[EVO Shift 4G Themes and Apps] riggsandroid:
This thread is meant to serve as a compilation from the community of what .apk files can be removed safely without causing issues on your phone.

Currently these apps have been removed by the recovery exploit in Titanium Backup or Frozen in Titanium Backup:

Since we have full root now, just remove using whatever method you'd like

SAFE TO REMOVE

Adobe Reader
Amazon Kindle
Amazon MP3
Calculator
Calculator Widget 3.00
Calendar Widget
Facebook
Footprints and Widget
FriendStream 1.0
FriendStream Widget 1.0
HTC Facebook
HTC Keyboard
HTCLockscreen.apk - Stock Lockscreen returns, must reboot after removing HTCLockscreen.apk
HTC Mobile Guide
HTC Sense
HtcSyncwidget.apk
HtcSyncwidget.odex
News1.0
News Widget 1.00
Peep
Sprint Hotspot 1.00
Sprint NFL and Widget
Sprint Nascar and Widget
Sprint Voicemail
Sprint Zone SZ_2.1.12
Stockes Widget 1.00
Teeter

APPS removed by bcnice20's script
rm -R /system/app/nascar09-prod-release.apk
rm -R /system/app/Sprint_Navigator.apk
rm -R /system/app/sfl-prod-release.apk
rm -R /system/app/HTCMobileGuide_Speedy.apk
rm -R /system/app/amazonmp3.apk
rm -R /system/app/AppSharing.apk
rm -R /system/app/AppSharing.odex
rm -R /system/app/com.htc.FMRadioWidget.apk
rm -R /system/app/com.htc.FMRadioWidget.odex
rm -R /system/app/com.htc.FriendStreamWidget.apk
rm -R /system/app/com.htc.FriendStreamWidget.odex
rm -R /system/app/com.htc.MusicWidget.apk
rm -R /system/app/com.htc.MusicWidget.odex
rm -R /system/app/com.htc.NewsReaderWidget.apk
rm -R /system/app/com.htc.NewsReaderWidget.odex
rm -R /system/app/com.htc.StockWidget.apk
rm -R /system/app/com.htc.StockWidget.odex
rm -R /system/app/com.htc.TwitterWidget.apk
rm -R /system/app/com.htc.TwitterWidget.odex
rm -R /system/app/com.htc.WeatherWidget.apk
rm -R /system/app/com.htc.WeatherWidget.odex
rm -R /system/app/DCSStock.apk
rm -R /system/app/DCSStock.odex
rm -R /system/app/FriendStream.apk
rm -R /system/app/FriendStream.odex
rm -R /system/app/htcbookmarkwidget.apk
rm -R /system/app/htcbookmarkwidget.odex
rm -R /system/app/HtcCalculatorWidget.apk
rm -R /system/app/HtcCalculatorWidget.odex
rm -R /system/app/htccalendarwidgets.apk
rm -R /system/app/htccalendarwidgets.odex
rm -R /system/app/HtcClockWidget.apk
rm -R /system/app/HtcClockWidget.odex
rm -R /system/app/htccontactwidgets.apk
rm -R /system/app/htccontactwidgets.odex
rm -R /system/app/HtcFootprints.apk
rm -R /system/app/HtcFootprints.odex
rm -R /system/app/HtcFootprintsWidget.apk
rm -R /system/app/HtcFootprintsWidget.odex
rm -R /system/app/htcmailwidgets.apk
rm -R /system/app/htcmailwidgets.odex
rm -R /system/app/htcmsgwidgets.apk
rm -R /system/app/htcmsgwidgets.odex
rm -R /system/app/HtcPhotoWidget.apk
rm -R /system/app/HtcPhotoWidget.odex
rm -R /system/app/HtcProfileWidget.apk
rm -R /system/app/HtcProfileWidget.odex
rm -R /system/app/HtcRingtoneWidget.apk
rm -R /system/app/HtcRingtoneWidget.odex
rm -R /system/app/htcsettingwidgets.apk
rm -R /system/app/htcsettingwidgets.odex
rm -R /system/app/HtcSyncwidget.apk
rm -R /system/app/HtcSyncwidget.odex
rm -R /system/app/HtcTwitter.apk
rm -R /system/app/HtcTwitter.odex
rm -R /system/app/Rosie.apk
rm -R /system/app/Rosie.odex
rm -R /system/app/Stock.apk
rm -R /system/app/Stock.odex
rm -R /system/app/teeter.apk
rm -R /system/app/teeter.odex

NOT SAFE TO REMOVE

com.htc.socialnetwork

Script to remove files - MUST BE RUN EACH REBOOT DUE TO TEMP ROOT - Provided by bcnice20.

To remove via recovery exploit use the following steps. (PLEASE NOTE THIS REMOVES THE FILE COMPLETELY FROM YOUR SYSTEM)

1. Open Titanium backup (if you don't have it download it here and PRO key here)

2. Click Backup/Restore and a full list of installed apps should show up (if not, post for some help)

3. Long press on whatever app you are looking to remove and scroll to the bottom of the new pop up.

4. Click Force remove app (by recovery exploit) and receive a prompt with a warning and thanks to Paul O'Brien for discovering the exploit.

5. Click Yes

6. Phone will reboot and flash a black screen with a red question mark for a short time, then reboot again.

7. After fully rebooted, you will find your app gone. METHOD NOT VALID ANYMORE DUE TO ROOT METHODS

Suggestion from cloverdave:

DISCLAIMER: I, nor anyone here, is responsible for damage done to your device in this process. All information here is assembled based on input from all users of this thread/forum.