11/12/72
5:00P.M.

Los Angeles, California.
3440 Wilshire Boulevard,
Mra. Norton Simon.

Henry A. Kleisinger

With warm regards,

My best wishes to Norton.

Paign.
You and Dr. Mexler great success in your cam-
Hereditary Disease Foundation, however, and wish
I much admire your efforts on behalf of the
I much admire your efforts on behalf of the

or I would be overwhelmed.
To a policy of not making donations to any organization,
saaming this position. I have had to adhere strictly
to a request for a contribution to a worthy cause,
tougheat negotiating team head on than turn down a
Although I would rather face the world's

Dear Jennifer:

JENNIFER JONES SIMON
3440 WILSHIRE BOULEVARD
LOS ANGELES, CALIFORNIA 90010

November 3, 1975

The Honorable Henry Kissinger
Office of the Secretary of State
Washington, D. C.

Dear Henry:

Months ago I contacted many friends, doctors and business
leaders to discuss Huntington's Disease and its implications
for the entire field of genetic research. I mentioned a
promising new program that we were supporting at Cal Tech,
and I told of my deep feelings for the dedicated work of Dr.
Milton Wexler and the Hereditary Disease Foundation. At the
time, I stated explicitly that my letter was not a solicitation
for funds.....this one is.

To date all research on Huntington's has been funded by private
contributions. Now, at least, there is some recognition in
Washington of the implications of this research. The government
is beginning to recognize that a solution to this devastating
disease may provide clues to many hereditary diseases, as well
as some keys to understanding much more about aging, cancer, and
mental illness. A Federal Commission to look into Huntington's
has been authorized and is now being formed. We have been told
that federal funds may be available in one year.

But while the government commission is being organized, research
cannot wait. Funds are needed immediately to support vital
projects which are underway. Your contribution can help us
demonstrate to the Commission that people are concerned about
this problem, and it will help in our efforts to accelerate
the Commission's planning and funding.

The enclosed material was prepared for me by Dr. Wexler to
answer some of the important questions about Huntington's. I
think it is enlightening.

Rarely have I asked for funds...rarely will I do it again. But
this time I am asking. Please send what you can. It is needed.

FOUNDATION FOR RESEARCH IN HEREDITARY DISEASE

465 NORTH ROXBURY DRIVE, BEVERLY HILLS, CALIFORNIA 90210 • (213) 274-1155

H. D. FOUNDATION

H. D. FOUNDATION

H. D. FOUNDATION

October 29, 1975

To: Jennifer

From: Milton Wexler

We are all most grateful for your
offer to help. Below are notes in
response to the questions you
raised. I hope, among other things,
they communicate the urgency that
truly exists.

BOARD OF TRUSTEES

MR. TED ASHLEY
MRS. ELAINE ATTIAS
MARYLINE BARNARD, PH.D., TREAS.
MRS. MICHAEL J. FASMAN, SECY.
MR. MICHAEL J. FASMAN
MRS. HAROLD E. KOERBER
MR. FRANK O. GEHRY
MRS. RICHARD GOLD
MRS. ESTELLE GRAHAM
MR. & MRS. MORTON A. HELLER
MR. ROBERT T. HIGASHI
MR. EDWIN JANSJR.
MR. & MRS. NICOLAI JOFFE
MR. RAYMOND E. LEE
MARVIN MEYER, ESQ.
MRS. RITA MORRISON
MR. & MRS. RICHARD O'NEILL
MRS. ARMAND OPPENHEIM
MR. & MRS. SENIEL OSTROW
MISS CATHY PATTIZ
MRS. JOYCE REED ROSENBERG
MRS. SANDY ROTH RUBEN, V. PRES.
MILTON A. RUDIN, ESQ.
DR. & MRS. BERNARD SALICK
MR. & MRS. SAMUEL SCHULMAN
MR. & MRS. MORTON STERLING
MR. & MRS. FREDERICK R. WEISMAN
MILTON WEXLER, PH.D., PRES.

