王陸海，臺灣分子生物學家和腫瘤學家。 生平 出生於臺灣，曾為美國西奈山醫學中心微生物學、癌症中心、腫瘤科學系正教授，回臺灣進入國家衛生研究院 代理院長、中央研究院院士，2012 年當選 TWAS The Academy of Sciences for the developing world TWAS 發展中世界科學院 院士。主要研究癌症防治、腫瘤學、分子生物學。現為中國醫藥大學副校長暨中醫學院中西醫結合研究所講座教授，國立臺灣大學分子與細胞生物學研究所、國立中央大學生命科學系與清華大學兼任教授，同時也是美國華陽生命科學股份有限公司 Sun Farm Corp 科學委員、億康生物科技股份有限公司董事。 專業 癌症生物學 Cancer Biology 分子生物學 Molecular biology 華陽複方 Selected VegetablesSV 赫保康 HBK 研究團隊 孫士銧 孫達士 楊思標 林瑞雄 毛仁淡 Henry sacks Thomas M Fasy 著作 1Sachdev P Zeng L and Wang LH 2002 Distinct role of hosphotidylinositol 3kinase and Rho family GTPases in Vav3induced cell transformation cell motility and morphological changes J Biol Chem 2771763817648 2Le Maithao N Kohanski RonaldA Wang LuHai and Sadowski Henry 2002 Dual mechanism of signal transduccer and activator of transcription 5 Stat5 activation by the insulin receptor Molecular Endocrinology 1627642779 3Uttamsingh Shailaja Zong Cong S and Wang LuHai 2003 Matrixindependent activation of PI3 kinase Stat3 and cyclin Aassociated Cdk2 is essential for anchorage independent growth of vRos transformed chicken embryo fibroblasts J Biol Chem 2781879818810 4Wang LuHai 2004 Molecular signaling regulating anchorageindependent growth of cancer cells The Mount Sinai J of Medicine 71361367 5LopewzBergami P Hasen H Bhoumik A Zhang W Wang LH and Ronai Z 2005 Receptor for RACK1 mediates activation of JNK by protein kinase C Mol Cell 19309320 6Zhang W Zong C S Hermanto U LopezBergami P Ronai Z and Wang LH 2005 RACK1 recruits STAT3 specifically to insulin and IGF1 receptors for activation which is important for regulating anchorage independent growth Mol Cell Biol 26413424 7Yio X Diamond M Zhang JY Weinstein H Wang LH Werther L and Itzkowitz S 2006 Trefoil factor family1 mutations enhance gastric cancer cell invasion through distinct signaling pathways Gastroenterology 1301696706 8Dong Z Liu Y Lu S Wang A Lee K Wang LH Revdo M and Lu S 2006 Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer Mol Endo 2023152325 9Cheng G Z Chan J Sun CD Wang Q Zhang W and Wang LH 2007 Twist transcriptionally upregulates AKT2 in invasive breast cancer cells leading to increased migration and survival Cancer Research 67197987 10Wang LH Chan J LK and Li W 2007 Rapamycin together with herceptin significantly increased antitumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells Intl J Cancer 157164 11K Masker A Golden C J Gaffney V Mazack W F Schwindinger W Zhang LH Wang DJ Carey and M Sudol 2007 Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral src Virology 3641020 12Cheng G Z Zhang W Wang LH 2008 Regulation of cancer cell survival migration and invasion by Twist AKT2 comes to interplay Cancer Research 68957960 13Uttamsingh S Bao X Nguyen K T Bhanot M Chan J LK Liu F Chu T and Wang LH 2008 Synergistic effect between EGF and TGF1 in inducing oncogenic properties of intestinal epithelial cells Oncogene 2726262634 14Cheng G Z Zhang W Sun M Wang Q Coppola D Costanzo C Xu L M Chan J Cheng J Q Wang LH 2008 Twist is Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function JBC 2831466573 15Cheng G Z Park S Shu S He L Kong W Zhang W Yuan Z Wang LH Cheng J Q 2008 