王陆海

王陆海（1947年），台湾分子生物学家与肿瘤学家。

## 生平

出生于台湾，曾为美国西奈山医学中心微生物学、癌症中心、肿瘤科学系正教授，回台湾进入国家卫生研究院 (代理院长)、中央研究院院士，2012年当选TWAS (The Academy of Sciences for the developing world, TWAS发展中世界科学院)院士。主要研究癌症防治、肿瘤学、分子生物学。现为中国医药大学副校长暨中医学院中西医结合研究所讲座教授，国立台湾大学分子与细胞生物学研究所、国立中央大学生命科学系与清华大学兼任教授，同时也是美国华阳生命科学股份有限公司 (Sun Farm Corp.) 科学委员、亿康生物科技股份有限公司董事。

## 专业

- 癌症生物学 (Cancer Biology)
- 分子生物学 (Molecular biology)
- 华阳复方( Selected Vegetables,SV)
- 赫保康( HBK )

## 研究团队

- 孙士銧
- 孙达士
- 杨思标
- 林瑞雄
- 毛仁淡
- Henry sacks
- Thomas M. Fasy

## 著作

- 1.Sachdev, P., Zeng, L. and Wang, L.-H. (2002). Distinct role of hosphotidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. J. Biol. Chem. 277:17638-17648.
- 2.Le, Maithao N., Kohanski, Ronald.A., Wang, Lu-Hai and Sadowski, Henry (2002). Dual mechanism of signal transduccer and activator of transcription 5 (Stat5) activation by the insulin receptor. Molecular Endocrinology 16:2764-2779.
- 3.Uttamsingh, Shailaja, Zong, Cong S. and Wang, Lu-Hai (2003). Matrix-independent activation of PI3 kinase, Stat3 and cyclin A-associated Cdk2 is essential for anchorage independent growth of v-Ros transformed chicken embryo fibroblasts. J. Biol. Chem. 278:18798-18810.
- 4.Wang, Lu-Hai (2004) Molecular signaling regulating anchorage-independent growth of cancer cells. The Mount Sinai J. of Medicine 71:361-367.
- 5.Lopewz-Bergami, P., Hasen H., Bhoumik, A, Zhang, W., Wang L.-H., and Ronai, Z. (2005) Receptor for RACK1 mediates activation of JNK by protein kinase C. Mol. Cell 19:309-320.
- 6.Zhang, W., Zong, C. S., Hermanto, U., Lopez-Bergami, P., Ronai, Z. and Wang, L.-H. (2005) RACK1 recruits STAT3 specifically to insulin and IGF-1 receptors for activation, which is important for regulating anchorage independent growth. Mol. Cell Biol. 26:413-424.
- 7.Yio, X., Diamond, M., Zhang, J.-Y., Weinstein, H., Wang, L.-H., Werther, L. and Itzkowitz, S. (2006) Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways. Gastroenterology 130:1696-706.
- 8.Dong, Z., Liu, Y., Lu, S., Wang, A., Lee, K., Wang, L.-H., Revdo, M. and Lu, S. (2006) Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Mol Endo. 20:2315-2325.
- 9.Cheng, G. Z., Chan, J., Sun, C.D., Wang, Q., Zhang, W. and Wang, L.-H. (2007). Twist transcriptionally upregulates AKT2 in invasive breast cancer cells leading to increased migration and survival. Cancer Research 67:1979-87.
- 10.Wang, L.-H., Chan, J. L.-K. and Li, W. (2007) Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells. Intl. J. Cancer 157-164.
- 11.K Masker, A. Golden, C. J. Gaffney, V. Mazack, W. F. Schwindinger, W. Zhang, L.-H. Wang, D.J. Carey and M. Sudol (2007). Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral src. Virology 364:10-20.
- 12.Cheng G Z, Zhang W, Wang L.-H. (2008) Regulation of cancer cell survival, migration and invasion by Twist: AKT2 comes to interplay. Cancer Research 68:957-960.
- 13.Uttamsingh, S, Bao, X., Nguyen, K. T., Bhanot M., Chan J. L.-K., Liu F, Chu T. and Wang, L-H. (2008) Synergistic effect between EGF and TGF-1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27:2626-2634.
- 14.Cheng G Z, Zhang W, Sun M, Wang, Q, Coppola D, Costanzo C, Xu L M, Chan J, Cheng J Q, Wang L-H. (2008) Twist is Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. JBC 283:14665-73.
- 15.Cheng G. Z., Park S., Shu S., He L., Kong W., Zhang W., Yuan Z., Wang L.-H., Cheng J. Q. (2008) Advances of AKT pathway in human oncogenesis and as a target for anti- cancer drug discovery. Current Cancer Drug Targets 8:2-6.
