荻野周史（，），主要從事病理學，流行病學和分子病理流行病學研究。目前在哈佛醫學院，布萊根婦女醫院和丹娜法伯癌症研究院及哈佛陳曾熙公共衛生學院擔任教授。荻野首次提出（MPE）這一學科概念，該學科是分子病理學和流行病學的交叉學科。 生平 於 1993 年獲得東京大學醫學院學士學位，於 19941995 年在沖繩美國海軍醫院實習，隨後赴美，並分別在卓克索大學阿勒格尼總醫院（19951997）及凱斯西儲大學 克利夫蘭大學醫院（19971999）完成病理解剖和臨床病理住院醫師培訓，19992000 年在賓夕法尼亞大學醫學中心進行分子病理學研究。2001 年獲得東京大學研究院醫學系博士學位後繼續在該中心從事博士後研究，20012004 在丹娜法伯癌症研究院，布萊根婦女醫院和哈佛醫學院擔任病理學講師，2004 年晉升為助理教授，2008 年晉升為副教授，2015 年晉升為丹娜法伯癌症研究院教授。繼 2011 年在哈佛陳曾熙公共衛生學院獲得流行病學碩士學位後，被任命為該學院的流行病學副教授，並 2015 年晉升為教授。 研究領域和成果 荻野於 2010 年首次提出 分子病理流行病學（MPE）Ogino S Stampfer M Lifestyle factors and microsatellite instability in colorectal cancer the evolving field of molecular pathological epidemiology J Natl Cancer Inst 2010102365367 這一概念。他認為將分子病理學研究帶入流行病學研究的框架是一個獨特的研究領域。此後，MPE 這一概念被廣泛採納 Curtin K Slattery ML Samowitz WS 2011 CpG island methylation in colorectal cancer past present and future Pathology Research International 2011 902674 doi1040612011902674 PMC 3090226 PMID 21559209Galon J Pagès F Marincola FM Angell HK Thurin M Lugli A Zlobec I Berger A Bifulco C Botti G Tatangelo F Britten CM Kreiter S Chouchane L Delrio P Arndt H Asslaber M Maio M Masucci GV Mihm M VidalVanaclocha F Allison JP Gnjatic S Hakansson L Huber C SinghJasuja H Ottensmeier C Zwierzina H Laghi L Grizzi F Ohashi PS Shaw PA Clarke BA Wouters BG Kawakami Y Hazama S Okuno K Wang E ODonnellTormey J Lagorce C Pawelec G Nishimura MI Hawkins R Lapointe R Lundqvist A Khleif SN Ogino S Gibbs P Waring P Sato N Torigoe T Itoh K Patel PS Shukla SN Palmqvist R Nagtegaal ID Wang Y DArrigo C Kopetz S Sinicrope FA Trinchieri G Gajewski TF Ascierto PA Fox BA 2012 Cancer classification using the Immunoscore a worldwide task force Journal of Translational Medicine 10 205 doi1011861479587610205 PMC 3554496 PMID 23034130Ku CS Cooper DN Wu M Roukos DH Pawitan Y Soong R Iacopetta B August 2012 Gene discovery in familial cancer syndromes by exome sequencing prospects for the elucidation of familial colorectal cancer type X Modern Pathology an Official Journal of the United States and Canadian Academy of Pathology Inc 25 8 105568 doi101038modpathol201262 PMID 22522846Koshiol J Lin SW July 2012 Can tissuebased immune markers be used for studying the natural history of cancer Annals of Epidemiology 22 7 52030 doi101016jannepidem201203001 PMC 3596808 PMID 22481034Fini L Grizzi F Laghi L 2012 Ettarh R ed Adaptive and Innate Immunity Non Clonal Players in Colorectal Cancer Progression InTech pp 32340 ISBN 9789535100621Dogan S Shen R Ang DC Johnson ML DAngelo SP Paik PK Brzostowski EB Riely GJ Kris MG Zakowski MF Ladanyi M November 2012 Molecular epidemiology of EGFR and KRAS mutations in 3026 lung adenocarcinomas higher susceptibility of women to smokingrelated KRASmutant cancers Clinical Cancer Research 18 22 616977 doi10115810780432CCR113265 PMC 3500422 PMID 23014527Spitz MR Caporaso NE Sellers TA December 2012 Integrative cancer epidemiologythe next generation Cancer Discovery 2 12 108790 doi10115821598290CD120424 PMC 3531829 PMID 23230187Shanmuganathan R Basheer NB Amirthalingam L Muthukumar H Kaliaperumal R Shanmugam K January 2013 Conventional and nanotechniques for DNA methylation profiling The Journal of Molecular Diagnostics JMD 15 1 1726 doi101016jjmoldx201206007 PMID 23127612Hughes LA Melotte V de Schrijver