克萊門森大學的約翰威廉霍夫曼（John William Huffman）研究小組合成了 450 多種大麻素。其中一些是： 001100 大麻素及其 Ki 值 名稱 類別 分子式 KinM CB1 KinM CB2 選擇性 結構 CAS 編號 JWH004 萘甲醯基吲哚 C26H27NO 48 13 4 15 CB2 12x JWH007 萘甲醯基吲哚 C25H25NO 95 45 29 26 CB2 33x JWH009 萘甲醯基吲哚 C27H29NO 10000 141 14 CB2 70x JWH011 萘甲醯基吲哚 C27H29NO JWH015 萘甲醯基吲哚 C23H21NO 164 22 138 46 CB2 12x JWH016 萘甲醯基吲哚 C24H23NO 22 15 43 16 CB2 51x JWH018 萘甲醯基吲哚 C24H23NO 9 5 29 26 CB2 31x JWH019 萘甲醯基吲哚 C25H25NO 98 2 555 2 CB2 177x JWH020 萘甲醯基吲哚 C26H27NO 128 17 205 20 CB1 16x JWH030 萘甲醯基吡咯 C20H21NO 87 3 320 127 CB1 37x JWH031 萘甲醯基吡咯 C21H23NO 399 109 JWH032 萘甲醯基吡咯 C18H17NO 10000 10000 JWH033 萘甲醯基吡咯 C19H19NO 666 77 JWH036 萘甲醯基吡咯 C22H25NO 309 11 JWH042 萘甲醯基吲哚 C21H17NO 10000 5050 192 CB2 JWH043 萘甲醯基吲哚 C22H19NO 1180 44 964 242 CB2 12x JWH044 萘甲醯基吡咯 C16H13NO 10000 10000 JWH045 萘甲醯基吡咯 C17H15NO 10000 10000 JWH046 萘甲醯基吲哚 C24H23NO 343 38 163 49 CB2 21x JWH047 萘甲醯基吲哚 C25H25NO 59 3 347 180 CB2 17x JWH048 萘甲醯基吲哚 C26H27NO 107 10 049 013 CB2 22x JWH049 萘甲醯基吲哚 C27H29NO 551 170 323 24 CB2 17x JWH050 萘甲醯基吲哚 C28H31NO 342 6 526 133 CB1 15x JWH051 二苯並吡喃 C25H38O2 120 003 CB2 40x JWH056 二苯並吡喃 C21H30O 10000 32 9 CB2 JWH057 二苯並吡喃 C25H38O 23 7 29 16 CB2 8x JWH065 二苯並吡喃 C23H34O 399 76 10 2 CB2 40x JWH070 萘甲醯基吲哚 C20H15NO 10000 10000 JWH071 萘甲醯基吲哚 C21H17NO 1340 123 2940 852 CB1 22x JWH072 萘甲醯基吲哚 C22H19NO 1050 55 170 54 CB2 6x JWH073 萘甲醯基吲哚 C23H21NO 89 18 27 12 CB1 3x JWH076 萘甲醯基吲哚 C23H21NO 214 11 106 46 CB2 2x JWH077 萘甲醯基吲哚 C21H17NO2 10000 10000 JWH078 萘甲醯基吲哚 C22H19NO2 817 60 633 116 CB2 13x JWH079 萘甲醯基吲哚 C23H21NO2 630 30 320 60 CB2 2x JWH080 萘甲醯基吲哚 C24H23NO2 89 18 221 130 CB2 4x JWH081 萘甲醯基吲哚 C25H25NO2 12 003 124 22 CB1 10x JWH082 萘甲醯基吲哚 C26H27NO2 53 08 640 094 CB1 12x JWH083 萘甲醯基吲哚 C27H29NO2 106 12 102 50 JWH091Bow EW Rimoldi JM The StructureFunction Relationships of Classical Cannabinoids CB1CB2 Modulation Perspect Medicin Chem 2016 Jun 2881739 Δ8THCP 二苯並吡喃 C23H34O2 220 39 JWH093 萘甲醯基吲哚 C27H29NO2 407 28 591 105 CB1 145x JWH094 萘甲醯基吲哚 C24H23NO2 476 67 973 27 CB2 49x