- 16.Wang, L.-H. (2008) Overview of modular domains and adaptor proteins, pp1-32 in “Adaptor proteins and cancer” Ed. M. Georges, Transworld Research Network, Trivandrum-695 023, Kerala, India.
- 17.Zhang W., Cheng G. Z., Hermanto U., Zong C. S., Chan J., Cheng J. and Wang, L.-H. (2008) RACK1 and CIS mediate the degradation of BimEL in cancer cells. JBC 283:16416-26.
- 18.Schlosshauer, P.W., Li, W., Lin, Kai-Ti., Chan, J. L-K. and Wang, L.-H. (2009) Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells. Gynecologic Oncology 114:516-522.
- 19.Jiang SS, Fang WT, Hou YH, Huang SF, Yen BL, Chang JL, Li SM, Liu HP, Liu YL, Huang CT, Li YW, Jang TH, Chan SH, Yang SJ, Hsiung CA, Wu CW, Wang LH, Chang IS. Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res. 2010 Sep 1;16(17):4363-73. doi: 10.1158/1078-0432.CCR-10-0138. Epub 2010 Jul 22
- 20.Tsai YC, Pestka S, Wang LH, Runnels L W, Wan S, Lyu YL and Liu L F. (2011) Interferon-β Autocrine Signaling Promotes Oncogenic Ras-Induced Cell Transformation. PLoS ONE 6(8): e24291, 1-8.
- 21.Lin, K.T. , Gong, J, Jang, T. H., Chen, H. J., Li, J. F. and Wang, L-H. (2012) EphA2-Vav3-Rac1 signaling mediates migratory and invasive behavior of prostate cancer cells and correlates with the disease progression Cancer Research 72 (12):3000-3009.
- 22.Lin, K.-Y, Wang, L-H., Hsen, Y. -C., Fung, C. -L., Yang, H. -L., Senthil Kumar, K.J., Tai, C. and Uen, Y.-H. (2012) Clinical significance of creased guanine nucleotide exchange factor Vav3 expression in human gastric cancer. Molecular Cancer Research 10(6): 750-759.
- 23.HJ Shih, HH Chen, YA Chen, MH Wu, GG Liou, WW Chang, LY Chen, LH Wang, HL Hsu. Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity. Oncotarget. 2012 Nov;3(11):1401-1415.
- 24.Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL. The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities. Cell Cycle. 2012 Mar 1;11(5):934-952
- 25.Yeh YM, Chuang CM, Chao KC, Wang LH. (2013) MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1α. Int J Cancer. Aug 15;133(4):867-78.
- 26.Huang WC, Chan SH, Jang TH, Chang JW, Ko YC, Yen TC, Chiang SL, Chiang WF, Shieh TY, Liao CT, Juang JL, Wang HC, Cheng AJ, Lu YC, Wang LH. (2014) miRNA-491-5p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis. Cancer Res. Feb 1;74(3):751-64.
- 27.Chan SH, Huang WC, Chang JW, Chang KJ, Kuo WH, Wang MY, Lin KY, Uen YH, Hou MF, Lin CM, Jang TH, Tu CW, Lee YR, Lee YH, Tien MT, Wang LH. (2014) MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis. Oncogene. Sep 4;33(36):4496-507
- 28.Lin KT, Yeh YM, Chuang CM, Yang SY, Chang JW, Sun SP, Wang YS, Chao KC, Wang LH. (2015) Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. Nat Commun. Jan 8;6:5917.
- 29.Chan SH, Wang LH. (2015) Regulation of cancer metastasis by microRNAs. J Biomed Sci. Jan 23;22:9.

## 基本资料

- 性别：男
- 出生地：中华民国台湾省台南县斗六区斗南镇
- 国籍：中华民国
- 学历：云林县斗南国民学校、台湾省立嘉义中学、国立台湾大学动物学系、美国加州大学柏克莱分校分子生物学博士
- past：美国洛克菲勒大学博士后研究员、（1977年－1979年）、美国洛克菲勒大学助理教授（1979年－1985年）、美国西奈山医学院微生物学副教授、（1985年－1988年）、美国国立卫生研究院研究员、（1986年－1992年）、美国西奈山医学院微生物学终身教职副教授、（1988年－1992年）、美国卫生研究院考研审稿储备、（1992年－）、美国西奈山医学院微生物学、肿瘤学科学教授、（1992年-）、美国西奈山医学院癌症中心教授、（1999年-2004年）、台湾国家卫生研究院特聘研究员兼主任、讲座教授（2008年-）、台湾国家卫生研究院特聘研究员、专案讲座教授（2017年-）、台湾中国医药大学副校长暨中西结合研究所教授、讲座教授（2017年-）
- 组别：生命科学组
- 届数：第28届
- 当选年：2010年