J de Maat M Smit VT Bovée JV French PJ van den Brandt PA Schouten LJ de Meyer T van Criekinge W Ahuja N Herman JG Weijenberg MP van Engeland M October 2013 The CpG island methylator phenotype whats in a name Cancer Research 73 19 585868 doi10115800085472CAN124306 PMID 23801749Hagland HR Søreide K March 2014 Cellular metabolism in colorectal carcinogenesis Influence of lifestyle gut microbiome and metabolic pathways Cancer Letters doi101016jcanlet201402026 PMID 24614287Bishehsari F Mahdavinia M Vacca M Malekzadeh R MarianiCostantini R May 2014 Epidemiological transition of colorectal cancer in developing countries environmental factors molecular pathways and opportunities for prevention World Journal of Gastroenterology WJG 20 20 605572 doi103748wjgv20i206055 PMC 4033445 PMID 24876728 ，並且成為美國癌症研究協會（AACR）Ogino S Molecular pathological epidemiology MPE Overview of its paradigm and wide applicability even without tumor tissue In Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research 2013 Oct 2730 National Harbor MD Cancer Prev Res Phila 20136 11 supplCN061 ，流行病學研究協會（SER）Kuller LH Bracken MB Ogino S Prentice RL Tracy RP The role of epidemiology in the era of molecular epidemiology and genomics Summary of the 2013 AJEsponsored Society of Epidemiologic Research Symposium Am J Epidemiol 2013178 913504 和美國預防腫瘤學會（ASPO）Epplein M Bostick RM Mu L Ogino S Braithwaite D Kanetsky PA Challenges and Opportunities in International Molecular Cancer Prevention Research An ASPO Molecular Epidemiology and the Environment and International Cancer Prevention Interest Groups Report Cancer Epidemiol Biomarkers Prev 201423 1126137 doi 10115810559965EPI140848 Epub 2014 Oct 2 等國際會議的專題。MPE 是採用分子病理學流行病學的方法從分子、個體和群體的水平進行病因學的研究。透過對現有的流行病學研究中組織樣本和資料的研究分析，荻野發表了大量的文章論述危險因素（如環境、飲食、生活方式和遺傳因素等）的暴露和疾病的分子病理學特徵之間的相互關係（例如，攜帶 PIK3CA 突變基因的結直腸癌），其中很多發現 Chan AT Ogino S Fuchs CS Aspirin use and risk of colorectal cancer according to cyclooxygenase2 expression N Engl J Med 2007356213142Chan AT Ogino S Fuchs CS Aspirin use and survival after diagnosis of colorectal cancer JAMA 2009302649658Morikawa T Kuchiba A Yamauchi M Meyerhardt JA Shima K Nosho K Chan AT Giovannucci E Fuchs CS Ogino S Association of CTNNB1 βcatenin alterations body mass index and physical activity with survival in patients with colorectal cancer JAMA 201130516851694 PMCIDPMC3087286109Straussman R Morikawa T Shee K BarzilyRokni M Qian ZR Du J Davis A Mongare MM Gould J Frederick DT Cooper ZA Chapman PB Solit DB Ribas A Lo RS Flaherty KT Ogino S Wargo JA Golub TR Tumor microenvironment contributes to innate RAFinhibitor resistance through HGF secretion Nature 2012487500504 PMCIDPMC3711467Nishihara R Lochhead P Kuchiba A Jung S Yamauchi M Liao X Imamura Y Qian ZR Morikawa T Wang M Spiegelman D Cho E Giovannucci E Fuchs CS Chan AT Ogino S Aspirin use and colorectal cancer incidence risk according to BRAF mutation status JAMA 201330925632571Ogino S Liao X Imamura Y Yamauchi M McCleary NJ Ng K Niedzwiecki D Saltz LB Mayer RJ Whittom R Hantel A Benson III AB Mowat RB Spiegelman D Goldberg RM Bertagnolli MM Meyerhardt JA Fuchs CS for the Alliance for Clinical Trials in Oncology Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial J Natl Cancer Inst 201310517891798Barry ER