SCIENTIFIC ADVISORY BOARD

ANDRE BARBEAU, M.D.
DAVID S. BARKLEY, PH.D.
JOHN H. BIEL, PH.D.
MARY A. B. BRAZIER, PH.D.
NATHANIEL A. BUCHWALD, PH.D.
THOMAS N. CHASE, M.D.
DAVID COMINGS, M.D.
EDWARD H. DAVIS, M.D.
WILLIAM J. DREYER, PH.D.
LEON FREEMAN, PH.D.
OLEH HORNYKIEWICZ, M.D.
RONALD J. KONOPKA, PH.D.
CHARLES H. MARKHAM, M.D.
STEVEN MATTHYSSE, PH.D.
JOHN H. MENKES, M.D.
NTINOS MYRIANTHOPOULOS, PH.D.
RONALD OKUN, M.D., CHMN.
PROFESSOR LINUS PAULING
EUGENE ROBERTS, PH.D.
BERNARD SALICK, M.D.
W. W. TOURTELLOTTE, M.D.
NANCY WEXLER, PH.D.
MILTON WEXLER, PH.D.

***

1. WHY HEREDITARY DISEASE?

Because it is a major area for developing programs of effective preventive medicine. Because even the discovery of good diagnostic techniques can result in enormous savings in human suffering and economic costs. Because at least 2,000 known genetic illnesses are involved. Because 15 million Americans suffer birth defects, most of which have a genetic factor. There is a great and fascinating medical research task here of the greatest consequence to people of this nation and the world.

2. WHAT IS HUNTINGTON'S DISEASE?

It is a hereditary illness due to a gene defect. Once thought to be a "rare hereditary disease," we now know of over 100,000 heirs to this nightmare in the United States alone. It is a neurological disorder leading to devastating destruction of brain cells. 50% of the children of a parent with H. D. will inherit this dread ailment. However, generally there are no symptoms showing before the victim is 35 or 40 years of age.

Then brain cells die. Fast. This is manifested in many ways. Difficulties with speech. Loss of muscular control. Body twitching. Changes in personality. Often insanity. And always, after ten to fifteen years of hell, comes death.

NB: Before symptoms appear, most people have married and had a family. The disease has already been passed on to another generation! As devastated as these victims are, they come repeatedly for research studies - not for themselves but in the hope that they can do something to save their children from the same fate.

[LC]

page 2

### 3. WHY HUNTINGTON'S DISEASE?

It is a model hereditary illness. Its study could illuminate a great many mechanisms in all genetic disease. It could also clarify the nature of heredity; the functions of the brain; mental illnesses; the mechanisms of aging; a host of significant medical issues. Beyond that, it is a diabolical, tragic, and immensely costly disease. Its economic burden on families, and more markedly on government and the taxpayer, runs to the billions.

### 4. WHAT IS THE FOUNDATION FOR RESEARCH IN HEREDITARY DISEASE?

It is a public foundation dedicated to medical research in the areas of hereditary disease. Its special emphasis is the model represented by Huntington's Disease. All contributions to the Foundation, whether by individuals or corporations, are tax deductible at both State and Federal levels. 89.9% of all contributions made to this charity have been expended solely on medical research.

### 5. WHAT IS THIS FOUNDATION DOING IN THE AREA OF RESEARCH?

With relatively little money and as small as we are, the research the H. D. Foundation sponsors is being conducted in the finest scientific laboratories in the country: Cedars-Sinai, Harvard, Stanford, UCLA, City of Hope, Albert Einstein Medical School, Boston University, Yale, University of Southern California, Cal Tech, and a host of other institutions.

Our Scientific Advisory Board includes some of the major scientific and medical contributors anywhere. To mention a few (see letterhead): Eugene Roberts, with major discoveries in the area of neurotransmitters; Oleh Horneykiewicz and Andre Barbeau of Canada, with significant contributions to the treatment of Parkinson's Disease; Professor Linus Pauling, a double Nobel Prize winner and recent recipient of the President's National Science Award; etc.

The Foundation has been at work for a little more than five years. In that time, we've initiated genetic linkage studies at the University of Colorado and at UCLA. We've established an H. D. Tissue Bank at the V. A. Hospital here in Brentwood. We've begun to get positive results on tests for early diagnosis. We've seen an essential brain substance called, GABA, in mighty short supply in the brain of the H. D. patient. Perhaps, someday we can replace it and the symptoms will be alleviated. (This is the same principle that worked in the cases of Diabetes with insulin and in Parkinson's Disease with L-Dopa.)