Advances of AKT pathway in human oncogenesis and as a target for anti cancer drug discovery Current Cancer Drug Targets 826 16Wang LH 2008 Overview of modular domains and adaptor proteins pp132 in Adaptor proteins and cancer Ed M Georges Transworld Research Network Trivandrum695 023 Kerala India 17Zhang W Cheng G Z Hermanto U Zong C S Chan J Cheng J and Wang LH 2008 RACK1 and CIS mediate the degradation of BimEL in cancer cells JBC 2831641626 18Schlosshauer PW Li W Lin KaiTi Chan J LK and Wang LH 2009 Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells Gynecologic Oncology 114516522 19Jiang SS Fang WT Hou YH Huang SF Yen BL Chang JL Li SM Liu HP Liu YL Huang CT Li YW Jang TH Chan SH Yang SJ Hsiung CA Wu CW Wang LH Chang IS Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity Clin Cancer Res 2010 Sep 116 17436373 doi 10115810780432CCR100138 Epub 2010 Jul 22 20Tsai YC Pestka S Wang LH Runnels L W Wan S Lyu YL and Liu L F 2011 Interferonβ Autocrine Signaling Promotes Oncogenic RasInduced Cell Transformation PLoS ONE 6 8 e24291 18 21Lin KT Gong J Jang T H Chen H J Li J F and Wang LH 2012 EphA2Vav3Rac1 signaling mediates migratory and invasive behavior of prostate cancer cells and correlates with the disease progression Cancer Research 72 1230003009 22Lin KY Wang LH Hsen Y C Fung C L Yang H L Senthil Kumar KJ Tai C and Uen YH 2012 Clinical significance of creased guanine nucleotide exchange factor Vav3 expression in human gastric cancer Molecular Cancer Research 10 6 750759 23HJ Shih HH Chen YA Chen MH Wu GG Liou WW Chang LY Chen LH Wang HL Hsu Targeting MCT1 oncogene inhibits Shc pathway and xenograft tumorigenicity Oncotarget 2012 Nov3 1114011415 24Shih HJ Chu KL Wu MH Wu PH Chang WW Chu JS Wang LH Takeuchi H Ouchi T Hsu HL The involvement of MCT1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities Cell Cycle 2012 Mar 111 5934952 25Yeh YM Chuang CM Chao KC Wang LH 2013 MicroRNA138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF1α Int J Cancer Aug 15133 486778 26Huang WC Chan SH Jang TH Chang JW Ko YC Yen TC Chiang SL Chiang WF Shieh TY Liao CT Juang JL Wang HC Cheng AJ Lu YC Wang LH 2014 miRNA4915p and GIT1 serve as modulators and biomarkers for oral squamous cell carcinoma invasion and metastasis Cancer Res Feb 174 375164 27Chan SH Huang WC Chang JW Chang KJ Kuo WH Wang MY Lin KY Uen YH Hou MF Lin CM Jang TH Tu CW Lee YR Lee YH Tien MT Wang LH 2014 MicroRNA149 targets GIT1 to suppress integrin signaling and breast cancer metastasis Oncogene Sep 433 364496507 28Lin KT Yeh YM Chuang CM Yang SY Chang JW Sun SP Wang YS Chao KC Wang LH 2015 Glucocorticoids mediate induction of microRNA708 to suppress ovarian cancer metastasis through targeting Rap1B Nat Commun Jan 865917 29Chan SH Wang LH 2015 Regulation of cancer metastasis by microRNAs J Biomed Sci Jan 23229 參考資料 國家衛生研究院王陸海主頁 國家衛生研究院王陸海院士 TWAS 當選新聞稿 植物複方治肺腺癌 進入第三期人體實驗 本院宣佈第 28 屆新任院士名單 外部連結 國家衛生研究院 中央研究院 中草藥資料庫 Category 臺灣裔美國科學家 Category 臺灣生物學家 Category 中央研究院生命科學組院士 L Category 國家衛生研究院院長 Category 中國醫藥大學教授 Category 美國腫瘤學家 Category 臺灣腫瘤學家 Category 加州大學柏克萊分校校友 Category 國立臺灣大學生物資源暨農學院校友 Category 斗南鎮人 Category 臺灣省立嘉義中學校友