Morikawa T Butler BL Shrestha K de la Rosa R Yan KS Fuchs CS Magness ST Smits R Ogino S Kuo CJ Camargo FD Restriction of intestinal stem cell expansion and the regenerative response by YAP Nature 2013493106110 PMCIDPMC3536889Fink SP Yamauchi M Nishihara R Jung S Kuchiba A Wu K Cho E Giovannucci E Fuchs CS Ogino S Markowitz SD Chan AT Aspirin and the risk of colorectal cancer in relation to the expression of 15hydroxyprostaglandin dehydrogenase HPGD Sci Transl Med 20146233re2 以及闡述 MPE 的概念 Ogino S Galon J Fuchs CS Dranoff G Cancer immunology integrated analysis of host and tumor factors for personalized medicine Nat Rev Clin Oncol 20118711719Ogino S King EE Beck AH Sherman ME Milner DA Giovannucci E Interdisciplinary education to integrate pathology and epidemiology Towards molecular and populationlevel health science Am J Epidemiol 2012176659667Ogino S Giovannucci E Lifestyle factors and colorectal cancer microsatellite instability Molecular pathological epidemiology science based on unique tumour principle Int J Epidemiol 20124110721074Ogino S Fuchs CS Giovannucci E How many molecular subtypes Implications of the unique tumor principle in personalized medicine Expert Rev Mol Diagn 201212621628Ogino S Lochhead P Chan AT Nishihara R Cho E Wolpin BM Meyerhardt JA Meissner A Schernhammer ES Fuchs CS Giovannucci E April 2013 Molecular pathological epidemiology of epigenetics emerging integrative science to analyze environment host and disease Modern Pathology 26 4 46584Field AE Camargo Jr CA Ogino S The merits of subtyping obesity one size does not fit all JAMA 201331021472148Ogino S Lochhead P Giovannucci E Meyerhardt JA Fuchs CS Chan AT Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker power and promise of molecular pathological epidemiology Oncogene 20143329492955Lochhead P Chan AT Giovannucci E Fuchs CS Wu K Nishihara R OBrien M Ogino S Progress and opportunities in molecular pathological epidemiology of colorectal premalignant lesions Am J Gastroenterol 2014109 812051214 的文章都發表在該領域具有影響力的雜誌上。透過 MPE 的研究方法荻野發現了阿司匹林可以增加攜帶 PIK3CA 基因突變的結直腸癌患者的生存期 Liao X Lochhead P Nishihara R Morikawa T Kuchiba A Yamauchi M Imamura Y Qian ZR Baba Y Shima K Sun R Nosho K Meyerhardt JA Giovannucci E Fuchs CS Chan AT Ogino S Aspirin use tumor PIK3CA mutation and colorectalcancer survival N Engl J Med 201236715961606 ，內鏡篩查有助於降低結腸癌的發病率和死亡率，以及結腸鏡檢 5 年內發生的大腸癌與其 CIMP（CpG 島甲基化表型）和 MSI （微衛星不穩定性）有關 Nishihara R Wu K Lochhead P Morikawa T Liao X Qian ZR Inamura K Kim SA Kuchiba A Yamauchi M Imamura Y Willett WC Rosner BA Fuchs CS Giovannucci E Ogino S Chan AT Longterm colorectalcancer incidence and mortality after lower endoscopy N Engl J Med 201336910951105。Ogino 於 2013 年舉辦首屆分子病理流行病學（MPE）會議，並於 2014 年 12 月 45 號在波士頓召開第二次會議 The Ogino MPE lab httpoginompelabdanafarberorg Ogino S Campbell PT Nishihara R Phipps AI Beck AH Sherman ME Chan AT Troester MA Bass AJ Fitzgerald KC Irizarry RA Kelsey KT Nan H Peters U Poole EM Qian ZR Tamimi RM Tchetgen Tchetgen EJ Tworoger SS Zhang X Giovannucci EL van den Brandt PA Rosner BA Wang M Chatterjee N Begg CB， 。 