There is a long and exciting list of scientific-medical research which the Foundation has sponsored. There are distinguished accomplishments. Perhaps, though, one of the most innovative and promising developments has been the Foundation's sponsorship of a rewarding series of Workshops on Huntington's Disease.

[LC]

page 3

5. RESEARCH continued:

These Workshops have not only developed extraordinarily rich hypotheses and experimental approaches to the investigation of hereditary defects, but they have also proved the wealth of communication possible when a mix of medical researchers, basic scientists and technological experts are brought together for free exchange of ideas.

Faced with profoundly complex medical challenges, we have discovered that individual genius in this age of vast specialization is often inadequate to the task. By mixing specialists from different areas of knowledge, we have not only vastly enriched the process of hypothesis building, but we have also captured the imaginations and loyalties of a large number of scientists. We have involved them deeply in the conduct of research to answer the very questions they raise.

It is a technique with rich rewards in science. And in medicine. I have a hunch it may even have applications in the field of industry.

6. WHAT IS THE PRESENT URGENCY?

This is an exciting moment. Congress has just established a COMMISSION FOR THE CONTROL OF HUNTINGTON'S DISEASE. That's the illness, the H.D. Foundation chose long ago as a model hereditary disorder that could prove a window on the mechanisms of all genetic illness. How terribly important it is, therefore, that the Foundation now accelerate its Huntington's Disease research; define the many areas in which basic knowledge is needed; and be prepared in an energetic way to collaborate with this important Commission. We must help to make the execution of its assigned task more effective.

7. ECONOMICS OF HEALTH CARE AND HEALTH RESEARCH

With health care funding running over 100 billion dollars in 1974 alone and research in medicine getting only 2% of that amount, it seems time we got behind bio-medical research to insure solutions for some of our most critical and costly problems. The potential savings in suffering and in health care costs can run very high. It is clear we must invest some in order to save a lot. With many billions of taxpayers' dollars involved, even a few discoveries can prove a great investment.

***

Federal Energy Office.
Administrator,
William E. Simon,
The Honorable

Henry A. Kissing

Warm regards,

thank them all on my behalf.
Energy Office played important roles. Please
I know that many others at the Federal

effect on the outcome.
no question that your presence had a major
your Plenary address magnificent. There is
biton during our preparations was invaluable,
Washington Energy Conference. Your contri-
deeply grateful to you for your part in the
I want you personally to know that I am

Dear Bill:

February 19, 1974

THE SECRETARY OF THE TREASURY

WASHINGTON, D. C. 20220

May 13, 1974

Dear Henry:

You and Nancy missed a good party while you were out of the country -- namely, the reception for George and Obie held at the State Department on May 7th.

I just wanted to let you know that you were missed, and also to thank you for the fine assistance we received from your staff. I especially want to commend Assistant Secretary John Thomas and Mr. Harvey Buffalo for their courteous and able assistance.

With best wishes,

Honorable Henry A. Kissinger
Secretary of State
Department of State
2201 C Street, N. W.
Washington, D. C. 20520

THE SECRETARY OF THE TREASURY

WASHINGTON, D. C. 20220

AUG 28 1974

Dear Henry:

I would be very happy to speak to your
Conference for Senior Business Executives on
September 5. Fortunately, I have been able
to reshuffle my schedule since I was planning
to leave early that afternoon for Dallas for
a speaking engagement. As you have suggested,
I plan to speak for about 15 minutes with the
remainder of the time reserved for questions
and answers.

I appreciate your invitation and look
forward to attending the meeting, although
at this time I do not believe I will be able
to attend the reception.

Looking forward to seeing you.

With best regards,

The Honorable
Henry A. Kissinger
The Secretary of State
Department of State
Washington, D. C. 20520

THE SECRETARY OF THE TREASURY

WASHINGTON 20220

February 11, 1975

Dear Lew:

Two items appearing on your "Washington Outlook" page of February 17 are so astonishingly inaccurate that they constitute one of the saddest examples of poor reporting I have seen.

First, you cite "associates" of our new Labor Secretary nominee, John Dunlop, as your source for cracks at our relationship, then blandly predict that "friction between the two seems certain." Had your reporter checked this out with John Dunlop, he would have found that we've long been friends and co-workers. As it stands, the comment is a disservice to a man of dedication and character -- one the nation should be proud to welcome to his vital new position in Washington.

