[Sprint HTC EVO 4G LTE] closeone:
Hello theothermillion. Thanks. Sorry for the late response. I think you'll find this one worth it though.

These apps should be safe to disable. I compiled this list myself. It may have some errors.

I can make a file that will remove this stuff from recovery. Just let me know what you don't want removed, and I'll see what I can do for you. Some of this will already be removed with a custom ROM. As aic223 suggested, a backup should be made before messing with "core" files. If you disable Rosie, make sure you have a custom launcher installed.

==<More HTC Specific (Keep Swype.apk if you want the Swype Keyboard)>==

4578_SPC_HTC_Mobile_Guide_Jewel.apk
FriendStream.apk
HTC_HTC_Jet-SmartDeviceManager_3_1_2D2012_02_26t18_03-Final.apk
HtcSkydriveGLRPlugin.apk
JETCET_PRINT_Resources.apk
JETCET_PRINT_S40.apk
Swype.apk

==<Removable Third Party Apps/Plugins>==

Dropbox.apk
Facebook.apk
Facebook_Client.apk
FacebookEngine.apk
Flickr.apk
FlickrEngine.apk
HtcDropboxGLRPlugin.apk
install_flash_player.apk
MyDropbox.apk
PDF_Viewer_F_A.apk
PolarisOffice.apk
SoundHound_Freemium.apk
TuneIn.apk
Twitter.apk
TwitterEngine.apk

==<The Sense Launcher>==

Rosie.apk

==<Extra Keyboard Languages>==

IMEXT9Bulgaria.apk
IMEXT9Croatian.apk
IMEXT9Czech.apk
IMEXT9Danish.apk
IMEXT9Dutch.apk
IMEXT9Estonian.apk
IMEXT9Finnish.apk
IMEXT9French.apk
IMEXT9German.apk
IMEXT9Greek.apk
IMEXT9Hungarian.apk
IMEXT9Italian.apk
IMEXT9Latvian.apk
IMEXT9Lithuanian.apk
IMEXT9Norwegian.apk
IMEXT9Polish.apk
IMEXT9Portuguese.apk
IMEXT9Romanian.apk
IMEXT9Russian.apk
IMEXT9Serbian.apk
IMEXT9Slovak.apk
IMEXT9Slovanian.apk
IMEXT9Spanish.apk
IMEXT9Swedish.apk
IMEXT9Turkish.apk

==<Live Wallpapers (Android Base and HTC Live)>==

Basic.apk
HoloSpiral.apk
HtcImageWallpaper.apk
HtcLavaLiveWallpaper.apk
HtcWeatherLiveWallpaper.apk
MagicSmoke.apk
MusicVisualization.apk
NoiseField.apk
PhaseBeam.apk
StreakLiveWallpaper.apk

==<HTC Lock Screen and all Extra Extensions>==

HtcLockScreen.apk
Idlescreen_Base.apk
IdleScreen_People.apk
IdleScreen_Photo.apk
Idlescreen_productivity.apk
idlescreen_shortcut.apk
idlescreen_social.apk
IdleScreen_Stock_Yahoo.apk
IdleScreen_Weather.apk

==<HTC Widgets (Useless if Rosie is removed) - One or two Base Android ones might have been thrown in there>==
CalculatorWidget.apk
HTC_Widget_Watch_3D.apk
HtcAutoRotateWidget.apk
HtcBackgroundDataWidget.apk
HtcBookmarkWidget.apk
htccalendarwidgets3d.apk
HtcClockWidget.apk
HtcContactWidgets.apk
HtcDataRoamingWidget.apk
HtcDataStripWidget.apk
HtcFMRadioWidget.apk
HtcFriendStreamWidget_3D.apk
HtcMailWidgets.apk
HtcMsgWidgets.apk
HtcMusicWidget.apk
HtcPhotoWidget.apk
HtcPowerStripWidget.apk
HtcProfilesWidget.apk
HtcRingtoneWidget.apk
HtcScreenBrightnessWidget.apk
HtcScreenTimeoutWidget.apk
HtcSettingWidgets.apk
HtcStoreWidget.apk
HtcSyncWidget.apk
MyTaskWidget.apk
StockWidget.apk
WeatherWidget.apk

==<Extra HTC Skins>==

Aluminum.apk
Fracture.apk
Infinite.apk
Matte.apk
Serene.apk

==<Spy(esque) APKs>==

CheckinProvider.apk
HtcCOTAClient.apk
HtcFeedback.apk
MyReportAgent.apk
Smith.apk

~co~

(Safe to disable Sense Apps HTC EVO 4G LTE) <- Should help this post to show up in the search results if anyone is looking for it.