JWH095 萘甲醯基吲哚 C29H33NO2 140 43 312 83 CB1 22x JWH096 萘甲醯基吲哚 C25H25NO2 337 29 133 56 CB2 25x JWH097 萘甲醯基吲哚 C31H37NO2 455 28 121 15 CB2 38x JWH098 萘甲醯基吲哚 C26H27NO2 45 01 19 03 CB2 24x JWH099 萘甲醯基吲哚 C27H29NO2 353 90 178 29 CB2 2x JWH100 萘甲醯基吲哚 C28H31NO2 381 102 155 74 CB2 25x 101200 大麻素及其 Ki 值 名稱 類別 分子式 KinM CB1 KinM CB2 選擇性 結構 CAS 編號 JWH102 二苯並吡喃 C24H38O2 79 09 52 20 CB2 15x JWH103 二苯並吡喃 C24H38O2 28 3 23 7 CB2 12x JWH116 萘甲醯基吲哚 C26H27NO 52 5 JWH120 萘甲醯基吲哚 C23H21NO 1054 31 61 07 CB2 173x 萘甲醯基吲哚 C24H23NO JWH122 萘甲醯基吲哚 C25H25NO 069 005 12 12 JWH124 Δ8Parahexyl 二苯並吡喃 C22H32O2 410 38 JWH130 Δ8THCB 二苯並吡喃 C20H28O2 650 13 JWH133 二苯並吡喃 C22H32O 677 132 34 10 CB2 200x JWH138Martin BR Jefferson R Winckler R Wiley JL Huffman JW Crocker PJ Saha B Razdan RK Manipulation of the tetrahydrocannabinol side chain delineates agonists partial agonists and antagonists J Pharmacol Exp Ther 1999 Sep290 3106579 二苯並吡喃 C24H36O2 85 14 JWH139 二苯並吡喃 C21H30O 2290 505 14 10 CB2 164x JWH142 二苯並吡喃 C26H40O2 529 49 35 14 CB2 15x JWH143 二苯並吡喃 C26H40O2 924 104 65 8 CB2 14x JWH145 萘甲醯基吡咯 C26H25NO 14 2 64 04 CB2 22x JWH146 萘甲醯基吡咯 C28H29NO 21 2 62 5 CB2 30x JWH147 萘甲醯基吡咯 C27H27NO 11 1 71 02 CB2 15x JWH148 萘甲醯基吲哚 C24H23NO 123 8 140 10 CB2 8x JWH149 萘甲醯基吲哚 C26H27NO 50 21 073 003 CB2 68x JWH150 萘甲醯基吡咯 C25H23NO 60 1 15 2 CB2 4x JWH151 萘甲醯基吲哚 C24H23NO2 10000 30 11 CB2 333x JWH153 萘甲醯基吲哚 C26H27NO2 250 24 11 05 CB2 23x JWH156 萘甲醯基吡咯 C24H21NO 404 18 104 18 CB2 4x JWH159 萘甲醯基吲哚 C26H27NO2 45 1 104 14 CB2 43x JWH160 萘甲醯基吲哚 C24H23NO2 1568 201 441 110 CB2 36x JWH161 二苯並吡喃 C27H33NO2 190 JWH163 萘甲醯基吲哚 C23H21NO2 2358 215 138 12 CB2 17x JWH164 萘甲醯基吲哚 C25H25NO2 66 07 69 02 JWH165 萘甲醯基吲哚 C23H21NO2 204 26 71 8 CB2 29x JWH166 萘甲醯基吲哚 C25H25NO2 44 10 19 008 CB2 23x JWH167 苯乙醯吲哚 C21H23NO 90 17 159 14 CB1 177x JWH171 碳氫 C25H24 51 JWH175 萘甲基吲哚 C24H25N 22 2 JWH176 碳氫 C25H24 26 4 JWH180 萘甲醯基吲哚 C25H25NO 26 2 96 20 CB2 27x JWH181 萘甲醯基吲哚 C28H31NO 13 01 062 004 CB2 21x JWH182 萘甲醯基吲哚 C27H29NO 065 003 11 01 CB1 17x JWH184 萘甲基吲哚 