[Google Pixel Questions & Answers] roirraW "edor" ehT:
For what it's worth, I have both phones.

TL;DR:

I bought my wife and I the unlocked HTC 10 at the $500 price to use on Verizon. The next day I became aware of Best Buy's Pixel 32 GB deal for straight $9.99 a month (or $240 buyout like I and others did), and I ordered two. My main reason was because I was coming from a VS985 LG G3 with a Micro SIM and I didn't want to step into a Verizon store to talk them into giving me Nano SIMs to use with my unofficial configuration of using an unlocked HTC 10 on Verizon's network, plus to have to have said Nano SIMs activated via phone since in that case I wouldn't have had an actual Verizon device that was capable of activating the SIMs.

I activated the SIMs in the Pixels and then put them in the HTC 10 and purchased the SunShine license for both phones and jumped through the firmware/ROM hoops I need to in order to have it work right.

First, I'm not on an unlimited data account so to me, using the Pixel with only 32 GB is relatively unrealistic to me. In it's favor, Google Photos only on the Pixel provides free unlimited full resolution not-further-compressed picture and video backups, and also has the feature to automatically clear space on the storage when it's needed by removing backed up photos. This is an amazing feature and would use it even if I had a 128 GB Pixel.

Second, my wife just went without a working smartphone for more than a month, so I sold one of the Pixels and kept the other to play with and to keep as a backup in case one of our HTCs has an unexpected problem anytime over the next couple of years. So far I have only a) unlocked the bootloader with Depixel8 (which might not work now if a Pixel has received the December update before using it) and b) I put the complete 7.1.1 stock ROM image on there.

I likely will not root the phone so that I can take OTAs painlessly. If I were using the Pixel as my daily phone I wouldn't be able to stand it without root and modifications. I'm assuming that most modifications I would want don't even exist yet, and I know that others I currently use don't exist for Nougat yet, like Xposed.

Although I prefer not to have to jump through ANY hoops to use the 10 on Verizon, the fact that there are still little nit-picky preference things that cause me to want to use a stock-based custom ROM over completely stock makes the point moot since I still won't receive OTAs except as provided by the particular ROM(s) I use.

The phone is still a lot easier to deal with than the LG G3 regarding hoops needing to jump through when new OTAs come out, and mix/match firmware caveats/bricks/etc. I could handle the Pixel's 5" screen if I was using it daily but I prefer larger. I really wouldn't want to go smaller than the 10's 5.2" screen.

Both phones feel very well built, the 10 even more so than the Pixel. The Pixel is very...compact. I mean, it's heavy for it's size, but not overly so, and it is solid.

I don't think you'll go wrong overall with either, depending on what your usage will be, what your Verizon plan is like and what your expectations are. I have pretty high requirements as far as convenience so that puts the Pixel out in several ways, but it'll make a great backup phone for my wife and I.