB2 (2.4x)｜

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JWH-099｜萘甲酰基吲哚｜C27H29NO2｜35.3 ± 9.0｜17.8 ± 2.9｜CB2 (2x)｜

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JWH-100｜萘甲酰基吲哚｜C28H31NO2｜381 ± 102｜155 ± 74｜CB2 (2.5x)｜

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## 101—200

名称｜类别｜分子式｜Ki/nM (CB1)｜Ki/nM (CB2)｜选择性｜结构｜CAS编号

JWH-102｜二苯并吡喃｜C24H38O2｜7.9 ± 0.9｜5.2 ± 2.0｜CB2 (1.5x)｜

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JWH-103｜二苯并吡喃｜C24H38O2｜28 ± 3｜23 ± 7｜CB2 (1.2x)｜

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JWH-116｜萘甲酰基吲哚｜C26H27NO｜52 ± 5｜

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JWH-120｜萘甲酰基吲哚｜C23H21NO｜1054 ± 31｜6.1 ± 0.7｜CB2 (173x)｜

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4'-甲基-JWH-073｜萘甲酰基吲哚｜C24H23NO｜

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JWH-122｜萘甲酰基吲哚｜C25H25NO｜0.69 ± 0.05｜1.2 ± 1.2｜

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JWH-124 (Δ8-Parahexyl)｜二苯并吡喃｜C22H32O2｜41.0 ± 3.8｜

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JWH-130 (Δ8-THCB)｜二苯并吡喃｜C20H28O2｜65.0 ± 13｜

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JWH-133｜二苯并吡喃｜C22H32O｜677 ± 132｜3.4 ± 1.0｜CB2 (200x)｜

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JWH-138｜二苯并吡喃｜C24H36O2｜8.5 ± 1.4｜

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JWH-139｜二苯并吡喃｜C21H30O｜2290 ± 505｜14 ± 10｜CB2 (164x)｜

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JWH-142｜二苯并吡喃｜C26H40O2｜529 ± 49｜35 ± 14｜CB2 (15x)｜

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JWH-143｜二苯并吡喃｜C26H40O2｜924 ± 104｜65 ± 8｜CB2 (14x)｜

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JWH-145｜萘甲酰基吡咯｜C26H25NO｜14 ± 2｜6.4 ± 0.4｜CB2 (2.2x)｜

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JWH-146｜萘甲酰基吡咯｜C28H29NO｜21 ± 2｜62 ± 5｜CB2 (3.0x)｜

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JWH-147｜萘甲酰基吡咯｜C27H27NO｜11 ± 1｜7.1 ± 0.2｜CB2 (1.5x)｜

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JWH-148｜萘甲酰基吲哚｜C24H23NO｜123 ± 8｜14.0 ± 1.0｜CB2 (8x)｜

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JWH-149｜萘甲酰基吲哚｜C26H27NO｜5.0 ± 2.1｜0.73 ± 0.03｜CB2 (6.8x)｜

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JWH-150｜萘甲酰基吡咯｜C25H23NO｜60 ± 1｜15 ± 2｜CB2 (4x)｜

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JWH-151｜萘甲酰基吲哚｜C24H23NO2｜>10000｜30 ± 1.1｜CB2 (>333x)｜

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JWH-153｜萘甲酰基吲哚｜C26H27NO2｜250 ± 24｜11 ± 0.5｜CB2 (23x)｜

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JWH-156｜萘甲酰基吡咯｜C24H21NO｜404 ± 18｜104 ± 18｜CB2 (4x)｜

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JWH-159｜萘甲酰基吲哚｜C26H27NO2｜45 ± 1｜10.4 ± 1.4｜CB2 (4.3x)｜

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JWH-160｜萘甲酰基吲哚｜C24H23NO2｜1568 ± 201｜441 ± 110｜CB2 (3.6x)｜

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JWH-161｜二苯并吡喃｜C27H33NO2｜19.0｜

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JWH-163｜萘甲酰基吲哚｜C23H21NO2｜2358 ± 215｜138 ± 12｜CB2 (17x)｜

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JWH-164｜萘甲酰基吲哚｜C25H25NO2｜6.6 ± 0.7｜6.9 ± 0.2｜