C25H27N 23 6 JWH185 萘甲基吲哚 C25H27NO 17 3 JWH186 二苯並吡喃 C21H30O2 187 23 56 17 CB2 33x JWH187 二苯並吡喃 C22H32O2 84 16 34 05 CB2 25x JWH188 二苯並吡喃 C20H28O2 270 58 18 2 CB2 15x JWH189 萘甲醯基吲哚 C26H27NO 52 2 12 08 CB2 43x JWH190 二苯並吡喃 C23H34O2 88 14 16 003 CB2 55x JWH191 二苯並吡喃 C24H36O2 18 03 052 003 CB2 35x JWH192 萘甲基吲哚 C26H28N2O 41 13 JWH193 萘甲醯基吲哚 C26H26N2O2 6 1 JWH194 萘甲基吲哚 C26H29N 127 19 JWH195 萘甲基吲哚 C25H26N2O 113 28 JWH196 萘甲基吲哚 C25H27N 151 18 JWH197 萘甲基吲哚 C26H29NO 323 98 JWH198 萘甲醯基吲哚 C26H26N2O3 10 2 JWH199 萘甲基吲哚 C26H28N2O2 20 2 JWH200 萘甲醯基吲哚 C25H24N2O2 42 5 201300 大麻素及其 Ki 值 名稱 類別 分子式 KinM CB1 KinM CB2 選擇性 結構 CAS 編號 JWH201 苯乙醯吲哚 C22H25NO2 1064 21 444 14 CB2 24x JWH202 苯乙醯吲哚 C23H27NO2 1678 63 645 6 CB2 26x JWH203 苯乙醯吲哚 C21H22ClNO 80 09 70 13 JWH204 苯乙醯吲哚 C22H24ClNO 13 1 25 1 CB1 19x JWH205 苯乙醯吲哚 C22H25NO 124 23 180 9 CB1 145x JWH206 苯乙醯吲哚 C21H22ClNO 389 25 498 37 CB1 128x JWH207 苯乙醯吲哚 C22H24ClNO 1598 134 3723 10 CB1 233x JWH208 苯乙醯吲哚 C22H25NO 179 7 570 127 CB1 318x JWH209 苯乙醯吲哚 C23H27NO 746 49 1353 270 CB1 181x JWH210 萘甲醯基吲哚 C26H27NO 046 003 069 001 CB1 15x JWH211 萘甲醯基吲哚 C25H25NO 70 08 12 08 CB2 58x JWH212 萘甲醯基吲哚 C24H23NO 33 09 10 12 CB2 33x JWH213 萘甲醯基吲哚 C27H29NO 15 02 042 005 CB2 36x JWH215 二苯並吡喃 C22H32O3 1008 117 85 21 CB2 12x JWH216 二苯並吡喃 C21H30O3 1856 148 333 104 CB2 56x JWH217 二苯並吡喃 C22H32O2 10000 1404 66 CB2 7x JWH220 碳氫 C26H26 19 JWH224 二苯並吡喃 C23H34O3 347 34 28 1 CB2 123x JWH225 二苯並吡喃 C23H34O2 10000 325 70 CB2 31x JWH226 二苯並吡喃 C24H36O2 4001 282 43 3 CB2 93x JWH227 二苯並吡喃 C24H36O3 40 6 44 03 CB2 9x JWH229 二苯並吡喃 C25H38O2 3134 110 18 2 CB2 174x JWH230 二苯並吡喃 C25H38O3 15 3 14 012 CB2 107x JWH233 二苯並吡喃 C26H40O3 14 3 10 03 CB2 14x （6aR10aR）（6aS10aS） JWH234 萘甲醯基吲哚 C26H27NO 84 18 38 06 CB2 22x JWH235 萘甲醯基吲哚 C24H23NO 338 34 123 34 CB2 27x JWH236 萘甲醯基吲哚 C25H25NO 1351 204 240 63 CB2 56x JWH237 苯乙醯吲哚 C21H22ClNO 38 10 106 2 CB1 28x JWH239 萘甲醯基吲哚 C26H27NO 342 20 52 6 CB2 66x JWH240 萘甲醯基吲哚 C28H31NO 14 1 72 13 CB2 19x JWH241 萘甲醯基吲哚 C27H29NO 147 20 49 7 CB2 30x JWH242 萘甲醯基吲哚 