Second, in the very next item, you make the incredible assertion that I am out "to sabotage Kissinger's diplomacy." Can Business Week really believe this? In a time of such international tension, when the stakes for peace are so high? Where is the journalist's commitment to truth and accuracy in making such a statement?

The entire paragraph containing this perversion of fact is so far off base from what your reporter was told by the Treasury's Deputy Assistant Secretary for Research, Thomas D. Willett, that it is depressing to read. For example, Willett did _not_ say, as you stated, that "his study is 'unbalanced' and was _done in haste'_-- only that the _news release_ on it was.

Surely Business Week can do better than this. We are accustomed to looking to your magazine for accuracy of information and clarity of interpretation. I would like to think we could continue to do so.

Mr. Lewis H. Young
Editor-in-chief
Business Week
1221 Avenue of the Americas
New York, New York 10020

The Honorable Henry Kissinger

Washington outlook

February 17, 1975 / Edited by Bruce Agnew

Dunlop heads for the Labor Dept.

Former wage and price controller John T. Dunlop, whose nomination as Labor Secretary was imminent this week, will bring a blunt voice to top levels of Administration policymaking. He will represent a new force in the shifting balance of power among President Ford's top economic advisers.

Dunlop, director of the Cost of Living Council during the Phase III and IV controls era, will not be content to serve merely as Ford's liaison with organized labor.

Dunlop will have an important impact on Ford's policy decisions. He is a back-room operator whose advice will be shaped by long experience brokering labor-management relations, a sophisticated understanding of Congress, and a growing skepticism of conventional economics. Some of his views already are well-known:

DOS Enterprises

John Dunlop

* He opposes wage-price controls, but is not afraid of them. If controls are reimposed, he would favor the Korean War model, an industry-by-industry approach to take account of differing problems. He believes government intervention in the economy is a fact of life: The course he has been teaching at the Harvard Business School was titled "Private Decision-Making Under Wage and Price Controls."

* He believes the Council of Economic Advisers cannot handle microeconomic problems—the botlenecks and structural difficulties of individual industries. He favors a new government agency to tackle them.

* He does not have high regard for at least one top member of Ford's team—Treasury Secretary William E. Simon. He turned down the job of chairman of the CEA in 1974, associates say, at least partly because he did not want to work under Simon. Friction between the two seems certain.

Kissinger's oil crisis

Domestic politics—including in-fighting within the Administration—could undermine Secretary of State Henry Kissinger's grand design for oil diplomacy.

Kissinger is stepping up efforts to forge a common front of oil-consuming nations before they confront the OPEC producers at a preliminary conference next month. The most dramatic signal was his proposal this week for an international floor

price for oil. But his plans are running into trouble at home. Congressional Democrats are backing away from the Administration's import-cutting goals because they fear the impact on the economy. That could derail Kissinger's strategy. If the U. S. does not carry out a tough oil conservation program, other countries will ease up, too.

Another threat is the flurry of studies suggesting that the petroduollar crisis has been overblown. One especially—a Treasury study by Thomas D. Willett, deputy assistant secretary for research—concluded that OPEC's surplus reserves by 1980 may total only half of the earlier estimates. Willett now warns that his study is "unbalanced" and was done in haste. But high State Dept. officials view it as another effort by Treasury Secretary Simon to prove that no heroic international measures are needed to deal with the oil crisis—and in the process, to sabotage Kissinger's diplomacy.

Tight rules for chemical hazards

The new Congress may significantly broaden the toxic substances bill that died in last year's adjournment crunch. Last year's bill would have required safety testing only of final products intended for sale. But labor is pushing hard for testing of any new chemical to be used in the production process, and the Administration may go along. The Occupational Safety & Health Administration has set a task force to work sounding out industry and labor on the issue.

Capital wrapup

Trade flap: Deputy Attorney General Laurence Silberman, the almost certain White House nominee as special representative for trade negotiations, is winning the job over the opposition of Secretary of State Kissinger. Kissinger argued that Silberman has neither the background nor the prestige. But Silberman was backed by White House economic policy aide L. William Seidman, whose power is growing. The nomination may have a rough time-in the Senate.

In-house jawbone: The Office of Management & Budget has finally ordered government agencies to start drawing up the "inflation impact statements" that President Ford wants issued with major decisions. Just like corporations, federal agencies now will have to be ready to justify their actions to the Council on Wage & Price Stability if COWPS thinks they are out of line.

