ymoslem/acl-abstracts huggingface dataset:
Gaussian Distributed Prototypical Network for Few-shot Genomic Variant Detection (2023)

Automatically identifying genetic mutations in the cancer literature using text mining technology has been an important way to study the vast amount of cancer medical literature. However, novel knowledge regarding the genetic variants proliferates rapidly, though current supervised learning models struggle with discovering these unknown entity types. Few-shot learning allows a model to perform effectively with great generalization on new entity types, which has not been explored in recognizing cancer mutation detection. This paper addresses cancer mutation detection tasks with few-shot learning paradigms. We propose GDPN framework, which models the label dependency from the training examples in the support set and approximates the transition scores via Gaussian distribution. The experiments on three benchmark cancer mutation datasets show the effectiveness of our proposed model.
Exploring Partial Knowledge Base Inference in Biomedical Entity Linking (2023)

Biomedical entity linking (EL) consists of named entity recognition (NER) and named entity disambiguation (NED). EL models are trained on corpora labeled by a predefined KB. However, it is a common scenario that only entities within a subset of the KB are precious to stakeholders. We name this scenario partial knowledge base inference; training an EL model with one KB and inferring on the part of it without further training. In this work, we give a detailed definition and evaluation procedures for this practically valuable but significantly understudied scenario and evaluate methods from three representative EL paradigms. We construct partial KB inference benchmarks and witness a catastrophic degradation in EL performance due to dramatically precision drop. Our findings reveal these EL paradigms can not correctly handle unlinkable mentions (NIL), so they are not robust to partial KB inference. We also propose two simple-and-effective redemption methods to combat the NIL issue with little computational overhead.
Boosting Radiology Report Generation by Infusing Comparison Prior (2023)

Recent transformer-based models have made significant strides in generating radiology reports from chest X-ray images. However, a prominent challenge remains; these models often lack prior knowledge, resulting in the generation of synthetic reports that mistakenly reference non-existent prior exams. This discrepancy can be attributed to a knowledge gap between radiologists and the generation models. While radiologists possess patient-specific prior information, the models solely receive X-ray images at a specific time point. To tackle this issue, we propose a novel approach that leverages a rule-based labeler to extract comparison prior information from radiology reports. This extracted comparison prior is then seamlessly integrated into state-of-the-art transformer-based models, enabling them to produce more realistic and comprehensive reports. Our method is evaluated on English report datasets, such as IU X-ray and MIMIC-CXR. The results demonstrate that our approach surpasses baseline models in terms of natural language generation metrics. Notably, our model generates reports that are free from false references to non-existent prior exams, setting it apart from previous models. By addressing this limitation, our approach represents a significant step towards bridging the gap between radiologists and generation models in the domain of medical report generation.
Using Bottleneck Adapters to Identify Cancer in Clinical Notes under Low-Resource Constraints (2023)

Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to specialised transformers such as BioBERT on a dataset containing clinical notes along with a set of annotations indicating whether a sample is cancer-related or not. Furthermore, we specifically employ efficient fine-tuning methods from NLP, namely, bottleneck adapters and prompt tuning, to adapt the models to our specialised task. Our evaluations suggest that fine-tuning a frozen BERT model pre-trained on natural language and with bottleneck adapters outperforms all other strategies, including full fine-tuning of the specialised BioBERT model. Based on our findings, we suggest that using bottleneck adapters in low-resource situations with limited access to labelled data or processing capacity could be a viable strategy in biomedical text mining.
Evaluating and Improving Automatic Speech Recognition using Severity (2023)

A common metric for evaluating Automatic Speech Recognition (ASR) is Word Error Rate (WER) which solely takes into account discrepancies at the word-level. Although useful, WER is not guaranteed to correlate well with human judgment or performance on downstream tasks that use ASR. Meaningful assessment of ASR mistakes becomes even more important in high-stake scenarios such as health-care. We propose 2 general measures to evaluate the severity of mistakes made by ASR systems, one based on sentiment analysis and another based on text embeddings. We evaluate these measures on simulated patient-doctor conversations using 5 ASR systems. Results show that these measures capture characteristics of ASR errors that WER does not. Furthermore, we train an ASR system incorporating severity and demonstrate the potential for using severity not only in the evaluation, but in the development of ASR. Advantages and limitations of this methodology are analyzed and discussed.
Zero-shot Temporal Relation Extraction with ChatGPT (2023)

