[Moto G4 Plus Guides, News, & Discussion] echo92:
Unlikely - the OTA would possibly fail and also leave you in a TWRP soft bootloop unless you booted to bootloader and then selected 'Start' to boot to system.

As this OTA will only flash on NPJS25.93-14-8 systems (looking at the updater script), the easiest way would be to use the NPJS25.93-14-8 stock ROM to revert to a fully stock device. Of course, this will remove root and TWRP on your device, but OTAs require a clean, unmodified device to work from.

Assuming you are currently on NPJS25.93-14-8 and were fully updated before flashing TWRP and rooting, you may be able to use the following flashing commands with the fastboot stock ROM to revert to stock without affecting your data. These commands are edited assuming your GPT and bootloader are the same patch level as NPJS25.93-14-8. As always, back up your data in case you need to factory reset, and also this depends on your device being formally and fully updated to NPJS25.93-14-8 previously, if not formally updated (including bootloader to B1:06), you may run into issues including a hard brick. If you are not sure, ignore the following flashing commands and fully flash the NPJS25.93-14-8 stock ROM as per in the linked post. Or wait for the TWRP flashable of the NPJS25.93-14-10 system ROM (which only flashes the system side of the build).

fastboot flash logo logo.bin
fastboot flash boot boot.img
fastboot flash recovery recovery.img
fastboot flash dsp adspso.bin
fastboot flash oem oem.img
fastboot flash system system.img_sparsechunk.0
fastboot flash system system.img_sparsechunk.1
fastboot flash system system.img_sparsechunk.2
fastboot flash system system.img_sparsechunk.3
fastboot flash system system.img_sparsechunk.4
fastboot flash system system.img_sparsechunk.5
fastboot flash system system.img_sparsechunk.6
fastboot flash system system.img_sparsechunk.7
fastboot erase cache
fastboot reboot

The stock ROM for the NPJS25.93-14-8 build is here: https://xdaforums.com/moto-g4-plus/how-to/stock-rom-npjs25-93-14-4-march-1-t3608138

A formally updated system to NPJS25.93-14-8 should include:

Bootloader version at B1:06.

Modem version ending in 62.01R.

Security patch at 1 June 2017.

After this, you should be able to update to NPJS25.93-14-10 via OTA. Needless to say, after you update via OTA, it therefore becomes risky to flash the June 2017 stock ROM or any older ROMs. As we've seen previously, downgrading and then attempting to update via OTA runs a high risk of hard bricking, and it may be the case that the June 2017 blankflash we have no longer works once updated to September 2017. Be careful. If you need to revert back to stock after flashing the September 2017 OTA, wait for the NPJS25.93-14-10 stock ROM.

EDIT - I saw from your previous posts asking about the NPJ25.93-14-8.1 update. If you've updated from NPJ25.93-14 to NPJS25.93-14-8.1, you likely won't be able to flash this update anyway as the expected build is different to what the NPJS25.93-14-10 update is expecting.

For NPJ25.93-14-8.1:

Package expects build thumbprint of 7.0/NPJ25.93-14-8.1/2:user/release-keys or 7.0/NPJ25.93-14/16:user/release-keys

For NPJS25.93-14-10:

Package expects build thumbprint of 7.0/NPJS25.93-14-10/10:user/release-keys or 7.0/NPJS25.93-14-8/8:user/release-keys