THE SECRETARY OF THE TREASURY

WASHINGTON 20220

July 7, 1976

Dear Henry:

I was shocked when you told me during our meeting in New York that Treasury had threatened to invoke the Freedom of Information Act if a particular cable was not declassified. As a consequence when I returned to the office yesterday I immediately checked to see what had actually transpired. I have the following account.

-- A middle level officer of my staff raised with Charles Naas, your country director for Iran, the question of whether the cable from Helms could be declassified for my use. Naas then said that we might have to invoke the Freedom of Information Act if we wanted the classification removed. My staff officer expressed the view that this was not a Freedom of Information Act matter, emphasizing that we were merely seeking State's view as to whether the cable could be declassified and if that was not possible whether it could be "sanitized."

-- Naas then passed his version of this encounter to Eagleburger which suggested that we would invoke the Freedom of Information Act if our request were denied. Nothing could be further from the truth. We were merely seeking a State Department decision on a message originated by an American Embassy abroad. We have never had any thought that Treasury would involve the Freedom of Information Act.

It is inexcusable in my mind that a request of this kind could be so incredibly garbled and then passed to the highest level in a government department. I also find it shattering that such nit wits are in positions of responsibility within our government.

The Honorable
Henry A. Kissinger
Secretary of State
U. S. Department of State
Washington, D. C. 20520

THE SECRETARY OF STATE
WASHINGTON

November 11, 1976

Dear Bill:

I am delighted to have a copy of *The Ethical Basis of Economic Freedom*, and am deeply touched and honored by your inscription. There could be no better model for courageous leadership and personal integrity than you have been, and it is fitting that your chapter should be the summing up.

Now that the tumult and the shouting have nearly died, and both of us will soon find ourselves in vastly altered spheres of influence, I am hoping beyond all else for a continuation of our close personal friendship, which I have always valued so highly.

The Honorable
William E. Simon,
Secretary of the Treasury.

Speaking of his troubles, you may remember that when Senator Kefauver was trying to become president over Bill's dead boxdy we had a few troubles ourselves. I therfore can sympathize with him in his present ordeal. It must be sheer unadulterated hell.

In any case, you are with us. And if Mr. Rockefeller runs for the presidency and you are with him, I'm voting for him too.

It may sound ridiculous but I hope God keeps you safe because God knows we need you.

In addition you are an extremely nice man and I want to meet your extremely nice wife and you know you have a non pushy friend in Acapulco who will be delighted to do anything she can for you at anytime.

Very sincerely

P.S. Braniff did not employ me as a secretary so please don't judge them for my typing.

SLOANE SIMPSON

COSTERA MIGUEL
ALEMAN No. 1070

4-08-83

ACAPULCO.

To the day compared, the celebration received from all: Carlos Magana Campos; Leander P. Vourvouliasis, Juan D. Sanchez; George N. Furgelsang; and Eduardo the energy crisis. Mikey de la Torreta

[LC]

# Mexican Investment Promoted in US

By R. ALBERT DENBOW

The Mexican National Tourist Council is sponsoring an investment promotion in four U.S. cities. Theme of the conferences is "The Mexican Policy for Foreign Investment in Tourism."

Starting point for the tourism mission will be the Century Plaza Hotel in Los Angeles on Thursday. The group will then continue to the Hotel Pierre in New York City. June 10; the Hotel Drake in Chicago, June 12; and the Fairmont Hotel in Dallas, June 14.

The object of the tour is to orient and encourage potential U.S. investors in Mexico tourism.

Representing the Mexican National Tourist Council is general coordinator Miguel Guajardo. He will talk on the current state of Mexican tourism. Other speakers will include Antonio Enriquez Savignac, head of the National Fund for Tourism Promotion (FONATUR) who will discuss investment and development opportunities. Antonio Correa, Jr., of Basham, Ringe & Correa, who will deal with trust and foreign investment laws; and Hermann

von Bertrab, Banco de Comercio, who will talk on establishment of real estate trusts. Other speakers will deal with various aspects of U.S. and Mexican taxes.

Providing a backup to the

## 'Business Week' Spotlights Mexico

By FELIX-ARCINIEGA

A 22-page special section called "Mexico Magnifico" appears in the current May 25 issue of Business Week magazine. It deals extensively with Mexico's economic development, tourist attractions, convention facilities, new and projected sea-side resorts and Baja California development programs.