The goal of temporal relation extraction is to infer the temporal relation between two events in the document. Supervised models are dominant in this task. In this work, we investigate ChatGPT`s ability on zero-shot temporal relation extraction. We designed three different prompt techniques to break down the task and evaluate ChatGPT. Our experiments show that ChatGPT`s performance has a large gap with that of supervised methods and can heavily rely on the design of prompts. We further demonstrate that ChatGPT can infer more small relation classes correctly than supervised methods. The current shortcomings of ChatGPT on temporal relation extraction are also discussed in this paper. We found that ChatGPT cannot keep consistency during temporal inference and it fails in actively long-dependency temporal inference.
Good Data, Large Data, or No Data? Comparing Three Approaches in Developing Research Aspect Classifiers for Biomedical Papers (2023)

The rapid growth of scientific publications, particularly during the COVID-19 pandemic, emphasizes the need for tools to help researchers efficiently comprehend the latest advancements. One essential part of understanding scientific literature is research aspect classification, which categorizes sentences in abstracts to Background, Purpose, Method, and Finding. In this study, we investigate the impact of different datasets on model performance for the crowd-annotated CODA-19 research aspect classification task. Specifically, we explore the potential benefits of using the large, automatically curated PubMed 200K RCT dataset and evaluate the effectiveness of large language models (LLMs), such as LLaMA, GPT-3, ChatGPT, and GPT-4. Our results indicate that using the PubMed 200K RCT dataset does not improve performance for the CODA-19 task. We also observe that while GPT-4 performs well, it does not outperform the SciBERT model fine-tuned on the CODA-19 dataset, emphasizing the importance of a dedicated and task-aligned datasets dataset for the target task.
Sentiment-guided Transformer with Severity-aware Contrastive Learning for Depression Detection on Social Media (2023)

Early identification of depression is beneficial to public health surveillance and disease treatment. There are many models that mainly treat the detection as a binary classification task, such as detecting whether a user is depressed. However, identifying users' depression severity levels from posts on social media is more clinically useful for future prevention and treatment. Existing severity detection methods mainly model the semantic information of posts while ignoring the relevant sentiment information, which can reflect the user`s state of mind and could be helpful for severity detection. In addition, they treat all severity levels equally, making the model difficult to distinguish between closely-labeled categories. We propose a sentiment-guided Transformer model, which efficiently fuses social media posts' semantic information with sentiment information. Furthermore, we also utilize a supervised severity-aware contrastive learning framework to enable the model to better distinguish between different severity levels. The experimental results show that our model achieves superior performance on two public datasets, while further analysis proves the effectiveness of all proposed modules.
Exploring Drug Switching in Patients: A Deep Learning-based Approach to Extract Drug Changes and Reasons from Social Media (2023)

Social media (SM) can provide valuable information about patients' experiences with multiple drugs during treatments. Although information extraction from SM has been well-studied, drug switches detection and reasons behind these switches from SM have not been studied yet. Therefore, in this paper, we present a new SM listening approach for analyzing online patient conversations that contain information about drug switching, drug effectiveness, side effects, and adverse drug reactions. We describe a deep learning-based approach for identifying instances of drug switching in SM posts, as well as a method for extracting the reasons behind these switches. To train and test our models, we used annotated SM data from internal dataset which is automatically created using a rule-based method. We evaluated our models using Text-to-Text Transfer Transformer (T5) and found that our SM listening approach can extract medication change information and reasons with high accuracy, achieving an F1-score of 98{\%} and a ROUGE-1 score of 93{\%}, respectively. Overall, our results suggest that our SM listening approach has the potential to provide valuable insights into patients' experiences with drug treatments, which can be used to improve patient outcomes and the effectiveness of drug treatments.
Is the ranking of PubMed similar articles good enough? An evaluation of text similarity methods for three datasets (2023)

The use of seed articles in information retrieval provides many advantages, such as a longercontext and more details about the topic being searched for. Given a seed article (i.e., a PMID), PubMed provides a pre-compiled list of similar articles to support the user in finding equivalent papers in the biomedical literature. We aimed at performing a quantitative evaluation of the PubMed Similar Articles based on three existing biomedical text similarity datasets, namely, RELISH, TREC-COVID, and SMAFIRA-c. Further, we carried out a survey and an evaluation of various text similarity methods on these three datasets. Our experiments considered the original title and abstract from PubMed as well as automatically detected sections and manually annotated relevant sentences. We provide an overview about which methods better performfor each dataset and compare them to the ranking in PubMed similar articles. While resultsvaried considerably among the datasets, we were able to obtain a better performance thanPubMed for all of them. Datasets and source codes are available at: \url{https://github.com/mariananeves/reranking}
How Much do Knowledge Graphs Impact Transformer Models for Extracting Biomedical Events? (2023)