荻野採用 MPE 的研究方法提出在大腸癌研究模型從兩段式結腸模型（近段和遠段結腸）Iacopetta B Are there two sides to colorectal cancer Int J Cancer 20021014038 Gervaz P Bucher P Morel P Two colonstwo cancers paradigm shift and clinical implications J Surg Oncol 2004882616 Carethers JM One colon lumen but two organs Gastroenterology 20111414112 Albuquerque C Bakker ER van Veelen W et al Colorectal cancers choosing sides Biochim Biophys Acta 2011181621931 到大腸連續模型 Yamauchi M Lochhead P Morikawa T Huttenhower C Chan AT Giovannucci E Fuchs C Ogino S Colorectal cancer a tale of two sides or a continuum Gut 2012 Jun61 67947 的轉變。該假設是透過對 1400 多例大腸癌病例分析，得出不同部位的結腸癌與其微衛星不穩定（MSI），CpG 島甲基化表型（CIMP）和 BRAF 突變頻率呈線性關係 Yamauchi M Morikawa T Kuchiba A Imamura Y Qian ZR Nishihara R Liao X Waldron L Hoshida Y Huttenhower C Chan AT Giovannucci E Fuchs CS Ogino S Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum Gut 201261847854 PMCIDPMC3345105 ，這一大腸連續模型已得到支援 Jess P Hansen IO Gamborg M Jess T Danish Colorectal Cancer Group A nationwide Danish cohort study challenging the categorisation into rightsided and leftsided colon cancer BMJ Open 2013 May 283 5Papagiorgis P Colorectal cancer dichotomous or continuum model Perhaps a combination of both Gut 2013 Oct62 10151920。 此外，荻野還提出了一些新的研究模式，包括 GWASMPE Ogino S Chan AT Fuchs CS Giovannucci E Gut 2011 Mar60 3397411 doi 101136gut2010217182 Epub 2010 Oct 29 Review PMID 21036793 Molecular pathological epidemiology of colorectal neoplasia an emerging transdisciplinary and interdisciplinary field ，獨特腫瘤原則 Ogino S Fuchs CS Giovannucci E Expert Rev Mol Diagn 2012 Jul12 66218 doi 101586erm1246 Review PMID 22845482 How many molecular subtypes Implications of the unique tumor principle in personalized medicine ，獨特疾病原則 Ogino S Lochhead P Chan AT Nishihara R Cho E Wolpin BM Meyerhardt JA Meissner A Schernhammer ES Fuchs CS Giovannucci E Mod Pathol 2013 Apr26 446584 doi 101038modpathol2012214 Epub 2013 Jan 11 Review PMID 23307060 Molecular pathological epidemiology of epigenetics emerging integrative science to analyze environment host and disease ，病因場效應模型 Lochhead P Chan AT Nishihara R Fuchs CS Beck AH Giovannucci E Ogino S Etiologic field effect reappraisal of the field effect concept in cancer predisposition and progression Mod Pathol 201528 11429 doi 101038modpathol201481 Epub 2014 Jun 13 PMID 24925058 （即多種治病因素包括飲食、生活方式、環境、微生物、激素和基因等及其相互作用下的形成腫瘤易感組織微環境，致使腫瘤形成、演化和進展）以及 生命歷程流行病學 MPE 模型 Nishi A Kawachi I Koenen KC Wu K Nishihara R Ogino S Lifecourse epidemiology and molecular pathological epidemiology Am J Prev Med 201548116119 ，所有這些模型都與 MPE 領域相關。 榮譽 2004 年，分子病理學協會（AMP），總裁獎 2011 年，美國加拿大病理學協會，拉姆茲科特蘭青年研究獎 2012 年，分子病理學協會（AMP），功勳獎 2014 年，湯森路透 The worlds Most Influential Minds2014 Thomson Reuter Retrieved September 5 2014， 最具影響力的科學家 2014 年，美國臨床調查協會（ASCI），委員 2014 年，美國實驗生物學會聯合會傑出科學獎委員會 httpwwwfaseborgAboutFASEBWhoWeAreGovernanceBoardOrdinaryCommitteesaspx Retrieved September 15 2014，委員 外部連結 Harvard TH Chan School of Public Health faculty profile httpwwwhsphharvardedushujiogino The Ogino MPE lab httpswebarchiveorgweb20190515032651httpoginompelabdanafarberorg DanaFarber Harvard Cancer Center faculty profile httpwwwdfhccharvardedumembershipprofilemember10990 Brigham Womens Hospital faculty profile httpresearchfacultybrighamandwomensorgBRIProfileaspxid5797 Harvard University faculty directory httpwwwharvardedufaculty） 參考文獻 Category 日本病理學家 Category 東京大學校友 Category 哈佛大學教授 Category 哈佛醫學院教師 Category 日本醫學家 Category 在美國的日本學者