SOCS3

细胞因子信号传导抑制因子3(SOCS3或 SOCS-3)是一种在人体内由 SOCS3基因编码的蛋白。该基因编码 STAT- 诱导的 STAT 抑制子(SSI)，也可称为细胞因子信号转导(SOCS)家族抑制子，的一个成员。SSI 家族成员是可由细胞因子诱导的细胞因子信号转导负调节因子。

## 功能

SOCS3基因的表达可由多种细胞因子的诱导，包括 IL-6，IL-10，干扰素-γ(IFN-γ)。

在 IL-6，Epo，GCSF 和瘦素的信号传导中，已发现SOCS3在各自的细胞因子受体上的结合对 SOCS3的抑制功能而言是至关重要的。

SOCS3的过表达会抑制脂肪组织和肝脏胰岛素信号转导，但对肌肉则不然。但是在小鼠骨骼肌中敲除 SOCS3可以保护小鼠免于肥胖相关的胰岛素抵抗。

由于神经酰胺合成的增加，SOCS3会增加瘦素抵抗和胰岛素抵抗。因此，研究已表明去除 SOCS 基因可以预防肥胖症患者的胰岛素抵抗

对该小鼠中基因的同源基因的研究表明，该基因在胎儿肝脏造血和胎盘发育的负调控中发挥作用。

SOCS3蛋白能与JAK2结合，抑制其活性。

## 相互作用

已经证明 SOCS3可以与下列物质相互作用:

- 促红细胞生成素受体
- 糖蛋白130
- 胰岛素样生长因子1受体
- JAK2
- PTPN11
- RAS p21蛋白激活因子1

## 调控

有部分证据表明 SOCS3的表达受小分子核糖核酸 miR-203的调控。

## 扩展阅读

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