Biomedical event extraction can be divided into three main subtasks; (1) biomedical event trigger detection, (2) biomedical argument identification and (3) event construction. This work focuses in the two first subtasks. For the first subtask we analyze a set of transformer language models that are commonly used in the biomedical domain to evaluate and compare their capacity for event trigger detection. We fine-tune the models using seven manually annotated corpora to assess their performance in different biomedical subdomains. SciBERT emerged as the highest performing model, presenting a slight improvement compared to baseline models. Then, for the second subtask we construct a knowledge graph (KG) from the biomedical corpora and integrate its KG embeddings to SciBERT to enrich its semantic information. We demonstrate that adding the KG embeddings to the model improves the argument identification performance by around 20 {\%}, and by around 15 {\%} compared to two baseline models. Our results suggest that fine-tuning a transformer model that is pretrained from scratch with biomedical and general data allows to detect event triggers and identify arguments covering different biomedical subdomains, and therefore improving its generalization. Furthermore, the integration of KG embeddings into the model can significantly improve the performance of biomedical event argument identification, outperforming the results of baseline models.
An end-to-end neural model based on cliques and scopes for frame extraction in long breast radiology reports (2023)

We consider the task of automatically extracting various overlapping frames, i.e, structured entities composed of multiple labels and mentions, from long clinical breast radiology documents. While many methods exist for related topics such as event extraction, slot filling, or discontinuous entity recognition, a challenge in our study resides in the fact that clinical reports typically contain overlapping frames that span multiple sentences or paragraphs. We propose a new method that addresses these difficulties and evaluate it on a new annotated corpus. Despite the small number of documents, we show that the hybridization between knowledge injection and a learning-based system allows us to quickly obtain proper results. We will also introduce the concept of scope relations and show that it both improves the performance of our system, and provides a visual explanation of the predictions.
DISTANT: Distantly Supervised Entity Span Detection and Classification (2023)

We propose a distantly supervised pipeline NER which executes entity span detection and entity classification in sequence named DISTANT (DIstantly Supervised enTity spAN deTection and classification).The former entity span detector extracts possible entity mention spans by the distant supervision. Then the later entity classifier assigns each entity span to one of the positive entity types or none by employing a positive and unlabeled (PU) learning framework. Two models were built based on the pre-trained SciBERT model and fine-tuned with the silver corpus generated by the distant supervision. Experimental results on BC5CDR and NCBI-Disease datasets show that our method outperforms the end-to-end NER baselines without PU learning by a large margin. In particular, it increases the recall score effectively.
Large Language Models as Instructors: A Study on Multilingual Clinical Entity Extraction (2023)

In clinical and other specialized domains, data are scarce due to their confidential nature. This lack of data is a major problem when fine-tuning language models. Nevertheless, very large language models (LLMs) are promising for the medical domain but cannot be used directly in healthcare facilities due to data confidentiality issues. We explore an approach of annotating training data with LLMs to train smaller models more adapted to our problem. We show that this method yields promising results for information extraction tasks.
Event-independent temporal positioning: application to French clinical text (2023)

Extracting temporal relations usually entails identifying and classifying the relation between two mentions. However, the definition of temporal mentions strongly depends on the text type and the application domain. Clinical text in particular is complex. It may describe events that occurred at different times, contain redundant information and a variety of domain-specific temporal expressions. In this paper, we propose a novel event-independent representation of temporal relations that is task-independent and, therefore, domain-independent. We are interested in identifying homogeneous text portions from a temporal standpoint and classifying the relation between each text portion and the document creation time. Temporal relation extraction is cast as a sequence labeling task and evaluated on oncology notes. We further evaluate our temporal representation by the temporal positioning of toxicity events of chemotherapy administrated to colon and lung cancer patients described in French clinical reports. An overall macro F-measure of 0.86 is obtained for temporal relation extraction by a neural token classification model trained on clinical texts written in French. Our results suggest that the toxicity event extraction task can be performed successfully by automatically identifying toxicity events and placing them within the patient timeline (F-measure .62). The proposed system has the potential to assist clinicians in the preparation of tumor board meetings.
ADEQA: A Question Answer based approach for joint ADE-Suspect Extraction using Sequence-To-Sequence Transformers (2023)