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JWH-165｜萘甲酰基吲哚｜C23H21NO2｜204 ± 26｜71 ± 8｜CB2 (2.9x)｜

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JWH-166｜萘甲酰基吲哚｜C25H25NO2｜44 ± 10｜1.9 ± 0.08｜CB2 (23x)｜

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JWH-167｜苯乙酰吲哚｜C21H23NO｜90 ± 17｜159 ± 14｜CB1 (1.77x)｜

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JWH-171｜碳氢｜C25H24｜51｜

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JWH-175｜萘甲基吲哚｜C24H25N｜22 ± 2｜

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JWH-176｜碳氢｜C25H24｜26 ± 4｜

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JWH-180｜萘甲酰基吲哚｜C25H25NO｜26 ± 2｜9.6 ± 2.0｜CB2 (2.7x)｜

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JWH-181｜萘甲酰基吲哚｜C28H31NO｜1.3 ± 0.1｜0.62 ± 0.04｜CB2 (2.1x)｜

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JWH-182｜萘甲酰基吲哚｜C27H29NO｜0.65 ± 0.03｜1.1 ± 0.1｜CB1 (1.7x)｜

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JWH-184｜萘甲基吲哚｜C25H27N｜23 ± 6｜

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JWH-185｜萘甲基吲哚｜C25H27NO｜17 ± 3｜

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JWH-186｜二苯并吡喃｜C21H30O2｜187 ± 23｜5.6 ± 1.7｜CB2 (33x)｜

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JWH-187｜二苯并吡喃｜C22H32O2｜84 ± 16｜3.4 ± 0.5｜CB2 (25x)｜

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JWH-188｜二苯并吡喃｜C20H28O2｜270 ± 58｜18 ± 2｜CB2 (15x)｜

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JWH-189｜萘甲酰基吲哚｜C26H27NO｜52 ± 2｜12 ± 0.8｜CB2 (4.3x)｜

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JWH-190｜二苯并吡喃｜C23H34O2｜8.8 ± 1.4｜1.6 ± 0.03｜CB2 (5.5x)｜

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JWH-191｜二苯并吡喃｜C24H36O2｜1.8 ± 0.3｜0.52 ± 0.03｜CB2 (3.5x)｜

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JWH-192｜萘甲基吲哚｜C26H28N2O｜41 ± 13｜

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JWH-193｜萘甲酰基吲哚｜C26H26N2O2｜6 ± 1｜

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JWH-194｜萘甲基吲哚｜C26H29N｜127 ± 19｜

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JWH-195｜萘甲基吲哚｜C25H26N2O｜113 ± 28｜

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JWH-196｜萘甲基吲哚｜C25H27N｜151 ± 18｜

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JWH-197｜萘甲基吲哚｜C26H29NO｜323 ± 98｜

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JWH-198｜萘甲酰基吲哚｜C26H26N2O3｜10 ± 2｜

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JWH-199｜萘甲基吲哚｜C26H28N2O2｜20 ± 2｜

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JWH-200｜萘甲酰基吲哚｜C25H24N2O2｜42 ± 5｜

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## 201—300

名称｜类别｜分子式｜Ki/nM (CB1)｜Ki/nM (CB2)｜选择性｜结构｜CAS编号

JWH-201｜苯乙酰吲哚｜C22H25NO2｜1064 ± 21｜444 ± 14｜CB2 (2.4x)｜

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JWH-202｜苯乙酰吲哚｜C23H27NO2｜1678 ± 63｜645 ± 6｜CB2 (2.6x)｜

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JWH-203｜苯乙酰吲哚｜C21H22ClNO｜8.0 ± 0.9｜7.0 ± 1.3｜

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JWH-204｜苯乙酰吲哚｜C22H24ClNO｜13 ± 1｜25 ± 1｜CB1 (1.9x)｜

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JWH-205｜苯乙酰吲哚｜C22H25NO｜124 ± 23｜180 ± 9｜CB1 (1.45x)｜

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JWH-206｜苯乙酰吲哚｜C21H22ClNO｜389 ± 25｜498 ± 37｜CB1 (1.28x)｜

