[Droid Incredible Android Development] JWhetstone02:
I remove a lot of files every time I flash a nightly. If I'm not going to use it, I'm not going to want it on my phone :p

You could use ADB through the command prompt and do it one by one...but a script is much much easier :)

So if you are familiar with the app GScript and linux bash commands, then you could remove em too :)

I have removed all this and have not one problem at all...

(I organized it up a little so you can see what was taken out)

#!/system/bin/sh

echo "Setting /system to read/write"

mount -o rw,remount -t yaffs2 /dev/block/mtdblock3 /system

echo "Removing unwanted Apps."

#Removes HTC Car Panel
echo "--Removing HTC Car Panel"
rm /system/app/HtcCarPanel.apk
rm /data/dalvik-cache/system@app@HtcCarPanel.apk@classes.dex

#Removes HTC Stocks
echo "--Removing HTC Stocks"
rm /system/app/DCSImpl.apk
rm /system/app/DCSStock.apk
rm /system/app/DCSUtility.apk
rm /data/dalvik-cache/system@app@DCSImpl.apk@classes.dex
rm /data/dalvik-cache/system@app@DCSStock.apk@classes.dex
rm /data/dalvik-cache/system@app@DCSUtility.apk@classes.dex

#Removes HTC Facebook for Sense
echo "--Removing HTC Facebook"
rm /system/app/HtcFacebook.apk
rm /data/dalvik-cache/system@app@HtcFacebook.apk@classes.dex

#Removes Flickr
echo "--Removing Flickr"
rm /system/app/Flickr.apk
rm /data/dalvik-cache/system@app@Flickr.apk@classes.dex

#Removes HTC FM Radio
echo "--Removing HTC FM Radio"
rm /system/app/HtcFMRadio.apk
rm /system/app/com.htc.FMRadioWidget.apk
rm /data/dalvik-cache/system@app@HtcFMRadio.apk@classes.dex
rm /data/dalvik-cache/system@app@com.htc.FMRadioWidget.apk@classes.dex

#Removes Friend Stream
echo "--Removing FriendStream"
rm /system/app/FriendStream.apk
rm /system/app/com.htc.FriendStreamWidget.apk
rm /data/dalvik-cache/system@app@FriendStream.apk@classes.dex
rm /data/dalvik-cache/system@app@com.htc.FriendStreamWidget.apk@classes.dex

#Removes Twitter
echo "--Removing Twitter"
rm /system/app/HtcTwitter.apk
rm /system/app/com.htc.TrendsWidget.apk
rm /system/app/com.htc.TwitterWidget.apk
rm /data/dalvik-cache/system@app@HtcTwitter.apk@classes.dex
rm /data/dalvik-cache/system@app@com.htc.TrendsWidget.apk@classes.dex
rm /data/dalvik-cache/system@app@com.htc.TwitterWidget.apk@classes.dex

#Removes HTC Mail Application
echo "--Removing HTC Mail"
rm /system/app/Mail.apk
rm /system/app/htcmailwidgets.apk
rm /data/dalvik-cache/system@app@htcmailwidgets.apk@classes.dex
rm /data/dalvik-cache/system@app@Mail.apk@classes.dex

#Removes HTC Sprint Service
echo "--Removes HTC Sprint Service"
rm /system/app/HtcSprintService.apk
rm /system/app/Sprint_InstallerNC_v2_1_0.apk
rm /data/dalvik-cache/system@app@HtcSprintService.apk@classes.dex
rm /data/dalvik-cache/system@app@Sprint_InstallerNC_v2_1_0.apk@classes.dex

#Removes Polaris Office
echo "--Removes Polaris Office"
rm /system/app/PolarisOffice.apk
rm /data/dalvik-cache/system@app@PolarisOffice.apk@classes.dex

sleep 2
echo "Removal of Apps complete."

sleep 2
echo "Removing Unwanted HTC Skins"

#Removes HTC PureBlack Skin
echo "--Removing HTC PureBlack Skin"
rm /data/app/PureBlack.apk

sleep 2
echo "Removal of HTC Skins complete."

And after you do remove these. You will need to go to Settings>apps>running services>all>click on HTC Sense (the one with the htc clock icon) and clear data. This way you wont have 'false' widgets showing up in your widget menu. It pretty much refreshes HTC sense with the current applications.

If you want to do it, you can PM me and I'll help you get it started.

It may not take out much space, but every little bit helps.