Early identification of Adverse Drug Events (ADE) is critical for taking prompt actions while introducing new drugs into the market. These ADEs information are available through various unstructured data sources like clinical study reports, patient health records, social media posts, etc. Extracting ADEs and the related suspect drugs using machine learning is a challenging task due to the complex linguistic relations between drug ADE pairs in textual data and unavailability of large corpus of labelled datasets. This paper introduces ADEQA, a question- answer(QA) based approach using quasi supervised labelled data and sequence-to-sequence transformers to extract ADEs, drug suspects and the relationships between them. Unlike traditional QA models, natural language generation (NLG) based models don`t require extensive token level labelling and thereby reduces the adoption barrier significantly. On a public ADE corpus, we were able to achieve state-of-the-art results with an F1 score of 94{\%} on establishing the relationships between ADEs and the respective suspects.
Privacy Aware Question-Answering System for Online Mental Health Risk Assessment (2023)

Social media platforms have enabled individuals suffering from mental illnesses to share their lived experiences and find the online support necessary to cope. However, many users fail to receive genuine clinical support, thus exacerbating their symptoms. Screening users based on what they post online can aid providers in administering targeted healthcare and minimize false positives. Pre-trained Language Models (LMs) can assess users' social media data and classify them in terms of their mental health risk. We propose a Question-Answering (QA) approach to assess mental health risk using the Unified-QA model on two large mental health datasets. To protect user data, we extend Unified-QA by anonymizing the model training process using differential privacy. Our results demonstrate the effectiveness of modeling risk assessment as a QA task, specifically for mental health use cases. Furthermore, the model`s performance decreases by less than 1{\%} with the inclusion of differential privacy. The proposed system`s performance is indicative of a promising research direction that will lead to the development of privacy-aware diagnostic systems.
AliBERT: A Pre-trained Language Model for French Biomedical Text (2023)

Over the past few years, domain specific pretrained language models have been investigated and have shown remarkable achievements in different downstream tasks, especially in biomedical domain. These achievements stem on the well known BERT architecture which uses an attention based self-supervision for context learning of textual documents. However, these domain specific biomedical pretrained language models mainly use English corpora. Therefore, non-English, domain-specific pretrained models remain quite rare, both of these requirements being hard to achieve. In this work, we proposed AliBERT, a biomedical pretrained language model for French and investigated different learning strategies. AliBERT is trained using regularized Unigram based tokenizer trained for this purpose. AliBERT has achieved state of the art F1 and accuracy scores in different down-stream biomedical tasks. Our pretrained model manages to outperform some French non domain-specific models such as CamemBERT and FlauBERT on diverse down-stream tasks, with less pretraining and training time and with much smaller corpora.
Multiple Evidence Combination for Fact-Checking of Health-Related Information (2023)

Fact-checking of health-related claims has become necessary in this digital age, where any information posted online is easily available to everyone. The most effective way to verify such claims is by using evidences obtained from reliable sources of medical knowledge, such as PubMed. Recent advances in the field of NLP have helped automate such fact-checking tasks. In this work, we propose a domain-specific BERT-based model using a transfer learning approach for the task of predicting the veracity of claim-evidence pairs for the verification of health-related facts. We also improvise on a method to combine multiple evidences retrieved for a single claim, taking into consideration conflicting evidences as well. We also show how our model can be exploited when labelled data is available and how back-translation can be used to augment data when there is data scarcity.
Building a Corpus for Biomedical Relation Extraction of Species Mentions (2023)

We present a manually annotated new corpus, Species-Species Interaction (SSI), for extracting meaningful binary relations between species, in biomedical texts, at sentence level, with a focus on the gut microbiota. The corpus leverages PubTator to annotate species in full-text articles after evaluating different NER species taggers. Our first results are promising for extracting relations between species using BERT and its biomedical variants.
Automated Extraction of Molecular Interactions and Pathway Knowledge using Large Language Model, Galactica: Opportunities and Challenges (2023)

Understanding protein interactions and pathway knowledge is essential for comprehending living systems and investigating the mechanisms underlying various biological functions and complex diseases. While numerous databases curate such biological data obtained from literature and other sources, they are not comprehensive and require considerable effort to maintain. One mitigation strategies can be utilizing large language models to automatically extract biological information and explore their potential in life science research. This study presents an initial investigation of the efficacy of utilizing a large language model, Galactica in life science research by assessing its performance on tasks involving protein interactions, pathways, and gene regulatory relation recognition. The paper details the results obtained from the model evaluation, highlights the findings, and discusses the opportunities and challenges.