C29H33NO 42 9 65 03 CB2 65x JWH243 萘甲醯基吡咯 C27H27NO2 285 40 41 3 CB2 695x JWH244 萘甲醯基吡咯 C27H27NO 130 6 18 1 CB2 722x JWH245 萘甲醯基吡咯 C26H24ClNO 276 4 25 2 CB2 11x JWH246 萘甲醯基吡咯 C26H24ClNO 70 4 16 1 CB2 438x JWH247 二苯並吡喃 C25H38O2 427 31 99 4 CB2 43x JWH248 苯乙醯吲哚 C21H22BrNO 1028 39 657 19 CB2 156x JWH249 苯乙醯吲哚 C21H22BrNO 84 18 20 2 CB1 238x JWH250 苯乙醯吲哚 C22H25NO2 11 2 33 2 CB1 3x JWH251 苯乙醯吲哚 C22H25NO 29 3 146 36 CB2 5x JWH252 苯乙醯吲哚 C23H27NO 23 3 19 1 CB2 12x JWH253 苯乙醯吲哚 C23H27NO2 62 10 84 12 CB1 135x JWH254 二苯並吡喃 C23H34O2 4724 509 319 16 CB2 148x JWH256 二苯並吡喃 C24H36O2 4300 888 97 18 CB2 44x JWH258 萘甲醯基吲哚 C26H27NO2 46 06 105 13 CB1 23x JWH259 萘甲醯基吲哚 C24H23NO2 220 29 74 7 CB2 30x JWH260 萘甲醯基吲哚 C27H29NO2 29 04 25 19 CB2 12x JWH261 萘甲醯基吲哚 C25H25NO2 767 105 221 14 CB2 35x JWH262 萘甲醯基吲哚 C27H29NO 28 3 56 07 CB2 50x JWH265 萘甲醯基吲哚 C23H21NO2 3788 323 80 13 CB2 47x JWH266 萘甲醯基吲哚 C24H23NO2 10000 455 55 CB2 22x JWH267 萘甲醯基吲哚 C25H25NO2 381 16 72 014 CB2 53x JWH268 萘甲醯基吲哚 C26H27NO2 1379 193 40 06 CB2 34x JWH277 二苯並吡喃 C22H34O3 3905 91 589 65 CB2 66x JWH278 二苯並吡喃 C23H36O3 906 80 69 6 CB2 13x JWH292 萘甲醯基吡咯 C27H27NO2 29 1 20 1 CB2 145x JWH293 萘甲醯基吡咯 C26H24N2O3 100 5 41 4 CB2 244x JWH298 二苯並吡喃 C22H34O3 812 67 198 23 CB2 41x JWH299 二苯並吡喃 C23H36O3 415 50 30 2 CB2 138x JWH300 二苯並吡喃 C22H34O2 118 16 53 01 CB2 22x 301400 大麻素及其 Ki 值 名稱 類別 分子式 KinM CB1 KinM CB2 選擇性 結構 CAS 編號 JWH301 二苯並吡喃 C22H34O2 295 64 48 4 CB2 61x JWH302 苯乙醯吲哚 C22H25NO2 17 2 89 15 CB1 526x JWH303 苯乙醯吲哚 C22H24ClNO 117 10 138 12 CB1 118x JWH304 苯乙醯吲哚 C22H24BrNO 3363 332 2679 688 CB2 126x JWH305 苯乙醯吲哚 C22H24BrNO 15 18 29 5 CB1 193x JWH306 苯乙醯吲哚 C23H27NO2 25 1 82 11 CB1 328x JWH307 萘甲醯基吡咯 C26H24FNO 77 18 33 02 CB2 233x JWH308 萘甲醯基吡咯 C26H24FNO 41 1 33 2 CB2 124x JWH309 萘甲醯基吡咯 C30H27NO 41 3 49 7 CB1 120x JWH310 二苯並吡喃 C21H32O2 1059 51 36 3 CB2 29x JWH311 苯乙醯吲哚 C21H22FNO 23 2 39 3 CB1 170x JWH312 苯乙醯吲哚 C21H22FNO 72 7 91 20 CB1 126x JWH313 苯乙醯吲哚 C21H22FNO 422 19 365 92 CB2 116x JWH314 苯乙醯吲哚 C22H24FNO 39 2 76 4 CB1 195x