"The section was produced by RKL Associates of Mexico City.

Most of the text by author Richard Dunlop, past president of the Society of American Travel Writers. He explains in detail Mexico's new regulations to permit foreigners the legal right to use and derive benefits from land in hitherto restricted border areas.

A foreword by Miguel Aleman, president of Mexico's National Tourism Council, extends an invitation to foreign investors to join in the development of the nation's tourism facilities and describes how new highways and airports have opened vast, previously inaccessible areas of the country to overall development and especially by the new Baja California trans-peninsular highway.

In his portrait of Mexico, Dunlop refers to Mexico "as the land next door to English-speaking North America whose warm and sunny life style is a world away." In doing so, Dunlop underlines the impact and cultural differences that make it attractive for conventions and post-convention tours.

He also speaks highly of the Mexico City Convention Office and its experienced staff who can handle needed paper work and physical arrangements for conventions of any size and also its valuable assistance in obtaining temporary import permits for exhibits and convention material.

Of the recently opened Acapulco Cultural Convention and Exhibition Center, Dunlop

overall theme, local lawyers from each of the selected cities will provide information on SEC and HUD registration.

Other participants in the joint effort to encourage

in three simultaneous events.

With the completion of the 80-million-dollar highway from the U.S. border to the southernmost tip of the Baja California, one of the world's most isolated regions has been opened to what the Mexican government promises will be balanced development, and the Comision Coordinadora para el Desarrollo Integral de la Peninsula de Baja California or, more conveniently, CODIBAC, has been charged with one of the most significant of all 20th century Mexican projects, another article in Business Week says.

Describing the area as "very close to the Garden of Eden," CODIBAC reports that it is not only concerned with encouraging Mexican and foreign investment but is doing all else necessary to bring economic and social progress to the peninsula.

"Supplemental roads to the great trans-peninsular highway are under construction. International airports have been opened and airfields for private planes have been built, usually with rustic hotel accommodations for the fly-it-yourself visitor.

"Ferryboat service from Baja to the mainland ports of Guaymas, Topolobampo, Mazatlan and Puerto Vallarta has been opened with sea-going ferries.

"This allows U.S. motorists to drive down through

foreign investment in Mexican tourism are the Banco Nacional de Mexico, Braniff Airlines, Promociones Turisticas Industriales and Tres Vidas en la Playa Hotel, Acapulco.

some of the most exciting scenery in the world, cross to the mainland and return to the States by another route," CODIBAC writes.

"Although most of the tourist areas planned for Baja California are to be developed by private enterprise, both Mexican and foreign, under appropriate trust agreements, the ports of San Felipe and Cabo San Lucas are being built by the public sector. San Felipe is intended to become one of the great yachting ports on the west coast of North America," CODIBAC explains.

In the story: "Manzanillo... an Eye on the Sunset." Business Week cites Manzanillo development as beginning in 1970 with the Roca del Mar 40 unit project constructed under provisions of President Echeverria's decree which permits foreigners to enjoy the rights of ownership to properties on the Mexican coastline.

"With the opening of Antenor Patiño's Las Hadas Hotel and the El Tesoro condominium complex across the bay from Manzanillo, its sunny beaches are coming into their own and the region will soon become known as the Mexican Riviera. Additional plans for both condominiums and hotels to the north of Manzanillo promise to make the area one of Mexico's foremost resorts, the article explains.

## GENERAL MANAGER

PRESTIGIOUS, PROFITABLE U.S. PHARMACEUTICAL FIRM'S SEEKS A MANAGER EXPERIENCED IN MARKETING AND DEVELOPING OF ETHICAL PHARMACEUTICALS. TWO TO THREE YEARS GENERAL MANAGEMENT EXPERIENCE DESIRABLE. PREFER MEXICAN NATIONAL FLUENT IN ENGLISH AND SPANISH. ATTRACTIVE COMPENSATION PACKAGE. JUNE INTERVIEWS. SUBMIT RESUME AND COMPENSATION HISTORY, IN ENGLISH, TO OUR CONSULTANT: RAY C. PRUITT, PhD., EVANS ASSOCIATES, INC., 44 MONTGOMERY STREET,