DECEMBER 27, 1890.

SCIENTIFIC AMERICAN SUPPLEMENT, No. 782.

12489

space for the air in the lung, which might become fatal in these advanced cases. These transitory inflamations probably bring on the healing process.

Dr. E. Kromeyer, of Halle, examined portions of lupus tissue excised from a patient affected with that

cutaneously in any part of the body, but preferably between the scapula. No reaction appears locally, but at the end of four hours severe constitutional effects are manifest in the appearance of rigors with malaise, followed by a temperature which may reach

usually of short duration. Subsequent injections are not attended with systematic disturbances. Over the surface and in the neighborhood of tuberculous swellings, scabs appear which, on being separated, leave healthy granulating surfaces. Cases in that stage are said to be cured, inasmuch as they show no constitutional reaction.

DR. KOCH'S REMEDY FOR TUBERCULOSIS—DR. BERGMANN SUPERINTENDING THE INJECTION OF THE LYMPH.

disease, and concludes that the injection brings on an inflammation of the structures surrounding the tubercle, which results in suppuration of the same.

Professor Koch's *Lymph*.—The material used by Professor Koch in his inoculations for tuberculosis is a viscid fluid, the color of a dilute solution of iodine, is of a slightly siaky consistence, and is supplied in white glass corked bottles containing each about forty grammes.

It is prepared for use by adding one hundred grammes of sterilized water, the maximum dose of injection being one gauze. The injection is made sub-

106° F., with a corresponding increase in the pulse- beat from 130 to 160. Vomiting frequently occurs at the acme of the fever. In some cases the reaction is attended with alarming symptoms, very great prostration, requiring the use of stimulants, and severe dyspnoea.

When the tuberculous deposit is superficial there is in and around it great tunefaction. The amount of constitutional disturbance is said to be governed by the extent of the tubercular deposit. This is noted particularly in cases of lupus and in tuberculous glands of the neck. The constitutional symptoms are

AN INTERVIEW WITH PROFESSOR KOCH.
BY DR. CHARLES HACKS, IN "L'ILLUSTRATION."

"My hour of consultation is between 12 and 1 o'clock," signed "Koch." This is written on a little square piece of paper fastened by four pins in a gray frame against the wall at the foot of the grand staircase in the entrance of the Imperial Hygienic Institute, in Berlin, and it was this that four European reporters were studying on the 5th of November, at 9 o'clock in the morning. Alas! what an illusion! Many others have been stopped by that little card, and gone no further. It is not easy, in fact, to reach this celebrated savant. From the porter to the secretaries, every one is extremely reserved in that house. It is almost impossible not to have one's card intercepted before it reaches its destination. We had the good fortune, nevertheless, to overcome all obstacles, and by exceptional favor obtained admission. We are going to try to lift a corner of the veil under which the German sphinx lies hidden, and to show to all the world the great question of the cure of consumption and by what intellectual and experimental processes the present condition of the science has been reached.

The intimate friend and adviser of Dr. Koch received us in his private study on the third floor of the institute. On the door is a little card on which are the words "Dr. Koch." The room is very small, and is partly filled by an enormous stove of faience, which reaches to the ceiling, and opposite to it is a large table covered with green and provided with two drawers. At the end of the room near the window is a little oak bureau, on which we perceived two proofs of photographs of which so much has been said, and which ought to be annexed to the report which is waited for with so much impatience. They represent two forearms with a hand showing the scars of tubercular lesions that have been cured, and photographs of which have been taken from day to day.

Prof. Koch immediately arose and stretched out his hand to me.

"I am very pleased to meet you," said he. "I remember very well our former intercourse at Marseilles at the time of the cholera in 1885. I remember also that you were the first one to translate my works and discoveries, but," and he held my card in his hand, "I guess the cause of your visit, and regret to say that I will not be able to tell you all I would like."

"Nevertheless," I replied, "the French public wish to know you, and to know and to see something of you and of what relates to your researches. That you will certainly grant me. In the first place, let me ask you for your photograph signed."

I then asked him for a tube containing some bacilli. Prof. Koch passed immediately into a neighboring room and came back holding in his hand a tube containing the *culture*, which he gave to me.

"Will you authorize me to say that these came directly from your laboratory and were given to me by you?"

"You know very well that I am a simple man, and how much I fear the notoriety which has arisen. Nevertheless, you desire it, and I give you the authority."

"Since you are in the vein, what would you think of letting me have a tube of the *culture* of comma bacilli of cholera? You are probably the only person in the

DR. KOCH AT WORK IN HIS LABORATORY.