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JWH-207｜苯乙酰吲哚｜C22H24ClNO｜1598 ± 134｜3723 ± 10｜CB1 (2.33x)｜

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JWH-208｜苯乙酰吲哚｜C22H25NO｜179 ± 7｜570 ± 127｜CB1 (3.18x)｜

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JWH-209｜苯乙酰吲哚｜C23H27NO｜746 ± 49｜1353 ± 270｜CB1 (1.81x)｜

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JWH-210｜萘甲酰基吲哚｜C26H27NO｜0.46 ± 0.03｜0.69 ± 0.01｜CB1 (1.5x)｜

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JWH-211｜萘甲酰基吲哚｜C25H25NO｜70 ± 0.8｜12 ± 0.8｜CB2 (5.8x)｜

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JWH-212｜萘甲酰基吲哚｜C24H23NO｜33 ± 0.9｜10 ± 1.2｜CB2 (3.3x)｜

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JWH-213｜萘甲酰基吲哚｜C27H29NO｜1.5 ± 0.2｜0.42 ± 0.05｜CB2 (3.6x)｜

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JWH-215｜二苯并吡喃｜C22H32O3｜1008 ± 117｜85 ± 21｜CB2 (12x)｜

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JWH-216｜二苯并吡喃｜C21H30O3｜1856 ± 148｜333 ± 104｜CB2 (5.6x)｜

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JWH-217｜二苯并吡喃｜C22H32O2｜>10000｜1404 ± 66｜CB2 (>7x)｜

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JWH-220｜碳氢｜C26H26｜19｜

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JWH-224｜二苯并吡喃｜C23H34O3｜347 ± 34｜28 ± 1｜CB2 (12.3x)｜

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JWH-225｜二苯并吡喃｜C23H34O2｜>10000｜325 ± 70｜CB2 (>31x)｜

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JWH-226｜二苯并吡喃｜C24H36O2｜4001 ± 282｜43 ± 3｜CB2 (93x)｜

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JWH-227｜二苯并吡喃｜C24H36O3｜40 ± 6｜4.4 ± 0.3｜CB2 (9x)｜

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JWH-229｜二苯并吡喃｜C25H38O2｜3134 ± 110｜18 ± 2｜CB2 (174x)｜

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JWH-230｜二苯并吡喃｜C25H38O3｜15 ± 3｜1.4 ± 0.12｜CB2 (10.7x)｜

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JWH-233｜二苯并吡喃｜C26H40O3｜14 ± 3｜1.0 ± 0.3｜CB2 (14x)｜

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｜（(6aR,10aR)）（(6aS,10aS)）

JWH-234｜萘甲酰基吲哚｜C26H27NO｜8.4 ± 1.8｜3.8 ± 0.6｜CB2 (2.2x)｜

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JWH-235｜萘甲酰基吲哚｜C24H23NO｜338 ± 34｜123 ± 34｜CB2 (2.7x)｜

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JWH-236｜萘甲酰基吲哚｜C25H25NO｜1351 ± 204｜240 ± 63｜CB2 (5.6x)｜

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JWH-237｜苯乙酰吲哚｜C21H22ClNO｜38 ± 10｜106 ± 2｜CB1 (2.8x)｜

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JWH-239｜萘甲酰基吲哚｜C26H27NO｜342 ± 20｜52 ± 6｜CB2 (6.6x)｜

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JWH-240｜萘甲酰基吲哚｜C28H31NO｜14 ± 1｜7.2 ± 1.3｜CB2 (1.9x)｜

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JWH-241｜萘甲酰基吲哚｜C27H29NO｜147 ± 20｜49 ± 7｜CB2 (3.0x)｜

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JWH-242｜萘甲酰基吲哚｜C29H33NO｜42 ± 9｜6.5 ± 0.3｜CB2 (6.5x)｜

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JWH-243｜萘甲酰基吡咯｜C27H27NO2｜285 ± 40｜41 ± 3｜CB2 (6.95x)｜

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JWH-244｜萘甲酰基吡咯｜C27H27NO｜130 ± 6｜18 ± 1｜CB2 (7.22x)｜

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JWH-245｜萘甲酰基吡咯｜C26H24ClNO｜276 ± 4｜25 ± 2｜CB2 (11x)｜