JWH315 苯乙醯吲哚 C22H24FNO 430 24 182 23 CB2 336x JWH316 苯乙醯吲哚 C22H24FNO 2862 670 781 105 CB2 366x JWH336 二苯並吡喃 C21H32O2 4589 367 153 15 CB2 30x JWH338 二苯並吡喃 C20H28O 10000 111 16 CB2 90x JWH339 二苯並吡喃 C21H30O2 10000 2317 93 CB2 43x JWH340 二苯並吡喃 C25H40O3 135 6 30 1 CB2 45x JWH341 二苯並吡喃 C25H40O3 100 8 10 01 CB2 10x JWH346 萘甲醯基吡咯 C27H27NO 67 6 39 2 CB2 172x JWH347 萘甲醯基吡咯 C30H27NO 333 17 169 17 CB2 197x JWH348 萘甲醯基吡咯 C27H24F3NO 218 19 53 1 CB2 411x JWH349 二苯並吡喃 C24H38O3 376 1 38 4 CB2 99x JWH350 二苯並吡喃 C24H38O3 395 50 12 1 CB2 33x JWH351 二苯並吡喃 C22H32O2 10000 295 3 CB2 34x JWH352 二苯並吡喃 C21H30O 10000 47 2 CB2 213x JWH353 二苯並吡喃 C22H32O 1493 10 31 1 CB2 48x JWH354 二苯並吡喃 C23H34O2 1961 21 241 14 CB2 81x JWH355 二苯並吡喃 C23H34O 2162 220 108 17 CB2 20x JWH356 二苯並吡喃 C24H36O2 5837 701 108 17 CB2 54x JWH357 二苯並吡喃 C24H36O 647 78 185 4 CB2 35x JWH358 二苯並吡喃 C25H38O2 1243 266 52 3 CB2 24x JWH359 二苯並吡喃 C24H36O2 2918 450 130 02 CB2 220x JWH360 二苯並吡喃 C21H30O 2449 606 160 8 CB2 15x JWH361 二苯並吡喃 C23H36O2 63 3 27 01 CB2 23x JWH362 二苯並吡喃 C23H36O2 127 8 34 5 CB2 37x JWH363 萘甲醯基吡咯 C27H24F3NO 245 5 71 1 CB2 345x JWH364 萘甲醯基吡咯 C28H29NO 34 3 29 1 CB2 117x JWH365 萘甲醯基吡咯 C28H29NO 17 1 34 02 CB2 50x JWH366 萘甲醯基吡咯 C25H24N2O 191 12 24 1 CB2 796x JWH367 萘甲醯基吡咯 C27H27NO2 53 2 23 1 CB2 230x JWH368 萘甲醯基吡咯 C26H24FNO2 16 1 91 07 CB2 176x JWH369 萘甲醯基吡咯 C26H24ClNO2 79 04 52 03 CB2 152x JWH370 萘甲醯基吡咯 C27H27NO 56 04 40 05 CB2 140x JWH371 萘甲醯基吡咯 C30H33NO 42 1 64 2 CB1 152x JWH372 萘甲醯基吡咯 C27H24F3NO 77 2 82 02 CB1 939x JWH373 萘甲醯基吡咯 C30H33NO 60 3 69 2 CB1 115x JWH387 萘甲醯基吲哚 C24H22BrNO 12 01 11 01 JWH398 萘甲醯基吲哚 C24H22ClNO 23 01 28 02 CB1 122x 401 大麻素及其 Ki 值 名稱 類別 分子式 KinM CB1 KinM CB2 選擇性 結構 CAS 編號 JWH416 萘甲醯基吲哚 C24H22INO 73 10 33 01 CB2 22x JWH417 萘甲醯基吲哚 C25H24INO 522 58 13 02 CB2 40x JWH422 萘甲醯基吲哚 C23H20INO 501 48 20 04 CB2 25x JWH423 萘甲醯基吲哚 C22H18INO 140 10 66 02 CB2 21x JWH424 萘甲醯基吲哚 C24H22BrNO 21 34 54 02 CB2 39x JWH425 萘甲醯基吲哚 C25H24BrNO 54 11 10 04 CB2 54x 參見 AM 大麻素列表 CP 大麻素列表 HU 大麻素列表 註釋 參考資料 Category 大麻素