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JWH-246｜萘甲酰基吡咯｜C26H24ClNO｜70 ± 4｜16 ± 1｜CB2 (4.38x)｜

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JWH-247｜二苯并吡喃｜C25H38O2｜427 ± 31｜99 ± 4｜CB2 (4.3x)｜

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JWH-248｜苯乙酰吲哚｜C21H22BrNO｜1028 ± 39｜657 ± 19｜CB2 (1.56x)｜

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JWH-249｜苯乙酰吲哚｜C21H22BrNO｜8.4 ± 1.8｜20 ± 2｜CB1 (2.38x)｜

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JWH-250｜苯乙酰吲哚｜C22H25NO2｜11 ± 2｜33 ± 2｜CB1 (3x)｜

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JWH-251｜苯乙酰吲哚｜C22H25NO｜29 ± 3｜146 ± 36｜CB2 (5x)｜

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JWH-252｜苯乙酰吲哚｜C23H27NO｜23 ± 3｜19 ± 1｜CB2 (1.2x)｜

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JWH-253｜苯乙酰吲哚｜C23H27NO2｜62 ± 10｜84 ± 12｜CB1 (1.35x)｜

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JWH-254｜二苯并吡喃｜C23H34O2｜4724 ± 509｜319 ± 16｜CB2 (14.8x)｜

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JWH-256｜二苯并吡喃｜C24H36O2｜4300 ± 888｜97 ± 18｜CB2 (44x)｜

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JWH-258｜萘甲酰基吲哚｜C26H27NO2｜4.6 ± 0.6｜10.5 ± 1.3｜CB1 (2.3x)｜

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JWH-259｜萘甲酰基吲哚｜C24H23NO2｜220 ± 29｜74 ± 7｜CB2 (3.0x)｜

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JWH-260｜萘甲酰基吲哚｜C27H29NO2｜29 ± 0.4｜25 ± 1.9｜CB2 (1.2x)｜

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JWH-261｜萘甲酰基吲哚｜C25H25NO2｜767 ± 105｜221 ± 14｜CB2 (3.5x)｜

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JWH-262｜萘甲酰基吲哚｜C27H29NO｜28 ± 3｜5.6 ± 0.7｜CB2 (5.0x)｜

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JWH-265｜萘甲酰基吲哚｜C23H21NO2｜3788 ± 323｜80 ± 13｜CB2 (47x)｜

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JWH-266｜萘甲酰基吲哚｜C24H23NO2｜>10000｜455 ± 55｜CB2 (>22x)｜

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JWH-267｜萘甲酰基吲哚｜C25H25NO2｜381 ± 16｜7.2 ± 0.14｜CB2 (53x)｜

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JWH-268｜萘甲酰基吲哚｜C26H27NO2｜1379 ± 193｜40 ± 0.6｜CB2 (34x)｜

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JWH-277｜二苯并吡喃｜C22H34O3｜3905 ± 91｜589 ± 65｜CB2 (6.6x)｜

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JWH-278｜二苯并吡喃｜C23H36O3｜906 ± 80｜69 ± 6｜CB2 (13x)｜

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JWH-292｜萘甲酰基吡咯｜C27H27NO2｜29 ± 1｜20 ± 1｜CB2 (1.45x)｜

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JWH-293｜萘甲酰基吡咯｜C26H24N2O3｜100 ± 5｜41 ± 4｜CB2 (2.44x)｜

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JWH-298｜二苯并吡喃｜C22H34O3｜812 ± 67｜198 ± 23｜CB2 (4.1x)｜

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JWH-299｜二苯并吡喃｜C23H36O3｜415 ± 50｜30 ± 2｜CB2 (13.8x)｜

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JWH-300｜二苯并吡喃｜C22H34O2｜118 ± 16｜5.3 ± 0.1｜CB2 (22x)｜

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## 301—400

名称｜类别｜分子式｜Ki/nM (CB1)｜Ki/nM (CB2)｜选择性｜结构｜CAS编号

JWH-301｜二苯并吡喃｜C22H34O2｜295 ± 64｜48 ± 4｜CB2 (6.1x)｜

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JWH-302｜苯乙酰吲哚｜C22H25NO2｜17 ± 2｜89 ± 15｜CB1 (5.26x)｜

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JWH-303｜苯乙酰吲哚｜C22H24ClNO｜117 ± 10｜138 ± 12｜CB1 (1.18x)｜

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JWH-304｜苯乙酰吲哚｜C22H24BrNO｜3363 ± 332｜2679 ± 688｜CB2 (1.26x)｜

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JWH-305｜苯乙酰吲哚｜C22H24BrNO｜15 ± 1.8｜29 ± 5｜CB1 (1.93x)｜

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JWH-306｜苯乙酰吲哚｜C23H27NO2｜25 ± 1｜82 ± 11｜CB1 (3.28x)｜

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JWH-307｜萘甲酰基吡咯｜C26H24FNO｜7.7 ± 1.8｜3.3 ± 0.2｜CB2 (2.33x)｜

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JWH-308｜萘甲酰基吡咯｜C26H24FNO｜41 ± 1｜33 ± 2｜CB2 (1.24x)｜

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JWH-309｜萘甲酰基吡咯｜C30H27NO｜41 ± 3｜49 ± 7｜CB1 (1.20x)｜

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JWH-310｜二苯并吡喃｜C21H32O2｜1059 ± 51｜36 ± 3｜CB2 (29x)｜

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JWH-311｜苯乙酰吲哚｜C21H22FNO｜23 ± 2｜39 ± 3｜CB1 (1.70x)｜

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JWH-312｜苯乙酰吲哚｜C21H22FNO｜72 ± 7｜91 ± 20｜CB1 (1.26x)｜

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JWH-313｜苯乙酰吲哚｜C21H22FNO｜422 ± 19｜365 ± 92｜CB2 (1.16x)｜

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JWH-314｜苯乙酰吲哚｜C22H24FNO｜39 ± 2｜76 ± 4｜CB1 (1.95x)｜

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JWH-315｜苯乙酰吲哚｜C22H24FNO｜430 ± 24｜182 ± 23｜CB2 (3.36x)｜

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JWH-316｜苯乙酰吲哚｜C22H24FNO｜2862 ± 670｜781 ± 105｜CB2 (3.66x)｜

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JWH-336｜二苯并吡喃｜C21H32O2｜4589 ± 367｜153 ± 15｜CB2 (30x)｜

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JWH-338｜二苯并吡喃｜C20H28O｜>10000｜111 ± 16｜CB2 (>90x)｜

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JWH-339｜二苯并吡喃｜C21H30O2｜>10000｜2317 ± 93｜CB2 (>4.3x)｜

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JWH-340｜二苯并吡喃｜C25H40O3｜135 ± 6｜30 ± 1｜CB2 (4.5x)｜

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JWH-341｜二苯并吡喃｜C25H40O3｜100 ± 8｜10 ± 0.1｜CB2 (10x)｜

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JWH-346｜萘甲酰基吡咯｜C27H27NO｜67 ± 6｜39 ± 2｜CB2 (1.72x)｜

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JWH-347｜萘甲酰基吡咯｜C30H27NO｜333 ± 17｜169 ± 17｜CB2 (1.97x)｜

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JWH-348｜萘甲酰基吡咯｜C27H24F3NO｜218 ± 19｜53 ± 1｜CB2 (4.11x)｜

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JWH-349｜二苯并吡喃｜C24H38O3｜376 ± 1｜38 ± 4｜CB2 (9.9x)｜

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JWH-350｜二苯并吡喃｜C24H38O3｜395 ± 50｜12 ± 1｜CB2 (33x)｜

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JWH-351｜二苯并吡喃｜C22H32O2｜>10000｜295 ± 3｜CB2 (>34x)｜

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JWH-352｜二苯并吡喃｜C21H30O｜>10000｜47 ± 2｜CB2 (>213x)｜

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JWH-353｜二苯并吡喃｜C22H32O｜1493 ± 10｜31 ± 1｜CB2 (48x)｜

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JWH-354｜二苯并吡喃｜C23H34O2｜1961 ± 21｜241 ± 14｜CB2 (8.1x)｜

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JWH-355｜二苯并吡喃｜C23H34O｜2162 ± 220｜108 ± 17｜CB2 (20x)｜

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JWH-356｜二苯并吡喃｜C24H36O2｜5837 ± 701｜108 ± 17｜CB2 (54x)｜

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JWH-357｜二苯并吡喃｜C24H36O｜647 ± 78｜185 ± 4｜CB2 (3.5x)｜

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JWH-358｜二苯并吡喃｜C25H38O2｜1243 ± 266｜52 ± 3｜CB2 (24x)｜

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JWH-359｜二苯并吡喃｜C24H36O2｜2918 ± 450｜13.0 ± 0.2｜CB2 (220x)｜

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JWH-360｜二苯并吡喃｜C21H30O｜2449 ± 606｜160 ± 8｜CB2 (15x)｜

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JWH-361｜二苯并吡喃｜C23H36O2｜63 ± 3｜2.7 ± 0.1｜CB2 (23x)｜

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JWH-362｜二苯并吡喃｜C23H36O2｜127 ± 8｜34 ± 5｜CB2 (3.7x)｜

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JWH-363｜萘甲酰基吡咯｜C27H24F3NO｜245 ± 5｜71 ± 1｜CB2 (3.45x)｜

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JWH-364｜萘甲酰基吡咯｜C28H29NO｜34 ± 3｜29 ± 1｜CB2 (1.17x)｜

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JWH-365｜萘甲酰基吡咯｜C28H29NO｜17 ± 1｜3.4 ± 0.2｜CB2 (5.0x)｜

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JWH-366｜萘甲酰基吡咯｜C25H24N2O｜191 ± 12｜24 ± 1｜CB2 (7.96x)｜

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JWH-367｜萘甲酰基吡咯｜C27H27NO2｜53 ± 2｜23 ± 1｜CB2 (2.30x)｜

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JWH-368｜萘甲酰基吡咯｜C26H24FNO2｜16 ± 1｜9.1 ± 0.7｜CB2 (1.76x)｜

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JWH-369｜萘甲酰基吡咯｜C26H24ClNO2｜7.9 ± 0.4｜5.2 ± 0.3｜CB2 (1.52x)｜

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JWH-370｜萘甲酰基吡咯｜C27H27NO｜5.6 ± 0.4｜4.0 ± 0.5｜CB2 (1.40x)｜

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JWH-371｜萘甲酰基吡咯｜C30H33NO｜42 ± 1｜64 ± 2｜CB1 (1.52x)｜

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JWH-372｜萘甲酰基吡咯｜C27H24F3NO｜77 ± 2｜8.2 ± 0.2｜CB1 (9.39x)｜

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JWH-373｜萘甲酰基吡咯｜C30H33NO｜60 ± 3｜69 ± 2｜CB1 (1.15x)｜

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JWH-387｜萘甲酰基吲哚｜C24H22BrNO｜1.2 ± 0.1｜1.1 ± 0.1｜

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JWH-398｜萘甲酰基吲哚｜C24H22ClNO｜2.3 ± 0.1｜2.8 ± 0.2｜CB1 (1.22x)｜

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## 401—

名称｜类别｜分子式｜Ki/nM (CB1)｜Ki/nM (CB2)｜选择性｜结构｜CAS编号

JWH-412｜萘甲酰基吲哚｜C24H22FNO

JWH-416｜萘甲酰基吲哚｜C24H22INO｜73 ± 10｜3.3 ± 0.1｜CB2 (22x)｜

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JWH-417｜萘甲酰基吲哚｜C25H24INO｜522 ± 58｜13 ± 0.2｜CB2 (40x)｜

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JWH-422｜萘甲酰基吲哚｜C23H20INO｜501 ± 48｜20 ± 0.4｜CB2 (25x)｜

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JWH-423｜萘甲酰基吲哚｜C22H18INO｜140 ± 10｜6.6 ± 0.2｜CB2 (21x)｜

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JWH-424｜萘甲酰基吲哚｜C24H22BrNO｜21 ± 3.4｜5.4 ± 0.2｜CB2 (3.9x)｜

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JWH-425｜萘甲酰基吲哚｜C25H24BrNO｜54 ± 11｜10 ± 0.4｜CB2 (5.4x)｜

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